CN105138818B - In conjunction with the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals - Google Patents
In conjunction with the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals Download PDFInfo
- Publication number
- CN105138818B CN105138818B CN201510438667.4A CN201510438667A CN105138818B CN 105138818 B CN105138818 B CN 105138818B CN 201510438667 A CN201510438667 A CN 201510438667A CN 105138818 B CN105138818 B CN 105138818B
- Authority
- CN
- China
- Prior art keywords
- wave
- square
- acquisition card
- brain wave
- computer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The invention discloses a kind of amblyopia assisting in diagnosis and treatment system of combination pattern reversal visual evoked potentioals, computer is for showing that assisting in diagnosis and treatment stimulation figure and system interface are operated for patient or doctor, and the adjustable gridiron pattern of graphic parameter is as diagnostic stimulation source；Square-wave generator by computer drives to generate lock when square wave and input brain wave acquisition card；Brain wave acquisition card is connected with computer, for acquiring and transmitting patient's EEG signals；Photosensitive circuit and square-wave causes square wave by the bright dark variation of gridiron pattern, inputs brain wave acquisition card as calibration signal；Square-wave signal and photosensitive calibration signal when joined lock in the extraction of P-VEP, the starting point of P-VEP waveform can be found more accurately, be conducive to carry out the processing of waveform and the calculating of characteristic value, the screening of stimulation figure is carried out using the characteristic value of P-VEP, auto-changing stimulation graphic parameter is simultaneously delayed according to P100 amplitude than determining optimal stimulation figure, raising therapeutic efficiency.
Description
Technical field
The invention belongs to children's ophthalmology Clinics and Practices equipment, the amblyopia for being related to a kind of combination pattern reversal visual evoked potentioals is auxiliary
Help diagnosis and therapy system.
Background technique
Amblyopia is to endanger one of the eye disease of children's visual development, is often occurred in vision still immature infancy.It is weak
Depending on diagnosis be clinically mostly used exclusive method, i.e., be after excluding specific organic disease, when vision correction is less than 0.8 or more
The conclusion that amblyopia could be descended to diagnose.And for children with amblyopia, more early discovery is more conducive to the treatment of amblyopia.In fact, in China
There are some problems for the morning inspection of underage child amblyopia: on the one hand, some child ages are small, mismatch inspection, lead to diagnostic result
Inaccuracy；On the other hand, subjective factor also has larger impact to inspection result.
Pattern reversal visual evoked potentioals (pattern visual evoked potential), P-VEP are to utilize flipchart
Shape (such as gridiron pattern) stimulates retina, after by view road transmission, the life being recorded on scalp with brain wave acquisition technology
Manage electrical activity.P-VEP is mainly by N75, P100 and N135 etc. at being grouped as.Clinical trial shows that the P100 of amblyopia patient is latent
The volt phase will be longer than normal person, and wave crest amplitude is less than normal person.(Beijing Wu Lezheng, Wu De positive clinic visual electro-physiology [M]
Science Press, 1999.5) therefore, P-VEP can be used as a kind of means for objectively evaluating visual function, and the auxiliary for amblyopia is examined
It is disconnected.But it due to the amplitude very little of P-VEP, is usually submerged in spontaneous brain electricity, so extracting, there are certain difficulties.Common superposition
Technology has ignored the variation of test Evoked ptential every time and repeatedly mind caused by stimulation since the stacking fold of needs
Through fatigue, the waveform of P-VEP will be directly affected.In addition, how to determine that the starting point of P-VEP is also a important in actual acquisition
The problem of, the error due to caused by software inhouse random delay may cause the inaccuracy of final waveform.
The treatment method of amblyopia is still based on traditional means (such as covering, CAM, fine manipulation) at present, Effect value
It must affirm, but there is also some disadvantages.Most of traditional therapies are uninteresting single, are not easy to be received by infant, compliance ratio
It is poor.And traditional means cannot be in conjunction with the feature of each infant respectively, and personalization level is insufficient, and the course for the treatment of is longer, Among Children
It is difficult to adhere to.Relative to traditional treatment means, the interest of children then can be more caused using multimedia treatment amblyopia, improves and complies with
Property.It is automatic to search for maximum amplitude delay than corresponding stimulation graphic parameter as most preferably meanwhile according to the amplitude of P100 delay ratio
Stimulation parameter provides personalized therapy program, can effectively improve therapeutic efficiency.
Summary of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a kind of amblyopias of combination pattern reversal visual evoked potentioals
It is inaccurate to solve the problems, such as that P-VEP is extracted for assisting in diagnosis and treatment system, improves therapeutic efficiency.
In order to reach the above object, the present invention, which adopts the following technical scheme that, to be achieved:
In conjunction with the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals, including computer, display, square-wave generator,
Brain wave acquisition card and photosensitive circuit and square-wave；Computer is operated for display system interface for patient or doctor, adjusting parameter
The gridiron pattern of overturning is generated as diagnostic stimulation source；Square-wave generator by computer drives to generate lock when square wave and input brain
Electric capture card；Brain wave acquisition card is connected with computer, for acquiring and transmitting patient's EEG signals；Photosensitive circuit and square-wave is by chessboard
The bright dark variation of lattice causes square wave, inputs brain wave acquisition card as calibration signal；
Brain wave acquisition card acquires three road signals, and the first via is EEG signals, and the second tunnel is side corresponding with gridiron pattern overturning
Wave signal constitutes relationship when locking with EEG signals；Third road signal is by the bright side for secretly triggering photosensitive circuit and square-wave and issuing of screen
Wave signal, this three roads signal are collected through brain wave acquisition card and reach computer, and the data finally acquired are by filtering and solely
Vertical component extraction, obtain P-VEP waveform, and waveform extracts critical eigenvalue P100 incubation period and crest value accordingly, with waveform and
The form of characteristic value is presented in the display, and the auxiliary diagnosis of amblyopia is carried out by threshold decision.
Further, the brain wave acquisition card use ADS1299 brain wave acquisition card, powered by 6V battery case, through USB interface with
Computer is connected.
Further, the brain wave acquisition card includes three silver disk electrodes, respectively EEG signals negative electrode, anode electrode
And reference electrode.
Further, the photosensitive circuit and square-wave is built using photodiode, by the bright dark variation initiation side of gridiron pattern
Wave.
Further, isolated component extraction algorithm is as follows:
(1), centralization is carried out to the data X of acquisition, makes its mean value 0；
(2), albefaction is carried out to data, X → Z, Z are the data after albefaction；
(3), an initial weight vector W is randomly choosed；
(4), W is enabled*=E { Zg (WTZ)}-E{g′(WTZ)}W；Wherein E { ... } is the fortune for seeking all column vector mean values of matrix
It calculates；{…}TIt is the operation of matrix transposition；G (u)=tanh (u), g ' (u) are g (u) to u derivation；W*For the new value of W；
(5), W=W*/||W*||(||W*| |=(W*·W*)1/2)
(6) if, do not restrain, return to (4) step, the new value of W and old value direction same direction if convergence, i.e., they
Dot product be 1, P-VEP waveform finally can be obtained.
The present invention has following innovative point:
(1) square-wave signal and photosensitive calibration signal when this system joined lock in the extraction of P-VEP, can be more accurate
Ground finds the starting point of P-VEP waveform, is conducive to carry out the processing of waveform and the calculating of characteristic value.
(2) this system has carried out the optimization of P-VEP waveform extracting algorithm, and the method for having used isolated component to extract can lead to
Very few secondary visual stimulus obtains comparatively ideal P-VEP waveform；
(3) this system carries out the screening of stimulation figure by the characteristic value using P-VEP, and auto-changing stimulates figure to join
Number and according to the delay of P100 amplitude than determining optimal stimulation figure；Meanwhile in conjunction with multimedia, this system is easy to be suffered from by amblyopia
Youngster receives, and improves the compliance for the treatment of.
(4) this system is using the objective datas such as P-VEP characteristic value, provides the assistant diagnosis system of a kind of convenience, quantization,
Graphic parameter is stimulated by changing, it is multiple to measure P-VEP waveform, and search is obtained to retina and view road generation maximum journey automatically
The pattern parameter of degree excitation and stimulation, provides personalized therapeutic scheme (realizing with game mode) accordingly, and interest is strong, is easy
Received by children, is conducive to the raising of therapeutic efficiency.
Detailed description of the invention
Fig. 1 is hardware structure diagram of the invention
Fig. 2 is software architecture diagram of the invention
Fig. 3 is system diagnostics flow chart of the invention
Fig. 4 is the flow chart of systematic treating of the invention
Specific embodiment
The present invention is described in further details with reference to the accompanying drawing.
Amblyopia assisting in diagnosis and treatment system in conjunction with pattern reversal visual evoked potentioals include computer, display, square-wave generator,
ADS1299 brain wave acquisition card and photosensitive circuit and square-wave.It can be grasped with display system interface for patient or doctor in computer
Make, after adjusting parameter, can produce the gridiron pattern of overturning, as diagnostic stimulation source.Square-wave generator is by computer drives to produce
Square wave when raw lock.Brain wave acquisition card is powered by 6V battery case, is connected through USB with computer, for acquiring and transmitting EEG signals.
Three road signals are shared on brain wave acquisition card.The first via is EEG signals, and wherein EEG signals cathode connects above the nasion at 5cm,
Anode connects front and back middle line external occipital protuberance upward 10%, and reference electrode lug, which hangs down, to be located；Second road signal is corresponding with gridiron pattern overturning
Square-wave signal, with EEG signals constitute lock when relationship；Third road signal is the side issued by the bright dark triggering photosensitive circuit of screen
Wave signal.This three roads signal is collected through brain wave acquisition card and reaches computer.Computer software part is divided into auxiliary diagnosis portion
Point and treatment part.Wherein auxiliary diagnosis part is extracted by signal collection, signal isolated component, stimulation figure and waveform are shown
It constitutes；Treatment part is made of optimal pictorial stimulus parameter search, customer data base, personalized multi-media.
Acquisition come data pass through computer software processing, including simply filter and isolated component extract, obtain P-
VEP waveform, waveform is accordingly to extract critical eigenvalue P100 incubation period and crest value, and carries out amblyopia by threshold decision
Auxiliary diagnosis.Infant is stimulated with the figure of different parameters respectively later, the multiple groups characteristic value i.e. amplitude of P100 is obtained and prolongs
When ratio.Then the delay of Automatic-searching P100 maximum amplitude is used as than corresponding stimulation parameter to patient view road and view treatment part
Film stimulates maximum parameter, further according to these parameters, adjust multimedia, treats amblyopia with this.
Personalized multi-media therein is the entertaining figure and trivial games of Parameter adjustable.Electrode used by this system is state
Border standard silver disk electrode.
As shown in Figure 1, the hardware of this system is by host, display, brain wave acquisition card, square-wave generator, photosensitive circuit with
And international standard silver disk electrode is constituted.Wherein, display is used to that stimulation figure is presented, and before stimulation, doctor or sufferer can
To carry out the initial setting up of program by host, stimulation starts to be started by the preset shortcut key of program.Silver disk electrode according to
International EEG standard connection connects on the head of infant, and the other end of electrode accesses brain wave acquisition card.Synchronous square-wave generator is by main journey
Sequence control can issue synchronous square wave with the variation of chessboard pattern, brain wave acquisition card is inputted after partial pressure.Using photosensitive
The simple photosensitive circuit that diode is built can cause square wave by the bright dark variation of gridiron pattern, brain electricity is also inputted as calibration signal and is adopted
Truck.And brain wave acquisition card is powered by 6V battery case, is connected through USB with computer, the program of host can control capture card to be adopted
Collection.The data finally acquired after treatment, are presented in the display in the form of waveform and characteristic value.
Wherein brain wave acquisition card is ADS1299 brain wave acquisition external member, and performance indicator is as follows: the acquisition of 8 channels, 24 high-precisions
Analog-digital converter, extremely low 1 μ V of equivalent input noise, every channel 5mW low-power consumption.Square-wave generator consists of two parts, a part
For I/O card, another part is bleeder circuit.The program of brain wave acquisition card and I/O card is all contained in main program, is opened using C#
Hair, can uniformly be controlled.Photosensitive circuit is then to utilize simple square-wave transmission circuit made of photodiode.
Fig. 2 is the main program developed using C#, including two large divisions: auxiliary diagnosis part and treatment part.Wherein assist
Diagnosis of partial is acquired by data, and isolated component extracts, threshold decision, and figure and waveform is stimulated the part composition such as show.Wherein solely
The algorithm of vertical component extraction is as follows:
1, centralization is carried out to the data X of acquisition, makes its mean value 0；
2, albefaction is carried out to data, X → Z, Z are the data after albefaction；
3, an initial weight vector W is randomly choosed；
4, W is enabled*=E { Zg (WTZ)}-E{g′(WTZ)}W；Wherein E { ... } is the operation for seeking all column vector mean values of matrix；
{…}TIt is the operation of matrix transposition；G (u)=tanh (u), g ' (u) are g (u) to u derivation；W*For the new value of W；
5, W=W*/||W*||(||W*| |=(W*·W*)1/2)
If 6, do not restrained, step 4 is returned.Convergence means that the new value of W and old value are directed toward same direction, i.e. their point
Product is 1.
P-VEP waveform finally can be obtained according to the above method.It then can be convenient on the basis of P-VEP is extracted and extract P100
Incubation period and crest value, and preliminary diagnosis is provided according to characteristic value and threshold value comparison.
Treatment part is screened by automatic optimal stimulation parameter, customer data base and personalized multi-media composition.Treatment part
Mainly the characteristic value of figure is stimulated to find out optimal stimulation parameter according to different parameters, and adjust personalized more matchmakers accordingly
Body parameter stimulates infant eyeball.
Fig. 3 is auxiliary diagnostic flow chart, and Fig. 4 is the flow chart for the treatment of.Before diagnosis starts, hardware is carried out according to Fig. 1
Connection.Then, the parameter of doctor or patient's configuration software, i.e. setting overturn tessellated temporal frequency, spatial frequency, face
Color, testing time etc..Configuration enters full frame after completing.It allows person to be checked to loosen, covers at a glance, another eye fixation screen center is red
Point is started to test by shortcut key.After the completion of test, computer can issue prompting sound.Data reach computer through brain wave acquisition card, warp
It crosses simple filtering and isolated component extracts, P-VEP waveform and its characteristic value are presented in screen, while can be stored to the user
In database.Program provides preliminary diagnosis by threshold decision.Therapeutic process then first has to the model of setting stimulation parameter
It encloses, stimulation parameter includes irritating pattern class at present, stimulates graph time frequency, stimulates pattern space frequency, then calls
Diagnostic subroutine, the waveform stored, circulation diagnostic subroutine is until the range that stimulation parameter is more than setting.Program meeting later
Automatic search, analyzes the amplitude delay ratio of the P100 stimulated more each time, and finds maximum amplitude delay than corresponding
Graphic parameter is as optimal stimulation parameter.And adjustment multimedia is gone with optimized parameter, complete personalized amblyopia treatment scheme
Design.
Present system provides the personalized amblyopia treatment systems for combining multimedia software, can be in the base for accurately extracting P-VEP
On plinth, the graphic parameter to view road and retina maximal stimulation is searched for, therapeutic efficiency is improved, system can be placed on after training
It is used in family, more convenient treatment.
Claims (2)
1. combining the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals, it is characterised in that: including computer, display, side
Wave producer, brain wave acquisition card and photosensitive circuit and square-wave, the brain wave acquisition card use ADS1299 brain wave acquisition card, by 6V electricity
The power supply of pond box, is connected through USB interface with computer；Computer is operated for display system interface for patient or doctor, is adjusted
Whole parameter generates the gridiron pattern of overturning as diagnostic stimulation source；Square-wave generator by computer drives to generate lock when square wave simultaneously
Input brain wave acquisition card；Brain wave acquisition card is connected with computer, for acquiring and transmitting patient's EEG signals；Photosensitive circuit and square-wave
Square wave is caused by the bright dark variation of gridiron pattern, inputs brain wave acquisition card as calibration signal；The photosensitive circuit and square-wave is using photosensitive
Diode is built, and causes square wave by the bright dark variation of gridiron pattern；
Brain wave acquisition card acquires three road signals, and the first via is EEG signals, and the second tunnel is square wave corresponding with gridiron pattern overturning letter
Number, relationship when locking is constituted with EEG signals；Third road signal is by the bright square wave letter for secretly triggering photosensitive circuit and square-wave and issuing of screen
Number, this three roads signal is collected through brain wave acquisition card and reaches computer, and the data finally acquired are by filtering and independent point
Amount is extracted, and P-VEP waveform is obtained, and waveform extracts critical eigenvalue P100 incubation period and crest value accordingly, with waveform and feature
The form of value is presented in the display, and the auxiliary diagnosis of amblyopia is carried out by threshold decision；
Wherein, isolated component extraction algorithm is as follows:
(1), centralization is carried out to the data X of acquisition, makes its mean value 0；
(2), albefaction is carried out to data, X → Z, Z are the data after albefaction；
(3), an initial weight vector W is randomly choosed；
(4), W is enabled*=E { Zg (WTZ)}-E{g′(WTZ)}W；Wherein E { ... } is the operation for seeking all column vector mean values of matrix；
{...}TIt is the operation of matrix transposition；G (u)=tanh (u), g ' (u) are g (u) to u derivation；W*For the new value of W；
(5), W=W*/||W*||(||W*| |=(W*·W*)1/2)
(6) if, do not restrain, return to (4) step, the new value of W and old value direction same direction, i.e. their point if convergence
Product is 1, and P-VEP waveform finally can be obtained.
2. the amblyopia assisting in diagnosis and treatment system of combination pattern reversal visual evoked potentioals according to claim 1, it is characterised in that: institute
Stating brain wave acquisition card includes three silver disk electrodes, respectively EEG signals negative electrode, anode electrode and reference electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510438667.4A CN105138818B (en) | 2015-07-23 | 2015-07-23 | In conjunction with the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510438667.4A CN105138818B (en) | 2015-07-23 | 2015-07-23 | In conjunction with the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105138818A CN105138818A (en) | 2015-12-09 |
| CN105138818B true CN105138818B (en) | 2019-02-05 |
Family
ID=54724164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510438667.4A Active CN105138818B (en) | 2015-07-23 | 2015-07-23 | In conjunction with the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105138818B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2648824C1 (en) * | 2017-01-30 | 2018-03-28 | Алина Валерьевна Должич | Method of treating amblyopia in children |
| CN110547760A (en) * | 2019-08-09 | 2019-12-10 | 西安交通大学 | infant amblyopia electroencephalogram objective detector |
| CN110840454B (en) * | 2019-12-21 | 2021-03-23 | 深圳市杰纳瑞医疗仪器股份有限公司 | Electroencephalogram signal acquisition device and method |
| CN113080840B (en) * | 2021-03-23 | 2021-12-28 | 西安交通大学 | Visual acuity objective, rapid and accurate inspection system based on steady-state visual evoked potential |
| CN113180707B (en) * | 2021-04-10 | 2023-08-15 | 西安交通大学 | Visual electrophysiological rapid detector for graphic evoked potential |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903150A (en) * | 2006-05-10 | 2007-01-31 | 上海迪康医学生物技术有限公司 | Method for treating amblyopia of childhood hy variation of space frequency threshold |
| CN201308487Y (en) * | 2008-08-25 | 2009-09-16 | 浙江工业大学 | Amblyopia detecting system based on P-VEP |
-
2015
- 2015-07-23 CN CN201510438667.4A patent/CN105138818B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903150A (en) * | 2006-05-10 | 2007-01-31 | 上海迪康医学生物技术有限公司 | Method for treating amblyopia of childhood hy variation of space frequency threshold |
| CN201308487Y (en) * | 2008-08-25 | 2009-09-16 | 浙江工业大学 | Amblyopia detecting system based on P-VEP |
Non-Patent Citations (4)
| Title |
|---|
| 基于Gabor刺激源的视觉诱发电位提取及其在成人弱视治疗中应用研究;刘钦团;《http://www.ixueshu.com/document/dd0acff6e7505c58318947a18e7f9386.html》;20091110;第4章 |
| 基于P-VEP技术的弱视检查与治疗系统的研制;邱飞岳等;《电子测量与仪器学报》;20060228;第20卷(第1期);36-39 |
| 基于P-VEP技术的弱视电生理检查系统优化研究;李浩君等;《计算机应用与软件》;20090630;第26卷(第6期);88-90 |
| 基于独立分量聚类分析的诱发脑电特征提取技术;綦宏志等;《信息与控制》;20111031;第40卷(第5期);686-691 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105138818A (en) | 2015-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105138818B (en) | In conjunction with the amblyopia assisting in diagnosis and treatment system of pattern reversal visual evoked potentioals | |
| Rossi et al. | Somatosensory processing during movement observation in humans | |
| Saliba et al. | Functional near-infrared spectroscopy for neuroimaging in cochlear implant recipients | |
| CN100496392C (en) | Nerve feedback treating device for insomnia | |
| CN106407733A (en) | Depression risk screening system and method based on virtual reality scene electroencephalogram signal | |
| KR102522726B1 (en) | Brain stimulation device using real-time brain function activity monitoring | |
| CN104965584A (en) | Mixing method for brain-computer interface based on SSVEP and OSP | |
| CN104768449A (en) | Device and method for examining a phase distribution used to determine a pathological interaction between different areas of the brain | |
| CN107281609A (en) | The system and method that a kind of sleep quality improves | |
| CN107041747B (en) | A kind of breathing instruction device for backbone reduction system | |
| CN108335728A (en) | A kind of name of calling out for disturbance of consciousness patient promotees system of waking up | |
| CN105662598B (en) | A kind of cerebral cortex Orientation of functions device, method and system | |
| CN102293647A (en) | Feedback system combining electroencephalogram and functional magnetic resonance signals | |
| US20110282234A1 (en) | Sequential Low Energy Neurofeedback Treatment | |
| CN106821742A (en) | A kind of acupuncture analogy method and device | |
| CN106726536A (en) | A kind of acupuncture analog signal output method and device | |
| CN110859600A (en) | Method for generating electroencephalogram signal, storage medium and electronic equipment | |
| CN114832235A (en) | Multi-point closed-loop stimulation system and method for gait disturbance of Parkinson's disease | |
| CN115253072A (en) | Multi-mode deep electroencephalogram stimulation accurate nerve regulation and control system and method | |
| KR101349748B1 (en) | Brain meridian activity measurement device and measuring method thereof | |
| CN106551786A (en) | A kind of acupuncture analog signal output method and device | |
| CN106943141B (en) | A kind of checking with EMG method device for backbone reduction system | |
| CN107041748B (en) | One kind triggering Magnetotherapeutic apparatus for backbone reduction system electrocardio | |
| CN209490383U (en) | The wearable electric stimulation therapeutic apparatus of autism children based on electro-ocular signal control | |
| CN106901730B (en) | A kind of backbone reduction system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |