CN105079034A - Preparation method of nasal nursing solution - Google Patents
Preparation method of nasal nursing solution Download PDFInfo
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- CN105079034A CN105079034A CN201510591709.8A CN201510591709A CN105079034A CN 105079034 A CN105079034 A CN 105079034A CN 201510591709 A CN201510591709 A CN 201510591709A CN 105079034 A CN105079034 A CN 105079034A
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Abstract
The invention relates to the technical field of a medical material, and in particular relates to a preparation method of a nasal nursing solution, wherein the preparation method comprises the following steps: 1. preparing physiological seawater; 2. filtering the physiological seawater obtained from the step 1 by virtue of a filter system; and 3. filling a filtered solution obtained from the step 2 by virtue of filling equipment and obtaining the nasal nursing solution through irradiation sterilization. Compared with the prior art, the preparation method disclosed by the invention has the following beneficial effects: the nasal nursing solution prepared by the nasal nursing solution preparation method disclosed by the invention, which contains the filtered physiological seawater solution which is rich in beneficial mineral substances and trace elements, has functions of sterilizing, diminishing inflammation and resisting allergy; and meanwhile, adverse reaction on babies, and in particular in infants, is avoided through filtration; and osmotic pressure and pH value of the nasal nursing solution are equal to or close to that of a nasal cavity, so that the technical problem of cleaning the nasal cavity is solved.
Description
Technical field
The present invention relates to medical material tech field, be specifically related to a kind of preparation method of nasal nursing liquid.
Background technology
Nasal cavity is the first bodyguard of respiratory system, air is before entering lung, will through the filtration of nose cilium, nasal membrane, harmful bacterial virus, dust impurities are filtered, and air humidity and temperature are adjusted to the degree of applicable pulmonary respiration, otherwise will cause serious harm to upper respiratory tract and lung, therefore say that the route nasal cavity of life starts also not to be to a certain extent.
Along with the development of commercial production and traffic, the content of the dust in air, smog increases, and the sickness rate of rhinitis constantly increases, and age of onset is also on a declining curve.Especially infant nasal cavity is grown not yet ripe, and nasal cavity is little, nasal mucosa rich blood vessel, easily causes nasal cavity inflammation or respiratory tract disease.As everyone knows, nose is the primary organ of human respiratory, be human respiratory and the Nature carry out mass exchange must through part, the temperature of the air not only regulating human body to suck and humidity, the harmful substances such as the dust simultaneously also in filtered air.Along with increasing the weight of of atmospheric pollution, the virulence factor such as the dust suspended in air, poisonous chemical particle, virus, antibacterial, mycete, anaphylactogen also rolls up.After these materials are inhaled into nasal cavity, nose utilizes the mechanism such as fibre swing, mucous secretion to block its major part in nasal cavity.As removed these harmful substances in nostril not in time, these harmful substances can stimulate nasal mucosa, cause discomfort, rhinorrhea, sneeze, nasal obstruction, inflammation or infection, threaten health, in the course of time, the generation of the diseases such as various acute and chronic rhinitis, sinusitis, allergic rhinitis, flu is caused.
Therefore, select applicable nasal cavity environment conditioning liquid for cleaning, that both nasal cavity can have been assembled causes a disease and dirt discharge, can reach bacteriostasis again, remove a large amount of anaphylactogen and antibacterial, virus and pus tears assembled in nasal cavity or even nasal sinuses.To the clean salubrious environment of one, nasal cavity, recovering the self-functions of expelling toxin of nasal cavity, is that the task of top priority needs solution difficult problem.China market is badly in need of applicable infant nasal cavity conditioning liquid for cleaning especially.At present, although nasal cavity cleaning health care adopts normal saline can play good cleaning effect as abluent usually, but it is gentle not when it acts on nasal cavity, in use procedure, the sense of discomfort of human body is stronger, as direct raw material, and there are some anaphylactogens in product employing sea salt, thermal source (some metabolites etc. produced by Marine microorganism) can produce untoward reaction to child especially baby in sea salt.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, provide one to make nasal cavity be in gentle shape body, the preparation method of the nasal nursing liquid that quality is more excellent.
To achieve these goals, the present invention adopts following technical scheme: the preparation method providing a kind of nasal nursing liquid, comprises the steps:
Step 1: prepare physiological seawater, the pH value of described physiological seawater is 6.0-8.0, and sodium chloride content is 8.5g/L-9.5g/L;
Step 2: step 1 gained physiological seawater is filtered through filtration system, obtains filtrate, described filtration system comprises primary filter and senior filter; Described primary filter comprises stainless steel filter and is placed in the filter element of stainless steel filter, and described filter element material is wood activated charcoal; Described senior filter comprises stainless steel filter and is placed in the first microporous filter membrane and second microporous filter membrane of stainless steel filter, and the aperture that retains of described first microporous filter membrane is 1 μm, and the aperture that retains of described second microporous filter membrane is 0.22 μm;
Step 3: carry out after fill by step 2 gained filtrate through filling apparatus, irradiation sterilization obtains nasal nursing liquid.
Preferably, in the preparation method of above-mentioned nasal nursing liquid, in the physiological seawater in described step 1, sodium chloride content is 9g/L, and pH value is 6.0.
Preferably, in the preparation method of above-mentioned nasal nursing liquid, the wood activated charcoal in described step 2 is cocoanut active charcoal.
Preferably, in the preparation method of above-mentioned nasal nursing liquid, also comprise osmotic pressure regulator in the physiological seawater in described step 1, osmotic pressure is 260mosm/Kg.
Preferably, in the preparation method of above-mentioned nasal nursing liquid, described osmotic pressure regulator be selected from boric acid, Borax, sodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, mannitol, ammonium sulfate, calcium phosphate one or more.
Preferably, in the preparation method of above-mentioned nasal nursing liquid, in the physiological seawater in described step 1, also antiseptic is comprised.
Preferably, in the preparation method of above-mentioned nasal nursing liquid, described antiseptic be selected from parabens, chlorobutanol, phenethanol, phenoxyethanol, sorbic acid, polyquaternary ammonium salt-1 one or more.
The present invention compared with prior art, beneficial effect is: the nasal nursing liquid that the preparation method of nasal nursing liquid of the present invention is obtained, containing the physiological seawater solution after filtration, containing abundant beneficial mineral matter and trace element in physiological seawater, sterilization, antiinflammatory, antianaphylactic effect can be played, simultaneously because filter, eliminate some impurity such as anaphylactogen, untoward reaction can not can be produced to child especially baby, its osmotic pressure and acid-base value equal or are similar to nasal cavity osmotic pressure and acid-base value, solve nasal cavity cleaning technical barrier.
Detailed description of the invention
By describing technology contents of the present invention in detail, being realized object and effect, be explained below in conjunction with embodiment.
The design of most critical of the present invention is: in the preparation method of nasal nursing liquid of the present invention, filter physiological sea brine, this product impurity is reduced greatly, reduces the zest to nasal cavity.
Embodiment 1
A preparation method for nasal nursing liquid, comprises the steps:
Step 1: prepare physiological seawater, described physiological seawater also comprises osmotic pressure regulator-boric acid and antiseptic-chlorobutanol.In described physiological seawater, sodium chloride content is 9g/L, and osmotic pressure is 260mosm/Kg, and pH value is 5.0;
Step 2: step 1 gained physiological seawater is filtered through filtration system, obtains filtrate, described filtration system comprises primary filter and senior filter; Described primary filter comprises stainless steel filter and is placed in the filter element of stainless steel filter, and described filter element material is cocoanut active charcoal; Described senior filter comprises stainless steel filter and is placed in the first microporous filter membrane and second microporous filter membrane of stainless steel filter, and the aperture that retains of described first microporous filter membrane is 1 μm, and the aperture that retains of described second microporous filter membrane is 0.22 μm;
Step 3: carry out after fill by step 2 gained filtrate through filling apparatus, irradiation sterilization obtains nasal nursing liquid.
Embodiment 2
A preparation method for nasal nursing liquid, comprises the steps:
Step 1: prepare physiological seawater, described physiological seawater also comprises osmotic pressure regulator-sodium hydrogen phosphate and antiseptic-phenoxyethanol.The pH value of described physiological seawater is 6.0, and osmotic pressure is 260mosm/Kg sodium chloride content is 8.5g/L;
Step 2: step 1 gained physiological seawater is filtered through filtration system, obtains filtrate, described filtration system comprises primary filter and senior filter; Described primary filter comprises stainless steel filter and is placed in the filter element of stainless steel filter, and described filter element material is cocoanut active charcoal; Described senior filter comprises stainless steel filter and is placed in the first microporous filter membrane and second microporous filter membrane of stainless steel filter, and the aperture that retains of described first microporous filter membrane is 1 μm, and the aperture that retains of described second microporous filter membrane is 0.22 μm;
Step 3: carry out after fill by step 2 gained filtrate through filling apparatus, irradiation sterilization obtains nasal nursing liquid.
Embodiment 3
A preparation method for nasal nursing liquid, comprises the steps:
Step 1: prepare physiological seawater, described physiological seawater also comprises osmotic pressure regulator-phenoxyethanol and antiseptic-chlorobutanol.Osmotic pressure is 260mosm/Kg, and pH value is 5.0.The pH value of described physiological seawater is 8.0, and sodium chloride content is 9.5g/L;
Step 2: step 1 gained physiological seawater is filtered through filtration system, obtains filtrate, described filtration system comprises primary filter and senior filter; Described primary filter comprises stainless steel filter and is placed in the filter element of stainless steel filter, and described filter element material is cocoanut active charcoal; Described senior filter comprises stainless steel filter and is placed in the first microporous filter membrane and second microporous filter membrane of stainless steel filter, and the aperture that retains of described first microporous filter membrane is 1 μm, and the aperture that retains of described second microporous filter membrane is 0.22 μm;
Step 3: carry out after fill through filling apparatus by step 2 gained filtrate, obtains nasal nursing liquid through cobalt-60 irradiation sterilization.
The various embodiments described above use checking through experimenter, occupation mode is: lavation, rinse, instil, any method entering nasal cavity such as spray, can be used for ewborn infant, child and adult's nasal cavity cleaning and nasal cavity moistening, improve the cleaning of acute, chronic, that drying property, atrophic, allergic rhinitis, sinusitis cause nasal cavity symptom and nasal cavity postoperative wound surface, recover nasal cavity function.
The nasal nursing liquid that the preparation method of above-mentioned nasal nursing liquid is obtained, containing the physiological seawater solution after filtration, have in physiological seawater containing abundant beneficial mineral matter and trace element, while sterilization, antiinflammatory, antianaphylactic effect can be played, it has carried out contaminant filter can not can produce untoward reaction to child especially baby, its osmotic pressure and acid-base value equal or are similar to nasal cavity osmotic pressure and acid-base value, solve nasal cavity cleaning technical barrier.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every equivalents utilizing description of the present invention to do, or be directly or indirectly used in relevant technical field, be all in like manner included in scope of patent protection of the present invention.
Claims (7)
1. a preparation method for nasal nursing liquid, is characterized in that, comprises the steps:
Step 1: prepare physiological seawater, the pH value of described physiological seawater is 6.0-8.0, and sodium chloride content is 8.5g/L-9.5g/L;
Step 2: step 1 gained physiological seawater is filtered through filtration system, obtains filtrate, described filtration system comprises primary filter and senior filter; Described primary filter comprises stainless steel filter and is placed in the filter element of stainless steel filter, and described filter element material is wood activated charcoal; Described senior filter comprises stainless steel filter and is placed in the first microporous filter membrane and second microporous filter membrane of stainless steel filter, and the aperture that retains of described first microporous filter membrane is 1 μm, and the aperture that retains of described second microporous filter membrane is 0.22 μm;
Step 3: carry out after fill by step 2 gained filtrate through filling apparatus, irradiation sterilization obtains nasal nursing liquid.
2. the preparation method of nasal nursing liquid according to claim 1, is characterized in that, in the physiological seawater in described step 1, sodium chloride content is 9g/L, and pH value is 6.0.
3. the preparation method of nasal nursing liquid according to claim 1, is characterized in that, the wood activated charcoal in described step 2 is cocoanut active charcoal.
4. the preparation method of nasal nursing liquid according to claim 1, is characterized in that, also comprises osmotic pressure regulator in the physiological seawater in described step 1, and osmotic pressure is 260mosm/Kg.
5. the preparation method of nasal nursing liquid according to claim 4, is characterized in that, described osmotic pressure regulator be selected from boric acid, Borax, sodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, mannitol, ammonium sulfate, calcium phosphate one or more.
6. the preparation method of nasal nursing liquid according to claim 1, is characterized in that, also comprises antiseptic in the physiological seawater in described step 1.
7. the preparation method of nasal nursing liquid according to claim 6, is characterized in that, described antiseptic be selected from parabens, chlorobutanol, phenethanol, phenoxyethanol, sorbic acid, polyquaternary ammonium salt-1 one or more.
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| CN201510591709.8A CN105079034A (en) | 2015-09-17 | 2015-09-17 | Preparation method of nasal nursing solution |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223626A (en) * | 2018-11-23 | 2019-01-18 | 黑龙江省科学院火山与矿泉研究所 | Wudalianchi cold spring mouth and nose nursing spray and preparation method thereof |
| CN109481429A (en) * | 2019-01-22 | 2019-03-19 | 广州蓓思语生物科技有限公司 | A kind of nasal nursing spray |
| CN109846985A (en) * | 2019-02-28 | 2019-06-07 | 浙江朗柯生物工程有限公司 | A kind of nasal cavity disease adjuvant treatment cleaning agent and preparation method thereof |
| CN111135141A (en) * | 2020-01-20 | 2020-05-12 | 蓝佳堂生物医药（福建）有限公司 | Preparation method of composite hydrogel for nasal cavity |
| CN112156073A (en) * | 2020-09-07 | 2021-01-01 | 厦门市壳聚糖生物科技有限公司 | Hydrogen-rich physiological seawater nasal spray and preparation method thereof |
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2015
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Patent Citations (3)
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| JP2013028583A (en) * | 2011-06-22 | 2013-02-07 | Kazunori Maeda | Washing liquid for nasal cavity and throat |
| CN103120703A (en) * | 2013-01-06 | 2013-05-29 | 王峥 | Care solution for cleaning nasal cavity and related composition |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223626A (en) * | 2018-11-23 | 2019-01-18 | 黑龙江省科学院火山与矿泉研究所 | Wudalianchi cold spring mouth and nose nursing spray and preparation method thereof |
| CN109481429A (en) * | 2019-01-22 | 2019-03-19 | 广州蓓思语生物科技有限公司 | A kind of nasal nursing spray |
| CN109846985A (en) * | 2019-02-28 | 2019-06-07 | 浙江朗柯生物工程有限公司 | A kind of nasal cavity disease adjuvant treatment cleaning agent and preparation method thereof |
| CN111135141A (en) * | 2020-01-20 | 2020-05-12 | 蓝佳堂生物医药（福建）有限公司 | Preparation method of composite hydrogel for nasal cavity |
| CN112156073A (en) * | 2020-09-07 | 2021-01-01 | 厦门市壳聚糖生物科技有限公司 | Hydrogen-rich physiological seawater nasal spray and preparation method thereof |
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Application publication date: 20151125 |