CN104998308A - Leucocyte depletion filter and filtering method - Google Patents
Leucocyte depletion filter and filtering method Download PDFInfo
- Publication number
- CN104998308A CN104998308A CN201510466173.7A CN201510466173A CN104998308A CN 104998308 A CN104998308 A CN 104998308A CN 201510466173 A CN201510466173 A CN 201510466173A CN 104998308 A CN104998308 A CN 104998308A
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- filter
- upper cover
- lower cover
- fluid passage
- filter membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
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- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention provides a leucocyte depletion filter and a filtering method. The leucocyte depletion filter comprises an upper cover, a lower cover, and a filter membrane. The upper cover and the lower cover are fixedly connected. The filter membrane is packaged between the upper cover and the lower cover. An upper cover fluid flow passage is arranged on the upper cover. A lower cover fluid flow passage is arranged on the lower cover. The outlet of the upper cover fluid flow passage and the inlet of the lower cover fluid flow passage are respectively on two sides of the filter membrane. The inlet of the lower cover fluid flow passage is higher than the outlet of the upper cover fluid flow passage. In filtering operation, the inlet of the upper cover fluid flow passage is the inlet of the filter, and inlet of the filter is connected and communicated with a pre-filter bag in a sealed manner. The outlet of the lower cover fluid flow passage is the outlet of the filter. The outlet of the filter is connected and communicated with a post-filter bag in a sealed manner. The inlet of the filter is higher than the outlet of the filter. The leucocyte depletion filter can accelerate filtering velocity of blood, shorten depletion time of leucocytes, and leucocyte depletion effect is good.
Description
Technical field
The present invention relates to leukoreduction filter technical field, especially relate to a kind of leukocyte depletion filter and filter method.
Background technology
At present, the application of leukocyte depletion filter is extensively popularized, and it ensure that transfusion safety for blood used in clinic, avoids transfusion reaction.As everyone knows, leukocyte depletion filter leukocyte depletion removes leukocytic by the deadweight of blood and erythrocytic deformation characteristic principle, and the vertical drop design before filter after blood and filter between blood is greater than 1 meter.
Existing leukocyte depletion filter comprises duricrust filter and soft shell filter, and the import of blood is arranged on the top of filter, and the outlet of blood is arranged on the bottom of filter.In use, leukocyte depletion filter with sack before filter, filter back pkt. sub-connection and become a sealing system, there is a large amount of gas in its internal system, according to test, gas content is not less than 50ml.In the process of leukocyte depletion, blood before filter is hung vertically on the hook on the white facility of filter, before filter, blood enters leukocyte depletion filter along connecting line from the import at leukocyte depletion filter top from the front sack of filter, flow out from the outlet bottom leukocyte depletion filter, then after entering filter, sack is preserved, and completes leukocytic filtration.This leukocyte depletion filter in actual use, often occurs that the rate of filtration is slow, the problems such as even generation filtration clogging, and leukocyte depletion rate is defective.
Summary of the invention
The technical problem to be solved in the present invention is: for prior art Problems existing, provides a kind of leukocyte depletion filter and filter method, improves leukoreduction filter speed and leukocyte depletion rate.
The technical problem to be solved in the present invention realizes by the following technical solutions: a kind of leukocyte depletion filter, comprise upper cover, lower cover and filter membrane, described upper cover is fixedly connected with between lower cover, described filter membrane is encapsulated between upper cover and lower cover, upper covering, upper cover fluid passage is set, under cover lower cover fluid passage be set, described upper cover outlet flow channels, lower cover fluid channel inlet lay respectively at filter membrane both sides, and lower cover fluid channel inlet is higher than upper cover outlet flow channels.
Preferably, cover and arrange upper cover deep gouge on described, cover and arrange lower cover deep gouge under described, described filter membrane is encapsulated in the cavity that jointly formed by upper cover deep gouge and lower cover deep gouge.
Preferably, cover on described and lobe is set as the outer link of upper cover, the outer link of the through upper cover in described upper cover fluid passage.
Preferably, described upper cover is outer is that integrated molding is connected between link with upper cover.
Preferably, cover under described and lobe is set as the outer link of lower cover, the outer link of the through lower cover in described lower cover fluid passage.
Preferably, described lower cover is outer is that integrated molding is connected between link with lower cover.
Preferably, described filter membrane is divided into filter membrane coarse filtration layer, filter membrane filter bed of essence and ultrafiltration through membranes layer, described filter membrane coarse filtration layer is near upper cover outlet flow channels end, described ultrafiltration through membranes layer is near lower cover fluid channel inlet end, described filter membrane filter bed of essence is between filter membrane coarse filtration layer and ultrafiltration through membranes layer, and the filtering micropore aperture on filter membrane coarse filtration layer is greater than the filtering micropore aperture on filter membrane filter bed of essence, the filtering micropore aperture on described filter membrane filter bed of essence is greater than the filtering micropore aperture on ultrafiltration through membranes layer.
A kind of leukoreduction filter method, leukocyte depletion filter as above is adopted to carry out, upper cover fluid channel inlet on described leukocyte depletion filter is filter import, described lower cover outlet flow channels is filter outlets, described filter import is higher than filter outlets, and described filter import communicates with being tightly connected between sack before filter, be tightly connected between sack after filter outlets and filter and communicate.
Compared with prior art, the invention has the beneficial effects as follows: due to upper cover outlet flow channels, lower cover fluid channel inlet lays respectively at filter membrane both sides, and lower cover fluid channel inlet is higher than upper cover outlet flow channels, blood to be filtered flows out from upper cover outlet flow channels, after filter membrane filtrating leukocytes, enter lower cover fluid passage from lower cover fluid channel inlet, thus achieve the leukoreduction filter mode of blood low in and high out, this leukoreduction filter mode can get rid of the gas of filter inside cavity first effectively, make blood in filter process not by the impact of the gas pressure in filter cavity, the resistance that blood flow is subject to is less, ensure that blood filtration is unobstructed, therefore, the rate of filtration of blood is fast, the leukocyte depletion time is short, meanwhile, because blood is from bottom to top all by filter membrane, effective filter table area entirety of filter membrane is all fully utilized, and therefore, leukocytic filtration result is good, can be up to state standards completely.
Accompanying drawing explanation
Fig. 1 is the overall structure figure of a kind of leukocyte depletion filter of the present invention.
Fig. 2 is the front view (sectional view) of the upper cover in Fig. 1.
Fig. 3 is the top view of the upper cover in Fig. 1.
Fig. 4 is the bedded structure figure of the filter membrane in Fig. 1.
Fig. 5 is the front view (sectional view) of the lower cover in Fig. 1.
Fig. 6 is the top view of the lower cover in Fig. 1.
Fig. 7 is the filter method schematic diagram of a kind of leukocyte depletion filter of the present invention.
Labelling in figure: 1-upper cover, 2-filter membrane, 3-lower cover, sack before 4-filter, 5-filters dummy pipe, and 6-filters rear tube, sack after 7-filter, the import of 11-filter, the outer link of 12-upper cover, 13-upper cover fluid passage, 14-upper cover deep gouge, 21-filter membrane coarse filtration layer, 22-filter membrane filter bed of essence, 23-ultrafiltration through membranes layer, 31-filter outlets, the outer link of 32-lower cover, 33-lower cover deep gouge, 34-lower cover fluid passage.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with the drawings and specific embodiments, the present invention is described in detail.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
A kind of leukocyte depletion filter as shown in Figure 1, comprises upper cover 1, lower cover 3 and filter membrane 2, and described filter membrane 2 is encapsulated between upper cover 1 and lower cover 3.Upper cover 1 is wherein round, and adopt the molding of PC material injection, its concrete structure as shown in Figure 2 and Figure 3, upper cover 1 is fixedly connected with lobe as the outer link 12 of upper cover by integrated molding connected mode, simultaneously, upper cover 1 arranges independently L shape upper cover fluid passage 13, and the outer link 12 of the through upper cover in described upper cover fluid passage 13 and upper cover 1 lid, upper cover fluid passage 13 import is filter import 11.Described lower cover 3 is also round, and adopt the molding of PC material injection, its concrete structure as shown in Figure 5, Figure 6, lower cover 3 is fixedly connected with lobe as the outer link 32 of lower cover by integrated molding connected mode, simultaneously, lower cover 3 arranges independently L shape lower cover fluid passage 34, and the outer link 32 of the through lower cover in described lower cover fluid passage 34 and lower cover 3 lid, lower cover fluid passage 34 exports as filter outlets 31.The socket between leukocyte depletion filter and external pipeline can be facilitated to operate by the outer link 12 of upper cover, the outer link 32 of lower cover, and the outer link 12 of upper cover, the outer link 32 of lower cover are preferably designed to pyramidal structure, to ensure the reliability be socketed.Described upper cover fluid passage 13 exports, lower cover fluid passage 34 import lays respectively at filter membrane 2 both sides, and the import of lower cover fluid passage 34 is higher than the outlet of upper cover fluid passage 13.
When above-mentioned leukocyte depletion filter assembling, first filter membrane 2 can be put into lower cover 3; Then, upper cover 1 and lower cover 3 are closed, and make filter import 11, relative both sides that filter outlets 31 lays respectively at leukocyte depletion filter; Finally, by ultrasonic welding machine, upper cover 1 is welded to be fused into one with lower cover 3, make upper cover 1 and lower cover 3 compacting filter membrane 2 simultaneously, after being fixedly connected with between upper cover 1 with lower cover 3, namely complete leukocyte depletion filter finished product is formed, upper cover fluid passage 13 wherein extends to bottom filter membrane 2 from filter import 11, and lower cover fluid passage 34 extends to filter membrane 2 top from filter outlets 31, as shown in Figure 1.
As shown in Fig. 2, Fig. 5, upper cover deep gouge 14 can be set on upper cover 1, correspondingly, lower cover 3 arranges lower cover deep gouge 33, described filter membrane 2 is encapsulated in by the common cavity formed of upper cover deep gouge 14 and lower cover deep gouge 33, adopt such structure that the structure of leukocyte depletion filter can be made compacter, and be conducive to improving upper cover 1, sealing property between lower cover 3 and filter membrane 2, guarantee that the filtration of blood more fully, thoroughly.
Filter membrane 2 in above-mentioned leukocyte depletion filter is formed by overlapped way consolidation by polyester non-woven fabrics and/or glass fibre.In order to strengthen it to leukocytic filtration result, described filter membrane 2 preferably has the filter membrane of multiple structure.Filter membrane 2 as shown in Figure 4, be divided into filter membrane coarse filtration layer 21, filter membrane filter bed of essence 22 and ultrafiltration through membranes layer 23, described filter membrane coarse filtration layer 21, filter membrane filter bed of essence 22 can be identical with the material of ultrafiltration through membranes layer 23, also can be different, and, filtering micropore aperture on filter membrane coarse filtration layer 21 is greater than the filtering micropore aperture on filter membrane filter bed of essence 22, and the filtering micropore aperture on filter membrane filter bed of essence 22 is greater than the filtering micropore aperture on ultrafiltration through membranes layer 23.Described filter membrane coarse filtration layer 21 is near upper cover fluid passage 13 port of export, and described ultrafiltration through membranes layer 23 is near lower cover fluid passage 34 entrance point, and described filter membrane filter bed of essence 22 is between filter membrane coarse filtration layer 21 and ultrafiltration through membranes layer 23.Wherein, on described filter membrane coarse filtration layer 21, the aperture of equally distributed filtering micropore is 30-40 micron, preferably 35 microns; On described filter membrane filter bed of essence 22, the aperture of equally distributed filtering micropore is 20-28 micron, preferably 25 microns; On described ultrafiltration through membranes layer 23, the aperture of equally distributed filtering micropore is 15-20 micron, preferably 18 microns.
When utilizing above-mentioned leukocyte depletion filter to carry out leukoreduction filter, the structure of its filtration system as shown in Figure 7, the outer link 12 of upper cover on described leukocyte depletion filter communicates by being tightly connected between filter dummy pipe 5 with sack 4 before filter, the outer link 32 of lower cover communicates by being tightly connected between filter rear tube 6 with sack 7 after filter, thus defines the closed system of filtration channel.Upper cover fluid passage 13 import is filter import 11, and lower cover fluid passage 34 exports as filter outlets 31, and described filter import 11 is higher than filter outlets 31.When filtering beginning, before filter, in sack 4, blood to be filtered flows through filter dummy pipe 5 and enters upper cover fluid passage 13 from filter import 11, and arrive bottom filter membrane 2 along upper cover fluid passage 13, successively after the filtration of filter membrane coarse filtration layer 21, filter membrane filter bed of essence 22 and ultrafiltration through membranes layer 23, lower cover fluid passage 34 is flowed out into from filter membrane 2 top, then flow out from filter outlets 31, then enter after flowing through filter rear tube 6 in the rear sack 7 of filter, complete filter process.
Especially, it should be noted that, leukocyte depletion filter of the present invention overcomes existing leukocyte depletion filter technology prejudice in design.Analyze according to statistics, the structural design of existing leukocyte depletion filter is all the top import of blood to be filtered being arranged on filter inner chamber, and the outlet of blood after filtering is arranged on the bottom of filter inner chamber, therefore, blood flows through leukocyte depletion filter in the mode of high in and low out.And in filter operation process, due to sack before leukocyte depletion filter and filter, filter back pkt. sub-connection and become a sealing system, there is a large amount of gas in its internal system, according to test, this gas content is not less than 50ml.Therefore, in the process of leukocyte depletion, blood to be filtered is from the front sack of filter along pipeline and enters leukocyte depletion filter inner chamber from leukocyte depletion filter top inlet, makes intrasystem gas can first enter leukocyte depletion filter inside cavity, comprises the gas of leukocyte depletion filter therein.Because leukocyte depletion filter is vertical hanging, gas can be in the upper strata of leukocyte depletion filter inside cavity always.When the top of blood from leukocyte depletion filter cavity enters, then flow out from leukocyte depletion filter cavity bottom, blood is just made to be that from top to down passes through filter membrane, this cannot exclude causing the gas being in leukocyte depletion filter inside cavity upper strata from leukocyte depletion filter inside, thus define an atmospheric pressure, pressure after the existence of this atmospheric pressure directly causes blood to enter leukocyte depletion filter increases, and makes the flows decrease of blood; In addition, because leukocyte depletion filter inside exists this atmospheric pressure, be subject to certain resistance after causing blood to enter filter, thus blood can not pass through upper strata membrane filtration leukocyte effectively, leukocytic filtration effective area is reduced greatly, have impact on leukocytic actual clearance.Therefore, existing leukocyte depletion filter in actual use, often occurs that the rate of filtration is slow, the problems such as even generation filtration clogging, and leukocytic rejection rate is defective.
But, leukocyte depletion filter of the present invention is in filter process, because lower cover fluid passage 34 import exports higher than upper cover fluid passage 13, when blood to be filtered from filter before sack 4 outflow after, the blood of flowing is first by the cavity in the middle part of intrasystem gas press-in leukocyte depletion filter, gas is in the position, upper strata that filter enters blood face after entering filter cavity, along with blood constantly enters in filter cavity bottom upper cover fluid passage 13, gas is after the pressure effect increased continuously being subject to blood, by after filter membrane 2 along lower cover fluid passage 34 discharge strainer, and after the filter that filter rear tube 6 enters below filter in sack 7.After air scavenge all in filter inner chamber is complete, blood is just flowed out from filter top exit and lower cover fluid passage 34 import by filter membrane 2, and enters lower cover fluid passage 34.In whole filter process, due in leukocyte depletion filter cavity without gas, the resistance that blood flow is subject to is less, and therefore, blood filtration is unobstructed, and the speed of filtration is also fast, shortens the leukocytic filtering time; And because blood is low in and high out ground flow filter, make blood can from bottom to up all by filter membrane 2, make effective filter table area entirety of filter membrane 2 all be fully utilized, therefore, leukocytic filtration result be good, can be up to state standards completely.In addition, because the upper cover fluid passage 13 on upper cover 1, the lower cover fluid passage 34 on lower cover 3 are independently L shape fluid passage, it can play certain cushioning effect to the blood of flowing, is conducive to improving leukocytic filtration result.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, it should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. a leukocyte depletion filter, it is characterized in that: comprise upper cover (1), lower cover (3) and filter membrane (2), be fixedly connected with between described upper cover (1) with lower cover (3), described filter membrane (2) is encapsulated between upper cover (1) and lower cover (3), upper cover (1) arranges upper cover fluid passage (13), lower cover (3) arranges lower cover fluid passage (34), described upper cover fluid passage (13) outlet, lower cover fluid passage (34) import lays respectively at filter membrane (2) both sides, and lower cover fluid passage (34) import exports higher than upper cover fluid passage (13).
2. a kind of leukocyte depletion filter according to claim 1, it is characterized in that: described upper cover (1) is arranged upper cover deep gouge (14), described lower cover (3) is arranged lower cover deep gouge (33), described filter membrane (2) is encapsulated in by the common cavity formed of upper cover deep gouge (14) and lower cover deep gouge (33).
3. a kind of leukocyte depletion filter according to claims 1 or 2, it is characterized in that: described upper cover (1) is arranged lobe as the outer link (12) of upper cover, the outer link (12) of the through upper cover of described upper cover fluid passage (13).
4. a kind of leukocyte depletion filter according to claim 3, is characterized in that: described upper cover is outer is that integrated molding is connected between link (12) with upper cover (1).
5. a kind of leukocyte depletion filter according to claims 1 or 2, it is characterized in that: described lower cover (3) is arranged lobe as the outer link (32) of lower cover, the outer link (32) of the through lower cover of described lower cover fluid passage (34).
6. a kind of leukocyte depletion filter according to claim 5, is characterized in that: described lower cover is outer is that integrated molding is connected between link (32) with lower cover (3).
7. a kind of leukocyte depletion filter according to claims 1 or 2, it is characterized in that: described filter membrane (2) is divided into filter membrane coarse filtration layer (21), filter membrane filter bed of essence (22) and ultrafiltration through membranes layer (23), described filter membrane coarse filtration layer (21) is near upper cover fluid passage (13) port of export, described ultrafiltration through membranes layer (23) is near lower cover fluid passage (34) entrance point, described filter membrane filter bed of essence (22) is positioned between filter membrane coarse filtration layer (21) and ultrafiltration through membranes layer (23), and the filtering micropore aperture on filter membrane coarse filtration layer (21) is greater than the filtering micropore aperture on filter membrane filter bed of essence (22), filtering micropore aperture on described filter membrane filter bed of essence (22) is greater than the filtering micropore aperture on ultrafiltration through membranes layer (23).
8. a leukoreduction filter method, it is characterized in that: adopt the leukocyte depletion filter as described in claim 1-7 to carry out, upper cover fluid passage (13) import on described leukocyte depletion filter is filter import (11), described lower cover fluid passage (34) outlet is filter outlets (31), described filter import (11) is higher than filter outlets (31), and described filter import (11) communicates with being tightly connected between sack (4) before filter, filter outlets (31) and filter are tightly connected between sack (7) afterwards and communicate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510466173.7A CN104998308A (en) | 2015-07-31 | 2015-07-31 | Leucocyte depletion filter and filtering method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510466173.7A CN104998308A (en) | 2015-07-31 | 2015-07-31 | Leucocyte depletion filter and filtering method |
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| CN104998308A true CN104998308A (en) | 2015-10-28 |
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| CN201510466173.7A Pending CN104998308A (en) | 2015-07-31 | 2015-07-31 | Leucocyte depletion filter and filtering method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212931A (en) * | 2021-04-15 | 2022-10-21 | 武汉介观生物科技有限责任公司 | Platelet in-vitro release system and platelet production method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110313A (en) * | 1994-04-15 | 1995-10-18 | 南京红十字血液中心 | Glass fibre leucocyte filter |
| CN201058159Y (en) * | 2007-06-27 | 2008-05-14 | 上海达华医疗器械有限公司 | Filter for removing white blood cell |
| CN203060401U (en) * | 2012-09-14 | 2013-07-17 | 南京双威生物医学科技有限公司 | Soft shell white blood cell filter |
| CN204910252U (en) * | 2015-07-31 | 2015-12-30 | 四川南格尔生物科技有限公司 | Leucocyte filter |
-
2015
- 2015-07-31 CN CN201510466173.7A patent/CN104998308A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110313A (en) * | 1994-04-15 | 1995-10-18 | 南京红十字血液中心 | Glass fibre leucocyte filter |
| CN201058159Y (en) * | 2007-06-27 | 2008-05-14 | 上海达华医疗器械有限公司 | Filter for removing white blood cell |
| CN203060401U (en) * | 2012-09-14 | 2013-07-17 | 南京双威生物医学科技有限公司 | Soft shell white blood cell filter |
| CN204910252U (en) * | 2015-07-31 | 2015-12-30 | 四川南格尔生物科技有限公司 | Leucocyte filter |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212931A (en) * | 2021-04-15 | 2022-10-21 | 武汉介观生物科技有限责任公司 | Platelet in-vitro release system and platelet production method |
| CN115212931B (en) * | 2021-04-15 | 2024-06-11 | 武汉介观生物科技有限责任公司 | Platelet in-vitro release system and platelet production method |
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Application publication date: 20151028 |