CN105213422A - A kind of prevention of obesity and the montmorillonite preparation reducing hyperlipidemia and preparation method thereof - Google Patents
A kind of prevention of obesity and the montmorillonite preparation reducing hyperlipidemia and preparation method thereof Download PDFInfo
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- CN105213422A CN105213422A CN201510571915.2A CN201510571915A CN105213422A CN 105213422 A CN105213422 A CN 105213422A CN 201510571915 A CN201510571915 A CN 201510571915A CN 105213422 A CN105213422 A CN 105213422A
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Abstract
The present invention relates to Chinese medicine mineral field, particularly, the present invention relates to a kind of for prevention of obesity and the montmorillonite preparation reducing hyperlipidemia and preparation method thereof.The preparation of described montmorillonite preparation comprises the following steps and obtains with method: (1) raw ore sorting and pulverizing; (2) slurrying and high speed dispersion; (3) slip dilution and precipitation suspend; (4) purified gel; (5) gel drying and pulverizing.Powdery montmorillonite provided by the invention adds deionized water and fully stirs the gel preparation being configured to desired concn.Said preparation is taken before high oils and fats food of ingesting, its absorption fixed function to oils and fats is utilized to adsorb oil substances excessive in gastrointestinal system, increase the discharge of oil substances, reduce the absorption of intestinal, thus reach prevention of obesity, reduce blood fat and reduce effect of liver lipids accumulation.The invention provides a kind of prevention of obesity and the montmorillonite preparation reducing hyperlipidemia and preparation method thereof.
Description
Technical field
The invention belongs to Chinese medicine mineral field, relate to a kind of prevention of obesity and reduce montmorillonite preparation and preparation method thereof of hyperlipidemia, and as the application of health care medicine.
Background technology
Obesity is a kind of chronic metabolic disease caused by many factors, has become one of important diseases of harm humans health at present, and global prevalence significantly raises, particularly in developing country.Fat with atherosclerosis, hypertension, type 2 diabetes mellitus, blood fat disorder, cancer etc. disease have close relationship, the quality of life of what this was serious affect people.Hyperlipidemia refers to blood fat in blood, as T-CHOL (TC), triglyceride (TG) level is too high or HDL-C (HDL-C) is too low, being a kind of generalized metabolic disease, is also the initiating agent causing cardiovascular and cerebrovascular disease.With fat spreading in the world, the incidence rate of the fatty liver caused by obesity is also increasing year by year.Fatty liver is a kind of pathological changes by fatty overheap in the multifactor hepatocyte caused, and is also a kind of reversibility disease.By adjustment diet and moderate exercise, patient's fatty infiltration of liver phenomenon can reduce and even disappears.
Obesity types of drugs on current world market is various, but what be widely used mainly contains two kinds, a kind of is rely on the sibutramine (Sibutramine) that plays a role of appetite-suppressing, another kind of then be have the medicine orlistat (Orlistat) that suppression intestinal digests and assimilates.This two classes medicine all effectively can suppress the increase of body weight, but usually along with serious toxic and side effects.Therefore, actively the medicine of the treatment obesity that research and development are new has great importance.The factor that occurs of causeing fat is a lot, but the shortage of the excessive and motion of diet, especially absorbing too much oils and fats is one of key factor causeed fat.Uncontrollable due to human food habits, people often eating with the food of a large amount of oils and fats, this bad dietary habit be fat and hyperlipidemia provide inducement, the montmorillonite preparation of a kind of prevention of obesity of the present invention and reduction hyperlipidemia can be taken when absorbing the food containing a large amount of oils and fats, its role is to said preparation and can adsorb oils and fatss a large amount of in food, make it excrete with preparation, reduce intestinal to the absorption of oils and fats, reach the effect of prevention of obesity and hyperlipidemia.
In recent years, various types of purifying montmorillonite mineral are widely used in multiple fields such as medical and health, food, feedstuff and cosmetics.Be that the gastrointestinal tract anti-diarrheal of main component is as montmorillonite powder (dioctahedral smectite) with Montmorillonitum, be confirmed to be OTC medicine, be widely used in treatment diarrhoea or other gastroenteropathy, its diarrhea pharmacological mechanism is generally described as intestinal mucosa protective agent, has fixing, inhibitory action to the toxin of the virus in digestive tract, antibacterial and generation thereof; Have covering power to gastral mucosa, and by be combineding with each other with mucous glycoprotein, reparation, raising mucosal barrier are to the defense function of attack factor.Be that the feedstuff mildew removing agent product of main component is widely used in animal farming industry with Montmorillonitum, main uses is the mycotoxin in adsorption feed or feedstuff, prevention or treatment animal intestinal disease or other relevant disease caused due to mycotoxin.But also do not have Montmorillonitum to adsorb lipid at present, there is prevention of obesity, the report of blood fat reducing and minimizing liver lipids accumulation purposes aspect.
