CN105061411A - Optical isomer 2S,4R,2'S-itraconazole crystal form, preparation method and applications thereof - Google Patents
Optical isomer 2S,4R,2'S-itraconazole crystal form, preparation method and applications thereof Download PDFInfo
- Publication number
- CN105061411A CN105061411A CN201510350844.3A CN201510350844A CN105061411A CN 105061411 A CN105061411 A CN 105061411A CN 201510350844 A CN201510350844 A CN 201510350844A CN 105061411 A CN105061411 A CN 105061411A
- Authority
- CN
- China
- Prior art keywords
- itraconazole
- optical isomer
- crystal formation
- preparation
- itraconazole crystal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510350844.3A CN105061411A (en) | 2015-06-23 | 2015-06-23 | Optical isomer 2S,4R,2'S-itraconazole crystal form, preparation method and applications thereof |
Applications Claiming Priority (1)
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CN201510350844.3A CN105061411A (en) | 2015-06-23 | 2015-06-23 | Optical isomer 2S,4R,2'S-itraconazole crystal form, preparation method and applications thereof |
Publications (1)
Publication Number | Publication Date |
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CN105061411A true CN105061411A (en) | 2015-11-18 |
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Family Applications (1)
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CN201510350844.3A Pending CN105061411A (en) | 2015-06-23 | 2015-06-23 | Optical isomer 2S,4R,2'S-itraconazole crystal form, preparation method and applications thereof |
Country Status (1)
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CN (1) | CN105061411A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106478615A (en) * | 2016-08-31 | 2017-03-08 | 山东罗欣药业集团股份有限公司 | A kind of Itraconazole crystal-form compound and preparation method thereof |
CN111603470A (en) * | 2020-07-01 | 2020-09-01 | 江苏艾迪药业股份有限公司 | Application of itraconazole isomer in preparation of drugs for treating squamous non-small cell lung cancer |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993019061A1 (en) * | 1992-03-18 | 1993-09-30 | Janssen Pharmaceutica N.V. | Itraconazole and saperconazole stereoisomers |
CN103191119A (en) * | 2013-04-03 | 2013-07-10 | 南京安赛莱医药科技有限公司 | Use of itraconazole in inhibiting of Akt kinase (protein kinase B) activity |
CN104774195A (en) * | 2015-03-10 | 2015-07-15 | 扬州艾迪生物科技有限公司 | Optically pure itraconazole key intermediate, synthetic method thereof, and method for synthesizing optically pure itraconazole from the intermediate |
CN104788437A (en) * | 2015-04-14 | 2015-07-22 | 扬州艾迪生物科技有限公司 | Method for chiral resolution of itraconazole |
-
2015
- 2015-06-23 CN CN201510350844.3A patent/CN105061411A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993019061A1 (en) * | 1992-03-18 | 1993-09-30 | Janssen Pharmaceutica N.V. | Itraconazole and saperconazole stereoisomers |
CN103191119A (en) * | 2013-04-03 | 2013-07-10 | 南京安赛莱医药科技有限公司 | Use of itraconazole in inhibiting of Akt kinase (protein kinase B) activity |
CN104774195A (en) * | 2015-03-10 | 2015-07-15 | 扬州艾迪生物科技有限公司 | Optically pure itraconazole key intermediate, synthetic method thereof, and method for synthesizing optically pure itraconazole from the intermediate |
CN104788437A (en) * | 2015-04-14 | 2015-07-22 | 扬州艾迪生物科技有限公司 | Method for chiral resolution of itraconazole |
Non-Patent Citations (1)
Title |
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WEI SHI,ET AL.: ""Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole"", 《ACS MED. CHEM. LETT.》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106478615A (en) * | 2016-08-31 | 2017-03-08 | 山东罗欣药业集团股份有限公司 | A kind of Itraconazole crystal-form compound and preparation method thereof |
CN106478615B (en) * | 2016-08-31 | 2019-08-13 | 山东罗欣药业集团股份有限公司 | A kind of Itraconazole crystal-form compound and preparation method thereof |
CN111603470A (en) * | 2020-07-01 | 2020-09-01 | 江苏艾迪药业股份有限公司 | Application of itraconazole isomer in preparation of drugs for treating squamous non-small cell lung cancer |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 225008 Liu Zhuang Road, Hanjiang District, Yangzhou, Jiangsu Province, No. 2 Applicant after: Jiangsu Aidi Pharmaceutical Co.,Ltd. Applicant after: NANJING ANSAILAI MEDICAL SCIENCE & TECHNOLOGY Co.,Ltd. Address before: 225008 Liu Zhuang Road, Hanjiang District, Yangzhou, Jiangsu Province, No. 2 Applicant before: JIANGSU AIDEA PHARMACEUTICAL CO.,LTD. Applicant before: NANJING ANSAILAI MEDICAL SCIENCE & TECHNOLOGY Co.,Ltd. Address after: 225008 Liu Zhuang Road, Hanjiang District, Yangzhou, Jiangsu Province, No. 2 Applicant after: JIANGSU AIDEA PHARMACEUTICAL CO.,LTD. Applicant after: NANJING ANSAILAI MEDICAL SCIENCE & TECHNOLOGY Co.,Ltd. Address before: 225008 VIP Road No. 2, Weiyang Economic Development Zone, Hanjiang District, Yangzhou, Jiangsu Applicant before: YANGZHOU AIDEA BIOTECH Co.,Ltd. Applicant before: NANJING ANSAILAI MEDICAL SCIENCE & TECHNOLOGY Co.,Ltd. |
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CB02 | Change of applicant information | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151118 |
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RJ01 | Rejection of invention patent application after publication |