CN105056385A - Electrode capable of carrying out simulation and collecting signal simultaneously and preparation method thereof - Google Patents
Electrode capable of carrying out simulation and collecting signal simultaneously and preparation method thereof Download PDFInfo
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- CN105056385A CN105056385A CN201510532596.4A CN201510532596A CN105056385A CN 105056385 A CN105056385 A CN 105056385A CN 201510532596 A CN201510532596 A CN 201510532596A CN 105056385 A CN105056385 A CN 105056385A
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Abstract
The invention relates to an electrode capable of carrying out simulation and collecting a signal simultaneously and a preparation method thereof. The electrode comprises a ground wire, a plurality of recording electrodes and a simulating electrode, wherein the ground wire, the recording electrodes and the simulating electrode are successively arranged. The ground wire is the longest; the simulating electrode is the shortest; and the recording electrode approaching the simulating electrode is shorter than those far away from the simulating electrode among the multiple recording electrodes. The multiple recording electrodes and one simulating electrode can simulate one nuclear group and signals of multiple nuclear groups can be recorded, so that the influences on the simulated nuclear group and the nuclear group adjacent to the simulated nuclear group by electric simulation can be reflected and correlated researches on multiple nuclear groups can be carried out simultaneously. Because the simulating electrode and the recording electrode contain insulating layers, the electrode can be placed in a tested animal body for long time without an electricity leakage phenomenon, so that the electrode is safe and durable.
Description
Technical field
The present invention is specifically related to a kind of can simultaneously stimulation and electrode of acquired signal and preparation method thereof.
Background technology
Electrode of the prior art is all generally that the electrode of stimulating electrode and acquired signal separates, and majority is all use glass microelectrode acquired signal, like this except testing inconvenience, the anesthesia signal of animal can only be gathered, in addition, existing electrode be all generally can only gather core group signal and multiple core group signal can not be gathered simultaneously, when a core group is stimulated, just can not accurately reflect by the reaction of the core group stimulating core to roll into a ball and to be adjacent, in addition, most electrode all can not stay in the body prolonged application, for the stimulating factor that some needs the long period to carry out observing, can not verify due to electrode damage, or sometimes need the test same animal being carried out to long-time different stimulated, capital failure because of the damage of electrode.
Although some electrode also has the electrode of multiple wire electrode in prior art, but the length of wire electrode is equal, and the effect of multiple wire electrode is not the signal recording different IPs group simultaneously, so, be difficult to have the electrode of multiple wire electrode to obtain wire electrode length of the present invention difference from of the prior art, and for recording the electrode of different IPs group signal.
Advantageous Effects of the present invention is:
1, multiple recording electrode and a stimulating electrode can accomplish stimulation core group, record the signal of multiple core group simultaneously, can reflect that electricity irritation rolls into a ball the impact of adjacent core group to irriate core group and irriate core like this, the correlation research of multiple core group can be carried out simultaneously.
2, the quality due to stimulating electrode is comparatively hard, can not bend, so stimulating electrode should be the shortest, last implantable stimulation electrode in use, the quality of recording electrode is softer, can be inserted in the core group of setting by bending, the length of recording electrode, by short elongated, is also based on this object.Near stimulating electrode recording electrode implant from irriate core group relatively close to core group in, so its length can be shorter, away from stimulating electrode recording electrode need implant from irriate core group away from core group in, so its length should be longer.
3, because stimulating electrode and recording electrode have insulating barrier, can in experimental animal body Preserving time, can not leak electricity, safety durable.
Summary of the invention
Object of the present invention is solve the technical problem existed in prior art, and providing a kind of can stimulate simultaneously and gather electrode of multiple core group signal and preparation method thereof.
In order to overcome the above problems, technical scheme of the present invention is:
A kind ofly can stimulate the electrode with acquired signal simultaneously, comprise earth lead, several recording electrodes and stimulating electrode, wherein, described earth lead is the longest, stimulating electrode is the shortest, is less than the length of the recording electrode away from stimulating electrode in several recording electrodes near the length of the recording electrode of stimulating electrode.
Ground wire is the wire for ground connection, i.e. the reference point of zero potential, needs to link animal body surface before bottom electrode, so its length needs all longer than any wire electrode.
Preferably, described recording electrode and stimulating electrode all scribble insulating barrier.
Preferably, described earth lead, recording electrode and stimulating electrode are all welded on single mother.These electrode wires are welded on single mother, can make each electrode arranged in rows, so not only facilitate the implantation of the electrode of different length, can also facilitate the production of this electrode.
Preferably, described recording electrode is nichrome wire, and the diameter of nichrome wire is 50-100 μm.Nichrome has good intensity and corrosion resistance, can extend electrode effective time in animal body, the recording electrode of this diameter, ensure enough intensity be implanted to animal core group basis on, alleviate as far as possible to animal core group infringement.
Preferably, described stimulating electrode is made up of rustless steel, and the diameter of stimulating electrode is 180-200 μm, and long is that 10mm. stimulating electrode quality is comparatively hard, and is last implantation, therefore the length slightly hypernucleus group degree of depth.
Preferably, described earth lead comprises insulated part and non-insulated portion.Insulated part serves as the wire in circuit, and the gong that non-insulated portion is wrapped in rat head has nailed on ground connection effect.
Preferably, several recording electrodes described comprise the first recording electrode, the second recording electrode and the 3rd recording electrode that are arranged in order, and the first recording electrode is adjacent with earth lead, and the 3rd recording electrode is adjacent with stimulating electrode.Three recording electrodes can record three core groups because stimulating the signal produced simultaneously, include irriate core group and roll into a ball adjacent core group with irriate core.
Preferred further, the length of the first recording electrode is 35-45mm, and the length of the second recording electrode is 25-35mm, and the length of the 3rd recording electrode is 15-25mm.After first recording electrode enters the degree of depth of core group in brain, need to fix with dental cement, part below stationary plane can not be moved again, but also will move the site that second recording electrode is rolled into a ball to second core, the total length guarantee remaining electrode that the wire electrode length above the electrode stationary plane fixed so previous will be longer than second electrode wires implants other core group smoothly.
The preparation method of described electrode, comprises the steps:
1) row intercepting preseting length is female, and earth lead, recording electrode and stimulating electrode are welded on row mother, the surface of recording electrode and stimulating electrode is all coated with insulating barrier;
2) carry out reinforcing and insulating with PUR butt welding contact, the thickness of PUR is greater than the female thickness of row, but is no more than 1mm with the difference of the female thickness of row, and the hot-melt width overlayed on row mother is no more than 1/4 of the female width of row.
Preferably, step 1) in, the coarse process in two sides that described row is female.Can the row of making mother combine with embedded material more firmly in embedding process.
Preferably, step 1) in, described stimulating electrode and the parallel welding of limb on row mother.That when guaranteeing implant electrode, stimulating electrode vertically can implant target like this.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Wherein, 1, earth lead, the 2, first recording electrode, the 3, second recording electrode, the 4, the 3rd recording electrode, 5, stimulating electrode, 6, PUR.
Detailed description of the invention
Below in conjunction with accompanying drawing and example, the present invention will be further described.
Embodiment 1
As shown in Figure 1, a kind ofly can stimulate the electrode with acquired signal simultaneously, comprise the earth lead 1, several recording electrodes and the stimulating electrode 5 that are arranged in order, wherein, described earth lead 1 is the longest, stimulating electrode 5 is the shortest, is less than the length away from stimulating electrode 5 in several recording electrodes near the length of the recording electrode of stimulating electrode 5.
Each recording electrode is nichrome wire, and the diameter of nichrome wire is 50-100 μm.
Stimulating electrode 5 is made up of rustless steel, and the diameter of stimulating electrode 5 is 180-200 μm, and long is 10mm.
Earth lead 1 comprises insulated part and non-insulated portion, and insulated part is welded on single mother.
Recording electrode comprise the first recording electrode 2, second recording electrode 3 of being arranged in order and the 3rd recording electrode 4, first recording electrode 2 adjacent with earth lead 1, the 3rd recording electrode 4 is adjacent with stimulating electrode 5.
The length of the first recording electrode is 40mm, and the length of the second recording electrode is 30mm, and the length of the 3rd recording electrode is 20mm.
The number of recording electrode also can be 1,2,3,4 or multiple, and the length difference of adjacent recording electrode is 10mm, and the length of earth lead will be longer than the length of the longest recording electrode.
Embodiment 2
The arrangement of stimulating electrode of the present invention, recording electrode and earth lead also can be: stimulating electrode 5 is arranged on centre, recording electrode is arranged around stimulating electrode 5, earth lead is arranged on outermost end, the length of stimulating electrode 5 is the shortest, near the length being shorter in length than the recording electrode away from stimulating electrode 5 of the recording electrode of stimulating electrode 5.
The preparation method of described electrode, comprises the steps:
1) row intercepting preseting length is female, the two sides coarse process female by row, by on earth lead, recording electrode and the stimulating electrode successively row of being welded on mother, stimulating electrode and the parallel welding of limb on row mother, the surface of recording electrode and stimulating electrode is all coated with insulating barrier;
2) carry out reinforcing and insulating with PUR 6 butt welding contact, the thickness of PUR is not more than the female thickness 1mm of row, and the hot-melt width overlayed on row mother is no more than 1/4 of the female width of row.
By reference to the accompanying drawings the specific embodiment of the present invention is described although above-mentioned; but the restriction not to invention protection domain; one of ordinary skill in the art should be understood that; on the basis of technical scheme of the present invention, those skilled in the art do not need to pay various amendment or distortion that creative work can make still in protection scope of the present invention.
Claims (10)
1. one kind can stimulate the electrode with acquired signal simultaneously, it is characterized in that: comprise the earth lead, several recording electrodes and the stimulating electrode that are arranged in order, wherein, described earth lead is the longest, stimulating electrode is the shortest, is less than the length away from stimulating electrode in several recording electrodes near the length of the recording electrode of stimulating electrode.
2. the electrode of stimulation and acquired signal simultaneously according to claim 1, is characterized in that: described earth lead, recording electrode and stimulating electrode are all welded on single mother, and recording electrode and stimulating electrode all scribble insulating barrier.
3. the electrode of stimulation and acquired signal simultaneously according to claim 1, it is characterized in that: each recording electrode is nichrome wire, the diameter of nichrome wire is 50-100 μm.
4. the electrode of stimulation and acquired signal simultaneously according to claim 1, it is characterized in that: described stimulating electrode is made up of rustless steel, the diameter of stimulating electrode is 180-200 μm, and long is 10mm.
5. the electrode of stimulation and acquired signal simultaneously according to claim 1, it is characterized in that: described earth lead comprises insulated part and non-insulated portion, insulated part is welded on row mother.
6. the electrode of stimulation and acquired signal simultaneously according to claim 1, it is characterized in that: several recording electrodes described comprise the first recording electrode, the second recording electrode and the 3rd recording electrode that are arranged in order, first recording electrode is adjacent with earth lead, and the 3rd recording electrode is adjacent with stimulating electrode.
7. the electrode of stimulation and acquired signal simultaneously according to claim 6, it is characterized in that: the length of the first recording electrode is 35-45mm, the length of the second recording electrode is 25-35mm, and the length of the 3rd recording electrode is 15-25mm.
8. claim 1-7 arbitrary described while stimulate and the preparation method of electrode of acquired signal, comprise the steps:
1) row intercepting preseting length is female, and by earth lead, recording electrode and the stimulating electrode successively row of being welded on mother, the surface of recording electrode and stimulating electrode all scribbles insulating barrier;
2) carry out reinforcing and insulating with PUR butt welding contact, the thickness of PUR is greater than the female thickness of row, and the thickness of PUR is no more than 1mm with the difference of the female thickness of row, and the hot-melt width overlayed on row mother is no more than 1/4 of the female width of row.
9. the preparation method of the electrode of stimulation and acquired signal simultaneously according to claim 8, is characterized in that: step 1) in, the coarse process in two sides of described single mother.
10. the preparation method of the electrode of stimulation and acquired signal simultaneously according to claim 1, is characterized in that: step 1) in, the welding parallel with the limb on single mother of described stimulating electrode.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510532596.4A CN105056385B (en) | 2015-08-26 | 2015-08-26 | It is a kind of to stimulate and gather simultaneously electrode of signal and preparation method thereof |
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| CN201510532596.4A CN105056385B (en) | 2015-08-26 | 2015-08-26 | It is a kind of to stimulate and gather simultaneously electrode of signal and preparation method thereof |
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| CN105056385B CN105056385B (en) | 2017-11-07 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105852855A (en) * | 2016-04-15 | 2016-08-17 | 郑州科斗创客科技有限公司 | Implantable cerebral electrode for measuring cerebral primary visual electrocorticograms in rodents |
| CN106983953A (en) * | 2017-04-21 | 2017-07-28 | 浙江中医药大学 | A kind of microfilament array electrode being implanted into suitable for experimental rat encephalic and preparation method thereof |
| CN109528191A (en) * | 2018-11-05 | 2019-03-29 | 山东师范大学 | A kind of encephalic Electroencephalo signal detection and amplification system and method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755691A (en) * | 2012-06-19 | 2012-10-31 | 吉林大学 | Medical high-sensitivity micro needle array electrode |
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2015
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755691A (en) * | 2012-06-19 | 2012-10-31 | 吉林大学 | Medical high-sensitivity micro needle array electrode |
Non-Patent Citations (2)
| Title |
|---|
| 丁方香: "深部脑刺激在探究束旁核和内侧苍白球的联系中的应用", 《中国优秀硕士学位论文全文数据库医药卫生科技辑2013年》 * |
| 路致: "深部脑刺激对帕金森病大鼠运动皮层放电的影响", 《中国优秀硕士学位论文全文数据库医药卫生科技辑2013年》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105852855A (en) * | 2016-04-15 | 2016-08-17 | 郑州科斗创客科技有限公司 | Implantable cerebral electrode for measuring cerebral primary visual electrocorticograms in rodents |
| CN106983953A (en) * | 2017-04-21 | 2017-07-28 | 浙江中医药大学 | A kind of microfilament array electrode being implanted into suitable for experimental rat encephalic and preparation method thereof |
| CN109528191A (en) * | 2018-11-05 | 2019-03-29 | 山东师范大学 | A kind of encephalic Electroencephalo signal detection and amplification system and method |
| CN109528191B (en) * | 2018-11-05 | 2021-08-17 | 山东师范大学 | Intracranial electroencephalogram physiological signal detection and amplification system and method |
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| CN105056385B (en) | 2017-11-07 |
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