CN105126174A - Bioabsorbable medical material and preparation method thereof - Google Patents
Bioabsorbable medical material and preparation method thereof Download PDFInfo
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- CN105126174A CN105126174A CN201510527794.1A CN201510527794A CN105126174A CN 105126174 A CN105126174 A CN 105126174A CN 201510527794 A CN201510527794 A CN 201510527794A CN 105126174 A CN105126174 A CN 105126174A
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- polyglycolic acid
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Abstract
The invention discloses a bioabsorbable medical material and a preparation method thereof. The bioabsorbable medical material comprises 2-6 layers of fabric units stacked together, wherein each fabric unit comprises a plurality of scaffolds for tissue engineering, and is formed by polyglycolic acid yarns having weft knitting structures. The preparation method comprises the following steps: (1) carrying out melt spinning on a polyglycolic acid material through a melt spinning machine, and stretching to obtain polyglycolic acid yarns; (2) preparing the polyglycolic acid yarns into the fabric units through a weft knitting method; and (3) carrying out laminating on the 2-6 layers of fabric units through a hot melt adhesive to prepare the tube-shaped or sheet-shaped bioabsorbable medical material. Compared with the prior art, the bioabsorbable medical material has the beneficial effects of high safety performance, good flexibility and ductility, and obvious effects of the scaffolds for tissue engineering.
Description
Technical field
The present invention relates to field of medical article technology, particularly relate to a kind of bioresorbable medical material and preparation method thereof.
Background technology
The section's field of surgery Medical absorbable material that is out at present is widely used, and plays an important role.It is repaired as tissues such as lung, heart, liver, esophagus, gastrointestinal, spleen, pancreas, gallbladder, kidneys for the reinforcement of delicate tissue tangent plane or defect.
Commercially available prod comprises the oxidized regenerated cellulose film of ETHICON company of the U.S., the carboxymethyl cellulose adhesion membrane of GENZYNE company, Absorbable rod non-woven fabrics that Japanese Jun Shi company produces, the speed of Johson & Johnson and the product such as yarn, hemostatic gauze, these products are all make with gauze, medical films and non-woven fabrics craft, there is technique simple, production efficiency advantages of higher.But take weft knitting as the knit product of representative and above-mentioned non-woven fabrics, the products such as gauze are compared has good ductility and elasticity, the soft warm feature of fabric simultaneously, strong with the adhesion of in-vivo tissue, along with the ductility of the movable fabric of tissue is good, because fabric construction mesopore is evenly and than the products such as non-woven fabrics large (hole is at 20-100um), can effectively absorb oozing of blood sepage, and convenient with biological fibrin glue etc. medical adhesive repair with the use of, the tangent plane section being especially applicable to biological tissue and the repairing reinforcement of defect.
In surgical operation, in body, the sewn reinforcement of delicate tissue is the problem do not solved very well always.As pulmonary resection in thoracic surgery, due to rupture of alveoli in bullous resection art and lung volume reduction surgery, lung itself becomes very fragile, therefore as postoperative duration leaks gas, there is gas leakage infectious-related complication quite serious, extended hospital stay can be caused even dead, the thicker fabric that multilamellar can be adopted to crimp in this type of operation, to sew up the incision position by surgical sutures, or adopt and by the comparatively flimsy material applying biological albumin glue of two-layer crimping or medical adhesive, fabric is stained with in incision or hole for nailing, reach the effect preventing from leaking gas.In liver surgery, liver section is dealt with improperly and gallbladder can be caused to leak, hemorrhage, infects, the situations such as heating, increases medical treatment cost, affects patient and recovers, apply this product can prevent oozing of blood sepage at section part, reduce postoperative hemorrhage, the generation of the phenomenons such as gallbladder leakage.In other operation of department of general surgery, apply this product can play the effect preventing oozing of blood sepage, just the distinctive Weft-knitted Structure of outer this product can be used as the support that histiocyte is produced, and can promote the healing of section and otch.This product is wrapped on spinal column or tendon, effectively can prevent the adhesion at tissue and this position.In addition antibiotic etc solution impregnation can be played in this product the Co ntrolled release effect of medicine, reduce the infection rate at this position postoperative.
Summary of the invention
The object of the invention is the technological deficiency for existing in prior art, and a kind of bioresorbable medical material and preparation method thereof is provided.
The technical scheme adopted for realizing object of the present invention is: a kind of bioresorbable medical material, is characterized in that: it comprises the fabric unit that 2-6 layer superposes mutually, and described fabric unit has several tissue engineering brackets; Described fabric unit is made up of the polyglycolic acid yarn with weft-knitted braiding structure, and described polyglycolic acid yarn comprises 12 polyglycolic acid fibers.
Described fabric unit is tubular-type or sheet type.
Preferably, the danier number of described polyglycolic acid yarn is 25-50D.
Further, the danier number of polyglycolic acid yarn is 28-32D.
Preferably, the diameter of described polyglycolic acid fiber is 15-20um.
A preparation method for bioresorbable medical material, comprises the following steps:
(1) polyglycolic acid material is through melt spinning machine melt spinning, obtains polyglycolic acid yarn after stretching;
(2) polyglycolic acid yarn makes fabric unit by knitting device method;
(3) fabric unit of 2-6 layer is made the bioresorbable medical material of tubular-type or sheet type by PUR pressing.
Preferably, the danier number of described polyglycolic acid yarn is 25-50D.
Further, the danier number of polyglycolic acid yarn is 28-32D.
Preferably, the diameter of described polyglycolic acid fiber is 15-20um.
Compared with prior art, the invention has the beneficial effects as follows:
(1) security performance is high
Polyglycolic acid (PGA) has good biocompatibility, and it in vivo can be degradable and do not need the participation of specific enzymes, and product after degraded can Absorption And Metabolism in body, excretes eventually through urine and breathing; Test proves that polyglycolic acid (PGA) was degraded into carbon dioxide and water at about 15 weeks, can not in longer-term persistence body;
(2) good retractility and ductility
Polyglycolic acid (PGA) material is made fabric unit by knitting device method by the present invention, and it can keep tension force, and reveals good ductility with organ, the motion of tissue and the growth table of cell;
(3) tissue engineering bracket effect is obvious:
Fabric unit provided by the invention has several tissue engineering brackets, can effectively prevent the tissue adhesions such as tendon, blood vessel, spinal column, accelerates wound tissue healing.
Accompanying drawing explanation
Figure 1 shows that the polyglycolic acid yarn scanning electron microscope (SEM) photograph not adopting weft-knitted braiding structure;
Figure 2 shows that the polyglycolic acid yarn scanning electron microscope (SEM) photograph adopting weft-knitted braiding structure;
Figure 3 shows that the scanning electron microscope (SEM) photograph of polyglycolic acid fiber example provided by the invention;
Figure 4 shows that the scanning electron microscope (SEM) photograph of fabric unit pressing PUR pattern used.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment:
A kind of bioresorbable medical material, is characterized in that: it comprises the fabric unit that 2-6 layer superposes mutually, by PUR pressing between the fabric unit of adjacent layer; Described fabric unit is tubular-type or sheet type.Specifically, tubular-type divides endoscopic surgery use to use with open surgery; Sheet type divides sheet type and sheet type.The present invention can be used in organizing the reinforcement of tangent plane or defect to repair: the tissue such as lung, heart, liver, esophagus, gastrointestinal, spleen, pancreas, gallbladder, kidney.
Described fabric unit includes several tissue engineering brackets; Tissue engineering bracket is for supporting the frame material that cells grown is a complete tissue.
Described fabric unit is made up of the polyglycolic acid yarn with weft-knitted braiding structure, and described polyglycolic acid yarn comprises 12 polyglycolic acid fibers.Be illustrated in figure 1 the polyglycolic acid yarn scanning electron microscope (SEM) photograph not adopting weft-knitted braiding structure; Be illustrated in figure 2 the polyglycolic acid yarn scanning electron microscope (SEM) photograph that the present invention adopts weft-knitted braiding structure; In fig. 2, described fabric unit has several tissue engineering brackets.
Preferably, the danier number of described polyglycolic acid yarn is 25-50D.
Further, the danier number of polyglycolic acid yarn is 28-32D.
Danier is the density unit of the direct system of nylon textile fiber, and refer to the quality grams of fiber when official regain that 9000m is long, unit is dawn (D).Such as: 9000m long fibre weighs 600 grams, this fiber is called the fiber of 600D.The long yarn of 9000m weighs 600 grams, and this yarn is called the yarn of 600D.The numerical value at dawn is larger, represents yarn or fiber is thicker.
Preferably, the diameter of described polyglycolic acid fiber is 15-20um.
A preparation method for bioresorbable medical material, comprises the following steps:
(1) polyglycolic acid (PGA) material is through melt spinning machine melt spinning, obtains polyglycolic acid yarn after stretching;
(2) polyglycolic acid yarn makes fabric unit by knitting device method;
(3) fabric unit of 2-6 layer is made the bioresorbable medical material of tubular-type or sheet type by PUR pressing.
Preferably, the danier number of described polyglycolic acid yarn is 25-50D.
Further, the danier number of polyglycolic acid yarn is 28-32D.
Preferably, the diameter of described polyglycolic acid fiber is 15-20um; Be illustrated in figure 3 the scanning electron microscope (SEM) photograph of polyglycolic acid fiber example provided by the invention, the diameter of the polyglycolic acid fiber in Fig. 3 is 15.7um.
The present invention is by 12 fibrous polyglycolic acid yarns of polyglycolic acid (PGA), fabric unit is woven into by weft-knitted weave more again by polyglycolic acid yarn, the fabric unit of 2-6 layer makes bioresorbable medical material by PUR pressing, is illustrated in figure 4 the scanning electron microscope (SEM) photograph of fabric unit pressing PUR pattern used; Apply the present invention to surgical operation, being used for hemorrhage organ or liver as covered, being repaired in vivo and recovering, also can nail processed, blade plate and bone rod; In addition, polyglycolic acid (PGA) fabric unit also can be used for the reparation weaving drug coating or various fire victim.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a bioresorbable medical material, is characterized in that: it comprises the fabric unit that 2-6 layer superposes mutually, and described fabric unit has several tissue engineering brackets; Described fabric unit is made up of the polyglycolic acid yarn with weft-knitted braiding structure, and described polyglycolic acid yarn comprises 12 polyglycolic acid fibers.
2. a kind of bioresorbable medical material according to claim 1, is characterized in that described fabric unit is tubular-type or sheet type.
3. a kind of bioresorbable medical material according to claim 1, is characterized in that the danier number of described polyglycolic acid yarn is 25-50D.
4. a kind of bioresorbable medical material according to claim 1, is characterized in that the danier number of described polyglycolic acid yarn is 28-32D.
5. a kind of bioresorbable medical material according to claim 1, is characterized in that the diameter of described polyglycolic acid fiber is 15-20um.
6. a preparation method for bioresorbable medical material, is characterized in that comprising the following steps:
(1) polyglycolic acid material is through melt spinning machine melt spinning, obtains polyglycolic acid yarn after stretching;
(2) polyglycolic acid yarn makes fabric unit by knitting device method;
(3) fabric unit of 2-6 layer is made bioresorbable medical material by PUR pressing.
7. the preparation method of a kind of bioresorbable medical material according to claim 6, is characterized in that described fabric unit is tubular-type or sheet type.
8. the preparation method of a kind of bioresorbable medical material according to claim 6, is characterized in that the danier number of described polyglycolic acid yarn is 25-50D.
9. the preparation method of a kind of bioresorbable medical material according to claim 6, is characterized in that the danier number of described polyglycolic acid yarn is 28-32D.
10. the preparation method of a kind of bioresorbable medical material according to claim 6, is characterized in that the diameter of described polyglycolic acid fiber is 15-20um.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510527794.1A CN105126174A (en) | 2015-08-26 | 2015-08-26 | Bioabsorbable medical material and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510527794.1A CN105126174A (en) | 2015-08-26 | 2015-08-26 | Bioabsorbable medical material and preparation method thereof |
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| CN105126174A true CN105126174A (en) | 2015-12-09 |
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| CN201510527794.1A Pending CN105126174A (en) | 2015-08-26 | 2015-08-26 | Bioabsorbable medical material and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388139A (en) * | 2020-03-19 | 2020-07-10 | 山东天之祐药业有限公司 | Absorbable repair material for preventing air leakage in operation and preparation method thereof |
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2015
- 2015-08-26 CN CN201510527794.1A patent/CN105126174A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388139A (en) * | 2020-03-19 | 2020-07-10 | 山东天之祐药业有限公司 | Absorbable repair material for preventing air leakage in operation and preparation method thereof |
| CN111388139B (en) * | 2020-03-19 | 2023-09-01 | 山东天之祐药业有限公司 | Absorbable repairing material for preventing air leakage in operation and preparation method |
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Application publication date: 20151209 |