CN105193836A - Method of supplementing nucleotide and preparation for external use - Google Patents
Method of supplementing nucleotide and preparation for external use Download PDFInfo
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- CN105193836A CN105193836A CN201510575358.1A CN201510575358A CN105193836A CN 105193836 A CN105193836 A CN 105193836A CN 201510575358 A CN201510575358 A CN 201510575358A CN 105193836 A CN105193836 A CN 105193836A
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Abstract
The invention discloses a method of supplementing nucleotide and a preparation for external use. Curative or healthcare components are added into a drug for external use or a healthcare product to promote the healthy growth of cells such as soft tissues and bones and the like of animals or human bodies, and the nucleotide or a substance capable of being converted into the nucleotide is also added. The nucleotide is absorbed by the animals or human bodies by virtue of skin to promote a replication process of the cell genes of the soft tissues and the bones and the like of the animals or the human bodies. By utilizing the function of triggering immunity reaction of the skin, desoxyribonucleic acid also can be converted into the nucleotide. By adopting the method of supplementing the nucleotide and the preparation for external use, a novel way which is low in cost, high in efficiency and flexible to operate is provided for absorbing the nucleotide from an external source.
Description
Technical field
The present invention relates to the external curing and healthcare field that promote animal body or the growth of the cell health such as human body soft tissue, skeleton.
Background technology
Animal body and human body cell are by gene replication and express realization propagation.The genetic stew of animal body and human body is DNA (deoxyribonucleic acid) (DNA), and the basic function unit of DNA (deoxyribonucleic acid) (DNA) is nucleotide.The nucleotide of animal body and human body has two sources: 1, synthesis in body, 2, external source is supplemented, external source is supplemented and is mainly referred to that orally ingestible contains medicine or the food of DNA (deoxyribonucleic acid) (DNA), absorb after digestive system digestion is for nucleotide, but the efficiency that digestive system absorbs nucleotide is very low.When synthesizing ribonucleotide in body can not meet the needs of whole body or local body, be necessary that the channel widening supplementary nucleotide also improves the efficiency of supplementing.
Deoxyribonucleotide (DNA) is extensively present in exogenous organisms, but due to DNA (deoxyribonucleic acid) (DNA) be macromolecular substances, animal body and human body skin can not directly external picked-ups.But, the www.xinhuanet.com on 02 27th, 2012 report: " the international research group that the mechanism such as Japanese keio university participates in finds in zoopery; the hair follicle of growth chaeta is when perceiving outside stimulus or inflammation risk; can convene immunocyte and make it be distributed in epidermis and go; triggering immune reacts ... research worker is pasted on the ear of experimental mouse, tear adhesive tape to stimulate its ear's hair follicle, and by the trend of immunocyte in its skin of special microscopic examination.Found that, after about 1 hour, hair follicle place has just assembled large quantities of immunocyte.Wherein, foreign body can be absorbed, then also move to epiderm skin through hair follicle to the arborescent cell of other immunocytes sign object of attack.Research group is reported on up-to-date first phase " nature---immunology (NatureImmunology) " magazine online edition, they find after studying hair follicle tissue, have the specific hair follicle cell of part to generate the chemotactic factor ' can convening ' immunocyte.The mankind also have identical phenomenon with it ... this time research then shows, outside stimulus can be considered as the sign of foreign body intrusion by the hair follicle of growth chaeta, thus triggering immune reaction." this is that skin indirect external picked-up DNA (deoxyribonucleic acid) (DNA) provides new foundation.
There is lysosome immunocyte inside, includes multiple hydrolytic enzyme.Immunocyte has the function of engulfing foreign cell, decomposing desoxyribose nucleic acid (DNA) in foreign cell, and self meeting disintegrate after engulfing 5 ~ 25 foreign cells, the lysosome also together disintegrate of its inside, multiple hydrolytic enzyme in lysosome is released, other cell near solubilized, and DNA (deoxyribonucleic acid) (DNA) is wherein converted into nucleotide.The skin of animal body and human body can absorb small-molecule substance, and the molecular mass of nucleotide only has hundreds of dalton, is in the scope of skin-absorbable.
In addition, the sexual cell Main Ingredients and Appearance of animals and humans is DNA (deoxyribonucleic acid) (DNA); In external preparation, add organic solvent can improve skin absorptance.
Summary of the invention
The object of the invention is to utilize skin follicle can the function of triggering immune reaction, the macromole DNA (deoxyribonucleic acid) (DNA) in external preparation is decomposed into micromolecule nucleotide, thus is directly absorbed by skin; Or utilize the condition that nucleic acid molecule quality is little, produce nucleotide in advance, then make it be absorbed by the skin.
To achieve these goals, present invention uses following technical scheme:
External supplements the method for nucleotide, elements addition or health care composition in topical drug or health product, to promote animal body or human body soft tissue, the isocellular healthy growth of skeleton, wherein, also add nucleotide or the material of nucleotide can be converted into, nucleotide is absorbed by the passive object or person body of skin, to promote the duplicating process of animal body or the cytogene such as human body soft tissue, skeleton.
External supplements the preparation of nucleotide, containing the external curing composition or the health care composition that promote animal body or the growth of the cell health such as human body soft tissue, skeleton, wherein, also containing nucleotide or the material that can be converted into nucleotide.
Further illustrate as of the present invention, above-described external supplements in the method for nucleotide, what described nucleotide contained four kinds of bases---adenine, guanine, cytosine, thymus pyrimidine---is wherein a kind of, and copy required base ratio according to animal body or the cytogene such as human body soft tissue, skeleton, determine the quantity of the nucleotide containing different base, to improve the efficiency that nucleotide is utilized.
Further illustrate as of the present invention, above-described external supplements in the preparation of nucleotide, and the material of described be converted into nucleotide is the sexual cell of animals or humans.
Further illustrate as of the present invention, above-described external supplements in the method for nucleotide, the material of described be converted into nucleotide is DNA (deoxyribonucleic acid), and by physics or medicine irritation skin, skin follicle triggering immune is reacted, utilize the function of the engulfing of immunocyte, decomposition function and disintegration itself, release lysosomal enzyme, the DNA (deoxyribonucleic acid) be applied on skin is converted into nucleotide.
Further illustrate as of the present invention, above-described external supplements in the preparation of nucleotide, also containing chafe, the medicine that makes skin follicle triggering immune react, or chafe of arranging in pairs or groups, apparatus that skin follicle triggering immune is reacted.
Further illustrate as of the present invention, above-described external supplements in the method for nucleotide, also adds organic solvent to improve skin absorptance.
Further illustrate as of the present invention, above-described external supplements in the preparation of nucleotide, also containing the organic solvent being improved skin absorptance.
Compared with prior art, the beneficial effect that possesses of the present invention:
For the external source of animal body and human body nucleotide supplements the new channel providing skin and absorb, both nucleotide can be produced in advance, absorb through skin again, also nucleotide can not be produced in advance, and directly at skin surface, DNA (deoxyribonucleic acid) (DNA) is converted into nucleotide, then directly absorb.Meanwhile, animals or humans sexual cell is easy to get easy-to-use, and the operation of chafe is also simpler.Therefore, the present invention is the new channel that animal body and human body external source supplement that nucleotide provides a low cost, high efficiency, flexible operation.
Accompanying drawing explanation
Fig. 1 is that nucleotide of the present invention absorbs schematic diagram.
Fig. 2 of the present inventionly utilizes hair follicle immunoreation schematic diagram.
Fig. 3 of the present inventionly utilizes immunocyte phagocytic function schematic diagram.
Fig. 4 of the present inventionly utilizes immunocyte disintegrate, release lysosomal enzyme functional schematic.
Reference numeral: 1-nucleotide, 2-deoxyribosyl nucleic acid, 3-skin, 4-cytogene, 5-stimulates, 6-immunocyte, and 7-engulfs, and 8-decomposes, 9-disintegrate, 10-lysosomal enzyme.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is further described.
Embodiment 1:
External supplements the method for nucleotide, elements addition or health care composition in topical drug or health product, to promote animal body or human body soft tissue, the isocellular healthy growth of skeleton, wherein, also add nucleotide 1 or the material 2 of nucleotide can be converted into, nucleotide 1 is absorbed by the passive object or person body of skin 3, to promote the duplicating process of animal body or the cytogene such as human body soft tissue, skeleton 4.
Embodiment 2:
External supplements the preparation of nucleotide, containing the external curing composition or the health care composition that promote animal body or the growth of the cell health such as human body soft tissue, skeleton, wherein, also containing nucleotide 1 or the material 2 that can be converted into nucleotide.
Embodiment 3:
(as shown in Figure 1) external supplements the method for nucleotide, elements addition or health care composition in topical drug or health product, to promote animal body or human body soft tissue, the isocellular healthy growth of skeleton, wherein, also add nucleotide 1 or the material 2 of nucleotide can be converted into, nucleotide 1 is absorbed by the passive object or person body of skin 3, to promote the duplicating process of animal body or the cytogene such as human body soft tissue, skeleton 4.
The wherein one of described nucleotide 1 containing four kinds of bases---adenine, guanine, cytosine, thymus pyrimidine---, and copy required base ratio according to animal body or the cytogene such as human body soft tissue, skeleton 4, determine the quantity of the nucleotide 1 containing different base, to improve the efficiency that nucleotide 1 is utilized.
Embodiment 4:
External supplements the preparation of nucleotide, containing the external curing composition or the health care composition that promote animal body or the growth of the cell health such as human body soft tissue, skeleton, wherein, also containing nucleotide 1 or the material 2 that can be converted into nucleotide.
The material 2 of described be converted into nucleotide is the sexual cell of animals or humans.
Embodiment 5:
(as shown in Figure 1) external supplements the method for nucleotide, elements addition or health care composition in topical drug or health product, to promote animal body or human body soft tissue, the isocellular healthy growth of skeleton, wherein, also add nucleotide 1 or the material 2 of nucleotide can be converted into, nucleotide 1 is absorbed by the passive object or person body of skin 3, to promote the duplicating process of animal body or the cytogene such as human body soft tissue, skeleton 4.
(as shown in Figure 2,3, 4) material 2 of the be converted into nucleotide described in is DNA (deoxyribonucleic acid), and by physics or medicine irritation 5 skin 3, skin 3 hair follicle 11 triggering immune is reacted, utilize the engulfing 7, decompose 8 functions and disintegration itself 9 of immunocyte 6, the function of release lysosomal enzyme 10, the DNA (deoxyribonucleic acid) be applied on skin 3 is converted into nucleotide 1.
Embodiment 6:
External supplements the preparation of nucleotide, containing the external curing composition or the health care composition that promote animal body or the growth of the cell health such as human body soft tissue, skeleton, wherein, also containing nucleotide 1 or the material 2 that can be converted into nucleotide.
Also containing stimulation 5 skin 3, the medicine that makes skin 3 hair follicle 11 triggering immune react, or stimulation 5 skin 3 of arranging in pairs or groups, apparatus that skin 3 hair follicle 11 triggering immune is reacted.
Embodiment 7:
(as shown in Figure 1) external supplements the method for nucleotide, elements addition or health care composition in topical drug or health product, to promote animal body or human body soft tissue, the isocellular healthy growth of skeleton, wherein, also add nucleotide 1 or the material 2 of nucleotide can be converted into, nucleotide 1 is absorbed by the passive object or person body of skin 3, to promote the duplicating process of animal body or the cytogene such as human body soft tissue, skeleton 4.
The wherein one of described nucleotide 1 containing four kinds of bases---adenine, guanine, cytosine, thymus pyrimidine---, and copy required base ratio according to animal body or the cytogene such as human body soft tissue, skeleton 4, determine the quantity of the nucleotide 1 containing different base, to improve the efficiency that nucleotide 1 is utilized.
(as shown in Figure 2,3, 4) material 2 of the be converted into nucleotide described in is DNA (deoxyribonucleic acid), and by physics or medicine irritation 5 skin 3, skin 3 hair follicle 11 triggering immune is reacted, utilize the engulfing 7, decompose 8 functions and disintegration itself 9 of immunocyte 6, the function of release lysosomal enzyme 10, the DNA (deoxyribonucleic acid) be applied on skin 3 is converted into nucleotide 1.
Also add organic solvent to improve skin 3 absorbance.
Embodiment 8:
External supplements the preparation of nucleotide, containing the external curing composition or the health care composition that promote animal body or the growth of the cell health such as human body soft tissue, skeleton, wherein, also containing nucleotide 1 or the material 2 that can be converted into nucleotide.
The material 2 of described be converted into nucleotide is the sexual cell of animals or humans.
Also containing stimulation 5 skin 3, the medicine that makes skin 3 hair follicle 11 triggering immune react, or stimulation 5 skin 3 of arranging in pairs or groups, apparatus that skin 3 hair follicle 11 triggering immune is reacted.
Also containing the organic solvent being improved skin 3 absorbance.
Claims (8)
1. external supplements the method for nucleotide, elements addition or health care composition in topical drug or health product, to promote animal body or human body soft tissue, the isocellular healthy growth of skeleton, it is characterized in that, also add nucleotide (1) or the material (2) of nucleotide can be converted into, nucleotide (1) is absorbed by the passive object or person body of skin (3), to promote the duplicating process of animal body or the cytogene such as human body soft tissue, skeleton (4).
2. external supplements the preparation of nucleotide, containing the external curing composition or the health care composition that promote animal body or the growth of the cell health such as human body soft tissue, skeleton, it is characterized in that, also containing nucleotide (1) or the material (2) that can be converted into nucleotide.
3. external according to claim 1 supplements the method for nucleotide, it is characterized in that, described nucleotide (1) is---adenine, guanine, cytosine, thymus pyrimidine---wherein a kind of containing four kinds of bases, and copy required base ratio according to animal body or the cytogene such as human body soft tissue, skeleton (4), determine the quantity of the nucleotide (1) containing different base, to improve the efficiency that nucleotide (1) is utilized.
4. external according to claim 2 supplements the preparation of nucleotide, it is characterized in that, the sexual cell that the material (2) of described be converted into nucleotide is animals or humans.
5. external according to claim 1 supplements the method for nucleotide, it is characterized in that, the material (2) of described be converted into nucleotide is DNA (deoxyribonucleic acid), and by physics or medicine irritation (5) skin (3), skin (3) hair follicle (11) hair follicle (11) triggering immune is reacted, utilize the engulfing of immunocyte (6) (7), decompose (8) function and disintegration itself (9), the function of release lysosomal enzyme (10), the DNA (deoxyribonucleic acid) be applied on skin (3) is converted into nucleotide (1).
6. external according to claim 2 supplements the preparation of nucleotide, it is characterized in that, also containing the medicine stimulating (5) skin (3), make skin (3) hair follicle (11) triggering immune react, or the apparatus that collocation stimulates (5) skin (3), skin (3) hair follicle (11) triggering immune is reacted.
7. the external according to claim 1,3,5 supplements the method for nucleotide, it is characterized in that, also adds organic solvent to improve skin (3) absorbance.
8. the external according to claim 2,4,6 supplements the preparation of nucleotide, it is characterized in that, also containing the organic solvent being improved skin (3) absorbance.
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| CN201510575358.1A CN105193836A (en) | 2015-09-11 | 2015-09-11 | Method of supplementing nucleotide and preparation for external use |
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| CN201510575358.1A CN105193836A (en) | 2015-09-11 | 2015-09-11 | Method of supplementing nucleotide and preparation for external use |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1267519A (en) * | 1999-03-19 | 2000-09-27 | 浅间化成株式会社 | Immune regulator, immune regulator food and immune regulator fodder |
| CN101426370A (en) * | 2004-06-15 | 2009-05-06 | 艾德拉药物股份有限公司 | Immunostimulatory oligonucleotide multimers |
| CN101897977A (en) * | 2010-07-29 | 2010-12-01 | 浙江大学 | Application of ionic type cyclodextrin derivative in preparation of medicine preparation for iontophoresis transdermal administration |
| CN102517292A (en) * | 2005-11-25 | 2012-06-27 | 科勒制药股份公司 | Immunostimulatory oligoribonucleotides |
| CN103169972A (en) * | 2011-12-23 | 2013-06-26 | 北京大学第三医院 | New application of statin compound as topical medicine for preventing and curing osteoporotic fracture |
| WO2015085043A1 (en) * | 2013-12-04 | 2015-06-11 | EP Technologies LLC | Transdermal delivery of dna vaccines using non-thermal plasma |
-
2015
- 2015-09-11 CN CN201510575358.1A patent/CN105193836A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1267519A (en) * | 1999-03-19 | 2000-09-27 | 浅间化成株式会社 | Immune regulator, immune regulator food and immune regulator fodder |
| CN101426370A (en) * | 2004-06-15 | 2009-05-06 | 艾德拉药物股份有限公司 | Immunostimulatory oligonucleotide multimers |
| CN102517292A (en) * | 2005-11-25 | 2012-06-27 | 科勒制药股份公司 | Immunostimulatory oligoribonucleotides |
| CN101897977A (en) * | 2010-07-29 | 2010-12-01 | 浙江大学 | Application of ionic type cyclodextrin derivative in preparation of medicine preparation for iontophoresis transdermal administration |
| CN103169972A (en) * | 2011-12-23 | 2013-06-26 | 北京大学第三医院 | New application of statin compound as topical medicine for preventing and curing osteoporotic fracture |
| WO2015085043A1 (en) * | 2013-12-04 | 2015-06-11 | EP Technologies LLC | Transdermal delivery of dna vaccines using non-thermal plasma |
Non-Patent Citations (3)
| Title |
|---|
| 蓝建中: "毛囊也会触发免疫反应", 《医药前沿》 * |
| 赵建等: "外源核苷酸的生物学特性及在乳代品中的作用 ", 《中国乳品工业》 * |
| 赵建等: "外源核苷酸的生物学特性及在乳代品中的作用", 《中国乳品工业》 * |
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Application publication date: 20151230 |