CN105168820A - Chinese herba preparation for nasopharynx cancer radiosensitization and preparation method thereof - Google Patents
Chinese herba preparation for nasopharynx cancer radiosensitization and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herba preparation for nasopharynx cancer radiosensitization and a preparation method thereof. The Chinese herba preparation is prepared from, by weight, 14-16 parts of radices trichosanthis, 14-16 parts of astragalus membranaceus, 9-15 parts of bighead atractylodes rhizome, 9-15 parts of rhizoma anemarrhenae, 7-10 parts of radices sileris, 7-10 parts of radix rehmanniae, 7-10 parts of radix pseudostellariae, 7-10 parts of rehmannia glutinosa, 7-10 parts of angelica sinensis, 5-8 parts of radix scrophulariae and 4-7 parts of Chinese herbaceous peony. According to the Chinese herba preparation for nasopharynx cancer radiosensitization and the preparation method thereof, pure natural Chinese herbal medicine is selected to be prepared into the Chinese herba preparation through combination of the modern production technology according to a traditional Chinese medicine theory composition, and the Chinese herba preparation has the effects of invigorating qi and strengthening the spleen, nourishing blood and enriching yin, clearing away heat and toxic materials, dispelling wind and relieving pains; the Chinese herba preparation is effective in treatment, safe and nontoxic, thereby being safe and effective radiosensitization traditional Chinese medicine; the curative effect of nasopharynx cancer radiotherapy can be improved, and side reactions are reduced.
Description
Technical field
The invention belongs to Chinese medicine complex preparation technical field, be specifically related to Chinese medicine preparation of a kind of nasopharyngeal carcinoma radiation sensitization and preparation method thereof.
Background technology
Nasopharyngeal carcinoma is China and Southeast Asian countries kinds of tumor, and sickness rate occupies the first place of head-neck malignant tumor, and has increase trend, serious threat people ' s health and life.Along with radiotherapy apparatus and the development of technology and the accumulation of clinical experience, though survival rate comparatively before be improved, its 5 years survival rates are still less than 50%, and 10 years survival rates are especially less than 30%, and 5 years survival rates of advanced NPC are lower.The new prophylactico-therapeutic measures of further investigation nasopharyngeal carcinoma, significant to the cure rate and minimizing treatment side reaction improving nasopharyngeal carcinoma.
The while of radiocurable, use in conjunction radiosensitizer is considered to the important measures reducing radiation opposing, improve Radiotherapy.From the fifties in last century, the concept of radiosensitizer be suggested and be applied to gradually clinical in.The maximum radiosensitizer applied clinically is now some traditional or novel chemotherapeutics, and it has obvious cytotoxicity.Therefore need to find a kind of toxicity less, and there is the medicine of better radiosensitizing effect.
Summary of the invention
The present invention is the radiosensitivity being used for improving nasopharyngeal carcinoma applied in clinical position, reduces ray to a kind of Chinese medicine composition of Normocellular damage and Chinese medicine preparation.The present invention aims to provide little, the cheap Chinese medicine preparation of a kind of good effect, side effect.Another object of the present invention is to the preparation method that above-mentioned preparation is provided.
The present invention is by the following technical solutions:
A Chinese medicine composition for nasopharyngeal carcinoma radiation sensitization, is made up by ratio of weight and the number of copies of following raw material of Chinese medicine: Radix Trichosanthis 14-16 part, Radix Astragali 14-16 part, Rhizoma Atractylodis Macrocephalae 9-15 part, Rhizoma Anemarrhenae 9-15 part, Radix Saposhnikoviae 7-10 part, Radix Rehmanniae 7-10 part, Radix Pseudostellariae 7-10 part, Radix Rehmanniae Preparata 7-10 part, Radix Angelicae Sinensis 7-10 part, Radix Scrophulariae 5-8 part, Radix Paeoniae 4-7 part.
Preferably, a Chinese medicine composition for nasopharyngeal carcinoma radiation sensitization, is made up by ratio of weight and the number of copies of following raw material of Chinese medicine: Radix Trichosanthis 15 parts, the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Rhizoma Anemarrhenae 10 parts, Radix Saposhnikoviae 8 parts, 8 parts, the Radix Rehmanniae, Radix Pseudostellariae 8 parts, 8 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 8 parts, Radix Scrophulariae 6 parts, Radix Paeoniae 4 parts.
Through lot of experiment validation and analysis, each crude drug of this weight proportion is combined, best for strengthening radiocurable curative effect in nasopharyngeal carcinoma radiotherapy, is more conducive to reducing radiocurable side reaction.
