CN105148137A - Externally-applied Chinese herbal medicine for treating prostatic hyperplasia - Google Patents
Externally-applied Chinese herbal medicine for treating prostatic hyperplasia Download PDFInfo
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Abstract
The invention relates to the field of medicines for treating prostatic hyperplasia in medical technology, in particular to an externally-applied Chinese herbal medicine for treating prostatic hyperplasia. The Chinese herbal medicine comprises raw materials in parts by mass as follows: 9-15 parts of Chinese honeylocust spine, 9-15 parts of twotooth achyranthes roots, 9-15 parts of epimedium herb, 9-15 parts of weeping forsythiae capsule, 6-12 parts of common burreed rhizome, 6-12 parts of hairyleaf litse fruit, 6-12 parts of figwort roots, 3-7 parts of mole crickets and 3-7 parts of crickets. Compared with the prior art, the Chinese herbal medicine has the benefits as follows: Chinese herbal medicine components are selected according to the traditional Chinese medicine pathology and pathogenesis about prostatic hyperplasia, the formula has the efficacy of kidney yang warming and recuperating, blood activation, detumescence, detoxification, stagnation elimination and diuresis inducing for treating stranguria, and the externally-applied hydrogel patch is prepared by combination of modern extraction techniques and an agent preparation technique. The externally-applied Chinese herbal medicine has a definite treatment function on prostatic hyperplasia and can relieve pain of patients suffering from prostatic hyperplasia.
Description
Technical field
The present invention relates in medical science the drug world for the treatment of prostate and increasing, specifically a kind of Chinese medicinal herb external medicine for the treatment of prostatic hyperplasia.
Background technology
Prostatic hyperplasia is the common disease of male.According to statistics, its sickness rate is that 61 ~ 70 years old person accounts for 50.0%, and within 71 ~ 80 years old, person accounts for 57.1%, and within 81 ~ 90 years old, person reaches 83.3%, and along with China enters aging society, the sickness rate of prostatic hyperplasia will sharply increase further.The clinical symptoms of prostatic hyperplasia comprises: 1. urine storage phase symptom, as frequent micturition, urgent micturition, nocturia increase and urinary incontinence; 2. to urinate phase symptom, occur dysuria as urination time extend, range is not far, urine line is thin and unable, urine bifurcated and vesical tenesmus are felt; 3. post micturition symptoms, generation urine retention, residual urine increase; 4. other symptoms, as hematuria, urinary system infection, vesical calculus, renal function injury, lower urinary tract obstruction etc.In addition, research finds that prostatic hyperplasia is the important risk factor of carcinoma of prostate morbidity, and therefore, prostatic hyperplasia brings misery and burden greatly to patient, has had a strong impact on the quality of life of patient.
Prostatic hyperplasia belongs to the category such as " difficulty in urination " in Chinese medicine, " incontinence ", " incontinence of urine ", " abdominal mass is amassed ", and its pathogenesis key is deficiency in origin and excess in superficiality, and deficiency in origin is based on insufficiency of kidney-YANG, kidney qi virtual loss, and mark reality is solidifying, damp and hot based on blood stasis, expectorant.Doctor trained in Western medicine is then thought, with advancing age, testosterone, dihydrotestosterone and estrogenic change are the Important cause of diseases of prostatic hyperplasia; Also find that the inflammatory factor that various inflammatory cell produces and various enzyme cause the hypertrophy of prostate epithelial cell or Interstitial cell, cause prostatic hyperplasia.
For prostatic hyperplasia, current clinical general employing operative therapy and Drug therapy.Surgical result is better, but painful large, easy damaged vigour, patient not easily accepts and compliance is lower; Although than very fast, there is larger toxic and side effects owing to needing long-term taking, as lesions of liver and kidney and GI irritation etc. in the treatment speed of Western medicine.Chinese herbal medicine has the comprehensive function feature of multicomponent, Mutiple Targets, many effects, emphasis be the total synergy effect of bodily tissue inside, treating both the principal and secondary aspects of a disease, and side effect is little or nothing.Particularly external treatment of tcm have easy to use, evident in efficacy, not impairing the liver kidney, painlessly wait bitterly for remarkable advantage, as applied administration by meridian point note, also there is the synergism that acupoint stimulation superposes with drug effect, therefore, be research emphasis and the focus of field of medicaments in recent years.Qing Dynasty's Xu Dachun cloud: " medicine deficiency is to the greatest extent sick ... with plaster it, its gas inaccessible, makes medicine enter its space between skin and muscles from pore, dredge the meridian passage, or carries it, or lose and loose it, comparatively take medicine particularly strong "; " external treatment doctor say " records " reason of external treatment, the i.e. reason for the treatment of by oral administration of medicines, the medicine of external treatment, the i.e. medicine for the treatment of by oral administration of medicines.Different person, method ear ", all highlight external treatment and the concordance of internal treatment in the cause of disease, pathogenesis, diagnosis and prescription etc., solid theoretical basis has been established in the development for Chinese herbal medicine transdermal administration.Therefore, the Chinese medicinal herb external medical instrument of active development treatment prostatic hyperplasia has important social meaning.
Summary of the invention
The present invention, in order to solve current clinical employing operative therapy and Drug therapy prostatic hyperplasia Problems existing, provides a kind of Chinese medicinal herb external medicine for the treatment of prostatic hyperplasia.
The present invention is achieved by the following technical solutions: a kind of Chinese medicinal herb external medicine for the treatment of prostatic hyperplasia, and its Chinese herbal medicine is made up of the raw material of following masses part,
Spina Gleditsiae 9 ~ 15 parts, Radix Achyranthis Bidentatae 9 ~ 15 parts, Herba Epimedii 9 ~ 15 parts, Fructus Forsythiae 9 ~ 15 parts, Rhizoma Sparganii 6 ~ 12, Semen Impatientis 6 ~ 12 parts, clear Fructus Solani melongenae 6 ~ 12 parts, Radix Scrophulariae 6 ~ 12 parts, Gryllotalpa 3 ~ 7 parts, Gryllus Chinensis 3 ~ 7 parts.
The Spina Gleditsiae that the present invention adopts, Radix Achyranthis Bidentatae, Herba Epimedii, Fructus Forsythiae, Rhizoma Sparganii, Semen Impatientis, clear Fructus Solani melongenae, Radix Scrophulariae, Gryllotalpa, Gryllus Chinensis, wherein Spina Gleditsiae has effect of detoxification evacuation of pus, promoting blood circulation and detumescence, as " book on Chinese herbal medicine is high former " is recorded: " removing air slaking expectorant; relieve internal heat counteracting toxic substances ", " book on Chinese herbal medicine converges and says " is recorded: " Fructus Gleditsia acupuncture is drawn out pus by applying a plaster to the affected part and dispeled the wind.The non-one-tenth person of all carbuncle, can draw to dissipate, will the person of breaking, can draw to lift one's head, routed person can draw with row pus; Be first want agent in infections poison ", can be used for carbuncle sore tumefacting virus, scrofula or difficulty in discharging of pus person.Radix Achyranthis Bidentatae has blood circulation promoting and blood stasis dispelling, tonifying liver and kidney and strengthening bones and muscles, inducing diuresis for treating stranguria syndrome, draw blood ignites descending effect, as " Mingyi Bielu " is recorded: " middle weak breath of curing the wound; male kidney yin disappears, and old man loses excessive, invigorating middle warmer is absolutely continuous; fill out bone marrow ", " Records of Tradition Chinese and Western Medicine in Combination " is recorded: " Radix Achyranthis Bidentatae was the product of tonification originally, and the bet of kind bleed blood; be with medication for its lower passerby, permanent with for tying-in.Kind controlling drenches pain, tonneau urine, this all its power be apt to descending effect also ", can be used for main soreness of waist and knee joint, flaccidity and weakness of the lower limbs, blood stasis, pyretic stranguria, stranguria with blood, traumatic injury and carbuncle malignant boil etc.Herba Epimedii has effect of kidney invigorating and YANG supporting, expelling wind and removing dampness, as " herbal classic " is recorded: " main impotence is hindered absolutely, pains in the penis.Diuresis, physical strength profiting, strong will ", " book on Chinese herbal medicine justice " is recorded: " special invigorating kidney-YANG, therefore main impotence, say exhausted the wounded for Herba Epimedii, the pungent temperature of natural disposition, and namely the wound absolutely of male sexuality is also; Pains in the penis, the also deficiency and coldness of kidney; Diuresis person, refer to that the male sexuality of old man and deficiency and coldness people is depressed, urine sound of rain pattering person says it, obtains its subsidy kidney yang and normal urination ", can be used for controlling that sexual impotence erectile problem, dribbling urination, muscles and bones contraction are anxious, weakness of the waist and knees and rheumatic arthralgia etc.Fructus Forsythiae has effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, as " property of medicine book on Chinese herbal medicine " is recorded: " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat ", can be used for carbuncle, scrofula sucutaneous nodule, warmly to join the army, high hot excessive thirst and pyretic stranguria urine retention etc.; Rhizoma Sparganii has effect of removing blood stasis, promoting the circulation of QI to relieve pain, as " Bencao Jingshu " is recorded: " Rhizoma Sparganii, then controls blood from blood medicine, then controls gas from gas medicine; Old addiction lump in the abdomen caking, do not have and can't help caused by blood stasis, depressed, food stop, hardship can be let out and pungent energy falls apart, Gan Nenghe and enter spleen, blood pertaining to YIN and tangible, this is so can control all condensations and stagnate tangible heavily fortified point and amass also ", can be used for lump in the abdomen, coagulation of QI-blood, traumatic injury and skin ulcer and swell hard etc.Semen Impatientis has effect of removing blood stasis removing food stagnancy, hard masses softening and resolving, as " book on Chinese herbal medicine justice " is recorded: " grind into powder and endure patch affected part, pole can softening hardness and disperse swelling ", and " herbal classic is met former " is recorded: " softening the hard mass, searches pertinacious phlegm, lower stillborn fetus ", Ke Yu WEIJIA mass in the abdomen, amenorrhea and dysphagic etc.Clear Fructus Solani melongenae has warming middle-JIAO to relieve pain, promoting flow of QI and blood, relievings asthma, effect of diuresis, as " the southern regions of the Yunnan Province book on Chinese herbal medicine " is recorded: " tremble with fear pain in the face of controlling; warm waist kidney and Xing Yangdao; control sexual impotence ", " Guangxi Chinese medicinal herbal " is recorded: " diuresis of dispeling cold; parasite killing, disappear legendary venomous insect ", can be used for coldness and pain in the epigastrium, colic of cold type stomachache, cold-damp dropsy, dysuria and turbid urine etc.Radix Scrophulariae has effect of clearing away heat and nourishing YIN, detoxicating and resolving stagnation of pathogens, as Compendium of Material Medica is recorded: " nourishing YIN to lower pathogenic fire; separate speckle poison; throat; diuresis stasis ", " medicine origin " is recorded: " controlling the tired and insomnia of the regretful Nang of the heart, wild utterly confused; stasis dysuria ", can be used for that impairment of YIN is thirsty, laryngopharynx swelling and pain, carbuncle sore tumefacting virus and scrofula sucutaneous nodule etc.Gryllotalpa has inducing diuresis to remove edema and treating stranguria effect, as Compendium of Material Medica is recorded: " sharp defecation, logical stranguria caused by urinary stone, controls scrofula ", can be used for edema, stranguria caused by urinary stone and the difficulty in urination.Gryllus Chinensis has effect of inducing diuresis to remove edema, as supplementary Amplifications of the Compendium of Materia Medica is recorded: " property tonneau, controls anuria ", can be used for that urine retention is obstructed, edema and ascites, and normal is use with Gryllotalpa mutual reinforcement between, treats the difficulty in urination.Medicine-feeding is closed and with it, has the effect of " warming and recuperating the kidney-YANG, promoting blood circulation and detumescence, detoxicating and resolving stagnation of pathogens, inducing diuresis for treating stranguria syndrome " in span of the present invention, therefore, prostatic hyperplasia is had to the effect for the treatment of both the principal and secondary aspects of a disease.
Said herbal medicine raw material interpolation pharmaceutic adjuvant can be made any one and be applicable to clinical external-use drug form, such as external-applied ointment, tincture, paste etc.
Further, the invention provides a kind of preparation method for the treatment of the Chinese herbal medicine hydrogel patch of prostatic hyperplasia, the steps include:
Step 1: take Gryllotalpa and Gryllus Chinensis, be ground into fine powder, for subsequent use;
Step 2: take Spina Gleditsiae, Radix Achyranthis Bidentatae, Herba Epimedii, Fructus Forsythiae, Rhizoma Sparganii, Semen Impatientis, clear Fructus Solani melongenae, Radix Scrophulariae, after mixing, be 75% ~ 90% soak with ethanol 0.5 ~ 1.0 hour by the concentration of mixing medical material weight 6 ~ 12 times, reflux, extract, 1.0 ~ 2.0 hours, extracts 2 times altogether, is merged by 2 ethanol extracts, reclaim ethanol and be concentrated into clear paste, while hot step 1 gained Gryllotalpa and Gryllus Chinensis fine powder added wherein and mix, obtaining Chinese medicine extract, for subsequent use;
Step 3: take the sodium polyacrylate NP-800 of 1 ~ 3 part, the sodium polyacrylate NP-700 of 1 ~ 3 part, the aluminum glycinate of 0.35 ~ 0.65 part, the disodiumedetate of 0.03 ~ 0.09 part, the titanium dioxide of 3 ~ 7 parts, after mix homogeneously, join in the glycerol of 50 ~ 70 parts, under vacuum-0.06MPa condition, stir 3 ~ 10min, obtain glycerol phase, for subsequent use;
Step 4: take the PVP K-90 of 7 ~ 10 parts, the tartaric acid of 0.35 ~ 0.65 part, join in the purified water of 35 ~ 60 parts, be slowly stirred to and be sufficiently uniformly dissolved, obtain aqueous phase, for subsequent use;
Step 5: take the ethyl hydroxybenzoate of 0.2 ~ 0.4 part, 95% ethanol of 1 ~ 2 part, and ethyl hydroxybenzoate is joined in ethanol, be stirred to and be uniformly dissolved, obtain ethanol phase, for subsequent use;
Step 6: the step 1 gained Chinese medicine extract taking 20 ~ 45 parts, and glycerol phase Chinese medicine extract, step 5 gained ethanol phase, step 4 gained aqueous phase joined successively in step 3, under vacuum-0.06MPa condition, stir 8 ~ 15min, obtain medicine carrying substrate, for subsequent use;
Step 7: step 6 gained medicine carrying substrate is transferred on coating cutting machine, after coating cutting, then under being placed in temperature 28 ~ 35 DEG C, humidity 55 ~ 60% condition, leave standstill and be packaged in aluminum-plastic composite membrane bag after 24 hours, obtain the hydrogel patch of this Chinese herbal medicine.
Hydrogel patch of the present invention is relative to other external-use drug forms, its preparation have employed the pharmaceutic adjuvant with skin good biocompatibility, make pharmaceutic adjuvant of the present invention have safe, non-stimulated, apply comfortable feature without irritated with note, meet patient and fear the painful large psychological characteristics of operative therapy, it also avoid Long-term Oral pharmaceutical preparation and can produce pessimal stimulation to gastrointestinal tract and the drawback increasing the weight of Liver and kidney burden, therefore, patient compliance is high, is beneficial to disease treatment.
Further, in described step 3, titanium dioxide can be replaced ceramics or kaolin.PVP K-90 in described step 4 can be replaced polyvinylpyrrolidone K-60 or PVP K-12 0.
The present invention compared with prior art, its beneficial effect had is: choose herbal prescription according to the Chinese medicine pathology and disease mechanism of prostatic hyperplasia and clinical application for many years experience, effect that full side has " warming and recuperating the kidney-YANG, promoting blood circulation and detumescence, detoxicating and resolving stagnation of pathogens, inducing diuresis for treating stranguria syndrome ", then be prepared into exterior-applied liquid medicine gel adhesive through modern extraction technique and preparation technique.The present invention compensate for that operative therapy is painful large, easy damaged vigour and the lower drawback of patient compliance; Solve the problems such as the use inconvenience of oral drugs existence, lesions of liver and kidney and GI irritation; Also solve the stimulation that traditional patch exists as rubber paste and black plaster irritated, take off from time to pull off the feather of pain and the drawback such as Drug Percutaneous Absorption efficiency is low.The present invention has definite therapeutical effect for prostatic hyperplasia, can remove the misery of Patients with Prostatic Hyperplasia.
The beneficial effect that Chinese medicinal herb external medical instrument of the present invention has is further illustrated below from clinical practice result:
1. clinical patients data:
Random collecting object of study is 30 routine male patients, and patient age is 45 ~ 78 years old, all meets " new Chinese medicine guideline of clinical investigations " tcm diagnosis standard: 1. urine meaning is frequently anxious, repeatedly firmly urinates but difficulty in urination goes out, and drop is smooth or inaccessible obstructed; 2. swollen full, the distending pain of lower abdomen; Though 3. urinate difficulty but do not accompany Urethra astringent pain; 4. remaining urine is had through looking into bladder.According to difficulty in urination state of an illness weight classification scoring method (seeing the following form), severe 10 example, moderate 14 example, slight 6 examples.
difficulty in urination state of an illness weight stage division table
| 0 point | 1 point | 2 points | 3 points | |
| To urinate situation | Normally | Urine thin is wire | Urine stream intermittently becomes line | Urine flow point can not drip line |
| Lower abdomen symptom | Asymptomatic | Full vexed sense | Swollen, full | Swollen, full, bitterly |
| Urination time (s) | <40 | 40~50 | 51~60 | >60 |
| Residual urine volume (mL) | <10 | 10~50 | 51~100 | >100 |
Attention: slight≤7 points, moderate 8 ~ 10 points, severe >=11 point.
2. method:
2.1 administrated methods:
SHENQUE acupoint (umbilicus) area skin is thin and vascularity is very abundant, is conducive to Drug Percutaneous Absorption and plays drug effect.Propose the theory of " medicine is entered by umbilicus, is tantamount to entrance also " according to " gas leads to hundred arteries and veins, the cloth vital organs of the human body for umbilicus person, interrenal qi, for life is basic " with " Li Yue Pianwen, Rhymed Discourse for Topical Remedies ", select SHENQUE acupoint to be medicine-feeding part of the present invention.Cleaned by Patients with Prostatic Hyperplasia SHENQUE acupoint area skin, note applies hydrogel patch of the present invention, within every 2 days, changes 1 time, within 30 days, is a course for the treatment of.
2.2 curative effect judging standards:
1. clinic control: cardinal symptom and sign disappear, integration decline 90% and more than, physical and chemical index recovers normal;
2. effective: cardinal symptom and sign major part disappear, and integration declines 60 ~ 89%, and physical and chemical index is normal;
3. effective: cardinal symptom and sign part alleviate or disappear, integration declines 15 ~ 59%, and physical and chemical index takes a turn for the better to some extent;
4. invalid: cardinal symptom and sign unchanged, even increase the weight of.
3. therapeutic outcome
After the treatment of 1 course for the treatment of, therapeutic outcome is: clinic control 13 example (43.33%), effective example 11 (36.67%), effective 5 examples (16.67%), and invalid 1 example (3.33%), total effective rate is 96.67%.In addition, all there is not the untoward reaction such as skin irritation, allergy over the course for the treatment of in all patients.
Detailed description of the invention
embodiment 1(every part is 100g)
The preparation method of the Chinese herbal medicine hydrogel patch of described treatment prostatic hyperplasia is:
Step 1: take Gryllotalpa 300g, Gryllus Chinensis 700g, be ground into fine powder, for subsequent use;
Step 2: take Spina Gleditsiae 1500g, Radix Achyranthis Bidentatae 1500g, Herba Epimedii 900g, Fructus Forsythiae 1500g, Rhizoma Sparganii 600g, Semen Impatientis 1200g, clear Fructus Solani melongenae 1000g, Radix Scrophulariae 600g, after mixing, be 90% soak with ethanol 1.0 hours by the concentration of total medical material weight 6 times, reflux, extract, 2.0 hours, extracts 2 times altogether, is merged by 2 ethanol extracts, reclaim ethanol and be concentrated into clear paste, while hot step 1 gained Gryllotalpa and Gryllus Chinensis fine powder added wherein and mix, obtaining Chinese medicine extract, for subsequent use;
Step 3: the sodium polyacrylate NP-800 taking 100g, the sodium polyacrylate NP-700 of 300g, the aluminum glycinate of 65g, the disodiumedetate of 9g, the titanium dioxide of 700g, after mix homogeneously, join in 5000g glycerol, under vacuum-0.06MPa condition, stir 10min, obtain glycerol phase, for subsequent use;
Step 4: the PVP K-90 taking 700g, the tartaric acid of 65g, joins in the purified water of 3500g, is slowly stirred to and is sufficiently uniformly dissolved, obtain aqueous phase, for subsequent use;
Step 5: the ethyl hydroxybenzoate and the 100g95% ethanol that take 20g, and ethyl hydroxybenzoate is joined in ethanol, be stirred to and be uniformly dissolved, obtain ethanol phase, for subsequent use;
Step 6: the step 1 gained Chinese medicine extract taking 2000g, and glycerol phase Chinese medicine extract, step 5 gained ethanol phase, step 4 gained aqueous phase joined successively in step 3, under vacuum-0.06MPa condition, stir 8min, obtain medicine carrying substrate, for subsequent use;
Step 7: step 6 gained medicine carrying substrate is transferred on coating cutting machine, after coating cutting, under being placed in temperature 28 ~ 35 DEG C, humidity 55 ~ 60% condition again, leaving standstill and be packaged in aluminum-plastic composite membrane bag after 24 hours, the Chinese herbal medicine hydrogel patch of prostatic hyperplasia must be treated.
embodiment 2(every part is 100g)
The preparation method of the Chinese herbal medicine hydrogel patch of described treatment prostatic hyperplasia is:
Step 1: take Gryllotalpa 700g, Gryllus Chinensis 300g, be ground into fine powder, for subsequent use;
Step 2: take Spina Gleditsiae 900g, Radix Achyranthis Bidentatae 1000g, Herba Epimedii 1500g, Fructus Forsythiae 900g, Rhizoma Sparganii 1200g, Semen Impatientis 600g, clear Fructus Solani melongenae 600g, Radix Scrophulariae 1200g, after mixing, be 85% soak with ethanol 1.0 hours by the concentration of total medical material weight 10 times, reflux, extract, 1.5 hours, extracts 2 times altogether, is merged by 2 ethanol extracts, reclaim ethanol and be concentrated into clear paste, while hot step 1 gained Gryllotalpa and Gryllus Chinensis fine powder added wherein and mix, obtaining Chinese medicine extract, for subsequent use;
Step 3: the sodium polyacrylate NP-800 taking 300g, the sodium polyacrylate NP-700 of 100g, the aluminum glycinate of 50g, the disodiumedetate of 5g, the potter's clay of 300g, after mix homogeneously, join in 7000g glycerol, under vacuum-0.06MPa condition, stir 3min, obtain glycerol phase, for subsequent use;
Step 4: the PVP K-90 taking 1000g, the tartaric acid of 50g, joins in the purified water of 6000g, is slowly stirred to and is sufficiently uniformly dissolved, obtain aqueous phase, for subsequent use;
Step 5: the ethyl hydroxybenzoate and the 200g95% ethanol that take 40g, and ethyl hydroxybenzoate is joined in ethanol, be stirred to and be uniformly dissolved, obtain ethanol phase, for subsequent use;
Step 6: the step 1 gained Chinese medicine extract taking 4500g, and glycerol phase Chinese medicine extract, step 5 gained ethanol phase, step 4 gained aqueous phase joined successively in step 3, under vacuum-0.06MPa condition, stir 15min, obtain medicine carrying substrate, for subsequent use;
Step 7: step 6 gained medicine carrying substrate is transferred on coating cutting machine, after coating cutting, under being placed in temperature 28 ~ 35 DEG C, humidity 55 ~ 60% condition again, leaving standstill and be packaged in aluminum-plastic composite membrane bag after 24 hours, the Chinese herbal medicine hydrogel patch of prostatic hyperplasia must be treated.
embodiment 3(every part is 100g)
The preparation method of the Chinese herbal medicine hydrogel patch of described treatment prostatic hyperplasia is:
Step 1: take Gryllotalpa 400g, Gryllus Chinensis 400g, be ground into fine powder, for subsequent use;
Step 2: take Spina Gleditsiae 1200g, Radix Achyranthis Bidentatae 1200g, Herba Epimedii 1200g, Fructus Forsythiae 1200g, Rhizoma Sparganii 800g, Semen Impatientis 800g, clear Fructus Solani melongenae 800g, Radix Scrophulariae 800g, after mixing, be 85% soak with ethanol 1.0 hours by the concentration of total medical material weight 10 times, reflux, extract, 1.5 hours, extracts 2 times altogether, is merged by 2 ethanol extracts, reclaim ethanol and be concentrated into clear paste, while hot step 1 gained Gryllotalpa and Gryllus Chinensis fine powder added wherein and mix, obtaining Chinese medicine extract, for subsequent use;
Step 3: the sodium polyacrylate NP-800 taking 150g, the sodium polyacrylate NP-700 of 150g, the aluminum glycinate of 35g, the disodiumedetate of 3g, the potter's clay of 300g, after mix homogeneously, join in 6000g glycerol, under vacuum-0.06MPa condition, stir 5min, obtain glycerol phase, for subsequent use;
Step 4: the polyvinylpyrrolidone K-60 taking 750g, the tartaric acid of 35g, joins in the purified water of 6000g, is slowly stirred to and is sufficiently uniformly dissolved, obtain aqueous phase, for subsequent use;
Step 5: the ethyl hydroxybenzoate and the 150g95% ethanol that take 24g, and ethyl hydroxybenzoate is joined in ethanol, be stirred to and be uniformly dissolved, obtain ethanol phase, for subsequent use;
Step 6: the step 1 gained Chinese medicine extract taking 4000g, and glycerol phase Chinese medicine extract, step 5 gained ethanol phase, step 4 gained aqueous phase joined successively in step 3, under vacuum-0.06MPa condition, stir 15min, obtain medicine carrying substrate, for subsequent use;
Step 7: step 6 gained medicine carrying substrate is transferred on coating cutting machine, after coating cutting, under being placed in temperature 28 ~ 35 DEG C, humidity 55 ~ 60% condition again, leaving standstill and be packaged in aluminum-plastic composite membrane bag after 24 hours, the Chinese herbal medicine hydrogel patch of prostatic hyperplasia must be treated.
embodiment 4(every part is 100g)
The preparation method of the Chinese herbal medicine hydrogel patch of described treatment prostatic hyperplasia is:
Step 1: take Gryllotalpa 700g, Gryllus Chinensis 700g, be ground into fine powder, for subsequent use;
Step 2: take Spina Gleditsiae 1000g, Radix Achyranthis Bidentatae 900g, Herba Epimedii 1500g, Fructus Forsythiae 1100g, Rhizoma Sparganii 900g, Semen Impatientis 900g, clear Fructus Solani melongenae 600g, Radix Scrophulariae 1000g, after mixing, be 75% soak with ethanol 0.5 hour by the concentration of total medical material weight 12 times, reflux, extract, 1.0 hours, extracts 2 times altogether, is merged by 2 ethanol extracts, reclaim ethanol and be concentrated into clear paste, while hot step 1 gained Gryllotalpa and Gryllus Chinensis fine powder added wherein and mix, obtaining Chinese medicine extract, for subsequent use;
Step 3: the sodium polyacrylate NP-800 taking 200g, the sodium polyacrylate NP-700 of 200g, the aluminum glycinate of 45g, the disodiumedetate of 5g, the titanium dioxide of 500g, after mix homogeneously, join in 6500g glycerol, under vacuum-0.06MPa condition, stir 7min, obtain glycerol phase, for subsequent use;
Step 4: the polyvinylpyrrolidone K-60 taking 850g, the tartaric acid of 45g, joins in the purified water of 6500g, is slowly stirred to and is sufficiently uniformly dissolved, obtain aqueous phase, for subsequent use;
Step 5: the ethyl hydroxybenzoate and the 180g95% ethanol that take 32g, and ethyl hydroxybenzoate is joined in ethanol, be stirred to and be uniformly dissolved, obtain ethanol phase, for subsequent use;
Step 6: the step 1 gained Chinese medicine extract taking 3500g, and glycerol phase Chinese medicine extract, step 5 gained ethanol phase, step 4 gained aqueous phase joined successively in step 3, under vacuum-0.06MPa condition, stir 10min, obtain medicine carrying substrate, for subsequent use;
Step 7: step 6 gained medicine carrying substrate is transferred on coating cutting machine, after coating cutting, under being placed in temperature 28 ~ 35 DEG C, humidity 55 ~ 60% condition again, leaving standstill and be packaged in aluminum-plastic composite membrane bag after 24 hours, the Chinese herbal medicine hydrogel patch of prostatic hyperplasia must be treated.
embodiment 5(every part is 100g)
The preparation method of the Chinese herbal medicine hydrogel patch of described treatment prostatic hyperplasia is:
Step 1: take Gryllotalpa 300g, Gryllus Chinensis 300g, be ground into fine powder, for subsequent use;
Step 2: take Spina Gleditsiae 900g, Radix Achyranthis Bidentatae 1500g, Herba Epimedii 1500g, Fructus Forsythiae 1500g, Rhizoma Sparganii 1200g, Semen Impatientis 1200g, clear Fructus Solani melongenae 1200g, Radix Scrophulariae 1200g, after mixing, be 80% soak with ethanol 1.0 hours by the concentration of total medical material weight 10 times, reflux, extract, 1.0 hours, extracts 2 times altogether, is merged by 2 ethanol extracts, reclaim ethanol and be concentrated into clear paste, while hot step 1 gained Gryllotalpa and Gryllus Chinensis fine powder added wherein and mix, obtaining Chinese medicine extract, for subsequent use;
Step 3: the sodium polyacrylate NP-800 taking 150g, the sodium polyacrylate NP-700 of 200g, the aluminum glycinate of 50g, the disodiumedetate of 6g, the titanium dioxide of 500g, after mix homogeneously, join in 6000g glycerol, under vacuum-0.06MPa condition, stir 6min, obtain glycerol phase, for subsequent use;
Step 4: the tartaric acid taking the PVP K-12 0,50g of 700g, joins in the purified water of 5000g, is slowly stirred to and is sufficiently uniformly dissolved, obtain aqueous phase, for subsequent use;
Step 5: the ethyl hydroxybenzoate and the 100g95% ethanol that take 20g, and ethyl hydroxybenzoate is joined in ethanol, be stirred to and be uniformly dissolved, obtain ethanol phase, for subsequent use;
Step 6: the step 1 gained Chinese medicine extract taking 3200g, and glycerol phase Chinese medicine extract, step 5 gained ethanol phase, step 4 gained aqueous phase joined successively in step 3, under vacuum-0.06MPa condition, stir 12min, obtain medicine carrying substrate, for subsequent use;
Step 7: step 6 gained medicine carrying substrate is transferred on coating cutting machine, after coating cutting, under being placed in temperature 28 ~ 35 DEG C, humidity 55 ~ 60% condition again, leaving standstill and be packaged in aluminum-plastic composite membrane bag after 24 hours, the Chinese herbal medicine hydrogel patch of prostatic hyperplasia must be treated.
Claims (4)
1. treat a Chinese medicinal herb external medicine for prostatic hyperplasia, it is characterized in that, its Chinese herbal medicine is made up of the raw material of following masses part,
Spina Gleditsiae 9 ~ 15 parts, Radix Achyranthis Bidentatae 9 ~ 15 parts, Herba Epimedii 9 ~ 15 parts, Fructus Forsythiae 9 ~ 15 parts, Rhizoma Sparganii 6 ~ 12, Semen Impatientis 6 ~ 12 parts, clear Fructus Solani melongenae 6 ~ 12 parts, Radix Scrophulariae 6 ~ 12 parts, Gryllotalpa 3 ~ 7 parts, Gryllus Chinensis 3 ~ 7 parts.
2. the Chinese medicinal herb external medicine for the treatment of prostatic hyperplasia according to claim 1, is characterized in that, the preparation method of its hydrogel patch is:
Step 1: take Gryllotalpa and Gryllus Chinensis, be ground into fine powder, for subsequent use;
Step 2: take Spina Gleditsiae, Radix Achyranthis Bidentatae, Herba Epimedii, Fructus Forsythiae, Rhizoma Sparganii, Semen Impatientis, clear Fructus Solani melongenae, Radix Scrophulariae, after mixing, be 75% ~ 90% soak with ethanol 0.5 ~ 1.0 hour by the concentration of mixing medical material weight 6 ~ 12 times, reflux, extract, 1.0 ~ 2.0 hours, extracts 2 times altogether, is merged by 2 ethanol extracts, reclaim ethanol and be concentrated into clear paste, while hot step 1 gained Gryllotalpa and Gryllus Chinensis fine powder added wherein and mix, obtaining Chinese medicine extract, for subsequent use;
Step 3: take the sodium polyacrylate NP-800 of 1 ~ 3 part, the sodium polyacrylate NP-700 of 1 ~ 3 part, the aluminum glycinate of 0.35 ~ 0.65 part, the disodiumedetate of 0.03 ~ 0.09 part, the titanium dioxide of 3 ~ 7 parts, after mix homogeneously, join in the glycerol of 50 ~ 70 parts, under vacuum-0.06MPa condition, stir 3 ~ 10min, obtain glycerol phase, for subsequent use;
Step 4: take the PVP K-90 of 7 ~ 10 parts, the tartaric acid of 0.35 ~ 0.65 part, join in the purified water of 35 ~ 60 parts, be slowly stirred to and be sufficiently uniformly dissolved, obtain aqueous phase, for subsequent use;
Step 5: take the ethyl hydroxybenzoate of 0.2 ~ 0.4 part, 95% ethanol of 1 ~ 2 part, and ethyl hydroxybenzoate is joined in ethanol, be stirred to and be uniformly dissolved, obtain ethanol phase, for subsequent use;
Step 6: the step 1 gained Chinese medicine extract taking 20 ~ 45 parts, and glycerol phase Chinese medicine extract, step 5 gained ethanol phase, step 4 gained aqueous phase joined successively in step 3, under vacuum-0.06MPa condition, stir 8 ~ 15min, obtain medicine carrying substrate, for subsequent use;
Step 7: step 6 gained medicine carrying substrate is transferred on coating cutting machine, after coating cutting, then under being placed in temperature 28 ~ 35 DEG C, humidity 55 ~ 60% condition, leave standstill and be packaged in aluminum-plastic composite membrane bag after 24 hours, obtain the hydrogel patch of this Chinese herbal medicine.
3. the preparation method of hydrogel patch according to claim 2, is characterized in that, in described step 3, titanium dioxide can be replaced ceramics or kaolin.
4. the preparation method of the hydrogel patch according to Claims 2 or 3, is characterized in that, the PVP K-90 in described step 4 can be replaced polyvinylpyrrolidone K-60 or PVP K-12 0.
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| CN103610861A (en) * | 2013-11-28 | 2014-03-05 | 山西丰源药业有限公司 | Traditional Chinese medicinal naval plaster with effect of promoting digestion and eliminating stagnation |
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| CN107898924A (en) * | 2017-11-03 | 2018-04-13 | 西安医学院 | For treating the Chinese herbal medicine of osteoporosis and its preparation method of gel adhesive |
| CN107898924B (en) * | 2017-11-03 | 2021-02-02 | 西安医学院 | Chinese herbal medicine for treating osteoporosis and preparation method of gel patch thereof |
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