CN105126240A - Degradable ultrafine needle piece - Google Patents
Degradable ultrafine needle piece Download PDFInfo
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- CN105126240A CN105126240A CN201410241593.0A CN201410241593A CN105126240A CN 105126240 A CN105126240 A CN 105126240A CN 201410241593 A CN201410241593 A CN 201410241593A CN 105126240 A CN105126240 A CN 105126240A
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- magnesium
- degradable
- magnesium alloy
- micropin
- faller gill
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Abstract
The invention relates to the technical field of medical cosmetology instruments, in particular to a degradable ultrafine needle piece. The degradable ultrafine needle piece consists of degradable magnesium alloy. The magnesium alloy comprises the following chemical elements in parts by weight: 2-5 parts of neodymium, 0.1-0.5 part of zinc, 0.2-0.7 part of zirconium and the balanced magnesium metal. The magnesium alloy has lower corrosion potential, is easy to be corroded in the body of a person, and can be degraded completely and absorbed by the body of the person after being corroded slowly; magnesium is a necessary nutrient element of persons, and participates in energy metabolism of the body of the person; after the magnesium is absorbed by the body of the person, the circumstance that the content of serum magnesium is increased obviously is avoided; and the magnesium alloy has the neodymium which serves as a low alloying element, by the neodymium, the magnesium alloy has a good ageing precipitation strengthening and solution strengthening effect, electrode potential of an alloy matrix is improved, and homogeneous corrosion resistance of the magnesium alloy is improved. By the small amount of the zinc, the strength of the alloy and plastic working capability can be improved.
Description
Technical field
The present invention relates to medical beauty treatment instrument technical field, be specifically related to a kind of degradable ultra micro faller gill.
Background technology
Micropin beautifying technique utilizes microneedle keratodermatitis, for the infiltration of cosmetics provides passage, promotes the transdermal penetration rate of cosmetics, thus promotes cosmetic result.Because micropin is very intensive in actual use procedure, fracture once there is micropin in use, skin can be caused to occur untoward reaction, as dry, red and swollen, even dermatitis can be suffered from, serious then cause disfeaturing or catching, therefore micropin in process of production in order to ensure its not frangibility so the length selected is shorter, although the situation that this mode can effectively avoid micropin to fracture in a large number occurs, but the infiltration effect of cosmetic liqs is also had a greatly reduced quality, its maximum effect cannot be played, therefore existing micropin Shortcomings in use.
Summary of the invention
The object of the invention is to the defect overcoming prior art, a kind of degradable micropin sheet thrusting deep skin is provided.
For achieving the above object, the present invention adopts following technical scheme:
A kind of degradable ultra micro faller gill, be distributed in the micropin composition on faller gill seat primarily of faller gill seat Sum fanction, micropin is made up of degradable magnesium alloy, and this magnesium alloy comprises magnesium metal, neodymium element, zinc element, zr element; Wherein mass percent shared by neodymium element is 2 ~ 5, and mass percent shared by zinc element is 0.1 ~ 0.5, and mass percent shared by zr element is 0.2 ~ 0.7, and all the other are magnesium metal.
Preferred version of the present invention is: shared by the neodymium element of this magnesium alloy, mass percent is 3, and mass percent shared by zinc element is 0.2, and mass percent shared by zr element is 0.4, and all the other are magnesium metal.
The surface roughness of magnesium alloy is 0.08 ~ 0.16 μm.The base diameter of described micropin is 90 ~ 200 microns, is highly 150 ~ 1000 microns, is preferably 50 ~ 500 microns.Micropin top is that a platform does not have needle point, and platform diameter is 6 ~ 50 microns.The platform at micropin top is regular face or irregular, and the shape of micropin is truncated cone.
The present invention has high-ductility and moderate strength, magnesium alloy has lower corrosion potential, easily corrode in human body, after slow corrosion degradable and absorb by human body, magnesium is the necessary nutrient of human body, participate in the energy metabolism in body, and absorption of human body can not cause the obvious rising of serum magnesium content, if the magnesium that the intestines and stomach absorbs increases, then the absorbtivity again of renal tubules just reduces, excretion increases, and makes the magnesium density in blood plasma keep certain, therefore has security performance basis as degradable biomaterial; And magnesium is cheap, cost is lower; The roughness of restriction alloy surface is for reducing the bacterial number be attached on alloy.
This magnesium alloy system with the addition of neodymium element as low alloying element, and adding of neodymium element can ensure that magnesium alloy has good Precipitation strengthening and solid solution strengthening effect, and improves the electrode potential of alloy substrate, improves the general corrosion resistance performance of magnesium alloy; Zinc element is the trace element that Human Physiology needs, and trace adds can improve alloy strength and plastic working ability; Zr element can propose heavy alloyed obdurability and corrosion resistance and the compatibility as grain refiner.
detailed description of the invention:
Can have the object of the present invention, feature and function to make juror and further understand, therefore the present invention program be further described in conjunction with the embodiments:
A kind of degradable ultra micro faller gill, be distributed in the micropin composition on faller gill seat primarily of faller gill seat Sum fanction, micropin is made up of degradable magnesium alloy, and this magnesium alloy comprises magnesium metal, neodymium element, zinc element, zr element; Wherein mass percent shared by neodymium element is 2 ~ 5, and mass percent shared by zinc element is 0.1 ~ 0.5, and mass percent shared by zr element is 0.2 ~ 0.7, and all the other are magnesium metal.
Preferred version of the present invention is: shared by the neodymium element of this magnesium alloy, mass percent is 3, and mass percent shared by zinc element is 0.2, and mass percent shared by zr element is 0.4, and all the other are magnesium metal.
The surface roughness of magnesium alloy is 0.08 ~ 0.16 μm.The base diameter of described micropin is 90 ~ 200 microns, is highly 150 ~ 1000 microns, is preferably 50 ~ 500 microns.Micropin top is that a platform does not have needle point, and platform diameter is 6 ~ 50 microns.The platform at micropin top is regular face or irregular, and the shape of micropin is truncated cone.Micropin adopts platform structure to be at utmost protect the skin of user to avoid causing scuffing, reducing damaging.
Micropin in the past adopts less than 1000 microns usually, and this is to ensure that micropin does not fracture after thrusting skin, but such length governs the assimilation effect of beautifying liquid simultaneously, it cannot be made fully to be supplied to subcutaneous.Therefore the present inventor courageously imagines, and carefully solves, and finds that above-mentioned magnesium alloy can perfect be applied in the making of micropin, and has broken the technical barrier cannot broken through for a long time in the industry.Micropin length is increased substantially, makes the absorbance of beautifying liquid improve more than 40%, even if micropin fractures in use, also can not affect its degraded and absorbed under healthy prerequisite by human body environment.
Embodiment 1:
Method: magnesium alloy of the present invention is made micropin, carries out aseptic operation and is implanted in male rat body after sterilization, often organize 6.After 1 month, carry out CT examination, understood metabolism status and the difference of micropin in rat body by scanning.15 days, within 1 month, shooting X-ray film understood the position of position and the general condition of degraded.At 15 days, within 1 month, detect the blood biochemistry change of electrolyte of rat.And detect the degraded situation of different time micropin, determine its degradation rate.
Experimental result: in rat body, micropin implants side blood for vigorous.Blood electrolyte detects each group and has no notable difference.In rat body, X-ray film takes the photograph sheet display, and when 15 days, magnesium alloy image shows slightly fuzzy, x-ray printing opacity varying degree, and rat tissue's pathological section display, micropin is slowly degraded in rat pulp cavity, and is substantially absorbed into the surrounding tissues, and has no obvious teratocyte.In 1 month, micropin is degradable in rat body.Magnesium alloy micropin can cause the nucleic picked-up of rat local to increase, and show that local metabolic is vigorous, magnesium alloy has the effect promoting the metabolism of rat intracavity.Magnesium alloy micropin is degraded gradually at intracavity, and early stage, degraded was tending towards slow.In degradation process, intraluminal tissue does not all find obvious untoward reaction, has no significant effect the serum liver renal function of experimental animal rat, electrolyte.
Embodiment 2:
Magnesium alloy micropin fumigation and steaming method is sterilized, implanted in White Rabbit body under strict aseptic technique, after operation wound heal, bacterial strain is adjusted to 0.5 Maxwell unit with PBS, antibacterial adopts P62A, the bacterial strains such as 12228, with than turbid instrument, bacterial concentration is diluted to 1x106/ml, inject each bacterial strain 0.8ml respectively on the micropin in experimental rabbit body, physiological saline is as negative control, the X-ray film of experimental rabbit is taken when the 1st, 3 week after bacterial injection, and local tissue pathological slice inspection is done after x line sheet in the 3rd week shooting experimental rabbit body, carry out antibacterial category authentication.
Experimental result: it is identical with other group of alloys material smoothnesss to start magnesium alloy used, found that P62A, 12228 bacterial adhesion there is no significant difference, count of bacteria is at an order of magnitude, and after changing the surface flatness of metal disk, again test, find the more antibacterial of the large sheet metal surface adhesion of roughness, its Adherent bacteria amount number become positive correlation with roughness.
Certainly, these are only better embodiment of the present invention, not limit the scope of application of the present invention with this, therefore, every make in the principle of the invention equivalence change all should be included in protection scope of the present invention.
Claims (8)
1. a degradable ultra micro faller gill, the micropin composition on faller gill seat is distributed in primarily of faller gill seat Sum fanction, the height of micropin is consistent, and it is characterized in that: micropin is made up of degradable magnesium alloy, this magnesium alloy comprises magnesium metal, neodymium element, zinc element, zr element; Wherein mass percent shared by neodymium element is 2 ~ 5, and mass percent shared by zinc element is 0.1 ~ 0.5, and mass percent shared by zr element is 0.2 ~ 0.7, and all the other are magnesium metal.
2. a kind of degradable ultra micro faller gill according to claim 1, it is characterized in that: in described magnesium alloy, shared by neodymium element, mass percent is 3, mass percent shared by zinc element is 0.2, and mass percent shared by zr element is 0.4, and all the other are magnesium metal.
3. a kind of degradable ultra micro faller gill according to claim 1 and 2, is characterized in that: the surface roughness of described magnesium alloy is 0.08 ~ 0.16 μm.
4. a kind of degradable ultra micro faller gill according to claim 1 and 2, is characterized in that: the base diameter of described micropin is 90 ~ 200 microns, is highly 150 ~ 1000 microns.
5. a kind of degradable ultra micro faller gill according to claim 1 and 2, is characterized in that: described micropin top is that a platform does not have needle point, and platform diameter is 6 ~ 50 microns.
6. a kind of degradable ultra micro faller gill according to claim 5, is characterized in that: the platform at described micropin top is regular face or irregular.
7. a kind of degradable ultra micro faller gill according to claim 5, is characterized in that: the shape of micropin is truncated cone.
8. a kind of degradable ultra micro faller gill according to claim 4, is characterized in that: the height of described micropin is 50 ~ 500 microns.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410241593.0A CN105126240A (en) | 2014-06-03 | 2014-06-03 | Degradable ultrafine needle piece |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410241593.0A CN105126240A (en) | 2014-06-03 | 2014-06-03 | Degradable ultrafine needle piece |
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| CN105126240A true CN105126240A (en) | 2015-12-09 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069814A (en) * | 2016-04-07 | 2018-12-21 | 实验室和人们 | Utilize the micropin of biodegradable metal |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1621102A (en) * | 2004-12-13 | 2005-06-01 | 纳生微电子(苏州)有限公司 | Preparing method for epidermis needle and its application |
| CN100998893A (en) * | 2006-12-26 | 2007-07-18 | 重庆大学 | Biodegradable rare earth magnesium alloy material |
| CN101550510A (en) * | 2009-05-08 | 2009-10-07 | 重庆大学 | High intensity degradable biological medical magnesium alloy and preparation method thereof |
| CN101586223A (en) * | 2009-05-14 | 2009-11-25 | 上海交通大学 | Wrought magnesium alloys containing rare earth |
| CN101837145A (en) * | 2010-06-22 | 2010-09-22 | 上海交通大学 | High-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in organism |
| CN102018655A (en) * | 2009-09-17 | 2011-04-20 | 中国科学院理化技术研究所 | Transdermal drug delivery combined preparation |
| US20130035632A1 (en) * | 2011-08-02 | 2013-02-07 | Yu Chris C | Decomposable Apparatus and Methods for Fabricating Same |
| CN103451643A (en) * | 2013-09-02 | 2013-12-18 | 南京工程学院 | Biological magnesium alloy with surface coated with sodium magnesium fluoride film and preparation method thereof |
-
2014
- 2014-06-03 CN CN201410241593.0A patent/CN105126240A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1621102A (en) * | 2004-12-13 | 2005-06-01 | 纳生微电子(苏州)有限公司 | Preparing method for epidermis needle and its application |
| CN100998893A (en) * | 2006-12-26 | 2007-07-18 | 重庆大学 | Biodegradable rare earth magnesium alloy material |
| CN101550510A (en) * | 2009-05-08 | 2009-10-07 | 重庆大学 | High intensity degradable biological medical magnesium alloy and preparation method thereof |
| CN101586223A (en) * | 2009-05-14 | 2009-11-25 | 上海交通大学 | Wrought magnesium alloys containing rare earth |
| CN102018655A (en) * | 2009-09-17 | 2011-04-20 | 中国科学院理化技术研究所 | Transdermal drug delivery combined preparation |
| CN101837145A (en) * | 2010-06-22 | 2010-09-22 | 上海交通大学 | High-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in organism |
| US20130035632A1 (en) * | 2011-08-02 | 2013-02-07 | Yu Chris C | Decomposable Apparatus and Methods for Fabricating Same |
| CN103451643A (en) * | 2013-09-02 | 2013-12-18 | 南京工程学院 | Biological magnesium alloy with surface coated with sodium magnesium fluoride film and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069814A (en) * | 2016-04-07 | 2018-12-21 | 实验室和人们 | Utilize the micropin of biodegradable metal |
| CN109069812A (en) * | 2016-04-07 | 2018-12-21 | 实验室和人们 | Utilize the micropin of biological absorbable metal |
| CN109069812B (en) * | 2016-04-07 | 2021-05-07 | 实验室和人们 | Microneedles using bioabsorbable metals |
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Application publication date: 20151209 |