CN105205810B - MR image hippocampus dividing method based on distance field fusion - Google Patents
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Abstract
A kind of MR image hippocampus dividing method based on distance field fusion.Include: (1) to initial MR test image normalized to be split, removes skull and biased field, the MR test image after obtaining normalized;(2) MR training set image and training set label image are registrated to MR test image;(3) the label image after registration is obtained into distance field DF by range conversion;(4) to the point in MR test imageTake image blockAnd it is converted to a column vector;(5) it defines search window and chooses MR dictionary and DF dictionary;(6) it usesLocal linear expresses test sample, seek dictionary weight coefficient vector;(7) test sample is obtainedDF forecast image block vector, and handleIt is converted into image block;(8) step (4)-(7) are repeated, the DF value of each point is obtained;(9) label corresponding to each point of test image is obtained.The method of the present invention can from MR image accurately segmentation object.
Description
Technical field
The present invention relates to medical image analysis technical fields, and in particular to a kind of MR image hippocampus based on distance field fusion
Body dividing method.
Background technique
Hippocampus belongs to the grey matter structure of midbrain, and hippocampus atrophy is Alzheimer's disease, schizophrenia, depression etc.
A kind of pathological manifestations of mental disease can clinically make these mental diseases by the volume and form for analyzing hippocampus
Diagnosis.MRI can provide high-resolution anatomical structure, clear contrast and extensive image sequence, this is facing MRI technique
Bed diagnosis aspect is very popular.Doctor can analyze all brain structures of patient by the brain MR image of patient, thus
Diagnosis is made to disease.The hippocampus of MR brain image is split, is measurement, the morphological analysis of hippocampus volume size
Premise.Since the manual segmentation of hippocampus is very time-consuming, uninteresting, and the segmentation result of different doctor also can difference, sea
Being segmented in clinical application automatically for horse body is particularly important.
Since the volume very little of hippocampus, complex-shaped, obscurity boundary, partial volume effect are obvious in MR image, hippocampus
The automatic segmentation of body is very challenging.
So far, MR image hippocampus dividing method mainly has following two class:
The first kind is the method based on movable contour model (ACM).Such methods are according to image grayscale demographic information
Or image gradient develops to curve (curved surface), final curves (curved surface) converge at object boundary.ACM method is to image
Noise is more sensitive.
Second class is the method based on multichannel chromatogram.Such methods are atlas registration to test image, to the training after deformation
Collect label image, label fusion is realized by some way, obtains final segmentation result.Label fusion do not use to
The shape priors of segmentation object, segmentation precision are limited.
In view of the deficiencies of the prior art, the method for the present invention proposes a kind of MR image hippocampus segmentation based on distance field fusion
Method.
Summary of the invention
The method of the present invention provides a kind of MR image hippocampus dividing method based on distance field fusion, the method for the present invention success
Apply the hippocampus segmentation in MR brain image, the hippocampus in the accurate Ground Split MR image of energy in ground.
Above-mentioned purpose of the invention is realized by following technological means.
A kind of MR image hippocampus dividing method based on distance field fusion, this method are based on two kinds of hypothesis:
I, MR image block and DF image block are located on two non-linearity manifolds, any one MR image block can be where it
Neighbour's sample in the local space of manifold is linearly expressed;
II, under local constraint, the mapping of MR manifold to DF manifold is similar to a differomorphism mapping;
The MR image hippocampus dividing method based on distance field fusion carries out as follows:
(1) to initial MR test image normalized to be split, skull and biased field is removed, normalized is obtained
MR test image afterwards;
(2) by the MR training set image and training set label corresponding with MR training set image in pre-prepd training set
Image registration is to MR test image, so that MR training set image, training set label image and MR test image are on spatial position
Alignment;
(3) range conversion is carried out to the training set label image after step (2) registration, obtains the DF of training set label image
Training set distance field, the value of DF training set distance field corresponding to point x are as follows:
Wherein C indicates the boundary of segmentation object, and B indicates the nearest point of distance x, and B ∈ C, dist (x, B) indicate point x
Euclidean distance between point B;
(4) to the point x in MR test image, an image block x is taken centered on xMR, xMRIt is converted to a column vectorIt is used as the feature of point x, obtains test sampleWherein m representation vectorDimension;
(5) search window is defined centered on point x respectively on training set MR image, training set distance field DF image to choose
Image blockWithConstruct MR dictionary
With DF dictionaryN is the size of dictionary;
(6) based on the assumption that I, with MR dictionary DMRLocal linear indicates MR test sampleDictionary DMRWeight coefficient vectorIt is solved with LAE method, expression is as follows:
Indicate test sampleIn dictionary DMRIn k neighbour;
(7) step (6) resulting dictionary D is usedMRWeight coefficient vectorLinear combination DF dictionary xDFIn sample, obtain
Test sampleDF forecast image block vectorAnd handleIt is converted into image block xDF;Specifically:
Based on the assumption that I, it can obtain:
Based on the assumption that II, it can obtain:
Since f is local linear, therefore:
?It is converted into image block xDF;
(8) each point in MR test image is repeated to operate according to step (4)-(7), obtains the DF training set of each point
The value of distance field;
It is indicated centered on point x, size and x with P (x)DFEqual image block, for any point u in P (x), weight
Are as follows:
The value of the DF training set distance field of point x are as follows:
Indicate the value of the DF training set distance field for the point x that the image block centered on point u is predicted;
(9) to the DF forecast image progress threshold process come is predicted, mark corresponding to each point of test image is obtained
Number, specifically:
The distance field as defined in formula (1) is it is found that the label of point x can be exported by formula (8):
It indicates that the point belongs to segmentation object, and background is indicated marked as 0 marked as 1, hippocampus point is obtained according to segmentation object
Cut image.
Preferably, above-mentioned steps (1) are specifically that MR test image is normalized using gray scale normalization method,
Skull is removed with BET algorithm, removes biased field with N4 algorithm.
Preferably, above-mentioned steps (2) be specifically using DRAMMS software tool by training set MR training set image and
Training set label image is registrated to MR test image.
Preferably, above-mentioned steps (4) are specifically to extract the feature of each point in MR test image, are used as test specimens
This.
Preferably, above-mentioned steps (5) are specifically that local search is used in MR training set image and DF training set distance field
Window constructs MR dictionary and DF dictionary.
Preferably, above-mentioned steps (8) are specifically to handle the DF forecast image block weighted average of overlapping, final to obtain each
The predicted value of the DF training set distance field of point.
The method of the present invention provides a kind of MR image hippocampus dividing method based on distance field fusion, and the method for the present invention can be quasi-
Hippocampus in true Ground Split MR image, can be used for the diagnosis of the mental diseases such as Alzheimer's disease.
Detailed description of the invention
Using attached drawing, the present invention is further illustrated, but the content in attached drawing is not constituted to any limit of the invention
System.
Fig. 1 is the flow diagram of the method for the present invention;
Fig. 2 is the frame diagram of the method for the present invention;
Fig. 3 is the details flow diagram of the method for the present invention;
Fig. 4 is for the method for the present invention with different size of search window to the segmentation result box traction substation of 15 test images;Wherein,
Fig. 4 (a) is the segmentation result box traction substation for right hippocampus, and Fig. 4 (b) is the segmentation result box traction substation for left hippocampus;
Fig. 5 is the segmentation result comparison diagram with label fusion method and distance field fusion method to 15 test images,
In, Fig. 5 (a) is the segmentation result comparison diagram for right hippocampus, and Fig. 5 (b) is the segmentation result comparison diagram for left hippocampus;
Fig. 6 is the coronal-plane of the segmentation result in four test images using distance field fusion method and label fusion method
Schematic diagram, wherein the first row indicates manual segmentation as a result, the second row is the segmentation result using distance field fusion method, third
Row is the segmentation result using label fusion method, and each column indicate a test image.
Specific embodiment
The invention will be further described with the following Examples.
Embodiment 1.
A kind of MR image hippocampus dividing method based on distance field fusion, this method are based on two kinds of hypothesis:
I, MR image block and DF image block are located on two non-linearity manifolds, any one MR image block can be where it
Neighbour's sample in the local space of manifold is linearly expressed;
II, under local constraint, the mapping of MR manifold to DF manifold is similar to a differomorphism mapping.
The MR image hippocampus dividing method based on distance field fusion carries out as follows:
(1) to initial MR test image normalized to be split, skull and biased field is removed, normalized is obtained
MR test image afterwards.Specifically MR test image is normalized using gray scale normalization method, is gone with BET algorithm
Except skull, biased field is removed with N4 algorithm.
(2) by the MR training set image and training set label corresponding with MR training set image in pre-prepd training set
Image registration is to MR test image, so that MR training set image, training set label image and MR test image are on spatial position
Alignment.It is specifically to use DRAMMS software tool by the MR training set image and training set labeled graph in training set in step (2)
As being registrated to MR test image.
(3) range conversion is carried out to the training set label image after step (2) registration, obtains the instruction of training set label image
Practice the value of training set distance field DF corresponding to collection distance field DF, point x are as follows:
Wherein C indicates the boundary of segmentation object, and B indicates the nearest point of distance x, and B ∈ C, dist (x, B) indicate point x
Euclidean distance between point B.
(4) to the point x in MR test image, an image block x is taken centered on xMR, xMRIt is converted to a column vectorIt is used as the feature of point x, wherein m representation vectorDimension.
(5) a search window choosing is defined centered on point x respectively on training set MR image, training set distance field DF image
Take image blockWithConstruct MR dictionary
With DF dictionary
N is the size of dictionary.
(6) based on the assumption that I, with MR dictionary DMRLocal linear indicates MR test sampleDictionary DMRWeight coefficient vectorIt is solved with LAE method, expression is as follows:
Indicate test sampleIn dictionary DMRIn k neighbour.
(7) step (6) resulting dictionary D is usedMRWeight coefficient vectorLinear combination DF dictionary DDFIn sample, obtain
Test sampleDF forecast image block vectorAnd handleIt is converted into image block xDF;Specifically:
Based on the assumption that I, it can obtain:
Based on the assumption that II, it can obtain:
Since f is local linear, therefore:
?It is converted into image block xDF。
(8) each point in MR test image is repeated to operate according to step (4)-(7), obtains the DF value of each point;
It is indicated centered on point x, size and x with P (x)DFEqual image block, for any point u in P (x), weight
Are as follows:
The DF value of point x are as follows:
Indicate the DF value for the point x that the image block centered on point u is predicted.
(9) to the DF forecast image progress threshold process come is predicted, mark corresponding to each point of test image is obtained
Number, specifically:
The distance field as defined in formula (1) is it is found that the label of point x can be exported by formula (8):
It indicates that the point belongs to segmentation object, and background is indicated marked as 0 marked as 1, hippocampus point is obtained according to segmentation object
Cut image.
Preferably, above-mentioned steps (4) are specifically to extract the feature of each point in MR test image, are used as test specimens
This.
Preferably, above-mentioned steps (5) are specifically that local search window is used in MR training set image and DF training set image
Construct MR dictionary and DF dictionary.
Preferably, above-mentioned steps (8) are specifically to handle the DF forecast image block weighted average of overlapping, final to obtain each
The DF predicted value of point.
The method of the present invention provides a kind of MR image hippocampus dividing method based on distance field fusion, and the instruction of priori is utilized
Practice collection MR image, training set distance field DF image, is handled using distance field, the hippocampus in the accurate Ground Split MR image of energy
Body can be used for the diagnosis of the mental diseases such as Alzheimer's disease.
Embodiment 2.
It is according to being tested in database with 35 groups of MR brain datas for including to verify the validity of the method for the present invention
Card.The data of every group of MR brain data include the T1 weighted MR image and corresponding hippocampus label image of same patient,
In select 20 groups of data at random as training set, remaining 15 groups of data is as test set.Test set object is only with it in experiment
MR image does not use the hippocampus label image in corresponding database.
The present invention is based on the MR image hippocampus dividing method of distance field fusion, this method is based on two kinds of hypothesis:
I, MR image block and DF image block are located on two non-linearity manifolds, any one MR image block can be where it
Neighbour's sample in the local space of manifold is linearly expressed;
II, under local constraint, the mapping of MR manifold to DF manifold is similar to a differomorphism mapping.
The MR image hippocampus dividing method based on distance field fusion carries out as follows:
(1) to initial MR test image normalized to be split, skull and biased field is removed, normalized is obtained
MR test image afterwards.Specifically MR test image is normalized using gray scale normalization method, is gone with BET algorithm
Except skull, biased field is removed with N4 algorithm.
(2) by training set MR training set image and training set label image corresponding with MR training set image be registrated to
MR test image, so that MR training set image, training set label image are aligned on spatial position with MR test image.Step
(2) in be specifically using DRAMMS software tool by training set MR training set image and training set label image be registrated to MR
Test image.
(3) range conversion is carried out to the training set label image after step (2) registration, obtains the instruction of training set label image
Practice the value of training set distance field DF corresponding to collection distance field DF, point x are as follows:
Wherein C indicates the boundary of segmentation object, and B indicates the nearest point of distance x, and B ∈ C, dist (x, B) indicate point x
Euclidean distance between point B.
(4) to the point x in MR test image, an image block x is taken centered on xMR, xMRIt is converted to a column vectorIt is used as the feature of point x, wherein m representation vectorDimension.
(5) a search window choosing is defined centered on point x respectively on training set MR image, training set distance field DF image
Take image blockWithConstruct MR dictionary
With DF dictionary
N is the size of dictionary.
(6) based on the assumption that I, with MR dictionary DMRLocal linear indicates MR test sampleDictionary DMRWeight coefficient vectorIt is solved with LAE method, expression is as follows:
Indicate test sampleIn dictionary DMRIn k neighbour.
(7) step (6) resulting dictionary D is usedMRWeight coefficient vectorLinear combination DF dictionary DDFIn sample, obtain
Test sampleDF forecast image block vectorAnd handleIt is converted into image block xDF;Specifically:
Based on the assumption that I, it can obtain:
Based on the assumption that II, it can obtain:
Since f is local linear, therefore:
?It is converted into image block xDFIt can be obtainedThe distance field image block x of predictionDF。
(8) each point in MR test image is repeated to operate according to step (4)-(7), obtains the DF value of each point;
It is indicated centered on point x, size and x with P (x)DFEqual image block, for any point u in P (x), weight
Are as follows:
The DF value of point x are as follows:
Indicate the DF value for the point x that the image block centered on point u is predicted.
(9) to the DF forecast image progress threshold process come is predicted, mark corresponding to each point of test image is obtained
Number, specifically:
The distance field as defined in formula (1) is it is found that the label of point x can be exported by formula (8):
It indicates that the point belongs to segmentation object, and background is indicated marked as 0 marked as 1, hippocampus point is obtained according to segmentation object
Cut image.
By evaluating the accurate of segmentation result with DSC (Dice similarity coefficient, likeness coefficient)
Property, consider two factors: (1) overall performance of this method;(2) compared with label fusion method (abbreviation LF), distance field has
Effect property.
The experimental result of the method for the present invention hereinafter referred to as DFF method is as follows:
Fig. 4 is for the method for the present invention with different size of search window to the segmentation result box traction substation of 15 test images;Wherein,
Fig. 4 (a) is the segmentation result box traction substation for right hippocampus, and Fig. 4 (b) is the segmentation result box traction substation for left hippocampus.
Fig. 5 is the segmentation result comparison diagram with label fusion method and distance field fusion method to 15 test images,
In, Fig. 5 (a) is the segmentation result comparison diagram for right hippocampus, and Fig. 5 (b) is the segmentation result comparison diagram for left hippocampus.
It can be seen that the DSC of the result of DFF segmentation is obviously better than LF method.
Fig. 6 is the coronal-plane of the segmentation result in four test images using distance field fusion method and label fusion method
Schematic diagram, wherein the first row indicates manual segmentation as a result, the second row is the segmentation result using distance field fusion method, third
Row is the segmentation result using label fusion method, and each column indicate a test image.It can be seen that the result ratio of DFF method
The result precision of LF method is high.
The above result shows that can accurate Ground Split MR brain using the MR image hippocampus dividing method merged based on distance field
Hippocampus in portion's image, and then the diagnosis of the mental diseases such as Alzheimer's disease can be used for.Finally it should be noted that more than
Embodiment is merely illustrative of the technical solution of the present invention rather than limiting the scope of the invention, although referring to preferred embodiment
The present invention is explained in detail, those skilled in the art should understand that, technical solution of the present invention can be carried out
Modification or equivalent replacement, without departing from the spirit and scope of technical solution of the present invention.
Claims (5)
1. a kind of MR image hippocampus dividing method based on distance field fusion, it is characterised in that:
The MR image hippocampus dividing method based on distance field fusion is based on two kinds of hypothesis:
I, MR image block and DF image block are located on two non-linearity manifolds, the office of any one MR image block manifold where it
Neighbour's sample in portion space is linearly expressed;
II, under local constraint, the mapping of MR manifold to DF manifold is similar to a differomorphism mapping;
The MR image hippocampus dividing method based on distance field fusion carries out as follows:
(1) to initial MR test image normalized to be split, skull and biased field are removed, after obtaining normalized
MR test image;
(2) by the MR training set image and training set label image corresponding with MR training set image in pre-prepd training set
It is registrated to MR test image, so that MR training set image, training set label image are aligned on spatial position with MR test image;
(3) range conversion is carried out to the training set label image after step (2) registration, obtains the DF training of training set label image
Collect distance field, the value of DF training set distance field corresponding to point x are as follows:
Wherein C indicates the boundary of segmentation object, and B indicates the nearest point of distance x, and B ∈ C, dist (x, B) indicate point x and point B
Between Euclidean distance;
(4) to the point x in MR test image, an image block x is taken centered on xMR, xMRIt is converted to a column vectorIt is used as the feature of point x, obtains test sampleWherein m representation vectorDimension;
(5) search window is defined centered on point x respectively on MR training set image, DF training set distance field image choose figure
As blockWithConstruct MR dictionaryWith DF dictionary N is the size of dictionary;
(6) based on the assumption that I, with MR dictionary DMRLocal linear indicates MR test sampleDictionary DMRWeight coefficient vectorIt is solved with LAE method, expression is as follows:
Indicate test sampleIn dictionary DMRIn k neighbour;
(7) step (6) resulting dictionary D is usedMRWeight coefficient vectorLinear combination DF dictionary DDFIn sample, obtain test specimens
ThisDF forecast image block vectorAnd handleIt is converted into image block xDF;Specifically:
Based on the assumption that I, obtains:
Based on the assumption that II, obtains:
Since f is local linear, therefore:
?It is converted into image block xDF;
(8) each point in MR test image is repeated to operate according to step (4)-(7), obtains the DF training set distance of each point
The predicted value of field;
Specific steps are as follows:
It is indicated centered on point x, size and x with P (x)DFEqual MR image block, for any point u in P (x), weight
Are as follows:
The value of the DF training set distance field of point x are as follows:
Indicate the value of the DF training set distance field for the point x that the DF image block centered on point u is predicted;
(9) to the DF forecast image progress threshold process come is predicted, label corresponding to each point of test image is obtained, is had
Body is:
The distance field as defined in formula (1) knows that the label of point x is exported by formula (8):
It indicates that the point belongs to segmentation object, and background is indicated marked as 0 marked as 1, hippocampus segmentation figure is obtained according to segmentation object
Picture.
2. a kind of MR image hippocampus dividing method based on distance field fusion according to claim 1, it is characterised in that:
The step (1) is specifically that MR test image is normalized using gray scale normalization method, removes cranium with BET algorithm
Bone removes biased field with N4 algorithm.
3. a kind of MR image hippocampus dividing method based on distance field fusion according to claim 2, it is characterised in that:
The step (2) be specifically using DRAMMS software tool by training set MR training set image and training set label image match
Standard arrives MR test image.
4. a kind of MR image hippocampus dividing method based on distance field fusion according to claim 3, it is characterised in that:
The step (5) is specifically to construct MR word using local search window in MR training set image and the middle of DF training set distance field image
Allusion quotation and DF dictionary.
5. a kind of MR image hippocampus dividing method based on distance field fusion according to claim 4, it is characterised in that:
The step (8) is specifically to handle the DF forecast image block weighted average of overlapping, finally obtain the DF training set of each point away from
The predicted value left the theatre.
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