CN105243298A - Pancreatic cancer related cancer gene mutation information collection and analysis system and analysis method - Google Patents
Pancreatic cancer related cancer gene mutation information collection and analysis system and analysis method Download PDFInfo
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Abstract
The invention relates to a pancreatic cancer related cancer gene mutation information collection and analysis system and an analysis method. The information collection and analysis system comprises an information collection module, a user module, a database module, a gene risk analysis module and a report output module. The method is used for collecting pancreatic cancer related cancer gene mutation information and carrying out pancreatic cancer risk evaluation on the check data of users. According to the pancreatic cancer related cancer gene mutation information collection and analysis system, related gene mutation information can be comprehensively collected and the correctness of pancreatic cancer risk evaluation of the patients can be improved, so that the early discovery and early treatment of pancreatic cancer is realized and the survival rate of the patients is improved.
Description
Technical field
The invention belongs to biomedical sector, relate to a kind of cancer of pancreas Related oncogene abrupt information collection analysis system and analytical approach.
Background technology
Cancer of pancreas is alimentary canal kinds of tumor, early diagnosis difficulty and poor prognosis, and its aggressive is strong, and grade of malignancy is high, and Resection Rate is low, and five year survival rate is extremely low.Its onset is hidden, and lacks typical clinical symptom, become the study hotspot of oncologist both at home and abroad at present, the early diagnosis of cancer of pancreas and early treatment are the keys improving and improve cancer of pancreas prognosis.
Cancer of pancreas is a kind of genetic variability disease, current research proves that being permitted polygenic sudden change develops relevant with the generation of cancer of pancreas, as KRAS, SMAD4, CDKN2A, TP53, ZIP4, PDX-1 gene etc., but the diagnosis of independent gene diagnosis or a small amount of assortment of genes is often accurately slightly not high, still lacks a kind of effective diagnosis of pancreatic cancer or Forecasting Methodology at present.
Summary of the invention
In order to make up the deficiencies in the prior art, the information analytic system that the object of the present invention is to provide a kind of cancer of pancreas Related oncogene to suddenly change and analytical approach, described Information Collection System incorporates the abrupt information of the cancer of pancreas Related oncogene of report at present, can predict that patient suffers from the risk of cancer of pancreas, for doctor provides diagnosis reference, thus realize early finding early treatment, improve the survival rate of patient.
To achieve these goals, the present invention adopts following technical scheme:
The invention provides the information analytic system of a kind of cancer of pancreas Related oncogene sudden change, described information analytic system comprises: information collection module 1, line module 2, database module 3, gene venture analysis module 4 and report output module 5.
Described information collection module 1 comprises database side openning module 11, data retrieval submodule 12, data analysis submodule 13, data transmission module 14, Data Update submodule 15.
The interface that described line module 2 uses for user, this interface realizes the mutual of user and system, and accepts the result from report output module.
Described database module 3 comprises normal data library module 31 and data to be tested library module 32.Normal data library module 31 is used for storing the gene mutation data of the gene mutation data of the cancer of pancreas made a definite diagnosis and the cancer of pancreas from each database; Data to be tested storehouse submodule 32 is used for storing the gene analysis data of non-patient diagnosed;
Described gene venture analysis module 4 comprises diagnostic rule module 41, P module 42 and report generation submodule 43.
Described report output module 5 be used to store from gene venture analysis module 4 data and output to line module 2.
Further, described database side openning module 11 is connected with each database, and described database comprises Database in English and Chinese database.Described Database in English comprises NCBI, nature, science etc., and described Chinese database comprises incomparably, knows net etc.
Further, described Data Update submodule 15 is connected with data retrieval submodule 12, for sending instruction, opens the information task of a new round.
Further, described report output module 5 comprises healthy comprehensive assessment reporting unit 51 and medical science suggestion reporting unit 52, for healthy comprehensive assessment report and the medical science suggestion report of store patient.
The invention provides the method for a kind of above-mentioned information analytic system collection analysis cancer of pancreas Related oncogene sudden change, described method comprises the following steps:
1) described information collection module 1 collects information, comprises the gene mutation data of the gene mutation data of the cancer of pancreas made a definite diagnosis and the cancer of pancreas from each database;
2) described line module 2 collects user related information, and uploads to described information collection module 1;
3) by the data upload in described information collection module 1 to the corresponding standard database submodule 31 of described database module 3 or data to be tested storehouse submodule 32;
4) described gene venture analysis module 4 transfers the data in described database module 3, and carries out pancreatic cancer risk assessment to data to be tested;
5) risk evaluation result is outputted to described report output module 5;
6) by the reporting feedback in described report output module 5 to user, user is known, and patient suffers from the probability of cancer of pancreas, thus vigilance to some extent, realizes the early treatment of cancer of pancreas.
Above-mentioned steps 1) collection of information comprises the following steps:
1) described database side openning module 11 connects each database;
2) keyword is set in described data retrieval submodule 12, automatically the relevant information of each database of retrieval;
3) described data analysis submodule 13 pairs of steps 2) in information extract further, remove the information of redundancy, information needed carried out the unification of form;
4) described data transmission module 14 connects described database module 3, by from step 3) information upload to described database module 3;
5) described Data Update submodule 15 regularly sends instruction, repeats step 1)-4), with more new data.
Described user related information uploads to described data retrieval submodule 12, then carries out data analysis and transmission uploads to described database module 3.If relevant information is from the Pancreas cancer patients made a definite diagnosis, upload to described standard database submodule 31, if relevant information is from ND patient, upload to described data to be tested storehouse submodule 32.
The concrete steps that above-mentioned gene venture analysis module 4 gene carries out pancreatic cancer risk assessment are as follows:
1) data analysis during described diagnostic rule submodule 41 transfers in described database module 3 standard database submodule 31, generates the diagnostic rule of cancer of pancreas, suffers from the standard of pancreatic cancer risk as diagnosis patient;
2) data during described P submodule 42 transfers in described database module 3 data to be tested storehouse submodule 32, the diagnostic rule generated with described diagnostic rule submodule 41 suffers from the probability of cancer of pancreas for standard analysis patient;
3) described report generation submodule 43 accepts the data through described P submodule 42 analysis, generates healthy comprehensive assessment report and/or medical science suggestion report.
Advantage of the present invention and beneficial effect:
The collection analysis system energy automatic updating data storehouse of the cancer of pancreas Related oncogene abrupt information in the present invention, make database information more comprehensively, and then the diagnostic rule of gene venture analysis module is more optimized, thus improve the accuracy rate of pancreatic cancer risk assessment.
The collection analysis system synthesis of the cancer of pancreas Related oncogene abrupt information in the present invention reported with the information of the Cancer-Related gene mutation of pancreas, more fully can analyze the inspection data of patient, improve diagnosis.Thus the early detection of cancer of pancreas can be realized, and then carry out early treatment, improve the survival rate of patient.
Accompanying drawing explanation
Fig. 1 shows the collection analysis system of cancer of pancreas Related oncogene abrupt information;
Fig. 2 shows the structural drawing of information collection module;
Concrete embodiment
Below in conjunction with drawings and Examples, the present invention is further detailed explanation, and following examples are only not used in for illustration of the present invention and limit the scope of the invention.
The information analytic system of embodiment 1 one kinds of cancer of pancreas Related oncogene sudden changes
An information analytic system for cancer of pancreas Related oncogene sudden change, comprising: information collection module 1, line module 2, database module 3, gene venture analysis module 4 and report output module 5.
Information collection module 1 comprises database side openning module 11, data retrieval submodule 12, data analysis submodule 13, data transmission module 14, Data Update submodule 15.Database module 3 comprises normal data library module 31 and data to be tested library module 32.Database side openning module 11 is connected with each database, and described database comprises Database in English and Chinese database.Wherein, Database in English comprises NCBI, nature, science etc., and Chinese database comprises incomparably, knows net etc.Data retrieval module 12 is by setting keyword, the relevant information of each database of automatic retrieval, data analysis module 13 analyzes the data from data retrieval module 12, data are extracted further, remove the data of redundancy, the form of the data required for unification, then uploads to the normal data library module 31 of database module 3 through data transmission module 14.Data update module 15 regularly can send instruction, starts the task of data retrieval, analysis, with more new database.
Data retrieval module 12 can also accept the data from line module 2, by the keyword of setting, retrieve relevant information and upload to data analysis module 13 and further analyze processing, the data generating consolidation form upload to database module 3 through data transmission module 14.If data are from the Pancreas cancer patients made a definite diagnosis, upload to normal data library module 31, if data are from ND patient, upload to data to be tested library module 32.
Gene venture analysis module 4 comprises diagnostic rule module 41, P module 42 and report generation module.Diagnostic rule module 41 data analysis transferred in normal data library module 31 generates the rule for predicting pancreatic cancer risk; P module 42 transfers the data in data to be tested library module 32, the rule generated with diagnostic rule module 41 is for standard, to data analysis to be detected, calculate the probability that corresponding patient suffers from cancer of pancreas, and the data of generation are transferred to report generation module 43 generate analysis report.
Report output module 5 comprises medical science suggestion report 51 and 52 two unit are reported in healthy comprehensive assessment, report output module 5 stores report from report generation module 43 and report output to line module 2, for doctor provides diagnosis reference, find early treatment with the morning realizing cancer of pancreas.
The collection analysis method of embodiment 2 one kinds of cancer of pancreas Related oncogene abrupt informations
A collection analysis method for cancer of pancreas Related oncogene abrupt information, the method is realized by the information analytic system implemented described in 1, and its concrete steps are as follows:
1) information collection module 1 collects information, comprises the gene mutation data of the gene mutation data of the cancer of pancreas made a definite diagnosis and the cancer of pancreas from each database.Concrete steps comprise a. database side openning module 11 and connect each database; B. keyword is set in data retrieval submodule 12, automatically the relevant information of each database of retrieval; C. the information in data analysis submodule 13 couples of step b is extracted further, removes the information of redundancy, information needed is carried out the unification of form; D. data transmission module 14 connection data library module, by from step 3) information upload to database module 3; E. Data Update submodule 15 regularly sends instruction, repeats step 1)-4), with more new data.
2) line module 2 collects user related information, and uploads to information collection module 1.Data retrieval module 12 in information collection module 1 accepts the relevant information from line module 2 and retrieves, then upload data to data analysis module 13 and further analyze processing, the data generating consolidation form upload to database module 3 through data transmission module 14.
3) by the data upload in information collection module 1 to the corresponding normal data library module 31 of database module 3 or data to be tested library module 32.
4) data in gene venture analysis module 4 called data library module 3, and pancreatic cancer risk assessment is carried out to data to be tested.Concrete steps comprise: the data analysis of the standard database submodule 31 in a. diagnostic rule submodule 41 called data library module 3, generate the diagnostic rule of cancer of pancreas, suffer from the standard of pancreatic cancer risk as diagnosis patient; The data of the data to be tested storehouse submodule 32 b. in P submodule 42 called data library module 3, with diagnostic rule submodule 41 for standard analysis patient suffers from the probability of cancer of pancreas; C. report generation submodule 43 pieces accepts the data through P submodule 42 analysis, generates healthy comprehensive assessment report and/or medical science suggestion report.
5) risk evaluation result is outputted to report output module 5;
6) by the reporting feedback in report output module 5 to line module 2, user is known, and patient suffers from the probability of cancer of pancreas, thus vigilance to some extent, realizes the early stage diagnosis and treatment of cancer of pancreas.
The explanation of above-described embodiment is only used to understand technical scheme of the present invention.It should be pointed out that for the person of ordinary skill of the art, under the premise without departing from the principles of the invention, can carry out some improvement and modification to the present invention, these improve and modify and also will fall in the protection domain of the claims in the present invention.
Claims (7)
1. the information analytic system of a cancer of pancreas Related oncogene sudden change, it is characterized in that, described Information Collection System comprises information collection module (1), line module (2), database module (3), gene venture analysis module (4), report output module (5);
Described information collection module comprises (1): database side openning module (11), data retrieval submodule (12), data analysis submodule (13), data transmission module (14), Data Update submodule (15);
The interface that described line module (2) uses for user, this interface realizes the mutual of user and system, and accepts the result from report output module;
Described database module (3) comprises standard database submodule (31) and data to be tested storehouse submodule (32), and standard database submodule (31) is used for storing the gene mutation data of the gene mutation data of the cancer of pancreas made a definite diagnosis and the cancer of pancreas from each database; Data to be tested storehouse submodule (32) is used for storing the gene analysis data of non-patient diagnosed;
Described gene venture analysis module (4) comprises diagnostic rule submodule (41), P submodule (42), report generation submodule (43);
Described report output module (5) be used to store from gene venture analysis module (4) data and output to line module (2).
2. information analytic system according to claim 1, is characterized in that, described database side openning module (11) is connected with each database, and described database comprises Database in English and Chinese database.
3. information analytic system according to claim 1, is characterized in that, described Data Update submodule (15) is connected with data retrieval submodule (12), for sending instruction, opens the information task of a new round.
4. information analytic system according to claim 1, is characterized in that, described report output module (5) comprises healthy comprehensive assessment reporting unit (51) and medical science suggestion reporting unit (52).
5. a method for the information analytic system collection analysis cancer of pancreas Related oncogene sudden change described in any one of claim 1-4, it is characterized in that, described method comprises the following steps:
1) described information collection module (1) collects information, comprises the gene mutation data of the gene mutation data of the cancer of pancreas made a definite diagnosis and the cancer of pancreas from each database;
2) described line module (2) collects user related information, and uploads to the data retrieval submodule (12) in described information collection module (1);
3) by the data upload in described information collection module (1) to the corresponding standard database submodule (31) in described database module (3) or data to be tested storehouse submodule (32);
4) described gene venture analysis module (4) transfers the data in described database module (3), and carries out pancreatic cancer risk assessment to data to be tested;
5) risk evaluation result is outputted to described report output module (5);
6) by the reporting feedback in described report output module (5) to user, user is known, and patient suffers from the probability of cancer of pancreas, thus vigilance to some extent, realizes the early stage diagnosis and treatment of cancer of pancreas.
6. method according to claim 5, is characterized in that, described step 1) collection of information comprises the following steps:
1) described database side openning module (11) connects each database;
2) setting keyword in described data retrieval submodule (12), the automatically relevant information of each database of retrieval;
3) described data analysis submodule (13) is to step 2) in information extract further, remove the information of redundancy, information needed carried out the unification of form;
4) described data transmission module (14) connects described database module (3), by from step 3) information upload to described database module (3);
5) described Data Update submodule (15) regularly sends instruction, repeats step 1)-4), with more new data.
7. method according to claim 5, is characterized in that, described step 4) comprise the following steps:
1) described diagnostic rule submodule (41) transfers the data analysis of the standard database submodule (31) in described database module (3), generate the diagnostic rule of cancer of pancreas, suffer from the standard of pancreatic cancer risk as diagnosis patient;
2) described P submodule (42) transfers the data in data to be tested storehouse submodule (32) in described database module (3), is the probability that standard analysis patient suffers from cancer of pancreas with the diagnostic rule that described diagnostic rule submodule (41) generates;
3) data analyzed through described P submodule (42) of described report generation submodule (43) acceptance, generate healthy comprehensive assessment report and/or medical science suggestion report.
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| CN106874647A (en) * | 2017-01-06 | 2017-06-20 | 吴安华 | A kind of Gliblastoma patient survival forecasting system |
| CN107315898A (en) * | 2016-04-26 | 2017-11-03 | 联邦应用基因股份有限公司 | The health risk high in the clouds analysis system of integrator gene information and the lifestyle day after tomorrow |
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