CN104998810B - A kind of quick generation and the device and method for adjusting microvesicle distribution - Google Patents
A kind of quick generation and the device and method for adjusting microvesicle distribution Download PDFInfo
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- CN104998810B CN104998810B CN201510425472.6A CN201510425472A CN104998810B CN 104998810 B CN104998810 B CN 104998810B CN 201510425472 A CN201510425472 A CN 201510425472A CN 104998810 B CN104998810 B CN 104998810B
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Abstract
The present invention relates to a kind of quick generation and adjust microvesicle distribution device and method so that the control enhanced convenience of microvesicle.Using the memory effect of cavitation cloud, so as to control cavitation cloud to control microvesicle.And cavitation cloud can be produced by ultrasonic transducer, and realize the more preferable controllability of microvesicle, and simpler operation the features such as control cavitation cloud.Further, in order that the control of cavitation cloud is more controllable, the invention also provides the control method of regulation line.The characteristics of microvesicle being adsorbed by using regulation line, so as to set the shape of regulation line according to required shape and structure.And, using jet orifice, by producing the specific of microvesicle during water jet under ultrasonic wave, some region of microvesicle is evenly distributed.By above-mentioned apparatus and method, so as to reach the characteristics of microvesicle controls enhanced convenience, the controllability of microvesicle is more preferable.
Description
Technical field
The present invention relates to microbubble technique field, more particularly to a kind of quick generation and the device and the side that adjust microvesicle distribution
Method.
Background technology
With the progress of science and technology, microscopic manipulation is increasingly taken seriously and has many applications, such as microelectric technique,
Micro mechanical technology, biotechnology, micro-fluidic technologies, biochip technology, targeted therapy technology etc..These microscopic manipulations
It is the manipulation to solid, the manipulation to fluid mostly, in addition to manipulating microvesicle in the way of microchannel, there is presently no right well
The manipulation means of microvesicle, and bubble is controlled in the way of passage not only efficiency is low, long action time, and the microvesicle number of manipulation
Very low, control effect is undesirable.So as to be not easy to practical application.
The content of the invention
, control effect limited to microvesicle operating method in the prior art is undesirable, it is long to manipulate the time in order to solve by the present invention
The problems such as there is provided one kind not by any passage, the method that quickly and easily a large amount of microvesicles are manipulated.
To achieve the above object, the invention provides a kind of quick generation and adjust microvesicle distribution device.Including：Transducing
Device and reflecting surface；The transducer is used to send ultrasonic vibration, wherein, transducer also includes radiating surface.Radiating surface and reflecting surface
Between it is hydraulically full, liquid includes gas core.The radiating surface is used to radiate ultrasonic wave, the transducer work into the liquid
When making, the liquid between the radiating surface and the reflecting surface produces vacuole, is closed when the water turbomachinery to ideal form
Transducer, bubble collapse disappears, the microvesicle of bubble collapse and produced holding vacuole distribution shape.
More excellent, the transducer is respectively multiple with the reflecting surface, radiating surface and the reflecting surface phase of each transducer
To setting.
More excellent, the radiating surface is with the opposing parallel setting of reflecting surface, and the gap between radiating surface and reflecting surface is micron
Level is to grade.
More excellent, in addition to line is adjusted, the regulation line is arranged between radiating surface and reflecting surface.
More excellent, in addition to jet orifice, the jet orifice is horizontally disposed with, and jet orifice is penetrated by the edge of radiating surface and reflecting surface
To the liquid between radiating surface and reflecting surface.
On the other hand, present invention also offers a kind of quick generation and adjust microvesicle distribution method.
A kind of quick generation that the present invention is provided and the method for adjusting microvesicle distribution, comprise the following steps：
Reflecting surface will be set under ultrasonic transducer；
It is hydraulically full between the radiating surface and the reflecting surface of ultrasonic transducer；The liquid includes gas core；
Gas core produces vacuole under ultrasonic transducer effect；
Vacuole produces motion under ultrasonic transducer effect, up to water turbomachinery to ideal form；
Ultrasonic transducer is closed, bubble collapse disappears, and the microvesicle produced by bubble collapse is identical with the distributing position of vacuole.
More excellent, the ultrasonic transducer and radiating surface are respectively multiple, by the radiating surface and reflecting surface of ultrasonic transducer
It is oppositely arranged respectively.
More excellent, the radiating surface is opposing parallel to be arranged on reflecting surface, and the gap of radiating surface and reflecting surface is micro-
Meter level is to grade.
More excellent, in addition to regulation line, the position that line is arranged between radiating surface and reflecting surface will be adjusted.
More excellent, in addition to jet orifice, the jet orifice is set to horizontal by edge directive radiating surface and reflecting surface
Between liquid.
The apparatus and method that the present invention proposes a kind of quick generation and adjusts microvesicle distribution, so that the control of microvesicle is more
Plus convenience.Using the memory effect of cavitation cloud, and by controlling cavitation cloud to control microvesicle.Ultrasonic transducer can produce sky
Change cloud, and the more preferable controllability of microvesicle, and simpler operation are realized the features such as control cavitation cloud.Further, in order to
Make the control of cavitation cloud more controllable, the invention also provides the control method of regulation line, can be inhaled by using regulation line
The characteristics of attached microvesicle, so as to set the shape of regulation line according to required shape and structure.And, jet orifice is added, from
And by that the characteristics of generation microvesicle, some region of microvesicle can be made to be evenly distributed under ultrasonic wave during water jet.By above-mentioned
Method, reach microvesicle control enhanced convenience, the characteristics of controllability of microvesicle is more preferable.
Brief description of the drawings
Fig. 1 is the time interval figure of cavitation memory effect of the present invention；
Fig. 2 for the present invention in a kind of quick generation and adjust microvesicle distribution device structural representation；
Fig. 3 for the present invention in a kind of quick generation and adjust microvesicle distribution device add regulation line structural representation；
Fig. 4 is the quick lab diagram for producing and adjusting addition jet orifice after microvesicle distribution in the present invention.
Embodiment
Below by drawings and examples, technical scheme is described in further detail.
With the development of science and technology being required for using microvesicle in all trades and professions including medical treatment.In different demands,
Different requirements generally are distributed with to microvesicle.And in the prior art, also without the means manipulated well to microvesicle.This
Invention is directed to this technical problem, proposes a kind of quick generation and adjusts the device and method of microvesicle distribution.By using vacuole
Memory effect, enable the stop motion when stopping ultrasonic transducer of the vacuole of generation microvesicle.So as to open ultrasound in next time
The vacuole being equally distributed is produced during transducer.The function of microvesicle is produced under ultrasonic transducer effect using vacuole, is also utilized
The characteristics of vacuole can rest on this position when stopping ultrasonic transducer.Reach by controlling cavitation cloud to control microvesicle point
The problem of cloth.
In embodiments of the invention, include the memory effect of cavitation cloud.Fig. 1 is the time of cavitation memory effect of the present invention
Chart spacing.It should be noted that：Cavitation cloud is made up of infinite number of vacuole.A kind of cavitation cloud as shown in Figure 1, works as 300ms
When begin to shut off transducer, transducer is again started up during 1312ms, it can be seen that cavitation cloud returns to the original form substantially.By scheming
1 as can be seen that in 302ms and 1312ms, now transducer is had been switched off, and cavitation cloud is disappeared, and cavitation cloud is crumbled and fall produced
Microvesicle stays in cavitation cloud position, but because bubble size is too small and can not show.In 301ms and 1313ms, now
Just to close ultrasonic transducer, or the just moment of startup ultrasonic transducer, though the cavitation cloud for having part disappears, point of cavitation cloud
Cloth profile is substantially visible.As 300ms or 1314ms, now normal work or ultrasound is closed for ultrasonic transducer and has changed
Energy device, cavitation cloud distribution now is before being powered off and essentially identical before start again.
The place for originally having cavitation cloud is dispersed with microvesicle, and the place originally without cavitation cloud does not have microvesicle, so as to illustrate
Cavitation cloud has memory effect.At a time close ultrasonic transducer when, cavitation cloud crumble and fall generation gas core in a certain position
Stop.When being again turned on ultrasonic transducer, because the gas nuclear location that cavitation cloud is produced does not change, therefore phase can be produced
The cavitation cloud of similar shape.Because cavitation cloud can produce microvesicle under ul-trasonic irradiation, therefore it can also be formed and original same distribution
Microvesicle.
Fig. 2 for the present invention in a kind of quick generation and adjust microvesicle distribution device structural representation.As shown in Figure 2
A kind of quick generation and the device for adjusting microvesicle distribution, including radiating surface 1, reflecting surface 2 and liquid 3.Radiating surface 1 also includes ultrasound
Transducer, radiating surface 1 is connected with overtime transducer, so that the ultrasonic wave that ultrasonic transducer is sent is given off by radiating surface 1.
Shown radiating surface 1 is oppositely arranged with reflecting surface 2, has gap between radiating surface 1 and reflecting surface 2, and its gap is micron order or millimeter
Level.Hydraulically full 3 in gap between radiating surface and reflecting surface, gas core is also included in liquid 3.
When opening ultrasonic transducer, ultrasonic wave is delivered in liquid 3 by ultrasonic transducer by radiating surface 1, and is passed through
Reflecting surface 2 is returned.Due to there is gas core in liquid 3, so as to produce cavitation cloud under ul-trasonic irradiation, cavitation cloud is dissipated after crumbling and fall
Go out microvesicle.Gas core is random distribution in liquid 3, or stays in position when last time cavitation cloud is crumbled and fall, in the work of ultrasonic wave
Under, the position of cavitation cloud is moved change, and the distribution of gas core and the microvesicle produced by cavitation cloud will also change.So as to
Realize by controlling cavitation cloud, control the distribution of microvesicle.
Because cavitation cloud has memory effect, i.e., after ultrasonic transducer stops, gas core will also stop in a certain position.Again
The secondary distribution for opening microvesicle after cavitation cloud is almost identical with the distribution of microvesicle before closing.So that when needing the microvesicle that certain is distributed,
When the distribution of microvesicle is identical with required distribution, ultrasonic transducer is closed.When it is desired to be used, it is again turned on ultrasonic transducer just
Microvesicle distribution required for obtaining.
The above embodiment of the present invention provides a kind of easy device for obtaining required microvesicle distribution, but above-mentioned
In operating process, due to the erratic behavior of gas nuclear motion, it is impossible to it is absolutely accurate obtain required for microvesicle distributed architecture or
To the uncontrollability of process.
In another specific embodiment of the invention, a kind of quick generation for adding regulation line of proposition simultaneously adjusts microvesicle point
The device of cloth.
Fig. 3 for the present invention in a kind of quick generation and adjust microvesicle distribution device add regulation line structural representation.
A kind of device for including the quick generation of regulation line and adjusting microvesicle distribution as shown in Figure 3, including radiating surface 1, reflecting surface
2nd, liquid 3 and regulation line.Regulation line is arranged between reflecting surface 2 and radiating surface 1.It is hydraulically full between radiating surface 1 and reflecting surface 2
3, regulation line is in liquid 3.Radiating surface 1 radiates ultrasonic wave into liquid.The setting for adjusting line can be shape as depicted,
Can also be other arbitrary.The setting of regulation line is configured according to required microvesicle distribution, so as to produce preferable need
The microvesicle of shape is asked to be distributed.But its basic role is, regulation line can adsorb cavitation cloud, while can also limit the movement of gas core.
So as to obtain the microvesicle distributed architecture that some positions produced or do not produced microvesicle.
In addition to mentioning and microvesicle being adjusted by adjusting line described in above-described embodiment, in addition to one kind passes through control
The structure that water jet is controlled to microvesicle.
Fig. 4 is the quick lab diagram for producing and adjusting addition jet orifice after microvesicle distribution in the present invention.As shown in Figure 4 one
Plant the quick generation for including jet orifice and adjust the device of microvesicle distribution, including radiating surface 1, reflecting surface 2, liquid 3 and jet orifice
4。
Wherein jet orifice 4 level is arranged in the gap of radiating surface 1 and reflecting surface 2.Meanwhile, jet orifice 4 is not in radiation
On face 1 and the perspective plane of reflecting surface 2.Jet orifice 4 by radiating surface 1 and reflecting surface 2 edge directive radiating surface 1 and reflecting surface 2 it
Between liquid 3 so that the liquid gone out by jet, microvesicle is produced under ul-trasonic irradiation.Liquid jet by Entraining Effect,
Abundant gas core is carried in jet, these gas cores develop into cavitation cloud in the presence of ultrasound, so if wanting to generate large area
Uniform microvesicle, it is possible to use specific speed, the jet of specific spout, sprays specific fluid.It is covered with given zone in cavitation cloud
Behind domain, transducer is closed, the microvesicle after vacuole fragmentation will be left in original position, uniform microvesicle is formed in required region
Distribution.
Except the microvesicle distribution of the adjustment that is previously mentioned in above-mentioned three kinds of embodiments in certain plane, embodiments of the invention
It further comprises a kind of device for adjusting microvesicle distribution in big water body.
In this case, including multiple ultrasonic transducers and multiple reflectings surface 3, each ultrasonic transducer includes a spoke
Penetrate face 1.Radiating surface 1 and reflecting surface 2 are oppositely arranged, for example：In rectangular vessel, the bottom surface of container is set to reflecting surface 2,
The top surface of container is set to radiating surface 1；One side of container is set to radiating surface 1, face corresponding thereto is set to
Reflecting surface 2.So as to the work by controlling two ultrasonic transducers simultaneously, when microvesicle distribution reaches ideal form, close super
Sonic transducer.Above-described embodiment is a kind of concrete structure of the embodiment of the present invention, it is impossible to as limitation of the present invention.
In other configurations or big Water space, there is also certain memory effect for cavitation cloud.Added with multi-transducer or single transducer
The mode for adding a reflecting surface 2 controls sound field, and then controls cavitation cloud, recycles point of the memory effect control microvesicle of cavitation cloud
Cloth.Such case also should be in this patent protection domain.It is previously mentioned and is all existed using adjusting line, jet orifice etc. in the above-described embodiments
In the range of the concrete application of the present invention, and it is all within the scope of the present invention.
In addition, except the device for the adjustment microvesicle distribution being previously mentioned in above-mentioned all embodiments, can also in reflecting surface or
Specific depression or projection are laid on radiating surface, to be produced on specific position or not produce cavitation cloud.Can also
Design specific transducer or radiating surface, make radiating surface with specific modal vibration, produced in some specific regions or
Cavitation cloud is not produced.Above-mentioned all embodiments are the concrete application of the present invention, as long as by controlling cavitation cloud to control
The device and structure of microvesicle distribution are all in the protection domain of this patent.
On the other hand, a kind of method that specific embodiment of the invention further comprises quick generation and adjust microvesicle distribution,
Its step is as follows：
Reflecting surface will be set under ultrasonic transducer；
Ultrasonic transducer also includes radiating surface, and radiating surface is used to connect ultrasonic transducer, so that ultrasonic transducer be sent
Ultrasonic wave given off by radiating surface.Radiating surface is oppositely arranged with reflecting surface, has gap between radiating surface and reflecting surface, therebetween
Gap is micron order or grade.
