CN104997726A - External use emulsifiable paste for preventing and treating skin tinea - Google Patents
External use emulsifiable paste for preventing and treating skin tinea Download PDFInfo
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- CN104997726A CN104997726A CN201510410066.2A CN201510410066A CN104997726A CN 104997726 A CN104997726 A CN 104997726A CN 201510410066 A CN201510410066 A CN 201510410066A CN 104997726 A CN104997726 A CN 104997726A
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- tinea
- emulsifiable paste
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- treating skin
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Abstract
The invention belongs to the field of western medicines and relates to external use emulsifiable paste for preventing and treating skin tinea. The external use emulsifiable paste is prepared from 5-15% of terbinafine, 5-10% of chitosan, 3-7 % of Garenoxacin, 0.5-5% of sodium salicylate, 4-8% of chlorphenamine maleate, 5-15% of tretinoin, 3-7% of neomycin sulfate and the balance Vaseline. The external use emulsifiable paste has definite therapeutic effect of treating skin tinea, has high efficiency, reduces recurrence after cure, is safe and has toxic or side effect.
Description
Technical field
The invention belongs to Western medicine field, be specifically related to a kind of medicinal external emulsifiable paste preventing and treating tinea.
Background technology
Tinea mainly refers to the dermatophytosis of close keratoprotein, mainly comprises trichophyton, Microsporon and Epidermophyton, invades skin, hair, deck, the general designation of the infection caused, and is called for short tinea.Comparatively common are psoriasis, tinea capitis, tinea corporis, tinea cruris, tinea manus and pedis, tinea versicolor.Anyly dermatophytosis can occur per capita, be grown up more ill than child Geng Yi, old man's sickness rate of more than 50 years old is higher than adolescence.Live in moist hot area, especially easily suffer from dermatophytosis.Modern way of life also can increase infection chance, and such as bathhouse, swimming pool, Saunas, gymnasium, be dressed in a uniform.
The medicine of current treatment skin tinea has multiple, as Western medicine has PIKANGWANG, daktarin etc., also the ointment that some pure Chinese medicines are made is had, although these medicines can both alleviate the misery of tinea within a certain period of time, and the interim diffusion stoping onset area, but there is its respective limitation, so can not thoroughly cure.
Summary of the invention
The object of the present invention is to provide the medicinal external emulsifiable paste of control tinea that a kind of determined curative effect, cure rate are high, not easily recur.
The technical solution adopted for the present invention to solve the technical problems is: the medicinal external emulsifiable paste of control tinea, formed by the preparation of raw material of following weight percentage ratio: terbinafine 5-15%, chitosan 5-10%, T-3811 3-7%, sodium salicylate 0.5-5%, chlorphenamine maleate 4-8%, tretinoin 5-15%, polygynax 3-7%, surplus is vaseline.
Preferably, the medicinal external emulsifiable paste of control tinea, is formed by the preparation of raw material of following weight percentage ratio: terbinafine 10%, chitosan 8%, T-3811 5%, sodium salicylate 2%, chlorphenamine maleate 4%, tretinoin 10%, polygynax 5%, surplus is vaseline.
According to a conventional method above-mentioned raw materials is mixed into paste.
The primary efficacy of above-mentioned each raw material is as follows:
Terbinafine: be propylamine antifungal agent, the squalene epoxidase enzymes in Antifungi cell ergosterol building-up process, and zamene is accumulated in cell and plays bactericidal action.There is broad-spectrum antifungal effect, have bactericidal action to dermatophytes, then bacteriostasis is played to Candida albicans.Be applicable to skin, nail infection that superficial fungi causes, as tinea corporis, tinea cruris, tinea pedis, tinea unguium and skin candida albicans infection that trichophyton, Canis familiaris L. sporidiole bacteria, acrothesium floccosum etc. cause.
Chitosan: have good antibacterial activity, can suppress the growth and breeding of some funguses, antibacterial and virus.Antimicrobial mechanism has be polycation due to chitosan at three: one, is easy to the group effect that fungal cell surface is electronegative, thus changes mobility and the permeability of pathogen cell membrane; Two is copying and transcribing of interference DNA; Three is block pathogen metabolism.
T-3811: stronger than Gatifloxacin (gatifloxacin), ciprofloxacin, levofloxacin effect, antimicrobial spectrum is wider.But it is lower to the activity of Grain-negative enterobacteria and bacillus pyocyaneus.
Sodium salicylate: can be used for treating various chronic dermatosis, such as dermatomycosis (tinea), rhagadia manus et pedis, psoriasis and chronic dermatitis.
Chlorphenamine maleate: be applicable to skin allergy: urticaria, eczema, dermatitis, drug eruption, skin pruritus, neurodermatitis, insect bite disease, solar dermatitis, also can be used for allergic rhinitis, medicine and food anaphylaxis.
Tretinoin: tretinoin is the metabolic intermediate of vitamin A in body, the metabolism such as the growth of major effect bone and promotion epithelial hyperplasia, differentiation, cutin dissolving.Be used for the treatment of the diseases such as acne vulgaris, psoriasis, ichthyosis, lichen planus, pityriasis rubra pilaris, follicular keratosis, squamous cell carcinoma and melanoma.
Polygynax: be a kind of aminoglycoside antibiotics, has good antibacterial action to the enterobacteriaceae lactobacteriaceae such as staphylococcus (methicillin-sensitivity strain), corynebacterium, escherichia coli, Klebsiella, Proteus.
The present invention has following beneficial effect: medicinal external emulsifiable paste treatment tinea determined curative effect of the present invention, effective percentage is high, not easily recurs more, safe without toxic side effect.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
The medicinal external emulsifiable paste of control tinea, formed by the preparation of raw material of following weight percentage ratio: terbinafine 10%, chitosan 8%, T-3811 5%, sodium salicylate 2%, chlorphenamine maleate 4%, tretinoin 10%, polygynax 5%, surplus is vaseline.
According to a conventional method above-mentioned raw materials is mixed into paste.
Embodiment 2
The medicinal external emulsifiable paste of control tinea, formed by the preparation of raw material of following weight percentage ratio: terbinafine 5%, chitosan 10%, T-3811 6%, sodium salicylate 4%, chlorphenamine maleate 8%, tretinoin 15%, polygynax 6%, surplus is vaseline.
According to a conventional method above-mentioned raw materials is mixed into paste.
Embodiment 3
The medicinal external emulsifiable paste of control tinea, formed by the preparation of raw material of following weight percentage ratio: terbinafine 15%, chitosan 7%, T-3811 3%, sodium salicylate 5%, chlorphenamine maleate 5%, tretinoin 12%, polygynax 3%, surplus is vaseline.
According to a conventional method above-mentioned raw materials is mixed into paste.
Embodiment 4
The medicinal external emulsifiable paste of control tinea, formed by the preparation of raw material of following weight percentage ratio: terbinafine 13%, chitosan 5%, T-3811 7%, sodium salicylate 0.5%, chlorphenamine maleate 6%, tretinoin 5%, polygynax 7%, surplus is vaseline.
According to a conventional method above-mentioned raw materials is mixed into paste.
Clinical data
Physical data: accept for medical treatment altogether tinea patient 320 example, wherein male 149 example, women 171 example, age 9-73 year.
Therapeutic Method: medicinal external emulsifiable paste of the present invention smears affected part, twice on the one 7 days is a course for the treatment of.
Curative effect judging standard:
Cure: clinical symptoms all disappears, illing skin recovers normal, within more than 1 year, does not recur.
Effective: clinical symptoms takes a turn for the better or alleviates.
Invalid: clinical symptoms does not alleviate and even increases the weight of.
Therapeutic outcome: with medicinal external emulsifiable paste of the present invention to the therapeutic outcome of tinea patient as following table:
| Sick kind | Number of cases | Cure | Effectively | Invalid | Cure rate/% | Total effective rate/% |
| Psoriasis | 72 | 53 | 11 | 8 | 73.6 | 88.9 |
| Tinea capitis | 53 | 47 | 3 | 3 | 88.7 | 94.3 |
| Tinea corporis | 65 | 51 | 8 | 6 | 78.5 | 90.8 |
| Tinea cruris | 45 | 34 | 5 | 6 | 75.6 | 86.7 |
| Tinea manus and pedis | 50 | 41 | 6 | 3 | 82 | 94 |
| Tinea versicolor | 35 | 23 | 7 | 5 | 65.7 | 85.7 |
As seen from the above table, medicinal external emulsifiable paste of the present invention all has good therapeutic effect to common tinea, not easily recurs.
Model case 1
Grandson so-and-so, female, 22 years old, suffers from " homeliness type psoriasis " more than 3 years.Once invalid many hospitalizes, the medicine short-term also once taken containing hormone was cured, but shortly more serious recurrence.After being introduced, after treating a course for the treatment of with medicinal external emulsifiable paste of the present invention, pruritus alleviates, and skin lesion disappears 50%.Continual cure two the whole body skin lesion course for the treatment of all disappears, and has again recovered the skin of pale delicacy originally.Advise its continual cure one consolidate curative effect course for the treatment of, follow up a case by regular visits to and do not recur for 2 years.
Model case 2
Hu, 12 years old, there is the tinea block of white, desquamation from level to level in female above forehead.The hair at other position is all pitch-black shinny, and the hair of lesion is very easy to fracture, come off.Suffer from tinea capitis after diagnosing.After treating a course for the treatment of with medicinal external emulsifiable paste of the present invention afterwards, desquamation symptom alleviates, and alopecia is controlled, and continual cure two recoveries from illness course for the treatment of, follow up a case by regular visits to and do not recur for 2 years.
Model case 3
Temperature certain, man, 41 years old, two months ago, there is the vesicle of syringe needle to small rice grain size in back local skin, afterwards vesicle dry after there is desquamation, and expand to surrounding gradually, with the passing of time skin has desquamation and pigmentation, skin lesion peripheral part inflammation is obvious.Patient uses corticosteroid ointment privately, and have an effect at first, the state of an illness was more and more serious afterwards.On inspection, skin lesion edge enlivens, and pimpling, vesicle and desquamation, circular shape, color is scarlet, and with obvious pruritus, is diagnosed as tinea corporis.After treating a course for the treatment of with medicinal external emulsifiable paste of the present invention, symptom greatly alleviates, and the continual cure recovery from illness course for the treatment of, follows up a case by regular visits to and do not recur for 1 year.
Model case 4
Liu so-and-so, man, 52 years old, the year before during a foot bath find sole have several little dark red point, do not ache and do not itch, do not note very much at that time, later small red dot start spread, occur that needle point arrives pinhead-sized deep-seated vesicles, and start to itch, heel is dry and cracked.Arrive local Hospital of Skin Diseases afterwards, local doctor is diagnosed as: palm toe impetigo, give plaster treatment, the state of an illness constantly repeatedly, finally smear plaster and also don't work, and area diffusive infection is to hand.After treating a course for the treatment of with medicinal external emulsifiable paste of the present invention, dead bark starts to come off, also no longer pruritus, and continual cure was fully recovered after the course for the treatment of, followed up a case by regular visits to and did not recur for 2 years.
Claims (2)
1. prevent and treat the medicinal external emulsifiable paste of tinea, it is characterized in that, formed by the preparation of raw material of following weight percentage ratio: terbinafine 5-15%, chitosan 5-10%, T-3811 3-7%, sodium salicylate 0.5-5%, chlorphenamine maleate 4-8%, tretinoin 5-15%, polygynax 3-7%, surplus is vaseline.
2. the medicinal external emulsifiable paste of control tinea as claimed in claim 1, it is characterized in that, formed by the preparation of raw material of following weight percentage ratio: terbinafine 10%, chitosan 8%, T-3811 5%, sodium salicylate 2%, chlorphenamine maleate 4%, tretinoin 10%, polygynax 5%, surplus is vaseline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510410066.2A CN104997726A (en) | 2015-07-14 | 2015-07-14 | External use emulsifiable paste for preventing and treating skin tinea |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510410066.2A CN104997726A (en) | 2015-07-14 | 2015-07-14 | External use emulsifiable paste for preventing and treating skin tinea |
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| CN104997726A true CN104997726A (en) | 2015-10-28 |
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| CN201510410066.2A Pending CN104997726A (en) | 2015-07-14 | 2015-07-14 | External use emulsifiable paste for preventing and treating skin tinea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748473A (en) * | 2016-03-01 | 2016-07-13 | 广州市东来生物科技有限公司 | Tetracycline family compound formula, preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998599A (en) * | 2006-01-12 | 2007-07-18 | 张松 | Compound terbinafine and root of large flowered skullcap cream and its preparing method |
| CN103768097A (en) * | 2014-02-25 | 2014-05-07 | 南京农业大学 | Copper-loaded attapulgite clay, preparation method and use thereof |
-
2015
- 2015-07-14 CN CN201510410066.2A patent/CN104997726A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998599A (en) * | 2006-01-12 | 2007-07-18 | 张松 | Compound terbinafine and root of large flowered skullcap cream and its preparing method |
| CN103768097A (en) * | 2014-02-25 | 2014-05-07 | 南京农业大学 | Copper-loaded attapulgite clay, preparation method and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴志华等: "《皮肤性病学dermatology and venerology》", 30 June 2013 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748473A (en) * | 2016-03-01 | 2016-07-13 | 广州市东来生物科技有限公司 | Tetracycline family compound formula, preparation method and application thereof |
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Application publication date: 20151028 |
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