CN104922088A - Formula of hard empty capsule encapsulant - Google Patents
Formula of hard empty capsule encapsulant Download PDFInfo
- Publication number
- CN104922088A CN104922088A CN201510311313.3A CN201510311313A CN104922088A CN 104922088 A CN104922088 A CN 104922088A CN 201510311313 A CN201510311313 A CN 201510311313A CN 104922088 A CN104922088 A CN 104922088A
- Authority
- CN
- China
- Prior art keywords
- hollow
- hard capsule
- sealing compound
- coloring agent
- flocculation aid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a formula of a hard empty capsule encapsulant. The hard empty capsule encapsulant comprises 5-20 percent of medicinal coating material, 0-2 percent of a coloring agent, 1-5 percent of a coagulant aid, 10-20 percent of a drying-aid diluter and purified water in balancing amount. The problem that a hard empty capsule has poor leakproofness after being filled with solid and liquid inclusions is solved, a solution is provided for the problems that botanical inclusions can volatile easily and liquid inclusions can seep easily, and a preparation technology of the hard empty capsule encapsulant is provided.
Description
Technical field
The present invention relates to the sealing tech after all kinds of hollow and hard capsule-filling solid-liquid content, particularly relate to a kind of formula of hollow and hard capsule sealing compound.
Background technology
After traditional hollow and hard capsule-filling solid-liquid content, due to cap, body two saves suit place slight void, add Capsules On Anti oxidation in storage process poor, easily change, slight void between cap body can increase again, become seepage flow, " window " of volatilization, cause the active ingredient loss in various degree of content.Product curative effect lowers, thus has influence on product quality, and can not satisfy the demands of consumers, particularly the content of plant source class, abnormal smells from the patient itself is a kind of active ingredient.How to prevent plant source class content abnormal smells from the patient from volatilizing, it is a difficult problem for traditional plant source class content always, the requirement of plant source class content is met by the difficult problem solving the volatilization of plant source class content that hollow and hard capsule sealing compound is strong, ensure that product quality, as adjusted a little hollow and hard capsule sealing compound, also cause the sealing of acid resistance hollow and hard capsule.
The tradition painted aspect of hollow and hard capsule, due to the restriction of technique, every hollow and hard capsule color code can not surpass two, as needed marking to remember, one can be increased, after coating hollow and hard capsule sealing compound, hollow and hard capsule cap body suit place, increase a colored ribbon, not only meet the requirement of content, outward appearance becomes vivid easy difference.
Summary of the invention
The object of the present invention is to provide a kind of formula of hollow and hard capsule sealing compound, after solving hollow and hard capsule-filling solid-liquid content, sealing is not enough, fill up that to provide plant source class content abnormal smells from the patient volatile, liquid contents easy seepage flow difficult problem solution, provides hollow and hard capsule sealing compound preparation technology.
In order to achieve the above object, technical scheme of the present invention is:
A kind of hollow and hard capsule sealing compound, described sealing compound comprise for hollow and hard capsule sealing compound material of main part pharmaceutical coating material, coloring agent, flocculation aid, purify waste water, wherein pharmaceutical coating material 5-20%, coloring agent 0-2%, flocculation aid 1-5%, help and dryly release liquid 10-20%, all the other are for purifying waste water.
Described pharmaceutical coating material is pharmagel, hypromellose, pulullan polysaccharide, one or more of hydroxypropyl cellulose; Described coloring agent be natural class iron oxide red, iron oxide yellow, iron oxide brown, iron oxide black, synthesis class carmine, amaranth, lemon yellow, bright orchid one or more; Described flocculation aid be sodium alginate, carrageenan, agar, gellan gum, any one; Described helps dry liquid of releasing to be anhydrous alcohol for medical use or medicinal acetone.
A kind of preparation method of hollow and hard capsule sealing compound: 1. heat and dissolve, stirring of heating of purifying waste water, water temperature is added to 20-80 DEG C, adds pharmaceutical coating material, dissolves into pasty state; 2. auxiliary agent adds, and adds coloring agent and flocculation aid successively, wherein coloring agent 0-2%, flocculation aid 1-5%, continues to stir, and dissolves thoroughly; 3. viscosimetric analysis, after dissolving 60 points, gets sample 100cc constant temperature at 40 DEG C, measures, make it meet the requirements to viscosity, for subsequent use after filtering; 4. liquid is released in interpolation needs the used time, by hollow and hard capsule sealing compound for subsequent use, is warmed to 40 DEG C; 5. add helping of 10-20% and dryly release liquid, stir, static, special closing machine can be gone up and need use, be coated onto the suit place of hollow and hard capsule cap body, rapid draing, perfect molding.
The invention has the beneficial effects as follows: after the invention solves hollow and hard capsule-filling solid-liquid content, sealing is not enough, fill up that to provide plant source class content abnormal smells from the patient volatile, liquid contents easy seepage flow difficult problem solution, provides hollow and hard capsule sealing compound preparation technology.
Detailed description of the invention
Embodiment 1
A kind of hollow and hard capsule sealing compound, described sealing compound comprise for hollow and hard capsule sealing compound material of main part pharmaceutical coating material, coloring agent, flocculation aid, purify waste water, wherein pharmaceutical coating material 5-20%, coloring agent 0-2%, flocculation aid 1-5%, help and dryly release liquid 10-20%, all the other are for purifying waste water.
Described pharmaceutical coating material is pharmagel, hypromellose, pulullan polysaccharide, one or more of hydroxypropyl cellulose; Described coloring agent be natural class iron oxide red, iron oxide yellow, iron oxide brown, iron oxide black, synthesis class carmine, amaranth, lemon yellow, bright orchid one or more; Described flocculation aid be sodium alginate, carrageenan, agar, gellan gum, any one; Described helps dry liquid of releasing to be anhydrous alcohol for medical use or medicinal acetone.
A kind of preparation method of hollow and hard capsule sealing compound: 1. heat and dissolve, stirring of heating of purifying waste water, water temperature is added to 20-80 DEG C, adds pharmaceutical coating material, dissolves into pasty state; 2. auxiliary agent adds, and adds coloring agent and flocculation aid successively, wherein coloring agent 0-2%, flocculation aid 1-5%, continues to stir, and dissolves thoroughly; 3. viscosimetric analysis, after dissolving 60 points, gets sample 100cc constant temperature at 40 DEG C, measures, make it meet the requirements to viscosity, for subsequent use after filtering; 4. liquid is released in interpolation needs the used time, by hollow and hard capsule sealing compound for subsequent use, is warmed to 40 DEG C; 5. add helping of 10-20% and dryly release liquid, stir, static, special closing machine can be gone up and need use, be coated onto the suit place of hollow and hard capsule cap body, rapid draing, perfect molding.
The formula of a kind of hollow and hard capsule sealing compound of the present embodiment, after solving hollow and hard capsule-filling solid-liquid content, sealing is not enough, fill up that to provide plant source class content abnormal smells from the patient volatile, liquid contents easy seepage flow difficult problem solution, provides hollow and hard capsule sealing compound preparation technology.
Claims (3)
1. a hollow and hard capsule sealing compound, it is characterized in that: described sealing compound comprise for hollow and hard capsule sealing compound material of main part pharmaceutical coating material, coloring agent, flocculation aid, purify waste water, wherein pharmaceutical coating material 5-20%, coloring agent 0-2%, flocculation aid 1-5%, help and dryly release liquid 10-20%, all the other are for purifying waste water.
2. a kind of hollow and hard capsule sealing compound according to claim 1, is characterized in that: described pharmaceutical coating material is pharmagel, hypromellose, pulullan polysaccharide, one or more of hydroxypropyl cellulose; Described coloring agent be natural class iron oxide red, iron oxide yellow, iron oxide brown, iron oxide black, synthesis class carmine, amaranth, lemon yellow, bright orchid one or more; Described flocculation aid be sodium alginate, carrageenan, agar, gellan gum, any one; Described helps dry liquid of releasing to be anhydrous alcohol for medical use or medicinal acetone.
3. a preparation method for hollow and hard capsule sealing compound, is characterized in that, 1. comprising the steps: heats dissolves, stirring of heating of purifying waste water, and water temperature is added to 20-80 DEG C, adds pharmaceutical coating material, dissolves into pasty state; 2. auxiliary agent adds, and adds coloring agent and flocculation aid successively, wherein coloring agent 0-2%, flocculation aid 1-5%, continues to stir, and dissolves thoroughly; 3. viscosimetric analysis, after dissolving 60 points, gets sample 100cc constant temperature at 40 DEG C, measures, make it meet the requirements to viscosity, for subsequent use after filtering; 4. liquid is released in interpolation needs the used time, by hollow and hard capsule sealing compound for subsequent use, is warmed to 40 DEG C; 5. add helping of 10-20% and dryly release liquid, stir, static, special closing machine can be gone up and need use, be coated onto the suit place of hollow and hard capsule cap body, rapid draing, perfect molding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510311313.3A CN104922088A (en) | 2015-06-09 | 2015-06-09 | Formula of hard empty capsule encapsulant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510311313.3A CN104922088A (en) | 2015-06-09 | 2015-06-09 | Formula of hard empty capsule encapsulant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104922088A true CN104922088A (en) | 2015-09-23 |
Family
ID=54109750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510311313.3A Pending CN104922088A (en) | 2015-06-09 | 2015-06-09 | Formula of hard empty capsule encapsulant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104922088A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940161A (en) * | 2015-06-10 | 2015-09-30 | 绍兴康可胶囊有限公司 | Preparation method of sealing compound for hard hollow capsules |
| TWI612976B (en) * | 2015-11-04 | 2018-02-01 | Garry Tsaur | Capsule sealing composition and storage method thereof |
| CN107823175A (en) * | 2017-12-08 | 2018-03-23 | 江苏力凡胶囊有限公司 | A kind of Capsules modified hydroxypropyl methyl cellulose sealing compound and preparation method thereof |
| CN108096210A (en) * | 2017-12-08 | 2018-06-01 | 江苏力凡胶囊有限公司 | A kind of interior Capsules gelatin sealing compound for containing plant source content |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA669954A (en) * | 1963-09-03 | A. Roed Henrik | Method for the sealing of gelatin capsules | |
| EP0210325B1 (en) * | 1985-07-30 | 1991-02-06 | Shinjiro Tsuji | Method of film-coating hard capsules |
| CN1343488A (en) * | 2000-09-15 | 2002-04-10 | 付俊昌 | Capsule and its preparing process and application |
| CN1440740A (en) * | 2002-02-26 | 2003-09-10 | 潮州市药用胶囊厂 | New technology for filling soft preparation into hard capsule |
-
2015
- 2015-06-09 CN CN201510311313.3A patent/CN104922088A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA669954A (en) * | 1963-09-03 | A. Roed Henrik | Method for the sealing of gelatin capsules | |
| EP0210325B1 (en) * | 1985-07-30 | 1991-02-06 | Shinjiro Tsuji | Method of film-coating hard capsules |
| CN1343488A (en) * | 2000-09-15 | 2002-04-10 | 付俊昌 | Capsule and its preparing process and application |
| CN1440740A (en) * | 2002-02-26 | 2003-09-10 | 潮州市药用胶囊厂 | New technology for filling soft preparation into hard capsule |
Non-Patent Citations (3)
| Title |
|---|
| 朱照静，主编: "《药剂学》", 30 June 2010, 科学出版社 * |
| 王春龙，等: "硬胶囊封口技术的应用", 《中草药》 * |
| 许锐鹏，等: "硬胶囊剂封口技术的应用", 《机电信息》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940161A (en) * | 2015-06-10 | 2015-09-30 | 绍兴康可胶囊有限公司 | Preparation method of sealing compound for hard hollow capsules |
| TWI612976B (en) * | 2015-11-04 | 2018-02-01 | Garry Tsaur | Capsule sealing composition and storage method thereof |
| CN107823175A (en) * | 2017-12-08 | 2018-03-23 | 江苏力凡胶囊有限公司 | A kind of Capsules modified hydroxypropyl methyl cellulose sealing compound and preparation method thereof |
| CN108096210A (en) * | 2017-12-08 | 2018-06-01 | 江苏力凡胶囊有限公司 | A kind of interior Capsules gelatin sealing compound for containing plant source content |
| CN108096210B (en) * | 2017-12-08 | 2020-05-12 | 江苏力凡胶囊有限公司 | Gelatin sealing glue for empty capsules containing plant source contents |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2667167C (en) | Hydroxypropyl methyl cellulose hard capsules and process of manufacture | |
| CN103301086B (en) | Plant cellulose hard empty capsule preparation method | |
| CN104922088A (en) | Formula of hard empty capsule encapsulant | |
| CN104940161A (en) | Preparation method of sealing compound for hard hollow capsules | |
| CN104886554B (en) | Quick-fried pearl soft capsule and preparation method thereof | |
| CN104398488B (en) | A kind of Chinese yam starch capsule shells and preparation method thereof containing ginger essential oil | |
| CN103330695B (en) | Preparation method for enteric plant cellulose hard hollow capsules | |
| CN103432096B (en) | Hydroxypropyl methylcellulose enteric empty capsule jellied by carrageenan and potassium citrate | |
| CN105878209A (en) | Plant protein empty capsule and preparation method thereof | |
| CN103656655B (en) | A kind of Capsules and preparation method thereof | |
| CN104840447A (en) | Preparation method of pulullan vacant capsules | |
| CN103800303A (en) | Enteric gelatin hollow capsule and preparation method thereof | |
| CN104939300A (en) | Preparation method for stored water or water solution dewatering composite capsule for cigarettes | |
| CN103203042A (en) | Water-soluble medical lubricant | |
| CN104042589A (en) | Capsule without animal proteins and preparation method thereof | |
| CN103055317A (en) | Instant plant soft capsule and preparation method thereof | |
| CN103211782A (en) | Empty capsule suitable for being filled with traditional Chinese medicines | |
| EP3881834A1 (en) | Pullulan empty hard capsule and preparation method therefor | |
| CN102743359A (en) | Cellulose or polysaccharide plant pearly-luster hollow capsule and method for preparing same | |
| CN103417511B (en) | Hypromellose enteric empty capsule gelated by gellan gum and calcium chloride | |
| CN103417978B (en) | Hypromellose enteric empty capsule gelated by gellan gum and potassium citrate | |
| CN103301087A (en) | Production process of enteric gelatin hollow capsules | |
| CN106336525B (en) | Plant hollow capsule tailing redissolution method | |
| CN103340838A (en) | Enteric gelatin hollow capsule | |
| CN107823175B (en) | Modified hydroxypropyl methyl cellulose sealing adhesive for hollow capsules and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150923 |
|
| WD01 | Invention patent application deemed withdrawn after publication |