CN105273095A - Preparation method for sugammadex and intermediates thereof - Google Patents
Preparation method for sugammadex and intermediates thereof Download PDFInfo
- Publication number
- CN105273095A CN105273095A CN201510241131.3A CN201510241131A CN105273095A CN 105273095 A CN105273095 A CN 105273095A CN 201510241131 A CN201510241131 A CN 201510241131A CN 105273095 A CN105273095 A CN 105273095A
- Authority
- CN
- China
- Prior art keywords
- preparation
- compound
- reaction
- formula
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)C(*1)C(C)CO[C@@]1(CO)OC(CO*(C1*)O[C@@](C2)O*C(*CC(CC=O)C(*(C(C)O)O)OC3OC(C*)C=C(*C(CC4O)OC(CO)*4C([Mn]C)=C)[C@@](C)C3O)C(C)CC2(C[N+]([O-])=O)[Mn])C1O Chemical compound CC(*)C(*1)C(C)CO[C@@]1(CO)OC(CO*(C1*)O[C@@](C2)O*C(*CC(CC=O)C(*(C(C)O)O)OC3OC(C*)C=C(*C(CC4O)OC(CO)*4C([Mn]C)=C)[C@@](C)C3O)C(C)CC2(C[N+]([O-])=O)[Mn])C1O 0.000 description 2
Abstract
The invention provides a preparation method for sugammadex and intermediates thereof. The method comprises a step that a compound in the formula (I) and a chloride agent are subjected to a chlorination reaction, wherein the chloride agent is selected from thionyl chloride and oxalyl chloride. The formula (I) is shown in the specification. The method is advantaged by simple technology process, high yield, high purity and no pollution, and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of preparation method of easypro more glucose sodium and intermediate thereof.
Background technology
The more glucose sodium (sugammadex) that relaxes is the neuromuscular block reversal agents produced for the neuromuscular blocking agents such as Zemuron or vecuronium bromide (NMBA, also referred to as muscle relaxant) induction of Merck company exploitation.
The reversal agents of neuromuscular blocking agents often gives the patient at the end of the intensive cure of surgical operation or for some time, helps it and recovers muscle function.The reversal agents of conventional neuromuscular blocking agents is acetylcholinesterase depressant (AChE), as edrophonium chloride, prostigmin(e), pyridostigmine bromide, is not suitable for the reversion of depolarizing NMBA as succinylcholine.AKZONOBELN.V. once reported that chelating agent (title complex that neuromuscular blocking agents and reversal agents are formed) was as reversal agents, all effective with reversion depolarizing NMBA to nondepolarizing neuromuscular narcotic.The conventional methods for the treatment of for deep anaesthesia is the acetylcholinesterase depressant by high dosage; this type of reversal agents can bring out one " high cholinergic crisis "; and the untoward reaction of the broad range relevant with the stimulation increasing muscarinic receptor and nicotine receptor can be caused, and the chelating agent not improving the level of vagusstoff would not have this kind of side reaction to produce.So compare the reversal agents of conventional acetylcholinesterase depressant type, chelating agent produces less side effect, can safety for reversion " deep anaesthesia ".
The more glucose sodium that relaxes is a kind of modified γ-cyclodextrin, is one group of oligosaccharides, has the right cylinder capsule of lipophilic core and hydrophilic outer end.It can enter in extracellular fluid and blood plasma, wraps up the neuromuscular blocking agentss such as free Zemuron, vecuronium bromide fast, form more stable title complex by the lipotropy of easypro more glucose sodium inner ring; Highly hydrophilic this title complex that makes of easypro more glucose sodium outer shroud is discharged from urine with original shape, thus the concentration of the neuromuscular blocking agents such as Zemuron, vecuronium bromide in extracellular fluid and blood plasma is reduced, the neuromuscular blocking agents such as Zemuron, vecuronium bromide that the concentration gradient formed thus contributes to remaining turns back to extracellular fluid and blood plasma from neuromuscular junction, can the neuromuscular blockade effect of quick, effective, safe antagonism different depths.
About the technology of the more synthetic technology mainly patent (WO-0140316) of AkzoNobel company of glucose sodium of relaxing, its synthetic route is as follows:
This route take γ-cyclodextrin as raw material, in DMF solvent, first with triphenylphosphine, iodine, DMF, Vilsmeier-Hack occurs and reacts; Again with mercaptan generation substitution reaction, last and NaH salify, generates the more glucose sodium that relaxes.But produce triphenylphosphine oxide in this route reaction, aftertreatment purifying is very difficult, need under nitrogen atmosphere, use DMF repetitive scrubbing, productive rate is very low, is not suitable for industrialized scale operation, needs to be optimized improvement to this technique.
In order to search out a high purity, the method for high yield, environmental protection, by product easily remove, the synthesis of reaction conditions gentleness is relaxed more glucose sodium, through further investigation, invented and be applicable to industrialization and relax the production method of more glucose sodium and intermediate thereof.
Summary of the invention
The present invention aim to provide a kind of simple to operate, mild condition, product yield are high, purity is high, water pollution-free, environmental protection the production method being applicable to industrialized relax more glucose sodium and intermediate thereof.
The invention provides the preparation method of the easypro more glucose sodium intermediate of a kind of formula (II), described method comprises formula (I) compound and chlorination reagent carries out chlorination:
Wherein, chlorination reagent is selected from thionyl chloride or oxalyl chloride, preferred oxalyl chloride;
Preferred version of the present invention, the preparation method of the compound shown in a kind of formula (II), described method comprises:
(A) under rare gas element atmosphere, chlorination reagent is added drop-wise in DMF at-10 ~ 20 DEG C of temperature, preferably under nitrogen atmosphere, oxalyl chloride is added drop-wise at 0 ~ 10 DEG C in dry DMF; Preferably drip at 0 ~ 5 DEG C further;
(B) dropped in step (A) reaction system by the mixing solutions of formula (I) compound and DMF, being warming up to temperature of reaction is react at 50 ~ 100 DEG C; Preferably 50 ~ 80 DEG C of stirring reactions; More preferably 60 ~ 70 DEG C of stirring reactions, temperature of reaction preferably 65 ~ 70 DEG C further;
(C) step (B) reaction system is cooled, join in frozen water, with alkali regulation system solution to alkalescence, separate out solid, filter and obtain formula (II) compound; Preferable ph to 8 ~ 10, further preferable ph 8 ~ 9.
Preferred version of the present invention, the preparation method of the compound shown in a kind of formula (II), described chlorination reagent is selected from oxalyl chloride.
Preferred version of the present invention, the preparation method of the compound shown in a kind of formula (II), step (B) temperature of reaction is preferably 60 ~ 70 DEG C; Further preferably, temperature of reaction 65 ~ 70 DEG C.
Preferred version of the present invention, the preparation method of the compound shown in a kind of formula (II), in step (C), alkali is selected from mineral alkali and organic bases, preferred mineral alkali, further potassium bicarbonate, salt of wormwood, sodium bicarbonate, sodium carbonate, sodium hydroxide or potassium hydroxide.
Preferred version of the present invention, the preparation method of the compound shown in a kind of formula (II), in step (C) system, system solution is adjusted to the pH value of alkalescence is 8 ~ 10, preferably 8 ~ 9.
Preferred version of the present invention, the equivalents ratio that chlorination reagent and raw material γ-cyclodextrin react is 1:10 ~ 1:40; Preferred 1:16 ~ 1:34; Preferred 1:16 ~ 1:26 further.
A preparation method for easypro more glucose sodium, comprising:
(1) formula (I) compound and chlorination reagent are obtained by reacting formula (II) compound;
Wherein, chlorination reagent is selected from thionyl chloride or oxalyl chloride;
(2) formula (II) compound and 3-thiohydracrylic acid react and prepare the more glucose sodium that relaxes:
Preferred version of the present invention, formula (II) compound and 3-thiohydracrylic acid react and prepare in easypro more glucose sodium, and the equivalents ratio that formula (II) compound and 3-thiohydracrylic acid react is more than 1:10; Preferred 1:10 ~ 30; Preferred 1:11 ~ 16 further.
Preferred version of the present invention, the equivalents ratio that the raw material γ-cyclodextrin of chlorination reagent and formula I reacts is 1:10 ~ 1:40; Preferred 1:16 ~ 1:34; Preferred 1:16 ~ 1:26 further.
Preferred version of the present invention, the preparation method of the compound shown in its Chinese style (II) comprises:
(A) under rare gas element atmosphere, chlorination reagent is added drop-wise in DMF at-10 ~ 20 DEG C of temperature, preferably under nitrogen atmosphere, oxalyl chloride is added drop-wise at 0 ~ 10 DEG C in dry DMF;
(B) mixing solutions of formula (I) compound and DMF is dropped in step (A) reaction system, be warming up to 50 ~ 100 DEG C of reactions; Preferably 50 ~ 80 DEG C of stirring reactions; More preferably 60 ~ 70 DEG C of stirring reactions, preferably 65 ~ 70 DEG C further;
(C) step (B) reaction system is cooled, join in frozen water, with alkali regulation system solution to alkalescence, separate out solid, filter and obtain formula (II) compound; Preferred alkaline ph values to 8 ~ 10, further preferable ph 8 ~ 9.
Preferred version of the present invention, wherein, described chlorination reagent is selected from oxalyl chloride.
Preferred version of the present invention, wherein, in step (B), temperature of reaction is preferably 60 ~ 70 DEG C; Further preferably, temperature of reaction 65 ~ 70 DEG C.
Preferred version of the present invention, wherein, in step (C), system alkali regulates pH, and alkali is selected from mineral alkali and organic bases, preferred mineral alkali, further potassium bicarbonate, salt of wormwood, sodium bicarbonate, sodium carbonate, sodium hydroxide or potassium hydroxide.
Preferred version of the present invention, wherein, in step (C) system, pH value is 8 ~ 10, preferably 8 ~ 9.
Preferred version of the present invention, wherein, in step (1), chlorination reagent is selected from oxalyl chloride.
Preferred version of the present invention, wherein, step (2) temperature of reaction is 65 ~ 120 DEG C, preferably 85 ~ 100 DEG C, preferably 90 ~ 100 DEG C further.
Preferred version of the present invention, wherein, step (2) temperature of reaction is 60 ~ 120 DEG C, preferably 80 ~ 100 DEG C, preferably 80 ~ 85 DEG C further.
The present invention monitors reaction process by HPLC, judges whether that reaction terminates.
The preparation method of easypro more glucose sodium provided by the present invention is particularly suited for the easypro more glucose sodium of industrial production.
By preparation method of the present invention prepare relax more glucose sodium intermediate formula (II) productive rate is high, purity is high, by the present invention prepare relax more glucose sodium intermediate formula (II) more further preparation to relax more glucose sodium, the productive rate obtained and purity higher.
Embodiment
Describe the beneficial effect of implementation process of the present invention and generation below by way of specific embodiment in detail, be intended to help reader to understand essence of the present invention and feature better, not as can the restriction of practical range to this case.
The structure of compound is determined by nucleus magnetic resonance (NMR) and/or mass spectrum (MS).
NMR displacement (δ) is with 10
-6(ppm) unit provides.
The mensuration of NMR is with (BrukerADVANCEIII400) nuclear magnetic resonance spectrometer, and measuring solvent is deuterated dimethyl sulfoxide (DMSO-d
6), deuterochloroform (CDCl
3), deuterated water (D
2o), deuterated methanol (CD
3oD), be inside designated as tetramethylsilane (TMS), chemical shift: s, unimodal; D, doublet; T, triplet; Q, quartet; M, multiplet.
Without specified otherwise, oxalyl chloride, thionyl chloride are bought in Chengdu section dragon chemical reagent; γ-cyclodextrin is bought in Nanjing Kang Manlin chemical industry Industrial Co., Ltd..
Without specified otherwise in embodiment, solution refers to the aqueous solution.
Room temperature is 20 DEG C ~ 30 DEG C.
Normal temperature is 15 ~ 25 DEG C.
DMF:N, dinethylformamide.
NaH: sodium hydride.
Embodiment 1
Complete (2-carboxy ethyl) thioether-γ-cyclodextrin of the full deoxidation of 6--6-(relax more glucose sodium)
The first step: perchloro γ-cyclodextrin (compound 2)
Added in the dry reaction still of 50L by the DMF (20L) of drying, use nitrogen replacement air, ice bath cools.At 0 ~ 5 DEG C, drip oxalyl chloride (3.916Kg), in dropping process, have gas and solid to produce, react more violent.Within 105 minutes, dropwise, continue stirring 0.5 hour.The γ-cyclodextrin (compound 1) (2Kg) of drying is dissolved in dry DMF (15L), is added dropwise in above-mentioned reaction system at 5 ~ 10 DEG C.Be warming up to 65 ~ 70 DEG C, continue reaction 85 hours, stopped reaction.Reaction solution is cooled to room temperature, join in frozen water (90L), regulate mixture ph to 8 ~ 9 with the sodium hydroxide solution of 5mol/L, have a large amount of solid to separate out, temperature of reaction is risen to normal temperature and continue stirring reaction 1 hour, suction filtration, filter cake washes with water (15L × 2), dry, obtains perchloro γ-cyclodextrin (compound 2) (2.12Kg, productive rate: 95%, HPLC:99.6%).
1HNMR(400MHz,DMSO-d
6):δ5.94(m,16H),4.99(d,8H),4.02(t,8H),3.84(dd,16H),3.63(dd,8H),3.41(m,16H)。
Second step: complete (2-carboxy ethyl) thioether-γ-cyclodextrin of the full deoxidation of 6--6-(relax more glucose sodium)
Under nitrogen atmosphere and ice bath, sodium hydride (1.647Kg, 60%) is added in dry DMF (25L).At 0 ~ 10 DEG C, drip DMF (1.6L) solution of 3-thiohydracrylic acid (2.05Kg), have gas to produce.Within 3 hours, dropwise, rise to normal temperature and continue stirring 1 hour.Drip DMF (15L) solution of perchloro γ-cyclodextrin (compound 2) (1.75Kg) under ice bath, within 30 minutes, dropwise, be warming up to 65 ~ 70 DEG C and continue reaction 38 hours.Reaction solution is cooled to room temperature, centrifugal, filter cake is added in ethanol (60L) and water (20L) mixed solvent and pulls an oar 1.5 hours, centrifugal, filter cake is added to N, pull an oar in the mixed solvent of dinethylformamide (20L) and water (8L), centrifugal, dry, obtain the more glucose sodium (2.57Kg that relaxes, productive rate: 97.5%, HPLC:97.7%).
1HNMR(400MHz,D
2O):δ5.16(d,8H),4.03(t,8H),3.92(t,8H),3.63(t,16H),3.16(dd,8H),3.00(t,8H),2.90(t,16H),2.51(t,16H)；
LC/MS/MSm/z:999.1[(M-2)/2]。
Embodiment 2
Complete (2-carboxy ethyl) thioether-γ-cyclodextrin of the full deoxidation of 6--6-(relax more glucose sodium)
The first step: perchloro γ-cyclodextrin (compound 2)
Join in the there-necked flask of the drying of 250mL by the DMF (75mL) of drying, nitrogen replacement, ice bath cools.At 0 ~ 5 DEG C, drip thionyl chloride (29.4g), within 30 minutes, dropwise, temperature is risen to normal temperature and continue stirring reaction 1 hour.At 5 ~ 10 DEG C, dry γ-cyclodextrin (compound 1) (10g) is added in reaction system, be warming up to 70 ~ 75 DEG C of reactions 24 hours, reaction solution is cooled to room temperature, be evaporated to half reaction solution volume, residual solution is joined in frozen water (1.5L), mixed solution pH value to 8 ~ 9 are regulated with sodium hydroxide, a large amount of solid is had to separate out, temperature of reaction system is risen to stirring at normal temperature 0.5 hour, suction filtration, filter cake washes with water (100mL × 3), dry, obtain perchloro γ-cyclodextrin (compound 2) (10.9g, productive rate: 98%, HPLC:98%).
Second step: complete (2-carboxy ethyl) thioether-γ-cyclodextrin of the full deoxidation of 6--6-(relax more glucose sodium)
Under nitrogen atmosphere and ice bath, sodium hydride (6.78g, 60%) is added in dry DMF (100mL).At 0 ~ 5 DEG C, drip DMF (10mL) solution of 3-thiohydracrylic acid (8.17g), dropwise after 20 minutes, rise to normal temperature and continue stirring 1 hour.DMF (50mL) solution of perchloro γ-cyclodextrin (compound 2) (11.14g) is dripped under ice bath.Be warming up to 60 ~ 65 DEG C and continue reaction 14 hours.Reaction solution is cooled to room temperature, suction filtration, be added to by filter cake in ethanol (150mL) and water (50mL) mixed solvent and pull an oar, suction filtration, is added to N by filter cake, pull an oar in the mixed solvent of dinethylformamide (200mL) and water (80mL), suction filtration, filtration cakes torrefaction, obtains the more glucose sodium (15g that relaxes, productive rate: 90%, HPLC:98%).
Embodiment 3
The preparation of perchloro γ-cyclodextrin (compound 2)
The DMF (15L) of drying is added in the dry reaction still of 50L, uses nitrogen replacement air, be cooled with an ice bath.At 0 ~ 5 DEG C of temperature, drip oxalyl chloride (3.35Kg), within 110 minutes, dropwise, continue stirring 0.5 hour.The γ-cyclodextrin (compound 1) (2Kg) of drying is dissolved in dry DMF (10L), is added dropwise in above-mentioned reaction system at 5 ~ 10 DEG C.Be warming up to 65 ~ 70 DEG C, continue reaction 20 hours.Reaction solution is cooled to room temperature, join in frozen water (90L), regulate mixture ph to 8 ~ 9 with sodium hydroxide, have a large amount of solid to separate out, temperature of reaction is risen to normal temperature and continue stirring 1 hour, suction filtration, filter cake use water (15L) washs, dry, obtains perchloro γ-cyclodextrin (compound 2) (2.15Kg, productive rate: 96.5%, HPLC:99.6%).
Embodiment 4
The preparation of perchloro γ-cyclodextrin (compound 2)
The DMF (4L) of drying is added in the dry reaction still of 10L, uses nitrogen replacement air, be cooled with an ice bath.At 0 ~ 5 DEG C of temperature, drip oxalyl chloride (421mL), within 1.5 hours, dropwise, continue stirring 1 hour.The γ-cyclodextrin (compound 1) (400g) of drying is dissolved in dry DMF (3L), is added dropwise in above-mentioned reaction system at 5 ~ 10 DEG C.Be warming up to 60 ~ 65 DEG C, continue reaction 14 hours, stopped reaction.Reaction solution is cooled to room temperature, join in frozen water, regulate mixture ph to 8 ~ 9 with sodium hydroxide, have a large amount of solid to separate out, temperature of reaction is risen to normal temperature and continue stirring reaction 1 hour, suction filtration, filter cake use water (15L × 2) washs, dry, obtains perchloro γ-cyclodextrin (compound 2) (430g, productive rate: 96.5%, HPLC:99.9%).
Embodiment 5
The preparation of perchloro γ-cyclodextrin (compound 2)
Added by the DMF (250mL) of drying in dry four-hole boiling flask, nitrogen replacement, ice bath cools.0 ~ 5 DEG C drips oxalyl chloride (66.6g), in dropping process, has gas and solid to produce, reacts more violent.Within 20 minutes, finish, stir 1 hour.DMF (150mL) solution of 5 ~ 10 DEG C of droppings γ-cyclodextrin (compound 1) (20g, moisture 8 ~ 10%), finishes for 30 minutes.Be warming up to 60 ~ 65 DEG C of reactions 20 hours.Reaction solution is cooled to room temperature, join in frozen water (2L), regulate reacting liquid pH value to 8 ~ 9 with sodium hydroxide, have a large amount of solid to separate out, rise to normal temperature and continue stirring 1 hour, suction filtration, filter cake use water (500mL × 2) washs, and dries filter cake, obtains perchloro γ-cyclodextrin (compound 2) (22.21g, productive rate: 99.7%, HPLC:99.90%).
Embodiment 6
Prepared by the more glucose sodium that relaxes
Under nitrogen atmosphere and ice bath, sodium hydride (9.4g, 60%) is added in dry DMF (200mL).At 0 ~ 5 DEG C, drip 3-thiohydracrylic acid (11.74g), within 20 minutes, finish, rise to normal temperature and continue stirring 1 hour.DMF (100mL) solution of perchloro γ-cyclodextrin (compound 2) (10g) is dripped under ice bath.Be warming up to 80 ~ 85 DEG C and continue reaction 62 hours.Reaction solution is cooled to room temperature, suction filtration, be added to by filter cake in ethanol (300mL) and water (100mL) mixed solvent and pull an oar, suction filtration again, is added to N by filter cake, pull an oar in the mixed solvent of dinethylformamide (250mL) and water (100mL), suction filtration, dry, obtain the more glucose sodium (14.8g that relaxes, productive rate: 98.6%, HPLC:99.0%).
Embodiment 7
Prepared by the more glucose sodium that relaxes
Under nitrogen atmosphere and ice bath, sodium hydride (9.4g, 60%) is added in dry DMF (200mL).At 0 ~ 10 DEG C, drip 3-thiohydracrylic acid (11.74g), within 20 minutes, finish, rise to normal temperature and continue stirring 1 hour.DMF (100mL) solution of perchloro γ-cyclodextrin (compound 2) (10g) is dripped under ice bath.Be warming up to 115 ~ 120 DEG C and continue reaction 19 hours.Reaction solution is cooled to room temperature, suction filtration, be added to by filter cake in ethanol (300mL) and water (100mL) mixed solvent and pull an oar, suction filtration again, is added to N by filter cake, pull an oar in the mixed solvent of dinethylformamide (250mL) and water (100mL), suction filtration, dry, obtain the more glucose sodium (14.6g that relaxes, productive rate: 97.3%, HPLC:98.5%).
Embodiment 8
Prepared by the more glucose sodium that relaxes
Under nitrogen atmosphere and ice bath, sodium hydride (9.4g, 60%) is added in dry DMF (200mL).At 0 ~ 10 DEG C, drip 3-thiohydracrylic acid (11.74g), within 20 minutes, finish, rise to normal temperature and continue stirring 1 hour.DMF (100mL) solution of perchloro γ-cyclodextrin (compound 2) (10g) is dripped under ice bath.Be warming up to 95 ~ 100 DEG C and continue reaction 19 hours.Reaction solution is cooled to room temperature, suction filtration, be added to by filter cake in ethanol (300mL) and water (100mL) mixed solvent and pull an oar, suction filtration again, is added to N by filter cake, pull an oar in the mixed solvent of dinethylformamide (250mL) and water (100mL), suction filtration, dry, obtain the more glucose sodium (14.2g that relaxes, productive rate: 94.6%, HPLC:99.8%).
Claims (11)
1. a preparation method for the easypro more glucose sodium intermediate of formula (II), it is characterized in that, described method comprises formula (I) compound and chlorination reagent carries out chlorination:
Wherein, chlorination reagent is selected from thionyl chloride or oxalyl chloride;
2. preparation method according to claim 1, is characterized in that, described method comprises:
(A), under rare gas element atmosphere, chlorination reagent is added drop-wise in DMF at-10 ~ 20 DEG C;
(B) mixture of formula (I) compound and DMF is dropped in step (A) reaction system, be warming up to 50 ~ 100 DEG C of reactions;
(C) step (B) reaction system is cooled, join in frozen water, with alkali regulation system solution to alkalescence, separate out solid, filter and obtain formula (II) compound.
3. the preparation method according to claims 1 or 2, is characterized in that, described chlorination reagent is selected from oxalyl chloride.
4. preparation method according to claim 2, is characterized in that, in step (B), temperature of reaction is 60 ~ 70 DEG C.
5. preparation method according to claim 2, is characterized in that, in step (C), alkali is selected from mineral alkali.
6. preparation method according to claim 5, is characterized in that, in step (C), mineral alkali is selected from saleratus, salt of wormwood, sodium bicarbonate, sodium carbonate, sodium hydroxide or potassium hydroxide.
7. preparation method according to claim 2, is characterized in that, in step (C), system solution pH value is 8 ~ 10.
8. a preparation method for easypro more glucose sodium, it is characterized in that, described method comprises the following steps:
(1) formula (I) compound and chlorination reagent are obtained by reacting formula (II) compound:
Wherein, chlorination reagent is selected from thionyl chloride or oxalyl chloride;
(2) formula (II) compound and 3-thiohydracrylic acid react and prepare the more glucose sodium that relaxes:
9. method according to claim 8, is characterized in that, in step (1), chlorination reagent is selected from oxalyl chloride.
10. method according to claim 8, is characterized in that, step (2) temperature of reaction is 60 ~ 120 DEG C.
11. methods according to claim 10, is characterized in that, step (2) temperature of reaction is 80 ~ 100 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510241131.3A CN105273095A (en) | 2014-05-28 | 2015-05-13 | Preparation method for sugammadex and intermediates thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410230465 | 2014-05-28 | ||
| CN2014102304656 | 2014-05-28 | ||
| CN201510241131.3A CN105273095A (en) | 2014-05-28 | 2015-05-13 | Preparation method for sugammadex and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105273095A true CN105273095A (en) | 2016-01-27 |
Family
ID=55142986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510241131.3A Pending CN105273095A (en) | 2014-05-28 | 2015-05-13 | Preparation method for sugammadex and intermediates thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105273095A (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106565858A (en) * | 2016-10-13 | 2017-04-19 | 王炳永 | Purification method for sugammadex sodium |
| WO2017089966A1 (en) | 2015-11-25 | 2017-06-01 | Fresenius Kabi Antiinfectives S.R.L. | An improved process for the preparation of sugammadex and its intermediates |
| WO2017163165A1 (en) | 2016-03-22 | 2017-09-28 | Fresenius Kabi Anti-Infectives S.r.l. | An improved process for the preparation of sugammadex |
| CN107686530A (en) * | 2017-10-16 | 2018-02-13 | 河北坤安药业有限公司 | A kind of synthetic method for the more glucose sodium that relaxes |
| WO2018036353A1 (en) * | 2016-08-24 | 2018-03-01 | 王炳永 | Sugammadex sodium refining method |
| CN108047354A (en) * | 2017-11-07 | 2018-05-18 | 山东达冠医药科技有限公司 | A kind of high-purity is relaxed the more preparation of glucose sodium and its intermediate and purification process |
| CN109021148A (en) * | 2017-06-08 | 2018-12-18 | 天津科伦药物研究有限公司 | A method of preparing the more glucose sodium that relaxes |
| CN109593143A (en) * | 2018-12-29 | 2019-04-09 | 博瑞生物医药（苏州）股份有限公司 | A kind of more glucose sodium that relaxes prepares the purification process of intermediate |
| CN109988256A (en) * | 2019-03-26 | 2019-07-09 | 北京晨光同创医药研究院有限公司 | A kind of preparation method of relax more glucose sodium and its intermediate |
| US10385142B2 (en) | 2017-01-23 | 2019-08-20 | Scinopharm Taiwan, Ltd. | Method for preparing sugammadex sodium |
| US10414830B2 (en) | 2015-11-25 | 2019-09-17 | Fresenius Kabi Ipsum S.R.L. | Crystalline forms of per-chloro-γ-cyclodextrines |
| CN110818817A (en) * | 2019-08-29 | 2020-02-21 | 常州亚邦制药有限公司 | Sugammadex sodium diphenyl phosphine oxide derivative impurity and preparation method thereof |
| CN111615522A (en) * | 2017-11-27 | 2020-09-01 | 摩迪康公司 | Process for the synthesis of cyclodextrin derivatives |
| CN112830981A (en) * | 2019-11-22 | 2021-05-25 | 北京泰德制药股份有限公司 | Intermediate of sugammadex sodium and preparation method thereof |
| CN114181331A (en) * | 2020-09-15 | 2022-03-15 | 鲁南制药集团股份有限公司 | Synthesis method of sugammadex intermediate |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0641203A (en) * | 1992-07-24 | 1994-02-15 | Toppan Printing Co Ltd | Cyclodextrin derivative and its production |
| CN101331181A (en) * | 2005-10-31 | 2008-12-24 | 健康品牌有限公司 | Methods for chlorinating sucrose-6-ester |
| WO2012025937A1 (en) * | 2010-08-25 | 2012-03-01 | Ramamohan Rao Davuluri | Improved process for preparation of sugammadex |
-
2015
- 2015-05-13 CN CN201510241131.3A patent/CN105273095A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0641203A (en) * | 1992-07-24 | 1994-02-15 | Toppan Printing Co Ltd | Cyclodextrin derivative and its production |
| CN101331181A (en) * | 2005-10-31 | 2008-12-24 | 健康品牌有限公司 | Methods for chlorinating sucrose-6-ester |
| WO2012025937A1 (en) * | 2010-08-25 | 2012-03-01 | Ramamohan Rao Davuluri | Improved process for preparation of sugammadex |
Non-Patent Citations (1)
| Title |
|---|
| NIRANJAN THOTA等: "Reaction of carbohydrates with Vilsmeier reagent: a tandem selective chloro O-formylation of sugars", 《ORGANIC & BIOMOLECULAR CHEMISTRY》 * |
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017089966A1 (en) | 2015-11-25 | 2017-06-01 | Fresenius Kabi Antiinfectives S.R.L. | An improved process for the preparation of sugammadex and its intermediates |
| US10414829B2 (en) | 2015-11-25 | 2019-09-17 | Fresenius Kabi Ipsum S.R.L. | Process for the preparation of sugammadex and its intermediates |
| US10414830B2 (en) | 2015-11-25 | 2019-09-17 | Fresenius Kabi Ipsum S.R.L. | Crystalline forms of per-chloro-γ-cyclodextrines |
| EP3733717A3 (en) * | 2016-03-22 | 2020-12-30 | Fresenius Kabi iPSUM S.r.l. | An improved process for the preparation of sugammadex |
| WO2017163165A1 (en) | 2016-03-22 | 2017-09-28 | Fresenius Kabi Anti-Infectives S.r.l. | An improved process for the preparation of sugammadex |
| CN108779186B (en) * | 2016-03-22 | 2021-07-13 | 费森尤斯卡比依普莎姆有限责任公司 | Improved method for preparing sugammadex |
| US10577433B2 (en) | 2016-03-22 | 2020-03-03 | Fresenius Kabi Ipsum S.R.L. | Process for the preparation of sugammadex |
| CN108779186A (en) * | 2016-03-22 | 2018-11-09 | 费森尤斯卡比依普莎姆有限责任公司 | A kind of improved method for preparing the more glucose that relaxes |
| EP3433285B1 (en) * | 2016-03-22 | 2020-06-03 | Fresenius Kabi iPSUM S.r.l. | An improved process for the preparation of sugammadex |
| JP2019510128A (en) * | 2016-03-22 | 2019-04-11 | フレゼニウス カビ イプスム エス．アール．エルＦｒｅｓｅｎｉｕｓ Ｋａｂｉ Ｉｐｓｕｍ Ｓ．Ｒ．Ｌ． | Improved process for the preparation of Sugamadex |
| WO2018036353A1 (en) * | 2016-08-24 | 2018-03-01 | 王炳永 | Sugammadex sodium refining method |
| KR20190032421A (en) * | 2016-08-24 | 2019-03-27 | 빙용 왕 | Purification method of sodium sugammadex |
| KR102197101B1 (en) | 2016-08-24 | 2020-12-31 | 허페이 보스크 팜테크 컴퍼니 리미티드 | How to purify sodium sugarmadex |
| US10941219B2 (en) | 2016-08-24 | 2021-03-09 | Hefei Bosikc Pharmtech Co., Ltd. | Method for refining sugammadex sodium |
| CN107778383A (en) * | 2016-08-24 | 2018-03-09 | 王炳永 | A kind of process for purification for the more glucose sodium that relaxes |
| CN107778383B (en) * | 2016-08-24 | 2020-03-10 | 王炳永 | Refining method of sugammadex sodium |
| CN106565858B (en) * | 2016-10-13 | 2019-02-19 | 王立燕 | A kind of purification process for the more glucose sodium that relaxes |
