CN105168147A - Pharmaceutical cefetamet pivoxil hydrochloride composite granule for treating bacterial infection - Google Patents
Pharmaceutical cefetamet pivoxil hydrochloride composite granule for treating bacterial infection Download PDFInfo
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- CN105168147A CN105168147A CN201510574680.2A CN201510574680A CN105168147A CN 105168147 A CN105168147 A CN 105168147A CN 201510574680 A CN201510574680 A CN 201510574680A CN 105168147 A CN105168147 A CN 105168147A
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- pivoxil hydrochloride
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Abstract
The invention relates to a pharmaceutical cefetamet pivoxil hydrochloride composite granule for treating bacterial infection, which belongs to the technical field of medicine. The composite granule is prepared from cefetamet pivoxil hydrochloride, sodium citrate, citric acid, saccharose, polyvinylpolypyrrolidone, absolute ethanol, lauryl sodium sulfate and concentrated vanilla. The cefetamet pivoxil hydrochloride is a novel crystal compound and is different from that reported in the prior art, and an X-ray powder diffraction pattern which is obtained by using Cu-Kalpha ray measurement is shown in Figure 1; experiments find that the cefetamet pivoxil hydrochloride granule prepared from the novel crystal compound contains a small quantity of high-molecular polymers and has good stability, and the content of the high-molecular polymers is slightly increased along with the extension of storage time; additionally, the composite granule has obvious antimicrobial activity on pneumococci and hemophilus influenzae and has strong antimicrobial activity on enterococcus and staphylococci.
Description
Technical field
The invention belongs to medical art, relate to a kind of medicine Cefetamet Pivoxil Hydrochloride composition granule for the treatment of bacteriological infection.
Background technology
Cefetamet Pivoxil Hydrochloride is third generation broad-spectrum cephalosporin class antibiotic.The cefetamet being hydrolyzed to rapidly antibacterial activity after oral in vivo plays bactericidal action.Cefetamet Pivoxil Hydrochloride is to gram positive bacterias such as Streptococcus (except streptococcus faecalis), streptococcus pneumoniae, and have very strong antibacterial activity to escherichia coli, Klebsiella, hemophilus influenza, Diplococcus gonorrhoeae, especially obvious to the antibacterial activity of the low Serratia of cephalosporin sensitivity, indole-positive Bacillus proteus, Enterobacter and citric acid Pseudomonas.Bacteriogenic beta-lactamase is stablized.Cefetamet Pivoxil Hydrochloride is invalid to Pseudomonas, mycoplasma, chlamydia, enterococcus and drug resistance staphylococcus.
But because its basic structure is the same with antibiotic in the many semisynthetic beta-lactam gone on the market, Cefetamet Pivoxil Hydrochloride also can form high molecular polymer, also can cause type Ⅰ hypersensitivity reaction in Clinical practice, very harmful to patient.Prior art improves its stability from aspects such as raising content, reduction impurity mostly.
Research proves, the anaphylactogen causing beta-lactam antibiotic type Ⅰ hypersensitivity reaction is relevant with the high molecular polymer content wherein existed.Reduce the high molecular polymer content existed in Cefetamet Pivoxil Hydrochloride crude drug, improve stability, make it can ensure the lower effective way being the reaction of reduction anaphylactic shock and occurring of the content of its high molecular polymer existed in long term storage.Therefore, be necessary to provide the cefetamet pivoxil hydrochloride compound that a kind of high molecular polymer content is low, performance is more superior.
Summary of the invention
Goal of the invention of the present invention is to provide a kind of medicine Cefetamet Pivoxil Hydrochloride composition granule for the treatment of bacteriological infection.
In order to complete object of the present invention, the technical scheme of employing is:
The present invention relates to a kind of medicine Cefetamet Pivoxil Hydrochloride composition granule for the treatment of bacteriological infection, described composition granule is made up of Cefetamet Pivoxil Hydrochloride, sodium citrate, citric acid, sucrose, polyvinylpolypyrrolidone, dehydrated alcohol, sodium lauryl sulphate, vanilla; Described Cefetamet Pivoxil Hydrochloride is crystal, and the X-ray powder diffraction pattern that the measurement of use Cu-K alpha ray obtains as shown in Figure 1.
First optimal technical scheme of the present invention is: with parts by weight, and described composition granule is made up of the Cefetamet Pivoxil Hydrochloride of 1-1.5 weight portion, the sodium citrate of 4.30-4.36 weight portion, the citric acid of 2.3-2.7 weight portion, the sucrose of 8-12 weight portion, the polyvinylpolypyrrolidone of 1.5-2.5 weight portion, the dehydrated alcohol of 6-10 weight portion, the sodium lauryl sulphate of 0.15-0.25 weight portion, the vanilla of 0.15-0.25 weight portion.
Second optimal technical scheme of the present invention is: with parts by weight, and described composition granule is made up of the Cefetamet Pivoxil Hydrochloride of 1.25 weight portions, the sodium citrate of 4.33 weight portions, the citric acid of 2.5 weight portions, the sucrose of 10 weight portions, the polyvinylpolypyrrolidone of 2 weight portions, the dehydrated alcohol of 8 weight portions, the sodium lauryl sulphate of 0.2 weight portion, the vanilla of 0.2 weight portion.
3rd optimal technical scheme of the present invention is: the preparation method of described composition granule comprises the following steps:
1) supplementary material process: with vibration screen-dividing machine, sucrose is crossed 60 mesh sieves, Cefetamet Pivoxil Hydrochloride crosses 80 mesh sieves;
2) weigh: weigh according to recipe quantity;
3) granulate: the Cefetamet Pivoxil Hydrochloride of recipe quantity, sodium citrate, citric acid, sucrose, polyvinylpolypyrrolidone are joined in wet granulator, open stirring motor and be dry mixed 5 minutes, add the dehydrated alcohol of recipe quantity, wet mixing cutting 160-180 soft material second, 16 order nylon wires are arranged in oscillating granulator granulates;
4) drying and screening: arranging boiling drier inlet temperature is 55 DEG C, is dried to moisture < 2.5%, granule after drying is placed in vibration screen-dividing machine and sieves, sieve gets granule between 16-30 order;
5) mix: join in three-dimensional motion mixer by 120,000 base sodium sulfate of the dry granule after sieving and recipe quantity, vanilla, main frame frequency 50Hz, mixes 30 minutes;
6) pack: mixed granule is joined in particles packing machine, control content uniformity in acceptability limit.
4th optimal technical scheme of the present invention is: the preparation method of the crystal of described Cefetamet Pivoxil Hydrochloride comprises the following steps:
(1) by Cefetamet Pivoxil Hydrochloride dissolution of crystals in the mixed solvent of methanol and diisopropyl ether, the solvent load that needs of every gram of Cefetamet Pivoxil Hydrochloride is 90ml, and the volume ratio of methanol and diisopropyl ether is 5:1;
(2), after being heated to 35 DEG C of dissolvings, after cool to room temperature, crystal seed is added;
(3) be cooled to less than 0 DEG C, stirring and crystallizing, the temperature of crystallize is-15 DEG C, filters, dry, collects crystal and namely obtains Cefetamet Pivoxil Hydrochloride crystal.
The polymorphism of solid chemical is the natural phenomena that a kind of general material exists, this phenomenon refers to that a kind of solid chemical can exist 2 kinds or two or more crystal form state, be also called the polymorphic state of material, the polymorphic state of material is also referred to as " allomorphism " phenomenon.Although its chemical nature of allomorphous solid matter is identical, its physicochemical property may be different.For " allomorphism medicine " that physicochemical property is different, also can show the curative effect of different disease preventing and treating clinically, directly affect application and the clinical effectiveness of medicine.
Because the basic structure of Cefetamet Pivoxil Hydrochloride is the same with antibiotic in the many semisynthetic beta-lactam gone on the market, also type Ⅰ hypersensitivity reaction can be caused in Clinical practice, very harmful to patient.Research proves, the anaphylactogen causing beta-lactam antibiotic type Ⅰ hypersensitivity reaction is relevant with the high molecular polymer content wherein existed.But prior art improves its stability from aspects such as raising content, reduction impurity mostly, does not propose any improvement to high molecular polymer content wherein.
The present inventor obtains a kind of Cefetamet Pivoxil Hydrochloride novel crystal forms structure being different from prior art through a large amount of tests, and by test, show that this novel crystal forms structure not only has lower high molecular polymer content, and increase seldom along with its high molecular polymer content of prolongation of period of storage.
Simultaneously, the present inventor passes through In vitro Bactericidal Experiments, surprisingly find, cefetamet pivoxil hydrochloride compound provided by the present invention has more significant antibacterial activity to streptococcus pneumoniae, hemophilus influenza, and also has stronger antibacterial activity to the Cefetamet Pivoxil Hydrochloride of prior art report without the enterococcus of antibacterial activity, staphylococcus.
Compared with prior art, tool of the present invention has the following advantages:
(1) cefetamet pivoxil hydrochloride compound provided by the present invention is crystal compound, it is a kind of cefetamet pivoxil hydrochloride compound being different from prior art report, find through test, this Cefetamet Pivoxil Hydrochloride crystal compound is compared compared with the cefetamet pivoxil hydrochloride compound of prior art, not only there is lower high molecular polymer content, and increase seldom along with its high molecular polymer content of prolongation of period of storage, obtained granule has good stability, the advantages such as impurity content is low;
(2) cefetamet pivoxil hydrochloride compound provided by the present invention has more significant antibacterial activity to streptococcus pneumoniae, hemophilus influenza, and also has stronger antibacterial activity to the Cefetamet Pivoxil Hydrochloride of prior art report without the enterococcus of antibacterial activity, staphylococcus.
Accompanying drawing explanation
Fig. 1 is the X-ray powder diffraction that the Cefetamet Pivoxil Hydrochloride crystal of the embodiment of the present invention 1 preparation uses the measurement of Cu-K alpha ray to obtain.
Detailed description of the invention
Below by specific embodiment, summary of the invention of the present invention is described in further detail, but does not therefore limit content of the present invention.
embodiment 1:the preparation of Cefetamet Pivoxil Hydrochloride crystal
(1) by Cefetamet Pivoxil Hydrochloride dissolution of crystals in the mixed solvent of methanol and diisopropyl ether, the solvent load that needs of every gram of Cefetamet Pivoxil Hydrochloride is 90ml, and the volume ratio of methanol and diisopropyl ether is 5:1;
(2), after being heated to 35 DEG C of dissolvings, after cool to room temperature, crystal seed is added;
(3) be cooled to less than 0 DEG C, stirring and crystallizing, the temperature of crystallize is-15 DEG C, filters, dry, collects crystal and namely obtains Cefetamet Pivoxil Hydrochloride crystal.
As shown in Figure 1, its purity of high-performance liquid chromatogram determination is 99.8% to the X-ray powder diffraction pattern that the Cefetamet Pivoxil Hydrochloride crystal prepared uses the measurement of Cu-K alpha ray to obtain.
embodiment 2:the preparation of Cefetamet Pivoxil Hydrochloride granule
Prescription: with parts by weight, the Cefetamet Pivoxil Hydrochloride 1.25 parts that embodiment 1 is obtained, sodium citrate 4.30 parts, citric acid 2.3 parts, sucrose 8 parts, polyvinylpolypyrrolidone 1.5 parts, dehydrated alcohol 6 parts, sodium lauryl sulphate 0.15 part, vanilla 0.15 part.
Preparation method:
1) supplementary material process: with vibration screen-dividing machine, sucrose is crossed 60 mesh sieves, Cefetamet Pivoxil Hydrochloride crosses 80 mesh sieves;
2) weigh: weigh according to recipe quantity;
3) granulate: the Cefetamet Pivoxil Hydrochloride of recipe quantity, sodium citrate, citric acid, sucrose, polyvinylpolypyrrolidone are joined in wet granulator, open stirring motor and be dry mixed 5 minutes, add the dehydrated alcohol of recipe quantity, wet mixing cutting 160-180 soft material second, 16 order nylon wires are arranged in oscillating granulator granulates;
4) drying and screening: arranging boiling drier inlet temperature is 55 DEG C, is dried to moisture < 2.5%, granule after drying is placed in vibration screen-dividing machine and sieves, sieve gets granule between 16-30 order;
5) mix: join in three-dimensional motion mixer by 120,000 base sodium sulfate of the dry granule after sieving and recipe quantity, vanilla, main frame frequency 50Hz, mixes 30 minutes;
6) pack: mixed granule is joined in particles packing machine, control content uniformity in acceptability limit.
embodiment 3:the preparation of Cefetamet Pivoxil Hydrochloride granule
Prescription: with parts by weight, the Cefetamet Pivoxil Hydrochloride 1.25 parts that embodiment 1 is obtained, sodium citrate 4.33 parts, citric acid 2.5 parts, sucrose 10 parts, polyvinylpolypyrrolidone 2 parts, dehydrated alcohol 8 parts, sodium lauryl sulphate 0.2 part, vanilla 0.2 part.