Summary of the invention
The object of this invention is to provide a kind of prevention of obesity and the montmorillonite preparation reducing hyperlipidemia and preparation method thereof, widened the medical usage of Montmorillonitum, can be used as the health care medicine application of prevention of obesity and/or reduction hyperlipidemia.
Another object of the present invention is to provide a kind of method preparing above-mentioned montmorillonite preparation.There is preparation process simple, stable and controllable for quality, the advantage such as cheap.
Another object of the present invention is to provide the oils and fats in the adsorbable gastrointestinal system of above-mentioned montmorillonite preparation, and the discharge increasing oil substances reduces intestinal to the absorption of oils and fats, has prevention of obesity, falls hyperlipidemia and reduces the purposes of liver lipids accumulation.
According to prevention of obesity of the present invention and the method acquisition of montmorillonite preparation by comprising the following steps reducing hyperlipidemia:
(1) raw ore sorting pulverizing and sieving: select pollution-free medicinal canescence montmorillonite mineral, dry, pulverize, sieve, grinding particle size will reach 200-300 order;
(2) slurrying and high speed dispersion: slurrying concentration is advisable with 30-50%, then carry out high speed making beating, make coarse dispersion system:
(3) slip dilution and precipitation suspend: slip diluted concentration is advisable with 3-5%, leave standstill 8-10 hour, get upper strata Montmorillonitum suspension;
(4) purified gel: Montmorillonitum suspension is added appropriate flocculating agent and makes it form colloid, remove portion moisture;
(5) gel drying: with aeration drying or the dry Montmorillonitum colloid of oven drying method, make its water content lower than 10%;
(6) montmorillonite powder body preparation: pulverized by dried Montmorillonitum, grinding particle size will reach more than 300 orders, saves backup again;
(7) preparation of edible montmorillonite preparation: Montmorillonitum powder body adds appropriate amount of deionized water and fully stirs and be configured to desired concn gel preparation.
According to prevention of obesity of the present invention and the montmorillonite preparation preparation method reducing hyperlipidemia, in step 1) in, the medicinal smectite mineral selected are canescence, and grinding particle size will reach 200-300 order.
According to prevention of obesity of the present invention and the montmorillonite preparation preparation method reducing hyperlipidemia, in step 2) in, slurrying concentration is advisable with 30-50%.
According to prevention of obesity of the present invention and the montmorillonite preparation preparation method reducing hyperlipidemia, in step 3) in, slip diluted concentration is advisable with 3-5%, and time of repose is 8-10 hour.
According to prevention of obesity of the present invention and the montmorillonite preparation preparation method reducing hyperlipidemia, in step 5) in, with aeration drying or the dry Montmorillonitum colloid of oven drying method, make its water content lower than 10%.
According to prevention of obesity of the present invention and the montmorillonite preparation preparation method reducing hyperlipidemia, in step 7) in, the appropriate amount of deionized water that adds Montmorillonitum powder body fully stirs and is configured to desired concn gel preparation, and wherein the mass ratio of Montmorillonitum powder body and deionized water is 1: 8-1: 20.Because this Montmorillonitum powder body is obtained by colloid drying, add appropriate amount of deionized water and more easily make gel preparation through fully stirring.
Present invention also offers above-mentioned montmorillonite preparation to apply in prevention of obesity with the medicine of reduction hyperlipidemia, said preparation is taken before high oils and fats food of ingesting, its absorption fixed function to oils and fats is utilized to adsorb oil substances excessive in gastrointestinal system, increase the eliminating of oil substances, reduce the absorption of intestinal, thus reach prevention of obesity, reduce blood fat and reduce effect of liver lipids accumulation.
The present invention has widened the medical usage of Montmorillonitum, also provides a kind of prevention of obesity safely and effectively and the health medicine for the treatment of hyperlipidemia, fatty liver simultaneously.
Accompanying drawing explanation
Fig. 1 is lipid dye Bodipy and micropolariscope coupling, detects the observation image of Montmorillonitum absorb oil in feces.A is normal diet matched group fecal smear, through the detected image of Bodipy dyeing under light field, e is the detected image of the same visual field after 488nm excitation under fluorescence microscope, and i is the composing picture of a and e, and m is the detected image of the same visual field under polarized light; B is that high lipid food matched group fecal smear is through the detected image of Bodipy dyeing under light field, f is the detected image of the same visual field after 488nm excitation under fluorescence microscope, j is the composing picture of b and f, and n is the detected image of the same visual field under polarized light; C is the detected image that high fat+preparation group fecal smear dyes under light field through Bodipy, and g is the detected image of the same visual field after 488nm excitation under fluorescence microscope, and k is the composing picture of c and g, and o is the detected image of the same visual field under polarized light; D is that Montmorillonitum is through the detected image of Bodipy dyeing under light field, h is the detected image of the same visual field after 488nm excitation under fluorescence microscope, l is the composing picture of d and h, and p is the detected image of the same visual field under polarized light, and its Green is oils and fats.
Fig. 2 is lipid dye Bodipy and micropolariscope coupling, detects the observation image of oils and fats in Montmorillonitum absorption gastrointestinal tract.
Detailed description of the invention
Below in conjunction with specific embodiment, explain the present invention further, should be understood that these embodiments are only not used in for illustration of the present invention and limit the scope of the invention.In addition should be understood that those skilled in the art can make various change or amendment to the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after reading content of the present invention.
The montmorillonite preparation preparation method of embodiment 1, prevention of obesity and reduction hyperlipidemia
Select pollution-free medicinal canescence montmorillonite mineral, dry, pulverize at about 100 DEG C, sieve.Grinding particle size will reach 200-300 order.This research selection 200 order-300 mesh sieve hole, is will form aqueous dispersion at short notice based on sample, reaches the object of separation.
Grope according to test, be advisable to Montmorillonitum slurrying concentration with 30-50%, then carry out high speed making beating, make coarse dispersion system, slip diluted concentration is advisable with 3-5%.Through 8-10 hour leave standstill, suspension Montmorillonitum just can with its impurity layering, refining serosity can be obtained after precipitation suspension is separated with sucking filtration.Adding appropriate flocculating agent makes it form colloid, remove portion moisture, and with the dry Montmorillonitum powder of aeration drying, make its water content lower than 10%, pulverized by dried Montmorillonitum again, grinding particle size will reach more than 300 orders, saves backup.
Take a Montmorillonitum to add 9 parts of deionized waters and fully stir and be configured to gel preparation.
Embodiment 2, above-mentioned montmorillonite preparation are to the adsorption of oils and fats in gastrointestinal tract
Experimental technique: 8 week age male CD-1 mice 9, body weight 29 ~ 32 grams, is divided into 3 groups (normal diet matched group, high lipid food matched group and high fat+preparation groups) often to organize 3 at random.Wherein high lipid food formula is 77.75% normal diet+21% fat+1.25% cholesterol, experimental group be high lipid food feed simultaneously every day gavage montmorillonite preparation, dosage is that every kg body weight 1 restrains agent.Normal diet and high lipid food matched group gavage same volume deionized water, continuously process 3 days.
1) each group of mice the 3rd day feces is collected, add appropriate amount of deionized water and make smear, by neutral lipid specific dye Bodipy and micropolariscope coupling---(PBS configures 1 μ g/mLBodipy dye liquor namely to carry out Bodipy dyeing to smear, room temperature lucifuge dyes 15 minutes), by the smear lipid in 488nm observed under fluorescent light feces made, lipid is shown in green; Utilize micropolariscope accurately can locate the position of Montmorillonitum to the direct-detection of Montmorillonite Crystal at the same visual field.Result shows, the experimental group of high lipid food+montmorillonite preparation of feeding mice, and montmorillonite preparation can adsorb the oils and fats in fixing feedstuff, and discharges with feces, the oils and fats that Montmorillonitum adsorbs can be detected, as shown in Figure 1 in stool in mice.
2) collect the 3rd day experimental mice gastrointestinal tract diverse location (Stomach duodenum, jejunum, ileum and colon) content, make smear, by neutral lipid dyestuff Bodipy and micropolariscope coupling, observe Montmorillonitum to the adsorption of oils and fats in gastro-intestinal tract.Result shows, the experimental group of high lipid food+montmorillonite preparation of feeding mice, all can see the oil substances in the fixing gastro-intestinal tract of Montmorillonitum absorption, as shown in Figure 2 at the diverse location of digestive system.
Embodiment 3, above-mentioned montmorillonite preparation are on the impact of Fatty rat
Experimental technique: 8 week age male SD rat 30, body weight 290-310 gram, is divided into 3 groups (normal diet matched group, high lipid food matched group and test group) often to organize 10 at random.Wherein high lipid food formula is 77.75% normal diet+21% fat+1.25% cholesterol, test group be high lipid food feed simultaneously every day gavage montmorillonite preparation, dosage is that every kg body weight 1 restrains agent.Normal diet and high lipid food matched group gavage same volume deionized water, continuously process 25 days.
By detecting the output of each group of rat body weight, each fatty linked groups weight, blood fat, liver lipids and feces lipid.Analyze the effect of this montmorillonite preparation in high fat diet situation in prevention of obesity, hyperlipidemia and fatty liver.
The above-mentioned montmorillonite preparation of table 1 is on the impact of rat body weight and each adipose tissue mass
Above experimental result shows, high lipid food of feeding significantly can increase rat body weight, epididymal adipose tissues, perirenal fat, interior fat can be made obviously to increase, and the above-mentioned montmorillonite preparation of gavage can alleviate the impact of high lipid food on rat, and the body that high lipid food can be prevented to cause is fat.
The above-mentioned montmorillonite preparation of table 2 is on the impact of rat fat
Experimental result shows, and rat blood serum triglyceride, T-CHOL and low-density lipoprotein cholesterol content that this montmorillonite preparation can significantly reduce because high lipid food causes increase, and have the effect of preventing the hyperlipidemia caused by high lipid food.
The impact that the above-mentioned montmorillonite preparation of table 3 is accumulated rat liver weight and liver lipids
Experimental result shows, and this montmorillonite preparation significantly can reduce the rat liver weightening finish because high lipid food causes, and liver lipids (triglyceride, T-CHOL and cholesteryl ester) content increases, and has the effect reducing liver lipids accumulation.
The above-mentioned montmorillonite preparation of table 3 is on the impact of rat feces lipid content
Experimental result shows, and this montmorillonite preparation significantly can increase the outer row of the oils and fats such as triglyceride and T-CHOL in feces, and soluble Montmorillonitum has the mechanism of obesity, blood fat reducing and minimizing liver lipids cumulative utility.
Utilize above-mentioned montmorillonite preparation to the adsorption of lipid, increase body lipid and arrange outward, there is prevention of obesity and reduce the function of hyperlipidemia aspect, be equally applicable to Montmorillonitum or Montmorillonitum adds the application of other adjuvants as prevention of obesity health care medicine.
Claims (3)
1. for prevention of obesity and the montmorillonite preparation preparation method reducing hyperlipidemia, it is characterized in that, described extract is obtained by the method comprised the following steps:
(1) raw ore sorting pulverizing and sieving: select pollution-free medicinal canescence montmorillonite mineral, dry, pulverize, sieve, grinding particle size will reach 200-300 order;
(2) slurrying and high speed dispersion: slurrying concentration is advisable with 30-50%, then carries out high speed making beating, makes coarse dispersion system;
(3) slip dilution and precipitation suspend: slip diluted concentration is advisable with 3-5%, leave standstill 8-10 hour, get upper strata Montmorillonitum suspension;
(4) purified gel: Montmorillonitum suspension is added appropriate flocculating agent and makes it form colloid, remove portion moisture;
(5) gel drying: with aeration drying or the dry Montmorillonitum colloid of oven drying method, make its water content lower than 10%;
(6) montmorillonite powder body preparation: pulverized by dried Montmorillonitum, grinding particle size will reach more than 300 orders, saves backup again;
(7) preparation of edible montmorillonite preparation: Montmorillonitum powder body adds appropriate amount of deionized water and fully stirs and be configured to desired concn gel preparation.
2. a montmorillonite preparation for prevention of obesity and reduction hyperlipidemia, is characterized in that, described preparation is the montmorillonite preparation preparation method that can be used for prevention of obesity and reduce hyperlipidemia according to claim 1.
3. the montmorillonite preparation of prevention of obesity according to claim 1 and reduction hyperlipidemia is used for prevention of obesity, and reduces the application in the medicine of hyperlipidemia.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111281882B (en) * | 2020-02-13 | 2024-04-16 | 青岛惠诺德生物科技有限公司 | Compound preparation for promoting intestinal alkaline phosphatase expression and enhancing activity as well as preparation method, application method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101340979B (en) * | 2006-02-09 | 2010-06-16 | 浙江海力生制药有限公司 | Method for purifying montmorillonite, purified montmorillonite and combination thereof |
-
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101340979B (en) * | 2006-02-09 | 2010-06-16 | 浙江海力生制药有限公司 | Method for purifying montmorillonite, purified montmorillonite and combination thereof |
Non-Patent Citations (3)
| Title |
|---|
| 翟永功等: "药用矿物蒙脱石的红外光谱分析", 《中草药》 * |
| 胡岳华等: "《矿物浮选》", 31 March 2014, 中南大学出版社 * |
| 邱玉超等: "PEG/MMT血脂吸附剂的合成及吸附性能研究", 《2005年全国高分子学术论文报告会》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111281882B (en) * | 2020-02-13 | 2024-04-16 | 青岛惠诺德生物科技有限公司 | Compound preparation for promoting intestinal alkaline phosphatase expression and enhancing activity as well as preparation method, application method and application thereof |
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Application publication date: 20160106 |