CN105214093B - A kind of compound recipe micro-glue wound healing conditioning liquid - Google Patents
A kind of compound recipe micro-glue wound healing conditioning liquid Download PDFInfo
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- CN105214093B CN105214093B CN201510784777.6A CN201510784777A CN105214093B CN 105214093 B CN105214093 B CN 105214093B CN 201510784777 A CN201510784777 A CN 201510784777A CN 105214093 B CN105214093 B CN 105214093B
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Abstract
The invention discloses a kind of compound recipe micro-glue wound healing conditioning liquid, its one-tenth is grouped into: benzoflavine 0.5～2.0%, polymyxin 2.0～7.0%, novocain 0.01～0.1%, molecule distillating monoglyceride 1.0～2.0%, polyvinylpyrrolidone 0.5～2.0%, ethanol 1.0～10.0%, somatomedin 0.01～0.05%, healing factor 0.2～0.8%, buffer 0.08～3.0%, preservative 0.02～0.5%, antioxidant 0.01～0.3%, stabilizer 0.01～0.1%, colloid plasticizer 0.2～1.6%, surplus are water for injection；The present invention has the most antibacterial, antiinflammatory, anti-infectious function, effectively facilitates cell growth, accelerating wound healing, prevents cicatrization, antiallergic, and drug effect gentleness is stable, has no adverse reaction, various wounds are respectively provided with general applicability.
Description
Technical field
The present invention relates to technology medicine nursing field, be specifically related to a kind of compound recipe micro-glue wound healing conditioning liquid.
Background technology
Wound healing is the process of more answering after fracture and defect occur in the tissues such as skin, and this is a complicated disease
Reason process, including regeneration and the hypertrophy of granulation tissue, the cicatrization of various tissues.Its basis is that inflammation is thin
Born of the same parents and a series of activities of repair cell.In soft tissue injury, main inflammatory cell includes: monokaryon is huge
Phagocyte, neutrophilic granulocyte, lymphocyte etc.；Main repair cell includes: fibroblast, endothelium
Cell, epidermis cell etc..The activity of these cells is affected by locally and systemically factor.According to wound healing
The modern theory closed, multiple circulatory mediator and cell medium all can affect the behavior of inflammatory cell and repair cell,
Thus participate in wound healing process.
Therefore, to start with from many aspects for wound healing, the most antibacterial, antiinflammatory is inadequate, also wants energy
Promoting cell tissue growth, accelerate its healing, also want energy infection, antiallergic, common wound healing protects
Reason liquid does not reaches so many function, and therefore, using effect is the most general.The most maximum problem is, respectively
Kind of Wound care product has certain limitation, and being only used for of scald is scalded, and being only used for of burn is burnt
Wound so that various Wound care products are miscellaneous and many, manufactures complexity, it is therefore desirable to develop a kind of tool
There is the care drug for wound care of general applicability.
Summary of the invention
Present invention solves the technical problem that and be to provide a kind of compound recipe micro-glue wound healing conditioning liquid, this conditioning liquid can have
Effect promotes cell growth, accelerating wound healing, moreover it is possible to prevent cicatrization, the sense caused for various wounds
Dye, ulcer, abscess etc., have general applicability.
For solving above-mentioned technical problem, the technical solution adopted in the present invention is as follows:
A kind of compound recipe micro-glue wound healing conditioning liquid, its one-tenth is grouped into: benzoflavine 0.5～2.0%, many Acarasiales
Element 2.0～7.0%, novocain 0.01～0.1%, molecule distillating monoglyceride 1.0～2.0%, polyethylene pyrrole
Pyrrolidone 0.5～2.0%, ethanol 1.0～10.0%, somatomedin 0.01～0.05%, healing factor 0.2～
0.8%, buffer 0.08～3.0%, preservative 0.02～0.5%, antioxidant 0.01～0.3%, stable
Agent 0.01～0.1%, colloid plasticizer 0.2～1.6%, surplus are water for injection.Described polymyxin is many
Colistin A, Polymyxin C or polymyxin E.
Further, described somatomedin is epidermal growth factor (EGF), basic fibroblast growth factor
(FGF), keratinocyte growth factor (KGF), transforminggrowthfactor-α (TGF-α) or Peritoneal fibrosis
Any one or a few combination in β (TGF-β).
Further, described healing factor is any one in hyaluronic acid, glucosamine or allantoin,
Can accelerating wound healing.
Further, described buffer is Tris-phosphate buffer, buffered with amino acid liquid, GOOD buffering
Any one in liquid, buffer has the effect hindering pH value of solution change.
Further, described preservative is sorbic acid and its esters or parabens, presses down under sour environment
Bacterium and favorable anti-corrosion effect.
Further, described antioxidant is superoxide dismutase, and superoxide dismutase is that one comes from
The active substance of life entity, can eliminate the harmful substance that organism produces in metabolic processes.
Further, described stabilizer is D-trehalose, prevents ingredient from inactivating.
Further, described colloid plasticizer is poloxamer188, and poloxamer188 is tasteless, is soluble in
Water and ethanol, also have preferable surface activity, and topical has preferable using effect.
Further, described a kind of compound recipe micro-glue wound healing conditioning liquid, its preparation method is: by molecular distillation
Monoglyceride joins in water for injection by the part by weight of 1:10～20, is heated to 60～70 DEG C, stirs molten
Solve, make hydration monoglyceride, be cooled to room temperature, add buffer, stir under 400～500rpm
5～10min, add benzoflavine, polymyxin, novocain, polyvinylpyrrolidone, ethanol,
Somatomedin, healing factor, preservative, antioxidant, stabilizer and surplus water for injection, 600
Stir 20～30min under rpm, form homogeneous mixture, adjust ph with the phosphoric acid that mass fraction is 0.8%
Value, to 5.5～6.0, is eventually adding colloid plasticizer, stirs 30～60min under 200～400rpm,
?.
The invention has the beneficial effects as follows: compound recipe micro-glue wound healing conditioning liquid of the present invention has the most antibacterial, anti-
Scorching, anti-infectious function, it is possible to effectively facilitate cell growth, accelerating wound healing, remove free radical, moreover it is possible to
Prevent cicatrization, and can antiallergic, drug effect is gentle and stablizes, and has no adverse reaction, for various wounds
The infection that causes, mucosa injury, ulcer, abscess etc., have general applicability.
Detailed description of the invention
Embodiment 1:
A kind of compound recipe micro-glue wound healing conditioning liquid, its one-tenth is grouped into: benzoflavine 0.5%, polymyxin 2.0%,
Novocain 0.01%, molecule distillating monoglyceride 1.0%, polyvinylpyrrolidone 0.5%, ethanol 1.0%, life
The long factor 0.01%, healing factor 0.2%, buffer 0.08%, preservative 0.02%, antioxidant 0.01%,
Stabilizer 0.01%, colloid plasticizer 0.2%, surplus are water for injection.Described polymyxin is polymyxin
A, Polymyxin C or polymyxin E.
Wherein, described somatomedin is epidermal growth factor (EGF), basic fibroblast growth factor
(FGF), keratinocyte growth factor (KGF), transforminggrowthfactor-α (TGF-α) or Peritoneal fibrosis
Any one or a few combination in β (TGF-β)；Described healing factor is hyaluronic acid, aminoglucose
Sugar or allantoin in any one, can accelerating wound healing；Described buffer is Tris-phosphate-buffered
Any one in liquid, buffered with amino acid liquid, GOOD buffer, buffer has obstruction pH value of solution change
Effect；Described preservative is sorbic acid and its esters or parabens, antibacterial and anti-under sour environment
Rotten effective；Described antioxidant is superoxide dismutase, and superoxide dismutase is that one comes from life
The active substance of body, can eliminate the harmful substance that organism produces in metabolic processes；Described stabilizer
For D-trehalose, prevent ingredient from inactivating；Described colloid plasticizer is poloxamer188, poloxamer
407 is tasteless, soluble in water and ethanol, also has preferable surface activity, and topical has preferably use
Effect.
The preparation method of this compound recipe micro-glue wound healing conditioning liquid is: by molecule distillating monoglyceride by the weight of 1:10
Ratio joins in water for injection, is heated to 60 DEG C, and stirring and dissolving is made hydration monoglyceride, is cooled to
Room temperature, add buffer, under 400rpm stir 5min, add benzoflavine, polymyxin,
Novocain, polyvinylpyrrolidone, ethanol, somatomedin, healing factor, preservative, antioxidant,
Stabilizer and surplus water for injection, stir 20min at 600 rpm, forms homogeneous mixture, uses matter
Amount mark be 0.8% phosphoric acid adjust ph value to 5.5, be eventually adding colloid plasticizer, at 200 rpm
Stirring 30min,.
Embodiment 2:
A kind of compound recipe micro-glue wound healing conditioning liquid, its one-tenth is grouped into: benzoflavine 1.25%, polymyxin
4.5%, novocain 0.55%, molecule distillating monoglyceride 1.5%, polyvinylpyrrolidone 1.25%, ethanol
5.5%, somatomedin 0.03%, healing factor 0.5%, buffer 1.54%, preservative 0.26%, antioxidation
Agent 0.155%, stabilizer 0.055%, colloid plasticizer 0.9%, surplus are water for injection.Described many Acarasiales
Element is aerosporin, Polymyxin C or polymyxin E.
Wherein, described somatomedin is epidermal growth factor (EGF), basic fibroblast growth factor
(FGF), keratinocyte growth factor (KGF), transforminggrowthfactor-α (TGF-α) or Peritoneal fibrosis
Any one or a few combination in β (TGF-β)；Described healing factor is hyaluronic acid, aminoglucose
Sugar or allantoin in any one, can accelerating wound healing；Described buffer is Tris-phosphate-buffered
Any one in liquid, buffered with amino acid liquid, GOOD buffer, buffer has obstruction pH value of solution change
Effect；Described preservative is sorbic acid and its esters or parabens, antibacterial and anti-under sour environment
Rotten effective；Described antioxidant is superoxide dismutase, and superoxide dismutase is that one comes from life
The active substance of body, can eliminate the harmful substance that organism produces in metabolic processes；Described stabilizer
For D-trehalose, prevent ingredient from inactivating；Described colloid plasticizer is poloxamer188, poloxamer
407 is tasteless, soluble in water and ethanol, also has preferable surface activity, and topical has preferably use
Effect.
The preparation method of this compound recipe micro-glue wound healing conditioning liquid is: by molecule distillating monoglyceride by the weight of 1:15
Ratio joins in water for injection, is heated to 65 DEG C, and stirring and dissolving is made hydration monoglyceride, is cooled to
Room temperature, add buffer, stir 7.5min at 450 rpm, add benzoflavine, polymyxin,
Novocain, polyvinylpyrrolidone, ethanol, somatomedin, healing factor, preservative, antioxidant,
Stabilizer and surplus water for injection, stir 25min at 600 rpm, forms homogeneous mixture, uses matter
Amount mark be 0.8% phosphoric acid adjust ph value to 5.5, be eventually adding colloid plasticizer, at 300 rpm
Stirring 45min,.
Embodiment 3:
A kind of compound recipe micro-glue wound healing conditioning liquid, its one-tenth is grouped into: benzoflavine 2.0%, polymyxin 7.0%,
Novocain 0.1%, molecule distillating monoglyceride 2.0%, polyvinylpyrrolidone 2.0%, ethanol 10.0%, life
The long factor 0.05%, healing factor 0.8%, buffer 3.0%, preservative 0.5%, antioxidant 0.3%,
Stabilizer 0.1%, colloid plasticizer 1.6%, surplus are water for injection.Described polymyxin be aerosporin,
Polymyxin C or polymyxin E.
Wherein, described somatomedin is epidermal growth factor (EGF), basic fibroblast growth factor
(FGF), keratinocyte growth factor (KGF), transforminggrowthfactor-α (TGF-α) or convert growth because of
Any one or a few combination in son-β (TGF-β)；Described healing factor is hyaluronic acid, amino
Any one in glucose or allantoin, can accelerating wound healing；Described buffer is Tris-phosphate
Any one in buffer, buffered with amino acid liquid, GOOD buffer, buffer has obstruction pH value of solution
The effect of change；Described preservative is sorbic acid and its esters or parabens, antibacterial under sour environment
And favorable anti-corrosion effect；Described antioxidant is superoxide dismutase, and superoxide dismutase is that one comes from
The active substance of life entity, can eliminate the harmful substance that organism produces in metabolic processes；Described surely
Determining agent is D-trehalose, prevents ingredient from inactivating；Described colloid plasticizer is poloxamer188, moors Lip river
Husky nurse 407 is tasteless, and soluble in water and ethanol also has preferable surface activity, and topical has preferably
Using effect.
The preparation method of this compound recipe micro-glue wound healing conditioning liquid is: by molecule distillating monoglyceride by the weight of 1:20
Ratio joins in water for injection, is heated to 70 DEG C, and stirring and dissolving is made hydration monoglyceride, is cooled to
Room temperature, add buffer, stir 10min at 500 rpm, add benzoflavine, polymyxin,
Novocain, polyvinylpyrrolidone, ethanol, somatomedin, healing factor, preservative, antioxidant,
Stabilizer and surplus water for injection, stir 30min at 600 rpm, forms homogeneous mixture, uses matter
Amount mark be 0.8% phosphoric acid adjust ph value to 6.0, be eventually adding colloid plasticizer, under 400rpm
Stirring 60min,.
Experimental verification:
1, experimental subject: taking healthy mice 160, body weight is 1.20 ± 0.1kg, is divided into 8 groups,
Often group 20, is designated as 1 group, 2 groups, 3 groups, 4 groups, 5 groups, 6 groups, 7 groups, 8 groups respectively.
2, experimental technique:
Mice processes: shave out the square region of 3 × 3cm at every mouse web portion, 1 group and 5 groups is burnt with ironware
Wound, 2 groups and 6 groups are hurt with sharp weapon, scald with boiled water for 3 groups and 7 groups, and 4 groups and 8 groups are damaged with ionizing radiation
Wound, all above damage is only limitted in described square region.
Therapeutic scheme: 8 groups of mices are treated according to medical science conventional treatments respectively, on this basis,
To 1 group, 2 groups, 3 groups, the mice of 4 groups use compound recipe micro-glue wound healing conditioning liquid of the present invention to process,
5 groups, 6 groups, 7 groups, 8 groups as comparison, observe wound healing situation.
3, Comparative result:
1 group, 2 groups, 3 groups, mice wound healing ratio average time 5 groups, 6 groups, 7 groups, 8 groups of 4 groups
Mice wound healing take short 13 days average time；1 group, 2 groups, 3 groups, the mice wound of 4 groups is without infecting
Phenomenon, and 5 groups, 6 groups, 7 groups, the mice wound major part of 8 groups occur in that infection in various degree；1
Group, 2 groups, 3 groups, after the mice wound healing of 4 groups all without cicatrix, and 5 groups, 6 groups, 7 groups, 8 groups have
Different size of cicatrix is left after the mice wound healing of 4/5ths；It addition, 1 group, 2 groups, 3 groups, 4
All there is not untoward reaction in the mice of group.
4, conclusion: be may certify that by above experiment, compound recipe micro-glue wound healing conditioning liquid of the present invention is for various
Wound all has and preferably promotes Healing, and can prevent from infecting, preventing from scar, has general applicability,
And safely and effectively, have no side effect.
Last it is noted that above example is only in order to illustrate technical scheme, rather than it is limited
System；Although the present invention being described in detail with reference to previous embodiment, those of ordinary skill in the art
It is understood that the technical scheme described in previous embodiment still can be modified by it, or to wherein
Portion of techniques feature carries out equivalent；And these amendments or replacement, do not make the basis of appropriate technical solution
Matter departs from the spirit and scope of embodiment of the present invention technical scheme.
Claims (2)
1. compound recipe micro-glue wound healing conditioning liquid, it is characterised in that its one-tenth is grouped into: benzoflavine 0.5～2.0%, polymyxin
2.0～7.0%, novocain 0.01～0.1%, molecule distillating monoglyceride 1.0～2.0%, polyvinylpyrrolidone 0.5～2.0%,
Ethanol 1.0～10.0%, somatomedin 0.01～0.05%, healing factor 0.2～0.8%, buffer 0.08～3.0%, anticorrosion
Agent 0.02～0.5%, antioxidant 0.01～0.3%, stabilizer 0.01～0.1%, colloid plasticizer 0.2～1.6%, surplus are
Water for injection；
Described somatomedin is epidermal growth factor (EGF), basic fibroblast growth factor (FGF), keratinocyte growth factor
(KGF), any one or a few the combination in transforminggrowthfactor-α (TGF-α) or transforming growth factor-β (TGF-β)；
Described healing factor is any one in hyaluronic acid, glucosamine or allantoin；
Described buffer is any one in Tris-phosphate buffer, buffered with amino acid liquid, GOOD buffer；
Described preservative is sorbic acid and its esters or parabens；
Described antioxidant is superoxide dismutase；
Described stabilizer is D-trehalose；
Described colloid plasticizer is poloxamer188.
2. a kind of compound recipe micro-glue wound healing conditioning liquid as claimed in claim 1, it is characterised in that preparation method is: by sweet for molecular distillation list
Ester is by 1:(10～20) part by weight join in water for injection, be heated to 60～70 DEG C, stirring and dissolving, make hydration single the sweetest
Grease, is cooled to room temperature, adds buffer, stirs 5～10min, add benzoflavine, glue more under 400～500rpm
Rhzomorph, novocain, polyvinylpyrrolidone, ethanol, somatomedin, healing factor, preservative, antioxidant, stable
Agent and surplus water for injection, stirring 20～30min, forms homogeneous mixture, is 0.8% with mass fraction at 600 rpm
Phosphoric acid adjust ph value to 5.5～6.0, be eventually adding colloid plasticizer, under 200～400rpm stir 30～60min, i.e.
Become.
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| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ma Wenxue Inventor after: Liu Xinxin Inventor after: Liu Laijie Inventor before: Liu Ting |
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Effective date of registration: 20160919 Address after: 261799, 98, holy city street, Shouguang, Shandong Applicant after: Ma Wenxue Address before: 710065 Shaanxi Province, Xi'an City Road eight and city building 3 unit 2 and 2503 Applicant before: Liu Ting |
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