CN105125430A - Sunscreen protection cream containing coenzyme Q10 - Google Patents
Sunscreen protection cream containing coenzyme Q10 Download PDFInfo
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- CN105125430A CN105125430A CN201510430436.9A CN201510430436A CN105125430A CN 105125430 A CN105125430 A CN 105125430A CN 201510430436 A CN201510430436 A CN 201510430436A CN 105125430 A CN105125430 A CN 105125430A
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Abstract
The invention relates to a group of preparations composed of five natural antioxidant ingredients namely coenzyme Q10, lipoic acid, glycyrrhizic acid, vitamin E and vitamin C and having the effects of blocking sunlight and repairing skin injury caused by ultraviolet; the preparations comprise cream and emulsion; the preparations have a strong absorption effect on ultraviolet UVC, UVB and UVA, especially have a stable absorption effect in the range of 290nm-320nm, and meanwhile, the preparations have a strong repairing effects on skin cell injury comprising DNA injury caused by ultraviolet irradiation. The group of preparations can be prepared into cream or emulsion according to a conventional cosmetic process, can be used as a skin care product for resisting light aging and skin aging daily and also can be used as a sunscreen product prepared from purely natural ingredients. Physical or chemical sunscreen ingredients are added into the preparations, so that the effect is better when the preparations are used as sunscreen protection cream.
Description
Technical field
The present invention relates to one group of protection skin from ultraviolet photoaging effect, repair the skin injury of photoaging, the formula and processing technology containing the sun-proof maintenance frost of coenzyme Q10 of the aging of delaying skin, belong to external-use skin care preparation and cosmetic technical field.
Background technology
Due to the high speed development of modern industry and to the reasonably protection of environment shortage; modern industry pollutant are day by day serious to the pollution of environment; in addition; because sunlight irradiates; ultraviolet Large Amount of Irradiated, too much UV contact is the main cause causing a series of diseases such as skin photoage, skin canceration, immunosuppressant.Ultraviolet radiation can produce the oxygen-derived free radicals of high response, skin antioxidant system can be made again (to comprise ubiquinone simultaneously
10) suffer loss.In the skin Natural antioxidant, ubiquinone
10, thioctic acid, vitamin C and vitamin E are important component known at present, with age and ultraviolet radiation increase, ubiquinone in skin
10content Deng antioxidant reduces gradually, therefore, if supplement natural antioxidant to skin will contribute to protection skin from ultraviolet photoaging effect, repairs the skin injury of photoaging, the aging of delaying skin.
Solar radiation refers to the Electromagnetic Continuous radiation arriving earth surface, and comprise some ultra violet rays and visible ray, wherein visible wavelength is 400nm ~ 800nm, and ultraviolet wavelength is 200nm ~ 400nm.Ultraviolet is divided into short wave ultraviolet (UVC, 200nm ~ 280nm), ultraviolet B radiation (UVB, 280nm ~ 320nm) and long wave ultraviolet (UVA, 320nm ~ 400nm) by department of dermatologry educational circles.In ultraviolet and visible light, wavelength is longer, and penetration power is stronger; Wavelength is shorter, and energy is stronger, more easily causes dermatosis.Wherein UVC is the strongest to the kill capability of life cells, but substantially by the oxygen in surface air layer and ozone absorb.Therefore, arrive ultraviolet mainly UVA and VUB on ground, so UVA and UVB is the principal action spectra causing skin injury, UVB only involves epidermis, and UVA and visible ray have the greatest impact to corium.Ultraviolet in sunlight can kill or suppress the antibacterial of skin surface, appropriate ultraviolet radiation can promote that the dehydrocholesterol in skin is converted into vitamin D3, strengthen irritability and the stress ability of sympathetic nerve-adrenal system, strengthen body immunity, promote some hormone secretion in body, the growth promoter of human body is played an important role.But ultraviolet excessive radiation also can produce detrimental effect to human body.Ultraviolet can produce the machining functions such as free radical in body cell by coup injury DNA or induced oxidation reaction, causes the increase of cell mutation frequency, cell cycle arrest, apoptosis occur or promote cell proliferation, can also cause the generation of skin carcinoma.IARC has confirmed that ultraviolet radiation is a cancerigenic factor completely, and it can cause sudden change, can cause again inspiring and growth promoting effect cancerous cell.The generation of ultraviolet radiation and application on human skin malignant melanoma, basal cell carcinoma and squamous cell carcinoma is closely related to have enough evidences to show.
Ultraviolet is to the damage of skin, one of topmost reason is exactly that free radical produces, UVA causes that cell free radical produces, the ability of lipid peroxidation is the strongest, the collagen in dermal tissue and elastic fibers can be affected, produce skin photoage, UVB mainly causes the pathological changes of epidermal area and high dermis, and producing sunburn, immunosuppressant and skin carcinoma, is the main wave band causing skin carcinoma; In addition UVB directly acts on DNA and produces pyrimidine dimer (CPD) and 6-4 photoproduct, when UVB irradiate the freeradical yield brought out exceed the removing limit of purge mechanism time, there is the accumulation of free radical, these free radicals are mainly oxygen-derived free radicals, the oxygen-derived free radicals of high concentration can cause DNA damage, cause change or the producer sudden change of related gene expression level, the oxygen-derived free radicals of low concentration starts the cell signaling processes after ultraviolet radiation mainly as second message,second messenger, and this is very important in photoaging mechanism.When after UVB damage dna, body can produce cell cycle arrest makes cell cycle progression lull carry out the reparation damaged.
In skin, silicosis oxidant and anti-oxidant system unbalance is the major reason of light loss evil, due to acute and be exposed to sunlight for a long time, and, produce a large amount of free radicals in skin, as active oxygen (ROS) etc.The object that much potential site is damaged as free-radical oxidation is had in skin layers.These sites comprise lipid, protein and DNA.ROS inspires lipid, the peroxidating of protein and the damage of DNA.The disappearance for being positioned at 4977 base pairs that sudden change as mitochondrial DNA is the most common, obviously increases in the skin of photoaging.Common disappearance in normal human fibroblast and UVA open-assembly time and dosage are proportionate.Above-mentioned infringement all will cause skin generation pathologic to change.On the other hand, skin is under long-term endogenous and ectogenic oxidative pressure, can form powerful antioxidant system, this system forms primarily of two parts: antioxidase and low molecule antioxidant, and the former comprises multiple hydrolytic enzyme, superoxide dismutase, glutathion peroxidase etc.; The latter is mainly vitamin E, vitamin C, coenzyme Q10 etc.If ROS flows exceed the regeneration of antioxidant in skin, then occur uneven between oxidant and antioxidant, the redox state of cell is to the transfer of oxidation side, and now isotope of redox-sensitive signal transduction pathway and corresponding gene up-regulated, causes the pathological process of skin light loss evil.
The difference due to dosage and persistent period is penetrated in illumination, and the impact produced the antioxidant system in skin is different.The illumination of larger dose in a short time, makes the antioxidant system in skin be subject to obvious destruction, produces acute light loss evil.Such as accept 10 times of minimum erythema dose UV to irradiate, in skin, above-mentioned 4 kinds of main antioxidant enzymes and antioxidant all obviously decline.The light loss evil of chronic sustained can make skin antioxidant system produce complicated adaptive change.In the epidermis of photoaging, catalase activity is 163% of normal epidermis, and activity is then 67% of normal skin in the dermis.In the epidermis of photoaging, the content of vitamin E is only 56% of normal human skin, and the content of vitamin E change in corium is not obvious.And ascorbic content content in the epidermis and corium of photoaging is respectively 69% and 63% of normal skin content.Therefore for outer also by additionally supplementing antioxidant to block the oxidative damage of free radical mediated with the light absorption of blocking skin except using opacifier in the control strategy of light loss evil, thus reach and delay or pathophysiological process that blocking light damages.
Coenzyme Q10 is also widely distributed in human body, and the content in epiderm skin is 7.66nmol/g, and the content in corium is 3.15nmol/g; 90% exists with the form of oxidation in the dermis, and only has 55% in epidermis.It is the main cause producing photoaging that the content of endogenic antioxidant coenzyme Q10 reduces, and as local topical coenzyme Q10, can penetrate epidermal area, subtract the oxidative damage of skin clearly, wrinkle of skin shoals.Coenzyme Q10 has significant protective effect to the Human Keratinocytes oxidative stress that UVA mediates, and it can remove mercaptan, activates the DNA damage that specificity phosphate tyrosine kinase blocking oxide cause.Coenzyme Q10 also significantly can suppress the expression of human skin fibroblast hose lining Clotogen thus reduce the degraded of collagen in skin.Therefore, the many-side that its photoaging capable of blocking causes is damaged.Coenzyme Q10 is hydrogen carrier important in Cellular respiration chain, participates in the process of cellular oxidation phosphorylation, can accelerate the generation of ATP, and strengthening cellular energy metabolism, is the indispensable composition of life.In addition, due to the characteristic of its electron transmission, determining it is the good free radical inhibitors of a class, can protect the integrity of biofilm structure.The number of human body coenzyme Q10 content and the generation of a lot of disease, develop all directly or indirectly relevant, the level of body coenzyme Q 10 and the generation of ROS are negative correlation, when coenzyme Q10 level drops to 30% ~ 50% of normal value, the generation of its content and ROS increases and there is dependency with cell death, the inflammatory reaction that coenzyme Q10 can make UV or interleukin (IL) 1 induce is inhibited, the generation of PGE2,1L-6 and MMP-1 tri-kinds of inflammatory factors reduces, thus prevents the degraded of skin corium extracellular matrix.The oxidative stress of coenzyme Q10 to the Human keratinocytes that UVA mediates has significant protective effect, with its removing mercaptan, activates the DNA damage that specificity phosphate tyrosine kinase blocking oxide cause and is correlated with; Coenzyme Q10 significantly can suppress the expression of human skin fibroblast hose lining Clotogen in addition, thus reduces the degraded of collagen in skin, and describing coenzyme Q10 can as antioxidant for alleviating the damaging action of skin photoage.In addition, the coenzyme Q10 content of skin reduces gradually with advancing age, skin surface cortex antioxidation just obviously reduce.It is reported that coenzyme Q10 and vitamin E are only antioxidant in skin surface lipid; although content is lower; but the minimizing of Trionyx sinensis Wiegmann alkene, cholesterol and unsaturated fatty acid in the cortex lipid that they can significantly suppress ultraviolet radiation to cause, and the minimizing of these compositions can reduce the protective effect of outermost layer cortex to skin.Therefore, in the sebum of human body, epidermis and corium, all play a part antioxidation anti-aging for coenzyme Q10.
Alpha-lipoic acid is as a kind of Natural antioxidant, and recently caused and paid close attention to widely, thioctic acid belongs to vitamin(e) B group compound, works in the multienzyme complexs such as pyruvic dehydrogenase, ketoglurate dehydrogenase, aminocaproic acid decarboxylase as coenzyme.Thioctic acid has oxidized form (LA) and reduced form (DHLA), relative molecular mass is larger than water soluble ascorbic acid, but it is less than fatsoluble vitamin E, therefore it not only had water solublity but also tool fat-soluble, the Suo Ji of its molecule terminal makes it have more water solublity than VE, meanwhile, it contains more carbon atom than AsA, and thus comparatively AsA is more soluble in film fat.Sulfur-bearing, the single-stranded structure compound of carbon atom, such as oxidized form of glutathione (GSSG), oxidized type dehydroascorbic acid (DHA), cystine etc. do not possess non-oxidizability, but LA has sulfur, the closed circular molecular structure that carbon atom is formed, electron density is very high, therefore it has non-oxidizability, can direct Scavenger of ROS, the thioctic acid of oxidized form and reduced form can remove single chloric acid, hydrogen peroxide, superoxide anion nitrous acid, hydroxyl, peroxide radical isoreactivity oxygen, but, only have oxidized form thioctic acid can remove single line condition oxygen, reduced form thioctic acid then the many antioxidants of reducible regeneration as ascorbic acid, vitamin E, glutathion, coenzyme Q10, thioredoxin etc.The oxidoreduction of the thioctic acid of oxidized form and reduced form have activated the metabolic cycles of other antioxidants in organism, forms unique biological anti-oxidant regeneration cycle network, maintains the normal antioxidant level of body, jointly play biological antioxidant effect.
Vitamin E has good protective effect to light loss evil; vitamin E is the non-enzyme antioxidant of the topmost lipophilic in human body; wherein the highest with alpha-tocopherol content; in epidermis, content is 31nmol/g; be 16nmol/g in corium; than low many in other non-exposed tissue, intraepidermal vitamin E is from outside to inside in progressively increasing trend.Ultraviolet can reduce the content of vitamin E in horny layer, and the mechanism that vitamin E plays photoprotection is by raising body antioxidant system.After local topical vitamin E, epidermis and intradermal 4 kinds of antioxidase content have increase in various degree, and ascorbic content too increases, and lipid peroxide then significantly reduces.Vitamin E also may be by direct antioxidation and the mechanisms play photoprotection indirectly thickening epidermis.Mice external vitamin E, gives UVB and irradiates after one week, tissue pathology checking's display vitamin E treatment group thickens with parakeratosis than matched group epidermis, photic damage Leukopenia.Vitamin E also has protective effect to cellular metabolism.It can make cellular pH keep stable, and maintain glutathione level and transmembrane potential, and can increase the survival ability of cell, human body fibroblast produces a large amount of free radicals after being exposed to UVB, and vitamin E can provide strong protective effect.Vitamin E, also by the activity of Profilin kinase c, reduces the expression of collagenase, suppresses collagen degradation, improves aging sign.
Vitamin C is water miscible antioxidant, and content is in skin 0.4 ~ 1mg/100g wet tissue, and the content in people's epidermis is 3.8 μm of ol/g, higher than the content of 0.7 μm of ol/g in corium.Vitamin C can deactivation list oxygen, superoxides, hydrogen peroxide and Watersoluble peroxygen free radical effectively.Vitamin C can also make the vitamin E of oxidation reduce and vitamin E is regenerated.External vitamin C can be less readily available for absorption by the skin, and the Vitamin C content in skin is raised.After taking vitamin C 50d continuously, in keratinocyte, Vitamin C content improves, but without photoprotection, takes if combine with vitamin E, and in keratinocyte, vitamin E and ascorbic content all improve, and show good photoprotection.Vitamin C can raise fra-1 gene, and then lower the target gene of Activated protein-1 (AP-1), vitamin C also suppresses the activity of the phosphorylation of endogenic c-Jun albumen and then reduction Activated protein-1 to resist primary cellular defect and the death of ultraviolet induction by the phosphorylation of prevention c-Jun N-terminal kinase (JNK) and the activation of this enzyme.Because vitamin C is very easily oxidized, topical application is made to be subject to a definite limitation.Synthesized the derivant of multivitamin C in recent years by chemical method, as carried out acyl group to vitamin C, make its stable in properties, dissolubility is good, and local topical has shown and has good efficacy.
Glycyrrhizic acid and glycyrrhizin are the main components of Radix Glycyrrhizae, have antiinflammatory, antioxygen, antibacterial, treatment wound, the effect of effectively removing superoxide ion and hydroxyl radical free radical, significantly suppressing liposome peroxidation thing.Glycyrrhizic acid has compatibility widely in cosmetics, and normal and other activating agents share, and can accelerate skin potentiation to their absorption, can be used for sun-proof, brighten, nurse one's health, antipruritic and hair-growing and hair care etc.
Sun care preparations is all containing sunscreen actives, and these compositions can be divided into two large classes: physical property screener and chemical absorbent.Physical property screener (as titanium dioxide, zinc oxide, titanium oxide etc.) mainly utilizes some inorganic matter and novel organic powder to ultraviolet scattering or reflection to reduce the infringement of ultraviolet to skin.Chemical absorbent is then material ultraviolet to absorption, and conventional has para-amino benzoic acid and derivant, salicylate and derivant thereof, cinnamate and derivant, Benzophenones compound, camphor derivative, benzimidazole class and derivant, triazines and derivant thereof, dibenzoyl methane analog derivative etc.Our research finds, the sun-proof maintenance frost be made up of coenzyme Q10, thioctic acid, vitamin E, vitamin C and glycyrrhizic acid, there is comparatively ideal sun-proof result, all have higher absorption value to ultraviolet light absorption angle value at 280 ~ 320nm wavelength, and level state after presenting first increasing.We are configured with three kinds of formula and detect, three kinds of formula all show and well absorb ultraviolet effect, the spf value of three kinds of coenzyme Q10 formula of sun screen reaches 10 respectively, 20, 27, because these three kinds of compositions are all antioxidants, the skin injury that the oxidative stress caused ultraviolet causes also has further to be repaired, maintenance action, therefore, with coenzyme Q10, five kinds of one-tenth such as thioctic acid are grouped into a kind of novel sunscreen cream with absorption action of ultraviolet radiation preferably, not only there is uvioresistant to the damaging action of skin, and to being caused the Skin Cell damaged also to have reparation and maintenance action by ultraviolet radiation.
Summary of the invention
The present invention proposes one group by coenzyme Q10, thioctic acid, glycyrrhizic acid, what the five kinds of Natural antioxidants of vitamin E and vitamin C became to be grouped into have sun-proof with reparation ultraviolet to the preparation of skin injury, comprise cream and Emulsion, this preparation all has strong Absorption to ultraviolet (UV) C, UVB and UVA, within the scope of 290nm ~ 320nm, particularly there is stable strong Absorption, meanwhile, to the Skin Cell damage that ultraviolet radiation has produced, comprise DNA damage, also have powerful repair.This preparation, can be prepared into cream or Emulsion by cosmetic technology conveniently, wherein, the percentage composition of these five kinds of compositions is coenzyme Q10s 0.5 ~ 3.0%: thioctic acid 0.1 ~ 2.0%: glycyrrhizic acid 0.5 ~ 3.0%, vitamin E 0.5 ~ 3.0%, vitamin C 0.1 ~ 1.0%.
When preparing maintenance frost sun-proof containing coenzyme Q10, wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0 grams, thioctic acid 0.3 gram, glycyrrhizic acid 1.0 grams, vitamin e1 .0 gram, vitamin C 0.3 gram; Wherein, the glycyrrhizic acid in this formula can use Radix Glycyrrhizae extract, enoxolone, disodium glycyrrhizinate, and glycyrrhizic acid dipotassium replaces.
When preparing containing coenzyme Q10 sun-proof maintenance frost, this preparation can also increase plant sun agent, as Radix Ginseng, and the Radix Astragali, Radix Scutellariae, Aloe, Herba Cistanches, Rhizoma Kaempferiae, Rhizoma Curcumae Longae etc., and the extract of these Chinese medicines and effective ingredient.
When preparing maintenance frost sun-proof containing coenzyme Q10, this preparation can also increase physics sunscreen as titanium dioxide, zinc oxide etc.; Chemical sun (1) para-amino benzoic acid and derivant thereof can also be increased, as PABA Octyl Nitrite, PEG-25 para-amino benzoic acid etc.; (2) salicylate and derivant, as ethylhexyl salicylate, heliophan, ethylhexyl salicylate, phenyl salicytate, the different hexadecyl ester of salicylic acid, salicylic acid hexyl ten diester, dipropylene glycol salicylate, benzyl salicylate etc.; (3) cinnamate derivative is as ethylhexyl methoxy cinnamate, Octyl methoxycinnamate, iso-amyl p-methoxycinnamate, p-methoxycinnamic acid ethanolamine salt etc.; (4) hexichol (first) ketone is as ESCALOL 567,2-hydroxyl-4-methoxybenzene diketone-5-sulfonic acid etc.; (5) o-aminobenzoa and derivant thereof are as methyl 2-aminobenzoate, the own ester of N-acetyl ortho-aminobenzoic acid trimethyl, ortho-aminobenzoic acid menthol ester, ortho-aminobenzoic acid height menthol ester etc.; (6) camphor derivative such as 4 methyl benzylidene camphor, Unisol S-22, benzylidene camphor sulfonic acid, Camphora benzene pricks ammonium methyl sulphate, polyacrylamide methyl benzylidene camphor, Terephthalidene Dicamphor Sulfonic Acid etc.; (7) dibenzoyl methane class is as Parsol 1789,4-isopropyl dibenzoyl methane, 4,4-methoxy dibenzoyl methanes, the 4-tert-butyl group-2 '-hydroxy benzophenone acyl methane, the 4-tert-butyl group-2 '-hydroxyl-4 '-methoxy dibenzoyl methane etc.
For achieving the above object, the present invention can the preparation technology of cream traditionally and Emulsion produce, and adopts following technical scheme:
Detailed description of the invention:
Below specific embodiments of the invention; technical scheme of the present invention is done and describes further; but protection scope of the present invention is not limited to these embodiments, every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment one
Ubiquinone
10the formula components (100 grams) of sun-proof maintenance frost (1): ubiquinone
100.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (1): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
At the above-mentioned ubiquinone of preparation
10time sun-proof maintenance frost (1), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; Wherein, the glycyrrhizic acid in this formula can use Radix Glycyrrhizae extract, enoxolone, disodium glycyrrhizinate, and glycyrrhizic acid dipotassium replaces.
Embodiment two
Ubiquinone
10the formula components (100 grams) of sun-proof maintenance frost (2): ubiquinone
100.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, ginsengenin 20 .1 ~ 1.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (2): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, ginsenoside, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
At the above-mentioned ubiquinone of preparation
10time sun-proof maintenance frost (2), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%, wherein, the ginsenoside that this formula adds can use Radix Ginseng extract, stem and leaf of Radix Ginseng saponin, and Flos Ginseng's saponin replaces.
Embodiment three
Ubiquinone
10the formula components (100 grams) of sun-proof maintenance frost (3): ubiquinone
100.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, titanium dioxide 2.0 ~ 20.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (3): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, titanium dioxide, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
At the above-mentioned ubiquinone of preparation
10time sun-proof maintenance frost (3), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; The titanium dioxide that this formula adds can use nano titanium oxide, nano zine oxide or zinc oxide to replace.
Embodiment four
Ubiquinone
10the formula components (100 grams) of sun-proof maintenance frost (4): ubiquinone
100.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, ethylhexyl methoxy cinnamate 5.0 ~ 8.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (4): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, ethylhexyl methoxy cinnamate, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
At the above-mentioned ubiquinone of preparation
10time sun-proof maintenance frost (4), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; The ethylhexyl methoxy cinnamate that this formula adds can use Octyl methoxycinnamate, iso-amyl p-methoxycinnamate, p-methoxycinnamic acid ethanolamine salt to replace.
Embodiment five
The formula components (100 grams) of the sun-proof maintenance frost (5) of coenzyme Q10: coenzyme Q10 0.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, ESCALOL 567 1.0 ~ 5.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (5): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, ESCALOL 567, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
At the above-mentioned ubiquinone of preparation
10time sun-proof maintenance frost (5), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; The ESCALOL 567 that this formula adds can use the replacements such as 2-hydroxyl-4-methoxybenzene diketone-5-sulfonic acid.
Embodiment six
The formula components (100 grams) of the sun-proof maintenance frost (6) of coenzyme Q10: coenzyme Q10 0.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, PEG-25 para-amino benzoic acid 1.0 ~ 5.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (6): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, PEG-25 para-amino benzoic acid, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
At the above-mentioned ubiquinone of preparation
10time sun-proof maintenance frost (6), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; The PEG-25 para-amino benzoic acid that this formula adds can use the replacements such as PABA Octyl Nitrite, para-amino benzoic acid.
Embodiment seven
The formula components (100 grams) of the sun-proof maintenance frost (7) of coenzyme Q10: coenzyme Q10 0.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, butyl methoxydibenzoylmethise 1.0 ~ 5.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (7): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, butyl methoxydibenzoylmethise, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
At the above-mentioned ubiquinone of preparation
10time sun-proof maintenance frost (7), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing ubiquinone
101.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; The butyl methoxydibenzoylmethise that this formula adds can use 4-isopropyl dibenzoyl methane, 4,4-methoxy dibenzoyl methanes, the 4-tert-butyl group-2 '-hydroxy benzophenone acyl methane, the 4-tert-butyl group-2 '-hydroxyl-4 ' replacement such as-methoxy dibenzoyl methane.
Embodiment 8
The formula components (100 grams) of the sun-proof maintenance frost (8) of coenzyme Q10: coenzyme Q10 0.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, ethylhexyl salicylate 1.0 ~ 5.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml;
Ubiquinone
10the compound method of sun-proof maintenance frost (8): (1) takes the ubiquinone of recipe quantity
10, thioctic acid, glycyrrhizic acid, ethylhexyl salicylate, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C; (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase; (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
When preparing above-mentioned coenzyme Q10 sun-proof maintenance frost (8), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts contain coenzyme Q10 1.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; The ethylhexyl salicylate that this formula adds can use heliophan, ethylhexyl salicylate, phenyl salicytate, the different hexadecyl ester of salicylic acid, salicylic acid hexyl ten diester, dipropylene glycol salicylate, benzyl salicylate etc. to replace.
Claims (13)
1. one kind containing coenzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that in the formula of this cream containing coenzyme Q10, thioctic acid, glycyrrhizic acid, the five kinds of Natural antioxidants of vitamin E and vitamin C become to be grouped into, cosmetic technology is conveniently prepared into cream or Emulsion, wherein, the percentage composition of these five kinds of compositions is coenzyme Q10s 0.5 ~ 3.0%: thioctic acid 0.1 ~ 2.0%: glycyrrhizic acid 0.5 ~ 3.0%, vitamin E 0.5 ~ 3.0%, vitamin C 0.1 ~ 1.0%.
2. a kind of sun-proof white with the sun-proof maintenance of reparation ultraviolet to skin injury containing having of enzyme Q10 as claimed in claim 1, it is characterized in that the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing coenzyme Q10 1.0 grams, thioctic acid 0.3 gram, glycyrrhizic acid 1.0 grams, vitamin e1 .0 gram, vitamin C 0.3 gram.
3. a kind of sun-proof white with the sun-proof maintenance of reparation ultraviolet to skin injury containing having of enzyme Q10 as claimed in claim 1, it is characterized in that when preparing maintenance frost sun-proof containing coenzyme Q10, this preparation can also increase plant sun agent, as Radix Ginseng, and the Radix Astragali, Radix Scutellariae, Aloe, Herba Cistanches, Rhizoma Kaempferiae, Rhizoma Curcumae Longae, and the extract of these Chinese medicines and effective ingredient.
4. a kind of sun-proof white with the sun-proof maintenance of reparation ultraviolet to skin injury containing having of enzyme Q10 as claimed in claim 1, it is characterized in that this preparation can increase physics sunscreen as titanium dioxide, zinc oxide when preparing maintenance frost sun-proof containing coenzyme Q10; Chemical sun (1) para-amino benzoic acid and derivant thereof can also be increased, as PABA Octyl Nitrite, PEG-25 para-amino benzoic acid; (2) salicylate and derivant, as ethylhexyl salicylate, heliophan, ethylhexyl salicylate, phenyl salicytate, the different hexadecyl ester of salicylic acid, salicylic acid hexyl ten diester, dipropylene glycol salicylate, benzyl salicylate; (3) cinnamate derivative is as ethylhexyl methoxy cinnamate, Octyl methoxycinnamate, iso-amyl p-methoxycinnamate, p-methoxycinnamic acid ethanolamine salt; (4) hexichol (first) ketone is as ESCALOL 567,2-hydroxyl-4-methoxybenzene diketone-5-sulfonic acid; (5) o-aminobenzoa and derivant thereof are as methyl 2-aminobenzoate, the own ester of N-acetyl ortho-aminobenzoic acid trimethyl, ortho-aminobenzoic acid menthol ester, ortho-aminobenzoic acid height menthol ester; (6) camphor derivative such as 4 methyl benzylidene camphor, Unisol S-22, benzylidene camphor sulfonic acid, Camphora benzene pricks ammonium methyl sulphate, polyacrylamide methyl benzylidene camphor, Terephthalidene Dicamphor Sulfonic Acid; (7) dibenzoyl methane class is as Parsol 1789,4-isopropyl dibenzoyl methane, 4,4-methoxy dibenzoyl methanes, the 4-tert-butyl group-2 '-hydroxy benzophenone acyl methane, the 4-tert-butyl group-2 '-hydroxyl-4 '-methoxy dibenzoyl methane.
5. as claim 1, described in 2 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, the formula components that it is characterized in that the sun-proof maintenance frost (1) of coenzyme Q10 is (100 grams): coenzyme Q10 0.3 ~ 3.0, thioctic acid 0.1 ~ 2.0, glycyrrhizic acid 0.5 ~ 3.0, vitamin E 0.5 ~ 3, vitamin C 0.1 ~ 1.0, mineral oil 6 ~ 12, lanoline 10.0 ~ 15.0, stearic acid 3.0 ~ 4.5, spermaceti 5.4 ~ 6.5, spermol 10.0 ~ 12.0, triethanolamine 8.0 ~ 10.0, ethyl hydroxybenzoate 0.1 ~ 0.2, essence is appropriate, deionized water 30 ~ 40.0ml, compound method is: (1) takes the coenzyme Q10 of recipe quantity, thioctic acid, glycyrrhizic acid, mineral oil, lanoline, stearic acid, spermaceti, spermol, mixed melting to 80 DEG C, (2) separately get triethanolamine, ethyl hydroxybenzoate and deionized water heating for dissolving to 80 DEG C and obtain aqueous phase, (3) slowly added in aqueous phase by oil phase, limit edged stirs.Less than (4) 45 DEG C to add vitamin C and essence appropriate, lets cool and get final product.
6. as claim 1, described in 2 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing above-mentioned coenzyme Q10 sun-proof maintenance frost (1), wherein the optimum amount of sun-proof maintenance composition is that every 100 grams of frosts are containing coenzyme Q10 1.0%, thioctic acid 0.3%, glycyrrhizic acid 1.0%, vitamin e1 .0%, vitamin C 0.3%; Wherein, the glycyrrhizic acid in this formula can use Radix Glycyrrhizae extract, enoxolone, disodium glycyrrhizinate, and glycyrrhizic acid dipotassium replaces.
7. as claim 1,2,3, described in 5 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing coenzyme Q10 sun-proof maintenance frost (2), wherein sun-proof maintenance composition with the addition of ginsengenin 20 .1 ~ 1.0.
8. as claim 1,2,4, described in 5 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing coenzyme Q10 sun-proof maintenance frost (3), wherein sun-prevention component with the addition of titanium dioxide 2.0 ~ 20.0.
9. as claim 1,2,4, described in 5 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing coenzyme Q10 sun-proof maintenance frost (4), wherein sun-prevention component with the addition of ethylhexyl methoxy cinnamate 5.0 ~ 8.0.
10. as claim 1,2,4, described in 5 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing coenzyme Q10 sun-proof maintenance frost (5), wherein sun-prevention component with the addition of ESCALOL 567 1.0 ~ 5.0.
11. as claim 1,2,4, described in 5 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing coenzyme Q10 sun-proof maintenance frost (6), wherein sun-prevention component with the addition of PEG-25 para-amino benzoic acid 1.0 ~ 5.0.
12. as claim 1,2,4, described in 5 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing coenzyme Q10 sun-proof maintenance frost (7), wherein sun-prevention component with the addition of butyl methoxydibenzoylmethise 1.0 ~ 5.0.
13. as claim 1,2,4, described in 5 a kind of containing enzyme Q10 have sun-proof with repair the sun-proof maintenance frost of ultraviolet to skin injury, it is characterized in that when preparing coenzyme Q10 sun-proof maintenance frost (8), wherein sun-prevention component with the addition of ethylhexyl salicylate 1.0 ~ 5.0.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3369413A1 (en) * | 2017-03-01 | 2018-09-05 | The Boots Company PLC | Cosmetic skincare compositions |
| CN110742818A (en) * | 2019-09-17 | 2020-02-04 | 广东润和生物科技有限公司 | Preparation method of coenzyme Q10 liposome capable of resisting ultraviolet injury |
| CN111514075A (en) * | 2020-06-03 | 2020-08-11 | 北京斯利安药业有限公司 | Sunscreen composition and application thereof |
| CN112057363A (en) * | 2019-06-11 | 2020-12-11 | 青岛大学附属医院 | Sunscreen cream |
| CN114848536A (en) * | 2022-05-13 | 2022-08-05 | 上海好肌茵生物科技有限公司 | Skin photodamage repairing composition, preparation method and application thereof |
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| CN101664372A (en) * | 2009-10-12 | 2010-03-10 | 董萍 | Antioxidant network efficacy nanoemulsion externally used for skin and preparation method thereof |
| CN101849890A (en) * | 2010-05-18 | 2010-10-06 | 董萍 | Synchronous repair and sunscreen composite nano emulsion for skin injury from ultraviolet A radiation and ultraviolet B radiation and method for preparing same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101664372A (en) * | 2009-10-12 | 2010-03-10 | 董萍 | Antioxidant network efficacy nanoemulsion externally used for skin and preparation method thereof |
| CN101849890A (en) * | 2010-05-18 | 2010-10-06 | 董萍 | Synchronous repair and sunscreen composite nano emulsion for skin injury from ultraviolet A radiation and ultraviolet B radiation and method for preparing same |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3369413A1 (en) * | 2017-03-01 | 2018-09-05 | The Boots Company PLC | Cosmetic skincare compositions |
| WO2018171943A1 (en) * | 2017-03-01 | 2018-09-27 | The Boots Company Plc | Cosmetic skincare compositions |
| AU2018239198B2 (en) * | 2017-03-01 | 2021-02-04 | The Boots Company Plc | Cosmetic skincare compositions |
| US11285090B2 (en) | 2017-03-01 | 2022-03-29 | The Boots Company Plc | Cosmetic skincare compositions |
| CN112057363A (en) * | 2019-06-11 | 2020-12-11 | 青岛大学附属医院 | Sunscreen cream |
| CN110742818A (en) * | 2019-09-17 | 2020-02-04 | 广东润和生物科技有限公司 | Preparation method of coenzyme Q10 liposome capable of resisting ultraviolet injury |
| CN111514075A (en) * | 2020-06-03 | 2020-08-11 | 北京斯利安药业有限公司 | Sunscreen composition and application thereof |
| CN111514075B (en) * | 2020-06-03 | 2022-12-13 | 北京斯利安药业有限公司 | Sunscreen composition and application thereof |
| CN114848536A (en) * | 2022-05-13 | 2022-08-05 | 上海好肌茵生物科技有限公司 | Skin photodamage repairing composition, preparation method and application thereof |
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