CN105080445B - A kind of is that template prepares method of the ferric tannate ionomer as the microcapsules of wall material using interfacial reaction using microemulsion - Google Patents
A kind of is that template prepares method of the ferric tannate ionomer as the microcapsules of wall material using interfacial reaction using microemulsion Download PDFInfo
- Publication number
- CN105080445B CN105080445B CN201510582586.1A CN201510582586A CN105080445B CN 105080445 B CN105080445 B CN 105080445B CN 201510582586 A CN201510582586 A CN 201510582586A CN 105080445 B CN105080445 B CN 105080445B
- Authority
- CN
- China
- Prior art keywords
- acid
- microcapsules
- oleic acid
- microemulsion
- wall material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Manufacturing Of Micro-Capsules (AREA)
Abstract
A kind of is that template prepares method of the ferric tannate ionomer as the microcapsules of wall material using interfacial reaction using microemulsion, the invention belongs to medical carrier, biomedical engineering and film engineering field, it is in order to solve the complex process that existing method prepares ferric tannate ionomer microcapsules, the problem of universality is poor.Preparation method：First, tannic acid solid is dissolved in deionized water, ultrasonically treated to obtain tannin aqueous acid；2nd, anhydrous ferric trichloride solid is placed in oleic acid-alcohol mixture, prepares oleic acid-ethanol-chlorination iron liquid miscella phase；3rd, tannin aqueous acid and oleic acid-ethanol-chlorination iron liquid miscella are mixed, and are carried out ultrasonically treated after vortex processing, are obtained this microcapsules.The present invention is combined using interfacial polymerization with template, using oleic acid as oil phase, simplifies the formation process of microcapsules, and obtained capsule universality is strong, can both encapsulate water soluble drug, can also encapsulate oil-soluble medicine.
Description
Technical field
The invention belongs to medical carrier, biomedical engineering and film engineering field, and in particular to one kind is with microemulsion droplets
For template, the method that microcapsules are prepared using interfacial reaction.
Background technology
Microcapsules refer to a kind of miniature vessel or packing material with polymeric shell wall, micro- with semi permeability or sealing
Small particles, wherein wrapped material is referred to as core, the material of parcel core is referred to as wall material.Tannic acid-Polymerization of Ferric Ions thing category
In a kind of supermolecule-metal ion polymer, the coordination ability of iron ion and phenolic hydroxyl group increases and strengthened with pH, with significant
PH response characteristics, are a kind of ideal materials as pH controlled release capsule wall materials.Preparing the main method of microcapsules at present has cohesion
Method, phase separation method, interfacial polymerization and soft template method etc..But the above method is not able to simply applied to applied widely
Tannic acid-iron ion microcapsules prepare, therefore, invent that a kind of yield is high, flow is simple, the preparation of universality by force is with tannin
Acid-Polymerization of Ferric Ions thing will have important meaning to the popularization of such microcapsules for the method for the pH controlled release capsules of wall material with application
Justice.
The content of the invention
The complex process of tannic acid-Polymerization of Ferric Ions thing microcapsules is prepared the invention aims to solve existing method,
The problem of universality is poor, and one kind is provided and prepares tannic acid-Polymerization of Ferric Ions thing using interfacial reaction by template of microemulsion
For the method for the microcapsules of wall material.
The present invention is that template prepares microcapsules of the tannic acid-Polymerization of Ferric Ions thing as wall material using interfacial reaction using microemulsion
Method follow these steps realize：
First, tannic acid solid is placed in deionized water, it is ultrasonically treated it is uniform after obtain tannin aqueous acid；
2nd, anhydrous ferric trichloride solid is weighed, is 10 by the mol ratio of oleic acid and anhydrous ferric trichloride:1~100:1 by nothing
Aqueous ferric chloride solid is placed in oleic acid, is 10 according still further to oleic acid and absolute ethyl alcohol volume ratio:1 adds at absolute ethyl alcohol, ultrasound
Oleic acid-ethanol-chlorination iron liquid miscella phase is obtained after reason is uniform；
3rd, oleic acid-ethanol that the tannin aqueous acid and step 2 obtained step one is obtained-chlorination iron liquid miscella
Mix, ultrasonically treated formation microemulsion, tannic acid and trivalent are carried out again after carrying out vortex processing, standing by vortex mixed instrument
In oil-water interfaces complex reaction occurs for iron ion, obtains the microcapsules using tannic acid-Polymerization of Ferric Ions thing as wall material.
The present invention relates to one kind using microemulsion droplets as template, the method that microcapsules are prepared using interfacial reaction.With tannin
The aqueous solution of acid is as aqueous phase, and oleic acid-ethanol-chlorination iron liquid miscella is as oil phase, by the ratio for adjusting oil and water
Through vortex mixed instrument and ultrasonically treated prepare oil-in-water or water-in-oil microemulsion again.The tannin in the forming process of microemulsion
Acid and ferric ion occur complex reaction in oil-water interfaces and formed in supermolecule-metal ion thin polymer film, cladding emulsion
Dispersed phase formation do not carry the soft template microcapsules of medicine.The loading of medicine can be dissolved in aqueous phase or oil phase by previously by medicine
It is middle to realize, can also be after removing template be removed by soaking realization.
The present invention is that template prepares microcapsules of the tannic acid-Polymerization of Ferric Ions thing as wall material using interfacial reaction using microemulsion
Method include advantages below：
1st, combined, be prepared into using microemulsion soft template with oil-water interfaces polymerisation with template using interfacial polymerization
Tannic acid-Polymerization of Ferric Ions thing microcapsules are arrived.
2nd, the main component that can dissolve the oleic acid of iron chloride as oil phase is employed, the formation work of microcapsules is simplified
Skill.It is also nutriment needed by human and oleic acid is not only nontoxic so that the more environmental protection of capsule formation process.
3rd, the capsule universality that the technique is prepared is strong, can both encapsulate water soluble drug, can also encapsulate oil-soluble
Medicine.
Brief description of the drawings
Fig. 1 is the electron microscope (microscope figure) for the oil-soluble medicine microcapsules that embodiment one is prepared；
Fig. 2 is the electron microscope (microscope figure) for the oil-soluble medicine microcapsules that embodiment two is prepared.
Embodiment
Embodiment one：Present embodiment prepares tannic acid-iron ion by template of microemulsion using interfacial reaction
Polymer follows these steps to realize for the method for the microcapsules of wall material：
First, tannic acid solid is placed in deionized water, it is ultrasonically treated it is uniform after obtain tannin aqueous acid；
2nd, anhydrous ferric trichloride solid is weighed, is 10 by the mol ratio of oleic acid and anhydrous ferric trichloride:1~100:1 by nothing
Aqueous ferric chloride solid is placed in oleic acid, is 10 according still further to oleic acid and absolute ethyl alcohol volume ratio:1 adds at absolute ethyl alcohol, ultrasound
Oleic acid-ethanol-chlorination iron liquid miscella phase is obtained after reason is uniform；
3rd, oleic acid-ethanol that the tannin aqueous acid and step 2 obtained step one is obtained-chlorination iron liquid miscella
Mix, ultrasonically treated formation microemulsion, tannic acid and trivalent are carried out again after carrying out vortex processing, standing by vortex mixed instrument
In oil-water interfaces complex reaction occurs for iron ion, obtains the microcapsules using tannic acid-Polymerization of Ferric Ions thing as wall material.
Preparation method described in present embodiment had both combined interfacial polymerization and template prepares the advantage of microcapsules, again
With simple to operate, reaction condition is gentle, reaction speed is fast, the features such as generation capsule size is uniform, enrich tannic acid-iron from
The preparation method of sub- polymer microcapsule.
Embodiment two：Present embodiment and the tannin sour water described in step one unlike embodiment one
The concentration of solution is 0.1~10mg/mL.Other steps and parameter are identical with embodiment one.
Embodiment three：Present embodiment and the tannin sour water described in step one unlike embodiment two
The concentration of solution is 0.5~5mg/mL.Other steps and parameter are identical with embodiment two.
Embodiment four：Present embodiment and the tannin sour water described in step one unlike embodiment two
The concentration of solution is 0.5~2mg/mL.Other steps and parameter are identical with embodiment two.
Embodiment five：Step 2 presses oleic acid unlike one of present embodiment and embodiment one to four
Mol ratio with anhydrous ferric trichloride is 10:1~20:1 is placed in anhydrous ferric trichloride solid in oleic acid, according still further to oleic acid and nothing
Water-ethanol volume ratio is 10:1 adds absolute ethyl alcohol.Other steps and parameter are identical with one of embodiment one to four.
Embodiment six：Described in step 2 unlike one of present embodiment and embodiment one to five
It is ultrasonically treated to be carried out at a temperature of 40 DEG C.Other steps and parameter are identical with one of embodiment one to five.
Embodiment seven：Step 3 presses tannin unlike one of present embodiment and embodiment one to six
The volume ratio of aqueous acid and oleic acid-iron chloride liquid complexes is (80~110):1 by tannin aqueous acid and oleic acid-second
Alcohol-chlorination iron liquid miscella is mixed.Other steps and parameter are identical with one of embodiment one to six.
Present embodiment obtains oil-in-water microemulsion.
Embodiment eight：Step 3 presses tannin unlike one of present embodiment and embodiment one to seven
The volume ratio of aqueous acid and oleic acid-ethanol-chlorination iron liquid miscella phase is 1:(80~110) by tannin aqueous acid with oil
Acid-iron chloride liquid complexes mixing.Other steps and parameter are identical with one of embodiment one to seven.
Present embodiment obtains water-in-oil microemulsion.
Embodiment nine：Described in step 3 unlike one of present embodiment and embodiment one to eight
It is ultrasonically treated to be carried out at a temperature of 25 DEG C.Other steps and parameter are identical with one of embodiment one to eight.
Embodiment one：The present embodiment prepares tannic acid-Polymerization of Ferric Ions thing by template of microemulsion using interfacial reaction
The method of the microcapsules of wall material follows these steps to realize：
First, tannic acid solid is placed in deionized water, obtained after being handled 5 minutes with 50W power ultrasonic at 25 DEG C
Concentration is 1mg/mL tannin aqueous acid；
2nd, anhydrous ferric trichloride solid is weighed, is 10 by the mol ratio of oleic acid and anhydrous ferric trichloride:1 by anhydrous trichlorine
Change iron solid to be placed in oleic acid, be 10 according still further to oleic acid and absolute ethyl alcohol volume ratio:1 add absolute ethyl alcohol, at 40 DEG C with
350W power ultrasonic obtains oleic acid-ethanol-chlorination iron liquid miscella phase after handling 30 minutes；
3rd, it is 1 according to the volume ratio of tannin aqueous acid and oleic acid-ethanol-chlorination iron liquid miscella phase:100 will be single
Peaceful aqueous acid is mixed with oleic acid-ethanol-chlorination iron liquid miscella, is vortexed by vortex mixed instrument and is handled 30s, is stood
With 50W power ultrasonic 5min formation water-in-oil microemulsions at 25 DEG C after 1min, tannic acid and ferric ion are in profit circle
The oil phase formation that face occurs in complex reaction, cladding emulsion is micro- using tannic acid-Polymerization of Ferric Ions thing as the oil-soluble medicine of wall material
Capsule.
The loading of water soluble drug：Water soluble drug is dissolved in cushioning liquid, then will be obtained by the present embodiment
Water-in-oil microemulsion is mixed with the aqueous solution of medicine, capsule is separated in lower floor's aqueous phase by centrifugal treating, the timing of immersion one
Between after centrifuge out capsule, be stored in cushioning liquid.
Embodiment two：The present embodiment prepares tannic acid-Polymerization of Ferric Ions thing by template of microemulsion using interfacial reaction
The method of the microcapsules of wall material follows these steps to realize：
First, tannic acid solid is placed in deionized water, obtained after being handled 5 minutes using 350W power ultrasonic concentration as
1mg/mL tannin aqueous acid；
2nd, anhydrous ferric trichloride solid is weighed, is 10 by the mol ratio of oleic acid and anhydrous ferric trichloride:1 by anhydrous trichlorine
Change iron solid to be placed in oleic acid, be 10 according still further to oleic acid and absolute ethyl alcohol volume ratio:1 adds at absolute ethyl alcohol, 40 DEG C with 350W
Power ultrasonic handle 30 minutes after obtain oleic acid-ethanol-chlorination iron liquid miscella phase；
3rd, it is 100 according to the volume ratio of tannin aqueous acid and oleic acid-ethanol-chlorination iron liquid miscella phase:1 will be single
Peaceful aqueous acid is mixed with oleic acid-ethanol-chlorination iron liquid miscella, is vortexed by vortex mixed instrument and is handled 30s, is stood
In oil-water interfaces complex reaction, cladding occur for ultrasound 5min formation oil-in-water microemulsion after 1min, tannic acid and ferric ion
Oil-soluble medicine microcapsules of the oil phase formation using tannic acid-Polymerization of Ferric Ions thing as wall material in emulsion.
The loading of oil-soluble medicine：Oil-soluble medicine is dissolved in ethanol, then the oil-in-water microemulsion that the present embodiment is formed
It is immersed in the ethanol solution of medicine 10 minutes, centrifugation isolates capsule in 3 minutes, is stored in pH=8.5 tris-HCl bufferings
In solution.
Claims (8)
1. a kind of is that template prepares tannic acid-Polymerization of Ferric Ions thing as the side of the microcapsules of wall material using interfacial reaction using microemulsion
Method, it is characterised in that be to realize according to the following steps：
First, tannic acid solid is placed in deionized water, it is ultrasonically treated it is uniform after obtain tannin aqueous acid；
2nd, anhydrous ferric trichloride solid is weighed, is 10 by the mol ratio of oleic acid and anhydrous ferric trichloride:1~100:1 by anhydrous three
Iron chloride solid is placed in oleic acid, is 10 according still further to oleic acid and absolute ethyl alcohol volume ratio:1 adds absolute ethyl alcohol, ultrasonically treated equal
Oleic acid-ethanol-chlorination iron liquid miscella phase is obtained after even；
3rd, oleic acid-ethanol that the tannin aqueous acid for obtaining step one is obtained with step 2-chlorination iron liquid miscella is mutually mixed
Close, vortex processing carried out by vortex mixed instrument, carry out ultrasonically treated formation microemulsion after standing again, tannic acid and ferric iron from
In oil-water interfaces complex reaction occurs for son, obtains the microcapsules using tannic acid-Polymerization of Ferric Ions thing as wall material；
The concentration of tannin aqueous acid wherein described in step one is 0.1~10mg/mL.
2. one kind according to claim 1 prepares tannic acid-Polymerization of Ferric Ions by template of microemulsion using interfacial reaction
Thing is the method for the microcapsules of wall material, it is characterised in that the concentration of the tannin aqueous acid described in step one is 0.5~5mg/mL.
3. one kind according to claim 2 prepares tannic acid-Polymerization of Ferric Ions by template of microemulsion using interfacial reaction
Thing is the method for the microcapsules of wall material, it is characterised in that the concentration of the tannin aqueous acid described in step one is 0.5~2mg/mL.
4. one kind according to claim 1 prepares tannic acid-Polymerization of Ferric Ions by template of microemulsion using interfacial reaction
Thing is the method for the microcapsules of wall material, it is characterised in that step 2 is 10 by the mol ratio of oleic acid and anhydrous ferric trichloride:1~
20:1 is placed in anhydrous ferric trichloride solid in oleic acid, is 10 according still further to oleic acid and absolute ethyl alcohol volume ratio:1 adds anhydrous second
Alcohol.
5. one kind according to claim 1 prepares tannic acid-Polymerization of Ferric Ions by template of microemulsion using interfacial reaction
Thing for the microcapsules of wall material method, it is characterised in that ultrasonically treated described in step 2 is carried out at a temperature of 40 DEG C.
6. one kind according to claim 1 prepares tannic acid-Polymerization of Ferric Ions by template of microemulsion using interfacial reaction
Thing is the method for the microcapsules of wall material, it is characterised in that step 3 is mixed by tannin aqueous acid with oleic acid-ethanol-chlorination iron liquid
The volume ratio for closing oil phase is (80~110):1 mixes tannin aqueous acid with oleic acid-ethanol-chlorination iron liquid miscella.
7. one kind according to claim 1 prepares tannic acid-Polymerization of Ferric Ions by template of microemulsion using interfacial reaction
Thing is the method for the microcapsules of wall material, it is characterised in that step 3 is mixed by tannin aqueous acid with oleic acid-ethanol-chlorination iron liquid
The volume ratio for closing oil phase is 1:(80~110) mix tannin aqueous acid with oleic acid-ethanol-chlorination iron liquid miscella.
8. one kind according to claim 1 prepares tannic acid-Polymerization of Ferric Ions by template of microemulsion using interfacial reaction
Thing for the microcapsules of wall material method, it is characterised in that ultrasonically treated described in step 3 is carried out at a temperature of 25 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510582586.1A CN105080445B (en) | 2015-09-14 | 2015-09-14 | A kind of is that template prepares method of the ferric tannate ionomer as the microcapsules of wall material using interfacial reaction using microemulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510582586.1A CN105080445B (en) | 2015-09-14 | 2015-09-14 | A kind of is that template prepares method of the ferric tannate ionomer as the microcapsules of wall material using interfacial reaction using microemulsion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105080445A CN105080445A (en) | 2015-11-25 |
| CN105080445B true CN105080445B (en) | 2017-08-25 |
Family
ID=54562311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510582586.1A Active CN105080445B (en) | 2015-09-14 | 2015-09-14 | A kind of is that template prepares method of the ferric tannate ionomer as the microcapsules of wall material using interfacial reaction using microemulsion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105080445B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2555658A (en) * | 2016-11-01 | 2018-05-09 | Cambridge Consultants | Microparticle production |
| IT201700030574A1 (en) * | 2017-03-20 | 2018-09-20 | Univ Degli Studi Di Roma “Tor Vergata” | New micro and nanocapsules of tannins useful for encapsulation and controlled release of active ingredients. |
| CN108522505A (en) * | 2018-06-08 | 2018-09-14 | 山东省花生研究所 | A kind of microcapsule suspending agent, preparation method and the application of S-metolachlor and AC 263222 |
| CN115151554A (en) * | 2019-10-07 | 2022-10-04 | 北卡罗来纳大学格林斯伯勒分校 | Synthesis of nano porous polyphenol-based coordination polymer framework and use method thereof |
| CN114029012A (en) * | 2021-08-25 | 2022-02-11 | 西湖大学 | Preparation method of microcapsule with metal organic coordination polymer as wall material |
| CN113750074B (en) * | 2021-09-10 | 2022-11-22 | 山东大学 | Novel acid-responsive ionic liquid microcapsule and preparation method and application thereof |
| CN115340427B (en) * | 2022-03-10 | 2023-04-11 | 南开大学 | Hematite-carboxymethyl cellulose-nutrient salt compound and preparation method and application thereof |
| CN115005225A (en) * | 2022-06-24 | 2022-09-06 | 贵州大学 | Illumination controlled-release abamectin microcapsule pesticide and preparation method thereof |
| CN115404048B (en) * | 2022-09-21 | 2024-06-11 | 东南大学 | Composite phase-change energy storage material and preparation method thereof |
| CN116569919A (en) * | 2023-04-26 | 2023-08-11 | 天津大学 | Responsive nano pesticide delivery system and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103691376A (en) * | 2013-12-24 | 2014-04-02 | 哈尔滨工业大学 | Method for preparing microcapsules by using oil in water micro-emulsion as template by means of layer-by-layer assembly technology |
| CN104381251A (en) * | 2014-10-31 | 2015-03-04 | 山东农业大学 | Pesticide microcapsule employing metal ion chelate of tannin as capsule wall and preparation method of pesticide microcapsule |
| CN104689772A (en) * | 2015-03-06 | 2015-06-10 | 天津大学 | Preparation method of polymer micro-capsules inspired by polyphenols chemistry |
-
2015
- 2015-09-14 CN CN201510582586.1A patent/CN105080445B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103691376A (en) * | 2013-12-24 | 2014-04-02 | 哈尔滨工业大学 | Method for preparing microcapsules by using oil in water micro-emulsion as template by means of layer-by-layer assembly technology |
| CN104381251A (en) * | 2014-10-31 | 2015-03-04 | 山东农业大学 | Pesticide microcapsule employing metal ion chelate of tannin as capsule wall and preparation method of pesticide microcapsule |
| CN104689772A (en) * | 2015-03-06 | 2015-06-10 | 天津大学 | Preparation method of polymer micro-capsules inspired by polyphenols chemistry |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105080445A (en) | 2015-11-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105080445B (en) | A kind of is that template prepares method of the ferric tannate ionomer as the microcapsules of wall material using interfacial reaction using microemulsion | |
| Lensen et al. | Polymeric microcapsules for synthetic applications | |
| CN105011343B (en) | A kind of intestinal-specific pH sensitiveness condenses microcapsule delivery system and preparation method and application again | |
| Hou et al. | Formulation of robust organic–inorganic hybrid magnetic microcapsules through hard-template mediated method for efficient enzyme immobilization | |
| CN107557055A (en) | A kind of preparation method of modified polyether crude oil rapid demulsifier | |
| CN102653704A (en) | Preparation method of small peppermint essence soft capsule taking calcium alginate as wall material | |
| CN104920639A (en) | Preparation method of peony seed oil microcapsule | |
| CN103203192A (en) | Nonionic reverse micelle system and method for modifying polar material by using same | |
| CN108837779A (en) | A kind of lignin microcapsules of ionomer and preparation method thereof | |
| CN102553470A (en) | Biological cellulose micro powder and application thereof | |
| CN103709447B (en) | A kind of magnetic cellulose composite microsphere and its production and use | |
| CN104801063A (en) | Supercritical extraction/micellization integrated device for lipophilic medicines in natural products | |
| CN101953817B (en) | Microcapsules with oil-soluble substances and preparation method thereof | |
| CN105817267A (en) | Aminopropyl solid base composite microsphere and preparation method thereof | |
| CN100491027C (en) | Method for preparing nano silver solution | |
| CA2408025A1 (en) | Method and facility for producing micromembrane capsules | |
| CN105533750A (en) | Oviductus ranae microcapsules and preparation method thereof | |
| CN108786749A (en) | Chitosan magnetic/diatomite composite material and preparation method thereof of As (V) in a kind of removable water | |
| Monshipouri et al. | Emulsification preparation of calcium alginate beads in the presence of sequesterant | |
| CN104829763B (en) | There is the preparation method of the organic/inorganic hybridization material POSS-PDMAEMA of temperature and pH-sensitivity | |
| CN204485822U (en) | A kind of reactor preparing microcapsule emulsion | |
| Ni et al. | Extraction of hexavalent chromium ions with polyurea microcapsules | |
| CN106890631A (en) | A kind of pH magnetic dual responsiveness dye sorbent, preparation method and applications | |
| CN205874275U (en) | Prepare sodium polyacrylat's device | |
| CN106881063A (en) | A kind of arsenic removal material and preparation method thereof and the application in rural groundwater arsenic removal |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |