CN105193947B - A kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide - Google Patents
A kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide Download PDFInfo
- Publication number
- CN105193947B CN105193947B CN201510593894.4A CN201510593894A CN105193947B CN 105193947 B CN105193947 B CN 105193947B CN 201510593894 A CN201510593894 A CN 201510593894A CN 105193947 B CN105193947 B CN 105193947B
- Authority
- CN
- China
- Prior art keywords
- nitrofurazone
- auristilla
- andrographolide
- added
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide.Nitrofurazone auristilla is the clinically used local external use's antibacterials of domestic hospitals ear-nose-throat department.Nitrofurazone auristilla obtained by traditional preparation methods has the disadvantage that stability is poor, and during storage and clinical use, color is easily deepened, and brown color crystallization is easily precipitated in nitrofurazone under the conditions of winter low temperature；Heating and long agitation are needed when preparation；The content of nitrofurazone with crystallization content number have different degrees of decline, make its clinical efficacy reduce and be not available.The nitrofurazone auristilla of method preparation disclosed by the invention, technique have obtained great optimization.Phenomena such as products obtained therefrom passes through 24 months reserved sample observings, has no crystallization and muddiness, there is very strong stability.Content through UV-VIS spectrophotometry measurement nitrofurazone, content is without significant change during storage, and content loss percentage is less than 1%.
Description
The application be application No. is: 2013103058705, the applying date are as follows: 2013-07-22, title are as follows: " using ultrasound
The method that wave-microwave quickly prepares nitrofurazone auristilla preparation ", Chinese invention patent divisional application.
Technical field
The present invention relates to field of pharmaceutical preparations, specifically nitrofurazone auristilla preparation method.
Background technique
Nitrofurazone auristilla is the clinically used local external use's antibacterials of domestic hospitals ear-nose-throat department, treats middle ear
Scorching and otitis externa is curative for effect, and clinical application is extensive.
Currently, nitrofurazone auristilla is usually voluntarily prepared by each hospital, main component is the nitrofurazone of recipe quantity, second
Pure and mild glycerine (Liu Huiyi, the preparation of nitrofurazone auristilla and assay, " Journal of Chinese Hospital Pharmacy "), appearance is
The clear and bright oily liquids of yellow, mildly bitter flavor.Its main function is the early stage for interfering bacterium glycometabolism, leads to bacterial metabolism disorder
And it is dead.Its antimicrobial spectrum is wider, has antibacterial action to a variety of Grain-positives and negative bacterium, also has effect to anaerobic bacteria, to green pus
Bacillus and Diplococcus pneumopniae active force are weak, have drug resistance to Pseudomonas and Proteus, and to fungi, mould is invalid, but
It is still effective to bacterium infection caused by mould.The bacteriocidal concentration of its sensitive bacteria is 13-20 μ g/ml, and Mlc is 5-10 μ g/
ml。
Currently, " Chinese Hospitals preparation specification " the preparation method is as follows: accurately weighed nitrofurazone 2g and 250ml ethyl alcohol are mixed
It closes uniformly, then is added slowly in appropriate glycerine, be sufficiently stirred and make it dissolve, heat when necessary, it is cold after it is completely dissolved
To room temperature, then add glycerine to full dose 1000ml, mix to get.
Traditional preparation methods prepare nitrofurazone auristilla, and there is some shortcomings: firstly, since mentioning by agitating device
For limited shearing force, mixing time is too long, and the preparation amount for preparing 500ml or more is more difficult, it is more difficult to prepare 1000ml with
On preparation amount.Secondly, entire solution system is spacious to be put in a series of process for preparation such as stirring, easily cause drug by extraneous dirty
Dye.Again, the meeting that light, dirt in air and oxygen molecule, metal ion generate in process of production generates drug quality certain
Influence, such as so that it is darkened, accelerate crystallization generate etc..To sum up, existing nitrofurazone auristilla stability is poor, Chang
Just occur the phenomenon that discoloration, muddy or precipitation crystallization during storage, especially prepare in winter and long-term store is easier to that crystallization is precipitated.
To reduce curative effect, therefore current preparation method can only be short-term to store i.e. with i.e. use.
Summary of the invention
The purpose of the invention is to provide that a kind of stability is good, be easy to mass production, the nitrofurazone of long-term preservation drop
Ear fluid preparation is suitable for medical institutions, pharmacy corporation is mass produced.
Purpose is created to realize the present invention the technical solution adopted is that such, and a kind of utilization ultrasonic-microwave is quick
The method for preparing nitrofurazone auristilla preparation, comprising the following steps:
1) it weighs recipe quantity nitrofurazone to be added in glass container, recipe quantity ethyl alcohol is added into the glass container.This
In step, it is generally the case that nitrofurazone and ethyl alcohol press portion rate as (2:250)；(gram) is with volume (milliliter) ratio by weight
(1:125), the prescription recorded such as certain pharmacopeia are as follows: nitrofurazone 2g, ethyl alcohol 250ml.Preferably, this step 1) in glass hold
Device be with the glass jar of plug or other can open/closed container, after containing nitrofurazone and ethyl alcohol, the glass
Container can seal.Further, before containing nitrofurazone and ethyl alcohol, the brown glass container and its plug are by disinfection
Processing.
2) add water into the rinse bath of ultrasonic cleaning machine, the glass container for filling nitrofurazone and ethyl alcohol is put into clearly
In washing trough.In this step, the ultrasonic cleaning machine of medical field or household is can be used in the ultrasonic cleaning machine, has an appearance
Receive the rinse bath of cleaning solution (present invention can use water), the friendship frequency signal that supersonic generator is issued is converted by energy converter
It is traveled in the cleaning solution at friendship frequency mechanical oscillation.
3) starting step 2) described in ultrasonic cleaning machine, ultrasonic dissolution assisting at least 2 minutes.I.e. to the glass in the rinse bath
Container applies the ultrasonic wave of certain frequency, the purpose is to dissolve the nitrofurazone in the glass container in ethanol, and
Influence its performance.Meanwhile the beaker for filling glycerine being put into micro-wave oven, extremely by the glycerine microwave heating in the beaker
70 DEG C~75 DEG C.In the present invention, the amount of the glycerine in the beaker is recipe quantity, and the ethyl alcohol and glycerine are by portion rate
(1:3), the prescription recorded such as certain pharmacopeia are as follows: nitrofurazone 2g, ethyl alcohol 250ml, glycerine about 750ml, total amount 1000ml.It is worth
Illustrate, due to having hydroxyl in glycerol molecule structure, it can quickly be heated using micro-wave oven, be reached
Fabulous technical effect.
4) water in the rinse bath of the ultrasonic cleaning machine is heated up to 60 DEG C, i.e., so that the glass container is in 60 DEG C
In water-bath.It will be added in the glass container for filling nitrofurazone and ethyl alcohol, be uniformly mixed by the glycerine of step 3) processing
Nitrofurazone auristilla is obtained afterwards.Preferably, the ultrasound is clear during glycerine is added to glass jar by this step
It washes device not close, i.e., the described glass container is still in step 3) in identical environment, only when glycerine is added, is needed
Open the plug of the glass container.Further, this step is slowly added into glycerine in glass jar, i.e., using dropwise addition
Mode, after nitrofurazone all dissolution it is clear and bright after, the glycerine in beaker is all added in glass jar, shake glass jar
Afterwards, plug is covered, is kept in dark place.
Preferably, above-mentioned steps 1~4 carry out under the conditions of being protected from light.
The present invention has the advantage that first, easy to operate, without many lengthy and tedious processes such as electromagnetic agitation, reduces
With extraneous contact, keep products obtained therefrom cleaner, and preparation time is short, process；Second, significantly improve nitrofurazone
Stability in prescription stablizes resulting product property during long time stored, almost without content decline, knot
Situations such as crystalline substance, discoloration；Third, improves uniformity of dosage units, improves shelf index, thus enhance clinical application safety and
Validity.
Detailed description of the invention
The device of the invention can be further illustrated by the nonlimiting examples that attached drawing provides.
Fig. 1 is the nitrofurazone auristilla ultraviolet detection map prepared using the method for the present invention；
Fig. 2 is the nitrofurazone auristilla ultraviolet detection map prepared using conventional method；
Fig. 3 is the nitrofurazone auristilla that is prepared using the method for the present invention in the microcosmic (400 under microscope of first month
×) property stability observation result；
Fig. 4 is microcosmic (in microscope under 400 ×) property of the nitrofurazone auristilla in first month of conventional method preparation
Shape stability observing result；
It is microcosmic (400 under microscope at six month that Fig. 5 is the nitrofurazone auristilla that is prepared using the method for the present invention
×) property stability observation result；
Fig. 6 is microcosmic (in microscope under 400 ×) property of the nitrofurazone auristilla of conventional method preparation at six month
Shape stability observing result；
It is microcosmic (under microscope at the 12nd month that Fig. 7 is the nitrofurazone auristilla that is prepared using the method for the present invention
400 ×) property stability observes result；
Fig. 8 is microcosmic (in microscope under 400 ×) of the nitrofurazone auristilla of conventional method preparation at the 12nd month
Property stability observes result；
Fig. 9 is that the nitrofurazone auristilla of conventional method preparation is microcosmic (400 under microscope at the 24th month
×) property stability observation result；
Figure 10 be conventional method preparation nitrofurazone auristilla the 24th month be precipitated crystallization under the microscope
The observation image of (400 ×).
Specific embodiment
The invention is described further below with reference to embodiment, but should not be construed the above-mentioned master of the invention
Topic range is only limitted to following embodiments.Without departing from the technical idea of the present inventions, common according to this field
Technological know-how and customary means make various replacements and change, should all include in the protection scope of the invention.
Embodiment 1
Composition:
| Composition | Dosage |
| Nitrofurazone | 2g |
| Ethyl alcohol | 250ml |
| Glycerine | About 750ml |
| Full dose | 1000ml |
Nitrofurazone 2g is weighed, it is accurately weighed, it is transferred in the glass jar of tool plug.250ml is added to the glass jar
Ethyl alcohol is uniformly mixed and is placed in the rinse bath of ultrasonic cleaning machine, ultrasonic dissolution assisting 2min, that is, opens the ultrasonic cleaning machine (ultrasound
Power 500W, frequency 40KHz).Meanwhile the 1000ml beaker for filling glycerine being put into micro-wave oven, with high fire, (microwave is exported
Power 700W, microwave frequency 2450Hz) heating 70s so that its temperature is reached 70 DEG C~75 DEG C.Under ultrasound condition, slowly by heat third
Triol is added in glass jar, continues ultrasound 6min, and during which bath temperature is arranged at 60 DEG C, and to nitrofurazone, all dissolution is clear and bright
Afterwards, the time of ultrasound is recorded.Add glycerine to full dose 1000ml, to get nitrofurazone auristilla preparation after shaking uniformly.Make
To be preferred, the present embodiment above process carries out under the conditions of being protected from light.
The prescription prepares 1000ml, total time-consuming 12min (wherein ultrasound 8min) by the method for the present invention, and products obtained therefrom is clear and bright
Yellow oily liquid.
Embodiment 2
Composition:
| Composition | Dosage |
| Nitrofurazone | 20g |
| Ethyl alcohol | 2500ml |
| Glycerine | About 7500ml |
| Full dose | 10000ml |
Preparation method: weighing nitrofurazone 20g, accurately weighed, is transferred in the glass jar of tool plug, and it is mixed that 2500ml ethyl alcohol is added
Conjunction is uniformly placed in ultrasonic cleaning machine, ultrasonic dissolution assisting 5min.Period will successively fill the 1000ml beaker of recipe quantity glycerine
Be put into micro-wave oven, with high fiery (microwave output power 700W, microwave frequency 2450Hz) heating 70s make its temperature reach 70 DEG C-
75℃.Under ultrasound condition, slowly hot glycerine is added in glass jar, continues ultrasound 40min, during which bath temperature setting exists
60 DEG C, after all dissolution is clear and bright after nitrofurazone, record the time of ultrasound.Add glycerine to full dose 10000ml (i.e. in total plus
Enter about 7500ml glycerine), suitably stir evenly to get.The above process carries out under the conditions of being protected from light.
The prescription prepares 10000ml, total time-consuming 53min (wherein ultrasound 45min) by the method for the present invention, and products obtained therefrom is clear
Bright yellow oily liquid.
Embodiment 3
As in preferred embodiment step 1) of the invention, weighing after glass container is added in recipe quantity nitrofurazone, to described
Compound is added in glass container.Compound described in the present embodiment is the mixture of swap buffers, andrographolide, ratio such as following table
It is described.
Compound nitrofurazone auristilla has many advantages, such as what common nitrofurazone auristilla did not had, moreover, by
Subsequent experimental of the invention proves that stability, the curative effect of preparation obtained by the addition of compound are substantially better than the preparation of conventional method.
The present embodiment discloses a kind of composition, i.e. compound nitrofurazone auristilla, this prescription in addition to main ingredient nitrofurazone,
Also add the Chinese medicine compound prescriptions ingredient such as swap buffers and andrographolide, these ingredients to improve nitrofurazone auristilla curative effect,
Prevention recurrence etc. has definite meaning.
| Composition | Dosage |
| Nitrofurazone | 20g |
| Swap buffers | 150g |
| Andrographolide | 100g |
| Ethyl alcohol | 2500ml |
| Glycerine | About 7460ml |
| Full dose | 10000ml |
Preparation method: nitrofurazone about 20g, dual coptis powder 150g and andrographolide 100g (the present embodiment are weighed
The dual coptis powder and andrographolide of use are commercially available, wherein shuanghuanglian powder injection is mentioned by honeysuckle, radix scutellariae, Fructus Forsythiae
Pure Chinese medicinal preparation used for intravenous injection made from object is taken, andrographolide is white crystals, is to be with dry Folium Andrographis medicinal material
Raw material, the solid obtained using water-ethanol as Extraction solvent).
Nitrofurazone, dual coptis powder and andrographolide are transferred in the glass jar of tool plug, 2500ml ethyl alcohol is added
It is uniformly mixed and is placed in ultrasonic cleaning machine, ultrasonic dissolution assisting 10min.Period will successively fill the 1000ml of recipe quantity glycerine
Beaker is put into micro-wave oven, so that its temperature is reached 70 with high fiery (microwave output power 700W, microwave frequency 2450Hz) heating 70s
℃-75℃.Under ultrasound condition, slowly hot glycerine is added in glass jar, continues ultrasound 45min, during which bath temperature is set
It sets at 60 DEG C, after all dissolution is clear and bright after nitrofurazone, swap buffers and andrographolide, records the time of ultrasound.Add the third three
Alcohol to full dose 10000ml, suitably stir evenly to get.The above process carries out under the conditions of being protected from light.
The prescription prepares 10000ml, total time-consuming 60min (wherein ultrasound 55min) by the method for the present invention, and products obtained therefrom is clear
Bright pale yellowish oil liquid takes its part labeled as sample 1, so as to subsequent analysis.
It takes part by product made from 2 disclosed method of embodiment, is labeled as sample 2.
Nitrofurazone auristilla is prepared by the preparation method of " Chinese Hospitals preparation specification " and the formula of the present embodiment, is marked
For sample 3.
Compound nitrofurazone auristilla is prepared by the preparation method of " Chinese Hospitals preparation specification " and the formula of the present embodiment,
Nitrofurazone that will be single in " Chinese Hospitals preparation specification " is substituted for nitrofurazone, dual coptis powder and andrographolide
The mixture of composition.Gained compound nitrofurazone auristilla is labeled as sample 4.
1) stable content is investigated:
Nitrofurazone assay when the selection progress of sample 1~4 first month, 12 months and 24 months, knot
Fruit is as follows:
The above results show that sample 1 and 2 has similar stability.And sample 3 and 4 is difficult to long-term preservation.Especially pair
In compound preparation, use conventional methods after preparing because its stability is poor, it is difficult to play the effect of compound.
Meanwhile above-mentioned experiment shows no matter this method prepares nitrofurazone auristilla or compound nitrofurazone auristilla,
Preferable stability can be obtained.
2) macroscopical character study on the stability:
It is the clear and bright oily liquids of yellow at the beginning of preparation by sample 1 and sample 4 prepared by the method for the present invention, no naked eyes
Visible muddy and crystallization.But the color of sample 4 is yellow oily liquid, is deeper than the color of sample 1, and have a small amount of precipitating.
Have a large amount of macroscopic crystallization after storing December, in sample 4, and sample 1 has no crystallization and muddiness
Phenomena such as.
3) Toxicity Analysis
Clinical observation on the therapeutic effect:
Patient 1, male, the age 10, acute suppurative otitis media, and otalgia is suppurated, using the furans west of the method for the present invention preparation
Woods auristilla (i.e. sample 3), ear bath, 2~3 drip every time, and 3 times a day, two days later, otalgia, symptom of suppurating are alleviated, and continue to make
With three days, recovery from illness.
Patient 2, female, the age 43, chronic otitis media, otalgia, tinnitus, prolonged throughout the year with a small amount of yellow sticky discharge
It is not cured (symptom is serious compared with patient 1).The compound nitrofurazone auristilla (i.e. sample 4) prepared using the method for the present invention, ear bath, often
Secondary 2~3 drop, 3 times a day, after three days, all symptoms are alleviated, and continue to use one week, fully recover.
Animal experiment:
Using rat acute otitis media suppurative model, observation is used after the method for the present invention compound nitrofurazone auristilla
Situation.
Model production method: by rat anesthesia, streptococcus pneumonia bacteria suspension is then injected into tympanum, wherein 1~4 day is
Acute infection period, eardrum is congested, there is a large amount of fester secretion, and infection in 5~7 days is faded, and 7 days are later infection later period, disease
Shape disappears substantially, and minority still has a small amount of secretion.
The variation of eardrum and tympanum is observed after medication: after modeling successfully, using compound nitrofurazone in acute infection period
Auristilla (experimental group uses sample 4), and as a control group using the physiological saline of equivalent.It has been observed that control group is acute
Infection phase eardrum is seriously congested, there is the faint yellow fester secretion to yellow in tympanum；And experimental group hyperemia situation obviously compared with
Gently, fester secretory volume is less.Congested and fester disappears control group substantially after 14 days；And experimental group medication two days later, it is above-mentioned
Situation improves completely.
Pass through above-mentioned test, it was demonstrated that the addition of swap buffers can prevent tympanitis or ear canal inflammation especially chronic otitis media or
The effect of ear canal inflammation recurrence can enhance therapeutic effect with nitrofurazone combination；Andrographolide have antibacterium and dermatophyte,
The addition of the pharmacological effects such as antiviral, antiallergic action, andrographolide has association to the antibacterial effect of nitrofurazone auristilla
Same-action, the two and nitrofurazone use in conjunction, can enhance the effect to tympanitis especially chronic sympton, and the stabilization of drug
Property is preferable.
Embodiment 4:
Three batches of nitrofurazone auristilla preparations are prepared respectively by method disclosed in embodiment 1 and formula, are respectively labeled as
Sample 1, sample 2 and sample 3.
As a comparison, nitrofurazone auristilla 10000ml is prepared by the formula of embodiment 2 using conventional method, it is total to consume
When 390min, products obtained therefrom is yellow oily liquid, be labeled as sample 4.
1) assay:
Precision measures the nitrofurazone auristilla 5.00ml in sample 1, is placed in 50ml measuring bottle, is diluted with water to scale,
It shakes up.Precision measures dilution 2.00ml, is placed in 50ml measuring bottle, is diluted with water to scale, shake up, according to UV-vis spectroscopy
Photometry measures absorbance at 375nm wavelength to get ultraviolet detection map shown in attached drawing 1.
Precision measures the nitrofurazone auristilla 5.00ml in sample 4, is placed in 50ml measuring bottle, is diluted with water to scale,
It shakes up.Precision measures dilution 2.00ml, is placed in 50ml measuring bottle, is diluted with water to scale, shake up, according to UV-vis spectroscopy
Photometry measures absorbance at 375nm wavelength to get ultraviolet detection map shown in attached drawing 2.
2) stable content is investigated:
Nitrofurazone assay when the selection progress of sample 1~4 first month, 12 months and 24 months, knot
Fruit is as follows:
3) macroscopical character study on the stability:
The sample 1~3 prepared by the method for the present invention is yellow at the beginning of preparation with sample 4 obtained by conventional method
Clear and bright oily liquids, the muddiness being visible by naked eyes and crystallization.But the color of sample 4 be yellow oily liquid, be slightly deeper than sample 1~
3 color, the reason of causing this phenomenon may be that traditional preparation methods are easily produced by illumination, oxygen molecule and metal ion catalysis
Raw catabolite leads to color burn.
After storing December, have a large amount of macroscopic crystallization in sample 4, and sample 1~3 have no crystallization with it is muddy
Phenomena such as turbid.I.e. product stability obtained by microwave-ultrasonic method is apparently higher than obtained by traditional preparation methods, and color is slightly shallowly and more
Clarification.
4) microcosmic property stability observation:
Choosing sample 1 and sample 4 respectively is representative, and (400 ×) carry out first month, the 6th month, the under microscope
Microcosmic property stability observation at 12 months and the 24th month.
Referring to attached drawing 3~10 (Fig. 3 be 1 first month of sample observation as a result, Fig. 4 be 4 first month of sample observation as a result,
Fig. 5 is observation in sample 1 six month as a result, Fig. 6 is observation in sample 4 six month as a result, Fig. 7 is to see for sample 1 the 12nd month
It examines as a result, Fig. 8 is observation in sample 4 the 12nd month as a result, Fig. 9 is observation in sample 1 the 24th month as a result, Figure 10 is sample
4 the 24th months observation results):
It can be observed from Fig. 3,4, two kinds of preparation methods are showed no crystallization at the beginning of preparation.
It can be observed from Fig. 5,6, after storing six months under the same conditions, though being visible by naked eyes crystallization, amplifying
400 × under the conditions of, the existing a small amount of crystallization of traditional preparation methods is precipitated, and microwave-ultrasonic method no matter visually observes or microscope
Under be showed no crystallization be precipitated.
It can be observed from Fig. 7,8, after storing 12 months under the same conditions, the existing a large amount of naked eyes of traditional preparation methods can
The yellow crystal seen is precipitated.And the crystallization that microwave-ultrasonic method is visible by naked eyes, and amplify 400 × under the conditions of also there are no knot
It is brilliant.
It can be observed from Fig. 9,10, after storing 24 months under the same conditions, the crystallization of traditional preparation methods precipitation
Quantity further increases, and volume further increases, and crystallizes color and gradually become yellowish-brown.And microwave-ultrasonic method is still without naked eyes
Visible crystallization, and amplify 400 × under the conditions of had not yet to see crystallization.
According to the relevant regulations of " Chinese Hospitals preparation specification ", the validity period of nitrofurazone auristilla is 12 months, and
Nitrofurazone auristilla prepared by the present invention is up to interim appearance and the content of being always maintained at of 24 months reserved sample observings
Stablize, the relevant regulations in " Chinese Pharmacopoeia " in relation to external preparation are fully achieved.The present invention improves nitrofurazone auristilla
Shelf index, makes it possible the industrialized production of the medicine.
Claims (6)
1. a kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide, which comprises the following steps:
1) it weighs recipe quantity nitrofurazone to be added in glass container, recipe quantity ethyl alcohol is added into the glass container；To described
Compound is added in glass container；The compound is the mixture of swap buffers, andrographolide；Nitrofurazone and ethyl alcohol g by weight
It is 1: 125 with volume mL ratio；The weight ratio of nitrofurazone and swap buffers, andrographolide is 2: 15: 10；
2) add water into the rinse bath of ultrasonic cleaning machine, the glass container for filling nitrofurazone and ethyl alcohol is put into rinse bath
In；
3) starting step 2) described in ultrasonic cleaning machine, ultrasonic dissolution assisting at least 2 minutes；Meanwhile the beaker for filling glycerine being put
Enter in micro-wave oven, by the glycerine microwave heating in the beaker to 70 DEG C~75 DEG C；
4) water in the rinse bath of the ultrasonic cleaning machine is heated up to 60 DEG C, will be added to by the glycerine of step 3) processing
In the glass container for filling nitrofurazone and ethyl alcohol, that is, obtain nitrofurazone auristilla preparation.
2. a kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide according to claim 1, feature
Be: in step 1), the glass container is the brown glass tank with plug.
3. a kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide according to claim 2, feature
Be: in step 4), during glycerine is added to tool plug brown glass tank, the ultrasonic cleaning machine is not closed.
4. a kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide according to claim 3, feature
It is: in step 4), glycerine is slowly added into brown glass tank, after all dissolution is clear and bright after nitrofurazone, by beaker
In remaining glycerine be all added in brown glass tank, stirring or shaking so that solution is covered plug after mixing, be protected from light
It saves.
5. a kind of Chinese patent drug auristilla system containing swap buffers and andrographolide according to any one of claims 1 to 4
Agent, it is characterised in that: in step 1), after weighing recipe quantity nitrofurazone addition glass container, be added into the glass container
Compound.
6. a kind of Chinese patent drug auristilla system containing swap buffers and andrographolide according to any one of claims 1 to 4
Agent, it is characterised in that: step 1~4 carry out under the conditions of being protected from light.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510593894.4A CN105193947B (en) | 2013-07-22 | 2013-07-22 | A kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310305870.5A CN103417470B (en) | 2013-07-22 | 2013-07-22 | Ultrasonic-microwave is utilized to prepare the method for nitrofural [Dan preparation fast |
| CN201510593894.4A CN105193947B (en) | 2013-07-22 | 2013-07-22 | A kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310305870.5A Division CN103417470B (en) | 2013-07-22 | 2013-07-22 | Ultrasonic-microwave is utilized to prepare the method for nitrofural [Dan preparation fast |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105193947A CN105193947A (en) | 2015-12-30 |
| CN105193947B true CN105193947B (en) | 2018-12-11 |
Family
ID=49643217
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510593864.3A Active CN105078881B (en) | 2013-07-22 | 2013-07-22 | It is a kind of to use special frequency channel ultrasonic wave and the microwave combined method for preparing nitrofurazone auristilla |
| CN201510593894.4A Active CN105193947B (en) | 2013-07-22 | 2013-07-22 | A kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide |
| CN201510593873.2A Active CN105078885B (en) | 2013-07-22 | 2013-07-22 | A kind of nitrofurazone auristilla preparation for being capable of long-time stable preservation |
| CN201310305870.5A Active CN103417470B (en) | 2013-07-22 | 2013-07-22 | Ultrasonic-microwave is utilized to prepare the method for nitrofural [Dan preparation fast |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510593864.3A Active CN105078881B (en) | 2013-07-22 | 2013-07-22 | It is a kind of to use special frequency channel ultrasonic wave and the microwave combined method for preparing nitrofurazone auristilla |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510593873.2A Active CN105078885B (en) | 2013-07-22 | 2013-07-22 | A kind of nitrofurazone auristilla preparation for being capable of long-time stable preservation |
| CN201310305870.5A Active CN103417470B (en) | 2013-07-22 | 2013-07-22 | Ultrasonic-microwave is utilized to prepare the method for nitrofural [Dan preparation fast |
Country Status (1)
| Country | Link |
|---|---|
| CN (4) | CN105078881B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156862A (en) * | 2013-03-28 | 2013-06-19 | 孙国栋 | Compound voriconazole eardrops and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130053875A (en) * | 2011-11-16 | 2013-05-24 | 포항공과대학교 산학협력단 | Metal nanoparticle-incorporated red blood cell and contrast agent containing the same |
-
2013
- 2013-07-22 CN CN201510593864.3A patent/CN105078881B/en active Active
- 2013-07-22 CN CN201510593894.4A patent/CN105193947B/en active Active
- 2013-07-22 CN CN201510593873.2A patent/CN105078885B/en active Active
- 2013-07-22 CN CN201310305870.5A patent/CN103417470B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156862A (en) * | 2013-03-28 | 2013-06-19 | 孙国栋 | Compound voriconazole eardrops and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 刘辉义.呋喃西林滴耳液的配制与含量测定.《中国医院药学杂志》.1987,第7卷(第10期),458-459. * |
| 宝安县人民医院五官科.穿心莲滴剂治疗化脓性中耳炎55例疗效观察.《新医学》.1971,13-14. * |
| 寿张轩等.硼酸滴耳液的制备方法改进.《中国药房》.2008,第19卷(第25期),1967-1968. * |
| 霍俊英等.双黄连滴耳剂治疗急、慢性化脓性中耳炎.《现代中西医结合杂志》.1997,第6卷(第03期),367-368. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105078881A (en) | 2015-11-25 |
| CN105078881B (en) | 2018-04-10 |
| CN105078885B (en) | 2017-12-12 |
| CN105078885A (en) | 2015-11-25 |
| CN103417470B (en) | 2015-10-21 |
| CN103417470A (en) | 2013-12-04 |
| CN105193947A (en) | 2015-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103168886B (en) | Chinese herb tea with effects of relieving summer heat and clearing damp and preparation method of tea | |
| CN104323986A (en) | Phloroglucinol injection and preparation method thereof | |
| CN113662936A (en) | Application of EGCG in preparation of medicine for regulating intestinal flora | |
| CN101890030A (en) | Composite capable of preventing bacteria, viruses, oxidation and pigment deposition | |
| CN104352566A (en) | Oil-in-water compound chlortetracycline nanoemulsion | |
| CN105998286B (en) | Daidaidai flower extract microemulsion preparation and preparation method thereof | |
| CN105193947B (en) | A kind of Chinese patent drug auristilla preparation containing swap buffers and andrographolide | |
| CN112773733A (en) | Acne-removing composition and preparation method of emulsion thereof | |
| CN102872158B (en) | External drug combination for curing eczema and preparation method thereof | |
| CN103040849A (en) | Tannic acid preparation for treating burn, bedsore and diaper dermatitis and preparation method thereof | |
| CN104856946A (en) | High-safety dexamethasone sodium phosphate injection and preparation technology thereof | |
| CN104027408A (en) | Oil-in-water type compound apramycin nano-emulsion | |
| CN101983649A (en) | Method for preparing traditional Chinese medicine tincture for curing leucoderma | |
| CN105030979B (en) | A kind of anti-osteoma compound ointment preparation and preparation method thereof | |
| CN105012404A (en) | Eye drop for treating xerophthalmus and preparation method of eye drop | |
| CN101569612A (en) | Lyophilized clindamycin phosphate powder needle reagent | |
| CN114191484B (en) | Miao medicine tooth fixing prescription for treating periodontitis and preparation method thereof | |
| CN107998222A (en) | Beautyberry extract, its preparation method and application | |
| CN103961376A (en) | Pharmaceutical composition for controlling skin scars and preparation method thereof | |
| CN104274404A (en) | Compound doxycycline antibacterial medicine | |
| RU2497514C1 (en) | Immunomodulator | |
| CN102772542B (en) | Compound buccal tablet used for preventing oral diseases | |
| CN104274532A (en) | Compound griseofulvin antibacterial medicine | |
| CN108096108B (en) | Composition for inhibiting bacteria, eliminating acne and relieving itching and preparation method and application thereof | |
| CN102210725A (en) | Application of hypericum japonicum thunb general flavone in preparing medicament for treating hepatic fibrosis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |