CN105151342A - Packing method and device for propofol injections - Google Patents
Packing method and device for propofol injections Download PDFInfo
- Publication number
- CN105151342A CN105151342A CN201510412837.1A CN201510412837A CN105151342A CN 105151342 A CN105151342 A CN 105151342A CN 201510412837 A CN201510412837 A CN 201510412837A CN 105151342 A CN105151342 A CN 105151342A
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- CN
- China
- Prior art keywords
- propofol
- syringe
- injection
- plug
- helmet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/1782—Devices aiding filling of syringes in situ
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
- B65B5/04—Packaging single articles
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to the technical field of medicine and provides a packing method for propofol injections. The packing method comprises the steps of medicine liquid filling, deoxygenization, piston installation, sealed storage for prefilled syringes and the like. A packing device for the propofol injections comprises a syringe, a piston, a rubber plug protecting cap and a push rod. A Luer connector is arranged at the top end of the syringe. The outer surface of the Luer connector is sleeved with a spiral connector. The rubber plug protecting cap is installed at the top end of the spiral connector. By means of the packing method for the propofol injections, the waste caused by adsorption or transfer in the using process of the propofol injections can be reduced; repeated suction of the propofol injections in the using process is avoided, and the chances of secondary pollution are reduced; the packing device can be used by medical personnel directly and conveniently, and time for clinical application is saved; the storage time of the propofol injections can be prolonged.
Description
Technical field
The present invention relates to medical art, be specifically related to a kind of packing method and device of propofol injection.
Background technology
Propofol, its chemistry 2,6-diisopropylphenol by name is novel quick, the fugitive intravenous anesthetics of one being commonly used to anesthesia induction, anesthesia maintenance, ICU urgent patient calmness at present clinically.It has anesthesia induction rapid-action, revive rapidly and the advantage such as functional rehabilitation is perfect, and postoperative nausea and vomiting incidence is low.The injecting drug use packaging of Propofol adopts cillin bottle or ampoule always for a long time, inject again after suction syringe during use, when using undiluted propofol injection direct infusion, generally also need to use micro pump or infusion pump, to control infusion rates.Thisly first be stored in by Propofol in cillin bottle or ampoule, the method for taking out note during use again has following shortcoming: 1) Propofol causes waste because sticking in storage and transfer process; 2) process of packaging transfer, sterile liquid medicine and air and other utensils cause secondary pollution; 3) control step is more, expends medical worker's time.The propofol injection of existing use cillin bottle or ampoule packaging is preserved under the environment of 2-25 ° of C in addition, and the shelf-life the longest is 3 years, and for this medicine costly of propofol injection, the shelf-life is too short.
Summary of the invention
For solving the problem, the invention provides a kind of packing method and device of propofol injection, the packing method of this propofol injection can reduce Propofol in storage and transfer process because adsorbing the waste caused; To reduce in propofol injection use procedure swabbing repeatedly, reduce secondary pollution chance; Facilitate medical worker directly to use, save inject time; Because this packaged form can realize zero residual oxygen, can shelf-life of prolongation propofol injection by a relatively large margin.
For realizing such scheme, the packing method of a kind of propofol injection provided by the invention, this packing method comprises the steps:
A. liquid medicine filling: the injection of 50ml Propofol liquid has been installed in the syringe of plug helmet by bottle placer;
B. deoxygenation: by nitrogen replacement, removes the oxygen in syringe to less than 5%;
C. piston is installed: by inhaling vacuum to syringe, making it form negative pressure, being imported by piston;
D. the sealing of pre-encapsulated injector is preserved: use packing bag for medical use filling good pre-encapsulated injector packaging to be preserved.
In technique scheme, described plug helmet and female Luer contact position are provided with protruding screw plug, and female Luer can seal by screw plug completely, and prevent in storage and transport process, liquid spills from female Luer.
In technique scheme, the finished product after sterilizing can be directly used in clinical injection, reduces the waste causing time and liquid in Propofol transfer, and reduces secondary pollution.
The packing device of a kind of propofol injection provided by the invention, described packing device is pre-encapsulated injector, and described pre-encapsulated injector comprises female Luer, screw connection, syringe, piston, push rod and plug helmet.
In technique scheme, the top of described syringe is provided with female Luer, and described female Luer appearance surface cover has screw connection.
In technique scheme, described screw connection inside face has negative thread, plug helmet is connected on screw connection inside face by internal thread rotation, the helmet structure of the buckle-type that negative thread design adopts relative to the pre-embedding of the national plastics such as America and Europe, connect tightr, product, in sterilizing and transportation, is not easy to loosen, thus ensures the pollution not being subject to the external world of medicine.
In technique scheme, the outside face of described plug helmet is carved with rotation screw thread, turns on plug helmet time easy to use.
In technique scheme, described piston face has negative thread or outside thread or without screw thread.
In technique scheme, the manufacture material of described syringe is medium/high Pyrex material, and the chemical inertness of medium/high Pyrex material is high, good with medicine intermiscibility.
In technique scheme, the top of described plug helmet is provided with plastics helmet, and described plastics helmet upper surface is carved with the indicia arrow of hand of rotation, only need turn on plug helmet according to arrow logo, connecting needle or conduit during use, very easy to use.
Beneficial effect of the present invention is:
1) mode of bottle placer quantitative filling liquid is adopted, more accurate than the manual aspiration medicinal liquid of medical personnel;
2) reduce medicine because of the waste stored and the absorption of transfer process causes, especially need Anesthesia medicine accurately for this quantity of Propofol, tool is of great significance;
3) repeatedly aspirate after avoiding using dilution, reduce secondary pollution chance;
4) adopt medium/high Pyrex and the rubber assembly of high-quality, with medicine, there is good compatibility, the stability of the medicine packed can be guaranteed;
5) in injection vessel, directly can indicate nomenclature of drug, not easily mistake occur clinically; If use easy peeling label, also help and preserve patient medication information;
6) easy and simple to handle, the clinical middle time than using the injection drug of cillin bottle or ampoule packaging to save half, be particularly suitable for Emergency Patients;
7) can shelf-life of prolongation propofol injection by a relatively large margin.
Accompanying drawing explanation
Fig. 1 is the structural representation of pre-encapsulated injector in the present invention.
Fig. 2 is the structural representation of plug helmet in the present invention.
Fig. 3 be in the present invention plug helmet and female Luer in conjunction with schematic diagram.
Fig. 4 is the sectional perspective schematic diagram of pre-encapsulated injector in the present invention.
In figure: 1-female Luer, 2-screw connection, 3-syringe, 4-piston, 5-push rod, 6-plug helmet, 61-rotates screw thread, 62-screw plug, 21-negative thread.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, carry out clear, complete description to the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.This area ordinary person, not making the every other embodiment obtained under creative work prerequisite, all belongs to protection scope of the present invention.
Embodiment 1: a kind of packing method of propofol injection
The packing method of a kind of propofol injection provided by the invention, this packing method comprises the steps:
A. liquid medicine filling: the injection of 50ml Propofol liquid has been installed in the syringe 3 of plug helmet 6 by bottle placer;
B. deoxygenation: by nitrogen replacement, removes the oxygen in syringe 3 to less than 5%;
C. piston 4 is installed: by inhaling vacuum to syringe 3, making it form negative pressure, being imported by piston 4;
D. the sealing of pre-encapsulated injector is preserved: use packing bag for medical use filling good pre-encapsulated injector packaging to be preserved.
In technique scheme, Propofol can quantitatively according to the actual requirements be extracted out by described bottle placer from liquid medicine storage tank, adopts the mode of bottle placer quantitative filling liquid, more accurate than the manual aspiration medicinal liquid of medical personnel.
In technique scheme, after bottle placer expendable is shaping, can clinical injection be directly used in, reduce Propofol because absorption causes waste in storage and transfer, and reduce secondary pollution.
Under same stored condition, use this packing method and use common ampoule packing method for the propofol injection shelf-life to affect correlation data as follows:
Experiment condition: this packing method of use of some and the propofol Injection of the same batch using common ampoule packing method are put into the climatic chamber that temperature is set as (25 ± 2) ° C, humidity set is (60 ± 5) % and stores, detect every sampling in 6 months, detect data as follows:
1. the propofol injection observed data using this packing method to store is as follows:
| 1 month | 6 months | 12 months | 18 months | 24 months | 30 months | 36 months | 42 months | 48 months | |
| Content | 100.00% | 100.00% | 99.99% | 99.98% | 99.96% | 99.90% | 99.82% | 99.61% | 99.05% |
| PH | 7.0 | 6.9 | 6.9 | 6.8 | 6.8 | 6.7 | 6.6 | 6.5 | 6.2 |
| Outward appearance | White emulsion | White emulsion | White emulsion | White emulsion | White emulsion | White emulsion | White emulsion | White emulsion | There is demulsifying phenomenon |
| Breast grain (> 5um) | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect |
| Anisidine value (< 3.0) | 2.2 | 2.3 | 2.3 | 2.3 | 2.2 | 2.4 | 2.5 | 2.5 | 2.6 |
2. the propofol injection observed data using common ampoule packing method to store is as follows:
| 1 month | 6 months | 12 months | 18 months | 24 months | 30 months | 36 months | 42 months | 48 months | |
| Content | 100.00% | 100.00% | 99.99% | 99.95% | 99.83% | 99.64% | 99.03% | 98.01% | 96.12% |
| PH | 7.0 | 6.9 | 6.9 | 6.8 | 6.6 | 6.5 | 6.2 | 5.8 | 5.3 |
| Outward appearance | White emulsion | White emulsion | White emulsion | White emulsion | White emulsion | White emulsion | There is demulsifying phenomenon | Breakdown of emulsion is serious | Breakdown of emulsion is serious |
| Breast grain (> 5um) | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Detect | Detect | Detect |
| Anisidine value (< 3.0) | 2.2 | 2.3 | 2.3 | 2.5 | 2.7 | 2.9 | 3.0 | 3.2 | 3.3 |
Experimental result shows: under this experiment condition, the propofol injection using this packing method to store can keep never degenerating for 42 months, the propofol injection using common ampoule packing method to store can only keep never degenerating for 30 months, this packing method, can by the extended shelf-life 40% of propofol injection compared to common ampoule packing method.
Embodiment 2: a kind of packing device of propofol injection
With reference to shown in Fig. 1, described pre-encapsulated injector comprises female Luer 1, screw connection 2, syringe 3, piston 4 and push rod 5.
With reference to shown in Fig. 1, described piston 4 is wrapped in push rod 5 top, and piston 4 and push rod 5 jointly cover are enclosed in syringe 3, and the top of described syringe 3 is provided with female Luer 1, and described female Luer 1 appearance surface cover has screw connection 2.
With reference to shown in Fig. 3 and Fig. 4, described screw connection 2 inside face has negative thread 21, plug helmet 6 is screwed in screw connection 2 inside face by negative thread 21, negative thread 21 designs the helmet structure of the buckle-type adopted relative to the pre-embedding of the national plastics such as America and Europe, connect tightr, product, in sterilizing and transportation, is not easy to loosen, thus ensures the pollution not being subject to the external world of medicine.
With reference to shown in Fig. 2, the top of described plug helmet 6 is provided with plastics helmet, and described plastics helmet upper surface is carved with the indicia arrow of hand of rotation, only need turn on plug helmet 6 according to arrow logo, connecting needle or conduit during use, very easy to use.
With reference to shown in Fig. 2, the outside face of described plug helmet 6 is carved with and rotates screw thread 61, turns on plug helmet 6 time easy to use.
With reference to shown in Fig. 2 and Fig. 3, described plug helmet 6 is provided with protruding screw plug 63 with female Luer 1 contact position, and female Luer 1 can seal by screw plug 63 completely, and prevent in storage and transport process, liquid spills from female Luer 1.
In technique scheme, the manufacture material of described syringe 3 is medium/high Pyrex material, and the chemical inertness of medium/high Pyrex material is high, good with medicine intermiscibility.
In technique scheme, described piston 4 surface has negative thread or outside thread or without screw thread.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, done any amendment, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. a packing method for propofol injection, is characterized in that, this packing method comprises the steps:
Liquid medicine filling: the injection of 50ml Propofol liquid has been installed in the syringe (3) of plug helmet (6) by bottle placer;
Deoxygenation: by nitrogen replacement, removes the oxygen in syringe (3) to less than 5%;
Piston (4) is installed: by inhaling vacuum to syringe (3), making it form negative pressure, being imported by piston (4);
The sealing of pre-encapsulated injector is preserved: use packing bag for medical use filling good pre-encapsulated injector packaging to be preserved.
2. propofol injection packing method as claimed in claim 1, is characterized in that: described propofol injection is the fat emulsion injection of Propofol.
3. propofol injection packing method as claimed in claim 1, is characterized in that: described plug helmet (6) and female Luer (1) contact position are provided with protruding screw plug (62).
4. the packing device of a propofol injection, it is characterized in that: described packing device is pre-encapsulated injector, described pre-encapsulated injector comprises female Luer (1), screw connection (2), syringe (3), piston (4), push rod (5) and plug helmet (6).
5. propofol injection packing device as claimed in claim 3, is characterized in that: the top of described syringe (3) is provided with female Luer (1), and described female Luer (1) appearance surface cover has screw connection (2).
6. propofol injection packing device as claimed in claim 3, it is characterized in that: described screw connection (2) inside face has negative thread (21), plug helmet (6) is screwed in screw connection (2) inside face by negative thread (21).
7. propofol injection packing device as claimed in claim 3, is characterized in that: the outside face of described plug helmet (6) is carved with and rotates screw thread (61).
8. propofol injection packing device as claimed in claim 3, is characterized in that: the manufacture material of described syringe (3) is medium/high Pyrex material.
9. propofol injection packing device as claimed in claim 3, is characterized in that: described piston (4) is for negative thread or outside thread or without screw thread.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510412837.1A CN105151342A (en) | 2015-07-15 | 2015-07-15 | Packing method and device for propofol injections |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510412837.1A CN105151342A (en) | 2015-07-15 | 2015-07-15 | Packing method and device for propofol injections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105151342A true CN105151342A (en) | 2015-12-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510412837.1A Pending CN105151342A (en) | 2015-07-15 | 2015-07-15 | Packing method and device for propofol injections |
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| Country | Link |
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| CN (1) | CN105151342A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078917A (en) * | 2017-12-20 | 2018-05-29 | 远大医药（中国）有限公司 | A kind of preparation method of adrenalin hydrochloride parenteral solution |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4718463A (en) * | 1985-12-20 | 1988-01-12 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
| CN1115973A (en) * | 1993-11-03 | 1996-01-31 | 勃勒柯国际有限公司 | Method for the preparation of pre-filled plastic syringes |
| CN1607968A (en) * | 2001-11-02 | 2005-04-20 | 梅里迪安医学技术公司 | Medicament container, a medicament dispensing kit for administering medication and a method for packaging the same |
| CN102470933A (en) * | 2009-07-03 | 2012-05-23 | 罗伯特·博世有限公司 | Device for filling and sealing pharmaceutical containers |
| CN203677662U (en) * | 2013-11-18 | 2014-07-02 | 苏州林华医疗器械有限公司 | Pre-filling type injection syringe |
-
2015
- 2015-07-15 CN CN201510412837.1A patent/CN105151342A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4718463A (en) * | 1985-12-20 | 1988-01-12 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
| CN1115973A (en) * | 1993-11-03 | 1996-01-31 | 勃勒柯国际有限公司 | Method for the preparation of pre-filled plastic syringes |
| CN1607968A (en) * | 2001-11-02 | 2005-04-20 | 梅里迪安医学技术公司 | Medicament container, a medicament dispensing kit for administering medication and a method for packaging the same |
| CN102470933A (en) * | 2009-07-03 | 2012-05-23 | 罗伯特·博世有限公司 | Device for filling and sealing pharmaceutical containers |
| CN203677662U (en) * | 2013-11-18 | 2014-07-02 | 苏州林华医疗器械有限公司 | Pre-filling type injection syringe |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078917A (en) * | 2017-12-20 | 2018-05-29 | 远大医药（中国）有限公司 | A kind of preparation method of adrenalin hydrochloride parenteral solution |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151216 |
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| RJ01 | Rejection of invention patent application after publication |