CN105232956A - Medicine for treating lung cancer merged dyspnea - Google Patents

Abstract

The invention provides medicine for treating lung cancer merged dyspnea. The medicine is prepared from rhizoma acori graminei, radix angelicae, golden cypress, asarum, centipeda minima, leaves of negundo chastetree, cordyceps sinensis, burdock, fritillaria cirrhosa, caulis spatholobi, tabasheer, sculellaria barbata, ginseng, liriope spicata, solanum lyratum, sealwort, saururus chinensis, galla chinensis and rhizoma panacis majoris. The medicine is used in cooperation with western medicine, a good treatment effect can be achieved, the use amount of the western medicine is reduced, the problems of resistance and medicine toxicity accumulation of the western medicine are solved, and the price is low.

Description

Treatment pulmonary carcinoma merges dyspneic medicine

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to one and treat pulmonary carcinoma and merge dyspneic medicine.

Background technology

Patients with lung cancer case fatality rate is higher, and chemotherapy is the Main Means for the treatment of, and dyspnea is the comparatively serious complication of patients with lung cancer, can directly bring out patient and respiratory failure occurs, increase the weight of the state of an illness.Easily there is dyspnea symptom in patients with lung cancer clinically, and the lung cancer patient of 10% ~ 15% has dyspnea when AD, and the patient of 65% occurs dyspnea symptom in ill process, and 70% Patients with Advanced Lung Cancer exists dyspnea symptom.Dyspnea is not only a symptom of respiratory disorder, also relates to the interactional impacts of many factors such as health, psychology, emotion and function simultaneously.Causing dyspneic reason complicated, is often multifactor causing, may with cancer directly, indirectly, treat and related complication four aspect factor relevant.

(1) caused by cancer: large bronchial obstruction and lung tissue are replaced restriction ventilation by cancerous tissue; Invasive cancer pleura, thoracic wall, every flesh restriction ventilation; Hydrothorax that cancer causes restriction ventilation, pulmonary carcinoma Malignant hydrothorax is malignant tumor invades and the Late manifestations of pleura; Lymphatic vessel inflammatory carninomatosis; The filling of mediastinum; Tumor causes pericardial effusion to weaken heart output; Cancer metastasis other organs causes a large amount of ascites and upper abdomen expansion to oppress lung tissue and heart, causes dyspnea; The spontaneous pneumothorax of pulmonary carcinoma, clinical more rare, account for 0.65% ~ 0.13% of all cases of lung cancer.

(2) relevant with cancer and (or) exhaustion situation: anemia, pulmonary atelectasis, pulmonary infarction, pneumonia, emphysema cachexia one anorexia syndrome and weakness (weak).

(3) pulmonary carcinoma and correlative factor treatment thereof cause: the pulmonary fibrosis that radiotherapy causes, pulmonary atelectasis etc.; Chemotherapy: as bleomycin A5, amycin and nitroso-group arteries and veins etc.; Associated medication therapies causes: patients with lung cancer Clinical practice analgesic etc. easily causes respiration inhibition.

(4) relevant with the complication patient's condition: superior vena cava syndrome, chronic obstructive disease of lung, asthma, heart failure, acidosis.

(5) psychology, emotional factor: indignation, impatience, frightened emotion and psychological factor consume oxygen and causes psychological burden, cause and increase the weight of dyspnea.

Doctor trained in Western medicine clinical treatment pulmonary carcinoma dyspnea, to clarify a diagnosis and treatment causes dyspneic reason for principle.To the reason that reversible or part reverse, give corresponding process as radiotherapy, hormone therapy, corticosteroid parahormone, bronchodilator, diuretic and other drug etc., and pleural drainage, abdomen puncture tapping art etc.Palliative treatment is given for irreversible patient.The drawback adopting western medicine to exist is that allergy, drug resistance, drug toxicity savings situation easily appears in patient, and medical expense is high.

The traditional Chinese medical science is often treated with the corresponding Chinese medical disease of the cardinal symptom of pulmonary carcinoma, as: lump in the right hypochondrium, cough, spitting of blood, chest pain etc.Pulmonary carcinoma dyspnea at Chinese medicine needleless to life name and description.Chinese medicine be it is generally acknowledged, and " dyspnea " namely refers to " asthma ".Can appear among a lot of disease, common as " the syndrome of dyspnea ", " asthma ".The Chinese traditional treatment of patients with lung cancer dyspnea symptom can be treated with reference to " the syndrome of dyspnea " and " asthma ".Adopt Chinese traditional treatment can overcome the problem of drug resistance existing for Western medicine and drug toxicity savings, and low price.

Summary of the invention

Technical problem to be solved by this invention is to provide one and treats pulmonary carcinoma and merge dyspneic Chinese medicine, it coordinates Western medicine to use, and can play good therapeutic effect, and reduce the use amount of Western medicine, overcome the problem of drug resistance existing for Western medicine and drug toxicity savings, low price.

For solving the problems of the technologies described above, the invention provides one to be used for the treatment of pulmonary carcinoma and to merge dyspneic medicine, its crude drug comprises Rhizoma Acori Graminei, the Radix Angelicae Dahuricae, Cortex Phellodendri, Herba Asari, Herba Centipedae, Folium Viticis Negundo, Cordyceps, Fructus Arctii, Bulbus Fritillariae Cirrhosae, Caulis Spatholobi, Concretio silicea Bambusae seu schizostachyi, Herba Scutellariae Barbatae, Radix Ginseng, Radix Liriopes, Herba Solani Lyrati, Rhizoma Polygonati, Rhizoma Saururi (Herba Saururi), Galla Chinensis and Rhizoma Panacis Majoris.

Wherein, in described medicine, the weight of each crude drug is specially Rhizoma Acori Graminei 15g ~ 25g, Radix Angelicae Dahuricae 35g ~ 45g, Cortex Phellodendri 20g ~ 30g, Herba Asari 15g ~ 25g, Herba Centipedae 20g ~ 30g, Folium Viticis Negundo 15g ~ 25g, Cordyceps 25g ~ 35g, Fructus Arctii 15g ~ 25g, Bulbus Fritillariae Cirrhosae 10g ~ 20g, Caulis Spatholobi 20g ~ 30g, Concretio silicea Bambusae seu schizostachyi 10g ~ 20g, Herba Scutellariae Barbatae 10g ~ 20g, Radix Ginseng 35g ~ 45g, Radix Liriopes 25g ~ 35g, Herba Solani Lyrati 5g ~ 15g, Rhizoma Polygonati 20g ~ 30g, Rhizoma Saururi (Herba Saururi) 15g ~ 25g, Galla Chinensis 20g ~ 30g and Rhizoma Panacis Majoris 15g ~ 25g.

Wherein, in described medicine, the weight of each crude drug is specially Rhizoma Acori Graminei 18g ~ 22g, Radix Angelicae Dahuricae 38g ~ 42g, Cortex Phellodendri 23g ~ 27g, Herba Asari 18g ~ 22g, Herba Centipedae 23g ~ 27g, Folium Viticis Negundo 18g ~ 22g, Cordyceps 28g ~ 32g, Fructus Arctii 18g ~ 22g, Bulbus Fritillariae Cirrhosae 13g ~ 17g, Caulis Spatholobi 23g ~ 27g, Concretio silicea Bambusae seu schizostachyi 13g ~ 17g, Herba Scutellariae Barbatae 13g ~ 17g, Radix Ginseng 38g ~ 42g, Radix Liriopes 28g ~ 32g, Herba Solani Lyrati 8g ~ 12g, Rhizoma Polygonati 23g ~ 27g, Rhizoma Saururi (Herba Saururi) 18g ~ 22g, Galla Chinensis 23g ~ 27g and Rhizoma Panacis Majoris 18g ~ 22g.

Wherein, in described medicine, the g of each crude drug is specially Rhizoma Acori Graminei 20g, Radix Angelicae Dahuricae 40g, Cortex Phellodendri 25g, Herba Asari 20g, Herba Centipedae 25g, Folium Viticis Negundo 20g, Cordyceps 30g, Fructus Arctii 20g, Bulbus Fritillariae Cirrhosae 15g, Caulis Spatholobi 25g, Concretio silicea Bambusae seu schizostachyi 15g, Herba Scutellariae Barbatae 15g, Radix Ginseng 40g, Radix Liriopes 30g, Herba Solani Lyrati 10g, Rhizoma Polygonati 25g, Rhizoma Saururi (Herba Saururi) 20g, Galla Chinensis 25g and Rhizoma Panacis Majoris 20g.

Wherein, medicine provided by the invention is injection.

Present invention also offers the preparation method of above-mentioned injection, it comprises:

The first step, each crude drug is cleaned respectively, pulverize, mix, by the alcoholic solution heating and refluxing extraction 2 times that determining alcohol is 70% ~ 80%, the time of each extraction is 1 ~ 2 hour, the weight ratio of the Chinese crude drug that alcoholic solution and this step mix is 5 ~ 8: 1, collect extracting solution, filter, concentrating filtrate to 60 DEG C of relative densities is the concentrated solution of 1.02 ~ 1.06, upper macroporous adsorptive resins, the weight of macroporous adsorbent resin is 1 ~ 3 times of the weight of the Chinese crude drug that this step mixes, with the alcoholic solution eluting that determining alcohol is 50% ~ 80%, the volume of described eluent is 5 ~ 20 times of macroporous adsorptive resins volume, collect eluent, concentrated except desolventizing, pulverize, obtain powder,

Second step, gets powder 10g ~ 20g that the first step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding.

Beneficial effect of the present invention:

The invention provides one to treat pulmonary carcinoma and merge dyspneic Chinese medicine, it coordinates Western medicine to use, and can play good therapeutic effect, and reduce the use amount of Western medicine, overcomes the problem of drug resistance existing for Western medicine and drug toxicity savings, low price.

Detailed description of the invention

The syndrome of dyspnea refers to due to impairment of dispersing and descending function of the lung, abnormal rising of lung-QI, or lung kidney cashier not normal and cause with dyspnea, even opening mouth and lifting shoulder due to dyspnea, flaring of alaenasi, can not put down a kind of common disease crouched as main manifestations.As a symptom, asthma can appear in multiple acute and chronic lysis.When breathing heavily the primary symptom of certain one-phase becoming these diseases, be namely called the syndrome of dyspnea.

The cause of disease of the syndrome of dyspnea has interior sense, wound not, pathogenesis have deficiency and excess point.The cause of disease: diseases caused by exogenous pathogenic factor are six climate exopathogens invasion and attack, and internal injury is by diet.Feelings will or labor are for caused by, prolonged illness.Pathogenesis: have that person for real, Yin Nakui is in lung, and a surname falls caused by mistake department; Naivete person belongs to empty, and because of the not main gas of lung, kidney loses to take the photograph to receive and forms.

Asthma is a kind of ictal rale, asthma disease, and with rapid breathing, between larynx, wheezing is principal character, the illness that ictal rale is out of breath, is called for short and roars.The traditional Chinese medical science thinks its main cause: latent phlegm retaining in the lung.

With the passing of time cough with asthma does not heal, loss lung qi, lung qi virtual loss, gas without lead, dereliction of duty falls in a surname, therefore sees cough with asthma, shortness of breath and low voice, and language is unable, defending gas leads in lung, insufficiency of lung-QI, and a surname sends out not normal, weakened defensive QI, folding mistake department, therefore see spontaneous perspiration, aversion to wind, normal easy catching a cold, weakened defensive QI, exopathogen is easily attacked, therefore treatment on QI invigorating tonifying the lung, hold concurrently clear intrinsic heat for controlling.

The invention provides one to be used for the treatment of pulmonary carcinoma and to merge dyspneic medicine, its crude drug comprises Rhizoma Acori Graminei, the Radix Angelicae Dahuricae, Cortex Phellodendri, Herba Asari, Herba Centipedae, Folium Viticis Negundo, Cordyceps, Fructus Arctii, Bulbus Fritillariae Cirrhosae, Caulis Spatholobi, Concretio silicea Bambusae seu schizostachyi, Herba Scutellariae Barbatae, Radix Ginseng, Radix Liriopes, Herba Solani Lyrati, Rhizoma Polygonati, Rhizoma Saururi (Herba Saururi), Galla Chinensis and Rhizoma Panacis Majoris.

Further preferably, described medicine is only prepared from by above-mentioned raw materials medicine.

Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, stomach warp, has refreshment of having one's ideas straightened out, effect of removing dampness to restore normal function of the stomach, and be used for the treatment of expectorant and cover clear key, coma is demented, dizzy, and insomnia is forgetful, tinnitus, retention of dampness in middle-JIAO, the cards such as abdominal distention.

The Radix Angelicae Dahuricae: latin name AngelicaeDahuricaeRadix, acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.

Cortex Phellodendri: latin name PhellodendriChinensisCortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus.

Herba Asari: latin name AsariRadixetRhizoma, acrid in the mouth, warm in nature, return lung, kidney channel, there is expelling wind and cold pain relieving, effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma caused by cold fluid-retention, nasal obstruction nasal sinusitis, wind-eye corneal nebula, deafness pharyngalgia, the cards such as aphtha halitosis.

Herba Centipedae: acrid in the mouth, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, eliminating phlegm and stopping cough, the effect of dissipating blood stasis for subsidence of swelling, for exterior syndrome due to wind-cold, nasal obstruction watery nasal discharge and nasal sinusitis, cough with copious phlegm, pertussis, the cards such as sore, carbuncle and painful swelling.

Folium Viticis Negundo: latin name ViticisNegundoFolium, acrid in the mouth; Bitter; Property is put down, and returns lung meridian, has removing dampness of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, effect of pain relieving, cures mainly Common Cold, cough, asthma; Stomachache; Stomachache; Heat-damp in summer dysentery; Beriberi swelling; Rubella pruritus; Tinea pedis; Acute mastitis swells and ache; The cards such as snake bite and insect sting.

Cordyceps: sweet in the mouth, property is put down, and enters lung, kidney channel, has kidney invigorating and YANG supporting, tonifying the lung is relievingd asthma, effect of hemostasis and phlegm, and the traditional Chinese medical science is thought, Cordyceps enters lung kidney two warp, can tonifying the lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint, weak after being ill, chronic cough is weak, phthisical cough expectorant blood, spontaneous sweatings etc., are unique a kind of Chinese medicine compositions that can balance simultaneously, regulate negative and positive, cure mainly senile chronic bronchitis, emphysema, pulmonary tuberculosis, bronchial asthma, cough is breathed hard, and dyspnea due to deficiency is spat blood; The empty hyperhidrosis of body, spontaneous perspiration, night sweat; Weak after being ill, prolonged deficiency is not multiple, or the labor that declines is weak, and various chronic debilitating; Deficiency of kidney-QI, soreness of waist and knee joint, impotence and seminal emission; Cancer; Diabetes patient, lupus erythematosus, chronic nephritis and the card such as aplastic anemia and leukopenia.

Fructus Arctii: acrid in the mouth, hardship, cold in nature, enter lung, stomach warp, have wind-dispelling heat-dissipating, lung qi dispersing rash, subduing swelling and detoxicating, the effect of sore-throat relieving, be mainly used in anemopyretic cold and epidemic febrile disease from the beginning of; The headache that wind-fire or expectorant heat are attacked, the pharyngalgia of wind-heat invading the lung, impairment of dispersing and descending function of the lung, sore throat, cough with asthma, edema; The arthralgia of damp-heat arthralgia resistance; The measles without adequate eruption that the strongly fragrant pen of wind heat is caused, macule pathogenic heat stops up stagnant all cards; The cards such as the furuncle swelling toxin of burning hot poison knot.

Bulbus Fritillariae Cirrhosae: bitter in the mouth, sweet, cold nature, enters lung, heart channel, has clearing heat and moistening lung, the effect of preventing phlegm from forming and stopping coughing, for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood, the card such as cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, sore throat, acute mastitis.

Caulis Spatholobi: latin name spatholobicaulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, there is obvious inhibitory action to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.

Concretio silicea Bambusae seu schizostachyi: for meat seat bacterium Concretio silicea Bambusae seu schizostachyi belongs to Stroma and the spore of Fungus Zhuhuang, lightly seasoned, property is put down, and have preventing phlegm from forming and stopping coughing, promoting blood circulation to remove blood stasis, effect of expelling wind and removing dampness, cures mainly cough with copious phlegm, pertussis, leukorrhagia, stomachache, rheumatic arthralgia, infantile convulsion, the cards such as traumatic injury.

Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature, enter lung meridian, Liver Channel, kidney channel, there is the effect of heat-clearing and toxic substances removing, dissipating blood stasis hemostasis, inducing diuresis to remove edema, cure mainly: pyretic toxicity carbuncle; Have sore throat; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Traumatic injury; Spit blood; Epistaxis; Stranguria with blood; Edema; Ascites and cancer.

Radix Ginseng: sweet in the mouth, micro-hardship, slightly warm in nature, enter the heart, lung, spleen channel, have strongly invigorating primordial QI, using tonifying Qi reinforcing lungs, promoting the production of body fluid to quench thirst, to calm the nerves the effects such as Fructus Alpiniae Oxyphyllae, both for emergency treatment of collapse holds up good dose of danger, also for treating the first key medicine of asthenia internal injury, the card of all insufficiency of vital energy and bloods all can be applied, cure mainly that impairment caused by overstrain is deficient, food told in lack of appetite, asthenia, regurgitation, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, the card such as woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are multiple.

Radix Liriopes: latin name liriopesradix, sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.

Herba Solani Lyrati: latin name SolanumlyratumThunb, bitter in the mouth, property is put down, and have clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, anticancer effect, cures mainly cold, fever, icterohepatitis, cholecystitis, cholelithiasis, cancer, uterine erosion, leucorrhea, oedema due to nephritis; External is controlled carbuncle furuncle and phyma poison and is waited card.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enter lung, spleen, kidney channel, have nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, the cards such as early whitening of beard and hair.

Rhizoma Saururi (Herba Saururi): latin name SaururiHerba, sweet in the mouth, pungent, cold in nature, return lung, urinary bladder channel, there is clearing away heat and promoting diuresis; Effect of removing toxic substances and promoting subsidence of swelling, cures mainly pyretic stranguria; Stranguria with blood; Edema; Foot gas; Jaundice; Dysentery; Leukorrhagia; Carbuncle sore tumefacting virus; Eczema; The cards such as venom.

Galla Chinensis: latin name GallaChinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle.

Rhizoma Panacis Majoris: bitter in the mouth, sweet, cold nature, enters liver, lung, stomach warp, have tonifying the lung yin nourishing, dissipating blood stasis stops blooding, the effect of reducing swelling and alleviating pain,, cough due to consumptive disease thirsty for deficiency of both QI and YIN, excessive thirst, various hemorrhage, as haematemesis, hemoptysis, have blood in stool, hematuria, metrorrhagia, traumatic injury wound is swollen, rheumatic arthritis, stomachache, acute toothache, laryngopharynx swelling and pain, the cards such as sore and toxic.

In described medicine, the weight of each crude drug is specially Rhizoma Acori Graminei 15g ~ 25g, Radix Angelicae Dahuricae 35g ~ 45g, Cortex Phellodendri 20g ~ 30g, Herba Asari 15g ~ 25g, Herba Centipedae 20g ~ 30g, Folium Viticis Negundo 15g ~ 25g, Cordyceps 25g ~ 35g, Fructus Arctii 15g ~ 25g, Bulbus Fritillariae Cirrhosae 10g ~ 20g, Caulis Spatholobi 20g ~ 30g, Concretio silicea Bambusae seu schizostachyi 10g ~ 20g, Herba Scutellariae Barbatae 10g ~ 20g, Radix Ginseng 35g ~ 45g, Radix Liriopes 25g ~ 35g, Herba Solani Lyrati 5g ~ 15g, Rhizoma Polygonati 20g ~ 30g, Rhizoma Saururi (Herba Saururi) 15g ~ 25g, Galla Chinensis 20g ~ 30g and Rhizoma Panacis Majoris 15g ~ 25g.

Further preferably, in described medicine, the weight of each crude drug is specially Rhizoma Acori Graminei 18g ~ 22g, Radix Angelicae Dahuricae 38g ~ 42g, Cortex Phellodendri 23g ~ 27g, Herba Asari 18g ~ 22g, Herba Centipedae 23g ~ 27g, Folium Viticis Negundo 18g ~ 22g, Cordyceps 28g ~ 32g, Fructus Arctii 18g ~ 22g, Bulbus Fritillariae Cirrhosae 13g ~ 17g, Caulis Spatholobi 23g ~ 27g, Concretio silicea Bambusae seu schizostachyi 13g ~ 17g, Herba Scutellariae Barbatae 13g ~ 17g, Radix Ginseng 38g ~ 42g, Radix Liriopes 28g ~ 32g, Herba Solani Lyrati 8g ~ 12g, Rhizoma Polygonati 23g ~ 27g, Rhizoma Saururi (Herba Saururi) 18g ~ 22g, Galla Chinensis 23g ~ 27g and Rhizoma Panacis Majoris 18g ~ 22g.

Most preferably, in described medicine, the g of each crude drug is specially Rhizoma Acori Graminei 20g, Radix Angelicae Dahuricae 40g, Cortex Phellodendri 25g, Herba Asari 20g, Herba Centipedae 25g, Folium Viticis Negundo 20g, Cordyceps 30g, Fructus Arctii 20g, Bulbus Fritillariae Cirrhosae 15g, Caulis Spatholobi 25g, Concretio silicea Bambusae seu schizostachyi 15g, Herba Scutellariae Barbatae 15g, Radix Ginseng 40g, Radix Liriopes 30g, Herba Solani Lyrati 10g, Rhizoma Polygonati 25g, Rhizoma Saururi (Herba Saururi) 20g, Galla Chinensis 25g and Rhizoma Panacis Majoris 20g.

Wherein, medicine provided by the invention is injection, and injection adopts hypodermic mode.

Present invention also offers the preparation method of above-mentioned injection, it comprises:

The first step, each crude drug is cleaned respectively, pulverize, mix, by the alcoholic solution heating and refluxing extraction 2 times that determining alcohol is 70% ~ 80%, the time of each extraction is 1 ~ 2 hour, the weight ratio of the Chinese crude drug that alcoholic solution and this step mix is 5 ~ 8: 1, collect extracting solution, filter, concentrating filtrate to 60 DEG C of relative densities is the concentrated solution of 1.02 ~ 1.06, upper macroporous adsorptive resins, the weight of macroporous adsorbent resin is 1 ~ 3 times of the weight of the Chinese crude drug that this step mixes, with the alcoholic solution eluting that determining alcohol is 50% ~ 80%, the volume of described eluent is 5 ~ 20 times of macroporous adsorptive resins volume, collect eluent, concentrated except desolventizing, pulverize, obtain powder,

Second step, gets powder 10g ~ 20g that the first step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 injection 1

By Rhizoma Acori Graminei 20g, Radix Angelicae Dahuricae 40g, Cortex Phellodendri 25g, Herba Asari 20g, Herba Centipedae 25g, Folium Viticis Negundo 20g, Cordyceps 30g, Fructus Arctii 20g, Bulbus Fritillariae Cirrhosae 15g, Caulis Spatholobi 25g, Concretio silicea Bambusae seu schizostachyi 15g, Herba Scutellariae Barbatae 15g, Radix Ginseng 40g, Radix Liriopes 30g, Herba Solani Lyrati 10g, Rhizoma Polygonati 25g, Rhizoma Saururi (Herba Saururi) 20g, Galla Chinensis 25g and Rhizoma Panacis Majoris 20g cleans respectively, pulverize, mix, be the alcoholic solution heating and refluxing extraction 2 times of 80% with 2.5kg determining alcohol, each time of extracting is 2 hours, collect extracting solution, filter, concentrating filtrate to 60 DEG C of relative densities is the concentrated solution of 1.02, upper macroporous adsorptive resins, the weight of macroporous adsorbent resin is 900g, with the alcoholic solution eluting that determining alcohol is 70%, the volume of described eluent is 10 times of macroporous adsorptive resins volume, collects eluent, concentrated except desolventizing, pulverize, obtain powder, get the powder 15g of acquisition, add propylene glycol 30g, add 200ml water for injection, stir and make it dissolve, inject water to 1000ml further, add 1g needle-use activated carbon again, fully stir 50 minutes, decarbonization filtering, with 0.22 μm of filtering with microporous membrane, subpackage embedding.

Embodiment 2 injection 2

By Rhizoma Acori Graminei 18g, Radix Angelicae Dahuricae 38g, Cortex Phellodendri 23g, Herba Asari 18g, Herba Centipedae 23g, Folium Viticis Negundo 18g, Cordyceps 28g, Fructus Arctii 18g, Bulbus Fritillariae Cirrhosae 13g, Caulis Spatholobi 23g, Concretio silicea Bambusae seu schizostachyi 13g, Herba Scutellariae Barbatae 13g, Radix Ginseng 38g, Radix Liriopes 28g, Herba Solani Lyrati 8g, Rhizoma Polygonati 23g, Rhizoma Saururi (Herba Saururi) 18g, Galla Chinensis 23g and Rhizoma Panacis Majoris 18g cleans respectively, pulverize, mix, be the alcoholic solution heating and refluxing extraction 2 times of 80% with 2kg determining alcohol, each time of extracting is 2 hours, collect extracting solution, filter, concentrating filtrate to 60 DEG C of relative densities is the concentrated solution of 1.02, upper macroporous adsorptive resins, the weight of macroporous adsorbent resin is 800g, with the alcoholic solution eluting that determining alcohol is 70%, the volume of described eluent is 10 times of macroporous adsorptive resins volume, collects eluent, concentrated except desolventizing, pulverize, obtain powder, get the powder 15g of acquisition, add propylene glycol 30g, add 200ml water for injection, stir and make it dissolve, inject water to 1000ml further, add 1g needle-use activated carbon again, fully stir 50 minutes, decarbonization filtering, with 0.22 μm of filtering with microporous membrane, subpackage embedding.

Embodiment 3 injection 3

By Rhizoma Acori Graminei 22g, Radix Angelicae Dahuricae 42g, Cortex Phellodendri 27g, Herba Asari 22g, Herba Centipedae 27g, Folium Viticis Negundo 22g, Cordyceps 32g, Fructus Arctii 22g, Bulbus Fritillariae Cirrhosae 17g, Caulis Spatholobi 27g, Concretio silicea Bambusae seu schizostachyi 17g, Herba Scutellariae Barbatae 17g, Radix Ginseng 42g, Radix Liriopes 32g, Herba Solani Lyrati 12g, Rhizoma Polygonati 27g, Rhizoma Saururi (Herba Saururi) 22g, Galla Chinensis 27g and Rhizoma Panacis Majoris 22g cleans respectively, pulverize, mix, be the alcoholic solution heating and refluxing extraction 2 times of 80% with 3kg determining alcohol, each time of extracting is 2 hours, collect extracting solution, filter, concentrating filtrate to 60 DEG C of relative densities is the concentrated solution of 1.02, upper macroporous adsorptive resins, the weight of macroporous adsorbent resin is 1kg, with the alcoholic solution eluting that determining alcohol is 70%, the volume of described eluent is 10 times of macroporous adsorptive resins volume, collects eluent, concentrated except desolventizing, pulverize, obtain powder, get the powder 15g of acquisition, add propylene glycol 30g, add 200ml water for injection, stir and make it dissolve, inject water to 1000ml further, add 1g needle-use activated carbon again, fully stir 50 minutes, decarbonization filtering, with 0.22 μm of filtering with microporous membrane, subpackage embedding.

Embodiment 4 safety detects

Local excitation is tested

With the clinical maximum consumption per day 160mg of 50kg adult, can obtain 2.5kg rabbit dosage by meeh-rubner formula scales is 8.276mg/kg, amplify dosage and namely press clinical administration Cmax 0.32mg/ml, injection 30ml/kg prepared by intravenous drip embodiment 1, the instillation time is 2 hours, every day 1 time, continuous 7 days.Rabbit auricular vein every day instillation concentration is the injection 30ml/kg of 0.32mg/ml, another side gives isopyknic 0.9% sodium chloride injection, the instillation time is 2 hours, every day 1 time, continuous 7 days, observe injection site blood vessel after last administration 24h and have no obviously congested and edema, vessel boundary is clear, and pathologic diagnosis has no the pathological change such as tissue degeneratiaon and necrosis.

Sensitivity test

With the clinical maximum consumption per day 160mg of 50kg adult.Can obtain 350g Cavia porcellus dosage by meeh-rubner formula scales is 15.47mg/kg, and namely 350g Cavia porcellus dosage is 5.413mg/.But because this medicine clinical administration Cmax is 0.32mg/ml, and digital veins of the foot administration finite volume, therefore only inject for digital veins of the foot with 0.32mg/ml concentration, 2ml/ and excite high dose.Cavia porcellus is after the injection 1 of the injection embodiment of the present invention 1 preparation, and animal has no systemic anaphylaxis such as grabbing nose, cough, amyostasia and perpendicular hair.

Pharmacological toxicology is tested, and without anaphylaxis, zest, can ensure the safety of clinical application, illustrate that injection of the present invention is clinical feasible.

Embodiment 5 clinical data

1, physical data

Tell dyspneic IV phase patients with lung cancer 120 example, man 63 example, female 57 example.At 38 ~ 77 years old age, 60 ± 5 years old mean age, be divided into treatment group and matched group, often organize 60 examples.Previously non-life-time service morphine, after treatments such as giving infection, oxygen uptake after being admitted to hospital, eliminate the phlegm, expansion bronchus and suiting the medicine to the illness is supported, dyspnea is without obvious alleviation.There is not respiration inhibition symptom, respiratory frequency > 10 min ^-1.

Therapeutic Method

Matched group: after assessing patient respiratory difficulty, gives morphine 5mg subcutaneous injection, and use the subcutaneous indwelling of venous detaining needle, so that the subcutaneous injection of every 4 ~ 6h, after medication, 60min assesses dyspnea situation again;

Treatment group: give injection 1 subcutaneous injection 10ml prepared by embodiment 1 on the basis of the injection of morphia of matched group, the injection volume of morphine is so that the subcutaneous injection of every 4 ~ 6h, and after medication, 60min assesses dyspnea situation again simultaneously.

Observation index

Subjective index: adopt visual analogue scales (visualanalogscale, VAS:0 ~ 100mm) and Brog scale (0 ~ 10 point), patient respiratory degree of difficulty is assessed.

Objective indicator: respiratory frequency (R), blood oxygen saturation (SaO ₂), heart rate (HR), blood pressure (BP).

Statistical method

Adopt paired comparison t inspection, the significance of each observation index difference of comparison therapy Patients Before And After.

Result

Subjective index result, in table 1.

Table 1 subjective index result

As can be seen from Table 1, injection provided by the invention is adopted to coordinate morphine better can reduce VAS assessed value and Brog appraisal result.

Objective indicator result, in table 2 and table 3.

Table 2 objective indicator result

Table 3 objective indicator result

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (7)

1. be used for the treatment of pulmonary carcinoma and merge a dyspneic medicine, it is characterized in that: crude drug comprises Rhizoma Acori Graminei, the Radix Angelicae Dahuricae, Cortex Phellodendri, Herba Asari, Herba Centipedae, Folium Viticis Negundo, Cordyceps, Fructus Arctii, Bulbus Fritillariae Cirrhosae, Caulis Spatholobi, Concretio silicea Bambusae seu schizostachyi, Herba Scutellariae Barbatae, Radix Ginseng, Radix Liriopes, Herba Solani Lyrati, Rhizoma Polygonati, Rhizoma Saururi (Herba Saururi), Galla Chinensis and Rhizoma Panacis Majoris.

2. be used for the treatment of pulmonary carcinoma as claimed in claim 1 and merge dyspneic medicine, it is characterized in that: the weight of each crude drug is specially Rhizoma Acori Graminei 15g ~ 25g, Radix Angelicae Dahuricae 35g ~ 45g, Cortex Phellodendri 20g ~ 30g, Herba Asari 15g ~ 25g, Herba Centipedae 20g ~ 30g, Folium Viticis Negundo 15g ~ 25g, Cordyceps 25g ~ 35g, Fructus Arctii 15g ~ 25g, Bulbus Fritillariae Cirrhosae 10g ~ 20g, Caulis Spatholobi 20g ~ 30g, Concretio silicea Bambusae seu schizostachyi 10g ~ 20g, Herba Scutellariae Barbatae 10g ~ 20g, Radix Ginseng 35g ~ 45g, Radix Liriopes 25g ~ 35g, Herba Solani Lyrati 5g ~ 15g, Rhizoma Polygonati 20g ~ 30g, Rhizoma Saururi (Herba Saururi) 15g ~ 25g, Galla Chinensis 20g ~ 30g and Rhizoma Panacis Majoris 15g ~ 25g.

3. be used for the treatment of pulmonary carcinoma as claimed in claim 1 or 2 and merge dyspneic medicine, it is characterized in that: the weight of each crude drug is specially Rhizoma Acori Graminei 18g ~ 22g, Radix Angelicae Dahuricae 38g ~ 42g, Cortex Phellodendri 23g ~ 27g, Herba Asari 18g ~ 22g, Herba Centipedae 23g ~ 27g, Folium Viticis Negundo 18g ~ 22g, Cordyceps 28g ~ 32g, Fructus Arctii 18g ~ 22g, Bulbus Fritillariae Cirrhosae 13g ~ 17g, Caulis Spatholobi 23g ~ 27g, Concretio silicea Bambusae seu schizostachyi 13g ~ 17g, Herba Scutellariae Barbatae 13g ~ 17g, Radix Ginseng 38g ~ 42g, Radix Liriopes 28g ~ 32g, Herba Solani Lyrati 8g ~ 12g, Rhizoma Polygonati 23g ~ 27g, Rhizoma Saururi (Herba Saururi) 18g ~ 22g, Galla Chinensis 23g ~ 27g and Rhizoma Panacis Majoris 18g ~ 22g.

4. the pulmonary carcinoma that is used for the treatment of as described in claims 1 to 3 merges dyspneic medicine, it is characterized in that: the g of each crude drug is specially Rhizoma Acori Graminei 20g, Radix Angelicae Dahuricae 40g, Cortex Phellodendri 25g, Herba Asari 20g, Herba Centipedae 25g, Folium Viticis Negundo 20g, Cordyceps 30g, Fructus Arctii 20g, Bulbus Fritillariae Cirrhosae 15g, Caulis Spatholobi 25g, Concretio silicea Bambusae seu schizostachyi 15g, Herba Scutellariae Barbatae 15g, Radix Ginseng 40g, Radix Liriopes 30g, Herba Solani Lyrati 10g, Rhizoma Polygonati 25g, Rhizoma Saururi (Herba Saururi) 20g, Galla Chinensis 25g and Rhizoma Panacis Majoris 20g.

5. the pulmonary carcinoma that is used for the treatment of as described in Claims 1-4 merges dyspneic medicine, it is characterized in that: described medicine is injection.

6. the preparation method of medicine described in claim 1 to 5, is characterized in that, comprising:

The first step, each crude drug is cleaned respectively, pulverize, mix, by the alcoholic solution heating and refluxing extraction 2 times that determining alcohol is 70% ~ 80%, the time of each extraction is 1 ~ 2 hour, the weight ratio of the Chinese crude drug that alcoholic solution and this step mix is 5 ~ 8: 1, collect extracting solution, filter, concentrating filtrate to 60 DEG C of relative densities is the concentrated solution of 1.02 ~ 1.06, upper macroporous adsorptive resins, the weight of macroporous adsorbent resin is 1 ~ 3 times of the weight of the Chinese crude drug that this step mixes, with the alcoholic solution eluting that determining alcohol is 50% ~ 80%, the volume of described eluent is 5 ~ 20 times of macroporous adsorptive resins volume, collect eluent, concentrated except desolventizing, pulverize, obtain powder,

Second step, gets powder 10g ~ 20g that the first step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding.

7. be used for the treatment of pulmonary carcinoma and merge a dyspneic medicine compound, it is characterized in that: comprise the medicine described in Claims 1-4 and morphine.