CN105228685A - Drug delivery airbag apparatus - Google Patents
Drug delivery airbag apparatus Download PDFInfo
- Publication number
- CN105228685A CN105228685A CN201480009200.1A CN201480009200A CN105228685A CN 105228685 A CN105228685 A CN 105228685A CN 201480009200 A CN201480009200 A CN 201480009200A CN 105228685 A CN105228685 A CN 105228685A
- Authority
- CN
- China
- Prior art keywords
- drug delivery
- air bag
- chamber
- airbag apparatus
- inaccessible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0059—Catheters; Hollow probes characterised by structural features having means for preventing the catheter, sheath or lumens from collapsing due to outer forces, e.g. compressing forces, or caused by twisting or kinking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Drug delivery airbag apparatus 100, wherein this drug delivery airbag apparatus comprises: at least two chambeies, first chamber 114 and the second chamber 116, airbag aeration hole 102, thread eye 110, drug delivery hole 108, inaccessible air bag 104, drug delivery air bag 106, the outer surface of drug delivery air bag 106 has multiple groove 140, wherein inaccessible air bag is disposed between drug delivery air bag and air bag air-filled pore, and inaccessible air bag is communicated with the first chamber with drug delivery air bag, one or more drug delivery passageway 120 extend the length in the second chamber, and one or more drug delivery tube 146 extends from one or more drug delivery passageway to the outer surface in the second chamber.
Description
Related application
This non-transitory patent application hereby claims, is filed on April 5th, 2013, and title is the U.S. Provisional Patent Application number 61/809176 of " drug delivery airbag apparatus and using method ", is incorporated to herein by reference at this with its entirety.
Background technology
Topical is the process being delivered to the specific region of the vascular system of human or animal patient by this process therapeutic agent.This topical therapeutic makes the concentration increase of predetermined target area Chinese medicine or therapeutic agent avoid to be caused by general systemic delivery the toxicity in blood circulation simultaneously.Known local administration method comprises DMG FirebirdTM or air bag, porous drug infusion air bag and the conveying of direct conduit
Summary of the invention
The present invention relates to for using drug delivery airbag apparatus to send medicinal liquid or the therapeutic agent method and apparatus to the selected position in vascular system.Drug delivery airbag apparatus of the present invention can advantageously allow can reach the balloon length of the increase of four times by the air bag more known than other, can be provided in the single course for the treatment of advantage for the treatment of compared with macrolesion position.Drug delivery airbag apparatus of the present invention can also provide multiple groove for receiving medicinal liquid during being delivered to destination path.What these grooves advantageously can guide medicinal liquid flows through destination channel, slows down medicine flowing to increase the time quantum that medicine contacts with the wall of destination channel simultaneously.Drug delivery airbag apparatus and relevant passage thereof can also contribute to making the capacity of the medicinal liquid occupied needed for a part for chamber capacity reduce to minimum.In addition, drug delivery airbag apparatus can also comprise inaccessible air bag, and inaccessible air bag can upwards inflate the pressure that makes to maintain system during infusing enough effectively to advance medicine or therapeutic agent to enter and along the groove on multiple drug delivery gasbag outer surface from drug delivery air bag.By the blood flow in blocking treatment region, inaccessible air bag helps prevent washing away of periphery in addition.
Therefore, in first aspect, the invention provides a kind of drug delivery airbag apparatus, it comprises: (a) at least two chambeies, it comprises the first chamber and the second chamber, b airbag aeration hole that () is communicated with the first chamber, c drug delivery hole that () is communicated with the second chamber, (d) and the second chamber any one thread eye be communicated with the 3rd chamber, (e) inaccessible air bag, (f) drug delivery air bag, wherein the outer surface of drug delivery air bag defines the groove that multiple first end from drug delivery air bag extends to the second end of drug delivery air bag, wherein inaccessible air bag is disposed between drug delivery air bag and air bag air-filled pore, wherein inaccessible air bag is communicated with the first chamber with drug delivery air bag, (G) drug delivery passageway of one or more extension second cavity length, (h) one or more drug delivery tube extending to the outer surface in the second chamber from one or more drug delivery passageway, and wherein one or more drug delivery tube are limited in the part in the second chamber, this part is disposed between inaccessible air bag and drug delivery air bag.
In one embodiment, the invention provides the multiple grooves can axially aligned with the central shaft of drug delivery air bag.In other embodiments various, multiple groove can be spiral, spiral, substantially straight, sinusoidal or cross-hatched, such as.Further, drug delivery hole can be dendritic make two kinds, three kinds in an example, four kinds or more plants different medicinal liquids or other solution be directed into drug delivery hole.
In another embodiment, the present invention can provide one or more drug delivery passageway, comprises four passages and each drug delivery passageway can be communicated with three drug delivery tube and makes to exist 12 drug delivery tube altogether.
In second aspect, present invention also offers for using drug delivery airbag apparatus, a kind of method of medicine is at least used to experimenter in need, the method comprises: (a) according to a first aspect of the invention, introduce drug delivery air bag to destination channel, b () is to inaccessible air bag and drug delivery airbag aeration, c () injects medicinal liquid to drug delivery hole, (d) medicinal liquid is advanced then to be entered and along multiple groove being limited to the outer surface of drug delivery air bag to the destination channel that one or more drug delivery tube enters experimenter by the second chamber.
Accompanying drawing explanation
Figure 1A is according to one embodiment of present invention, the side view of drug delivery airbag apparatus.
Figure 1B is according to one embodiment of present invention, the front section view of two chamber structures of drug delivery airbag apparatus.
Fig. 1 C is according to one embodiment of present invention, the front section view of three chamber structures of drug delivery airbag apparatus.
Fig. 1 D is according to one embodiment of present invention, the inaccessible air bag of drug delivery airbag apparatus and the side view of drug delivery air bag.
Fig. 1 E is according to one embodiment of present invention, the details sectional view of drug delivery air bag.
Fig. 2 depicts the flow chart according to the executable method of the example embodiment of disclosed method.
Detailed description of the invention
Illustrative methods and system describe in this article.Should be understood that, word " exemplary " is in this article for representing " as example, example or explanation ".Any be described as " exemplary " herein embodiment or feature not necessarily to be interpreted as being better than or surpassing other embodiments or feature.Exemplary embodiment described herein is not meant to be restrictive.It will readily appreciate that, some aspect of disclosed system and method can be arranged and combine in various different configuration widely, and all these are imagined at this.
In addition, the specific arrangements shown in figure should not be counted as restrictive.Should be understood that, other embodiments can comprise the element more more or less than each element in Given Graph.In addition, the element shown in some can be combined or omit.Further, exemplary embodiment can comprise the element do not illustrated in the drawings.
As used herein, relative to measurement, " about " refer to ± 5%.In addition, as used herein, " destination channel " refers to and wherein disposes drug delivery air bag effectively to use blood vessel or the tremulous pulse of medicinal liquid.Destination channel can also comprise artificial inner chamber, such as, as teaching aid.
In addition, as used herein, " medicinal liquid " refers to any flowable material that can be applied to destination channel.When medicinal liquid comprises the therapeutic agent being administered to experimenter, any suitable medicine that can be applied in the solution can be used.Can therapeutic agent comprise in various non-limiting example? sirolimus, heparin and stem-cell therapy; With antineoplastic agent, antibiotic medicine, anti-platelet agents, anticoagulant, Biciromab, antithrombase, antimitotic agent, antibiotic, agaist allergic symptoms medicine and antioxidant.Such antitumor drug and/or the example of antimitotic agent comprise paclitaxel, (such as, TAXOL.RTM is by Bristol-Myers Squibb Co., Stamford, Connecticut), Docetaxel (such as, Taxotere.RTM, from Frankfurt, Germany AventisSA), methotrexate, azathioprine, vincristine, vincaleucoblastine, fluorouracil, doxorubicin hydrochloride (such as, Adriamycin.RTM, from Pharmaci & Upjohn company, New Jersey skin Parker) and mitomycin (if Mutamycin.RTM is from Bristol-Myers Squibb Co., Stamford, Connecticut).The example of such anti-platelet agents, anticoagulant, Biciromab and antithrombase comprises aspirin, heparin sodium, low molecular weight heparin, heparinoid, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogue, glucosan, D-phenylalanine-PIO arginine-C chloromethyl ketone (synthesis antithrombase), persantin, glycoprotein iib/iiia platelet membrane receptor antagonist antibody, lepirudin 023 ludon and thrombin inhibitor such as captopril (biological heredity company, Cambridge, Massachusetts).The example of this cytostatics or anti-proliferative drugs comprises angiopeptin, angiotensin converting enzyme inhibitor is as captopril (such as, Capoten.RTM and Capozide.RTM is from Shi Guibao company limited Stamford, Connecticut), cilazapril or lisinopril (such as, Prinivil.RTM and Prinzide.RTM, from Merck Co., Ltd., station, the White House, New Jersey), calcium channel blocker (as nifedipine), Colchicine, protein, peptide, fibroblast growth factor (FGF) antagonist, fish oil (omega-3-fatty acid), histamine antagonist, lovastatin (brand is called Mevacor.RTM for HMG-CoA reductase inhibitor, pravastatin, and from the company of Merck & Co., Hai Tehaosi (hitehouse) stands, New Jersey), monoclonal antibody (as those are specific to platelet derived growth factor (PDGF) receptor), nitroprusside, phosphodiesterase inhibitor, prostaglandin inhibitor, suramin, serotonin blocker, steroid, protease inhibitor, triazolo pyrimidine (PDGF antagonist) and nitric oxide.The example of anti-allergic agent is Pemirolast Potassiu.Other therapeutic substance or reagent can be comprise platinum medicine, euglycemic agent, receptor tyrosine kinase inhibitors, carboplatin, alpha-interferon, genetically modified epithelial cell, non-steroidal anti-inflammatory agent non-steroidal anti-inflammatory agent, antiviral agent, anticarcinogen, anticoagulant, free radical scavenger, estradiol, antibiotic, nitric oxide donors, superoxide dismutase, superoxide dismutase mimics, 4-aminoacid-2,2,6,6-tetramethyl piperidine--1-oxygen base (4-aminoacid-TEMPQ), tacrolimus, dexamethasone.ABT-578, clobetasol, cytostatic agent and prodrug thereof, altogether medicine and their combination.Other therapeutic substance or reagent can comprise derivant or its functional analogue of rapamycin and structure, such as 40-O-(2-hydroxyl) ethyl rapamycin (known by the trade name of everolimus), 40-O-(3-hydroxyl base) propyl group-rapamycin, 40-O-[2-(2-hydroxyl) ethoxy] ethyl rapamycin, desmethyl-rapamycin and 40-O-tetrazolium rapamycin.In addition, non-therapeutic fluid, such as water, also can use, if the teaching model that using of drug conveying balloon-system or training demonstration, such as.
In first, the Exemplary drugs that Figure 1A shows according to one embodiment of present invention sends airbag apparatus 100.Drug delivery airbag apparatus 100 can comprise three holes: the airbag aeration hole 102 that (1) inflates to inaccessible air bag 104 and drug delivery air bag 106, (2) drug delivery hole 108, be applied by this hole medicinal liquid, (3) thread eye 110, for receiving seal wire and inaccessible air bag 104 and drug delivery air bag 106.In an example embodiment, as shown in Figure 1A, drug delivery port 108 can bifurcated, makes two kinds, three kinds, four kinds or more to plant different medicinal liquids or other solution be directed into drug delivery aperture 108, depending on treatment situation.
In one example, two parallel chambeies 112 are led in three holes.Figure 1B shows the cross-sectional view in two chambeies.This airbag apparatus 100 can comprise the first chamber 114 of being communicated with airbag aeration hole 102 and can be configured to receive saline contrast mixture, or other suitable fluid media (medium)s, inflates to give inaccessible air bag 104 and drug delivery air bag 106.And airbag apparatus 100 can comprise the second chamber 116 be communicated with thread eye 110 with drug delivery hole 108.In one embodiment, the second chamber can sizing and be shaped be suitable for receive medicinal liquid.In one embodiment, the second chamber 116 also can be dimensioned and be shaped to receive the seal wire of the diameter with the scope from about 0.25mm to about 1mm, and preferably in about 0.254mm extremely about 0.9652mm scope.In one embodiment, the first chamber 114 and the second chamber 116 can be loaded into sheath pipe 118.Second chamber 116 can comprise one or more drug delivery passageway 120 of extension second chamber 116 length.These drug delivery passageway 120 may be used for transmitting medicinal liquid from drug delivery hole 108 to destination channel.Second chamber 116 can also comprise the silk guide passage 122 of extension second cavity length.In another example, the second chamber 116 can comprise not only for seal wire but also for the single channel of medicinal liquid.
In such structure, seal wire can be removed after a procedure and make medicinal liquid can by the second chamber 116.In operation, the while that this airbag apparatus 100 can being configured to inject medicinal liquid, seal wire is in the second chamber 116.In such structure, the second chamber 116 has the diameter larger than seal wire, from the position between thread eye 110 and drug delivery hole 108 until lucky distally is in drug delivery tube 146.The far-end of air bag is arrived in the lucky distally of diameter narrowing down to about seal wire by the second chamber 116 in drug delivery tube 146.In addition, the second chamber 116 will narrow down to the diameter proximal of about seal wire in drug delivery hole 108, thus prevents medicinal liquid from leaving from thread eye 10.In another example, flange or unidirectional may be used for prevent medicinal liquid from leaving from thread eye 110.Other structures are also possible.
In another embodiment, three concentrically aligned outside chambeies 124 can be coupled in three holes.Such as.Fig. 1 C shows the elevational cross-sectional view in three chambeies 124.As is shown in fig. 1 c, three concentrically aligned outside chambeies 124 comprise inner chamber 126, intermediate cavity 128 and exocoel 130, and wherein the first chamber is arranged to inner chamber, and the second chamber is arranged as intermediate cavity and the 3rd chamber is arranged as exocoel.Inner chamber 126 can be communicated with thread eye 110 and can be dimensioned and be shaped to receive and has the seal wire of diameter of about 0.25mm to about 1mm scope, preferably from about 0.254mm to the scope of about 0.9652mm.Intermediate cavity 128 can be communicated with drug delivery hole 108.Intermediate cavity 128 can comprise multiple flexible spacer 132 extended between inner chamber 126 and exocoel 130 to keep the structural intergrity of intermediate cavity 128.These septs 132, are combined with intermediate cavity 128 and inner chamber 126, can limit the drug delivery passageway 134 of one or more extension intermediate cavity 128 length further.As mentioned above, these drug delivery passageway 134 may be used for transmitting medicinal liquid from drug delivery hole 108 to destination channel.Exocoel 130 can be communicated with airbag aeration hole 102.Exocoel 130 also can comprise multiple flexible spacer 136 to contribute to keeping the structural intergrity of exocoel 130.These septs 136 also can limit the liquid delivery passage 138 of the length of multiple extension exocoel 130 in conjunction with exocoel 130 and intermediate cavity 128.These liquid delivery passages 138 are communicated with drug delivery air bag 106 fluid with inaccessible air bag 104.
Fig. 1 D shows inaccessible air bag 104 and the drug delivery balloon 106 of drug delivery airbag apparatus 100.Inaccessible air bag 104 can be made up of such as polyurethane, latex or polysiloxanes atraumatic, compatible material, in other probabilities, cause the material of about 5 atmospheric low burst pressures, such as.But inaccessible air bag 104 can be configured to bear larger pressure, such as, up to about 20 atmospheric pressure.Through low inflation, about 1 to 2 atmospheric pressure, inaccessible air bag 104 can be configured to the size and the size that meet destination channel.Once inflation, inaccessible air bag can provide obturation to make drug delivery target approach passage in destination channel, goes downstream to reduce blood flow to the dilution of medicinal liquid from inaccessible air bag 104 as far as possible.The diameter of the inaccessible air bag after inflation can at about 2.5mm to 12mm range changing and preferably in the scope of about 2.5mm to about 6mm.The length of inaccessible air bag can change at about 20mm to about 40mm.In one embodiment, the inflated diameter of inaccessible air bag 104 changes from the long 2mm of about identical with the inflated diameter of drug delivery air bag 106 diameter to the inflation than drug delivery air bag 106.In operation, inaccessible air bag 104 can be inflated before introducing medicinal liquid enters drug delivery hole 108.
Drug delivery air bag 106 such as can cause about 5 air to force down the polyurethane of burst pressure, latex or polysiloxanes by compatible material, such as.The length of drug delivery air bag 106 can change from about 20mm to about 200mm.In various embodiments, the length of drug delivery air bag 106 is from about 80mm to about 200mm, about 100mm to about 200mm, about 12mm to about 200mm, from about 140mm to about 200mm, from about 160mm to about 200mm, from about 180mm to about 200mm, from about 60mm to about 120mm, about 60mm to about 100mm and changing from about 10mm to about 80mm.An embodiment, drug delivery air bag 106 can have the scope from about 2.5mm to about 12mm inflated diameter and preferably from about 2.5mm to the scope of about 6mm.In various embodiments, the inflated diameter of drug delivery air bag 106 from about 2.5mm to 3mm, can change from about 4mm to about 5mm with from 5mm to about 6mm.
The outer surface of drug delivery air bag 106 can limit multiple groove 140 for receiving medicinal liquid.These grooves 140 can extend to the second end 144 of drug delivery air bag 106 from the first end 142 of drug delivery air bag 106.Multiple groove 140 can be used as the time that (1) guides the flowing of medicinal liquid to contact with the wall of destination channel to increase medicine with the flowing that (2) slow down medicinal liquid.Multiple groove 140 central axis that is preferred and drug delivery air bag 106 axially aligns.And can be spiral, spiral, sinusoidal or substantially straight, in other probability, in various embodiment.Spiral, spiral or the groove of sine be better than straight groove, because more tortuous groove provides larger surface area contact blood vessel wall and extend the time quantum of medicinal liquid contact blood vessel wall further.In addition, the groove of any pattern is expection, comprises cross-hatched or Waffle pattern, such as.
Inaccessible air bag 104 can be disposed between drug delivery air bag 106 and air bag air-filled pore 102 and make inaccessible air bag 104 can be communicated with the second chamber or exocoel 130 with drug delivery air bag 106 and receive the fluid from airbag aeration hole 102.Inaccessible air bag 104 and drug delivery air bag 106 can be separated from each other by from about 1mm to the distance of about 10mm, and preferably from about 3mm to about 5mm.This distance allows enough pressure to keep in systems in which medicinal liquid can be entered into effectively and along multiple groove 140 on the outer surface of drug delivery air bag 106.
One or more drug delivery pipeline 146 can extend to the outer surface in the second chamber 116 from one or more drug delivery passageway 120 be defined in the second chamber 116.These drug delivery tube 146 can be limited in the part 148 in the second chamber 116, and it is disposed between inaccessible air bag 104 and drug delivery air bag 106.In other words, these drug delivery tube 130 can go downstream from inaccessible air bag 104, in operation.In one embodiment, one or more drug delivery passageway 120 can comprise four to eight passages.In another embodiment, the respective of one or more drug delivery passageway 120 is communicated with one to six drug delivery tube 146 fluid.In a further embodiment, one or more drug delivery passageway 120 can comprise four passages and each drug delivery passageway can be communicated with glibly with three drug delivery tube and makes to exist 12 drug delivery tube altogether.The number of drug delivery tube can depend on the length of the part 148 in the second chamber 116, and it extends between inaccessible air bag 104 and the diameter of drug delivery air bag 106 and/or drug delivery tube 146, in other probabilities.
Fig. 1 E shows the cross-sectional side view of drug delivery air bag 106.As referring to figure 1e, drug delivery air bag 106 comprises multiple groove 140.In operation, medicinal liquid advances downwards and to enter and along the groove 140 in multiple outer surface being limited to drug delivery air bag 106.Once medicinal liquid leaves multiple groove 140 at the second end 144 of drug delivery air bag 106, medicinal liquid can be eliminated by natural arterial blood flow and ultimate physiological function.
Fig. 2 is the simplified flow chart of the method illustrated according to one exemplary embodiment.Although frame illustrates with order in succession, these frames also can perform concurrently and/or to be different from order described herein.In addition, each frame can be combined into less frame, is divided into additional frame, and/or is removed according to desired realization.
At frame 202, the method relates to according to any one embodiment aforesaid, introduces drug delivery airbag apparatus to destination channel.Drug delivery airbag apparatus can in standard coaxial mode, by line or rapid ex change techniques, as an example, is introduced into.
At frame 204, the method relates to inaccessible air bag and drug delivery airbag aeration.In one embodiment, inaccessible air bag and drug delivery air bag can enter airbag aeration hole to inflate by pump pickle control mixture, such as.Then saline contrast mixture can proceed to inaccessible air bag and drug delivery air bag until two air bags are all inflated by the first chamber.Inaccessible air bag can with speed inflation a little faster, because inaccessible air bag and drug delivery air bag are connected in series to make inaccessible air bag first receive saline control mixture.In another embodiment, inaccessible air bag and drug delivery air bag can use any other suitable fluid media (medium) to inflate.
All be filled with air at inaccessible air bag and drug delivery air bag, the method proceeds to frame 206, injects medicinal liquid in drug delivery hole.Drug delivery hole is bifurcated in one embodiment, two kinds, three kinds, four kinds or more different types of medicinal liquids or other solution is directed in drug delivery hole, depend on the circumstances.
At frame 208, the method relates to the destination channel advancing medicinal liquid to be entered experimenter to one or more drug delivery tube by the second chamber.In this stage, the space between inaccessible air bag and drug delivery air bag is used as the container storing medicinal liquid, when medicinal liquid is delivered by drug delivery tube.Because medicinal liquid is just being introduced in the pressure in drug delivery hole, medicinal liquid advances downwards and to enter and along multiple groove being defined in drug delivery gasbag outer surface.The pressure using medicinal liquid should not exceed about 2 atmospheric pressure.Once medicinal liquid leaves multiple groove at the second end of drug delivery air bag, medicinal liquid can be removed by normal artery blood flow and ultimate physiological function.
Although various aspect and embodiment are open at this, other aspects and embodiment will be apparent for those those skilled in the art in this area.In the different aspect of this aspect and between all embodiments can be combined unless the context.Respective aspect disclosed herein and embodiment are intended to illustrate, and are not intended to be restrictive to have the real scope and spirit just indicated by following claim.
Claims (21)
1. a drug delivery airbag apparatus, comprising:
At least two chambeies, comprise the first chamber and the second chamber;
The airbag aeration hole be communicated with described first chamber;
The drug delivery hole be communicated with described second chamber;
The thread eye be communicated with described second chamber or the 3rd chamber;
Inaccessible air bag;
Drug delivery air bag, the outer surface of wherein said drug delivery air bag defines the groove that multiple first end from described drug delivery air bag extends to the second end of described drug delivery air bag, wherein said inaccessible air bag is disposed between described drug delivery air bag and described airbag aeration hole, and wherein said inaccessible air bag is communicated with described first chamber with described drug delivery air bag;
The drug delivery passageway of the length in described second chamber of one or more extension; With
One or more drug delivery tube extending to the outer surface in described second chamber from described one or more drug delivery passageway, and wherein said one or more drug delivery tube is only defined in the part in described second chamber, and this part is disposed between described inaccessible air bag and described drug delivery air bag.
2. drug delivery airbag apparatus as claimed in claim 1, wherein said thread eye is communicated with described second chamber.
3. drug delivery airbag apparatus as claimed in claim 1, also comprise the 3rd chamber, wherein said thread eye is communicated with described 3rd chamber, wherein said first chamber, described second chamber and described 3rd chamber concentric alignment make described 3rd chamber be arranged to inner chamber, and described second chamber is arranged to intermediate cavity and described first chamber is arranged to exocoel.
4. the drug delivery airbag apparatus as described in any one in claim 1-3, the central shaft of wherein said multiple groove and described drug delivery air bag axially aligns.
5. the drug delivery airbag apparatus as described in any one in claim 1-4, wherein said multiple groove be spiral, spiral, substantially straight or sine.
6. the drug delivery airbag apparatus as described in any one in claim 1-5, wherein said multiple groove is cross-hatched.
7. the drug delivery airbag apparatus as described in any one in claim 1-6, wherein said inaccessible air bag and described drug delivery air bag are separated from each other by the distance of the scope from about 3mm to about 5mm.
8., as the drug delivery airbag apparatus in claim 1-7 as described in any one, wherein said drug delivery hole is bifurcated.
9., as the drug delivery airbag apparatus in claim 1-8 as described in any one, wherein said inaccessible air bag and described drug delivery air bag have from about 2.5mm to the diameter of about 12mm scope separately.
10., as the drug delivery airbag apparatus in claim 1-9 as described in any one, the inflated diameter of wherein said inaccessible air bag changes from about identical with the inflated diameter of described drug delivery air bag to than the about long 2mm of described drug delivery air bag.
11. drug delivery airbag apparatus as described in any one in claim 1-10, the length of wherein said inaccessible air bag changes from about 20mm to about 40mm.
12. as the drug delivery airbag apparatus in claim 1-11 as described in any one, and the length of wherein said drug delivery air bag changes from about 50mm to about 200mm.
13. as the drug delivery airbag apparatus in claim 1-12 as described in any one, and the length of wherein said drug delivery air bag is about 200mm.
14. as the drug delivery airbag apparatus in claim 1-13 as described in any one, and wherein said thread eye is dimensioned to receive the seal wire of the diameter had in about 0.254mm to 0.9652mm scope.
15. as the drug delivery airbag apparatus in claim 1-14 as described in any one, and wherein said one or more drug delivery passageway comprises four to eight passages.
16. drug delivery airbag apparatus as described in any one in claim 1-15, wherein said one or more drug delivery passageway is communicated with one to six drug delivery tube fluids separately.
17. as the drug delivery airbag apparatus in claim 1-16 as described in any one, and wherein said one or more drug delivery passageway comprises four passages and each drug delivery passageway is communicated with three drug delivery tube so that there are 12 drug delivery tube altogether.
18. 1 kinds of methods, use drug delivery airbag apparatus to be used at least using a kind of medicine to experimenter in need, described method comprises:
Introduce as in the drug delivery airbag apparatus target approach passage in claim 1-17 as described in any one;
To described inaccessible air bag and described drug delivery airbag aeration;
Inject medicinal liquid in described drug delivery hole; And
Medicinal liquid is advanced to be entered in experimenter's destination channel to described one or more drug delivery tube by described second chamber and then to enter and along the multiple grooves in the outer surface being defined in described drug delivery air bag.
19. methods as claimed in claim 18, wherein inject medicinal liquid 2 atmospheric pressure or lower than 2 atmospheric fluid pressures under perform.
20. methods as described in claim 18 or 19, the inflated diameter of wherein said inaccessible air bag changes from about identical with the inflated diameter of described drug delivery air bag to than the about long 2mm of described drug delivery air bag.
21. as the method in claim 18-20 as described in any one, comprises wherein to described inaccessible air bag and described drug delivery airbag aeration:
Inject saline control mixture to described airbag aeration hole; And
Described saline control mixture is advanced to arrive described inaccessible air bag and described drug delivery air bag by least one of two chambeies.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809176P | 2013-04-05 | 2013-04-05 | |
| US61/809,176 | 2013-04-05 | ||
| PCT/US2014/032964 WO2014165751A1 (en) | 2013-04-05 | 2014-04-04 | Drug delivery balloon apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105228685A true CN105228685A (en) | 2016-01-06 |
Family
ID=51033464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480009200.1A Pending CN105228685A (en) | 2013-04-05 | 2014-04-04 | Drug delivery airbag apparatus |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2981323A1 (en) |
| JP (1) | JP2016515433A (en) |
| KR (1) | KR20160005674A (en) |
| CN (1) | CN105228685A (en) |
| AU (1) | AU2014248069A1 (en) |
| BR (1) | BR112015019493A2 (en) |
| CA (1) | CA2901178C (en) |
| HK (1) | HK1219447A1 (en) |
| WO (1) | WO2014165751A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014348345A1 (en) * | 2013-11-18 | 2016-06-02 | Roger Andersen | Method of sinusitis treatment |
| US11690981B2 (en) | 2017-03-07 | 2023-07-04 | Sanford Health | Infusion balloon and methods for use thereof |
| KR102570767B1 (en) | 2023-02-21 | 2023-08-24 | 최은경 | Front wedge for pre-tensioning rock bolt |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5207648A (en) * | 1990-12-14 | 1993-05-04 | The Kendall Company | Multilumen catheter |
| US5704361A (en) * | 1991-11-08 | 1998-01-06 | Mayo Foundation For Medical Education And Research | Volumetric image ultrasound transducer underfluid catheter system |
| US6685672B1 (en) * | 2000-07-13 | 2004-02-03 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
| WO2004037178A2 (en) * | 2002-10-21 | 2004-05-06 | Bacchus Vascular Inc. | Apparatus and methods for clot dissolution |
| US20070088317A1 (en) * | 2002-06-27 | 2007-04-19 | Hyde Gregory M | Catheters and methods of using catheters |
| JP2010158483A (en) * | 2009-01-09 | 2010-07-22 | Kaneka Corp | Balloon catheter equipped with attachable/detachable liquid injection tube for balloon dilation |
| US20110152683A1 (en) * | 2011-03-01 | 2011-06-23 | Gerrans Lawrence J | Abrading Balloon Catheter for Extravasated Drug Delivery |
| US8182446B2 (en) * | 2007-09-12 | 2012-05-22 | Cook Medical Technologies | Balloon catheter for delivering a therapeutic agent |
| CN102600546A (en) * | 2011-03-01 | 2012-07-25 | 劳伦斯.J.格兰斯 | Nested balloon catheter for localized drug delivery |
| US20120316436A1 (en) * | 2011-06-10 | 2012-12-13 | Cook Medical Technologies Llc | Balloon catheter with three lumens |
-
2014
- 2014-04-04 WO PCT/US2014/032964 patent/WO2014165751A1/en active Application Filing
- 2014-04-04 JP JP2016506643A patent/JP2016515433A/en active Pending
- 2014-04-04 AU AU2014248069A patent/AU2014248069A1/en not_active Abandoned
- 2014-04-04 EP EP14734261.2A patent/EP2981323A1/en not_active Withdrawn
- 2014-04-04 CN CN201480009200.1A patent/CN105228685A/en active Pending
- 2014-04-04 CA CA2901178A patent/CA2901178C/en not_active Expired - Fee Related
- 2014-04-04 KR KR1020157019992A patent/KR20160005674A/en not_active Application Discontinuation
- 2014-04-04 BR BR112015019493A patent/BR112015019493A2/en not_active IP Right Cessation
-
2016
- 2016-06-28 HK HK16107530.4A patent/HK1219447A1/en unknown
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5207648A (en) * | 1990-12-14 | 1993-05-04 | The Kendall Company | Multilumen catheter |
| US5704361A (en) * | 1991-11-08 | 1998-01-06 | Mayo Foundation For Medical Education And Research | Volumetric image ultrasound transducer underfluid catheter system |
| US6685672B1 (en) * | 2000-07-13 | 2004-02-03 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
| US20070088317A1 (en) * | 2002-06-27 | 2007-04-19 | Hyde Gregory M | Catheters and methods of using catheters |
| WO2004037178A2 (en) * | 2002-10-21 | 2004-05-06 | Bacchus Vascular Inc. | Apparatus and methods for clot dissolution |
| US8182446B2 (en) * | 2007-09-12 | 2012-05-22 | Cook Medical Technologies | Balloon catheter for delivering a therapeutic agent |
| JP2010158483A (en) * | 2009-01-09 | 2010-07-22 | Kaneka Corp | Balloon catheter equipped with attachable/detachable liquid injection tube for balloon dilation |
| US20110152683A1 (en) * | 2011-03-01 | 2011-06-23 | Gerrans Lawrence J | Abrading Balloon Catheter for Extravasated Drug Delivery |
| CN102600546A (en) * | 2011-03-01 | 2012-07-25 | 劳伦斯.J.格兰斯 | Nested balloon catheter for localized drug delivery |
| US20120316436A1 (en) * | 2011-06-10 | 2012-12-13 | Cook Medical Technologies Llc | Balloon catheter with three lumens |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015019493A2 (en) | 2017-07-18 |
| HK1219447A1 (en) | 2017-04-07 |
| KR20160005674A (en) | 2016-01-15 |
| AU2014248069A1 (en) | 2015-07-30 |
| CA2901178C (en) | 2018-05-01 |
| CA2901178A1 (en) | 2014-10-09 |
| WO2014165751A1 (en) | 2014-10-09 |
| EP2981323A1 (en) | 2016-02-10 |
| JP2016515433A (en) | 2016-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12076512B2 (en) | Fluid delivery balloon apparatus and methods for use | |
| ES2960088T3 (en) | Controlled porosity devices for fabric treatments and manufacturing methods | |
| US8740844B2 (en) | Medical device with drug delivery member | |
| US20100082012A1 (en) | Double balloon catheter and methods for homogeneous drug delivery using the same | |
| AU2010295415B2 (en) | Biologics infusion system | |
| JP2011509158A5 (en) | ||
| US8568354B2 (en) | Devices and methods for low shearing local delivery of therapeutic agents to the wall of a bodily lumen | |
| US20190091438A1 (en) | Catheter with side ports and methods of use | |
| CN105228685A (en) | Drug delivery airbag apparatus | |
| CN102470196A (en) | Medical device for drug delivery | |
| US20230347114A1 (en) | Infusion Balloon and Methods for Use Thereof | |
| US20210386979A1 (en) | Balloon catheter system for infusion of micelles at high pressure | |
| US7396351B2 (en) | Device and method for the delivery of viscous fluids in the body | |
| US20130230576A1 (en) | Microlayer coextrusion to create a time-release drug |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160106 |
|
| WD01 | Invention patent application deemed withdrawn after publication |