| CN106565858A (en) * | 2016-10-13 | 2017-04-19 | 王炳永 | Purification method for sugammadex sodium |
| US10385142B2 (en) | 2017-01-23 | 2019-08-20 | Scinopharm Taiwan, Ltd. | Method for preparing sugammadex sodium |
| CN109021148B (en) * | 2017-06-08 | 2020-11-10 | 天津科伦药物研究有限公司 | Method for preparing sugammadex sodium |
| CN109021148A (en) * | 2017-06-08 | 2018-12-18 | 天津科伦药物研究有限公司 | A method of preparing the more glucose sodium that relaxes |
| CN107686530A (en) * | 2017-10-16 | 2018-02-13 | 河北坤安药业有限公司 | A kind of synthetic method for the more glucose sodium that relaxes |
| CN108047354A (en) * | 2017-11-07 | 2018-05-18 | 山东达冠医药科技有限公司 | A kind of high-purity is relaxed the more preparation of glucose sodium and its intermediate and purification process |
| CN111615522A (en) * | 2017-11-27 | 2020-09-01 | 摩迪康公司 | Process for the synthesis of cyclodextrin derivatives |
| CN109593143A (en) * | 2018-12-29 | 2019-04-09 | 博瑞生物医药（苏州）股份有限公司 | A kind of more glucose sodium that relaxes prepares the purification process of intermediate |
| CN109593143B (en) * | 2018-12-29 | 2021-02-09 | 博瑞生物医药（苏州）股份有限公司 | Purification method for preparing intermediate from sugammadex sodium |
| CN109988256A (en) * | 2019-03-26 | 2019-07-09 | 北京晨光同创医药研究院有限公司 | A kind of preparation method of relax more glucose sodium and its intermediate |
| CN110818817A (en) * | 2019-08-29 | 2020-02-21 | 常州亚邦制药有限公司 | Sugammadex sodium diphenyl phosphine oxide derivative impurity and preparation method thereof |
| CN112830981A (en) * | 2019-11-22 | 2021-05-25 | 北京泰德制药股份有限公司 | Intermediate of sugammadex sodium and preparation method thereof |
| CN114181331A (en) * | 2020-09-15 | 2022-03-15 | 鲁南制药集团股份有限公司 | Synthesis method of sugammadex intermediate |
| CN114181331B (en) * | 2020-09-15 | 2023-07-14 | 鲁南制药集团股份有限公司 | Synthesis method of sodium sugammadex intermediate |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105273095A (en) | Preparation method for sugammadex and intermediates thereof | |
| CN104761456A (en) | Preparation method of 3-amino-1-adamantanol | |
| CN101880292B (en) | Cucurbit[n]uril metal-organic framework polymer in multilayer porous reticular structure and synthesis method thereof | |
| CN104557921B (en) | The synthetic method of pyrroloquinoline quinone | |
| CN108033947A (en) | Treat the preparation method that non-small cell lung cancer drug Ai Li replaces Buddhist nun | |
| CN109810031A (en) | The preparation method of Fei Luokao former times intermediate | |
| CN104803978B (en) | A kind of preparation method of esomeprazole magnesium | |
| CN111454164A (en) | Preparation method of terbutaline sulfate | |
| CN103044272B (en) | Preparation method of 4-nitroso-N-ethyl-N-hydroxyethyl aniline | |
| CN105175316B (en) | A kind of method for preparing laxative picosulfate sodium | |
| CN101575301B (en) | Preparation method of 2-amino-5-chlorobenzamide | |
| CN104402813B (en) | Novel method for synthesizing sorafenib | |
| CN103288693A (en) | Method for preparing 1-thiol pyrene and intermediate compound thereof | |
| CN103709174A (en) | One-step synthesis method of 6-bromo-3H-oxazolo [4,5-b] pyridine-2-ketone | |
| CN103539728A (en) | Synthesis method of lansoprazole drug intermediate chloromethyl pyridine derivative | |
| CN102702224A (en) | Preparation method of type I clopidogrel hydrogen sulfate | |
| CN102675148A (en) | Preparation method of hydroxybenzyl cyanide | |
| CN102516311A (en) | Preparation method of miriplatin hydrate | |
| CN102584688B (en) | Preparing method of 2,6-dichloro-3-nitropyridine | |
| CN110016029A (en) | A kind of preparation method of fluoro- 1H- pyrrolo- [2,3-b] pyridine-2-carboxylic acids of 3- | |
| CN109705024A (en) | 1,3- bipyridyl -2,4- bis- (4- pyridine vinyl naphthalene) cyclobutane and preparation method thereof | |
| CN108129536A (en) | A kind of preparation method of Dexamethasone Intermediate | |
| CN103030580A (en) | Preparation method of lapatinib intermediate | |
| CN102875568B (en) | The method of the pure crystal formation I of preparation (+)-(S)-SR-25990C | |
| CN105541635A (en) | Fullerol poly-nitrate and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160127 |
|
| RJ01 | Rejection of invention patent application after publication |