CN105106656A - Herbal composition pills with functions of activating blood, vanquishing toxin and eliminating tumor - Google Patents

Herbal composition pills with functions of activating blood, vanquishing toxin and eliminating tumor Download PDF

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CN105106656A
CN105106656A CN201510627744.0A CN201510627744A CN105106656A CN 105106656 A CN105106656 A CN 105106656A CN 201510627744 A CN201510627744 A CN 201510627744A CN 105106656 A CN105106656 A CN 105106656A
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tumor
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李玉强
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Abstract

Disclosed are an herbal composition with functions of activating blood, vanquishing toxin and eliminating tumor and its pills. The active ingredients of the pills include earthworm, safflower, pangolin scale, hairyvein agrimonia herb and bud, giant knotweed rhizome, pseudobulb of appendiculate Cremastra, baical skullcap root, Coptis root, lightyellow Sophora root, stiff silkworm, centipede, scorpion, cape jasmine fruit, Indian bread, whiteflower Patrinia herb, and root of Codonopsis pilosula. The pills have the effects of activating blood to eliminate tumor, clearing heat to cool blood, activating blood to eliminate stasis, clearing heat and toxin, strengthening body resistance and eliminating evil, and consolidating basis to restore yang. The pills are applicable to treating neurofibroma, scar fibroma, multiple fibromatosis, skin proliferation and multiple lipomas.

Description

A kind of Chinese medicine composition pill of dispersing tumor of relieving internal heat of invigorating blood circulation
Technical field
The invention belongs to tcm field, relate to a kind of have invigorate blood circulation, relieve internal heat, the Chinese medicine composition of dispersing tumor effect and the preparation and application of pill thereof.
Background technology
Tumor is a kind of disease common at present, and modern medicine is generally adopt the Therapeutic Method of doctor trained in Western medicine in the majority for the treatment of this type of disease, is divided into the modes such as the treatment of operative treatment, Drug therapy, x radiation x, immunotherapy.Better for infantile tumour effect, but complexity of performing the operation after all, oral administration and chemicotherapy to health toxic action greatly, directly injure inherent internal organs dirty, cause health to be sapped one's vitality.And treatment cycle is long, somewhat expensive, for a lot of people, bears very heavy.
Tumor is the gathering of the traditional Chinese medical science, the category such as lump in the abdomen, mass beside the umbilicus, rock.The pathogen and pathology of tcm of tumor is comparatively complicated.Be summarized as outside six climate exopathogens attack, internal injury caused by excess of seven emotions, imbalance of YIN and YANG, function are disorderly, QI-blood circulation is not normal, the turbid cohesion of expectorant, stagnation of blood stasis, accumulate in pyretic toxicity, healthy energy loss etc.Summarize with void, poison, expectorant, the stasis of blood four word.It is just thanks to its basic pathogenesis that the expectorant blood coagulation stasis of blood, poison accumulate, and six climate exopathogens, seven emotions, injury due to diet etc. are all the factors of directly or indirectly facilitating carcinoma.The Chinese medicine of tumor has long history in China, shows that the application of Chinese medicine has improve symptom according to a large amount of clinical and practical studies, improves life quality, extends life cycle, stablizes or reduce the effect of tumor and even elimination tumor.Chinese medicine does not singly play an important role in the auxiliary treatment of cancer also has direct antitumaous effect simultaneously.
The present invention inherits the multiple general plan of traditional medicine for tumor research and treatment, provide a kind of Chinese medicine composition and pill thereof, to various tumor effect all clearly, clinical practice is in the treatment of all kinds of each phase tumor, its effect can reduce lump in a short time, control is shifted, palliate the agonizing sufferings, stablize the state of an illness, extend life cycle, so that reaches clinical cure.
Technology contents
Think that tumor comes from the etiology and pathogenesis of void, poison, expectorant, the stasis of blood for the traditional Chinese medical science.Successive dynasties famous expert gives therapeutic scheme from different angles, Li Jiansheng [6]support with the kidney invigorating and be proficient in sharp method, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving disappear cancer method, replenishing QI to invigorate the spleen, anticancer method of regulating the flow of vital energy, and heat-clearing and toxic substances removing anticancer ruling by law treatment tumor obtains curative effect.Yi Juqing [7]thinking takes stopgap measures focuses on removing toxic substances and holds concurrently with heat clearing away, and effecting a permanent cure focuses on QI invigorating and be aided with yin nourishing, and dispersing tumor focuses on dissipating phlegm and resolving masses, helps with promoting flow of QI and blood, treating the poisonous disease with poisonous drugs.Liu Jiaxiang [8]advocate righting ruling by law and treat carcinoma, emphasize that supporting vital QI to relieve the primary cause of disease, both strengthening vital QI to eliminate pathogenic factors can not be attached undue importance to one thing to the neglect of the other, treatment must aim at the pathogenesis of disease focuses on spleen kidney, payes attention to invigorating the spleen and benefiting QI, the kidney warming sun, the methods such as nourishing kidney-yin.
The present invention in conjunction with clinical experience, has original compositions compatibility principle according to the theoretical case of famous doctor of Chinese Medicine, dialectical as follows: first, the generation of cancer, is namely the empty serious performance that declines of human righteousness." Ling Shu Miraculous Pivot or Divine Axis Ci Jiezhen evil " says: exogenous pathogen to enter body also dark, coldly fight mutually with heat, stay for a long time and interior work ... pathogen occupies anti-therebetween and not, sending out is nodular varicosity ... intestinal tumour ... former times tumor, the heavily fortified point pressed with hands.Also cloud in Li Zhongzi's its " Required Readings for Medical Professionals is always proved and controlled ": long-pending one-tenth person, positive QI-insufficiency, then pathogen crouches it.Whether closely related with the healthy energy power of people these generations all having explicitly pointed out tumor are.Therefore, in the treatment of tumor, space of top prominence should be placed on helping body healthy energy all the time.The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, and the nutrition of internal organs and the maintenance of function all need to rely on the transportation capabilities of taste normal, if the day after tomorrow, the source of vital function can not normal transporting, then anyly tonicly all can not play due effect.Chinese medicine composition of the present invention selects Poria, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Radix Codonopsis, invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.
Secondly, tumor poison be human body under multiple internal and external factor effect, visceral dysfunction and the specific pathologies factor that produces, in belonging to, raw poison is evil.Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " also carries: grandular plague person, has core inside suddenly, innumerable as prunus mume (sieb.) sieb.et zucc. Lee, little of beans ... this ailment said due to cold or exposure hold under the arm malicious become; Golden Mirror of Medicine is pointed out when describing the pathogeny of carbuncle malignant boil: all poisonous gas-tight plug meridians, and battalion defends stops up stagnant event.These illustrating evil poison is the key factor causing the malignant changes such as tumor.Tumor disease, no matter which kind of type, occur at it, in evolution, always have evil poison to gather, the pathogenesis of strongly fragrant heat-transformation of a specified duration.Therefore attack evil method suppression cancer poison with removing toxic substances, be method conventional in TCM on tumor treatment.The present invention selects Bombyx Batryticatus expelling wind for relieving convulsion, dissipating phlegm and resolving masses; Scorpio, Scolopendra endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Radix Scutellariae, heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive; Pseudobulbus Cremastrae Seu Pleiones, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses; Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication; Herba Patriniae, heat-clearing and toxic substances removing, removing blood stasis and expelling pus.
3rd, blood stasis is pathological product, is again paathogenic factor, in the process of its tumorigenesis, also serve as key player.Wang Qingren errors in Medicine Corrected is thought: gas is invisible can not lump, caking person, and tangible blood also; Tang Rongchuan " treatise on blood trouble " points out: blood stasis, between meridians internal organs, becomes lump in the abdomen; Height is held political power " Yangke Xinde Ji, Experience Gained in Treating External Diseases " also cloud: carcinoma person, non-negative and positive healthy energy is tied swollen, and being that the five internal organs blood stasis foul smell expectorant is stagnant forms.These all illustrate that tumor is for there being swollen body thing, how relevant with blood-stasis internal-depression, and hard or uneven, the sign of fixing blood agglomeration such as not moving, squamous and dry skin, body of the tongue purple is dim that clinical findings patient often has lump tactile.Therefore the treatment of tumor ought be method with blood circulation promoting and blood stasis dispelling.Chinese medicine composition of the present invention selects Flos Carthami, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; Herba Agrimoniae, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.
Finally, expectorant is that tumor is formed and important pathological product very important in generating process, and be again new paathogenic factor, can aggravate one's illness progress simultaneously.Tumor disease, occurs at it, in evolution, often have concurrently expectorant turbid in stop, the pathogenesis of the in bulk that condenses." Waike Zhengzong, Orthodox Manual of External Diseases " cloud: expectorant scrofula person, diet unbalanced cold and heat, hungry full irregular joy and anger, causing temper can not transport more, then becomes expectorant knot." ordinary person's body upper, middle and lower person's excessive phlegm that has block also for ZHU Dan-xi meaning." " ordinary person has tuberculosis bitterly not meciless with it, the person that do not do pus, and all phlegm-damp also." and call " expectorant for thing, fall with gas lift, nowhere less than ", therefore have saying of " all kinds of diseases and ailments all being haunted by expectorant ".Therefore in the treatment of tumor, answer that adapted dissipating phlegm and resolving masses is relievingd asthma, the medicine of pathogenic fire purging of dispeling the wind, Chinese medicine composition of the present invention selects Rhizoma Polygoni Cuspidati, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm; Squama Manis, detumescence and apocenosis, expel wind to dredge collateral; Pheretima, heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis; Radix Sophorae Flavescentis, heat clearing and damp drying, parasite killing, diuresis; Fructus Gardeniae, pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.
In sum, the object of this invention is to provide a kind of Chinese medicine composition of dispersing tumor and pill thereof of relieving internal heat of invigorating blood circulation, there is invigorating blood circulation tumor, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, heat clearing away toxin expelling, strengthening vital QI to eliminate pathogenic factors, consolidate the effect of returning to life from the nether world.Be adapted to the treatment of neurofibroma, cicatrix fibroma, multiple fibroma, skin hyperplasia, lipomatosis.
The present invention invigorates blood circulation the Chinese medicine composition pill of dispersing tumor of relieving internal heat, and is made up of: Pheretima, Flos Carthami, Squama Manis, Herba Agrimoniae, Rhizoma Polygoni Cuspidati, Pseudobulbus Cremastrae Seu Pleiones, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Bombyx Batryticatus, Scolopendra, Scorpio, Fructus Gardeniae, Poria, Herba Patriniae, Radix Codonopsis following active component.
The present invention invigorates blood circulation the medicine pill of dispersing tumor of relieving internal heat, its active medical material selected, and weight proportion is: Pheretima 20 parts, 10 parts, Flos Carthami, Squama Manis 10 parts, Herba Agrimoniae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, Pseudobulbus Cremastrae Seu Pleiones 30 parts, Radix Scutellariae 10 parts, Rhizoma Coptidis 3 parts, Radix Sophorae Flavescentis 6 parts, Bombyx Batryticatus 10 parts, Scolopendra 1 part, Scorpio 3 parts, Fructus Gardeniae 10 parts, 23 parts, Poria, Herba Patriniae 30 parts, Radix Codonopsis 10 parts.
The present invention invigorates blood circulation the medicine pill of dispersing tumor of relieving internal heat, and its preparation and application comprises following technology contents: (1) gets Pheretima, Flos Carthami, Squama Manis, Herba Agrimoniae, Rhizoma Polygoni Cuspidati, Pseudobulbus Cremastrae Seu Pleiones, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Bombyx Batryticatus, Scolopendra, Scorpio, Fructus Gardeniae, Poria, Herba Patriniae, Radix Codonopsis.Carry out concocting with reference to " Chinese Pharmacopoeia " 2010 editions contained modes, to dry, pulverize rear mistake 100 mesh sieve for subsequent use.(2) the rear Pheretima 20 parts of pulverizing is got, 10 parts, Flos Carthami, Squama Manis 10 parts, Herba Agrimoniae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, Pseudobulbus Cremastrae Seu Pleiones 30 parts, Radix Scutellariae 10 parts, Rhizoma Coptidis 3 parts, Radix Sophorae Flavescentis 6 parts, Bombyx Batryticatus 10 parts, Scolopendra 1 part, Scorpio 3 parts, Fructus Gardeniae 10 parts, 23 parts, Poria, Herba Patriniae 30 parts, Radix Codonopsis 10 parts is mixing fully, adopts ripening sterilization treatment, sterilizing 30 minutes, cooling, obtains preparing required pill medicated powder.(3) the high-purity Mel getting the weight such as prescription is put into when copper pot is brewed into moderate and above-mentioned medicated powder is dropped into pot, and stirred, cool, pill block after stirring, rub ball bar with the hands, pill grain, every ball weighs 6 grams.Consumption: every day 3 times, one time one, the course for the treatment of in January one.
The Chinese medicine composition pill that dispersing tumorization of the present invention is swollen, each component ratio, through fine setting for several times, defines comparatively clear and definite therapeutic combination.
The advantage of Chinese medicine composition of the present invention and pill thereof: six large advantages of Chinese traditional treatment tumor: 1, medicine source is enriched, and relative low price, most humans can accept.2, treating both the principal and secondary aspects of a disease, works along both lines, relieving internal heat tumor, improves autoimmunity, and effective symptom management development, life quality obviously improves, and extends life cycle.3, effectively relief of symptoms, palliate the agonizing sufferings rapidly.4, regulative mechanism, improves immunity of organisms, damage can drop to by the basis ensureing curative effect minimum, can not only play good effect over the course for the treatment of and can improve immunity of organisms fast.
Leading reference: [1] Dodd unit. the progress [J] of Treatment with TCM tumor. Liaoning Journal of Traditional Chinese Medicine, 2006,33 (12): 1655; [2] Lu Xiumei. the rationale of TCM on tumor and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs development [J]. Chinese Medicine guide, 2013,11 (3): 447; [3] Yang Zhu, old study. the pathogen and pathology of tcm pre-test [J] of tumor. Liaoning Journal of Traditional Chinese Medicine, 2002,29 (4): 197; [4] Zhang Zhonghai. the present situation of therapy of combining Chinese and Western medicine malignant tumor and before hold [J]. Shenzhen combination of Chinese and Western medicine magazine, 2003,13 (3): 129; [5] Gao Quanxin, the two residence of the chief of a tribe. Syndrome Differentiation of Chinese Medicine controls swollen lame clinical experience [J]. Shenzhen combination of Chinese and Western medicine magazine, 2001,11 (3): 161; [6] Shi Shuizhi, Li Jiansheng. treatment tumor science is thought to pardon pre-test [J]. Beijing Journal of Traditional Chinese Medicine, 2003,22 (2): 8; [7] broad-mouthed receptacle for holding liquid continues the people. and easily chrysanthemum is treated clearly and dislikes sad tumor experience [J]. Journal of Traditional Chinese Medicine, 2004,45 (2): 94; [8] Sun Jianli. Liu Jiaxiang treats malignant tumor discussion on scientific thoughts [J]. Liaoning Journal of Traditional Chinese Medicine, 2002,29 (7): 389; [9] CSC is strong. and Fang Baohua recuperates under medical treatment the experience [J] of oncosis. Zhejiang combination of Chinese and Western medicine magazine, 2005,15 (9): 551; [10] Li Weidong, Hua Baojin. different method for the treatment of general introduction [J] of Chinese medicine prevention tumor. Medical review, 2012,18 (2): 269; [11] Wu Dan, Li Hongzhi, Liu Jieting etc. treatment by Chinese herbs tumor research overview [J]. Mudanjiang Medical College's journal, 2011,32 (3): 72.
Clinical efficacy
1. sample information
Clinical sample from the various fibroma of diagnosis and treatment over several years, lipoma patient, total case 33 example.The oldest person 65 years old, reckling 24 years old.
2. criterion of therapeutical effect
According to the general inspection method of tumor, select ultrasonic examination.
Complete incidence graph: visual tumors disappears and continues January more than.
Partial rcsponse: the maximum orthogonal diameter product of two, tumor reduces more than 50% and continues January more than.
Stable: the maximum orthogonal diameter product of two, tumor reduces less than 50%, increases and is no more than 25% and continues more than one month.
Worsen: the maximum orthogonal diameter product of two, tumor increases above 25%.
3. Therapeutic Method
Take Chinese medicine composition pill of the present invention, every day 3 times, one time one, the course for the treatment of in January one.
4. model case
(1) Liu, female, 19 years old, Mianyang, Sichuan people from city.Lipomatosis, in Chengdu, the army make a definite diagnosis greatly, chemically examine, biopsy makes a definite diagnosis, used a lot of medicine in locality, traditional Chinese medical science doctor trained in Western medicine has all been controlled, and has little effect, and examines in March, 2014, has used this side to treat, a course for the treatment of, enclosed mass with now taking effect, enclosed mass deliquescing, little by 1/3rd.Used half a year continuously, 5 courses for the treatment of cure lipoma and have not thoroughly had.
(2) so-and-so is revived, man, 43 years old, Luonan County, Shaanxi Province, China people from county.In May, 2012 is diagnosed as multiple neurofibromatosis, and whole body has, and large has Fructus Jujubae so large, little is large as small rice grain, and large has more than 40, and little cannot count clearly, at Shaanxi medical college hospitalization, be diagnosed as multiple fibroma, doctor trained in Western medicine can only have been grown up excision, my the institute's medicine for treatment of rear and last Apr, first course for the treatment of just finds some atrophy of large fibroma, control 8 courses for the treatment of continuously to cure, beat fibroma and remove, do not recur so far.
(3) Liu so-and-so, man, Long Fang people from town, Huangling County, yan-an, suffers from solitary fibrous tumor, long to follow foot is naked, at Yan'an, the People's Hospital makes a definite diagnosis, and to perform an operation excision in 2006 in hospital of Shaanxi Province, less than 1 year, after in November, 2006 recurrence, long ratio was also beaten originally, examine in October, 2007, add hot application of Chinese medicine, the hot compress of Saigae Tataricae safflower soup with this side treatment, first course for the treatment of just obviously takes effect, shared and cured 5 courses for the treatment of, name patient and family members thereof bring a lot of local and special products to express thanks, and pay a return visit and do not recur.
Specific embodiment
(1) Pheretima, Flos Carthami, Squama Manis, Herba Agrimoniae, Rhizoma Polygoni Cuspidati, Pseudobulbus Cremastrae Seu Pleiones, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Bombyx Batryticatus, Scolopendra, Scorpio, Fructus Gardeniae, Poria, Herba Patriniae, Radix Codonopsis is got.Carry out concocting with reference to " Chinese Pharmacopoeia " 2010 editions contained modes, to dry, pulverize rear mistake 100 mesh sieve for subsequent use.
(2) the rear Pheretima 40 grams of pulverizing is got, 20 grams, Flos Carthami, Squama Manis 20 grams, Herba Agrimoniae 24 grams, Rhizoma Polygoni Cuspidati 24 grams, Pseudobulbus Cremastrae Seu Pleiones 60 grams, Radix Scutellariae 20 grams, Rhizoma Coptidis 6 grams, Radix Sophorae Flavescentis 12 grams, Bombyx Batryticatus 20 grams, Scolopendra 2 grams, Scorpio 6 grams, Fructus Gardeniae 20 grams, 46 grams, Poria, Herba Patriniae 60 grams, Radix Codonopsis 20 grams is mixing fully, adopts ripening sterilization treatment, sterilizing 30 minutes, cooling, obtains preparing required pill medicated powder.
(3) get 400 grams of high-purity Mel to put into when copper pot is brewed into moderate above-mentioned medicated powder is dropped into pot, stirred, cool, pill block after stirring, rub ball bar with the hands, pill grain, every ball weighs 6 grams.
Consumption: every day 3 times, one time one, the course for the treatment of in January one.

Claims (4)

1. to invigorate blood circulation the Chinese medicine composition of dispersing tumor and the pill thereof of relieving internal heat, it is characterized in that being made up of following active component: Pheretima, Flos Carthami, Squama Manis, Herba Agrimoniae, Rhizoma Polygoni Cuspidati, Pseudobulbus Cremastrae Seu Pleiones, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Bombyx Batryticatus, Scolopendra, Scorpio, Fructus Gardeniae, Poria, Herba Patriniae, Radix Codonopsis.
2. Chinese medicine composition as claimed in claim 1 and pill thereof, its active medical material selected, weight proportion is: Pheretima 20 parts, 10 parts, Flos Carthami, Squama Manis 10 parts, Herba Agrimoniae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, Pseudobulbus Cremastrae Seu Pleiones 30 parts, Radix Scutellariae 10 parts, Rhizoma Coptidis 3 parts, Radix Sophorae Flavescentis 6 parts, Bombyx Batryticatus 10 parts, Scolopendra 1 part, Scorpio 3 parts, Fructus Gardeniae 10 parts, 23 parts, Poria, Herba Patriniae 30 parts, Radix Codonopsis 10 parts.
3. Chinese medicine composition pill as claimed in claim 1, its preparation and application comprises following technology contents: (1) gets Pheretima, Flos Carthami, Squama Manis, Herba Agrimoniae, Rhizoma Polygoni Cuspidati, Pseudobulbus Cremastrae Seu Pleiones, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Bombyx Batryticatus, Scolopendra, Scorpio, Fructus Gardeniae, Poria, Herba Patriniae, Radix Codonopsis.Concoct, to dry, pulverize rear mistake 100 mesh sieve for subsequent use.(2) after measuring pulverizing by prescription, medical material powder fully mixes, and adopts ripening sterilization treatment, and cooling, obtains preparing required pill medicated powder.(3) the high-purity Mel getting the weight such as prescription is put into when copper pot is brewed into moderate and above-mentioned medicated powder is dropped into pot, is stirred, cools, pill block after stirring, rub ball bar with the hands, pill grain.
4. Chinese medicine composition as claimed in claim 1 and pill thereof, the application in neurofibroma, cicatrix fibroma, multiple fibroma, skin hyperplasia, lipomatosis treatment.
CN201510627744.0A 2015-09-29 2015-09-29 Herbal composition pills with functions of activating blood, vanquishing toxin and eliminating tumor Pending CN105106656A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108553585A (en) * 2018-04-23 2018-09-21 唐山福珍全民生药店有限公司 It is a kind of to treat lipoma and fibromatous Chinese medicine preparation and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘锋等: "《药物在左食物在右边》", 31 May 2008, 吉林科学技术出版社 *
赵建成等: "《肿瘤方剂大辞典》", 30 April 2009, 中医古籍出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108553585A (en) * 2018-04-23 2018-09-21 唐山福珍全民生药店有限公司 It is a kind of to treat lipoma and fibromatous Chinese medicine preparation and preparation method thereof

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Application publication date: 20151202