CN104949967B - The kit of tyrosine phenol metabolism thing in detection human urine - Google Patents
The kit of tyrosine phenol metabolism thing in detection human urine Download PDFInfo
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Abstract
The present invention relates to detect the kit of tyrosine phenol metabolism thing in human urine, in this detection human urine, the kit of tyrosine phenol metabolism thing includes phenol core developer and separates film, described separation film is the perforated membrane that aperture is less than 0.1 micron, and described separation film is 1:50 100 with the volume ratio of urine to be measured.In detection human urine, the kit of tyrosine phenol metabolism thing can detect tyrosine phenol metabolism thing effectively, such that it is able to accurately infer whether human body suffers from cancer.
Description
Technical field
The present invention relates to detect the kit of tyrosine phenol metabolism thing in human urine, further relate to urine detection method, in particular it relates to international Patent classificating number G01N21/00.
Background technology
Early detection is the key for the treatment of tumour, and the development of tumour is divided into five stages: optimum, tumour cell starting period, tumour in early days, tumour mid-term, late period.The fearful part of cancer, in that front three phases, iconography cannot detect at all, even if having arrived tumour mid-term, the most very professional doctor just can measure with more advanced equipment.The research of the World Health Organization is thought: the cancer of current 1/3 is preventable；The cancer of 1/3 can extend patient vitals by active treatment；The cancer of 1/3 can be by early detection, early diagnosis, early treatment and fully recover.Characteristic amino acid metabolic disorder in the urine of cancer patient, produces substantial amounts of tyrosine phenol metabolism thing.The content of detection tyrosine phenol metabolism thing, may infer that whether human body suffers from cancer.
In urine, tryptophan, the detection of tyrosine phenol metabolism thing are easily disturbed by other compounds, cause in some cases, it is impossible to realize accurately judging whether human body suffers from cancer.
Summary of the invention
In order to solve above-mentioned technical problem, on the one hand, the invention provides and a kind of detect the kit of tyrosine phenol metabolism thing in human urine, in this detection human urine, the kit of tyrosine phenol metabolism thing includes phenol core developer and separates film, described separation film is the perforated membrane that aperture is less than 0.1 micron, and described separation film is 1:50-100 with the volume ratio of urine to be measured.
Described phenol core developer is containing mercury ion, the solution of mercurous ion.
Described perforated membrane is several layers, and described perforated membrane includes 100 weight portion polyolefin and 30-150 weight portion organic filler.
Described polyolefin is polypropylene-based resin.
Described polypropylene-based resin is at least one in the copolymer of polypropylene or propylene and other alkene.
Described organic filler is hypophosphites, and the structure of described hypophosphites is as follows:
Wherein, R1 and R2 is to have the straight chain of 1-6 carbon atom or branched-alkyl or aryl independently of one another；M is the nitrogen base of Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K or protonation；M is the integer of 1-4.
One or more in aluminum diethylphosphinate, trimethylethyl phosphinic acids aluminium, diphenyl phosphonic acid aluminium, diethyl phosphinic acids zinc, Methylethyl phosphinic acids zinc, diphenyl phosphonic acid zinc, diethyl phosphinic acids oxygen titanium, diethyl phosphinic acids titanium, Methylethyl phosphinic acids oxygen titanium, Methylethyl phosphinic acids titanium, diphenyl phosphonic acid oxygen titanium, diphenyl phosphonic acid titanium of described organic filler.
The particle diameter of described organic filler is 1-5000 nanometer.
Described polyolefinic fusion temperature is 130-150 degree Celsius, and described organic filler keeps solid-state when 130 degrees Celsius.
Urine detection method, comprises the following steps:
Urine is used aforesaid separation UF membrane, obtains urine separation liquid,
Urine separation liquid is contacted with phenol core developer.
It is more readily understood the above-mentioned of the application and other features, aspect and advantage with reference to described further below.
Detailed description of the invention
Unless otherwise defined, all technology used herein and scientific terminology have the identical implication being generally understood that with one skilled in the art of the present invention.When there is contradiction, it is as the criterion with the definition in this specification.
Term as used herein " by ... preparation " and " comprising " synonym.Term used herein " comprises ", " including ", " having ", " containing " or its other deformation any, it is intended that cover the including of non-exclusionism.Such as, comprise the composition of listed elements, step, method, goods or device and be not necessarily solely those key elements, but other not expressly listed key element or the intrinsic key element of this kind of composition, step, method, goods or device can be included.
Conjunction " Consists of " gets rid of any key element, step or component do not pointed out.If in claim, this phrase will make claim be closed so that it is does not comprise the material in addition to the material that those describe, but except relative customary impurities.When being rather than immediately following during phrase " Consists of " occurs in the clause of claim main body after theme, it is only limited to the key element described in this clause；Other key element is not excluded outside as overall described claim.
During the Range Representation that equivalent, concentration or other value or parameter limit with scope, preferred scope or a series of upper limit preferred value and lower preferable values, this is appreciated that and specifically discloses all scopes formed by arbitrary pairing of any range limit or preferred value and any range lower limit or preferred value, regardless of whether whether this scope separately discloses.Such as, when disclosing scope " 1 to 5 ", described scope should be interpreted as including scope " 1 to 4 ", " 1 to 3 ", " 1-2 ", " 1-2 and 4-5 ", " 1-3 and 5 " etc..When number range is described in this article, unless otherwise indicated, otherwise this scope is intended to include its end value and all integers within the range and mark.
Additionally, the indefinite article " a kind of " before key element of the present invention or component and " one " quantitative requirement (i.e. occurrence number) unrestriction to key element or component.Therefore " one " or " a kind of " should be read as including one or at least one, and the key element of singulative or component also include plural form, unless the obvious purport of described quantity refers to singulative.
The kit of tyrosine phenol metabolism thing in detection human urine, in this detection human urine, the kit of tyrosine phenol metabolism thing includes phenol core developer and separates film, described separation film is the perforated membrane that aperture is less than 0.1 micron, and described separation film is 1:50-100 with the volume ratio of urine to be measured.
Phenol core developer
Phenol core developer of the present invention refers to and those developers of phenolic groups generation chromogenic reaction.
Such as, there is compound energy and the FeCl of the structure (-C=C-OH) structure that hydroxyl is connected with sp2 hydbridized carbon atoms3The aqueous solution show special color.So FeCl can be used3As phenol core developer.
It addition, millon reagent can also be as the phenol core developer of the present invention.
Gelatin can be used as phenol core developer, takes aqueous solution 1ml to be measured, adds sodium chloride bright solution 2-3 and drips, i.e. generates white depositions.
Bromine water can be used as phenol core developer: takes aqueous solution 1ml to be measured, adds bromine test solution 1-2 and drips, and generates white or sediment,
Vanillic aldehyde-acid blend can be used as phenol core developer: takes aqueous solution point to be measured on filter paper, dry after, spray or drip vanillic aldehyde-hydrochloric acid test solution, presenting punctation.
Additionally, 10% liquor ferri trichloridi；1% ferric trichloride ethanol solution and 1% potassium ferricyanide aqueous solution (1:1) can also can show blue-violet spot as the developer of phenol core containing phenol.
Certainly, phenol core developer of the present invention is not limited to above-mentioned developer, major part metal ion, all can under certain conditions with phenol generation chromogenic reaction.So, any developer that can develop the color with phenol generation all can be as the phenol core developer of the present invention.
As the preferred technical scheme of one, the present invention can select containing mercury ion, the salpeter solution of mercurous ion.
Perforated membrane
Described perforated membrane is several layers, and described perforated membrane includes 100 weight portion polyolefin and 30-150 weight portion organic filler.
Polyolefin
The polyolefin used in the present invention is the polymer containing the monomeric unit deriving from alkene.Can illustrate such as: polythylene resin, ethylene-carboxylic acid's alkenyl esters copolymer resin, ethene-unsaturated carboxylic acid alkyl ester copolymer resin, polypropylene-based resin, polybutene resinoid, poly-(4-methyl-1-pentene) resinoid etc..
As polythylene resin, it may be preferred to illustrate polyethylene.It is not particularly limited as polyethylene, it is possible to use low density polyethylene (LDPE), LLDPE, medium density polyethylene, high density polyethylene (HDPE) etc..
As " alkenyl carboxylate " of ethylene-carboxylic acid's alkenyl esters copolymer resin, can illustrate: vinyl acetate, propionate, vinyl butyrate, methylvinyl acetate, allyl acetate etc..Wherein preferred vinyl acetate.As ethylene-carboxylic acid's alkenyl esters copolymer resin, specifically, particularly preferred vinyl-vinyl acetate copolymer.
As " unsaturated carboxylic acid alkyl ester " of ethene-unsaturated carboxylic acid alkyl ester copolymer resin, can illustrate: methyl acrylate, ethyl acrylate, propyl acrylate, methyl methacrylate, EMA, propyl methacrylate etc..Wherein, preferably methyl acrylate, methyl methacrylate.As ethene-unsaturated carboxylic acid alkyl ester copolymer resin, specifically, particularly preferred ethylene-methyl acrylate copolymer, ethylene methyl methacrylate copolymer.
As polypropylene-based resin, it may be preferred to illustrate: polypropylene or propylene and the copolymer of other alkene.As " other alkene " in this, it may be preferred to illustrate: ethene, butylene, amylene, hexene, octene etc..These " other alkene " can be used alone a kind or are applied in combination two or more (that is, forming the copolymer with propylene).As polypropylene-based resin, more specifically, optimization polypropylene or propylene-ethylene copolymers, propylene-ethylene-butene copolymer, propene-1-butene copolymer, butene-hexene copolymer, propylene-octene Copolymer etc., wherein particularly preferred polypropylene or propylene-ethylene copolymers.
Polyolefin can be used alone a kind or is applied in combination two or more.In polyolefin, from the viewpoint of excellent with the compatibility of aliphatic polycarbonate resin, optimization polypropylene resinoid, is more preferably selected from least one in the group being made up of the copolymer of polypropylene and propylene and other alkene, further preferably uses propylene-ethylene copolymers.
As polyolefinic manufacture method, can enumerate: use the initiators such as peroxide by the method for alkene radical polymerization；By vapor phase method, solwution method etc. by the method etc. of olefinic polymerization in the presence of polymerization catalyst.As polymerization catalyst, it is possible to use Ziegler-Natta catalyst and metallocene catalyst etc..
Organic filler
One of preferred version as the present invention, described organic filler is selected from polymer beads or organic salt particle.
One of preferred version as the present invention, polymer beads such as poly methyl methacrylate particle, polyimide particles, polycarbonate pellets.
Organic salt particle, such as various organic slaines, such as magnesium salts, aluminium salt etc..
One of preferred version as the present invention, described organic filler is hypophosphites, and the structure of described hypophosphites is as follows:
Wherein, R1 and R2 is to have the straight chain of 1-6 carbon atom or branched-alkyl or aryl independently of one another；M is the nitrogen base of Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K or protonation；M is the integer of 1-4.
This organic filler containing phosphorus atoms has high phosphorus content, do not hydrolyze and hydrophobic, this organic filler can submit preferably separation effectively to, for the urea in urine, metal ion, the oxidable compound of part there is certain adsorption capacity, but absorption the most less for the compound containing phenol core.
One of preferred version as the present invention, one or more in aluminum diethylphosphinate, trimethylethyl phosphinic acids aluminium, diphenyl phosphonic acid aluminium, diethyl phosphinic acids zinc, Methylethyl phosphinic acids zinc, diphenyl phosphonic acid zinc, diethyl phosphinic acids oxygen titanium, diethyl phosphinic acids titanium, Methylethyl phosphinic acids oxygen titanium, Methylethyl phosphinic acids titanium, diphenyl phosphonic acid oxygen titanium, diphenyl phosphonic acid titanium of described organic filler.
One of preferred version as the present invention, the particle diameter of described organic filler is 1-5000 nanometer.
One of preferred version as the present invention, described polyolefinic fusion temperature is 130-150 degree Celsius, and described organic filler keeps solid-state when 130 degrees Celsius.After polyolefin is blended in 130 DEG C of organic fillers keeping solid-states and stretch, can make the interfacial separation between resin and filler, form pore such that it is able to preparation has the perforated membrane of certain separation.
The perforated membrane of the present invention is prepared by stretch processes.
Urine detection method, comprises the following steps:
Urine is used aforesaid separation UF membrane, obtains urine separation liquid,
Urine separation liquid is contacted with phenol core developer.
The present invention uses the perforated membrane that aperture is less than 1 micron, and this separation film has a good adsorption capacity to the most of organic matter in urine, but the adsorption capacity for the higher tryptophan of segment polarity, tyrosine phenol metabolism thing is more weak.Containing higher than ordinary person 5-50 times, the tryptophan of even 100 times, tyrosine phenol metabolism thing in the urine of cancer patient, so easily by perforated membrane, timely part test substance is adsorbed, and also can realize detection.
Using described separation film is 1:50-100 with the volume ratio of urine to be measured so that separates other organic matters in basic absorption urine in the hole of film, is more beneficial for organic separation to be measured.
Embodiment 1, the kit of tyrosine phenol metabolism thing in detection human urine, in this detection human urine, the kit of tyrosine phenol metabolism thing includes phenol core developer and separates film, described separation film is the perforated membrane that aperture is less than 0.1 micron, and described separation film is 1:50-100 with the volume ratio of urine to be measured.
Embodiment 2, described phenol core developer is containing mercury ion, the solution of mercurous ion.
Embodiment 3, described perforated membrane is several layers, and described perforated membrane includes 100 weight portion polyolefin and 30-150 weight portion organic filler.
Embodiment 4, described polyolefin is polypropylene-based resin.
Embodiment 5, described polypropylene-based resin is at least one in the copolymer of polypropylene or propylene and other alkene.
Embodiment 6, described organic filler is hypophosphites, and the structure of described hypophosphites is as follows:
Wherein, R1 and R2 is to have the straight chain of 1-6 carbon atom or branched-alkyl or aryl independently of one another；M is the nitrogen base of Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K or protonation；M is the integer of 1-4.
Embodiment 7, one or more in aluminum diethylphosphinate, trimethylethyl phosphinic acids aluminium, diphenyl phosphonic acid aluminium, diethyl phosphinic acids zinc, Methylethyl phosphinic acids zinc, diphenyl phosphonic acid zinc, diethyl phosphinic acids oxygen titanium, diethyl phosphinic acids titanium, Methylethyl phosphinic acids oxygen titanium, Methylethyl phosphinic acids titanium, diphenyl phosphonic acid oxygen titanium, diphenyl phosphonic acid titanium of described organic filler.
Embodiment 8, the particle diameter of described organic filler is 1-5000 nanometer.
Embodiment 9, described polyolefinic fusion temperature is 130-150 degree Celsius, and described organic filler keeps solid-state when 130 degrees Celsius.
Embodiment 10, urine detection method, comprise the following steps:
Urine is used aforesaid separation UF membrane, obtains urine separation liquid,
Urine separation liquid is contacted with phenol core developer.
Hereinafter, by embodiment, the present invention is explained in more detail, it should be appreciated that these embodiments be only illustrate and nonrestrictive.Illustrating without other, raw materials used is all commercially available.
The present invention is described in detail referring to several examples.
Separate film A1 KOCH MF-618 aperture less than 0.1 micron.
Separate film A2 KOCH MF-601 aperture less than 0.4 micron.
Separate film A3 KOCH HF-131 milipore filter.
After separation film A4 is mixed by 100 weight account polyethylenes (middle petrochemical industry HDPE) 80 weight portion PMMA microsphere (micro-nano 20 microns of Suzhou intelligence), make sheet and biaxial tension obtains.
After separation film A5 is mixed by 100 weight account polyethylenes-polypropylene copolymer (CX9530) 80 weight portion PMMA microsphere (micro-nano 20 microns of Suzhou intelligence), make sheet and biaxial tension obtains.
After separation film A6 is mixed by 100 weight account polyethylenes-polypropylene copolymer (CX9530) 80 weight portion aluminum diethylphosphinate, make sheet and biaxial tension obtains.
Phenol core developer: the mercuric sulfate of 0.1g/ml, the mercuric nitrate of 1g/ml, the volume ratio of nickel nitrate solution of 0.1g/ml are 1:1:1.
Artificial urine (urine of normal person adds 5-HIAA, 5-HIAA content 15mg/L) is used aforesaid separation UF membrane, obtains urine separation liquid, urine separation liquid is mixed with phenol core developer, check whether chromogenic reaction.
Being found through experiments, the volume ratio separating film and urine is 1:100, uses separation film A2, A3 that chromogenic reaction cannot occur.Then there is chromogenic reaction in A1.Visible big aperture makes 5-HIAA all be adsorbed by separation film.
Distribution uses A4, A5, A6 to separate film, and the volume ratio separating film and urine is 1:50, and through the clinical verification of tumour hospital, 400 examples are in the cancer patient that histology is made a definite diagnosis, and accuracy rate (coincidence rate) respectively reaches 91.6%, 91.1%, 96.2%.
Using A4, A5, A6 to separate film, the volume ratio separating film and urine is 1:150, and through the clinical verification of tumour hospital, 400 examples are in the cancer patient that histology is made a definite diagnosis, and accuracy rate (coincidence rate) respectively reaches 87.9%, 87.0%, 93.5%.
The above, only presently preferred embodiments of the present invention, it is not intended to limit protection scope of the present invention.Every impartial change done according to present invention and modification, be encompassed by the scope of the claims of the present invention.
Claims (4)
1. the kit of tyrosine phenol metabolism thing in detection human urine, in this detection human urine, the kit of tyrosine phenol metabolism thing includes phenol core developer and separates film, described separation film is the perforated membrane that aperture is less than 0.1 micron, and described separation film is 1:50-100 with the volume ratio of urine to be measured；
Described phenol core developer is containing mercury ion, the solution of mercurous ion；
Described perforated membrane is several layers, and described perforated membrane includes 100 weight portion polyolefin and 30-150 weight portion organic filler；
One or more in aluminum diethylphosphinate, trimethylethyl phosphinic acids aluminium, diphenyl phosphonic acid aluminium, diethyl phosphinic acids zinc, Methylethyl phosphinic acids zinc, diphenyl phosphonic acid zinc, diethyl phosphinic acids oxygen titanium, diethyl phosphinic acids titanium, Methylethyl phosphinic acids oxygen titanium, Methylethyl phosphinic acids titanium, diphenyl phosphonic acid oxygen titanium, diphenyl phosphonic acid titanium of described organic filler；
The particle diameter of described organic filler is 1-5000 nanometer；
Described polyolefinic fusion temperature is 130-150 degree Celsius, and described organic filler keeps solid-state when 130 degrees Celsius.
The kit of tyrosine phenol metabolism thing in detection human urine the most according to claim 1, it is characterised in that described polyolefin is polypropylene-based resin.
The kit of tyrosine phenol metabolism thing in detection human urine the most according to claim 2, it is characterised in that described polypropylene-based resin is at least one in the copolymer of polypropylene or propylene and other alkene.
4. urine detection method, comprises the following steps:
Urine is used the separation UF membrane described in any one in claim 1-3, obtains urine separation liquid,
Urine separation liquid is contacted with the phenol core developer described in any one in claim 1-3, it may be judged whether chromogenic reaction occurs.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107014806B (en) * | 2017-03-29 | 2019-05-31 | 汉宇集团股份有限公司 | A kind of Test paper of urine tyrosine |
| CN107084977B (en) * | 2017-04-26 | 2020-02-18 | 浙江欣叶健康管理有限公司 | Reagent for detecting tyrosine phenol metabolites in urine and product thereof |
| CN107064128B (en) * | 2017-04-26 | 2020-01-17 | 浙江欣叶健康管理有限公司 | Urine detection reagent and urine detection test paper prepared from same |
| CN108922630A (en) * | 2018-06-28 | 2018-11-30 | 上海森亿医疗科技有限公司 | A kind of method and device pushing knowledge |
| CN109115764B (en) * | 2018-07-30 | 2021-06-15 | 深圳瑞达生物股份有限公司 | Environment-friendly urine hydroxyphenyl derivative detection reagent and preparation method thereof |
| CN109470696A (en) * | 2018-12-27 | 2019-03-15 | 冀晓玲 | A kind of detection reagent and preparation method thereof of quick detection urine para hydroxybenzene alanine |
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