It is hydraulically full between the radiating surface and the reflecting surface of ultrasonic transducer；The liquid includes gas core；
It is hydraulically full in gap between radiating surface and reflecting surface, gas core is also included in liquid.When opening ultrasonic transducer
When, ultrasonic wave is delivered in liquid by ultrasonic transducer by radiating surface, and is returned by reflecting surface.
Open ultrasonic transducer；Wherein, gas core is produced under ultrasonic transducer effect becomes vacuole；
Due to there is gas core in liquid, so as to produce cavitation cloud under ul-trasonic irradiation, cavitation cloud dissipates out micro- after crumbling and fall
Bubble.
The distribution shape of cavitation cloud is observed, until cavitation cloud moves to ideal form；
Due to the effect of transducer, cavitation cloud forms certain spatial distribution, then point of the microvesicle produced by cavitation cloud
Cloth will also change.It is achieved thereby that by controlling cavitation cloud, controlling the distribution of microvesicle.
Close ultrasonic transducer；
Because cavitation cloud has memory effect, i.e., after ultrasonic transducer is stopped, vacuole disappears, the gas that bubble collapse is produced
Core will stop in a certain position.The distribution of microvesicle is almost identical before being again turned on the distribution of the rear microvesicle of cavitation cloud and closing.From
And when needing the microvesicle that certain is distributed, when the distribution of microvesicle is identical with required distribution, close ultrasonic transducer.When needing to use
When, it is the microvesicle distribution required for regard to that can obtain to be again turned on ultrasonic transducer.
The above embodiment of the present invention provides a kind of easy method for obtaining required microvesicle distribution, but above-mentioned
In operating process, due to the erratic behavior of gas nuclear motion, it is impossible to it is absolutely accurate obtain required for microvesicle distributed architecture or
To the uncontrollability of process.
The specific embodiment of the present invention yet another method is provided that a kind of quick generation for adding regulation line simultaneously adjusts micro-
Steep the device of distribution, including radiating surface, reflecting surface, liquid and regulation line.Regulation line is arranged between reflecting surface and radiating surface.Spoke
Penetrate hydraulically full between face and reflecting surface, regulation line is in a liquid.Radiate and radiate ultrasonic wave towards in liquid.Adjust the setting of line
Can be shape as depicted or other arbitrary.Regulation line setting be according to required microvesicle be distributed into
Row is set, so as to produce the microvesicle distribution of desirability shape.But its basic role is, regulation line can adsorb cavitation cloud, enter
And limit the movement of microvesicle.So as to obtain the microvesicle distributed architecture that some positions produced or do not produced microvesicle.
In addition to mentioning and microvesicle being adjusted by adjusting line described in the method for above-described embodiment, in addition to it is a kind of logical
Cross the method that control water jet is controlled to microvesicle, including radiating surface, reflecting surface, liquid and jet orifice.
Wherein jet orifice level is arranged between radiating surface and the gap of reflecting surface, meanwhile, jet orifice is not in radiating surface
On the perspective plane of reflecting surface.Liquid of the jet orifice between radiating surface and the edge directive radiating surface and reflecting surface of reflecting surface,
So as to the liquid gone out by jet, and with producing microvesicle under ul-trasonic irradiation.Liquid jet is by Entraining Effect, in jet
Middle to carry abundant gas core, these gas cores develop into cavitation cloud in the presence of ultrasound, so if thinking that generation large area is uniform
Microvesicle, it is possible to use specific speed, the jet of specific spout, spray specific fluid.After cavitation cloud is covered with specific region,
Transducer is closed, the microvesicle after vacuole fragmentation will be left in original position, uniform microvesicle distribution is formed in required region.
Except what is be previously mentioned in the method for above-mentioned all embodiments, it can also be laid on reflecting surface or radiating surface specific
Depression or projection, to be produced on specific position or not produce cavitation cloud.Can also design specific transducer or
Person's radiating surface, makes radiating surface with specific modal vibration, cavitation cloud is produced or do not produce in some specific regions.Above-mentioned institute
Some embodiments are the concrete application of the present invention, as long as the device and structure of microvesicle distribution are controlled by controlling cavitation cloud
All in the protection domain of this patent.
Above-described embodiment, has been carried out further to the purpose of the present invention, technical scheme and beneficial effect
Describe in detail, should be understood that the embodiment that the foregoing is only the present invention, be not intended to limit the present invention
Protection domain, within the spirit and principles of the invention, any modification, equivalent substitution and improvements done etc. all should be included
Within protection scope of the present invention.
Claims (4)
1. a kind of quick generation and the device for adjusting microvesicle distribution, it is characterised in that including：Transducer and reflecting surface；
The transducer is used to send ultrasonic vibration；Wherein, transducer also includes radiating surface；
Hydraulically full between radiating surface and reflecting surface, liquid includes gas core；
The radiating surface is used to radiate ultrasonic wave into the liquid；
During the transducer work, the liquid between the radiating surface and the reflecting surface produces vacuole, when the water turbomachinery
The microvesicle of transducer, bubble collapse and produced holding vacuole distribution shape is closed during to ideal form；
The transducer is respectively multiple with the reflecting surface, and radiating surface and the reflecting surface of each transducer are oppositely arranged；
The radiating surface is with the opposing parallel setting of reflecting surface, and the gap between radiating surface and reflecting surface is micron order to grade；
Also include regulation line, the regulation line is arranged between radiating surface and reflecting surface.
2. a kind of quick generation according to claim 1 and the device for adjusting microvesicle distribution, it is characterised in that：Also include penetrating
Head piece, the jet orifice is horizontally disposed with, and the liquid in jet orifice is by radiating surface and the edge directive radiating surface of reflecting surface and reflection
Between face.
3. a kind of quick generation and the method for adjusting microvesicle distribution, comprise the following steps：
Reflecting surface will be set under ultrasonic transducer；
It is hydraulically full between the radiating surface and the reflecting surface of ultrasonic transducer；The liquid includes gas core；
Gas core produces vacuole under ultrasonic transducer effect；
Vacuole produces motion under ultrasonic transducer effect, up to water turbomachinery to ideal form；
Ultrasonic transducer is closed, bubble collapse disappears, and the microvesicle produced by bubble collapse is identical with the distributing position of vacuole；
Wherein, the ultrasonic transducer and radiating surface are respectively multiple, and the radiating surface of ultrasonic transducer and reflecting surface are distinguished into phase
To setting；
The radiating surface is opposing parallel to be arranged on reflecting surface, and the gap of radiating surface and reflecting surface is micron order to millimeter
Level；
Also include regulation line, the position that line is arranged between radiating surface and reflecting surface will be adjusted.
4. a kind of quick generation according to claim 3 and the method for adjusting microvesicle distribution, it is characterised in that：Also include penetrating
Head piece, the jet orifice is set to horizontal, and the liquid in jet orifice is between edge directive radiating surface and reflecting surface.
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| CN101734345A (en) * | 2009-12-22 | 2010-06-16 | 上海大学 | Method for restraining cavitation generation and flow separation in blade of liquid machine |
| SG189567A1 (en) * | 2011-10-14 | 2013-05-31 | Singapore Polytechnic | System and method for providing mixed mode energies during a continuous chemical flow process |
| CN104128328A (en) * | 2014-07-24 | 2014-11-05 | 中国科学院声学研究所 | Jetting and nucleus supplementing ultrasonic cavitation device and method |
| CN104138736B (en) * | 2014-08-19 | 2016-08-31 | 中国科学院声学研究所 | A kind of ultrasonic cavitation device |
| CN205199871U (en) * | 2015-07-17 | 2016-05-04 | 中国科学院声学研究所 | Device that microbubble distributes is produced and adjusted fast |
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