CN105232331A - Medicine mixer, hard double connectors and infusion soft bag - Google Patents
Medicine mixer, hard double connectors and infusion soft bag Download PDFInfo
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- CN105232331A CN105232331A CN201510781507.XA CN201510781507A CN105232331A CN 105232331 A CN105232331 A CN 105232331A CN 201510781507 A CN201510781507 A CN 201510781507A CN 105232331 A CN105232331 A CN 105232331A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1406—Septums, pierceable membranes
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Hematology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to a medicine mixer. The medicine mixer comprises a base, a medicine mixing channel, a medicine mixing cup and a cross needle, wherein the base, the medicine mixing channel and the medicine mixing cup are integrally formed; the medicine mixing cup comprises cup walls and a cup bottom; the cross needle comprises a needle plate, an upper needle and a lower needle, which are integrally formed; the upper and lower needles are provided with hollow channels communicated with each other. The medicine mixer is characterized in that the lower end of the medicine mixing channel passes through the base and the upper end passes through the cup bottom; a diaphragm is arranged in the medicine mixing channel between the base and the cup bottom; a sealing rubber plug is arranged in the medicine mixing channel between the diaphragm and the cup bottom; limiting bulges are arranged at the inner sides of the cup walls; after the cross needle is installed in the medicine mixing cup, the needle plate is limited between the limiting bulges and the cup bottom by the limiting bulges and can not be taken out; the distance between the upper surface of the cup bottom and the lower surface of the diaphragm is smaller than the length of the lower needle. The invention also provides hard double connectors and an infusion soft bag based on the medicine mixer.
Description
Technical field
The present invention relates to a kind of medicine mixer, particularly a kind of medicine mixer with mixed medicine glass.
Background technology
When using the injectable powder of cillin bottle splendid attire, lyophilized injectable powder or aqueous injection, needing by syringe the liquid medicine in transfusion flexible bag or water for injection to be extracted out to inject in cillin bottle, repeating above-mentioned work, until there are enough medicinal liquids in cillin bottle; And then cillin bottle shaken repeatedly until medicament mix homogeneously in bottle, then with syringe cillin bottle inner liquid medicine extracted out and inject transfusion flexible bag, so repeatedly, until the medicinal liquid in bottle is exhausted.
First, above-mentioned mixed medicine operating process is more time-consuming, effort, take consumptive material as syringe, more seriously, in above-mentioned mixed medicine process, be very easy to the air Injection of outside in cillin bottle and transfusion flexible bag, there is very many various dust, pathogenic bacteria under generic condition in air, enter human body again after being mixed into liquid medicine injection, very serious malpractice can be brought.
Secondly, traditional dosing mode, is first make up a prescription to inject again, is pumped in transfusion flexible bag by the medicine in cillin bottle in advance, then the transfusion flexible bag preparing medicine is brought to ward to patient fluid infusion.After having joined medicine, vacant cillin bottle has been placed, and what medicine what patient protected medical personnel not know to join in transfusion flexible bag completely is, does not possess trackability.Slightly do not note going wrong once medical personnel in dosing, medicinal liquid mismatch is wrong, and consequence is by hardly imaginable.
Again, for the medicine that some are special, such as need the medicine of namely joining namely, traditional dispensing method is very inconvenient, and the various medicine mixer structures disclosed before this patent, not can solve this problem.
Finally, the various medicine mixer structures disclosed before this patent, the problem of Drug leakage after always failing to solve mixed medicine.
For the needs to higher medical service level, in the urgent need to a kind of easy to use, safe, reliable, without the infusion products of potential safety hazard.
Summary of the invention
Based on the problems referred to above, the present invention proposes a kind of easy to use reliable and without the transfusion flexible bag of potential safety hazard and associated medicine mixer, interface.
Medicine mixer proposed by the invention comprises integrated pedestal, mixed medicine passage and mixed medicine glass, cross needle, and described mixed medicine glass is formed by the bottom of wall of cup and cup;
Described cross needle is by integrated needle plate and possess the upper pin of hollow channel and lower pin is formed, and the hollow channel of described upper pin and lower pin communicates with each other;
It is characterized in that:
Described mixed medicine passage lower end is through described pedestal, and upper end, through at the bottom of described cup, is provided with barrier film in the described mixed medicine passage between at the bottom of described pedestal and described cup, is provided with seal rubber plug in the mixed medicine passage between at the bottom of described barrier film and described cup;
The inwall of described wall of cup is provided with restriction protrusion, after described cross needle is installed into described mixed medicine glass, can not be removed between described needle plate is limited at the bottom of described restriction protrusion and described cup by described restriction protrusion;
Upper surface at the bottom of described cup and the distance between described barrier film lower surface are less than the length of described lower pin.
Medicine mixer as above, is characterized in that:
Described restriction protrusion is elastic card claw, the inwall week of wall of cup described in described elastic card claw upper end edge is along being evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass;
Described needle plate at the bottom of described lower end and described cup between.
Medicine mixer as above, is characterized in that:
The thickness of the Distance geometry XiLin bottle cap between at the bottom of described lower end and described cup is basically identical.
As above arbitrary described medicine mixer, is characterized in that:
The upper surface of described plug is a little more than upper surface at the bottom of described cup or substantially concordant with upper surface at the bottom of described cup.
Medicine mixer as above, is characterized in that:
Described plug central area is provided with paracentesis area, and described paracentesis area is thinner than marginal zone;
The central area of described needle plate lower surface is provided with an annular projection, the area coincidence that described paracentesis area and described annular projection limit or be positioned at the region that described annular projection limits.
As above arbitrary described medicine mixer, is characterized in that:
Distance at the bottom of described barrier film upper surface and described cup between upper surface and the consistency of thickness of described plug.
Medicine mixer as above, is characterized in that:
Described barrier film upper surface is provided with bulge loop or groove, and described plug lower surface correspondence position is provided with groove or bulge loop;
Described barrier film is chimeric each other with groove by bulge loop with described plug.
As above arbitrary described medicine mixer, is characterized in that:
The outlet of the hollow channel of described upper pin, is opened on the syringe needle sidewall of described upper pin;
And/or;
The outlet of the hollow channel of described lower pin, is opened on the syringe needle sidewall of described lower pin.
As above arbitrary described medicine mixer, is characterized in that:
Described upper pin is coated with one deck elastic contraction film;
And/or;
Described lower pin is coated with one deck elastic contraction film.
As above arbitrary described medicine mixer, is characterized in that:
Described mixed medicine passage lower end, is provided with foldable handle, and is sealed by the lower end of described foldable handle to described mixed medicine passage.
The medicine mixer of another kind of structure proposed by the invention, comprise integrated pedestal, mixed medicine passage and mixed medicine glass, cross needle, described mixed medicine glass is formed by the bottom of wall of cup and cup;
Described cross needle is by integrated needle plate and possess the upper pin of hollow channel and lower pin is formed, and the hollow channel of described upper pin and lower pin communicates with each other;
It is characterized in that:
Described mixed medicine passage lower end is through described pedestal, and upper end, through at the bottom of described cup, is provided with barrier film in the described mixed medicine passage between at the bottom of described pedestal and described cup, is provided with seal rubber plug in the mixed medicine passage between at the bottom of described barrier film and described cup;
Also comprise elastic clamp seat, described elastic clamp seat comprises a snap ring, elastic card claw is provided with on the downside of described snap ring, snap ring described in described elastic card claw upper end edge is evenly arranged and fixes, described elastic card claw lower end is free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass;
Described needle plate is installed under the described elastic card claw in described mixed medicine glass;
The inwall of described wall of cup is provided with restriction protrusion, and described elastic clamp seat is installed in described mixed medicine glass and is limited by described restriction protrusion;
Upper surface at the bottom of described cup and the distance between described barrier film lower surface are less than the length of described lower pin.
Medicine mixer as above, is characterized in that:
Described elastic clamp seat has integrated base plate, support column, described snap ring and described elastic card claw, and described base plate periphery is provided with support column and supports fixing to described snap ring formation;
Described base plate is provided with centre bore, and described lower pin is formed through described centre bore thus to described crosspointer and locates;
Described needle plate is between described base plate and described elastic card claw.
Medicine mixer as above, is characterized in that:
The thickness of the Distance geometry XiLin bottle cap between described lower end and described base plate is basically identical.
As above arbitrary described medicine mixer, is characterized in that:
Described elastic clamp seat is installed on by after described restriction protrusion restriction in described mixed medicine glass, and described base plate is adjacent at the bottom of described cup.
Medicine mixer as above, is characterized in that:
The central area of described base plate lower surface is provided with an annular projection, and the region that described annular projection limits is completely overlapping with described centre bore, and arranges with described mixed medicine channel coaxial;
Described base plate is adjacent at the bottom of described cup by described annular projection.
Medicine mixer as above, is characterized in that:
The upper surface of described plug is a little more than upper surface at the bottom of described cup or substantially concordant with upper surface at the bottom of described cup;
Described annular projection is adjacent to described plug and/or forms a pressure to described plug.
Medicine mixer as above, is characterized in that:
Described plug central area is provided with paracentesis area, and described paracentesis area is thinner than marginal zone;
The area coincidence that described paracentesis area and described annular projection limit or be positioned at the region that described annular projection limits.
As above arbitrary described medicine mixer, is characterized in that:
Distance at the bottom of described barrier film upper surface and described cup between upper surface and the consistency of thickness of described plug.
Medicine mixer as above, is characterized in that:
Described barrier film upper surface is provided with bulge loop or groove, and described plug lower surface correspondence position is provided with groove or bulge loop;
Described barrier film is chimeric each other with groove by bulge loop with described plug.
As above arbitrary described medicine mixer, is characterized in that:
The outlet of the hollow channel of described upper pin, is opened on the syringe needle sidewall of described upper pin;
And/or;
The outlet of the hollow channel of described lower pin, is opened on the syringe needle sidewall of described lower pin.
As above arbitrary described medicine mixer, is characterized in that:
Described upper pin is coated with one deck elastic contraction film;
And/or;
Described lower pin is coated with one deck elastic contraction film.
As above arbitrary described medicine mixer, is characterized in that:
Described mixed medicine passage lower end, is provided with foldable handle, and is sealed by the lower end of described foldable handle to described mixed medicine passage.
A kind of medicine mixer, comprises integrated pedestal, mixed medicine passage and mixed medicine glass, and cross needle and elastic clamp seat, and described mixed medicine glass is formed by the bottom of wall of cup and cup, it is characterized in that;
Described elastic clamp seat has integrated base plate, support column, snap ring and elastic card claw, and described base plate periphery is provided with described support column and fixes to be formed to support to described snap ring,
Elastic card claw is provided with on the downside of described snap ring, snap ring described in described elastic card claw upper end edge is evenly arranged and fixes, described elastic card claw lower end is free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass;
Described cross needle comprises the upper pin and lower pin that are vertically fixed on described base plate center respectively, and the hollow channel of described upper pin and lower pin passes described base plate center and communicates with each other;
Described elastic clamp seat to be arranged in described mixed medicine glass and when being pushed at the bottom of described cup, being limited and can not take out by described wall of cup;
Described mixed medicine passage lower end is through described pedestal, and upper end, through at the bottom of described cup, is provided with barrier film in the described mixed medicine passage between at the bottom of described pedestal and described cup, is provided with seal rubber plug in the mixed medicine passage between at the bottom of described barrier film and described cup;
Upper surface at the bottom of described cup and the distance between described barrier film lower surface are less than the length of described lower pin.
Medicine mixer as above, is characterized in that:
The thickness of the Distance geometry XiLin bottle cap between described lower end and described base plate is basically identical.
As above arbitrary described medicine mixer, is characterized in that:
Described in the central area ring of described base plate lower surface, lower pin is provided with an annular projection;
Described base plate is adjacent at the bottom of described cup by described annular projection.
Medicine mixer as above, is characterized in that:
The upper surface of described plug is a little more than upper surface at the bottom of described cup or substantially concordant with upper surface at the bottom of described cup;
Described annular projection is adjacent to described plug and/or forms a pressure to described plug.
Medicine mixer as above, is characterized in that:
Described plug central area is provided with paracentesis area, and described paracentesis area is thinner than marginal zone;
The area coincidence that described paracentesis area and described annular projection limit or be positioned at the region that described annular projection limits.
As above arbitrary described medicine mixer, is characterized in that:
Distance at the bottom of described barrier film upper surface and described cup between upper surface and the consistency of thickness of described plug.
Medicine mixer as above, is characterized in that:
Described barrier film upper surface is provided with bulge loop or groove, and described plug lower surface correspondence position is provided with groove or bulge loop;
Described barrier film is chimeric each other with groove by bulge loop with described plug.
As above arbitrary described medicine mixer, is characterized in that:
The outlet of the hollow channel of described upper pin, is opened on the syringe needle sidewall of described upper pin;
And/or;
The outlet of the hollow channel of described lower pin, is opened on the syringe needle sidewall of described lower pin.
As above arbitrary described medicine mixer, is characterized in that:
Described upper pin is coated with one deck elastic contraction film;
And/or;
Described lower pin is coated with one deck elastic contraction film.
As above arbitrary described medicine mixer, is characterized in that:
Described mixed medicine passage lower end, is provided with foldable handle, and is sealed by the lower end of described foldable handle to described mixed medicine passage.
There is the medicine mixer strengthening structure, it is characterized in that: comprise as above arbitrary described medicine mixer;
On the described wall of cup of described mixed medicine glass, be provided with reinforcing rib structure to strengthen the comprcssive strength of described wall of cup.
Medicine mixer as above, is characterized in that:
Described reinforcement to be arranged on inside described wall of cup along the vertical direction and/or horizontal direction one is arranged.
The invention allows for a kind of sealed medicine mixer, comprise as above arbitrary described medicine mixer, it is characterized in that:
The rim of a cup of described mixed medicine glass is sealed.
Medicine mixer as above, is characterized in that:
What seal the rim of a cup of described mixed medicine glass is diaphragm seal.
Medicine mixer as above, is characterized in that:
Described diaphragm seal is easily tore film.
As above arbitrary described medicine mixer, is characterized in that:
Also comprise a cover plate, described cover plate is positioned at described rim of a cup, and is covered by described diaphragm seal.
Medicine mixer as above, is characterized in that:
Described rim of a cup place is provided with step-like interior edge along described wall of cup, and cover plate is shelved on described interior along upper;
Described cover plate upper surface is concordant with described rim of a cup or a little less than described rim of a cup;
Described diaphragm seal hot pressing at described wall of cup upper end face, thus forms sealing to described rim of a cup.
Medicine mixer as above, is characterized in that:
Described cover plate cross section is polygon.
Medicine mixer as above, is characterized in that:
Described cover plate and described cross needle are coaxially arranged;
The needle point of described upper pin is just to described cover plate central.
Medicine mixer as above, is characterized in that:
Described cover plate central is provided with a through hole, and described through hole internal diameter is less than described upper pin external diameter, and the needle point of described upper pin is positioned at described through hole but does not pass described through hole.
The invention allows for a kind of hard double nip with medicine mixer, comprise as above arbitrary described medicine mixer, it is characterized in that:
Relative to the opposite side of described mixed medicine passage on the described pedestal of described medicine mixer, be provided with an infusion channel.
Hard double nip as above, is characterized in that:
Described infusion channel and described pedestal one-body molded;
Described infusion channel and described mixed medicine passage side by side parallel are arranged.
The invention allows for a kind of transfusion flexible bag with hard double nip, it is characterized in that:
Described hard double nip is as above arbitrary described hard double nip.
A kind of transfusion flexible bag with medicine mixer that the present invention proposes, is characterized in that: described medicine mixer is as above arbitrary described medicine mixer;
Described medicine mixer is bonded together by described pedestal and described soft bag.
Transfusion flexible bag as above, is characterized in that:
Also comprise an infusion connector, described infusion connector is arranged on described medicine mixer homonymy, or is arranged on the opposite side relative with described medicine mixer.
Accompanying drawing explanation
Fig. 1 pedestal and mixed medicine glass sectional view
Fig. 2 plug top view
Fig. 3 elastic clamp seat sectional view
Fig. 4 cross needle
The cross needle that Fig. 5 through-hole side is opened
The cross needle axonometric chart that Fig. 6 through-hole side is opened
Fig. 7 is coated with the cross needle of resilientiy stretchable film
Cross needle after the compression of Fig. 8 Collapsible strainer
Fig. 9 installs the medicine mixer after elastic clamp seat and cross needle
Figure 10 cross needle and elastic clamp seat integral structure figure
Figure 11 is provided with the medicine mixer structure chart of integrated elastic deck
The mixed medicine glass sectional view of elastic card claw is established in Figure 12
Figure 13 is provided with the medicine mixer of cross needle
Figure 14 cillin bottle puts into the structure chart after medicine mixer
The medicine mixer of Figure 15 band foldable handle
The transfusion flexible bag of Figure 16 band medicine mixer
Figure 17 strengthens structure and mixes medicine glass
Figure 18 strengthens structure cover plate
Description of reference numerals: 1 transfusion flexible bag, 2 pedestals, 3 mixed medicine glasses, 3-1 wall of cup, at the bottom of 3-2 cup, 3-3 mixes medicine glass reinforcement, 4 elastic clamp seats, 4-1 elastic card claw, 4-2 annular projection, 4-3 centre bore, 4-4 support column, 4-5 base plate, 4-6 snap ring, 5 cross needles, 5-1 needle plate, the upper pin of 5-2, pin under 5-3,5-4 side opening, 5-5 needle point, 6 plugs, 6-1 paracentesis area, 6-2 bulge loop/groove, 6-3 bulge loop/groove, 7 mixed medicine passage, 8 barrier films, 9 cillin bottles, 10 foldable handles, 11 infusion channel, 12 cover plates, 12-1 through hole, 12-2 cover plate reinforcement, 13 diaphragm seals
Specific implementation method
Below, in conjunction with Figure of description, the present invention is further detailed.
