CN105120776A - Thrombectomy catheter - Google Patents
Thrombectomy catheter Download PDFInfo
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- CN105120776A CN105120776A CN201480020975.9A CN201480020975A CN105120776A CN 105120776 A CN105120776 A CN 105120776A CN 201480020975 A CN201480020975 A CN 201480020975A CN 105120776 A CN105120776 A CN 105120776A
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- suction chamber
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Abstract
A thrombectomy catheter includes a catheter body extending from a catheter proximal portion to a catheter distal portion and including a catheter intermediate portion, the catheter body includes an aspiration lumen and an infusion lumen extending along the catheter body, wherein the aspiration lumen includes an aspiration orifice open at a distal end of the catheter body.
Description
Technical field
Medical apparatus is thrombectomy catheter and method in particular.
Background technology
Thrombectomy is a kind of therapy being used for removing from the blood vessel of such as tremulous pulse or vein clot (thrombosis).If thrombosis is not removed, can plug flow.Implementing a technology of thrombectomy is use the conduit with spray chamber and suction chamber, and described spray chamber is used for smashing thrombosis, and described suction chamber is used for vacuum absorption thrombosis and embolus.
In some instances, use complicated conduit system to perform thrombectomy operation, configure described system to provide multiply high-pressure spray, described jet can be the saline with 10,000psi or the supply of larger pressure.Correspondingly, supply high-pressure fluid and need high-pressure pump.For other medical care precesses, the pump practicality of high pressure thrombectomy operation (such as, medicine and radiography injection etc.) is not strong.
In addition, the complicated manifold, fluid jet exhaust characteristic etc. the thrombectomy catheter structure in these operations with the fluid jet removing thrombosis for distribution from blood vessel is used in.In addition, in order to can carry and distribute high-pressure fluid, these conduits are constructed with robust material.Correspondingly, these thrombectomy system expensive, need the manufacturing technology of multi-step, and need special operating equipment (such as, high-pressure pump) as described above further.
Summary of the invention
An example of the present disclosure comprises catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, described catheter body comprises the suction chamber and filling cavity that extend along it, and wherein said suction chamber comprises the suction socket of opening at described catheter body far-end.
In another example of the present disclosure, described catheter body has overall uniform cross-sectional profiles, and there are the multiple hardness numbers varied along its length, make mutually relatively under, described proximal catheter end portion has relatively high hardness number, and described distal catheter portion has relatively low hardness number.
Or in another example of the present disclosure, described filling cavity extends along described catheter body towards described distal portions, and comprise the single fill orifice configuring and be used for guiding fluid jet to penetrate from the longitudinal axis radial direction of described catheter body.
Or in another example of the present disclosure, the far-end of catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends and has the opening similar with described suction chamber size from the far-end of described catheter body, and described distal portions has the opening wider than described suction chamber.
In a specific example, disclose a kind of thrombectomy catheter, comprise the catheter body extending to distal catheter portion from proximal catheter end portion; From described proximal catheter end portion towards described distal catheter portion through the suction chamber that described catheter body extends, described suction chamber comprises suction socket near described distal catheter portion, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends and has the opening similar with described suction chamber size from the far-end of described catheter body, and described distal portions has the opening wider than described suction chamber; And along the filling cavity that described catheter body distally partly extends, described filling cavity has the single fill orifice being positioned at described catheter body sidewall, described single fill orifice configuration is used for guiding fluid jet to penetrate from the longitudinal axis radial direction of described catheter body.
A kind of thrombectomy catheter is disclosed in another specific example, comprise catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, catheter body comprises the suction chamber and filling cavity that extend along it, described catheter body has overall uniform cross-sectional profiles, and there are the multiple hardness numbers varied along its length, make mutually relatively under, described proximal catheter end portion has relatively high hardness number, and described distal catheter portion has relatively low hardness number; Wherein said suction chamber comprises the suction socket of opening at described catheter body far-end; And wherein said filling cavity extends along described catheter body towards described distal portions, and comprise the single fill orifice configuring and be used for guiding fluid jet to penetrate from the longitudinal axis radial direction of described catheter body.
A kind of thrombectomy catheter is disclosed in another specific example, comprise catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, under wherein mutually comparing, described proximal catheter end portion has relatively high hardness number, and described distal catheter portion has relatively low hardness number, described catheter body comprises suction chamber, described suction chamber extends through described catheter body from described proximal catheter end portion towards described distal catheter portion, described suction chamber comprises the suction socket of opening at described catheter body far-end, wherein said suction socket does not have structural barrier at the far-end of described catheter body, and the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends and has the opening similar with suction chamber size from the far-end of described catheter body, described distal portions has the opening wider than suction chamber, described catheter body comprises filling cavity further, and described filling cavity extends along described catheter body towards described distal portions, has the fill orifice extended through described catheter body, and described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
A kind of thrombectomy catheter is disclosed in another specific example, comprise catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, described catheter body comprises the suction chamber and filling cavity that extend along it, described catheter body has overall uniform cross-sectional profiles, and its hardness has the multiple hardness numbers varied along its length, under making mutually to compare, proximal catheter end portion has relatively high hardness number, and distal catheter portion has relatively low hardness number; Wherein said suction chamber extends through described catheter body from proximal catheter end portion towards distal catheter portion, described suction chamber comprises the suction socket of opening at described catheter body far-end, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends from the far-end of described catheter body, and wherein said distal portions has the cross section more strengthened than proximal part; And wherein said filling cavity extends along described catheter body towards described distal portions, have the fill orifice extended through described catheter body, described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
A kind of thrombectomy catheter is disclosed in another specific example, comprise catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, described catheter body comprises the suction chamber and filling cavity that extend along it, described catheter body has overall uniform cross-sectional profile, and its hardness has the multiple hardness numbers varied along its length, under making mutually to compare, proximal catheter end portion has relatively high hardness number, and distal catheter portion has relatively low hardness number; Wherein said suction chamber extends through described catheter body from described proximal catheter end portion towards described distal catheter portion, and described suction chamber comprises the suction socket of opening at described catheter body far-end; And wherein said filling cavity extends along described catheter body towards described distal portions, have the fill orifice extended through described catheter body, described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
In another specific example, disclose a kind of thrombectomy catheter, comprising: the catheter body comprising suction chamber, described suction chamber is through described catheter body extension and at suction socket place opening; Perfusion body, described perfusion body comprises the fluid conveyor chamber extending to fill orifice, and described perfusion body extends through described suction chamber; And expansion member, described expansion member is connected to the far-end of described perfusion body and is positioned at the distally of described fill orifice.
In another specific example, disclose a kind of thrombectomy system, comprising: fluid delivery system; Aspirator; And thrombectomy catheter, described thrombectomy catheter has the first port be connected with fluid delivery system and the second port be connected with aspirator, and wherein thrombectomy catheter comprises; Catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, and under wherein mutually comparing, proximal catheter end portion has relatively high hardness number, and distal catheter portion has relatively low hardness number; Suction chamber, described suction chamber extends through described catheter body from described proximal catheter end portion towards described distal catheter portion, described suction chamber comprises the suction socket of opening at described catheter body far-end, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends from the far-end of described catheter body, there is the opening similar with suction chamber size, and distal portions have the opening wider than suction chamber; Described catheter body comprises filling cavity further, and described filling cavity extends along described catheter body towards described distal portions, has the fill orifice extended through described catheter body, and described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
In another specific example, disclose the thrombectomy system above in several sections, wherein said aspirator comprises vacuum source, and described vacuum source comprises and forms a set of branched syringe by cock valve type manifold.
In another specific example, disclose the thrombectomy system above in arbitrary section, wherein said single fill orifice is recessed into towards nearside away from described suction socket.
The thrombectomy catheter above in arbitrary section is disclosed in another specific example, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends and has the opening similar with described suction chamber size from the far-end of described catheter body, and described distal portions has the opening wider than described suction chamber.
Remain and in another specific example, disclose a kind of ejector filler system comprise: shell, described shell maintains high-pressure pump, low-lift pump and suction module; Wherein thrombectomy catheter is configured to be connected to high-pressure pump or low-lift pump; Described high-pressure pump comprises further can with single piston pump of the pressure conveyance fluid between 5000psi to 10,000psi; And described low-lift pump comprise further can with the multiple-piston pump of the pressure conveyance fluid between 500psi to 1500psi.
Leading portion ejector filler system disclosed in another specific example, is wherein configured to running independent of one another by described high-pressure pump and described low-lift pump.
These examples can combine in the mode exchanging arbitrarily or combine.The general view of present patent application technical scheme that what content of the present invention provided is only.Do not intend to provide exclusive explanation of the present invention or explained in details.Further information about present patent application will be provided in detailed description book.
Accompanying drawing explanation
Accompanying drawing may not be made in proportion, and numeral identical in different views describes similar element.There are the different examples of the identical numeral like of different letter suffix.Usual done accompanying drawing is unrestricted as an example, also discusses various embodiment in presents.
Fig. 1 shows the thrombectomy catheter according to disclosure embodiment.
Fig. 2 shows the cross section of Fig. 1 thrombectomy catheter.
Fig. 3 shows the axonometric chart of Fig. 1 thrombectomy catheter distal portions.
Fig. 4 shows the side view of Fig. 1 thrombectomy catheter distal portions.
Fig. 5 shows the end view of suction socket element.
Fig. 6 A shows the side view of endovascular thrombectomy catheter 100, and combined by wide-mouth edge and thrombosis annular, thrombosis is stuck in wide-mouth distal end member.
Fig. 6 B shows the side view of the thrombectomy catheter of Fig. 6 A, and thrombosis collapse is in wide-mouth distal end member and move towards proximal catheter end.
Fig. 6 C shows the side view of the thrombectomy catheter of Fig. 6 B, thrombosis collapse more minor diameter conduit portion and move towards proximal catheter end.
Fig. 7 shows the cross section of the thrombectomy catheter according to disclosure embodiment.
Fig. 8 shows the far-end of the thrombectomy catheter according to disclosure embodiment.
Fig. 9 A shows the part thrombectomy system according to disclosure embodiment.
Fig. 9 B shows the ejector filler system according to disclosure embodiment.
Figure 10 shows the axonometric chart of the vacuum source according to disclosure embodiment.
Figure 11 shows the front view of Figure 10 vacuum source.
Figure 12 A shows the schematic diagram of the ejector filler system example according to disclosure embodiment.
Figure 12 B shows the schematic diagram of the ejector filler system example according to disclosure embodiment.
Figure 13 A shows the side view of the thrombectomy catheter according to disclosure embodiment.
Shown in Figure 13 B is the details sectional elevation of the expansion member used together with thrombectomy catheter shown in Figure 13 A.
Shown in Figure 14 is the detail view in suction socket with the thrombectomy catheter of Figure 13 A of tamper.
Shown in Figure 15 is the detailed side view of the thrombectomy catheter of Figure 14, and wherein tamper is mechanically driven into suction chamber.
Detailed description of the invention
Fig. 1 shows the side view of thrombectomy catheter 100 according to an embodiment of the invention.As what hereafter will describe in detail, in order to remove thrombosis from blood vessel, thrombectomy catheter 100 is configured to generate pressure fluid at far-end.In addition, in order to utilize pressure fluid to remove thrombosis, vacuum source (suction) is provided with at the far-end of thrombectomy catheter 100.Thrombectomy catheter 100 generally comprises the catheter body 102 extending to distal catheter portion 108 from proximal catheter end portion 104.The mid portion 106 of conduit extends between the proximal part 104 and distal portions 108 of conduit.In one embodiment, compared with proximal part 104, the distal portions 108 of catheter body 102 is more soft, and this set contributes to catheter body 102 and walks navigation in process in object vascular system.Catheter body 102 comprises suction chamber 110 and filling cavity 111, and described suction chamber 110 and filling cavity 111 extend to distal catheter portion 108 along catheter body 102 from proximal catheter end portion 104.
With reference to figure 1, as what hereafter will discuss, filling cavity 111 is connected to side ports 122, and described side ports 122 is connected to fluid delivery system.Fluid under pressure is transported to the distal portions 108 of conduit by filling cavity 111, such as, is transported to the jet orifice used in thrombectomy operation.In order to engage with thrombosis fluid dynamic, jet orifice produces the fluid jet of about 1500psi pressure, but also can get other force value.Suction chamber 110 is connected to central port, and described central port can be connected to vacuum equipment.
In use, thrombectomy catheter 100 is inserted in the blood vessel of such as vein or tremulous pulse, and transports fluid into distal catheter portion 108 by filling cavity 111.Fluid with the conveying of the form of one or multiple jets, and smashes endovascular thrombosis (such as, by the fluid pressure concentrated, fluid velocity and fluid flow) by fluid dynamic.Such as, fluid impact thrombosis, and mechanically macerate thrombosis by this kind of combination.As what hereafter will discuss, by the suction socket distal end member 114 of widening, suction chamber 110 absorbs the thrombosis be crashed to pieces, and is transported to waste unit by port one 20, such as collecting bag, liquid medicine bottle, chute etc.
catheter body
In one embodiment, catheter body 120 is shaped to distal portions 108 flexible relative, proximal part 104 and its more then relative rigid.The distal portions 108 of flexible relative makes catheter body 120 to advance along blood vessel neatly and can navigate within blood vessel neatly to realize the object being easy to insert.The proximal part 104 that catheter body 120 is harder take into account the torsion capacity such as more strengthened and the advance that can be more prone to along guide line.In one example in which, compared with other parts of catheter body, the far-end of catheter body 120 has the length of approximate 6 inches to have lower hardness.Because compared with 6533PEBAX, 7233PEBAX has lower hardness number, so in a kind of exemplary conduit, its distal portions 108 employs 6533PEBAX and proximal part 104 employs 7233PEBAX.
In another embodiment, with regard to the proximal part 104 of catheter body, mid portion 106 and distal portions 108, can find after independent to wherein each and other parts, proximal catheter end portion 104 has high hardness value, conduit mid portion 106 has relatively medium hardness number, and distal catheter portion 108 has relatively low hardness number.Example is above the same, and distal catheter portion 108 and the lower hardness number of mid portion 106 contribute to the conveying of conduit in vascular system and walk.Such as, catheter body 102 can through bending vascular system.The hardness number (being greater than mid portion) that proximal catheter end portion is relatively high assists to provide the promotion ability for catheter body 102 and torsion capacity.
Such as, if catheter body 102 is as described above, include three or multiple hardness number, this catheter body 102 can be formed by polyurethanes or PEBAX, its proximal catheter end portion 104 has the hardness DP of Durometer A hardness-A2, conduit mid portion 106 has the hardness DI of B1-B2, and distal catheter portion 108 has the hardness DD of C1-C2, wherein DP>DI>DD.Another kind of mode is expressed, and from proximal catheter end portion 104 to distal catheter portion 108, the hardness number (corresponding rigidity) of catheter body 102 reduces gradually.
Selectively, the catheter body 102 with multiple hardness number structure can by coextrusion process molding.In one example in which, full Intermittent pneumatic compression (TIE) technique is employed.In TIE technique, the polymer resin of two or more different hardness values is extruded from straight independent mould, the polymer of higher hardness value is used as the near-end of catheter body (such as, proximal catheter end portion 104), and be used as the far-end of catheter body (such as compared with the polymer of low durometer, distal catheter portion 108), there is middle transition region, the mid portion 106 of such as catheter body 102 between the two.As discussed before, in one example in which, as far-end, 7233PEBAX is used as near-end to 6233PEBAX.In one example in which, hardness number is uniform along the section extruding conduit of length variations along length.That is, tube material mixes with various amount gradually according to required hardness number, extrudes subsequently.In another example, the change of catheter body 102 hardness number comprises first extrudes in proximal part 104 and distal portions 108 one (such as in end to end mode, higher hardness value material or compared with the one in low durometer material), then for remaining distal portions 108 or proximal part 104, extrusion resin is changed into the material compared with low durometer or higher hardness value.
In other example, the section of conduit can have two-layer or two-layer above material.Such as, in one embodiment, the transitional region between far-end and near-end can mix such as hardness number changes to 7233PEBAX material from 6233PEBAX.Rephrase the statement, the material of multilamellar different hardness can coextrusion, also can to whole catheter body 102, by stopping or increasing layer to arrange the hardness number wanted.
Or in other example, catheter body 102 can use other known techniques of described description field to carry out molding, includes but not limited to, along the lining chamber draw, weld together etc. at the conduit tubing of joint by different-diameter.
Fig. 2 shows the sectional elevation of the thrombectomy catheter 100 described by disclosure embodiment.In this example, filling cavity 111 is positioned at off-centered position relative to suction chamber 110, and described filling cavity 111 has the next door 202 itself and suction chamber 110 separated.Catheter body 102 comprises outer catheter face and inner catheter face, and suction chamber 110 is limited by inner catheter face.As shown in the figure, outer catheter face is without feature, and filling cavity 111 is recessed relative to outer catheter face.In one example in which, recessed filling cavity 111 makes the section of cylinder be isodiametric, and this contributes to the transmission of catheter body 102 and walks.Further, recessed filling cavity 111 includes by the local configuration being positioned at suction chamber 110 of filling cavity sidewall institute molding.Filling cavity 111 is positioned at the edge of suction chamber 110, it is maximum for guaranteeing to can be used for the overall profile that aspirate thrombi material do not disturb by filling cavity through this suction chamber, and such as filling cavity is centrally located in suction chamber or againsts (being separated with the sidewall of suction chamber as the sidewall of filling cavity) along filling cavity wall.
In one embodiment, the diameter of catheter body 102 is 6French (Fr) and uses the seal wire of 0.014 inch to insert.In another embodiment, the diameter of catheter body 102 is 8French and uses the seal wire of 0.014 inch to 0.035 inch to insert.Selectively, the diameter of catheter body 102 can comprise other sizes, will use corresponding delivery guidewire accordingly.
In one example in which, catheter body 102 has uniform cross-sectional profiles.In other words, include filling cavity 111 with the cross-sectional cross section of the catheter body 102 of suction chamber be together with molding, correspondingly not there is closing line or the sealing wire of any type between the sidewall and the sidewall of suction chamber 110 of filling cavity 111.This and two chambeies respectively molding and then the structure that is bonded together in a subsequent step different.The even cross section of catheter body 102 provides firmer structure, this structure can prevent a chamber relative to the fracture in another chamber or stripping, because bending or moment of torsion or intracavity the pressure of any degree of conduit can not cause the fracture of closing line between two chambeies.Another kind of select, suction chamber 110 and filling cavity 111 can distinguish molding, use subsequently such as weld, bond, the method such as backflow links together.
Fig. 3 shows the axonometric chart of thrombectomy catheter 100 far-end 108 according to an embodiment.Fig. 4 shows the side view of thrombectomy catheter 100 far-end 108.As shown in each in these examples, distal portions includes suction socket 112 and fill orifice 304.As described herein, in the process of carrying out thrombectomy operation, suction socket 112 and fill orifice 304 cooperatively interact and hydrodynamically remove thrombosis from blood vessel, macerate thrombosis and detach thrombosis from blood vessel.
filling system
Referring again to Fig. 3 and 4, filling cavity 111 along catheter body 102 distally part 108 extend, described filling cavity 111 has the fill orifice 304 (such as through the sidewall of catheter body next-door neighbour filling cavity 111) running through catheter body, and described fill orifice 304 guides the fluid jet penetrated from catheter body 102.As described herein, the fluid source fluid that filling cavity 111 is used to provide pressure fluid with configuration is connected, and described pressure fluid can be at such as about 1500psi or the saline under being less than 1500psi pressure.Transmission pressure fluid passes fill orifice 304, and by fill orifice 304 adjust flux to form thrombectomy surgical fluid jet.
In an embodiment of the present disclosure, single fill orifice 304 is arranged to the structure of the longitudinal axis radial direction injection that fluid jet can be guided from catheter body 102.Such as, single fill orifice 304 points to direction away from catheter body 102 to guarantee that the fluid jet generated at fill orifice impacts towards the endovascular thrombosis around catheter body 102.By rotary guide pipe body 102 (such as proximal part 104 has the catheter body of more high hardness value), fill orifice 304 and corresponding fluid jet have passed through the whole yardstick of blood vessel, therefore, it is possible to remove the whole thrombosis around distal catheter portion 108.In one example in which, the diameter of fill orifice 304 is approximately 0.009 inch.In another example, the diameter of fill orifice 304 is approximately 0.012 inch.Selectively, can according to source of pressurised fluid (such as, the pressure of the pumping system be connected with catheter body 102 and flow velocity), the diameter of configuration fill orifice 304 has to produce the fluid jet needing speed and rate of flow of fluid.In other words, the shape and size configuring fill orifice 304 coordinate to arrange fluid jet tool velocity amplitude in need and flow speed value with fluid source.
In example as described above, be provided with single fill orifice 304.In other example, one or more position of catheter body 102 is provided with multiple fill orifice 304 (such as, radial loop is around distal catheter portion 104, longitudinal direction etc.).As shown in Figure 4, single fill orifice 304 has concentrated the fluid dynamic of perfusion of fluid can to smash thrombosis better.That is, by using single fill orifice 304, even if use lowpressure stream body source (such as, there is the 1500psi of 1 to 3cc low flow velocity or be less than 1500psi) also can have the fluid jet of enough hydrodynamic energy to implement thrombectomby operation in hole 304 generation, and under normal conditions, be the fluid source (such as, 10 being to provide high-pressure fluid that described fluid jet prepares, 000psi or 10, more than 000psi).The concentrated jet at fill orifice 304 place then can be walked around human vas, there is provided and use multiple conduit to carry out high pressure thrombectomy to treat similar effect, multiple conduits of above-mentioned use have multiple jet orifice and have the firm structure being enough to transferring high voltage fluid.
The different embodiment of thrombectomy catheter 100 uses different perfusion of fluid flow velocitys.Conduit in an example uses the flow velocity of about 1.5cc/sec to provide fluid jet at fill orifice 304, and described fluid jet is set to remove and macerate thrombosis.2cc/sec is used in another example.Or in another example, use about 3cc/sec.As also described above, speed when perfusion of fluid leaves fill orifice 304 and flow velocity depend on the flow velocity of fluid source and the size and dimension of pressure and fill orifice 304.As what will describe below this paper, the lowpressure stream body source of such as medicine ejector filler or radiography ejector filler can be used as the fluid source of thrombectomy catheter 100.The thrombectomy catheter 100 with fill orifice 304 and filling cavity 111 described herein is because herein is provided a kind of thrombectomy system, this system is using low pressure and low flow velocity (such as, medicine and radiography) ejector filler time also can set for effective place to go and macerate thrombosis, and the high-pressure fluid source necessarily do not used in other thrombectomy operation.
In one example in which, filling cavity 111 and fill orifice 304 are configured to, and mitigation haemolysis and hydrodynamic energy are to the destruction of hemocyte.For mitigation haemolysis, rate of flooding is limited in the scope of about 20m/sec to about 30m/sec by native system.In one example in which, the size and dimension setting fill orifice 304 to coordinate (correspondingly coordinating with source of pressurised fluid) with the flow velocity through conduit, to guarantee that the rate of flooding at hole 304 place is between about 20m/sec to about 30m/sec.By concentrating the perfusion stream through fill orifice 304, described fill orifice 304 has the diameter of regulation and shape and have single position in catheter body 102, while the jet being provided for the localization perfusion of fluid that thrombosis is macerated, rate of flooding is that appearance is manageable.
suction system
In this example, suction chamber 110 is included in the suction socket 112 of catheter body 102 far-end 113 opening.In one example in which, the impenetrable collar of ray is positioned at distal portions 108.Under fluoroscopy, in the process of interspersed blood vessel, the impenetrable collar of ray assists distal catheter portion 108 imaging.
In one example in which, far-end 113 comprises the suction socket distal end member 114 (such as, compared with the part of contiguous catheter body 102, having the wide-mouth part that profile more strengthens) of widening.As shown in Figure 3, the suction socket distal end member 114 of widening comprises the proximal part 116 being connected to catheter body 112 end 117.The suction socket distal end member 114 of widening comprises the opening similar to suction chamber 110 size at proximal part 116.The far-end 118 of the suction socket distal end member 114 of widening comprises the opening more widened than suction chamber 110.By one or more in the techniques such as heat seal, welding, bonding, backflow, the suction socket distal end member 114 of widening is connected to the end of catheter body 102.As what hereafter will discuss further, this that widen, funnel shaped distal end member 114 (such as, wide-mouth feature) will improve suction.
Fig. 5 shows not with under catheter body 102 connection status, the end view of the suction socket distal end member 114 of widening.Fig. 6 A shows the side view of the thrombectomy catheter 100 being positioned at blood vessel 604, this thrombectomy catheter 100 have with its connection and be combined with thrombosis 602 widen suction socket distal end member 114.
Referring again to Fig. 5, the wide-mouth widening suction socket distal end member 114 defines introversion inclined-plane 502, described introversion inclined-plane 502 distally 118 extends inward into the near-end widening suction socket distal end member 114, and described near-end is connected to catheter body 104 and is communicated with suction chamber 110.In one example in which, the interface relative smooth between the suction socket distal end member 114 of widening and suction chamber 110 or flush, this contributes to thrombosis from the suction socket distal end member 114 of widening to the transition of suction chamber 110.
As shown in figs. 5 and 6, widen suction socket distal end member 114 and there is no structural barrier from its top to the internal volume itself and catheter body 102 junction.In other words, introversion inclined-plane 502 is continuous print substantially, so there is no any obstruction (such as, protuberance, projection etc.).That is, distal end member 114 far-end 118 this far-end and closely this far-end be continuous print (such as, not having barrier) substantially.Therefore, enter into conduit when thrombosis 602 is sucked, thrombosis is at the far-end of distal end member 114 or become wedge shape in distal end member 114.Then the infundibulate of distal end member 114 touch thrombosis and seals, and the swabbing pressure of suction chamber 110 continues application of vacuum, and make thrombosis 602 collapse enter into narrow suction socket distal end member 114 of widening gradually to be suitable for suction chamber 110 and the less block that can transmit along suction chamber 110 to make thrombosis be broken into size.
Fig. 6 B and 6C shows the further details of the thrombosis be sucked.Fig. 6 B is the side view of thrombectomy catheter 110, wherein thrombosis 602 collapse and shifting towards nearly catheter end in wide-mouth distal end member 114.Fig. 6 C shows the side view of thrombectomy catheter 110, wherein thrombosis 602 by collapse (or crush) in thrombectomy catheter 110 more small diameter portion and towards catheter proximal end transfer in order to discharge.
Described wide-mouth shape decreases the generation of any divided fluid stream of the air gap periphery between thrombosis and suction chamber, this divided fluid stream (such as, leak) decrease the swabbing pressure (such as, vacuum) acting on and widen thrombosis in suction socket distal end member 114.That is, the suction socket distal end member 114 of widening of unobstructed annular makes thrombosis along element in place, and substantially to prevent from forming gap between thrombosis and distal end member 114 inner process thing.Fluid around thrombosis leaks and therefore substantially minimizes, and the suction chamber 110 of vacuum is applied on thrombosis.
Fig. 7 shows the sectional elevation of thrombectomy catheter 702, and wherein filling cavity 711 is positioned the sidewall of conduit completely.This outfit of filling cavity ensure that the section of suction chamber 710 is isodiametric substantially.In some instances, isodiametric suction chamber 710 (not having barrier) contribute to absorbing and thrombosis through the transport of inner chamber.Another kind of selection, conduit 702 is in a part of conduit, such as, in the conduit of far-end 108 or near-end 104, filling cavity 711 is in the sidewall of conduit, and in another part conduit portion, such as, in the conduit of near-end 104 or far-end 108, filling cavity 711 part of another part appears in suction chamber (as shown in Figure 2).Therefore needing efficient conveying thrombosis proximally through the place of suction chamber, conduit 702 includes isodiametric suction chamber 710.
Fig. 8 shows the far-end according to the thrombectomy catheter 802 described in another embodiment.In this example, the end of wide-mouth distal end member 814 has the shape 815 on band inclined-plane.Widen the shape assistance device of suction socket distal end member 814 with inclined-plane and be inserted into blood vessel and assistance device is walked at Ink vessel transfusing.Inclined plane shape 815 is the convergents that are inclined upwardly from the top of a far-end towards proximal part 824.The suction socket 820 of widening suction socket distal end member 814 absorbs thrombosis.Effect and the wide-mouth distal end member 114 as described above of inclined plane shape are similar.Therefore, widen suction socket distal end member 814 without any structural barrier, touch the thrombosis in distal end member 814 circlewise, and touch all thrombosis sealings in case the air gap periphery generation fluid between tampon and suction chamber leaks.
pressurized fluid transfer system
Fig. 9 A shows a part for the thrombectomy system 900 according to an embodiment.This thrombectomy system 900 comprises thrombectomy catheter 100 as shown in Figure 1, this thrombectomy catheter 100 has side ports 122 and central port, described side ports 122 is connected to the fluid conveying device of such as ejector filler 902, and described central port is connected to the aspirator 904 of such as vacuum source.
For example, in use, thrombectomy catheter 100 uses seal wire to be inserted into blood vessel.Guide the distal portions 108 of thrombectomy catheter 100 through vascular system and place it in the position being close to thrombosis.For example, ejector filler 902 is set to carry perfusion of fluid with about 1cc/s, 1.5cc/s, 2cc/s or 3cc/s etc.Ejector filler 902 includes but not limited to, is configured for one or more the low pressure ejector filler in radiography transmission or medicine transmission.Configure lowpressure stream body source in scope between about 300psi to about 2000psi and provide perfusion of fluid to thrombectomy catheter 100 (802).As discussed hereinbefore, according to these the lower fluid pressures provided by ejector filler 902 (and the high pressure used in performing the operation with other thrombectomyes compare with high streaming flow source comparatively low flow velocity), can need flow behavior (such as by being configured to provide to have to the shape of filling cavity 111 and fill orifice 304 and diameter, speed and flow velocity) fluid jet, the configuration of described fluid jet is with removing and macerating thrombosis.As discussed in this article, provide single fill orifice 304 fluid jet can be confined to single position, and consider that the fluid that use comparatively compresses power still can remove thrombosis.Rephrase the statement, single fill orifice 304 can avoid consequence during multiple pressure port pressure drop, the substitute is single fill orifice 304 and can concentrate the fluid dynamic energy provided by low pressure ejector filler 902 in single position.Other fluid conveying device can be used, such as hand-held ejector filler, high pressure jetting device (such as, 10,000psi) etc. in other example.The thrombectomy catheter 100 with fill orifice 304 and filling cavity 111 described herein provides one, when use contains low pressure and low flow velocity (such as medicine and the radiography) ejector filler of continuous transmission pump, still effectively can be configured to the thrombectomy system of removing and macerating thrombosis, and do not need expensive and special high-pressure fluid source (such as, pump, ejector filler etc.).
When perfusion of fluid removal with when smashing thrombosis, the aspirator 904 that startup is connected with suction chamber 110 is to aspirate material.Aspirator 904 comprises the vacuum source of such as vacuum syringe, vacuum pump etc.
Another embodiment shown in Fig. 9 B is the ejector filler system 1200 can share with native system, such as Medrad
ejector filler system.This example employs control module 1400 and power ejector filler 1300, syringe is connected to described power ejector filler 1300.Fluid control module 1400 combines the fluid flowing that ejector filler 1300 is used for controlling to be transmitted by ejector filler 1300 together.Fluid control module 1400 is applicable to convection cell path device group usually to carry out supporting and controlling, and described fluid path set is used for the syringe be associated with ejector filler 1300 to be connected to the conduit (not shown) that will be associated with patient.Saline source 1706 is connected with peristaltic pump 1408 fluid.
As what discuss further herein, fluid delivery system 1200 comprises the supporting component 1600 be applicable to for supporting ejector filler 1300 and fluid control module 1400 further.Supporting component 1600 can be configured to moveable platform or base, make fluid delivery system 1200 normally transportable, or just be connected to standard hospital sick bed or the examining table at patient place in injection manipulation.In addition, fluid delivery system 1200 preferably comprises user's input control part or device 1800 further, computer hardware/the software (such as, electronic memory) of described user's input control part or device 1800 and fluid control module 1400 and/or ejector filler 1300 is mutual.Fluid control module 1400 generally includes shell 1402, the valve actuator 1404 controlling control valve for fluids, level detection mechanism 1406, peristaltic pump 1408, automatic shutoff valve or automatic clamp pipe valve, and air detection assembly.
As indicated, fluid control module 1400 is applicable to convection cell path external member 1700 usually to carry out supporting and controlling, and described fluid path external member 1700 is used for the syringe be associated with ejector filler 1300 to be connected to conduit (not shown).Relate in the injection operation of fluid delivery system 1200 common, ejector filler 1300 is filled with the fluid from first fluid container 1704, and by fluid path external member 1700, this fluid is transported to conduit, and is finally transported to patient.Fluid control module 1400 is general by controlling with the associated valve of fluid path external member 1700 or managing the conveying of injection, and described valve is controlled by the valve actuator 1404 in control module 1400 or activated.
Fluid control module 1400 is applicable to being transmitted the fluid from second fluid container 1706 under stress by the peristaltic pump 1408 on fluid control module 1400 further.In one embodiment, hand held controller 1000 contains plunger and to control or bar controls 1010, and when under the first pressure/low-pressure pattern, operator presses the flowing that described plunger or bar control the fluid from syringe 1300.Plunger 1010 is pressed far away, flow velocity larger (such as, by the potentiometer of such as linear potentiometer and so on being positioned at controller 1000 shell).In one embodiment, operator can use graphical user interface displays device that the pattern of plunger 1010 is changed to the second pattern, and in a second mode, just as operator programmes in advance, ejector filler 1300 causes high-pressure injection.
Figure 10 shows the axonometric chart of the vacuum source 950 according to an embodiment.Figure 11 shows the front view of vacuum source 950.
In this example, vacuum source 950 is the vacuum sources that can reset.In one example in which, native system as described above uses the syringe of 150cc capacity by the automatic radiography ejector filler of perfusion of saline.In this example, the pumping volume of sucking type device (such as, vacuum source 950) uses similar size.Such as, if use the 30cc syringe of standard together with ejector filler 902, so when the 30cc syringe of corresponding vacuum source 950 is full of, in order to avoid fluid net anatomically reduces or net increase, operation will stop.
In the example shown in Figure 10 and 11, vacuum source 950 comprises a series of 60cc syringe 952, and described syringe forms a set of by cock valve type manifold 954.The personnel in affiliated field are appreciated that the quantity that syringe uses and size can change.Selectively, as compared to irrigation source (such as, ejector filler 902), multiple syringe 952 can have the capacity more strengthened, and before all operations, multiple syringe 952 can all be reseted.In one example in which, shaped as frame retainer 956 is connected to vacuum source assembly 950, to make syringe 952 upright and visual (correspondingly liberating both hands).Any amount of syringe 952 can be used according to the size of manifold 954 and required suction intensity (and capacity of ejector filler).
In use, vacuum source 950 (such as, aspirator 904) is connected to thrombectomy catheter 100 by luer connector, and opens one or more plug valve.After aspirator 904 is opened, be sucked material, such as, pour into conduit 100 through the suction socket distal end member 114 of widening, be transferred with tailing edge suction chamber 110, enter into the syringe 952 that one or more has been opened.After one or more syringe is full of, if need other syringe, then open other syringe.If operated, closed injection device 952, has for example used cock valve type manifold 954, and has changed or clean injectors 952, for subsequent operation is prepared.
injection system
Figure 12 A shows the schematic diagram of the ejector filler system example 1800 according to a disclosure embodiment.Figure 12 B shows the schematic diagram of another example 1900 of ejector filler system according to a disclosure embodiment.
Described ejector filler system 1800,1900 is the fluid management mechanism that can use together with interposing catheter with various diagnostic catheter.This system combines the transmission of various fluid and operating capability.
With reference to figure 12A, ejector filler system 1800 comprises the single piston pump 1802 of high pressure.Such as, configuring this pump for standard thrombectomy catheter provides high-pressure fluid to transmit.The pressure of about 5,000psi to about 10,000psi is provided in some instances.
System 1800 comprises multiple-piston pump 1804 further.Configuration multiple-piston pump 1804 provides middle pressure/low pressure flowing for imaging contrast transmission, irrigation and the fluid that above-mentioned thrombectomy catheter 100 will be used to carry out applying.Configuration multiple-piston pump 1804 is with about 1500psi and come infusion contrast agent or saline to the flow velocity of 50ml/sec greatly.Some option has the transmission pressure of about 1000psi.The scope of some can from 500psi to 2500psi.Pump 1804 is continuous-flow pump (such as, it need not carry out Reperfu-sion as syringe pump).
A kind of selection comprises single piston pump 1806 further.Configuration pump 1806 is with 1500psi and come infusion contrast agent or saline to the flow velocity of 50ml/sec greatly, but this pump must Reperfu-sion.In some embodiments of system 1800, pump 1806 or pump 1804 are omitted.
In order to transport fluid into conduit or other instruments, each in pump 1802,1804 and 1806 is operably connected to the fluid line 1810 of outlet.Being designed to by pump 1802,1804 and 1806 can independent operation, and wherein once only a pump can conveyance fluid.
System 1800 comprises suction module 1812 further.Suction module 1812 be configured to by or delivery conduit or independent conduit draw back fluid.
Each in pump 1802,1804 and 1806 is configured to a shared common structure.Such as, system 1800 optionally can comprise operating power system 1820, graphic user interface (GUI) 1822, fluid guarantee/air detection module 1824, and one or more volume flow body source 1826,1828.Include configuration in selecting at one to be used to provide hydrodynamic mixing and to monitor the module 1832 of fluid 1826,1828 residual capacity.In some are selected, multifunctional disposable, mutual and information communication and conduit/one-off recognition are prepared further.
In various embodiments, some feature combines in a different manner as discussed above.In the configuration of an example, by pump 1802 and 1804 and suction module 1812, and in standard thrombectomy catheter, thrombectomy catheter 100 or diagnostic catheter at least one or multiplely to combine.In the configuration of another example, by pump 1802 and 1806 and suction module 1812, and in standard thrombectomy catheter, thrombectomy catheter 100 or diagnostic catheter at least one or multiplely to combine.Still in the configuration of another example, by pump 1804 and suction module 1812, and one or more in thrombectomy catheter 100 or diagnostic catheter combines.In other configuration, by pump 1806 and suction module 1812, and one or more in thrombectomy catheter 100 or diagnostic catheter combines.But in the configuration of another one example, one or more in pump 1806 and suction module 1812, thrombectomy catheter 100 or diagnostic catheter is combined.Another configuration is combined with one or more with conduit 100 or diagnostic catheter of pump 1806.Another configuration includes single pump piston 1806, and can work together with radiography ejector filler or thrombectomy catheter 100 as discussed above.Conversely speaking, first to describe configuration more complicated, because its compatible all conduit and all-round.
By being provided in a compact system by all different functions, fluid injection system 1800 can be used for multiple situation.General injection system or high pressure or low pressure, so this two cover system medical worker must will have, and all want to use.By combining system.By combined system, ejector filler system 1800 more easily uses, because device minimizes and learning curve minimizing.Other beneficial effect comprises saves time, reduces consumption, does not take other ground space and the device availability for any operation.
With reference to figure 12B, ejector filler system 1900 can comprise all features of ejector filler system 1800 as discussed above, and those features do not come into question.Similarly, the identical multipurpose configuration utilizing various conduit can also be used.
Here, ejector filler system 1900 includes multiple-piston pump 1902, this multiple-piston pump 1902 can carry use in contrast imaging, use in flushing liquor, or the low-pressure fluid 1904 that uses together with above-mentioned thrombectomy catheter 100.Further, multiple-piston pump 1904 can be carried and use high-pressure fluid 1908 together with standard thrombectomy catheter.
Again, by being provided in a compact system by all different functions, fluid injection system 1900 can be used for multiple situation.General injection system or high pressure or low pressure, so this two cover system medical worker must will have, and all want to use.By combined system, ejector filler system 1900 more easily uses, because device minimizes and learning curve minimizing.Other beneficial effect comprises saves time, reduces consumption, does not take other ground space and the device availability for any operation.
thrombectomy catheter
Figure 13 A shows the side view of the embodiment of the thrombectomy catheter 2000 according to one or more embodiment of the disclosure.Thrombectomy catheter 2000 generally comprises catheter body 2002, and described catheter body 2002 comprises suction chamber 2052 (see Figure 14 and 15), and described suction chamber 2052 extends through catheter body 2002, and at the suction socket 2005 place opening of far-end.Such as use haemostatic valve, accessory etc., suction chamber 2052 is communicated with suction ports 2004, and described suction ports 2004 can be connected to vacuum source as discussed above.Vacuum source includes but not limited to syringe, Dewar bottle, roller pump, vacuum pump etc.Thrombectomy catheter 2000 comprises fluid injection port 2007 (comprising haemostatic valve, accessory etc. similarly).In this example embodiment, fluid can transmit through perfusion body 2008, and described perfusion body 2008 can be rustless steel hypotube, polymer tube, Nitinol tube etc.Perfusion body 2008 can comprise the Connection Element 2030 being connected to ejector filler source, and described ejector filler source can be ejector filler as discussed above.Perfusion body comprises inner chamber, and described inner chamber extends through perfusion body and have fill orifice 2010 near distal catheter portion 2016.Use single fill orifice 2010 in one example in which.Perfusion body extends through catheter body 2002 in suction chamber 2052.
Figure 13 A further illustrates the seal wire 2066 and expansion member (2020, be hereafter described) that extend through catheter body 2002.Seal wire 2066 contributes to navigating through vascular system, and further contemplated when maintaining perfusion body 2008 (and expansion member) concordance relative to catheter body 2002, the described parts slip relative to each other of thrombectomy catheter is moved.As shown in FIG. 13A, seal wire 2066 extends through manifold 2012, and described manifold 2012 is connected with proximal catheter end portion 2018.Seal wire 2066 enters manifold 2012 through entry port 2014.With other ports, comprise suction ports 2004 the same with fluid injection port 2007, in order to the sealing contributed to through the seal wire 2066 of manifold 2012 is transmitted, haemostatic valve is selectively arranged on entry port 2014.The sealed environment be arranged in thrombectomy catheter 2000 take into account the perfusion of fluid comprising entrained particles from perfusion body 2008 and distal end of catheter port 2016 (such as, being close to the expansion member 2020 at suction socket 2005 place) suction.
Expansion member 2020 is connected to the far-end of perfusion body 2008, and is positioned at that one end away from fill orifice.Shown in Figure 13 B is the details sectional elevation of expansion member 2020.The diameter of expansion member 2020 is greater than perfusion body 2008.The size of expansion member 2020 can put into suction socket 2005 in one example in which.In one example in which, expansion member 2020 comprises distal portions 2035 and one or more Marking ring 2022 of taper.In some instances, expansion member 2020 comprises glueballs or other coil.In other example, suction chamber 2052 includes the suction socket distal end member 114 of widening such as shown in Fig. 3 and 4.Selectively, expansion member 2020 is that taper is to contribute to being delivered into suction socket 2005 near the part of near-end.
As shown in Figure 13 B further, expansion member 2020 includes the perfusion body recess 2060 that size and dimension can hold perfusion body distal end 2062 (such as, the far-end of hypotube provides perfusion of fluid to arrive fluid perfusion hole 2010).In one example in which, perfusion body distal end 2062 uses at least one mechanism to be fixedly connected with expansion member, and described mechanism includes but not limited to pour into the binding agent, crimping, bag injection molding (overmolding), mechanical interference etc. in body recess 2060.In another example, the size and dimension of expansion member 2020 can accept the slip of apparatus, the seal wire in described apparatus such as silk guide passage 2064.In Figure 13 B, seal wire 2066 shows and extends through expansion member 2020.Selectively, silk guide passage 2064 comprises at least part of non-directional passage as shown in the figure, and described non-directional passage comprises such as elbow 2068.In another is selected, silk guide passage 2064 is positioned at the position at expansion member 2020 center substantially.Using seal wire 2066 as track, expansion member 2020 is taken seal wire 2066 and is advanced.Or in another example, silk guide passage be arranged on perfusion body 2008 in, therefore with identical structure in conjunction with seal wire and perfusion body 2008.
Expansion member 2020 can configure for removing the material tamper 2050 be stuck in suction socket 2005.Such as, as shown in figure 14, thrombosis tamper 2050 fills in the top 2040 at thrombectomy catheter 2000.As shown in figure 15, retract perfusion body 2008 (being exactly that catheter tip 2040 moves advance through expansion member 2020 on the contrary) and can blocking be removed, therefore do not need mobile conduit in body just can recover suction.Selectively, expansion member 2020 and perfusion body 2008 can be mobile in catheter body 2002, such as, slided relative to the proximal slide of catheter body or far-end by perfusion body 2008.Or in another example, expansion member 2020 and perfusion body 2008 can be arranged to single device, the size and dimension of described device can use together with one or more standard transmission conduit or standard interposing catheter, and these conduits have the inner chamber that size can receive perfusion body 2008 and expansion member 2020.
In operation, thrombosis fills in suction socket 2005.User is by towards either direction (clockwise or counterclockwise) once or multiple rotary perfusion body 2008 and handle perfusion body 2008 by longitudinally moving back and forth perfusion body relative to catheter body 2002.Just as shown in FIG. 14 and 15, expansion member 2020 moves relative to seal wire 2066 as sliding members, and described seal wire 2066 is accommodated in silk guide passage 2064.Correspondingly seal wire 2066 is used as the track of expansion member 2020.Seal wire 2066, also can be accommodated in suction chamber 2052, is used for assisting expansion member 2020 center to aim at suction chamber 2052.
When expansion member 2020 is in suction chamber 2052, in fact expansion member 2020 promotes (such as, fill in, mechanical bond etc.) thrombosis 2050 enters into suction chamber 2052 and along suction chamber 2052 under.Meanwhile, fill orifice 2010 is positioned at the suction chamber 2052 of catheter body 2002, and pour into jet 2054 assist smash thrombosis 2050.Expansion member 2020 is used as the connector of suction socket 2005, and pours into jet and will point to the thrombosis of blocking, and the perfusion jet 2054 flowed out from perfusing hole 2010 will with thrombosis through suction chamber 2052.In other words, fill orifice 2010 and the perfusion jet 2054 generated and the mechanical bond (such as, inserting) provided by expansion member match the incompatible material tamper 2050 removed in suction socket 2005 place and suction chamber 2052.This combination function can minimize and substantially eliminate the blocking of suction chamber 2052, even if what carry through fill orifice 2010 is low-pressure injection fluid.
In this example, expansion member 2020 and catheter body 2002 coordinate can remove in thrombosis 2050 abandon using as described above widen suction socket distal end member 114.This makes device can not cause thromboembolism or angiolysis through blocking and vascular system smoothly.In some instances, widen suction socket distal end member 114 also to use together with expansion member 2020.
note
Detailed description above with reference to accompanying drawing, these accompanying drawings also seat describe in detail a part.By way of example, accompanying drawing shows specific embodiment, can implement the present invention in these embodiments.These embodiments are herein also referred to as " example ".These examples can comprise other elements except illustrating or describing.But the present inventor also accepts the example only providing element shown by those or described element.In addition, the present inventor also accepts illustrating or describing the example (or one or more aspect of these examples) that element carries out combination in any or exchange, or about specific example (or these examples one or more in), or about shown or described herein other examples (or other examples one or more in).
All publications, patent and patent document herein are all included in herein as a reference, just as they are included in separately as a reference.Should include in as a reference like this when using inconsistent between presents and above-mentioned file, include reference in use should regard supplementing presents as; Inconsistent for what can not be in harmonious proportion, use presents.
In this document, the term " a " used or " an ", the same with general patent document, comprise more than one or one, independent of any example or the use of " atleastone " or " oneormore ".In presents, belong to " or " and be used to refer to non-exclusive situation, such as " AorB " comprises " AbutnotB ", " BbutnotA " and " AandB ", except as otherwise noted.In accompanying claims, term " including " and " inwhich ", as the English be easily understood, equal term " comprising " and " wherein " respectively.Same; in the following claims; term " including " and " comprising " are open, that is, include except element listed after these terms also to drop into the system of external component, device, article or technique within the protection domain of claim.In addition, in claim below, term " first ", " second " and " third " etc. are only used as label, do not intend to force numerical requirements to their target.
Claims (24)
1. a thrombectomy catheter, comprising:
Catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, described catheter body comprises the suction chamber and filling cavity that extend along it, described catheter body has overall uniform cross-sectional profiles, and there are the multiple hardness numbers varied along its length, make mutually relatively under, described proximal catheter end portion has relatively high hardness number, and described distal catheter portion has relatively low hardness number;
Wherein said suction chamber comprises the suction socket of opening at described catheter body far-end; And
Wherein said filling cavity extends along described catheter body towards described distal portions, and comprises the single fill orifice configuring and be used for guiding fluid jet to penetrate from the longitudinal axis radial direction of described catheter body.
2. thrombectomy catheter as claimed in claim 1, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends and has the opening similar with described suction chamber size from the far-end of described catheter body, and described distal portions has the opening wider than described suction chamber.
3. thrombectomy catheter as claimed in claim 1, wherein said suction chamber does not have structural barrier along the length of catheter body.
4. thrombectomy catheter as claimed in claim 1, wherein said suction socket comprises circular cross sectional shape.
5. thrombectomy catheter as claimed in claim 1, wherein said single fill orifice is recessed into towards nearside away from described suction socket.
6. a thrombectomy catheter, comprising:
The catheter body of distal catheter portion is extended to from proximal catheter end portion;
From described proximal catheter end portion towards described distal catheter portion through the suction chamber that described catheter body extends, described suction chamber comprises suction socket near described distal catheter portion, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends and has the opening similar with described suction chamber size from the far-end of described catheter body, and described distal portions has the opening wider than described suction chamber; And
Along the filling cavity that described catheter body distally partly extends, described filling cavity has the single fill orifice being positioned at described catheter body sidewall, and described single fill orifice configuration is used for guiding fluid jet to penetrate from the longitudinal axis radial direction of described catheter body.
7. a thrombectomy catheter, comprising:
Catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, under wherein mutually comparing, described proximal catheter end portion has relatively high hardness number, and described distal catheter portion has relatively low hardness number;
Described catheter body comprises suction chamber, described suction chamber extends through described catheter body from described proximal catheter end portion towards described distal catheter portion, described suction chamber comprises the suction socket of opening at described catheter body far-end, wherein said suction socket does not have structural barrier at the far-end of described catheter body, and the far-end of described catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends and has the opening similar with suction chamber size from the far-end of described catheter body, described distal portions has the opening wider than suction chamber,
Described catheter body comprises filling cavity further, and described filling cavity extends along described catheter body towards described distal portions, has the fill orifice extended through described catheter body, and described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
8. thrombectomy catheter as claimed in claim 7, wherein said fill orifice comprises configuration and is used for guiding to the single fill orifice of fluid jet from the longitudinal axis radial direction injection of described catheter body.
9. a thrombectomy catheter, comprising:
Catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, described catheter body comprises the suction chamber and filling cavity that extend along it, described catheter body has overall uniform cross-sectional profiles, and its hardness has the multiple hardness numbers varied along its length, under making mutually to compare, proximal catheter end portion has relatively high hardness number, and distal catheter portion has relatively low hardness number;
Wherein said suction chamber extends through described catheter body from proximal catheter end portion towards distal catheter portion, described suction chamber comprises the suction socket of opening at described catheter body far-end, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends from the far-end of described catheter body, and wherein said distal portions has the cross section more strengthened than proximal part; And
Wherein said filling cavity extends along described catheter body towards described distal portions, has the fill orifice extended through described catheter body, and described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
10. a thrombectomy catheter, comprising:
Catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, described catheter body comprises the suction chamber and filling cavity that extend along it, described catheter body has overall uniform cross-sectional profile, and its hardness has the multiple hardness numbers varied along its length, under making mutually to compare, proximal catheter end portion has relatively high hardness number, and distal catheter portion has relatively low hardness number;
Wherein said suction chamber extends through described catheter body from described proximal catheter end portion towards described distal catheter portion, and described suction chamber comprises the suction socket of opening at described catheter body far-end; And
Wherein said filling cavity extends along described catheter body towards described distal portions, has the fill orifice extended through described catheter body, and described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
11. 1 kinds of thrombectomy systems, comprising:
Fluid delivery system;
Aspirator; And
Thrombectomy catheter, described thrombectomy catheter has the first port be connected with fluid delivery system and the second port be connected with aspirator, and wherein thrombectomy catheter comprises;
Catheter body, described catheter body extends to distal catheter portion from proximal catheter end portion and comprises conduit mid portion, and under wherein mutually comparing, proximal catheter end portion has relatively high hardness number, and distal catheter portion has relatively low hardness number;
Suction chamber, described suction chamber extends through described catheter body from described proximal catheter end portion towards described distal catheter portion, described suction chamber comprises the suction socket of opening at described catheter body far-end, the far-end of wherein said catheter body comprises suction socket distal end member, described suction socket distal end member comprises proximal part and distal portions, described proximal part extends from the far-end of described catheter body, there is the opening similar with suction chamber size, and distal portions have the opening wider than suction chamber;
Described catheter body comprises filling cavity further, and described filling cavity extends along described catheter body towards described distal portions, has the fill orifice extended through described catheter body, and described fill orifice is used for guiding fluid jet to penetrate from described catheter body.
12. thrombectomy systems as claimed in claim 11, wherein said aspirator comprises vacuum source, and described vacuum source comprises and forms a set of branched syringe by cock valve type manifold.
13. 1 kinds of thrombectomy catheters, comprising:
Comprise the catheter body of suction chamber, described suction chamber is through described catheter body extension and at suction socket place opening;
Perfusion body, described perfusion body comprises the fluid conveyor chamber extending to fill orifice, and described perfusion body extends through described suction chamber; And
Expansion member, described expansion member is connected to the far-end of described perfusion body and is positioned at the distally of described fill orifice.
14. thrombectomy catheters as claimed in claim 13, the size of wherein said expansion member is greater than the size of described perfusion body cross-section.
15. thrombectomy catheters as claimed in claim 13, the size of wherein said expansion member at least can partly load described suction socket.
16. thrombectomy catheters as claimed in claim 13, wherein said perfusion body comprises single fill orifice.
17. thrombectomy catheters as claimed in claim 13, wherein said thrombectomy catheter is configured to, and described expansion member can be pulled in described suction chamber, to contact all thrombosis be stuck in suction socket.
18. 1 kinds of methods comprise:
Use thrombectomy catheter to perform thrombectomby operation, the perfusion body that described thrombectomy catheter has suction chamber and extends through described suction chamber, described perfusion body comprises fill orifice and is positioned at the expansion member in described fill orifice distally;
Handle described perfusion body and enter into described suction chamber to move described expansion member, described expansion member is combined with thrombosis tamper; Move described thrombosis tamper by described expansion member and enter into described suction chamber.
19. methods as claimed in claim 18, comprise further, are positioned at by described perfusing hole in described suction chamber to carry out fluid dynamic and macerate described thrombosis tamper.
20. methods as claimed in claim 18, comprise further, perfusion of fluid is filled into described suction chamber, wherein said suction chamber is closed by the thrombosis tamper of one or more expansion member or suction socket.
21. methods as claimed in claim 18, comprise further, handle described perfusion body and comprise and handle described perfusion body and move in described suction chamber together with the thrombosis tamper between expansion member to the suction socket making expansion member and be stuck in described catheter body at first.
22. 1 kinds of ejector filler systems comprise:
Shell, described shell maintains high-pressure pump, low-lift pump and suction module;
Wherein thrombectomy catheter is configured to be connected to high-pressure pump or low-lift pump;
Described high-pressure pump comprises further can with single piston pump of the pressure conveyance fluid between 5000psi to 10,000psi; And
Described low-lift pump comprises further can with the multiple-piston pump of the pressure conveyance fluid between 500psi to 1500psi.
23. ejector filler systems as claimed in claim 22, comprise the single piston pump configuring about 1500psi pump fluid further.
24. ejector filler systems as claimed in claim 22, are wherein configured to running independent of one another by described high-pressure pump and described low-lift pump.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2014/031299 WO2014127389A2 (en) | 2013-02-13 | 2014-03-20 | Thrombectomy catheter |
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| Publication Number | Publication Date |
|---|---|
| CN105120776A true CN105120776A (en) | 2015-12-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201480020975.9A Pending CN105120776A (en) | 2014-03-20 | 2014-03-20 | Thrombectomy catheter |
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| CN113350655A (en) * | 2016-02-24 | 2021-09-07 | 禾木（中国）生物工程有限公司 | Neurovascular catheter with enhanced flexibility |
| CN113350655B (en) * | 2016-02-24 | 2024-03-19 | 禾木（中国）生物工程有限公司 | Nerve vascular catheter with enhanced flexibility |
| CN107468306A (en) * | 2017-08-15 | 2017-12-15 | 南京普微森医疗科技有限公司 | A kind of thrombus suction catheter |
| US12042160B2 (en) | 2018-05-01 | 2024-07-23 | Incept, Llc | Catheter having angled tip |
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| US11766539B2 (en) | 2019-03-29 | 2023-09-26 | Incept, Llc | Enhanced flexibility neurovascular catheter |
| US11819228B2 (en) | 2019-12-18 | 2023-11-21 | Imperative Care, Inc. | Methods and systems for treating a pulmonary embolism |
| US11638637B2 (en) | 2019-12-18 | 2023-05-02 | Imperative Care, Inc. | Method of removing embolic material with thrombus engagement tool |
| US11633272B2 (en) | 2019-12-18 | 2023-04-25 | Imperative Care, Inc. | Manually rotatable thrombus engagement tool |
| US11553935B2 (en) | 2019-12-18 | 2023-01-17 | Imperative Care, Inc. | Sterile field clot capture module for use in thrombectomy system |
| CN111616802A (en) * | 2020-05-15 | 2020-09-04 | 上海交通大学 | Superfine magnetic control flexible robot based on high molecular polymer flexible microtubes |
| WO2023040232A1 (en) * | 2021-09-17 | 2023-03-23 | 深圳英美达医疗技术有限公司 | Multi-lumen tube having gradually changing hardness, manufacturing method, manufacturing apparatus, and endoscope |
| CN113876283A (en) * | 2021-09-17 | 2022-01-04 | 深圳英美达医疗技术有限公司 | Multi-cavity tube with gradually-changed hardness, manufacturing method and device and endoscope |
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