CN105197855A - Buckle-type bottle freeze drying device - Google Patents
Buckle-type bottle freeze drying device Download PDFInfo
- Publication number
- CN105197855A CN105197855A CN201510507890.XA CN201510507890A CN105197855A CN 105197855 A CN105197855 A CN 105197855A CN 201510507890 A CN201510507890 A CN 201510507890A CN 105197855 A CN105197855 A CN 105197855A
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- China
- Prior art keywords
- clamped bottle
- bracket
- hole
- freeze
- diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000004108 freeze drying Methods 0.000 title claims abstract description 41
- 238000003032 molecular docking Methods 0.000 claims description 19
- 238000007906 compression Methods 0.000 claims description 6
- 230000006835 compression Effects 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000741 silica gel Substances 0.000 claims description 4
- 229910002027 silica gel Inorganic materials 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 16
- 230000008569 process Effects 0.000 abstract description 15
- 239000000843 powder Substances 0.000 abstract description 7
- 238000002347 injection Methods 0.000 abstract description 6
- 239000007924 injection Substances 0.000 abstract description 6
- 238000002360 preparation method Methods 0.000 abstract description 6
- 238000012546 transfer Methods 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 208000004141 microcephaly Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000001467 acupuncture Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000009924 canning Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
Landscapes
- Drying Of Solid Materials (AREA)
Abstract
The invention discloses a buckle-type bottle freeze drying device, and belongs to the technical field of the freeze drying auxiliary device. The buckle-type bottle freeze drying device comprises a tray, a buckle-type bottle bracket and a pressure plugging device, wherein the buckle-type bottle bracket is arranged on the tray, the buckle-type bottle bracket is provided with a bracket hole for fixing a buckle-type bottle, and the pressure plugging device comprises a cover plate and a pressure piston pin fixed on the lower surface of the cover plate. By utilizing the buckle-type bottle freeze drying device, the preparation of a buckle-type bottle freeze drying powder injection preparation can be realized; the buckle-type bottle is easy to firmly arrange in the freeze drying process; the heat exchange between the buckle-type bottle and a holding plate is realized, the buckle-type bottle is tightly combined with the buckle-type bottle bracket, and the heat transfer efficiency is high; the pressure plugging process of the buckle-type bottle is realized.
Description
Technical field
The present invention relates to a kind of freeze-drying auxiliary device technical field, specifically a kind of clamped bottle freeze-drying apparatus.
Background technology
The new a kind of new glass tube vial released since clamped bottle is 21st century, due in injection process, liquid can not contact with air, and glass can not be produced as peace cuts open bottle to cut, therefore relative to other glass tube vial, the injection process of clamped bottle is safer, and use procedure is simple, therefore enjoys the favor of world's pharmaceutical industry.Clamped bottle preparation mainly contains two kinds, hydro-acupuncture preparation and powder injection formulation, and clamped bottle hydro-acupuncture preparation obtains mainly through canning means under laminar flow cleaning measure, and clamped bottle powder injection formulation is then obtained by the packing of the aseptic powder injection under laminar flow cleaning measure.Due to the structural uniqueness of clamped bottle (clamped bottle does not have the end), and the clamped bottle of filling liquid needs microcephaly in lower placement, there is following problem and cannot solve in the freeze-drying of current technology to clamped bottle: 1, does not have enough area of contact between clamped bottle with freeze-drying machine partition board or cannot contact at all, cannot carry out interchange of heat in freeze-drying process; 2, clamped bottle freeze-drying process need microcephaly under, existing installation cannot be placed; 3, cannot the clamped bottle after freeze-drying be jumped a queue.Therefore, current clamped bottle can not utilize the direct freeze-drying of freeze dryer, therefore there is no clamped bottle freeze-dried powder.
Summary of the invention
The present invention is directed to clamped bottle set forth above can not directly use freeze dryer to carry out the problem of freeze-drying, and a kind of clamped bottle freeze-drying apparatus of research and design.The technological means that the present invention adopts is as follows:
A kind of clamped bottle freeze-drying apparatus, comprise pallet, clamped bottle bracket and tamponade device, described clamped bottle bracket is arranged on pallet, and described clamped bottle bracket is provided with the bracket hole that diameter coordinates with clamped bottle, and described tamponade device comprises cover plate and is fixed on the tamponade pin of cover plate lower surface.
Further, described tamponade device also comprises plug docking block, described plug docking block is supported on pallet by docking block support portion, and plug docking block is positioned at the top of clamped bottle bracket, and described plug docking block is provided with the tamponade hole corresponding with bracket hole, position.
Further, described tamponade hole stepped hole, comprise superposed diameter holes I and the hole, large footpath I being positioned at bottom, hole, described large footpath I is placed on clamped bottle outside, and the diameter of described diameter holes I equals the internal diameter of clamped bottle.
Further, the side of described diameter holes I is provided with air extractor vent.
Further, described clamped bottle bracket is made up of Heat Conduction Material.
Further, described clamped bottle bracket is made up of silica gel, and the aperture of described bracket hole is less than or equal to the diameter of clamped bottle.
Further, described bracket hole is shoulder hole structure, comprise hole, superposed large footpath II and the diameter holes II being positioned at bottom, the diameter in hole, described large footpath II is less than or equal to the external diameter of clamped bottle bottle, and the diameter of described diameter holes II equals the external diameter of clamped bottle Zha Gai.
Further, the elastic component that cover plate can be made to reset after tamponade is provided with between described cover plate and pallet.
Further, described pallet is provided with spring spool, is provided with spring in described spring spool, and described cover plate is provided with the spring compression pin coordinated with spring spool.
Further, the locating part moving down distance for limiting cover plate and then limit tamponade position is provided with between described pallet and cover plate.
Compared with the prior art, a kind of clamped bottle freeze-drying apparatus of the present invention has the following advantages:
1, clamped bottle freeze-drying apparatus of the present invention is utilized can to realize the preparation of clamped bottle freeze-dried powder;
2, the present invention makes clamped bottle in freeze-drying process, be easy to firm placement;
3, present invention achieves the interchange of heat between clamped bottle and shelf, clamped bottle is combined closely with clamped bottle bracket, and heat transfer efficiency is high;
4, the present invention achieves the tamponade process of clamped bottle simultaneously.
Accompanying drawing explanation
Fig. 1 is the structural representation before embodiment of the present invention tamponade under state.
Fig. 2 is the structural representation after embodiment of the present invention tamponade under state.
Fig. 3 is the plug docking block schematic front view described in the embodiment of the present invention.
Fig. 4 is the A-A cutaway view of Fig. 3.
Fig. 5 is the plug docking block schematic top plan view described in the embodiment of the present invention.
Fig. 6 is the B-B cutaway view of Fig. 5.
Fig. 7 is the clamped bottle carrier structure schematic diagram described in the embodiment of the present invention.
Detailed description of the invention
As shown in figs. 1-7, a kind of clamped bottle freeze-drying apparatus, comprise pallet 6, clamped bottle bracket 9 and tamponade device, described clamped bottle bracket 9 is arranged on pallet 6, described clamped bottle bracket 9 is provided with the bracket hole 15 that diameter coordinates with clamped bottle 8, bracket hole 15 is preferably the arrangement of regular uniform array, and described tamponade device comprises cover plate 1 and is fixed on the tamponade pin 11 of cover plate 1 lower surface.
Described tamponade device also comprises plug docking block 7, described plug docking block 7 is supported on pallet 6 by docking block support portion, the gravity of plug docking block 7 acts on pallet 6 by support portion, but not act on clamped bottle 8, and plug docking block 7 is positioned at the top of clamped bottle bracket 9, described plug docking block 7 is provided with the tamponade hole corresponding with bracket hole 15, position.
As seen in figures 3-6, described tamponade hole stepped hole, comprise superposed diameter holes I 12 and the hole, large footpath I 13 being positioned at bottom, it is outside that hole, described large footpath I 13 is placed on clamped bottle 8, the diameter of described diameter holes I 12 equals the internal diameter of clamped bottle 8, hole I 13, large footpath diameter equals the external diameter of clamped bottle 8, the side of described diameter holes I 12 is provided with air extractor vent 14, the air extractor vent 14 of all diameter holes I 12 is connected, form a net structure, air extractor vent 14 is passages of the distillation of freeze-drying process herb liquid and vacuum degree control.In freeze-drying process, plug 10 is positioned in diameter holes I 12, the top of air extractor vent 14, and tamponade pin 11 inserts diameter holes I 12 and is positioned at the top of plug 10, and clamped bottle 8 is inserted in hole, large footpath I 13.
