CN105054980A - Self-adaptive variable angle plugging device - Google Patents
Self-adaptive variable angle plugging device Download PDFInfo
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- CN105054980A CN105054980A CN201510578225.XA CN201510578225A CN105054980A CN 105054980 A CN105054980 A CN 105054980A CN 201510578225 A CN201510578225 A CN 201510578225A CN 105054980 A CN105054980 A CN 105054980A
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- connector
- fixedly connected
- shutoff
- shutoff dish
- self adaptation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00606—Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
Abstract
The invention provides a self-adaptive variable angle plugging device which comprises an upper plugging plate and a lower plugging plate. The plugging device is characterized in that the upper plugging plate and the lower plugging plate are connected through a rotatable connecting structure. The upper plugging plate and the lower plugging plate are planes, or one side of the plugging plate located at the upper side is turned over and buckled downwards, or the periphery side of the plugging plate located at the upper side is turned over and buckled downwards. As the variable angle connecting mode is adopted, when matched with a lack portion, the plugging device can select the most suitable connecting position in a self-adaptive mode, and fit the organization portion better, and the optimal plugging effect is achieved.
Description
Technical field
The present invention relates to one can self adaptation varied angle stopper, is used in treatment atrial septal defect atrial septal defect (ASD), patent ductus arteriosus (PDA), ventricular septal defect (VSD) or patent foramen ovale (PFO).
Background technology
On market, conventional stopper uses the ligation of ligation steel bushing by NiTi tubular reticulum two ends, is made up of two plate-likes and column coupling part, and the plate-like of conventional stopper and support waist are the network structure of one.For the defect that both sides thin and thick differs greatly, it is limited thus do not reach good plugging effect to there is angle of inclination in conventional stopper, and follow-up residual shunt phenomenon usually needs additionally to place a stopper to realize plugging effect.This not only adds metal implantation amount and the operation technique difficulty of stopper, stopper more easily comes off simultaneously, and patient treatment expense significantly increases in addition.
Summary of the invention
The object of this invention is to provide one can self adaptation varied angle stopper, and it can the most suitable link position of adaptive selection when stopper mates with defect, thus reaches optimum plugging effect.
In order to achieve the above object, the invention provides one can self adaptation varied angle stopper, comprises upper and lower two shutoff dishes, it is characterized in that, connected between described upper and lower two shutoff dishes by rotatable syndeton.
Preferably, described upper and lower two shutoff dishes are plane, or the middle part being positioned at the shutoff dish of upside bends downwards, or the neighboring of the shutoff dish on the upside of being positioned at is turned over downwards and buckled.
Preferably, described rotatable syndeton comprises the first connector, the second connector, the first described connector is fixedly connected with the lower card of upper shutoff dish, second connector is fixedly connected with the upper disk surface of lower shutoff dish, the first described connector has a spherical lower end, and this spherical lower end adopts rotatable mode to be located in the top of the second connector.
More preferably, the first described connector comprises first component and second component, and described first component is fixedly connected with the lower card of upper shutoff dish, and the upper end of second component is fixedly connected with first component, and the lower end of second component is spherical; The second described connector comprises cylindrical body, the lower end of cylindrical body is fixedly connected with the upper disk surface of lower shutoff dish, the top inwall of cylindrical body has annular projection, the spherical lower end of described second component is limited in the top of cylindrical body by this annular projection, locating part is provided with in described cylindrical body, the upper end of locating part has hemispherical groove, and the spherical lower end of described second component adopts rotatable mode to be located in described hemispherical groove.
Preferably, described rotatable syndeton comprises the first connector, the second connector, the first described connector is fixedly connected with the lower card of upper shutoff dish, second connector is fixedly connected with the upper disk surface of lower shutoff dish, the lower end of the first connector is located at by bearing pin in the upper end of the second connector, and the first connector can rotate around described bearing pin.
Preferably, described rotatable syndeton comprises the first connector, the second connector, the first described connector is fixedly connected with the lower card of upper shutoff dish, second connector is fixedly connected with the upper disk surface of lower shutoff dish, the lower end of the first connector is connected with connecting filament, described connecting filament is located in the upper end of the second connector by bearing pin, and the first connector can rotate around described bearing pin via connecting filament.
Preferably, described rotatable syndeton comprises the first connector, the second connector, the first described connector is fixedly connected with the lower card of upper shutoff dish, second connector is fixedly connected with the upper disk surface of lower shutoff dish, the lower end of the first connector is connected with connecting filament, and described connecting filament connects the second connector.
Preferably, described upper and lower two shutoff dishes are all woven by nitinol alloy wire and form.
Preferably, the shutoff dish being positioned at upside adopts nitinol alloy wire to close up, and does not arrange steel bushing.
Preferably, the shutoff dish being positioned at downside is provided with the threaded steel bushing that can be connected with screw thread push rod.
Preferably, at least one inside in described upper and lower two shutoff dishes has been provided with the macromolecule choked flow film of blocking blood flow effect.
Compared with prior art, the invention has the beneficial effects as follows:
1, the present invention's connected mode of adopting upper and lower two shutoff dish angles variable, can the most suitable link position of adaptive selection when stopper mates with defect, tissue site of more fitting, thus reaches optimum plugging effect;
2, the present invention buckles design by turning over of upper shutoff dish, further improves plugging effect;
3, stopper of the present invention is fixed, is not easy to come off, and without the need to additionally placing a stopper, blocking residual shunt, decreasing operating difficulty, alleviates the misery of patient simultaneously.
4, the present invention is easy and simple to handle, identical with the using method of existing stopper.
Accompanying drawing explanation
Fig. 1 a is can self adaptation varied angle stopper structural representation;
Fig. 1 b is the syndeton schematic diagram in embodiment 2;
Fig. 2 a is the upper shutoff dish structural representation without steel bushing design;
Fig. 2 b be upper shutoff dish without steel bushing design can self adaptation varied angle stopper structural representation;
Fig. 3 a is can self adaptation varied angle stopper using state figure;
Fig. 3 b is that the syndeton in embodiment 1 rotates schematic diagram;
Fig. 4 be have that neighboring turns over the upper shutoff dish of button downwards can self adaptation varied angle stopper structural representation;
Fig. 5 a be upper shutoff dish side turn over downwards buckle can self adaptation varied angle stopper structural representation;
Fig. 5 b is the upper shutoff dish structural representation of middle part bending downwards;
What Fig. 6 bent downwards in the middle part of being can use schematic diagram by self adaptation varied angle stopper;
Fig. 7 a is the syndeton schematic diagram in embodiment 3;
Fig. 7 b is the syndeton schematic diagram in embodiment 4;
Fig. 7 c is the syndeton schematic diagram in embodiment 5;
Fig. 8 is the manufacturing process figure of syndeton;
Fig. 9 is stopper sizing schematic diagram;
Figure 10 is stereotyped stopper schematic diagram.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of invention to limit the scope of the invention.In addition should be understood that those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after the content of having read the present invention's instruction.
Embodiment 1
As shown in Figure 2 b, the present embodiment can self adaptation varied angle stopper, comprise upper and lower two shutoff dishes 1, between described upper and lower two shutoff dishes 1, rotatable syndeton 2 connects.Described upper and lower two shutoff dishes 1 are all woven by nitinol alloy wire and form, and described upper and lower two shutoff dishes 1 are planar structure.As shown in Figure 2 a, the shutoff dish 1 being positioned at upside adopts nitinol alloy wire to close up, and does not arrange steel bushing.The shutoff dish 1 being positioned at downside is provided with the threaded steel bushing 4 that can be connected with screw thread push rod.
As shown in Figure 3 b, described rotatable syndeton 2 comprises the first connector 11, second connector 12, the first described connector 11 is fixedly connected with the lower card of upper shutoff dish 1, second connector 12 is fixedly connected with the upper disk surface of lower shutoff dish 2, the first described connector 11 has a spherical lower end, and this spherical lower end adopts rotatable mode to be located in the top of the second connector 12.
As shown in Figure 8, the concrete structure of described rotatable syndeton 2 is: the first described connector 11 comprises first component 111 and second component 112, described first component 111 is fixedly connected with the lower card of upper shutoff dish 1, the upper end of second component 112 is fixedly connected with first component 111, and the lower end of second component 112 is spherical; The second described connector 12 comprises cylindrical body 121, the lower end of cylindrical body 121 is fixedly connected with the upper disk surface of lower shutoff dish 2, the top inwall of cylindrical body 121 has annular projection 123, the spherical lower end of described second component 112 is limited in the top of cylindrical body 121 by this annular projection 123, locating part 122 is provided with in described cylindrical body 121, the upper end of locating part 122 has hemispherical groove, and the spherical lower end of described second component 112 adopts rotatable mode to be located in described hemispherical groove.During making, the spherical lower end of second component 112 is snapped in cylindrical body 121, locating part 122 is inserted and carries out spacing to the spherical lower end of second component 112 in cylindrical body 121, then second component 112 is connected with first component 111.
The present embodiment can the manufacturing process of self adaptation varied angle stopper be, Nitinol is carried out on mould be woven into silk screen, heat treatment shaping, silk screen is taken off from mould, the upper port being positioned at the shutoff dish 1 of upside adopts nitinol alloy wire to close up, lower port is fixedly connected with the first connector 11 of rotatable syndeton 2, the upper port of the shutoff dish 1 being positioned at downside is fixedly connected with the second connector 12, lower port is fixedly connected with threaded steel bushing 4, and after the first connector 11 is connected with the second connector 12, as shown in Figure 9, silk screen is loaded in shaper 15, again heat-treat, obtain as shown in Figure 10 can self adaptation varied angle stopper, upper, the macromolecule choked flow film of blocking blood flow effect has been sewed up in lower two shutoff dishes 1.
During use, screw thread push rod is connected threaded steel bushing 4, after this stopper is drawn in short sheath, short sheath is connected with long sheath, then this stopper is sent into long sheath, defect is delivered to along long sheath, release upside shutoff dish 1 after withdraw, until downside shutoff dish 1 by defect after discharge downside shutoff dish 1.Pulling stopper gently makes stopper be adapted to optimum position, and adaptively can become shape as shown in Figure 3 a when running into the defect that both sides thin and thick differs greatly, syndeton rotates as shown in Figure 3 b.Then rotate push rod by the screw of push rod head end, push rod to be separated with stopper.Now stopper plays the effect stopping blood flow in defect, thus plays therapeutical effect.
Embodiment 2
As seen in figure la and lb, can be similar to embodiment 1 by self adaptation varied angle stopper in the present embodiment, difference is, the described upper port being positioned at the shutoff dish 1 of upside adopts steel bushing 3 to fetter.
Embodiment 3
As shown in Figure 4, embodiment 1 can be similar to by self adaptation varied angle stopper in the present embodiment, difference is: the neighboring of the shutoff dish 1 on the upside of being positioned at is turned over downwards and buckled, and this design can ensure that in the process of change shutoff, shutoff dish 1 can tightly be adjacent to defect perienchyma up and down.
Embodiment 4
As shown in Figure 5 a, embodiment 1 can be similar to by self adaptation varied angle stopper in the present embodiment, difference is: the shutoff dish 1 (be stressed less side) being positioned at downside is planar design, the middle part being positioned at the shutoff dish 1 of upside bends downwards, form two parts in left and right, left half is parallel with the shutoff dish 1 place plane being positioned at downside, and right half is downward-sloping, and the structure of this shutoff dish 1 as shown in Figure 5 b.
During use, as shown in Figure 6, shape as shown in Figure 6 adaptively can be become when running into the defect that both sides thin and thick differs greatly.
Embodiment 5
Embodiment 1 can be similar to by self adaptation varied angle stopper in the present embodiment, difference is: as shown in Figure 7a, the concrete structure of described rotatable syndeton is different, the rotatable syndeton of the present embodiment comprises the first connector 11, second connector 12, the first described connector 11 is fixedly connected with the lower card of upper shutoff dish 1, second connector 12 is fixedly connected with the upper disk surface of lower shutoff dish 2, the lower end of the first connector 11 is located at by bearing pin 13 in the upper end of the second connector 12, and the first connector 11 can rotate around described bearing pin 13.
Embodiment 6
Embodiment 1 can be similar to by self adaptation varied angle stopper in the present embodiment, difference is: as shown in Figure 7b, the concrete structure of described rotatable syndeton is different, the rotatable syndeton of the present embodiment comprises the first connector 11, second connector 12, the first described connector 11 is fixedly connected with the lower card of upper shutoff dish 1, second connector 12 is fixedly connected with the upper disk surface of lower shutoff dish 2, the lower end of the first connector 11 is connected with connecting filament 14, described connecting filament 14 is located in the upper end of the second connector 12 by bearing pin 13, first connector 11 can rotate around described bearing pin 13 via connecting filament 14.
Embodiment 1 can be similar to by self adaptation varied angle stopper in the present embodiment, difference is: as shown in Figure 7b, the concrete structure of described rotatable syndeton is different, the rotatable syndeton of the present embodiment comprises the first connector 11, second connector 12, the first described connector 11 is fixedly connected with the lower card of upper shutoff dish 1, second connector 12 is fixedly connected with the upper disk surface of lower shutoff dish 2, the lower end of the first connector 11 is connected with connecting filament 14, and described connecting filament 14 connects the second connector 12.
Claims (10)
1. can a self adaptation varied angle stopper, comprise upper and lower two shutoff dishes (1), it is characterized in that, connected by rotatable syndeton (2) between described upper and lower two shutoff dishes (1).
2. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, described upper and lower two shutoff dishes (1) are plane, or, the middle part being positioned at the shutoff dish (1) of upside bends downwards, or the neighboring of the shutoff dish (1) on the upside of being positioned at is turned over downwards and is buckled.
3. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, described rotatable syndeton (2) comprises the first connector (11), the second connector (12), described the first connector (11) is fixedly connected with the lower card of upper shutoff dish (1), second connector (12) is fixedly connected with the upper disk surface of lower shutoff dish (2), described the first connector (11) has a spherical lower end, and this spherical lower end adopts rotatable mode to be located in the top of the second connector (12).
4. as claimed in claim 2 can self adaptation varied angle stopper, it is characterized in that, described the first connector (11) comprises first component (111) and second component (112), described first component (111) is fixedly connected with the lower card of upper shutoff dish (1), the upper end of second component (112) is fixedly connected with first component (111), and the lower end of second component (112) is spherical, described the second connector (12) comprises cylindrical body (121), the lower end of cylindrical body (121) is fixedly connected with the upper disk surface of lower shutoff dish (2), the top inwall of cylindrical body (121) has annular projection (123), the spherical lower end of described second component (112) is limited in the top of cylindrical body (121) by this annular projection (123), locating part (122) is provided with in described cylindrical body (121), the upper end of locating part (122) has hemispherical groove, the spherical lower end of described second component (112) adopts rotatable mode to be located in described hemispherical groove.
5. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, described rotatable syndeton (2) comprises the first connector (11), second connector (12), described the first connector (11) is fixedly connected with the lower card of upper shutoff dish (1), second connector (12) is fixedly connected with the upper disk surface of lower shutoff dish (2), the lower end of the first connector (11) is located in the upper end of the second connector (12) by bearing pin (13), first connector (11) can rotate around described bearing pin (13).
6. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, described rotatable syndeton (2) comprises the first connector (11), second connector (12), described the first connector (11) is fixedly connected with the lower card of upper shutoff dish (1), second connector (12) is fixedly connected with the upper disk surface of lower shutoff dish (2), the lower end of the first connector (11) is connected with connecting filament (14), described connecting filament (14) is located in the upper end of the second connector (12) by bearing pin (13), first connector (11) can rotate around described bearing pin (13) via connecting filament (14).
7. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, described rotatable syndeton (2) comprises the first connector (11), the second connector (12), described the first connector (11) is fixedly connected with the lower card of upper shutoff dish (1), second connector (12) is fixedly connected with the upper disk surface of lower shutoff dish (2), the lower end of the first connector (11) is connected with connecting filament (14), and described connecting filament (14) connects the second connector (12).
8. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, described upper and lower two shutoff dishes (1) are all woven by nitinol alloy wire and form.
9. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, the shutoff dish (1) being positioned at upside adopts nitinol alloy wire to close up, and does not arrange steel bushing (3).
10. as claimed in claim 1 can self adaptation varied angle stopper, it is characterized in that, the shutoff dish (1) being positioned at downside is provided with the threaded steel bushing (4) that can be connected with screw thread push rod.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510578225.XA CN105054980B (en) | 2015-09-11 | 2015-09-11 | Self-adaptive variable angle plugging device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510578225.XA CN105054980B (en) | 2015-09-11 | 2015-09-11 | Self-adaptive variable angle plugging device |
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| Publication Number | Publication Date |
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| CN105054980A true CN105054980A (en) | 2015-11-18 |
| CN105054980B CN105054980B (en) | 2017-05-17 |
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| CN201510578225.XA Active CN105054980B (en) | 2015-09-11 | 2015-09-11 | Self-adaptive variable angle plugging device |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344100A (en) * | 2016-10-11 | 2017-01-25 | 北京工业大学 | Left auricle plugging device |
| CN107126240A (en) * | 2017-06-08 | 2017-09-05 | 有研医疗器械（北京）有限公司 | A kind of occluder for left auricle and its application method |
| WO2019075640A1 (en) * | 2017-10-17 | 2019-04-25 | 上海微创医疗器械（集团）有限公司 | Left atrial appendage occlusion device and left atrial appendage occlusion system |
| CN110974316A (en) * | 2019-11-19 | 2020-04-10 | 先健科技(深圳)有限公司 | Plugging device |
| CN111000601A (en) * | 2019-12-17 | 2020-04-14 | 先健科技(深圳)有限公司 | Occluder and occlusion system |
| CN111000598A (en) * | 2019-11-19 | 2020-04-14 | 先健科技(深圳)有限公司 | Plugging device |
| CN111000600A (en) * | 2019-12-17 | 2020-04-14 | 先健科技(深圳)有限公司 | Occluder and occlusion system |
| CN112022246A (en) * | 2020-11-06 | 2020-12-04 | 上海介入医疗器械有限公司 | Left auricle occluder and use method thereof |
| CN112932562A (en) * | 2021-02-01 | 2021-06-11 | 上海锦葵医疗器械股份有限公司 | Heart atrial septal defect occluder with flat two end surfaces and manufacturing method thereof |
| CN112932589A (en) * | 2021-02-01 | 2021-06-11 | 上海锦葵医疗器械股份有限公司 | Patent heart artery duct plugging device with two smooth end surfaces and manufacturing method thereof |
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| CN111000598A (en) * | 2019-11-19 | 2020-04-14 | 先健科技(深圳)有限公司 | Plugging device |
| CN110974316A (en) * | 2019-11-19 | 2020-04-10 | 先健科技(深圳)有限公司 | Plugging device |
| CN111000600A (en) * | 2019-12-17 | 2020-04-14 | 先健科技(深圳)有限公司 | Occluder and occlusion system |
| CN111000601A (en) * | 2019-12-17 | 2020-04-14 | 先健科技(深圳)有限公司 | Occluder and occlusion system |
| CN111000601B (en) * | 2019-12-17 | 2021-11-16 | 先健科技(深圳)有限公司 | Occluder and occlusion system |
| CN111000600B (en) * | 2019-12-17 | 2022-03-22 | 先健科技(深圳)有限公司 | Occluder and occlusion system |
| CN112022246A (en) * | 2020-11-06 | 2020-12-04 | 上海介入医疗器械有限公司 | Left auricle occluder and use method thereof |
| EP4241695A4 (en) * | 2020-11-06 | 2023-12-20 | Shanghai Push Medical Device Co., Ltd. | Occlusion device for left atrial appendage, and use method thereof |
| US11883033B2 (en) | 2020-11-06 | 2024-01-30 | Shanghai Push Medical Device Co., Ltd. | Left atrial appendage occluder, and method of application |
| CN112932562A (en) * | 2021-02-01 | 2021-06-11 | 上海锦葵医疗器械股份有限公司 | Heart atrial septal defect occluder with flat two end surfaces and manufacturing method thereof |
| CN112932589A (en) * | 2021-02-01 | 2021-06-11 | 上海锦葵医疗器械股份有限公司 | Patent heart artery duct plugging device with two smooth end surfaces and manufacturing method thereof |
| CN112932562B (en) * | 2021-02-01 | 2022-06-28 | 上海锦葵医疗器械股份有限公司 | Heart atrial septal defect occluder with flat two end surfaces and manufacturing method thereof |
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