First embodiment
As shown in Figure 1, comprise pedestal 2, mixed medicine glass 3, barrier film 8 and mixed medicine passage 7, the above-mentioned medicine mixer body construction be made up of pedestal 2, mixed medicine glass 3, barrier film 8 and mixed medicine passage 7 is formed in integrated mode.
Plug 6 is placed in mixed medicine passage, is positioned on barrier film 8.
Elastic clamp seat 4 is as described in Figure 3 placed in mixed medicine glass, as figure 4 ?the cross needle 5 shown in 8 be placed in elastic clamp seat 4, thus the medicine mixer formed as shown in Figure 9, after elastic clamp seat 4 and cross needle 5 install, there is cover plate 12 at the rim of a cup position of sound production of mixed medicine glass 3, then cover diaphragm seal 13 and mixed medicine glass is sealed.
Be understandable that, infusion channel 11, can be one-body molded together with above-mentioned medicine mixer body construction, also can adopt other infusion connector when soft bag bag.
Mixed medicine passage 7 through pedestal 2 upwards extends straight-through to mix at the bottom of the cup of medicine glass 33 ?2, the effect of barrier film 8 is that isolated medicinal liquid contacts with the direct of plug, accomplish the sealing completely before using, can be arranged in any position of the mixed medicine passage under plug 6 in theory, such as the barrier film 8 shown in Fig. 1,11 is close under plug 6; Or as shown in Fig. 9,12,13, barrier film 8 is positioned at the position under plug.But consider if barrier film 8 position is too low, cause lower pin 5 ?3 of cross needle 5 long, so preferably barrier film 8 to be positioned under plug 6 and to be close to the lower surface of plug 6.
Plug 6 is placed in mixed medicine passage, on barrier film.The effect of plug be ensure lower pin 5 ?3 after puncture plug 6 with barrier film 8, medicinal liquid from barrier film 8 and lower pin 5 ?flow out gap between 3 outer walls after be unlikely to ooze out mixed medicine passage, that is, the external diameter of plug 6 and the internal diameter of mixed medicine passage match, and make plug 6 and mixed medicine passage close contact.
Preferably, at the bottom of plug 6 upper surface and cup 3 ?2 upper surfaces substantially flush with or slightly higher than upper surface, thus, the lower surface of elastic clamp seat 4 as shown in Figure 3, pushes down the upper surface of plug 6.
As a preferred technical scheme, barrier film 8 to be positioned under plug 6 and to be close to the lower surface of plug 6, can better prevent medicinal liquid from after lower needle-penetration barrier film, infiltrating mixed medicine passage.Especially, plug be as described in Figure 2 provided with on the surface by bulge loop or groove 6 ?2,6 ?3 thinner paracentesis areas limited 6 ?1, relative with the bulge loop on plug or groove, the corresponding position of barrier film 8 upper surface is also provided with groove or bulge loop.It is evident that, the bulge loop on plug or groove and the groove on barrier film 8 or bulge loop mutually chimeric, thus reach the object better preventing Drug leakage.
Be provided with plug 6 and the barrier film 8 of mutually chimeric groove or bulge loop, after elastic clamp seat 4 pairs of plugs 6 form a squeezing action, the seepage of medicinal liquid after mixed medicine can being stopped completely.
For elastic clamp seat 4 as shown in Figure 3, comprise a snap ring 4 ?6, be provided with on the downside of described snap ring elastic card claw 4 ?1, described elastic card 4 ?snap ring described in 1 upper end edge to be evenly arranged and fixing, described elastic card claw 4 ?1 lower end be free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass.Described elastic clamp seat have integrated base plate 4 ?5, support column 4 ?4, snap ring 4 ?6 and elastic card claw 4 ?1, described base plate 4 ?5 peripheries be provided with support column 4 ?4 to described snap ring 4 ?6 formed support fixing.
Described base plate 4 ?5 be provided with centre bore 4 ?3, described lower pin 5 ?3 through described centre bore, location is formed to described crosspointer.Around being provided with circle annular projection 4 ?2 around centre bore 4 ?3, after elastic clamp seat 4 is installed in mixed medicine glass, annular projection 4 ?2 on elastic clamp seat 4 can form a squeezing action to plug.
Described wall of cup 3 ?1 inwall on be provided with restriction protrusion (not shown), described elastic clamp seat 4 is installed in described mixed medicine glass and is limited by described restriction protrusion.
As figure 4 ?crosspointer 5 as described in 8, its needle plate 5 ?1 be installed on described elastic card claw in described mixed medicine glass 4 ?under 1, base plate 4 ?on 5.Crosspointer 5 comprise integrated hollow upper pin 5 ?2 and lower pin 5 ?3 and needle plate 5 that upper pin and lower pin are combined as a whole ?1, upper pin 5 ?2, lower pin 5 ?3 heads be provided with needle point 5 ?5.
For crosspointer 5, the outlet of the hollow channel of upper pin 5 ?4, can be opened in described upper pin 5 ?2 syringe needle sidewall on; Same, the outlet of the hollow channel of described lower pin, be opened in described lower pin 5 ?3 syringe needle sidewall on (not shown).Setting like this is that the edge of outlet forms directly cutting to stopper and produces a large amount of chips in order to avoid upper pin, lower pin are when puncturing plug, bottle stopper.By being arranged on the sidewall of syringe needle by outlet, needle point directly thrusts in plug, can not form direct dissection, reduces the generation of chip.
Or, as figure 7 ?shown in 8, upper pin is coated with one deck elastic contraction film, and elastic contraction film is compressed after piercing, is deposited in around puncturing hole, thus can effectively prevent medicinal liquid along puncturing hole gap leakage out.It is evident that, lower pin equally can coated one deck elastic contraction film, to solve seepage to appear in medicinal liquid problem along the gap of puncturing hole.
For the combination of crosspointer 5, elastic clamp seat 4 and mixed medicine glass 3, pedestal 2, as described in Figure 9, mixed medicine glass and pedestal one-body molded, and elastic clamp seat 4 is placed in 3 of mixed medicine glass, and crosspointer 5 is fastened in elastic clamp seat 4.
Specifically, elastic clamp seat 4 is placed in after in mixed medicine glass 3, be arranged at wall of cup 3 ?1 inwall on restriction protrusion (not shown) limit, thus make elastic clamp seat 4 can not skid off mixed medicine glass after placing.In addition, the confined position of elastic clamp seat 4, make the bottom of elastic clamp seat 4 to contact at the bottom of the cup of described mixed medicine glass 33 ?2.In the plan of establishment of preferred plug 6, annular projection bottom elastic clamp seat 44 ?2 can form extruding to plug 6.
Be installed on the crosspointer 5 among elastic clamp seat 4, needle plate 5 ?1 of crosspointer 5 is between elastic card claw 4 ?1 and base plate 4 ?5, and after being provided with, lower pin 5 ?3 does not pierce through plug 6.
Certainly, be also understandable that, before the use, lower pin 5 ?3 parts thrust in plug 6, or as shown in Figure 9 plug 6 to be punctured completely, or more preferably an aperture is preset at plug 6 center, form annular plug, lower pin 5 ?3 by aperture puncture plug 6, are all feasible schemes.When being designed to annular plug, plug central small hole diameter than lower pin 5 ?3 little, make lower pin 5 ?3 insert apertures in plug 6 and through after plug 6, lower pin 5 ?3 pairs of plugs 6 can not form dissection, thus can effectively avoid lower pin 5 ?3 form the pollution that micro-bits cause medicinal liquid when puncturing plug 6.And, due to hole diameter than lower pin 5 ?3 external diameter little, plug 6 still can be close to lower pin 5 ?3 thus avoid leakage.
As for the state used, as shown in Figure 14,15, cillin bottle 9 inserts in mixed medicine glass 3, the bottle cap of cillin bottle 9 is pressed in elastic clamp seat 4, make elastic card claw 4 ?1 free end be positioned at the bottleneck of cillin bottle 9 and be stuck in described bottleneck, thus can not to exit from mixed medicine glass 3 cillin bottle 9 is stuck.
Meanwhile, the bottle cap of cillin bottle 9 by upper pin 5 ?2 to pierce through, bottle cap push downwards needle plate 5 ?1, thus promote lower pin 5 ?3 pierce through plug 6, then pierce through barrier film 8, mixed medicine passage 7 is communicated with cillin bottle by crosspointer 5.
It is evident that, the snap ring of elastic clamp seat 44 ?6 internal diameters and cillin bottle external diameter basically identical, or slightly larger than described cillin bottle external diameter.And in order to better fixedly limit cillin bottle 9, cillin bottle 9 is not slided, the bottle cap thickness of cillin bottle 9 should and the free end of elastic card claw 4 ?1 basically identical to the distance between base plate 4 ?5, make cillin bottle 9 just by bottle cap be stuck in elastic card claw 4 ?1 free end and base plate 4 ?between 5, and can not to move up and down.
Certainly, be understandable that, for the consideration of processing tolerance etc., the distance between the free end of elastic card claw 4 ?1 to base plate 4 ?5 slightly larger than bottle cap thickness, also can not appreciable impact cillin bottle docking and fix.
By above-mentioned setting, can to make up a prescription safely, easily and efficiently, dosing, completely solve the secondary pollution problem in link of making up a prescription.Cillin bottle 9 simultaneously also can ensure that transfusion can be reviewed, because after from the elastic clamp seat 4 that cillin bottle 9 docking is fixed to mixed medicine glass 3, just can not nondestructively take out.That is, from making up a prescription, complete to transfusion, until reclaim link, can trace back to added, which kind of medicine what inject is.
And a class is needed to the medicine of special preservation, for example need namely to join i.e. note type, may also there are some inconveniences in above-mentioned medicine mixer because the medicine of cillin bottle fill must be taken to ward, then cillin bottle is docked with medicine mixer, then making up a prescription in ward uses at once.
Namely joining demand namely to meet medical personnel more easily, on the basis of said structure, having set up foldable handle 10, as shown in figure 15.
Foldable handle 10 is set in mixed medicine passage lower end, as shown in figure 15, cillin bottle 9 and the elastic clamp seat 4 in mixed medicine glass 3 is completed after docking and puncturing, bring to pharmacy, before transfusion, break disconnected foldable handle 10, get through mixed medicine passage, dispensing site can be completed, onsite application.
As shown in Figure 1, medicine mixer be arranged side by side together with the infusion channel 11 in pedestal 2, form hard double nip.
Medicine mixer is connected together by the mode of welding with transfusion flexible bag 1, forms the transfusion flexible bag 1 of band medicine mixer, as shown in figure 16.Described medicine mixer connects 1 by described pedestal 2 with transfusion flexible bag and is combined.
Be understandable that, infusion channel 11 can with medicine mixer setting side by side on the base 2, as shown in Figure 1.Infusion channel also can by another one pedestal independent be welded on transfusion flexible bag 1, be arranged at transfusion flexible bag 1 and medicine mixer homonymy or relative opposite side, or other positions of transfusion flexible bag 1 for a person skilled in the art, are all apparent settings.
About shape and the structure of pedestal, after medicine mixer, infusion channel or band medicine mixer and the hard double nip of infusion channel are welded on soft bag, in storage, transport and use procedure, the damage that pedestal welding position causes transfusion flexible bag, foundation design is dumb-bell shape or ship shape, as shown in the pedestal 2 in Fig. 1, and the lower end of mixed medicine passage 7, infusion channel 11 is concordant with the lower end of pedestal 2.Uniform welding lines on the surrounding sidewall of pedestal 2, can well ensure to be in the welding process of transfusion flexible bag like this, even pedestal 2 also well can fuse welding with soft bag 2 at a lower temperature.And, the pedestal of ship shape or dumb-bell shape, streamlined good, improve the mechanical property of welding not to the utmost, and there is no sharp angle, the combination of hard double nip and transfusion flexible bag 2 can be made more level and smooth, not fragile soft bag.
Finally, in order to ensure transfusion flexible bag safety asepsis in use, need to seal mixed medicine glass.Sealed mixed medicine cup generally adopts easily tore film, than even more preferably pp easily tore film, preferably with the pp easily tore film of certain air permeability.Easily tore film is directly pressed together on mixed medicine glass rim of a cup place, during use, directly tears easily tore film.
Because after transfusion flexible bag 1 fill, seal, then carry out high temperature sterilize.If do not sealed mixed medicine glass, the transfusion flexible bag with medicine mixer after sterilizing, due in mixed medicine glass with puncture cross needle 5 be still exposed in external environment condition, transport use time must evitable meeting contaminated, still can not ensure its aseptic.
And the mixed medicine glass after sealing, when sterilizing, owing to being under high temperature and high pressure environment, the cup of the mixed medicine glass be made up of medical polymer material, and the easily tore film material of sealed mixed medicine cup, can shrink in deliquescing; It is inside and outside that mixed medicine glass is closed, and there is a larger pressure differential, under the effect of high pressure, mixed medicine glass and easily tore film all can be out of shape, medicine glass can be mixed after cooling and easily tore film is damaged by pressure completely, thus destroy medicine mixer structure, cause medicine mixer can not use completely.
In order to solve the problem, be the wall of cup to mixed medicine glass than more preferably way, preferential is in wall of cup Lower Half, arranges reinforcement 3 ?3, as shown in figure 17.
Reinforcement can be arranged on inside wall of cup and/or the vertical bar integrated with mixed medicine glass of equally distributed projection in outside, or horizontal stripe, or crisscross network structure.Preferably along the equally distributed perpendicular list structure of Lower Half inside wall of cup; At the bottom of more preferably the vertical bar of projection to extend to glass from Lower Half inside wall of cup, most preferably the thickness of vertical bar projection is level and smooth gradually from top to bottom increases continuously.
Wall of cup is arranged reinforcement 3 ?3 substantially can solve mixed medicine glass in sterilization process and be not crushed out of shape, but the diaphragm seal that also there is sealed mixed medicine cup when sterilizing by the problem of compression.
In order to address this problem, be also provided with a cover plate 12 as shown in figure 18 at mixed medicine glass rim of a cup place, diaphragm seal 13 covers cover plate 12, makes cover plate form effective support to diaphragm seal, prevents diaphragm seal when sterilizing by compression.Step-like interior edge is provided with along described wall of cup at rim of a cup place, cover plate is shelved on described step-like interior along upper, make the upper surface of the cover plate being arranged on rim of a cup place concordant with rim of a cup or a little less than described rim of a cup, can not impact the sealing technology of diaphragm seal hot pressing at described wall of cup upper end face.
For the shape of cover plate 12, can be rounded, consistent with mixed medicine glass rim of a cup, but preferred cover plate shape is cross section is polygon, such as pentagon, hexagon, octagon, 12 distortion.
For the setting of cover plate 12, preferred cover plate and cross needle are coaxially arranged, the needle point of upper pin 5 ?5 just to cover plate central.
More have preferably, cover plate central be provided with a through hole 12 ?1, through hole internal diameter be less than pin 5 ?2 external diameter, upper pin 5 ?2 needle point 5 ?5 parts be positioned at through hole but can not described through hole be passed, thus make pin 5 ?2 pairs of cover plates also have a supporting role.
And the cover plate shape of decision design---polygon and the structure of middle with hole, experiment shows, after have employed air pressure balance means, this decision design, the air pressure inside and outside mixed medicine glass can be allowed faster to reach balance, thus in wet heating sterilization process, showing more outstanding---diaphragm seal is as before smooth, and mixed medicine glass is not at all out of shape.This is because polygon and the cover plate of middle with hole, can add under large cover and the atmosphere exchange rate in region on cover plate, can allow air pressure equalisation in mixed medicine glass faster, allow mixed medicine glass other balances inside and outside.
Second embodiment
On the basis of above-described embodiment 1, for the set-up mode of the elastic clamp seat 4 in the first embodiment, as shown in figure 12 in example 2, adopt the restriction protrusion 4 be directly fixed on mixed medicine glass inwall to replace the elastic clamp seat 4 in embodiment 1.Restriction protrusion 4 preferably elastic card claw; More preferably, as the elastic card claw of restriction protrusion 4 and described mixed medicine glass 3 one-body molded.Inwall week of wall of cup described in elastic card claw upper end edge, described elastic card claw lower end was free end along to be evenly arranged and fixing, and described elastic card claw 4 from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass, as shown in figure 12.
After the mixed medicine glass using the installation of the cross needle as shown in figure 4 ?8 forward (FWD) restriction protrusion 4, as shown in figure 13, can not be removed between needle plate 5 ?1 of cross needle 5 is limited at the bottom of restriction protrusion and cup by restriction protrusion 4.Shown in Figure 13 is that cross needle 5 has pierced through plug 6 and not yet pierced through the state of barrier film 8.
It is evident that, upper surface at the bottom of cup and the distance between barrier film lower surface are less than the length of described lower pin.
For other structures of medicine mixer, there is the setting the same with embodiment 1.
3rd embodiment
On the basis of above-described embodiment 1, for the set-up mode of the elastic clamp seat 4 in the first embodiment, as shown in Figure 10 in embodiment 3, crosspointer 5 and described elastic clamp seat 4 are directly fixed, preferably crosspointer 5 is one-body molded with elastic clamp seat.
The same with the elastic clamp seat in embodiment 1, elastic clamp seat comprise a snap ring 4 ?6, be provided with on the downside of described snap ring elastic card claw 4 ?1, described elastic card claw 4 ?snap ring described in 1 upper end edge to be evenly arranged and fixing, described elastic card claw 4 ?1 lower end be free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass.Described elastic clamp seat have integrated base plate 4 ?5, support column 4 ?4, snap ring 4 ?6 and elastic card claw 4 ?1, described base plate 4 ?5 peripheries be provided with support column 4 ?4 to described snap ring 4 ?6 formed support fixing.
Difference be eliminate described base plate 4 ?centre bore on 54 ?3, crosspointer 5 is integrated to be directly fixed on base plate.Upper pin 5 ?2 with lower pin 5 ?3 structure still as figure 4 ? the structure shown in 8, upper pin 5 ?2 and lower pin 5 ?3 hollow channel through elastic clamp seat 4 base plate 4 ?5 center and communicate with each other.
At the root of lower pin 5 ?3, be provided with circle annular projection 4 ?2, after elastic clamp seat 4 is installed in mixed medicine glass, annular projection 4 ?2 on elastic clamp seat 4 can form a squeezing action to plug.
Before use, described elastic clamp seat 4 to be arranged in described mixed medicine glass 4 and when being pushed at the bottom of described cup, being limited and can not take out by described wall of cup.As shown in figure 11, time at the bottom of the elastic clamp seat 4 of band cross needle 5 is pushed to glass, under all form puncture for plug 6 and barrier film 8.Certainly,
For other structures of medicine mixer, there is the setting the same with embodiment 1.
It should be noted that: the only unrestricted technical scheme of the present invention in order to explanation above, although with reference to above-described embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: still can modify to the present invention or equivalent replacement, and do not depart from any modification or partial replacement of the spirit and scope of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (10)
1. a medicine mixer, comprise integrated pedestal, mixed medicine passage and mixed medicine glass, cross needle, described mixed medicine glass is formed by the bottom of wall of cup and cup;
Described cross needle is by integrated needle plate and possess the upper pin of hollow channel and lower pin is formed, and the hollow channel of described upper pin and lower pin communicates with each other;
It is characterized in that:
Described mixed medicine passage lower end is through described pedestal, and upper end, through at the bottom of described cup, is provided with barrier film in the described mixed medicine passage between at the bottom of described pedestal and described cup, is provided with seal rubber plug in the mixed medicine passage between at the bottom of described barrier film and described cup;
The inwall of described wall of cup is provided with restriction protrusion, after described cross needle is installed into described mixed medicine glass, can not be removed between described needle plate is limited at the bottom of described restriction protrusion and described cup by described restriction protrusion;
Upper surface at the bottom of described cup and the distance between described barrier film lower surface are less than the length of described lower pin.
2. medicine mixer as claimed in claim 1, is characterized in that:
Described restriction protrusion is elastic card claw, the inwall week of wall of cup described in described elastic card claw upper end edge is along being evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass;
Described needle plate at the bottom of described lower end and described cup between.
3. a medicine mixer, comprise integrated pedestal, mixed medicine passage and mixed medicine glass, cross needle, described mixed medicine glass is formed by the bottom of wall of cup and cup;
Described cross needle is by integrated needle plate and possess the upper pin of hollow channel and lower pin is formed, and the hollow channel of described upper pin and lower pin communicates with each other;
It is characterized in that:
Described mixed medicine passage lower end is through described pedestal, and upper end, through at the bottom of described cup, is provided with barrier film in the described mixed medicine passage between at the bottom of described pedestal and described cup, is provided with seal rubber plug in the mixed medicine passage between at the bottom of described barrier film and described cup;
Also comprise elastic clamp seat, described elastic clamp seat comprises a snap ring, elastic card claw is provided with on the downside of described snap ring, snap ring described in described elastic card claw upper end edge is evenly arranged and fixes, described elastic card claw lower end is free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass;
Described needle plate is installed under the described elastic card claw in described mixed medicine glass;
The inwall of described wall of cup is provided with restriction protrusion, and described elastic clamp seat is installed in described mixed medicine glass and is limited by described restriction protrusion;
Upper surface at the bottom of described cup and the distance between described barrier film lower surface are less than the length of described lower pin.
4. medicine mixer as claimed in claim 3, is characterized in that:
Described elastic clamp seat has integrated base plate, support column, described snap ring and described elastic card claw, and described base plate periphery is provided with support column and supports fixing to described snap ring formation;
Described base plate is provided with centre bore, and described lower pin is formed through described centre bore thus to described crosspointer and locates;
Described needle plate is between described base plate and described elastic card claw.
5. a medicine mixer, comprises integrated pedestal, mixed medicine passage and mixed medicine glass, and cross needle and elastic clamp seat, and described mixed medicine glass is formed by the bottom of wall of cup and cup, it is characterized in that;
Described elastic clamp seat has integrated base plate, support column, snap ring and elastic card claw, and described base plate periphery is provided with described support column and fixes to be formed to support to described snap ring,
Elastic card claw is provided with on the downside of described snap ring, snap ring described in described elastic card claw upper end edge is evenly arranged and fixes, described elastic card claw lower end is free end, and described elastic card claw from fixing described upper end to described lower end freely in the centroclinal structure of described mixed medicine glass;
Described cross needle comprises the upper pin and lower pin that are vertically fixed on described base plate center respectively, and the hollow channel of described upper pin and lower pin passes described base plate center and communicates with each other;
Described elastic clamp seat to be arranged in described mixed medicine glass and when being pushed at the bottom of described cup, being limited and can not take out by described wall of cup;
Described mixed medicine passage lower end is through described pedestal, and upper end, through at the bottom of described cup, is provided with barrier film in the described mixed medicine passage between at the bottom of described pedestal and described cup, is provided with seal rubber plug in the mixed medicine passage between at the bottom of described barrier film and described cup;
Upper surface at the bottom of described cup and the distance between described barrier film lower surface are less than the length of described lower pin.
6. have and strengthen the medicine mixer of structure, it is characterized in that: comprise as arbitrary in claim 1 ?5 as described in medicine mixer;
On the described wall of cup of described mixed medicine glass, be provided with reinforcing rib structure to strengthen the comprcssive strength of described wall of cup;
Described reinforcement to be arranged on inside described wall of cup along the vertical direction and/or horizontal direction one is arranged.
7. a sealed medicine mixer, comprise as arbitrary in claim 1 ?6 as described in medicine mixer, it is characterized in that:
The rim of a cup of described mixed medicine glass is sealed by diaphragm seal;
Described diaphragm seal is easily tore film.
8. medicine mixer as claimed in claim 7, is characterized in that:
Also comprise a cover plate, described cover plate is positioned at described rim of a cup, and is covered by described diaphragm seal;
Described rim of a cup place is provided with step-like interior edge along described wall of cup, and cover plate is shelved on described interior along upper;
Described cover plate upper surface is concordant with described rim of a cup or a little less than described rim of a cup;
Described diaphragm seal hot pressing at described wall of cup upper end face, thus forms sealing to described rim of a cup.
9. the hard double nip with medicine mixer, comprise as arbitrary in claim 1 ?8 as described in medicine mixer, it is characterized in that:
Relative to the opposite side of described mixed medicine passage on the described pedestal of described medicine mixer, be provided with an infusion channel;
Described infusion channel and described pedestal one-body molded;
Described infusion channel and described mixed medicine passage side by side parallel are arranged.
10. a transfusion flexible bag, is characterized in that: described transfusion flexible bag comprise as arbitrary in claim 1 ?8 as described in medicine mixer;
Or comprise hard double nip as claimed in claim 9;
Described medicine mixer or described hard double nip are bonded together by described pedestal and described soft bag.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510781507.XA CN105232331B (en) | 2015-11-13 | 2015-11-13 | Medicine mixer, hard double nip and transfusion flexible bag |
| PCT/CN2016/105564 WO2017080522A1 (en) | 2015-11-13 | 2016-11-13 | Drug mixer, hard dual-port member, and soft infusion bag |
| KR1020187014837A KR102119990B1 (en) | 2015-11-13 | 2016-11-13 | Chemical mixing mixer, rigid dual pot and soft bag for fluids |
| CA3004927A CA3004927C (en) | 2015-11-13 | 2016-11-13 | Medication mixer, dual hard ports, and soft intravenous bag |
| US15/776,073 US20200253827A1 (en) | 2015-11-13 | 2016-11-13 | Drug mixer, hard dual-port member, and soft infusion bag |
| JP2018544393A JP2018535071A (en) | 2015-11-13 | 2016-11-13 | Drug mixer, hard dual interface and infusion softback |
| EP16863698.3A EP3375427B1 (en) | 2015-11-13 | 2016-11-13 | Drug mixer, hard dual-port member, and soft infusion bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510781507.XA CN105232331B (en) | 2015-11-13 | 2015-11-13 | Medicine mixer, hard double nip and transfusion flexible bag |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105232331A true CN105232331A (en) | 2016-01-13 |
| CN105232331B CN105232331B (en) | 2019-01-08 |
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| CN201510781507.XA Active CN105232331B (en) | 2015-11-13 | 2015-11-13 | Medicine mixer, hard double nip and transfusion flexible bag |
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| WO2017080522A1 (en) * | 2015-11-13 | 2017-05-18 | 重庆莱美药业股份有限公司 | Drug mixer, hard dual-port member, and soft infusion bag |
| WO2018010647A1 (en) * | 2016-07-11 | 2018-01-18 | 重庆莱美药业股份有限公司 | Machine for assembling medicine mixer |
| CN109044827A (en) * | 2018-07-25 | 2018-12-21 | 重庆莱美药业股份有限公司 | A kind of mixed medicine glass of achievable drug container replacement |
| CN109152698A (en) * | 2016-05-16 | 2019-01-04 | 美国血液技术公司 | Plasma bottle and its top cover without sealing element |
| US11648179B2 (en) | 2016-05-16 | 2023-05-16 | Haemonetics Corporation | Sealer-less plasma bottle and top for same |
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| US11648179B2 (en) | 2016-05-16 | 2023-05-16 | Haemonetics Corporation | Sealer-less plasma bottle and top for same |
| WO2018010647A1 (en) * | 2016-07-11 | 2018-01-18 | 重庆莱美药业股份有限公司 | Machine for assembling medicine mixer |
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| CN105232331B (en) | 2019-01-08 |
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