CN105213063A - Sd rat continuous intravenous injection equipment - Google Patents
Sd rat continuous intravenous injection equipment Download PDFInfo
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- CN105213063A CN105213063A CN201410290108.9A CN201410290108A CN105213063A CN 105213063 A CN105213063 A CN 105213063A CN 201410290108 A CN201410290108 A CN 201410290108A CN 105213063 A CN105213063 A CN 105213063A
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- intravenous injection
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Abstract
The present invention relates to animal experiment device.SD rat continuous intravenous injection equipment, comprises a syringe, a conduit, and syringe comprises syringe needle, syringe, piston core bar, and syringe needle removably connects conduit; Also comprise an injection power device, injection power device comprises a device for fixing syringe, and syringe is fixed on device for fixing syringe; Injection power device also comprises a piston core bar force aid system, piston core bar force aid system comprises a driving device, driving device connects piston core bar by a drive mechanism, and can advance in syringe or pull out by driven plunger core bar, driving device connects a control device, the length that control device control piston core bar advances or pulls out in syringe.The present invention carries out persistent intravenous injection by syringe to SD rat, and relative to syringe pump, structure is simple, and production cost is low, and injection flexibly.Relative to needle tubing single injection, good bioavailability can be obtained.
Description
Technical field
The present invention relates to experimental article, be specifically related to animal experiment device.
Background technology
SD rat is a strain of rat, Rodentia, Muridae, Genus rattus, belongs to the mutation of wild brown raw rat (Rattusnorvegicus).Originate in the warm area of Central Asia and former Soviet Union part.18 th century later start artificial breeding, the mid-19th century is first for psychologic research, after twentieth century, SD rat is applied to the every field of life science, is especially most widely used in oncology, pharmacology, endocrinology, threpsology.
Summary of the invention
The object of the invention is to, a kind of SD rat continuous intravenous injection equipment is provided, by this equipment, persistent intravenous injection is carried out to SD rat, to obtain good bioavailability.
Technical problem solved by the invention can realize by the following technical solutions:
SD rat continuous intravenous injection equipment, comprise a syringe, for inserting the conduit in SD rat body, described syringe comprises syringe needle, syringe, piston core bar, it is characterized in that, described syringe needle removably connects described conduit;
Also comprise an injection power device, described injection power device comprises a device for fixing syringe, and described syringe is fixed on described device for fixing syringe;
Described injection power device also comprises a piston core bar force aid system, described piston core bar force aid system comprises a driving device, described driving device connects described piston core bar by a drive mechanism, and described piston core bar can be driven to advance in described syringe or pull out, described driving device connects a control device, and described control device controls the length that described piston core bar advances or pulls out in described syringe.
This utility model carries out persistent intravenous injection by syringe to SD rat, and relative to syringe pump, structure is simple, and production cost is low, and injection flexibly.Relative to needle tubing single injection, good bioavailability can be obtained.
During use, described conduit inserts in SD rat body, and the front end of described conduit and the vein UNICOM of SD rat, end stretches out from the omoplate position of SD rat, and is fixed on it SD rat.To facilitate repeatedly or to continue medication.
SD rat continuous intravenous injection equipment also comprises the waistcoat that is applicable to SD rat, and described conduit is fixed on described waistcoat.During use, described waistcoat is through with it SD rat, and waistcoat can fix the position of described conduit further.
SD rat continuous intravenous injection equipment injects the medicine adopted to be concentration be 0.9% normal saline or concentration be the glucose of 5%.
The frequency of injection that described control device controls described syringe be 1,2 or 3 ml/kg/hour.
The injection object of SD rat continuous intravenous injection equipment is at least eight all large SD rats.
Described control device also comprises a pressure transducer, and described pressure transducer is positioned at the piston nose of described piston core bar, and after detection and described tubes connection, the pressure in administration process, as pressure reaches a setting value, described control device is reported to the police.These block and mostly are to be caused by the blood clotting of catheter tip and thrombosis, and as run into this kind of situation in use procedure, small normal pressure usually can be used to discharge these clots, then negative pressure is injected.First can also inject the urokinase of 2500 units, after 20 minutes, carry out drug injection.Urokinase can dissolve and decompose blood clotting.
Described needle tubing fixture comprises a positioning seat, a locating groove, and described needle tubing is fixed on described positioning seat by described locating groove;
Described driving device is motor, described drive mechanism comprises travelling gear, screw rod, slide, guide rod, leader fixed, wherein, described motor drives described screw rod to rotate by travelling gear, one end of described screw rod connects described slide, described slide is arranged on described guide rod, can slides along described guide rod, and described guide rod is arranged between described leader fixed and positioning seat, and the slide draw-in groove of described slide locates the syringe of described syringe.
Described needle tubing to be removably connected described conduit by a universal interface, described universal interface comprises shell, outfan interface, equipment end interface and adapter sleeve, wherein, be connected by described adapter sleeve between the inner port of described outfan interface in described shell and the described equipment end interface inner port in described shell; Described outfan interface can with its axis for rotating shaft freely rotates; Described needle tubing inserts described equipment end interface, and described conduit inserts described outfan interface.To facilitate the connection of conduit and needle tubing.
Described universal interface also comprises following any one or any two devices:
-device presss from both sides, and wherein, described device folder is arranged on the external port of described equipment end interface, and wherein, the external port of described equipment end interface is positioned at the outside of described shell;
-vessel clamp, wherein, described vessel clamp is installed on described outfan interface.Outflow to avoid medicine.
Described barrel sidewall is provided with a medicine-pouring hole, described medicine-pouring hole place is provided with flanging upwards, described medicine-pouring hole is by one and the dismountable plug seal of described medicine-pouring hole, described stopper is provided with a groove, the profile of described groove is consistent with the profile of described flanging, the degree of depth of described groove is not more than the height of described flanging, and when described stopper covers on described medicine-pouring hole, described flanging gos deep in described groove.When medicine changed by needs or when needs carry out repeatedly medication, by opening stopper, opening medicine-pouring hole, carrying out the injection of medicine.Injection is complete, fills in stopper, propelling piston core bar.
Accompanying drawing explanation
Fig. 1 is the primary structure schematic diagram of injection power device of the present invention and syringe;
Fig. 2 is comfortableness muroid holder section separation structure schematic diagram of the present invention;
Fig. 3 is the longitudinal section of stopper of the present invention.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, setting forth the present invention further below in conjunction with concrete diagram.
With reference to Fig. 1, Fig. 2 and Fig. 3, SD rat continuous intravenous injection equipment, comprise a syringe 9, for inserting the conduit in SD rat body, syringe 9 comprises syringe needle, syringe, piston core bar, and syringe needle removably connects conduit; Also comprise an injection power device, injection power device comprises a device for fixing syringe 10, and syringe is fixed on device for fixing syringe 10; Injection power device also comprises a piston core bar force aid system, piston core bar force aid system comprises a driving device, driving device connects piston core bar by a drive mechanism, and can advance in syringe or pull out by driven plunger core bar, driving device connects a control device, the length that control device control piston core bar advances or pulls out in syringe.
Conduit inserts in SD rat body, and the front end of conduit and the vein UNICOM of SD rat, end stretches out from the omoplate position of SD rat, and is fixed on it SD rat.To facilitate multiple dosing.SD rat continuous intravenous injection equipment can also comprise the waistcoat that is applicable to SD rat, and conduit is fixed on waistcoat.During use, waistcoat is through with it SD rat, and waistcoat can the position of A/C further.
SD rat continuous intravenous injection equipment injects the medicine adopted to be concentration be 0.9% normal saline or concentration be the glucose of 5%.
The frequency of injection of SD rat continuous intravenous injection equipment be 1,2 or 3 ml/kg/hour.
The injection object of SD rat continuous intravenous injection equipment is at least eight all large SD rats.
Control device also comprises a pressure transducer, and pressure transducer is positioned at the piston nose of piston core bar, and after detection and tubes connection, the pressure in administration process, as pressure reaches a setting value, control device is reported to the police.Control device can comprise an alarm unit, and control device is externally reported to the police by alarm unit.Alarm unit can audible alarm unit, light warning unit etc.These block and mostly are to be caused by the blood clotting of catheter tip and thrombosis, and as run into this kind of situation in use procedure, small normal pressure usually can be used to discharge these clots, then negative pressure is injected.First can also inject the urokinase of 2500 units, after 20 minutes, carry out drug injection.Urokinase can dissolve and decompose blood clotting.
Needle tubing fixture comprises a positioning seat, a locating groove 7, and needle tubing is fixed on positioning seat by locating groove 7.Driving device is preferably motor 1, drive mechanism comprises travelling gear 2, screw rod 11, slide 5, guide rod 4, leader fixed 3, wherein, motor 1 drives screw rod 11 to rotate by travelling gear 2, one end of screw rod 11 connects slide 5, slide 5 is arranged on guide rod 4, can slides along guide rod 4, and guide rod 4 is arranged between leader fixed 3 and positioning seat, the syringe of slide draw-in groove 6 position syringe 9 of slide 5.Travelling gear 2 is preferably reduction gearing.Motor 1 is preferably motor.Motor 1 can also adopt linear electric motors.Piston core bar force aid system also comprises test rod 8, and wherein, test rod 8 is for detecting the diameter of syringe 9.Control device connects motor 1, carrys out by rotating forward, the reversion number of turns controlling motor 1 length that control piston core bar advances or pulls out in syringe.And then control dosage.
Needle tubing to be removably connected conduit by a universal interface, universal interface comprises shell, outfan interface, equipment end interface and adapter sleeve, wherein, be connected by adapter sleeve between the inner port of outfan interface in shell and the equipment end interface inner port in shell; Outfan interface can with its axis for rotating shaft freely rotates; Needle tubing inserts equipment end interface, and conduit inserts outfan interface.
Universal interface also comprises following any one or any two devices :-device presss from both sides, and wherein, device folder is arranged on the external port of equipment end interface, and wherein, the external port of equipment end interface is positioned at the outside of shell;-vessel clamp, wherein, vessel clamp is installed on outfan interface.
Conduit extends to the far distance port of sheathed catheter by the proximal port of sheathed catheter from the external port of outfan interface, the proximal port of sheathed catheter and the external port of outfan interface lay respectively at the both sides of vessel clamp.
Barrel sidewall can be provided with a medicine-pouring hole, medicine-pouring hole place is provided with flanging upwards, medicine-pouring hole seals with the dismountable stopper 12 of medicine-pouring hole by one, stopper 12 is provided with a groove, the profile of groove is consistent with the profile of flanging, the degree of depth of groove is not more than the height of flanging, and when stopper 12 covers on medicine-pouring hole, flanging gos deep in groove.When medicine changed by needs or when needs carry out repeatedly medication, by opening stopper, opening medicine-pouring hole, carrying out the injection of medicine.Injection is complete, fills in stopper, propelling piston core bar.
SD rat continuous intravenous injection equipment can also comprise a comfortableness muroid holder 14, comfortableness muroid holder 14 comprises one for holding the hollow cavity of experimental mouse, the bore that hollow cavity comprises a front opening is less than the cylinder chamber of conical cavity, in column of the bore of open rearward end, and the open rearward end of conical cavity is connected with cylinder chamber; Comfortableness muroid holder 14 also comprises one for the propulsion plant of shutoff or Promoting Experiment Mus, and at least one side of propulsion plant is an arc-shaped concave, and propulsion plant and hollow cavity removably connect.Hollow cavity one end conical design is in order to adapt with the head of muroid, the arc-shaped concave design of propulsion plant is in order to adapt with the buttocks of muroid, the present invention is by being designed to structure adapt with the external form of muroid, the comfortableness of muroid in experimentation can be improved on the one hand, the activity of muroid can be reduced on the other hand, obtain good injection effect.And dismounting is convenient in each part detachable connection of this device, practical and convenient.
Conical cavity is the conical cavity of an inclination, and the minimum angle in the angle that the conical surface of conical cavity and the side of cylinder chamber are formed is 150 degree, and maximum angle is 175 degree.The external diameter of propulsion plant is not more than the minimum diameter of cylinder chamber; Propulsion plant connects a propellings handle by a connecting rod, the sidewall of cylinder chamber has one and the supporting groove of connecting rod, and propulsion plant is removably connected by connecting rod and groove and hollow cavity.
Comfortableness muroid holder 14 also comprises one for limiting the stopping means of the position of propulsion plant in cylinder chamber, and stopping means is fixed on propelling handle.Stopping means comprises a stopper, and stopper connects a limit switch by drive mechanism, and when limit switch is in spacing state, stopper one props up propelling handle, a shell propping up conical cavity; Limit switch be in not spacing state time, there is gap between stopper and the shell of conical cavity.
The sidewall of cylinder chamber also has one for the Excreta of experimental mouse being discharged the excretion raceway groove of hollow cavity.Excretion raceway groove is the excretion raceway groove of an inclination, and the end height of excretion raceway groove is lower than the front height draining raceway groove, and the front end of excretion raceway groove is the one end near conical cavity.Discharge to facilitate muroid Excreta.The side of conical cavity has a steam vent 13.So that muroid is breathed, thus improve the comfort level of muroid further.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (10)
1.SD rat continuous intravenous injection equipment, comprise a syringe, for inserting the conduit in SD rat body, described syringe comprises syringe needle, syringe, piston core bar, it is characterized in that, described syringe needle removably connects described conduit;
Also comprise an injection power device, described injection power device comprises a device for fixing syringe, and described syringe is fixed on described device for fixing syringe;
Described injection power device also comprises a piston core bar force aid system, described piston core bar force aid system comprises a driving device, described driving device connects described piston core bar by a drive mechanism, and described piston core bar can be driven to advance in described syringe or pull out, described driving device connects a control device, and described control device controls the length that described piston core bar advances or pulls out in described syringe.
2. SD rat continuous intravenous injection equipment according to claim 1, is characterized in that: described conduit inserts in SD rat body, and the front end of described conduit and the vein UNICOM of SD rat, end stretches out from the omoplate position of SD rat, and is fixed on it SD rat.
3. SD rat continuous intravenous injection equipment according to claim 1, is characterized in that: SD rat continuous intravenous injection equipment injects the medicine adopted to be concentration be 0.9% normal saline or concentration be the glucose of 5%.
4. SD rat continuous intravenous injection equipment according to claim 1, is characterized in that: the frequency of injection that described control device controls described syringe be 1,2 or 3 ml/kg/hour.
5. according to the SD rat continuous intravenous injection equipment in claim 1-4 described in any one, it is characterized in that: the injection object of SD rat continuous intravenous injection equipment is at least eight all large SD rats.
6. according to the SD rat continuous intravenous injection equipment in claim 1-4 described in any one, it is characterized in that: described control device also comprises a pressure transducer, described pressure transducer is positioned at the piston nose of described piston core bar, after detection and described tubes connection, pressure in administration process, as pressure reaches a setting value, described control device is reported to the police.
7. SD rat continuous intravenous injection equipment according to claim 6, it is characterized in that: described needle tubing fixture comprises a positioning seat, a locating groove, described needle tubing is fixed on described positioning seat by described locating groove;
Described driving device is motor, described drive mechanism comprises travelling gear, screw rod, slide, guide rod, leader fixed, wherein, described motor drives described screw rod to rotate by travelling gear, one end of described screw rod connects described slide, described slide is arranged on described guide rod, can slides along described guide rod, and described guide rod is arranged between described leader fixed and positioning seat, and the slide draw-in groove of described slide locates the syringe of described syringe.
8. SD rat continuous intravenous injection equipment according to claim 6, it is characterized in that described needle tubing to be removably connected described conduit by a universal interface, described universal interface comprises shell, outfan interface, equipment end interface and adapter sleeve, wherein, be connected by described adapter sleeve between the inner port of described outfan interface in described shell and the described equipment end interface inner port in described shell; Described outfan interface can with its axis for rotating shaft freely rotates; Described needle tubing inserts described equipment end interface, and described conduit inserts described outfan interface.
9. SD rat continuous intravenous injection equipment according to claim 8, is characterized in that: described universal interface also comprises following any one or any two devices:
-device presss from both sides, and wherein, described device folder is arranged on the external port of described equipment end interface, and wherein, the external port of described equipment end interface is positioned at the outside of described shell;
-vessel clamp, wherein, described vessel clamp is installed on described outfan interface.
10. SD rat continuous intravenous injection equipment according to claim 6, it is characterized in that: described barrel sidewall is provided with a medicine-pouring hole, described medicine-pouring hole place is provided with flanging upwards, described medicine-pouring hole is by one and the dismountable plug seal of described medicine-pouring hole, described stopper is provided with a groove, and the profile of described groove is consistent with the profile of described flanging, and the degree of depth of described groove is not more than the height of described flanging, when described stopper covers on described medicine-pouring hole, described flanging gos deep in described groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410290108.9A CN105213063A (en) | 2014-06-24 | 2014-06-24 | Sd rat continuous intravenous injection equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410290108.9A CN105213063A (en) | 2014-06-24 | 2014-06-24 | Sd rat continuous intravenous injection equipment |
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| Publication Number | Publication Date |
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| CN105213063A true CN105213063A (en) | 2016-01-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410290108.9A Pending CN105213063A (en) | 2014-06-24 | 2014-06-24 | Sd rat continuous intravenous injection equipment |
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| CN (1) | CN105213063A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236063A (en) * | 2016-08-16 | 2016-12-21 | 程翌 | A kind of white mice body weight, the rhythm of the heart, the operational approach of body-temperature monitoring device |
| CN107440814A (en) * | 2017-07-31 | 2017-12-08 | 山东中医药大学 | A kind of adjustable precise continuous syringe and its application method |
| CN108355203A (en) * | 2018-04-03 | 2018-08-03 | 佛山市博知盾识科技有限公司 | A kind of injection device and injecting method for automatic intravenous injection |
| CN108744158A (en) * | 2018-04-03 | 2018-11-06 | 佛山市博知盾识科技有限公司 | A kind of automatic intravenous injection system and injecting method |
| CN112206069A (en) * | 2020-10-12 | 2021-01-12 | 北京天悦生科技有限公司 | Continuous injector control method and device and continuous injector |
| CN112891013A (en) * | 2021-01-27 | 2021-06-04 | 中国人民解放军空军军医大学 | Device for injecting medicine into colorectal cavity of small rodent experimental animal |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106236063A (en) * | 2016-08-16 | 2016-12-21 | 程翌 | A kind of white mice body weight, the rhythm of the heart, the operational approach of body-temperature monitoring device |
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| CN108355203B (en) * | 2018-04-03 | 2021-04-23 | 青岛市中医医院(青岛市海慈医院、青岛市康复医学研究所) | Injection device and injection system for automatic intravenous injection |
| CN112206069A (en) * | 2020-10-12 | 2021-01-12 | 北京天悦生科技有限公司 | Continuous injector control method and device and continuous injector |
| CN112891013A (en) * | 2021-01-27 | 2021-06-04 | 中国人民解放军空军军医大学 | Device for injecting medicine into colorectal cavity of small rodent experimental animal |
| CN112891013B (en) * | 2021-01-27 | 2023-08-25 | 中国人民解放军空军军医大学 | Device for injecting medicine into colorectal of small rodent experimental animal |
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Address after: 201203 Shanghai Guo Shou Jing Road, Zhangjiang High Tech Park of Pudong New Area No. 199 experimental building safety evaluation center room 106 Applicant after: Shanghai Yinuosi biotechnology Limited by Share Ltd Applicant after: Shanghai Ruiman Information Technology Co.,Ltd. Address before: 201203 Shanghai Guo Shou Jing Road, Zhangjiang High Tech Park of Pudong New Area No. 199 experimental building safety evaluation center room 106 Applicant before: Shanghai Innostar Bio-tech Co., Ltd. Applicant before: Shanghai Ruiman Information Technology Co.,Ltd. |
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Application publication date: 20160106 |
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