A Chinese medicine preparation for nasopharyngeal carcinoma radiation sensitization, the Chinese medicine composition described in employing is that main active prepares.
The dosage form of the Chinese medicine preparation of described nasopharyngeal carcinoma radiation sensitization can be various kind, and be tablet, pill, capsule, powder or granule, preferred dosage form is granule, has the features such as extraction effect is good, preparation technology is simple.
The Chinese medicine preparation preparation method of described nasopharyngeal carcinoma radiation sensitization, comprises the following steps:
Get Radix Trichosanthis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Pseudostellariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Paeoniae add water retting 30 ~ 60min, decoct, extract several times, obtain extracting solution; Merge extractive liquid, centrifugalize or sedimentation filter, and concentrated filtrate, adds adjuvant, with ethanol soft material, granule processed, dry, obtain the Chinese medicine preparation of nasopharyngeal carcinoma radiation sensitization.
Preferably, described dip time is 45min, and the number of times of extraction is 2 times, 16 ~ 20 mesh sieve granules (being more preferably 16 orders), and less than 40 DEG C dry.Through experimental verification and analysis, the extraction effect of this condition is better.
Described adjuvant is one or more of dextrin, sucrose, soluble starch and beta cyclodextrin.
Chinese medicine composition of the present invention is in the application of the medicine of preparation nasopharyngeal carcinoma radiation sensitization.The medicine of Chinese medicine preparation of the present invention and other nasopharyngeal carcinoma radiation sensitizations is used in conjunction with each other, and is used for preparing the medicine of pharyngeal cancer radiation sensitization.
The pharmacological action of each crude drug in the present invention:
Radix Trichosanthis, sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Function: clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
The Radix Astragali, sweet, tepor.Return lung, spleen channel.Function: tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Weak in the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, and arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and does not hold back.
The Rhizoma Atractylodis Macrocephalae, bitter, sweet, temperature.Return spleen, stomach warp.Function: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
The Rhizoma Anemarrhenae, bitter, sweet, cold.Return lung, stomach, kidney channel.Function: clearing away heat-fire, nourshing Yin and drynsessmoistening prescription.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Radix Saposhnikoviae, pungent, sweet, tepor.Return bladder, liver, spleen channel.Function: expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
The Radix Rehmanniae, sweet, cold.GUIXIN, liver, kidney channel.Function: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Enter nutrient blood for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, constipation is hindered in Tianjin, fever due to yin deficiency, and hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst.
Radix Pseudostellariae, sweet, micro-hardship, flat.Return spleen, lung meridian.Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Radix Rehmanniae Preparata, sweet, tepor.Return liver, kidney channel.Enrich blood YIN nourishing, beneficial essence fills out marrow.For blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, dizzy, tinnitus, early whitening of beard and hair.
Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Scrophulariae, sweet, bitter, salty, be slightly cold.Return lung, stomach, kidney channel.Clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens.Enter nutrient blood for heat, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.
Radix Paeoniae, picric acid is slightly cold.Return Liver Channel.Effect: easing the affected liver to relieve pain treating the liver discomfort in the stomach costa sternales pain; Tonifying blood and regulating menstruation controls the metrorrhagia of blood deficiency menoxenia dysmenorrhea; The headache for the treatment of the liver deficiency of YIN and excessive rising of liver-YANG of yin nourishing suppressing the hyperactive liver, dizzy.
The invention has the beneficial effects as follows:
(1) the present invention is according to the ultimate principle of Chinese medicine, Traditional Chinese Medicine Mechanisms during nasopharyngeal carcinoma radiotherapy, generally can be summarized as pyretic toxicity damage, deficiency of qi and yin.Nasopharyngeal carcinoma their early stage is vital QI being weakened and pathogen being violent, therefore applies pyretic toxicity---ray is with eliminating evil, but ray also just can hindered, and makes healthy energy more empty, and pyretic toxicity impairment of YIN, make deficiency of qi and yin.Therefore only have supplementing QI and nourishing YIN could reduce the side effect of radiotherapy, improve curative effect.Nasopharyngeal carcinoma radiation sensitization Chinese medicine preparation is made up of Radix Trichosanthis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Pseudostellariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Paeoniae.Wherein Radix Trichosanthis and the Radix Astragali are principal agent, and Radix Trichosanthis can clearing away heat and promoting production of body fluid, nourshing Yin and drynsessmoistening prescription.According to our early-stage Study, the monomer trichosanthin of Radix Trichosanthis obviously can suppress growth and the clonality of nasopharyngeal carcinoma cell, causes the apoptosis of nasopharyngeal carcinoma cell, can lower Notch signal path simultaneously.The research of our the past simultaneously also finds that lowering Notch signal path can cause the ratio of nasopharyngeal carcinoma tumor stem cell to decline, and suppresses the growth of nasopharyngeal carcinoma, strengthens nasopharyngeal carcinoma cell to radiation-sensitive.And the Radix Astragali has the effect of strongly invigorating primordial QI, share with Radix Trichosanthis, play effect of supplementing QI and nourishing YIN.Previously research also finds that the Chinese medicine containing the Radix Astragali has good radiosensitizing effect to nasopharyngeal carcinoma cell.Principal agent replenishing QI to invigorate the spleen assisted by Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, replenishing YIN and removing heat, Radix Scrophulariae and can yin nourishing sore-throat relieving, is ministerial drug altogether.Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae nourish blood tonifying YIN, are adjuvant drug.Radix Saposhnikoviae wind-expelling pain-stopping, pungent loose property makes all building up one's health by taking tonic and oiliness, for making medicine.
(2) the present invention selects pure natural Chinese herbal medicine, traditionally theory of Chinese medical science prescription, Chinese medicine preparation is made in conjunction with modern production process, there is replenishing QI to invigorate the spleen, nourish blood the merit of tonifying YIN, heat-clearing and toxic substances removing, wind-expelling pain-stopping, and its evident in efficacy, safety non-toxic is a radiation sensitization Chinese medicine safely and effectively, the curative effect of nasopharyngeal carcinoma radiotherapy can be improved, reduce side reaction.
Indication comprises in the incidence radiation therapy processes such as nasopharyngeal carcinoma and coordinates this medicinal application.
(3) nasopharyngeal carcinoma radiation sensitization Chinese medicine composition of the present invention its there is good radiosensitizing effect, the sensitivity of nasopharyngeal carcinoma cell to ray can be strengthened, reduce the damage of normal structure simultaneously, especially obvious to the damage of minimizing skin, mucosa, reduce radiocurable side reaction.Research proves, nasopharyngeal carcinoma radiation sensitization Chinese medicine preparation is a radiation sensitization Chinese medicine safely and effectively, can improve the curative effect of nasopharyngeal carcinoma radiotherapy.The features such as it is good that preparation method of the present invention has extraction effect, and preparation technology is simple.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
A Chinese medicine preparation for nasopharyngeal carcinoma radiation sensitization, is made up by ratio of weight and the number of copies of following raw material of Chinese medicine: Radix Trichosanthis 15 parts, the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Rhizoma Anemarrhenae 10 parts, Radix Saposhnikoviae 8 parts, 8 parts, the Radix Rehmanniae, Radix Pseudostellariae 8 parts, 8 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 8 parts, Radix Scrophulariae 6 parts, Radix Paeoniae 4 parts.
The preparation method of the Chinese medicine preparation of this nasopharyngeal carcinoma radiation sensitization is comprise the following steps:
Get Radix Trichosanthis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Pseudostellariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Paeoniae add water retting 45min, decoct twice, 2 hours first times, second time 1 hour, collecting decoction, filters, filtrate is concentrated into the clear paste that relative density is 1.30 ~ 1.35 (50 ~ 60 DEG C), qinghuo reagent 1 part, with sucrose 2 parts, 1 part, dextrin and ethanol in proper amount soft material, cross 14 mesh sieve granules, 60 DEG C of dryings, mixing, obtains the Chinese medicinal granule of nasopharyngeal carcinoma radiation sensitization.
Embodiment 2
A Chinese medicine preparation for nasopharyngeal carcinoma radiation sensitization, is made up by ratio of weight and the number of copies of following raw material of Chinese medicine: Radix Trichosanthis 14 parts, the Radix Astragali 14 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, the Rhizoma Anemarrhenae 9 parts, Radix Saposhnikoviae 7 parts, 7 parts, the Radix Rehmanniae, Radix Pseudostellariae 7 parts, 7 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 7 parts, Radix Scrophulariae 5 parts, Radix Paeoniae 4 parts.
The preparation method of the Chinese medicine preparation of this nasopharyngeal carcinoma radiation sensitization is comprise the following steps:
Get Radix Trichosanthis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Pseudostellariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Paeoniae add water retting 30min, decoct, extract 2 times, obtain extracting solution; Merge extracted twice liquid, centrifugalize, concentrated filtrate, filter, filtrate is concentrated into the clear paste that relative density is 1.30 ~ 1.35 (50 ~ 60 DEG C), qinghuo reagent 1 part, with sucrose 2 parts, 1 part, dextrin and ethanol in proper amount soft material, 18 mesh sieve granules, less than 40 DEG C dry, obtains the Chinese medicinal granule of nasopharyngeal carcinoma radiation sensitization.
Embodiment 3
A Chinese medicine preparation for nasopharyngeal carcinoma radiation sensitization, is made up by ratio of weight and the number of copies of following raw material of Chinese medicine: Radix Trichosanthis 16 parts, the Radix Astragali 16 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, the Rhizoma Anemarrhenae 15 parts, Radix Saposhnikoviae 10 parts, 10 parts, the Radix Rehmanniae, Radix Pseudostellariae 10 parts, 10 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 10 parts, Radix Scrophulariae 8 parts, Radix Paeoniae 7 parts.
The preparation method of the Chinese medicine preparation of this nasopharyngeal carcinoma radiation sensitization is comprise the following steps:
Get Radix Trichosanthis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Pseudostellariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Paeoniae add water retting 60min, dipping 45min, decoct twice, 2 hours first times, second time 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.30 ~ 1.35 (50 ~ 60 DEG C), qinghuo reagent 1 part, with sucrose 2 parts, 1 part, dextrin and ethanol in proper amount soft material, cross 14 mesh sieve granules, 60 DEG C of dryings, mixing, obtains the Chinese medicinal granule of nasopharyngeal carcinoma radiation sensitization.
Clinical efficacy:
(1) clinical data
According to the diagnostic criteria of anticancer association of country nasopharyngeal carcinoma, select Shandong University's attached Qianfo Mount hospital application of radiation treatment, and the Nasopharyngeal Carcinoma Patients 79 for the treatment of with chemotherapy of being unwilling is routine, all patient's pathology is diagnosed as nasopharyngeal carcinoma, and Karnofsk scoring >=80 points, sign Informed Consent Form after entering group.All patients are divided into two groups according to computer random order, wherein matched group 40 example, Chinese drug-treated group 39 example, Chinese drug-treated group application of radiation treats the nasopharyngeal carcinoma radiation sensitization granule therapy added in embodiment 1, and the control group radiotherapy adds placebo granulation treatment.
(2) therapeutic scheme
According to result of clinical detection design irradiation fields such as CT, MRI or endoscopy results.Matched group: adopt the conventional external radiotherapy of linear accelerator, irradiation field comprises nasopharynx primary tumor, basis cranii and cervical metastasis stove.Chinese drug-treated group applies nasopharyngeal carcinoma radiation sensitization granule in application first 3 days of roentgenotherapia and Patients During Radiotherapy, and each bag, often wraps 14g, every day three times, until radiotherapy terminates two weeks.
(3) clinical indexes and method
During efficacy evaluation, adopt nasopharyngeal endoscope, MRI (or CT) and B ultrasonic, record nasopharynx part primary tumor and cervical metastasis stove (metastatic lymph node) reduce situation, evaluate criterion according to international bodies tumor to judge, be divided into complete incidence graph (CR), partial rcsponse (CR), stable (SD), progress (PD), total effective rate (RR) refers to that complete incidence graph adds the percentage rate of partial rcsponse (CR+PR).Toxicity grade scale is evaluated with reference to U.S. radiotherapy cooperation tissue (RTOC) grade scale, marks, carry out blood routine examination weekly at treatments period to patient to the skin of patient, oral cavity and digestive tract reaction etc.Within every 2 weeks, carry out inspection hepatic and renal function and electrocardiogram.Before evaluation time is set as treatment patients, after radiotherapy to 50Gy and radiotherapy 3 months.
(4) statistical method
All enumeration data application chi-square criterions, the statistics application SPSS19.0 of all clinical datas completes.
2. result:
The basic condition of 2.1 patients
All patients all can completed treatment according to plan, and can complete 3 months follow up a case by regular visits to.Long term follow-up well afoot.The basic condition of two groups of patients is in table one.
Table one 2 groups of patient clinical datas compare
The short term effect of 2.22 groups of patients
After three months, we compare the nasopharynx part focus of patient and the lymph node situation of cervical region in radiotherapy, find that two groups of patients have obvious difference (table two).The total effective rate at Chinese drug-treated group patient local and cervical metastasis stove place is apparently higher than matched group, and this proves that Chinese medicine can improve radiocurable curative effect.
Table two 2 groups of patients are (3 months) comparitive study in the recent period
The toxicity of 2.3 liang of group patients compares
The main toxicity of radiotherapy is skin, mucosa, salivary gland and leukocytic minimizing, and general radiotherapy there will be significant reaction to 50Gy, and therefore we compare the situation (table three) of radiotherapy to two groups of radiotherapy toxic side effects to 50Gy.Can find in skin, mucosa, salivary gland and leukocytic minimizing, two groups of comparing differences obviously (P < 0.05).And two groups of patients occur that the ratio of gastrointestinal reaction is low and slight, and two groups of patient's no significant differences (P > 0.05), platelet and the hemoglobin reduction situation of two groups of patients are also smaller, but two groups of patients have obvious difference (P < 0.05).
After table three 2 groups of radiotherapies, toxicity compares
By above result, we can find out, nasopharyngeal carcinoma radiation sensitization granule of the present invention its there is good radiosensitizing effect, the sensitivity of nasopharyngeal carcinoma cell to ray can be strengthened, reduce the damage of normal structure simultaneously, especially obvious to the damage of minimizing skin, mucosa.Our research proves, nasopharyngeal carcinoma radiation sensitization granule is a radiation sensitization Chinese medicine safely and effectively, can improve the curative effect of nasopharyngeal carcinoma radiotherapy.The features such as it is good that preparation method of the present invention has extraction effect, and preparation technology is simple.
Claims (10)
1. the Chinese medicine composition of a nasopharyngeal carcinoma radiation sensitization, it is characterized in that, be made up by ratio of weight and the number of copies of following raw material of Chinese medicine: Radix Trichosanthis 14-16 part, Radix Astragali 14-16 part, Rhizoma Atractylodis Macrocephalae 9-15 part, Rhizoma Anemarrhenae 9-15 part, Radix Saposhnikoviae 7-10 part, Radix Rehmanniae 7-10 part, Radix Pseudostellariae 7-10 part, Radix Rehmanniae Preparata 7-10 part, Radix Angelicae Sinensis 7-10 part, Radix Scrophulariae 5-8 part, Radix Paeoniae 4-7 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: be made up by ratio of weight and the number of copies of following raw material of Chinese medicine: Radix Trichosanthis 15 parts, the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Rhizoma Anemarrhenae 10 parts, Radix Saposhnikoviae 8 parts, 8 parts, the Radix Rehmanniae, Radix Pseudostellariae 8 parts, 8 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 8 parts, Radix Scrophulariae 6 parts, Radix Paeoniae 4 parts.
3. a Chinese medicine preparation for nasopharyngeal carcinoma radiation sensitization, is characterized in that: adopt the Chinese medicine composition according to any one of claim 1 ~ 2 to be that main active prepares.
4. Chinese medicine preparation as claimed in claim 3, is characterized in that: the dosage form of the Chinese medicine preparation of described nasopharyngeal carcinoma radiation sensitization is tablet, pill, capsule, powder or granule.
5. Chinese medicine preparation as claimed in claim 4, is characterized in that: the dosage form of the Chinese medicine preparation of described nasopharyngeal carcinoma radiation sensitization is granule.
6., as the preparation method of the Chinese medicine preparation of the nasopharyngeal carcinoma radiation sensitization as described in arbitrary in claim 3 or 5, it is characterized in that, comprise the following steps:
Get Radix Trichosanthis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Pseudostellariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Paeoniae add water retting 30 ~ 60min, decoct, extract several times, obtain extracting solution; Merge extractive liquid, centrifugalize or sedimentation filter, and concentrated filtrate, adds adjuvant, with ethanol soft material, granule processed, dry, obtain the Chinese medicine preparation of nasopharyngeal carcinoma radiation sensitization.
7. preparation method as claimed in claim 6, it is characterized in that: described dip time is 45min, the number of times of extraction is 2 times, 16 ~ 20 mesh sieve granules, and less than 40 DEG C dry.
8. preparation method as claimed in claim 6, is characterized in that: described adjuvant is one or more of dextrin, sucrose, soluble starch or beta cyclodextrin.
9. the Chinese medicine composition described in claim 1 or 2 is in the application of the medicine of preparation nasopharyngeal carcinoma radiation sensitization.
10. apply as claimed in claim 9, it is characterized in that: in claim 3 ~ 5, the medicine of arbitrary described Chinese medicine preparation and other nasopharyngeal carcinoma radiation sensitizations is used in conjunction with each other.
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| CN102526498A (en) * | 2012-02-21 | 2012-07-04 | 姜永华 | Chinese medicine for eliminating toxic and side effects after nasopharyngeal carcinoma radiotherapy and preparation method and administration way thereof |
| CN103550506A (en) * | 2013-11-03 | 2014-02-05 | 崔合芳 | Traditional Chinese medicine composition cooperatively used in radiotherapy |
| CN104740348A (en) * | 2015-04-13 | 2015-07-01 | 刘培进 | Medicine matched with radioactive therapy for nasopharyngeal carcinoma |
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Application publication date: 20151223 |
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