Described clamped bottle bracket 9 is made up of Heat Conduction Material, while the effect playing fixing clamped bottle 8, as the heat conduction intermediary of interchange of heat between clamped bottle 8 and shelf, realizes the interchange of heat between clamped bottle 8 and shelf.
Described clamped bottle bracket 9 is made up of silica gel, the aperture of described bracket hole 15 is less than or equal to the diameter of clamped bottle 8, preferably be slightly less than the external diameter of clamped bottle 8, clamped bottle 8 can be positioned in bracket hole 15 by the downward diameter of microcephaly, because silica gel has certain elasticity, can be combined with the intimate of clamped bottle 8, avoid the reason such as fabrication error due to clamped bottle 8 cause cannot with the problem of clamped bottle bracket 9 close contact, increase permeability to heat.In freeze-drying process, due to clamped bottle 8 and clamped bottle bracket 9 and equal close contact between clamped bottle bracket 9 and pallet 6, therefore, the liquid in shelf and clamped bottle 8 carries out interchange of heat smoothly by heat transfer.
As shown in Figure 7, described bracket hole 15 is shoulder hole structure, comprise hole, superposed large footpath II 16 and the diameter holes II 17 being positioned at bottom, the diameter in hole, described large footpath II 16 is less than or equal to the external diameter of clamped bottle 8 bottle, and the diameter of described diameter holes II 17 equals the external diameter of clamped bottle 8 Zha Gai.Hole, described large footpath II 16 and diameter holes II 17 junction are the curved surface can fitted with the shoulder of clamped bottle.
The elastic component that cover plate 1 can be made to reset after tamponade is provided with between described cover plate 1 and pallet 6.
Described pallet 6 is provided with multiple spring spool 5, spring 4 is provided with in each spring spool 5, described cover plate 1 is provided with the spring compression pin 2 coordinated with spring spool 5, spring 4 contacts with spring compression pin 2, spring compression pin 2 is welded on cover plate 1, in freeze-drying process, the elastic force of all springs 4 equals the gravity of all annexes on cover plate 1 and cover plate 1, and then plays the effect supporting cover plate 1; In tamponade process, the elastic force of spring 4 is less than gravity and the freeze dryer tamponade power sum of all annexes on cover plate 1 and cover plate 1, make cover plate 1 descending under the effect of tamponade power, until cover plate 1 contacts with limiting stopper to reach specify tamponade position, plug 10 is pressed into assigned address in clamped bottle 8 by tamponade pin 11.
The locating part 3 moving down distance for limiting cover plate 1 and then limit tamponade position is provided with between described pallet 6 and cover plate 1, the locating part 3 that the present embodiment uses is limiting stopper, by adjusting the height of limiting stopper, can control the end position that cover plate 1 is downward in tamponade process, and then restriction plug 10 is pressed into the position in clamped bottle 8.
The working process of the present embodiment is as follows:
Utilize feeding device to be manually or automatically positioned over by the clamped bottle 8 being filled with liquid in the bracket hole 15 on clamped bottle bracket 9, clamped bottle bracket 9 is placed on pallet 6; Plug 10 is positioned in the diameter holes I 12 of plug docking block 7; Plug is docked block 7 to be positioned on pallet 6, guarantee that all clamped bottles 8 insert in hole, large footpath I 13; Be positioned over above device by cover plate 1, guarantee that spring compression pin 2 is positioned in spring spool 5, tamponade pin 11 inserts in diameter holes I 12; This device is positioned on the shelf of freeze dryer, carries out freeze-drying operation; After freeze-drying terminates, in freeze drying box, mix certain cleaned inert gas, make the degree of vacuum in freeze drying box maintain specific scope; The tamponade mechanism of freeze dryer and the tamponade device of the present embodiment is utilized to carry out tamponade to clamped bottle 8; Outlet, obtains the clamped bottle freeze-dried powder that tamponade completes.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (10)
1. a clamped bottle freeze-drying apparatus, it is characterized in that: comprise pallet, clamped bottle bracket and tamponade device, described clamped bottle bracket is arranged on pallet, described clamped bottle bracket is provided with the bracket hole that diameter coordinates with clamped bottle, and described tamponade device comprises cover plate and is fixed on the tamponade pin of cover plate lower surface.
2. clamped bottle freeze-drying apparatus according to claim 1, it is characterized in that: described tamponade device also comprises plug docking block, described plug docking block is supported on pallet by docking block support portion, and plug docking block is positioned at the top of clamped bottle bracket, described plug docking block is provided with the tamponade hole corresponding with bracket hole, position.
3. clamped bottle freeze-drying apparatus according to claim 2, it is characterized in that: described tamponade hole is shoulder hole structure, comprise superposed diameter holes I and the hole, large footpath I being positioned at bottom, hole, described large footpath I is placed on clamped bottle outside, and the diameter of described diameter holes I equals the internal diameter of clamped bottle.
4. clamped bottle freeze-drying apparatus according to claim 3, is characterized in that: the side of described diameter holes I is provided with air extractor vent.
5. clamped bottle freeze-drying apparatus according to claim 1, is characterized in that: described clamped bottle bracket is made up of Heat Conduction Material.
6. clamped bottle freeze-drying apparatus according to claim 5, is characterized in that: described clamped bottle bracket is made up of silica gel, and the aperture of described bracket hole is less than or equal to the diameter of clamped bottle.
7. clamped bottle freeze-drying apparatus according to claim 6, it is characterized in that: described bracket hole is shoulder hole structure, comprise hole, superposed large footpath II and the diameter holes II being positioned at bottom, the diameter in hole, described large footpath II is less than or equal to the external diameter of clamped bottle bottle, and the diameter of described diameter holes II equals the external diameter of clamped bottle Zha Gai.
8. clamped bottle freeze-drying apparatus according to claim 1, is characterized in that: be provided with the elastic component that cover plate can be made to reset after tamponade between described cover plate and pallet.
9. clamped bottle freeze-drying apparatus according to claim 8, is characterized in that: described pallet is provided with spring spool, be provided with spring in described spring spool, described cover plate is provided with the spring compression pin coordinated with spring spool.
10. clamped bottle freeze-drying apparatus according to claim 9, is characterized in that: be provided with the locating part moving down distance for limiting cover plate and then limit tamponade position between described pallet and cover plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510507890.XA CN105197855A (en) | 2015-08-18 | 2015-08-18 | Buckle-type bottle freeze drying device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510507890.XA CN105197855A (en) | 2015-08-18 | 2015-08-18 | Buckle-type bottle freeze drying device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105197855A true CN105197855A (en) | 2015-12-30 |
Family
ID=54945896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510507890.XA Pending CN105197855A (en) | 2015-08-18 | 2015-08-18 | Buckle-type bottle freeze drying device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105197855A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07124228A (en) * | 1993-11-05 | 1995-05-16 | Shibuya Kogyo Co Ltd | Stopper driver |
| US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
| CN2663393Y (en) * | 2003-11-25 | 2004-12-15 | 高献亭 | Single rod corking machine |
| CN2756565Y (en) * | 2004-12-15 | 2006-02-08 | 上海远东制药机械总厂 | Bottle stopper placing structure for freeze-drying machine |
| CN101411671A (en) * | 2008-10-16 | 2009-04-22 | 应城市恒天药业包装有限公司 | Novel medicinal bottle stopper for lyophilized powder formulation |
| CN202175543U (en) * | 2011-08-12 | 2012-03-28 | 云南省腾冲制药厂 | Tamponade bottle batch tamponade device |
-
2015
- 2015-08-18 CN CN201510507890.XA patent/CN105197855A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07124228A (en) * | 1993-11-05 | 1995-05-16 | Shibuya Kogyo Co Ltd | Stopper driver |
| US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
| CN2663393Y (en) * | 2003-11-25 | 2004-12-15 | 高献亭 | Single rod corking machine |
| CN2756565Y (en) * | 2004-12-15 | 2006-02-08 | 上海远东制药机械总厂 | Bottle stopper placing structure for freeze-drying machine |
| CN101411671A (en) * | 2008-10-16 | 2009-04-22 | 应城市恒天药业包装有限公司 | Novel medicinal bottle stopper for lyophilized powder formulation |
| CN202175543U (en) * | 2011-08-12 | 2012-03-28 | 云南省腾冲制药厂 | Tamponade bottle batch tamponade device |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160205 Address after: 116000 Liaoning, Dalian, Jinzhou New District, northeast street, No. seven, -5-10, 10 Applicant after: Song Zhantao Address before: 116000 Liaoning, Dalian, Jinzhou New District, northeast street, No. seven, -5-10, 10 Applicant before: DALIAN TIANREY SCIENCE AND TECHNOLOGY CO., LTD. |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151230 |