Preparation method:
1) supplementary material process: with vibration screen-dividing machine, sucrose is crossed 60 mesh sieves, Cefetamet Pivoxil Hydrochloride crosses 80 mesh sieves;
2) weigh: weigh according to recipe quantity;
3) granulate: the Cefetamet Pivoxil Hydrochloride of recipe quantity, sodium citrate, citric acid, sucrose, polyvinylpolypyrrolidone are joined in wet granulator, open stirring motor and be dry mixed 5 minutes, add the dehydrated alcohol of recipe quantity, wet mixing cutting 160-180 soft material second, 16 order nylon wires are arranged in oscillating granulator granulates;
4) drying and screening: arranging boiling drier inlet temperature is 55 DEG C, is dried to moisture < 2.5%, granule after drying is placed in vibration screen-dividing machine and sieves, sieve gets granule between 16-30 order;
5) mix: join in three-dimensional motion mixer by 120,000 base sodium sulfate of the dry granule after sieving and recipe quantity, vanilla, main frame frequency 50Hz, mixes 30 minutes;
6) pack: mixed granule is joined in particles packing machine, control content uniformity in acceptability limit.
embodiment 4:the preparation of Cefetamet Pivoxil Hydrochloride granule
Prescription: with parts by weight, the Cefetamet Pivoxil Hydrochloride 1.25 parts that embodiment 1 is obtained, sodium citrate 4.36 parts, citric acid 2.7 parts, sucrose 12 parts, polyvinylpolypyrrolidone 2.5 parts, dehydrated alcohol 10 parts, sodium lauryl sulphate 0.25 part, vanilla 0.25 part.
Preparation method:
1) supplementary material process: with vibration screen-dividing machine, sucrose is crossed 60 mesh sieves, Cefetamet Pivoxil Hydrochloride crosses 80 mesh sieves;
2) weigh: weigh according to recipe quantity;
3) granulate: the Cefetamet Pivoxil Hydrochloride of recipe quantity, sodium citrate, citric acid, sucrose, polyvinylpolypyrrolidone are joined in wet granulator, open stirring motor and be dry mixed 5 minutes, add the dehydrated alcohol of recipe quantity, wet mixing cutting 160-180 soft material second, 16 order nylon wires are arranged in oscillating granulator granulates;
4) drying and screening: arranging boiling drier inlet temperature is 55 DEG C, is dried to moisture < 2.5%, granule after drying is placed in vibration screen-dividing machine and sieves, sieve gets granule between 16-30 order;
5) mix: join in three-dimensional motion mixer by 120,000 base sodium sulfate of the dry granule after sieving and recipe quantity, vanilla, main frame frequency 50Hz, mixes 30 minutes;
6) pack: mixed granule is joined in particles packing machine, control content uniformity in acceptability limit.
test example 1:high molecular polymer comparision contents is tested
(1) accelerated test
By following each sample temperature 40 DEG C, place 6 months under relative humidity 75% condition, respectively at the 1st, 2,3, sampling in June, according to " HPLC method measures related substance in Cefetamet Pivoxil Hydrochloride and polymer " [
wang Jian,
wangdan is red,
hong Liya.HPLC method measures related substance in Cefetamet Pivoxil Hydrochloride and polymer (J), pharmaceutical analysis magazine, 2015, (2)] measure the content of polymer in each sample, and with 0 day results contrast.Result of the test is shown in Table 1:
Trial target: the Cefetamet Pivoxil Hydrochloride crystal that the embodiment of the present invention 1 is obtained;
Reference substance: commercially available Cefetamet Pivoxil Hydrochloride raw material, is provided by Zhuhai United Laboratories Ltd.
The content of high molecular polymer in table 1 accelerated test each sample
(2) long term test
Each sample at room temperature, respectively at the 3rd, sampling in 6,9,12 months, according to " HPLC method measures related substance in Cefetamet Pivoxil Hydrochloride and polymer " [
wang Jian,
wangdan is red,
hong Liya.HPLC method measures related substance in Cefetamet Pivoxil Hydrochloride and polymer (J), pharmaceutical analysis magazine, 2015, (2)] measure the content of polymer in each sample, and with 0 day results contrast.Result of the test is shown in Table 2:
The assay result of polymer in table 2 long term test each sample
Find out from above-mentioned result of the test, compared with commercially available prod, the polymer content of cefetamet pivoxil hydrochloride compound crystal of the present invention is lower, good stability, and the content of polymer is along with the prolongation of period of storage, and it increases seldom.
test example 2:antibacterial activity is tested
1, materials and methods
1.1 antibacterial
Certain clinical laboratory of institute is collected in the blood of clinical patient, expectorant, secretions, Urine specimens and isolates 84 strain clinical bacterias, through the qualification of VITEK-AMS microbiological analysis instrument, has 24 strain streptococcus pneumoniae, 23 influenzae strain bacillus, 18 strain enterococcus, 19 strain staphylococcuses.Quality-control strains is provided by Ministry of Public Health Clinical Laboratory center.
1.2 culture medium
Isolation medium is 5% blood plate, and drug test MH agar is purchased from Oxoid company.
1.3 antibacterials
Trial target: the Cefetamet Pivoxil Hydrochloride crystal that the embodiment of the present invention 1 is obtained;
Reference substance: commercially available Cefetamet Pivoxil Hydrochloride raw material, by the limited public affairs of the federal pharmacy share in Zhuhai
departmentthere is provided.
1.4 criterion
Standard bacteria and tested bacterium drug sensitivity tests judge by NCCLS standard in 2000.
1.5 statistical method
Calculate Sensitivity rate, medium sensitivity rate, the resistant rate of various antibacterials to different bacterium, and use χ
2check the Sensitivity rate of more each Cefetamet Pivoxil Hydrochloride.
2, the results are shown in Table 3, table 4, table 5, table 6
Table 3 antibacterials are to the pneumococcal antibacterial activity in vitro of 24 strain
Table 4 antibacterials are to the antibacterial activity in vitro of 23 influenzae strain bacillus
Table 5 antibacterials are to the enterococcal antibacterial activity in vitro of 18 strain
Table 6 antibacterials are to the staphylococcic antibacterial activity in vitro of 19 strain
As can be seen from above-mentioned result of the test, the cefetamet pivoxil hydrochloride compound prepared by the present invention has more significant antibacterial activity to streptococcus pneumoniae, hemophilus influenza; Commercially available Cefetamet Pivoxil Hydrochloride is to enterococcus, staphylococcus without antibacterial activity, and Cefetamet Pivoxil Hydrochloride provided by the invention has stronger antibacterial activity to enterococcus, staphylococcus.
Claims (5)
1. treat a medicine Cefetamet Pivoxil Hydrochloride composition granule for bacteriological infection, it is characterized in that: described composition granule is made up of Cefetamet Pivoxil Hydrochloride, sodium citrate, citric acid, sucrose, polyvinylpolypyrrolidone, dehydrated alcohol, sodium lauryl sulphate, vanilla; Described Cefetamet Pivoxil Hydrochloride is crystal, and the X-ray powder diffraction pattern that the measurement of use Cu-K alpha ray obtains as shown in Figure 1.
2. the medicine Cefetamet Pivoxil Hydrochloride composition granule for the treatment of bacteriological infection according to claim 1, it is characterized in that: with parts by weight, described composition granule is made up of the Cefetamet Pivoxil Hydrochloride of 1-1.5 weight portion, the sodium citrate of 4.30-4.36 weight portion, the citric acid of 2.3-2.7 weight portion, the sucrose of 8-12 weight portion, the polyvinylpolypyrrolidone of 1.5-2.5 weight portion, the dehydrated alcohol of 6-10 weight portion, the sodium lauryl sulphate of 0.15-0.25 weight portion, the vanilla of 0.15-0.25 weight portion.
3. the medicine Cefetamet Pivoxil Hydrochloride composition granule for the treatment of bacteriological infection according to claim 2, it is characterized in that: with parts by weight, described composition granule is made up of the Cefetamet Pivoxil Hydrochloride of 1.25 weight portions, the sodium citrate of 4.33 weight portions, the citric acid of 2.5 weight portions, the sucrose of 10 weight portions, the polyvinylpolypyrrolidone of 2 weight portions, the dehydrated alcohol of 8 weight portions, the sodium lauryl sulphate of 0.2 weight portion, the vanilla of 0.2 weight portion.
4. prepare as arbitrary in claim 1-3 as described in the method for medicine Cefetamet Pivoxil Hydrochloride composition granule for the treatment of bacteriological infection, it is characterized in that comprising the following steps:
1) supplementary material process: with vibration screen-dividing machine, sucrose is crossed 60 mesh sieves, Cefetamet Pivoxil Hydrochloride crosses 80 mesh sieves;
2) weigh: weigh according to recipe quantity;
3) granulate: the Cefetamet Pivoxil Hydrochloride of recipe quantity, sodium citrate, citric acid, sucrose, polyvinylpolypyrrolidone are joined in wet granulator, open stirring motor and be dry mixed 5 minutes, add the dehydrated alcohol of recipe quantity, wet mixing cutting 160-180 soft material second, 16 order nylon wires are arranged in oscillating granulator granulates;
4) drying and screening: arranging boiling drier inlet temperature is 55 DEG C, is dried to moisture < 2.5%, granule after drying is placed in vibration screen-dividing machine and sieves, sieve gets granule between 16-30 order;
5) mix: join in three-dimensional motion mixer by 120,000 base sodium sulfate of the dry granule after sieving and recipe quantity, vanilla, main frame frequency 50Hz, mixes 30 minutes;
6) pack: mixed granule is joined in particles packing machine, control content uniformity in acceptability limit.
5. the medicine Cefetamet Pivoxil Hydrochloride composition granule for the treatment of bacteriological infection according to claim 1, it is characterized in that, the preparation method of the crystal of described Cefetamet Pivoxil Hydrochloride comprises the following steps:
(1) by Cefetamet Pivoxil Hydrochloride dissolution of crystals in the mixed solvent of methanol and diisopropyl ether, the solvent load that needs of every gram of Cefetamet Pivoxil Hydrochloride is 90ml, and the volume ratio of methanol and diisopropyl ether is 5:1;
(2), after being heated to 35 DEG C of dissolvings, after cool to room temperature, crystal seed is added;
(3) be cooled to less than 0 DEG C, stirring and crystallizing, the temperature of crystallize is-15 DEG C, filters, dry, collects crystal and namely obtains Cefetamet Pivoxil Hydrochloride crystal.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100484574C (en) * | 2008-02-04 | 2009-05-06 | 山东罗欣药业股份有限公司 | Hydrochloric acid cefetamet pivoxil dispersible tablet and method for preparing the same |
| WO2012060785A1 (en) * | 2010-11-05 | 2012-05-10 | Mahmut Bilgic | Production method for tablets comprising cephalosporin |
| CN104788470A (en) * | 2015-04-30 | 2015-07-22 | 苗怡文 | Cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases |
| CN104800221A (en) * | 2015-05-15 | 2015-07-29 | 苗怡文 | Medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases |
| CN104876947A (en) * | 2015-05-06 | 2015-09-02 | 山东罗欣药业集团股份有限公司 | Cefetamet pivoxil hydrochloride hydrate crystals and dispersible tablet thereof |
-
2015
- 2015-09-11 CN CN201510574680.2A patent/CN105168147A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100484574C (en) * | 2008-02-04 | 2009-05-06 | 山东罗欣药业股份有限公司 | Hydrochloric acid cefetamet pivoxil dispersible tablet and method for preparing the same |
| WO2012060785A1 (en) * | 2010-11-05 | 2012-05-10 | Mahmut Bilgic | Production method for tablets comprising cephalosporin |
| CN104788470A (en) * | 2015-04-30 | 2015-07-22 | 苗怡文 | Cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases |
| CN104876947A (en) * | 2015-05-06 | 2015-09-02 | 山东罗欣药业集团股份有限公司 | Cefetamet pivoxil hydrochloride hydrate crystals and dispersible tablet thereof |
| CN104800221A (en) * | 2015-05-15 | 2015-07-29 | 苗怡文 | Medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases |
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