CN104997742A - Ginkgo ketonic ester dripping pill and preparation method thereof - Google Patents
Ginkgo ketonic ester dripping pill and preparation method thereof Download PDFInfo
- Publication number
- CN104997742A CN104997742A CN201510378999.8A CN201510378999A CN104997742A CN 104997742 A CN104997742 A CN 104997742A CN 201510378999 A CN201510378999 A CN 201510378999A CN 104997742 A CN104997742 A CN 104997742A
- Authority
- CN
- China
- Prior art keywords
- lactone
- polyethylene glycol
- ginkgo flavone
- medicinal substrate
- ginkgo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a ginkgo ketonic ester dripping pill, which comprises ginkgo ketonic ester and medicinal matrix, and the weight percentage of the two components is 10%-18%:82%-90%. The medicinal matrix comprises polyethylene glycol 4000, polyethylene glycol 6000 and polyethylene glycol 8000, and the weight ratio is 3-5:1-1.3:0.4-0.7. The invention also discloses a preparation method of the dripping pill. The product provided by the invention is composed of ginkgo ketonic ester and medicinal matrix according to a specific proportion, and the medicinal matrix is mixed from three kinds of polyethylene glycol, whose molecular weights are different, thereby ensuring fast disintegration speed of the ginkgo ketonic ester dripping pill, and the disintegration time is 6-10 minutes. The Ginkgo ketonic ester dripping pill can have a quick effect on human bodyand illness of a patient can be relieved.
Description
Technical field
The present invention relates to a kind of dropping pill formulation and preparation method thereof, especially bilobanone ester dropping pills and preparation method thereof.
Background technology
Drop pill instills in not miscible condensed fluid after referring to that solid or liquid medicine and substrate heat and dissolve mixing, shrinks condensation and the preparation made; Substrate generally comprises water-soluble base and water-insoluble base, and conventional has polyethylene glycol 6000, gelatin and stearic acid etc.; Condensed fluid must be safe and harmless, and conventional has liquid Paraffin, vegetable oil, methyl-silicone oil and water etc.
Cardiovascular and cerebrovascular disease has the features such as high incidence, high mortality and high disability rate, is the number one killer of human health.The drug main of current this disease for the treatment of will take ginkgo flavone and lactone as Main Ingredients and Appearance, has and uses drop pill as treatment cardiovascular and cerebrovascular disease; But existing bilobanone ester dropping pills disintegration time in gastrointestinal is long, be generally 15 ~ 18 minutes, for the misery that urgent need solution disease causes, allow patient stand and seem that this time is comparatively long.
Patent application CN200610113450.7 and CN201010112227.7 proposed before applicant reports bilobanone ester dropping pills preparation, but the drop pill obtained by it can not be satisfactory in dissolution, disintegration, outward appearance, the painful problem of patient cannot be solved all the time.Therefore, the particularly ginkgo flavone and lactone field in dropping pill formulation field, has needs that are urgent and that continue to the drop pill product of the character such as dissolution, disintegration, outward appearance with improvement.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, propose a kind of new bilobanone ester dropping pills preparation, its disintegration time is short, thus effectively alleviates patient's burden.
In order to realize foregoing invention object, one aspect of the present invention provides following bilobanone ester dropping pills: it comprises ginkgo flavone and lactone and medicinal substrate, and both percentage by weights are 10% ~ 18%:82% ~ 90%; Described medicinal substrate is made up of by weight 3 ~ 5:1 ~ 1.3:0.4 ~ 0.7 Macrogol 4000, polyethylene glycol 6000 and PEG 8000.
The present invention provides the method preparing bilobanone ester dropping pills on the other hand, and the method comprises the steps:
(1), by the weight ratio of 10% ~ 18%:82% ~ 90% get ginkgo flavone and lactone and medicinal substrate, described medicinal substrate is made up of by weight 3 ~ 5:1 ~ 1.3:0.4 ~ 0.7 Macrogol 4000, polyethylene glycol 6000 and polyethylene glycol-800;
(2), ginkgo flavone and lactone is crossed 100 ~ 150 mesh sieves;
(3), by Macrogol 4000, polyethylene glycol 6000 and PEG 8000 mix, be heated to 70 ~ 85 DEG C, stir, be incubated 2 ~ 3 minutes; Add step (2) sieve after ginkgo flavone and lactone, stir evenly;
(4), step (3) mixture instillation condensed fluid in become drop pill.
Preferably, the percentage by weight of described ginkgo flavone and lactone and medicinal substrate is 13% ~ 15%:85% ~ 87%.
Preferably, the percentage by weight of described ginkgo flavone and lactone and medicinal substrate is 14%:86%.
Preferably, in described medicinal substrate, the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4 ~ 5:1.2 ~ 1.3:0.6 ~ 0.7.
Preferably, in described medicinal substrate, the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4.5:1.2:0.6.
Preferably, step (3) in ginkgo flavone and lactone to add speed be 12 ~ 15 gram/minute.
Preferably, step (3) stir evenly after mixture continue 60 ~ 65 DEG C of insulations.
Preferably, described condensed fluid is one or more in liquid paraffin, methyl-silicone oil, dimethicone or vegetable oil.
Preferably, ginkgo flavone and lactone crosses 120 ~ 130 mesh sieves.
Compared with prior art, the present invention has the following advantages.Medicinal substrate in bilobanone ester dropping pills is mixed in specific proportions by the Polyethylene Glycol of three kinds of different molecular weights.Applicant is surprised to find that and uses such medicinal substrate to make bilobanone ester dropping pills disintegration rate of the present invention faster than the bilobanone ester dropping pills obtained in prior art, and concrete disintegration time is 6 ~ 10 minutes; Make to act on human body in the drug effect short time, remove the slight illness of patient.
Detailed description of the invention
Describe the present invention below in conjunction with embodiment, the description of this part is only exemplary and explanatory, should not have any restriction to protection scope of the present invention.
The present invention adopts solid dispersion technology, with Polyethylene Glycol by ginkgo flavone and lactone dissolving, suspendible, be emulsified into molecule or microgranule.Polyethylene Glycol is crystallinity water soluble (CO) polymers, the helix of per unit Nei Youliangge unit in molecule, and when medicine solidifies, ginkgo flavone and lactone can be included in the spiral type interstitial space of Polyethylene Glycol just, and the two forms chromic fibrous solid solution; In the process that Polyethylene Glycol is water-soluble, the ginkgo flavone and lactone be scattered in wherein is dissolved, thus improve dissolubility and the dissolution rate of ginkgo flavone and lactone.
The dispersion of Polyethylene Glycol-medicine is in condensed fluid rapidly after cooling, solidify within very short time during low temperature, utilize this characteristic that Polyethylene Glycol-ginkgo flavone and lactone dispersion is made drop pill, the surface area of medicine can be expanded, improve infiltration rate and the bioavailability of ginkgo flavone and lactone, play quick-acting and efficient effect.
The present invention adopts the Polyethylene Glycol of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 three kinds of different molecular weights, separately adopt specific composition scope and the mixed-matrix that forms as medicinal substrate; When ginkgo flavone and lactone solidifies in specific proportions in this medicinal substrate, in the spiral type interstitial space of this medicinal substrate, a large amount of ginkgo flavone and lactone can be comprised, and the dissolution rate of ginkgo flavone and lactone can be made to accelerate.Wherein, the percentage by weight of ginkgo flavone and lactone and medicinal substrate is 10% ~ 18%:82% ~ 90%, and medicinal substrate is made up of by weight 3 ~ 5:1 ~ 1.3:0.4 ~ 0.7 Macrogol 4000, polyethylene glycol 6000 and PEG 8000, the dissolution rate of ginkgo flavone and lactone is very fast; Preferably, the percentage by weight of ginkgo flavone and lactone and medicinal substrate is 13% ~ 15%:85% ~ 87%; Optimum, the percentage by weight of ginkgo flavone and lactone and medicinal substrate is 14%:86%.
In medicinal substrate, preferred scheme is the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4 ~ 5:1.2 ~ 1.3:0.6 ~ 0.7; Optimum, in medicinal substrate, the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4.5:1.2:0.6.
The invention provides table 1 for illustration of different medicinal substrate scheme to the impact of bilobanone ester dropping pills product property.
Table 1 medicinal substrate screens
In addition, when preparing bilobanone ester dropping pills, the ginkgo flavone and lactone raw material adding mixed-matrix being sieved process, selects the ginkgo flavone and lactone of appropriate particle size to be included in further in the spiral type interstitial space of mixed-matrix, form chromic fibrous solid solution.Wherein, it is comparatively suitable that ginkgo flavone and lactone crosses 100 ~ 150 mesh sieves, more excellent, and ginkgo flavone and lactone crosses 120 ~ 130 mesh sieves.
Embodiment
The applicant provides following embodiment in order to illustrate product of the present invention and method, but the technical scheme defined in claims is not by the restriction of following embodiment.
Embodiment 1
(1), in following ratio take each component: 10g ginkgo flavone and lactone and 90g medicinal substrate, medicinal substrate is made up of by weight 3:1.3:0.4 Macrogol 4000, polyethylene glycol 6000 and PEG 8000;
(2), ginkgo flavone and lactone crosses 150 mesh sieves;
(3), in rustless steel container Macrogol 4000, polyethylene glycol 6000 and PEG 8000 mixed, be heated to 70 DEG C, stir, be incubated 3 minutes; Add step (2) sieve after ginkgo flavone and lactone, adding speed is 12 gram/minute, stirs evenly, and continues 65 DEG C of insulations;
, dripping condition: water dropper bore 3.5mm/4.5mm, drip apart from 6-8cm, regulate dropping liquid valve (dripping 50 about per minute of speed), by step (3) mixture instill in the condensed fluid of 16 DEG C of liquid paraffin, obtained drop pill 1000.
Embodiment 2
(1), in following ratio take each component: 18g ginkgo flavone and lactone and 82g medicinal substrate, medicinal substrate is made up of by weight 5:1:0.7 Macrogol 4000, polyethylene glycol 6000 and PEG 8000;
(2), ginkgo flavone and lactone crosses 100 mesh sieves;
(3), in rustless steel container Macrogol 4000, polyethylene glycol 6000 and PEG 8000 mixed, be heated to 85 DEG C, stir, be incubated 2 minutes; Add step (2) sieve after ginkgo flavone and lactone, adding speed is 15 gram/minute, stirs evenly, and continues 60 DEG C of insulations;
, dripping condition: water dropper bore 3.5mm/4.5mm, drip apart from 6-8cm, regulate dropping liquid valve (dripping 50 about per minute of speed), by step (3) mixture instill in the condensed fluid of 13 DEG C of methyl-silicone oils and become drop pill 1000.
Embodiment 3
(1), in following ratio take each component: 15g ginkgo flavone and lactone and 85g medicinal substrate, medicinal substrate is made up of by weight 4:1.3:0.6 Macrogol 4000, polyethylene glycol 6000 and PEG 8000;
(2), ginkgo flavone and lactone crosses 130 mesh sieves;
(3), in rustless steel container Macrogol 4000, polyethylene glycol 6000 and PEG 8000 mixed, be heated to 78 DEG C, stir, be incubated 2 minutes; Add step (2) sieve after ginkgo flavone and lactone, adding speed is 13 gram/minute, stirs evenly, and continues 62 DEG C of insulations;
, dripping condition: water dropper bore 3.5mm/4.5mm, drip apart from 6-8cm, regulate dropping liquid valve (dripping 50 about per minute of speed), by step (3) mixture instill in 17 DEG C of liquid paraffin and dimethicone condensation by mixing liquid and become drop pill 1000.
Embodiment 4
(1), in following ratio take each component: 1g ginkgo flavone and lactone and 88g medicinal substrate, medicinal substrate is made up of by weight 5:1.2:0.7 Macrogol 4000, polyethylene glycol 6000 and PEG 8000;
(2), ginkgo flavone and lactone crosses 120 mesh sieves;
(3), in rustless steel container Macrogol 4000, polyethylene glycol 6000 and PEG 8000 mixed, be heated to 73 DEG C, stir, be incubated 3 minutes; Add step (2) sieve after ginkgo flavone and lactone, adding speed is 12 gram/minute, stirs evenly, and continues 62 DEG C of insulations;
, dripping condition: water dropper bore 3.5mm/4.5mm, drip apart from 6-8cm, regulate dropping liquid valve (dripping 50 about per minute of speed), by step (3) mixture instill in the condensed fluid of 20 DEG C of vegetable oil and become drop pill 1000.
Embodiment 5
(1), in following ratio take each component: 14g ginkgo flavone and lactone and 86g medicinal substrate, medicinal substrate is made up of by weight 4.5:1.2:0.6 Macrogol 4000, polyethylene glycol 6000 and PEG 8000;
(2), ginkgo flavone and lactone crosses 125 mesh sieves;
(3), in rustless steel container Macrogol 4000, polyethylene glycol 6000 and PEG 8000 mixed, be heated to 82 DEG C, stir, be incubated 2.5 minutes; Add step (2) sieve after ginkgo flavone and lactone, adding speed is 14 gram/minute, stirs evenly, and continues 64 DEG C of insulations;
, dripping condition: water dropper bore 3.5mm/4.5mm, drip apart from 6-8cm, regulate dropping liquid valve (dripping 50 about per minute of speed), by step (3) mixture instill in the condensed fluid of 14 DEG C of liquid paraffin and become drop pill 1000.
Following test is carried out in drop pill product sampling gained being prepared by above-described embodiment 1-5.
Pill weight variation measuring method
Check with reference to " Chinese Pharmacopoeia " version in 2010 annex I K, get drop pill 20, accurately weighed gross weight, divided by 20, obtain average ball weight.From 20 drop pill of weighed gross weight, take out 1 successively, accurately weighed weight, obtains each drop pill weight respectively.Calculated weight difference.Drop pill hardness measurement method: pinch with hands and judged.
Disintegration measuring method
With reference to method under " Chinese Pharmacopoeia " version in 2010 annex Ⅻ A inspection technique disintegration item, the disintegration of drop pill is checked, gets drop pill 6, by official method inspection.
Outward appearance roundness method of testing: gross visualization
Test result is as following table 2:
Table 2
In order to more clearly show the advantage of medicinal substrate of the present invention, applicant carried out following contrast test and providing result of the test in table 3.
Comparative example 1
(1), in following ratio take each component: 15g ginkgo flavone and lactone and 85g medicinal substrate, medicinal substrate is made up of by weight 3:1 Macrogol 4000 and polyethylene glycol 6000;
Step (2), (3) and (4) difference step (2), (3) and (4) as described in example 3 above.
Comparative example 2
(1), in following ratio take each component: 15g ginkgo flavone and lactone and 85g medicinal substrate, medicinal substrate is made up of by weight 2:1 Macrogol 4000 and polyethylene glycol 6000;
Step (2), (3) and (4) difference step (2), (3) and (4) as described in example 3 above.
Embodiment 6
(1), in following ratio take each component: 15g ginkgo flavone and lactone and 85g medicinal substrate, medicinal substrate is made up of by weight 4.5:1.2:0.6 Macrogol 4000, polyethylene glycol 6000 and PEG 8000;
Step (2), (3) and (4) difference step (2), (3) and (4) as described in example 3 above
Pill weight variation, drop pill hardness and test disintegration are carried out in the bilobanone ester dropping pills sampling above-mentioned test obtained, and test result is as table 3.
Table 3
Sum up, through the detection to above-mentioned all embodiment products, known ginkgo flavone and lactone and medicinal substrate adopt special ratios, and the bilobanone ester dropping pills that the Polyethylene Glycol that medicinal substrate is three kinds of different molecular weights mixes in specific proportions, good moldability, dripping is smooth, drop pill is smooth, mellow and full, and disintegration rate is fast, is 6 ~ 10 minutes, thus can make to act on human body in the drug effect short time, remove the slight illness of patient.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (14)
1. a bilobanone ester dropping pills, is characterized in that: comprise ginkgo flavone and lactone and medicinal substrate, and both percentage by weights are 10% ~ 18%:82% ~ 90%; Described medicinal substrate is made up of by weight 3 ~ 5:1 ~ 1.3:0.4 ~ 0.7 Macrogol 4000, polyethylene glycol 6000 and PEG 8000.
2. bilobanone ester dropping pills as claimed in claim 1, is characterized in that: the percentage by weight of described ginkgo flavone and lactone and medicinal substrate is 13% ~ 15%:85% ~ 87%.
3. bilobanone ester dropping pills as claimed in claim 2, is characterized in that: the percentage by weight of described ginkgo flavone and lactone and medicinal substrate is 14%:86%.
4. bilobanone ester dropping pills as described in claim 1,2 or 3, is characterized in that: in described medicinal substrate, the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4 ~ 5:1.2 ~ 1.3:0.6 ~ 0.7.
5. bilobanone ester dropping pills as claimed in claim 4, is characterized in that: in described medicinal substrate, the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4.5:1.2:0.6.
6. prepare a method for bilobanone ester dropping pills, said method comprising the steps of:
(1), by the weight ratio of 10% ~ 18%:82% ~ 90% get ginkgo flavone and lactone and medicinal substrate, described medicinal substrate is made up of by weight 3 ~ 5:1 ~ 1.3:0.4 ~ 0.7 Macrogol 4000, polyethylene glycol 6000 and polyethylene glycol-800;
(2), ginkgo flavone and lactone is crossed 100 ~ 150 mesh sieves;
(3), by Macrogol 4000, polyethylene glycol 6000 and PEG 8000 mix, be heated to 70 ~ 85 DEG C, stir, be incubated 2 ~ 3 minutes; Add step (2) sieve after ginkgo flavone and lactone, stir evenly;
(4), become drop pill by step (3) mixture instillation condensed fluid.
7. method as claimed in claim 6, is characterized in that: the percentage by weight of described ginkgo flavone and lactone and medicinal substrate is 13% ~ 15%:85% ~ 87%.
8. method as claimed in claim 6, is characterized in that: the percentage by weight of described ginkgo flavone and lactone and medicinal substrate is 14%:86%.
9. method as claimed in claim 6, is characterized in that: in described medicinal substrate, the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4 ~ 5:1.2 ~ 1.3:0.6 ~ 0.7.
10. method as claimed in claim 6, is characterized in that: in described medicinal substrate, the weight ratio of Macrogol 4000, polyethylene glycol 6000 and PEG 8000 is 4.5:1.2:0.6.
11. methods as claimed in claim 6, is characterized in that: in step (3), ginkgo flavone and lactone adds speed is 12 ~ 15 gram/minute.
12. methods as claimed in claim 6, is characterized in that: the mixture after (3) step stirs evenly continues 60 ~ 65 DEG C of insulations.
13. the method for claim 1, is characterized in that: described condensed fluid is one or more in liquid paraffin, methyl-silicone oil, dimethicone or vegetable oil.
14. the method for claim 1, is characterized in that: ginkgo flavone and lactone crosses 120 ~ 130 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510378999.8A CN104997742B (en) | 2015-07-01 | 2015-07-01 | Bilobanone ester dropping pills and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510378999.8A CN104997742B (en) | 2015-07-01 | 2015-07-01 | Bilobanone ester dropping pills and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104997742A true CN104997742A (en) | 2015-10-28 |
| CN104997742B CN104997742B (en) | 2018-05-29 |
Family
ID=54370791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510378999.8A Active CN104997742B (en) | 2015-07-01 | 2015-07-01 | Bilobanone ester dropping pills and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104997742B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113491672A (en) * | 2020-04-07 | 2021-10-12 | 成都百裕制药股份有限公司 | A dripping pill containing bilobalide as effective component and its preparation method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1552319A (en) * | 2003-06-05 | 2004-12-08 | 许启太 | Ginkgo ketonic ester dripping pill |
| US20050037094A1 (en) * | 2003-07-31 | 2005-02-17 | Xijun Yan | Composition for heart disease, its active ingredients, method to prepare same and uses thereof |
| CN1651007A (en) * | 2004-12-27 | 2005-08-10 | 李宏 | Ginkgo ketone ester drop pill and its preparation method |
| CN1931160A (en) * | 2006-09-28 | 2007-03-21 | 北京汉典中西药研究开发中心 | Ginkgo ketone ester dropping pill and its prepn process |
| CN101791323A (en) * | 2006-09-28 | 2010-08-04 | 北京汉典中西药研究开发中心 | Ginkgo biloba extract dripping pill and preparation method thereof |
-
2015
- 2015-07-01 CN CN201510378999.8A patent/CN104997742B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1552319A (en) * | 2003-06-05 | 2004-12-08 | 许启太 | Ginkgo ketonic ester dripping pill |
| US20050037094A1 (en) * | 2003-07-31 | 2005-02-17 | Xijun Yan | Composition for heart disease, its active ingredients, method to prepare same and uses thereof |
| CN1651007A (en) * | 2004-12-27 | 2005-08-10 | 李宏 | Ginkgo ketone ester drop pill and its preparation method |
| CN1931160A (en) * | 2006-09-28 | 2007-03-21 | 北京汉典中西药研究开发中心 | Ginkgo ketone ester dropping pill and its prepn process |
| CN101791323A (en) * | 2006-09-28 | 2010-08-04 | 北京汉典中西药研究开发中心 | Ginkgo biloba extract dripping pill and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 程宇慧: "滴丸基质和冷凝介质的概况", 《医药工业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113491672A (en) * | 2020-04-07 | 2021-10-12 | 成都百裕制药股份有限公司 | A dripping pill containing bilobalide as effective component and its preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104997742B (en) | 2018-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8597686B2 (en) | Porous cellulose aggregate and formed product composition comprising the same | |
| CN101511347B (en) | Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby | |
| CN106924197B (en) | A bilobalide dripping pill and its preparation method | |
| Ahmed et al. | Development of optimized self-nanoemulsifying lyophilized tablets (SNELTs) to improve finasteride clinical pharmacokinetic behavior | |
| Lin et al. | Incorporation of vitamin E into chitosan and its effect on the film forming solution (viscosity and drying rate) and the solubility and thermal properties of the dried film | |
| HRP20161785T1 (en) | Slow release pharmaceutical composition made of microparticles | |
| CN105916598A (en) | Immediate release film coatings containing medium chain glycerides and substrates coated therewith | |
| Shi et al. | Arginine-stabilized mPEG-PDLLA (50/50) polymeric micelles of docetaxel by electrostatic mechanism for tumor-targeted delivery | |
| CN104997742A (en) | Ginkgo ketonic ester dripping pill and preparation method thereof | |
| Singh et al. | Pharmaceutical characterization of Cassia tora of seed mucilage in tablet formulations | |
| CN101422456A (en) | Medicine combination drop-pills and preparation method and quality detection method thereof | |
| CN107049969A (en) | A kind of prednisolone piece and preparation method thereof | |
| CN110075321A (en) | A kind of Tibetan medicine peace peaceful particle placebo of youngster and preparation method thereof | |
| Soppimath et al. | Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: A novel gastro retentive drug delivery system | |
| ES2765698T3 (en) | Concentrated food composition comprising a pectin gel | |
| CN101633867A (en) | Artificially prepared coumarin and preparation method thereof | |
| CN112168850B (en) | Preparation method of hydrophilic seabuckthorn sterol | |
| AU2015290098B2 (en) | Immediate release abuse deterrent liquid fill dosage form | |
| Lovet et al. | Modification of drug release profile of metronidazole tablet using co-precipitate of irvingia and egg albumin–A proven good technology | |
| Lu et al. | Optimization and evaluation of monodispersed tetrandrine-loaded PLA microspheres prepared with a SPG membrane emulsification technique | |
| Rajpurohit et al. | Hordeum vulgare hull in the design of fast disintegrating tablets | |
| JP7265834B2 (en) | Method for producing plant extract powder | |
| CN112823790B (en) | A ginkgolide dripping pill and its preparation method | |
| Kumar et al. | Preparation and evaluation of sulfamethoxazole solid dispersion employing starch citrate-a new solubility enhancer | |
| Laurent et al. | Formulation and Evaluation of Effervescent Granules Ethanol Extract of Andaliman Fruit (Zanthoxylum acanthopodium DC) with Combination of Citric Acid-Tartaric Acid and Sodium Bicarbonate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |