CN104984774B - Oil displacing microfluidic apparatus device and application thereof - Google Patents
Oil displacing microfluidic apparatus device and application thereof Download PDFInfo
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- CN104984774B CN104984774B CN201510428038.3A CN201510428038A CN104984774B CN 104984774 B CN104984774 B CN 104984774B CN 201510428038 A CN201510428038 A CN 201510428038A CN 104984774 B CN104984774 B CN 104984774B
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Abstract
The invention provides an oil displacing microfluidic apparatus device and application thereof. The microfluidic apparatus is composed of a glass tube which is different in diameter at two ends; the diameter of the fine end of the glass tube is 1.3-1.7mm and the diameter of the thick end of the glass tube is 3.7-4.3mm. The cost of the microfluidic apparatus is greatly lowered, and the microfluidic apparatus is convenient to manufacture and install; liquid drops are prevented from being evaporated in a moving process. The problem that in conventional microfluid transportation, the microfluid can be only transferred from the fine end to the thick end is overcome. If the liquid drops are placed in a taperless glass tube, the liquid drops cannot move. If the liquid drops are placed on the upper surface of a cone-shaped rod, the liquid drops will move from the fine end to the thick end. According to the device provided by the invention, an oil product is transported from the thick end to the fine end by using a simple cone-shaped tube. The product provided by the invention is simple and feasible, and the liquid drops can be driven to move well without adopting an acousto-optic electromagnet.
Description
Technical field
The invention belongs to microfluid transportation art, more particularly to oil product conveying microfluidic device.
Background technology
The autogenic movement of drop has for the displacement of reservoir oil in oil exploitation, drug delivery, self-cleaning function of biomimetic material etc.
Play an important role.The simple microfluidic device of design is the basic premise for realizing drop autogenic movement.But it is most of at present
Drop driving means are all based on greatly the external effect such as electric field, magnetic field, chemical reagent, rarely directly pass through simple geometric structures
The easy device optimized to realize this function.
Patent of invention micro fluid dynamcis and speed control unit and method, application number：200510135579, the patent is disclosed
A kind of microfluid drive, can drive the flowing of fluid in microfluid system, it is characterised in that comprising syringe, comprising
One cavity and a piston, abovementioned cavity have an opening, and aforementioned piston can be moved in cavity；One piston positioning means, are arranged at
Inside or outside abovementioned cavity, aforementioned piston is made to stay in the position being previously set；One connection unit, is to connect syringe
With microfluid system；And one hinder element, it is arranged inside abovementioned cavity, inside microfluid system or inside connection unit；
Wherein when aforementioned piston is moved to the aforementioned position being previously set, the pressure differential between cavity and microfluid system is caused, can be driven
The flowing of fluid in microfluid system, and by the aforementioned use for hindering element, the flowing of fluid in microfluid system can be slowed down
Speed.
Application number：200880015296.7 the applying date：2008-04-04, patent describe the spy relevant with microfluidic device
Determine embodiment, the microfluidic device can be used for cell sensing, count, and/or sort.Specific aspect is related to from thick
The micro manufacturing device of individual cells type is distinguished in close cell colony.One specific embodiment is related to device and uses the dress
Put from complete, not diluted blood sample sensing, the method for counting, and/or sorting leucocyte.
Drop is positioned over above an elongated tapered rod, then drop can spontaneously from thin under surface tension effects
One end moves to thick one end.The processing of tapered rod is relatively difficult, and droplet size is too little, and evaporation is very fast, high cost.
One capillary two parts are chemically modified, left side is hydrophilic, and right side is hydrophobic.Drop is put in pipe,
Then drop can move to hydrophilic position from hydrophobic position.Preparing for the capillary pipe structure of chemical modification is relatively difficult, high cost.
The content of the invention
There is provided a kind of lower-cost microfluidic device, it is not necessary to chemical modification or applied external force, spontaneous can drive
Dynamic liquid drop movement.Droplet size can be millimeter magnitude with larger, so as to avoid droplets from evaporation in motion process.
Technical scheme composition is as follows：
The microfluidic device is that two ends diameter different glass pipe is constituted, a diameter of 1.3- of the glass tube taper end
1.7mm, butt diameter are 3.7-4.3mm.Microfluidic device length is 2mm or so.
The preferred 1.4-1.6mm of diameter of the glass tube taper end, butt diameter is 3.9-4.1mm.Microfluidic device length
For 2mm.A diameter of 1.5mm of the glass tube taper end, butt diameter is 4mm.Microfluidic device length is 2mm.
The butt end of described microfluidic device arranges oil product entrance or is not provided with.
The taper end of the microfluidic device can connect concrete transmission terminal.
The microfluidic device transport is oils product, and so-called oils product is mineral oil.
After oil product drop is built in microfluidic device oil product porch, drop is rapid (1 second from the butt end of microfluidic device
Within) it is transported to taper end.
Using method：Place in the butt end of microfluidic device or add target oil droplet, oil droplet slides into automatically taper end and passes
It is sent to purpose terminal.
Beneficial effect：
Substantially reduce the cost of such microfluidic device, it is manufacture, easy for installation；
Avoid droplets from the evaporation in motion process.
Overcome and butt end can only be transferred to from taper end present in conventional microfluidic transport, if drop is placed on zero draft
In glass tube, then drop cannot be moved.If drop is placed on a tapered rod upper surface, drop can be moved to slightly from taper end
End；It is of the invention then can using simple conical pipe realize oil product from butt end transport to taper end.
Product of the present invention is simple, it is not necessary to adopt acousto-optic electromagnetism good with driving liquid drop movement.
Specific embodiment
Transporting oil products are edible oil, silicone oil etc.；Speed is both greater than the 2mm/ seconds；In practical application, oil is needed from rock mass hole
It is middle to be displaced, so in experiment, the 3D printing of rock mass hole is into above-mentioned tapered tubular, so that it may so that oil is more prone to drive away out.Medicine
During thing is transported, it is required that medicine is automatically moved to specific position, said apparatus can also be adopted.Viral diagnosis are also such as
This, has dissolved virus and has been also required to be transported to ad-hoc location in drop.
Claims (9)
1. a kind of microfluidic device, the microfluidic device are two ends diameter different glass pipe composition, the glass tube taper end
A diameter of 1.3-1.7mm, butt diameter are 3.7-4.3mm.
2. microfluidic device according to claim 1, it is characterised in that the glass length of tube is 2mm.
3. microfluidic device according to claim 1, it is characterised in that a diameter of 1.4-1.6mm of the glass tube taper end.
4. microfluidic device according to claim 1, it is characterised in that the butt diameter is 3.9-4.1mm.
5. microfluidic device according to claim 1, it is characterised in that a diameter of 1.5mm of the glass tube taper end, butt end
A diameter of 4mm.
6. microfluidic device according to claim 1, it is characterised in that the butt end of described microfluidic device arranges oil product and enters
Mouthful.
7. microfluidic device according to claim 1, it is characterised in that the taper end of the microfluidic device can connect specifically
Transmission terminal.
8. microfluidic device according to claim 1, it is characterised in that the microfluidic device transport is oils product, institute
Meaning oils product is mineral oil.
9. the using method of microfluidic device according to claim 1, comprises the steps：Using method：In Microfluidizer
The butt end of part is placed or adds target oil droplet, and oil droplet slides into automatically taper end and is sent to purpose terminal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510428038.3A CN104984774B (en) | 2015-07-20 | 2015-07-20 | Oil displacing microfluidic apparatus device and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510428038.3A CN104984774B (en) | 2015-07-20 | 2015-07-20 | Oil displacing microfluidic apparatus device and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104984774A CN104984774A (en) | 2015-10-21 |
| CN104984774B true CN104984774B (en) | 2017-03-22 |
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| CN201510428038.3A Active CN104984774B (en) | 2015-07-20 | 2015-07-20 | Oil displacing microfluidic apparatus device and application thereof |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2376226T3 (en) * | 2008-12-18 | 2018-10-15 | Opko Diagnostics Llc | IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES |
| JP6016217B2 (en) * | 2011-10-25 | 2016-10-26 | インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | Microfluidic device and method of making microfluidic device |
| CN103121660B (en) * | 2013-03-06 | 2015-10-28 | 江苏科技大学 | Towards glass-based bionic microchannel processing unit (plant) and the processing method of microfluid system |
| CN104511320A (en) * | 2013-09-27 | 2015-04-15 | 王来 | A liquid-drop-generation capillary microfluidic chip and a preparing method thereof |
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