CN104921760B - The device and application method of Collection and conservation body fluid - Google Patents
The device and application method of Collection and conservation body fluid Download PDFInfo
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- CN104921760B CN104921760B CN201510408631.1A CN201510408631A CN104921760B CN 104921760 B CN104921760 B CN 104921760B CN 201510408631 A CN201510408631 A CN 201510408631A CN 104921760 B CN104921760 B CN 104921760B
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Abstract
The invention provides a kind of device of Collection and conservation body fluid and application method, the device includes storage body, and liquid and body fluid are preserved for storing；One plug, for blocking the storage body；Also include a sealing device, including the seal pipe and annular seal being arranged in the storage body；The storage body is divided into first annular seal space body and the second seal cavity by the annular seal；The seal pipe activity, which is plugged in the annular seal, to be turned on the first annular seal space body and second seal cavity or seals off.The present invention is collected the method for preserving body fluid using the device, can reduce operating procedure, improves the experience sense of user, and then is able to ensure that the quality for collecting body fluid, improves the accuracy rate examined.
Description
Technical field
The present invention relates to the device and method of Collection and conservation body fluid, espespecially a kind of collect being capable of long term sealed save after body fluid
Device and application method.
Background technology
With the development that individual human genome is detected, convenient and swift efficiently collection human DNA turns into a kind of demand, from collection
DNA is extracted in the body fluid arrived, such as saliva, blood, and conventional unsuitable human genome of the method drawn blood detects market, because
This extracts DNA from saliva turns into a kind of simple, easily method.
It is few on preserving the product of saliva in the market, two classes are broadly divided into, one kind is by funnel, saliva collection pipe
Deposited with 2-3 independent part is divided into equipped with the pipe for preserving liquid, user has told to be required to will be equipped with preserving liquid after saliva
Preservation liquid in pipe is poured into saliva collection pipe, and funnel is then backed out again, covers special lid.Specific operating procedure
Preserve liquid lid-preservation liquid is poured into from funnel-tell-to back out and back out funnel-cover the step of special lid etc. at least five
Suddenly.And some product funnels are separately provided, required step is more cumbersome, and Consumer's Experience is not good.
Although another kind of product will preserve liquid in design and funnel unites two into one, it will be set after having part user collection
Have after the lid for preserving liquid combined with funnel, take for having completed sampling, (cover seem after funnel saliva collection pipe be by
Sealedly, but sealing is practically without, the sample of collection is easily revealed in transportation).Therefore, when necessary after the completion of collection
Carve and remind user to back out funnel, then cover special lid, be so likely to result in fractional-sample failure, operation cost is improved,
Outflow is just mixed with the saliva of collection after preservation liquid must be punctured by external force in operating process simultaneously, the step of whole operation process
Suddenly funnel-cover four steps such as special lid still are backed out to tell-flowing out preservation liquid-, operated still cumbersome.
Thus, how to simplify operating procedure effectively preserves sampling, is the problem of those skilled in the art need solution.
The content of the invention
It is an object of the present invention to provide a kind of device of rear Collection and conservation body fluid and application method, body fluid can be simplified
The step of sampling, and do not result in failure after sampling.
The technical scheme that the present invention is provided is as follows：
A kind of device of Collection and conservation body fluid, including：
One storage body, liquid and body fluid are preserved for storing；
One plug, for blocking the storage body；
Also include a sealing device, including the seal pipe and annular seal being arranged in the storage body；
The storage body is divided into first annular seal space body and the second seal cavity by the annular seal；
The seal pipe activity is plugged in the first annular seal space body and the described second sealing in the annular seal
Cavity is turned on or sealed off.
The technical program, sets sealing device in storage, passes through the sealing being made up of seal pipe and annular seal in vivo
The problem of device not only solves preservation liquid sealing preserve, while can simplify the step of humor collecting and preservation, and ensures
The sample quality of collection.The structure is not only simple, with low cost, and user's experience effect is preferable.
It is preferred that the annular seal is provided with a jack；
The seal pipe is provided with perforate provided with an openend and a socket end, the socket end；
When the socket end of the seal pipe is plugged in the jack, the first annular seal space body and second annular seal space
Body is sealed off；
When the socket end of the seal pipe departs from the jack, the first annular seal space body and second seal cavity
Conducting.
The technical program, is coordinated by the jack in the socket end and annular seal of seal pipe, can solve body
The problem of collection of liquid is with further being preserved, when socket end is inserted into jack, first annular seal space body and the second sealing
Cavity must be seal isolation, it is therefore an objective to ensure that storage body preserves liquid before being not used and will not be compromised.And it is close to work as first
Seal the conducting of cavity and the second seal cavity, in order to make the preservation in the body fluid and the second seal cavity collected in seal pipe
Liquid is mixed, and is preserved for a long time, improves the quality for collecting body fluid.
It is preferred that the jack is more than the aperture away from the socket end close to a perforate footpath of the socket end；
The socket end of the seal pipe matches with the jack close to the aperture of the socket end side.
Being matched socket end with jack close to the aperture of socket end side in the technical program, while jack is set
Aperture, it is therefore an objective to after ensureing in socket end insertion jack, improve both sealing, prevent from preserving liquid close from second
Seal in cavity and flow out.
It is preferred that openend flaring of the socket end of the seal pipe along the socket end is into radial；
Or；
Openend of the socket end of the seal pipe along the socket end is into a ladder.
The technical program solves body fluid when socket end departs from annular seal by the design of sealed tube wall shape and flowed out
The problem of, further improve the body fluid rate of outflow collected in socket end, it is ensured that the body fluid therein while seal pipe is removed
Therefrom flow completely out.
It is preferred that being provided inwardly with a projection in the socket end, the projection is raised towards the openend；
It is preferred that the perforate is trapezoidal or square, and it is arranged on the socket side wall of the seal pipe.
One projection is inwardly set in the technical program in socket end, and trapezoidal or square perforate is arranged on seal pipe
On the side wall of socket end, while the speed of body fluid outflow can be increased, it is to avoid produce liquid buildup in seal pipe socket end
In madial wall, and the utilization rate for collecting body fluid is improved, while global design is more attractive in appearance.
It is preferred that connecting a funnel in the seal pipe, junction is provided with limited block, and the limited block is used to limit described
The position of funnel movement.
The technical program preferably reconnects a funnel in seal pipe, is primarily to facilitate user and collects body fluid, to the greatest extent may be used
Can ground raising collection efficiency.And limited block is set on junction, mainly limit what seal pipe was moved down by limited block
Position, and then the position of fixed funnel.
It is preferred that the openend of the seal pipe is connected with the storage body.
The opening of seal pipe is connected by the technical program with storage body, can not only be ensured first before body fluid is not collected
Seal cavity is in sealing state, while annular seal and the sealing and bonding strength of seal pipe socket end can be ensured,
Prevent that both depart from transportation.
It is preferred that the plug is lid or plug.
Present invention also offers a kind of method of the device of use Collection and conservation body fluid, foregoing Collection and conservation body fluid is utilized
Device to humor collecting, and the method preserved comprises the following steps：
A) the storage body for being preinstalled with and preserving liquid, is taken out, body fluid is flowed into from funnel；
B) funnel, is backed out, body fluid flows into first annular seal space body from seal pipe, the second sealing is flowed into via annular seal
In cavity；
C), with plug closure storage body, sampling is completed.
It is sealed in advance in the second seal cavity it is preferred that preserving liquid before sampling；Body fluid is mixed with preserving liquid after sampling
It is stored in storage body.
The present invention is by adopting the above-described technical solution, according to this, with advantages below：Setting by sealing device of the invention
Put, realize the preservation to preserving liquid, and user only need to simply tell-back out funnel-close the lid these three steps
The sampling of body fluid is completed, is operated simpler；Wherein, the hopper design of open type allows user to be closed the lid after will not forgetting sampling.
The overall volume of the structure is smaller, and good sealing effect, is easy to long-term preservation.
Brief description of the drawings
Below by clearly understandable mode, preferred embodiment is described with reference to the drawings, to the device of Collection and conservation body fluid
Above-mentioned characteristic, technical characteristic, advantage and its implementation be further described.
Fig. 1 is that the device of the Collection and conservation body fluid of the present invention preserves status architecture schematic diagram；
Fig. 2 be the present invention Collection and conservation body fluid device collect before structural representation；
Fig. 3 be the present invention Collection and conservation body fluid device in store body schematic diagram；
Fig. 4 is the cross section view on Fig. 3 A-A directions；
Fig. 5 be the present invention Collection and conservation body fluid device in annular seal structural representation；
Fig. 6 be the present invention Collection and conservation body fluid device in seal pipe be connected with funnel after the first structural representation
Figure；
Fig. 7 is the sectional view on Fig. 6 B-B directions；
Fig. 8 be the present invention Collection and conservation body fluid device in seal pipe be connected with funnel after second of structure section
View, profile direction is identical with Fig. 7；
Fig. 9 be the present invention Collection and conservation body fluid device in funnel top view；
Figure 10 be the present invention Collection and conservation body fluid device in plug cut-away section structure chart.
Drawing reference numeral explanation：
1st, body is stored；
101st, inlet；1011st, internal thread；
102nd, boss；103rd, first annular seal space body；104th, the second seal cavity；
2nd, plug；
201st, the second external screw thread；202nd, groove；
3rd, sealing device
301st, seal pipe；3011st, openend；3012nd, socket end；3013rd, perforate；3014th, projection；311st, the first outer spiral shell
Line；
302nd, annular seal；3021st, jack；
4th, funnel；
401st, limited block.
Embodiment
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, control is illustrated below
The embodiment of the present invention.It should be evident that drawings in the following description are only some embodiments of the present invention, for
For those of ordinary skill in the art, on the premise of not paying creative work, other can also be obtained according to these accompanying drawings
Accompanying drawing, and obtain other embodiments.
To make only to schematically show part related to the present invention in simplified form, each figure, their not generations
Table its as product practical structures.In addition, so that simplified form is readily appreciated, there is identical structure or function in some figures
Part, only symbolically depict one of those, or only marked one of those.Herein, " one " not only table
Show " only this ", the situation of " more than one " can also be represented.
Reference picture 1, Fig. 2, have less part, with existing device in the device of the Collection and conservation body fluid of the present invention
Structure compared is simple, and operation simplifies, and user's experience is more.In addition, the device of Collection and conservation body fluid includes the storage He of body 1
Plug 2, while also include being provided with a funnel 4, and funnel 4 and seal pipe 301 are formed in one or detachably connected
Onto storage body 1, wherein, funnel 4 is the design of open type, is effectively prevented from forgetting to cover plug after user collects body fluid
2 carry out sealing preserve, and the plug 2 in the application can be lid or plug, need to only meet and be sealed in the body fluid of collection
Store in body 1, belong to protection domain.The device (is saliva in the application, or other people collecting body fluid
Body body fluid, such as urine) before, the seal pipe 301 that funnel 4 is connected is tightly connected with annular seal 302；After body fluid has been collected
Remove the body fluid in funnel 4, funnel 4 and can flow into annular seal 302 and mixed with the preservation liquid of advance sealing preserve, block closure
Thing 2.
In an embodiment of the present invention, referring to Fig. 1, the device of specific Collection and conservation body fluid, which includes one, to be used to store preservation
Liquid is stored on the plug 2 that body 1 and one is used to block storage body 1, storage body 1 with body fluid the inlet entered for body fluid
101, inlet 101 is to be detachably connected with plug 2, it is ensured that empty into a sealing in storage body 1 after plug 2 is blocked
Between.
Referring to Fig. 2,3,4, and then body 1 is stored before body fluid is collected, it is ensured that the preservation liquid in storage body 1 is constantly in close
Envelope state.Therefore, a sealing device 3 is set in storage body 1, sealing device 3 includes seal pipe 301 and annular seal
302, and store body 1 and the seal cavity 104 of first annular seal space body 103 and second, the second annular seal space are divided into by annular seal 302
Preservation liquid is prestored in body 104.Wherein seal pipe 301 is actively plugged in annular seal 302, realizes first annular seal space body
103 and second seal cavity 104 conducting or seal isolation, and then the body fluid of collection mix with preserving liquid, during extension preservation
Between.
In an embodiment of the present invention, because the body fluid collected in seal pipe 301 finally still will be with the second seal cavity
Preservation liquid mixing in 104.Referring to Fig. 5, a jack 3021 is opened up on annular seal 302.Referring to Fig. 6, seal pipe 301 is provided with
One openend 3011 and a socket end 3012, and provided with perforate 3013 in socket end 3012, and design the purpose of perforate 3013
It is the body fluid collected in seal pipe 301 is flowed out from perforate 3013.And then when seal pipe 301 socket end 3012 be plugged in it is slotting
In hole 3021, first annular seal space body 103 is sealed off with the second seal cavity 104；When the socket end 3012 of seal pipe 301 is with inserting
When hole 3021 departs from, first annular seal space body 103 is turned on the second seal cavity 104.According to this, the seal pipe before body fluid is collected
301 openend 3011 is connected with inlet 101, and socket end 3012 is inserted in jack 3021, can effectively ensure whole
The connective stability of individual sealing device 3 and storage body 1, prevents from preserving liquid leakage.
It is not leaked further to ensure that storage body 1 preserves liquid before the use, by jack 3021 close to socket end
What 3012 aperture was set is more than the aperture away from aperture socket end 3012, its hole wall is designed to inclined-plane.And then ensure socket
End 3012 matches close to the side of annular seal 302 with jack 3021 close to the aperture of the side of socket end 3012, works as sealing
When the socket end 3013 of pipe 301 is inserted in jack 3021, seal pipe 301 and annular seal and socket end 3012 more moves down
302 sealings are closer.
Further again by the outer peripheral face of annular seal 302 with the storage inwall of body 1 into being tightly connected.Wherein, ring-type
Seal 302 can be with preferred rubber plug or rubber seal, and purpose need to only reach the effect of blocking, and why select rubber
Glue material matter, is due to that quality of rubber materials can increase the surrounding of annular seal 302 with storing the interior wall of body 1 (typically using polychlorostyrene
Vinyl material is made) frictional force, can not only improve sealing, and can prevent annular seal 302 from moving down and reduce
The memory space of two seal cavities 3012., can be referring again to Fig. 3,4, in the inwall surrounding of storage body 1 in specific design
Set up a boss 102, the setting of boss 102 can further limit seal pipe 301 store moved down in body 1 when, by
In firmly excessive and cause annular seal 302 to move down.
In an embodiment of the present invention, the sealing to keeping liquid is realized by the sealing device 3 set in memory bank 1, together
When also needed after body fluid has been collected as early as possible by body fluid with preserve liquid mix.Therefore, referring again to Fig. 6, specific seal pipe 301 is wrapped
Openend 3011 and socket end 3012 are included, and the one end of socket end 3012 is connected with openend 3011, it is ensured that received in openend 3011
The body fluid of collection can be flowed directly into socket end 3012, and the other end is necessary for closing, and why being closed not only prevents body fluid
Flowed directly into from socket end 3012 with keeping liquid to mix in second seal cavity 104, while ensureing that it is being not used in storage body 1
Between before the socket end 3012 of seal pipe 301 to be inserted in contact portion when in annular seal 302 close by ring-type by enclosed construction
The jack 3021 set on sealing 302 is blocked, it is therefore an objective to even if openend 3011 is unimpeded before ensureing to be not used
Under state, it is always to be sealingly retained in the second seal cavity 104 to preserve liquid.
It should illustrate, in order that the body fluid collected in seal pipe 301 quickly flows out, by the side of above-mentioned socket end 3012
Wall is arranged to an inclined plane, and (face close to the side of annular seal 302) is inwardly set on the sealing surface of socket end 3012
A projection 3014 is put, referring to Fig. 8, specifically design is socket end 3012 along one end flaring of openend 3011 into one to a kind of inclined plane
It is radial, while one arc-shaped of formation of projection 3014, and protruded towards openend 3011.Referring to Fig. 7, another inclination mask body
Design be that socket end 3012 is set into a ladder along the end of openend 3011, while one triangle of formation of projection 3014, and triangle
The peak of shape is towards openend 3011.The speed of outflow can not only so be increased, while the problem of avoiding not flowing to end.And have
Body structure setting can have more actual demand and do rational adjustment, belong within the scope of protection of the invention.
In an embodiment of the present invention, so could be effectively because the body fluid of collection still will finally be mixed with preserving liquid
Ground preserves the bodily fluid sampling of collection for a long time.So perforate 3013 is arranged on the side wall of socket end 3012 in the application, and set
For several, (quantity of perforate can be set the quantity put according to the outer peripheral face size of actual socket end 3012, and can uniformly or not
It is distributed), while the speed flowed out for guarantee body fluid from socket end 3012, is further set perforate 3013 in echelon
Or it is square, the application is preferably trapezoidal, and side width of the specific perforate mode close to openend 3011 is set greater than close to slotting
The side width at mouth end 3012.It is according to this, different according to socket end 3012 because the side wall of above-mentioned socket end 3012 is into an inclined plane
Pore size on cross section sets perforate 3013, can further improve the speed of body fluid outflow.
In an embodiment of the present invention, seal pipe 301 can not only realize sealing, while can also be by body fluid from seal pipe
Flowed into 301 openend 3011.Referring to Fig. 6,7,8,9, and then for convenience of collection liquid specifically in the opening of seal pipe 301
End 3011 connects a funnel 4, and limited block 401 is set on the outer wall of funnel 4 Yu the junction of seal pipe 301, and limited block 401
Can be set on whole outer wall, can also be set in a portion of outer wall.Purpose is limited by limited block 401
Determine the position that funnel 4 is moved when seal pipe 301 is moved down.Wherein, preferably funnel 4 and seal pipe 301 are integrally formed, funnels 4
It is that the openend 3011 of seal pipe 301 stretches out setting, while limited block 401 is set on the outer wall of extended spot, by spacing
Block 401 limits the shift position of funnel 4, and ensures the connective stability with storage body 1.The upper port of funnel 4 can be set simultaneously
Ellipse is set to, not only facilitates and collects body fluid, while improving the comfort level of user.
In an embodiment of the present invention, no matter being preserved before body fluid is collected or after collecting body fluid, it is both needed to ensure fortune
The problem of will not occurring liquid leakage during defeated.Ensure that preserving liquid does not leak before the storage use of body 1.Need further
The inwall for the inlet 101 that ground is opened up in storage body 1 upper end is provided with internal thread 1011, and outside the openend 3011 of seal pipe 301
First external screw thread 311 is set on wall, both stable connections can be ensured by the first external screw thread 311 and the connection of internal thread 1011
Property, while ensureing that seal pipe 301 and annular seal 302 are in sealing state.Referring to Figure 10, after body 1 is stored by use, lead to
Cross and the second external screw thread 201 is set on the lower end outer surface of plug 2 in advance, and then by the second external screw thread 201 and internal thread
After 1011 are spirally connected, long term seal holding can be carried out to sampling, while plug 2 of taking for convenience, further in plug 2
Upper end outer surface on several grooves 202 are set, and the shape of groove 202 can have certain rule or irregular
.It should illustrate, open up exiting for the rear mold of internal thread 1011 for convenience of in the inwall of inlet 101, and further protect
To preferably internal thread be provided with by demonstrate,proving in seal pipe 301 and the bonding strength of storage body 1, the present invention at the inlet 101 for storing body 1
What 1011 part apertures were set is more than remainder, can specifically adjust according to the actual requirements.
The present invention uses the procedure of the device of Collection and conservation body fluid：
In the present invention, it is specific a), take out equipped with preserve liquid storage body 1, spit into saliva in funnel 4；
B) funnel 4, is backed out, saliva is flowed into socket end 3012 from the openend 3011 of seal pipe 301, finally from socket end
Flowed out in the perforate 3013 opened up on 3012, second of the inflow storage body 1 of jack 3021 on by annular seal 302 is close
With keeping liquid to mix in envelope cavity 104.C), after funnel 4 is backed out completely, then plug 2 is screwed on, user just completes body fluid
Sampling.And preserve liquid before sampling and be sealed in the second seal cavity 104；Body fluid mixes preservation with preserving liquid after sampling
In storage body.Wherein, preserving the amount of liquid or the amount of mixed liquor after sampling can be obtained by the scale set on storage body 1
Know, thus storage body 1 can be arranged to partially transparent or all transparent, need to only ensure from the external energy of memory bank 1 it is directly perceived to
Amount of liquid.
It should be noted that above-described embodiment can independent assortment as needed.Described above is only the preferred of the present invention
Embodiment, it is noted that for those skilled in the art, is not departing from the premise of the principle of the invention
Under, some improvements and modifications can also be made, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of device of Collection and conservation body fluid, including：
One storage body, liquid and body fluid are preserved for storing；
One plug, for blocking the storage body；
It is characterised by, in addition to：
One sealing device, including the seal pipe and annular seal being arranged in the storage body；
The storage body is divided into first annular seal space body and the second seal cavity by the annular seal；
The annular seal is provided with a jack；
The seal pipe is provided with perforate provided with an openend and a socket end, the socket end；
When the socket end of the seal pipe is plugged in the jack, the first annular seal space body and second seal cavity are close
Insulate from；
When the socket end of the seal pipe departs from the jack, the first annular seal space body is led with second seal cavity
It is logical.
2. the device of Collection and conservation body fluid according to claim 1, it is characterised in that：
The jack is more than the aperture away from the socket end close to what the aperture of the socket end was set；
The socket end of the seal pipe matches with the jack close to the aperture of the socket end side.
3. the device of Collection and conservation body fluid according to claim 1, it is characterised in that：
Openend flaring of the socket end of the seal pipe along the socket end is into radial；
Or；
Openend of the socket end of the seal pipe along the socket end is into a ladder.
4. the device of Collection and conservation body fluid according to claim 1, it is characterised in that：
The socket end is provided with a projection, and the projection is raised towards the openend；
And/or；
The perforate is trapezoidal or square, and is arranged on the socket side wall of the seal pipe.
5. the device of Collection and conservation body fluid according to claim 1, it is characterised in that：
A funnel is also connected with the seal pipe, and junction is provided with limited block, the limited block is used to limit the funnel shifter
Dynamic position.
6. the device of Collection and conservation body fluid according to claim 1, it is characterised in that：
The openend of the seal pipe is connected with the storage body.
7. the device of Collection and conservation body fluid according to claim 1, it is characterised in that：
The plug is lid or plug.
8. a kind of method of the device of use Collection and conservation body fluid, it is characterised in that using as described in claim any one of 1-7
Collection and conservation body fluid device, it comprises the following steps：
A) the storage body for being preinstalled with and preserving liquid, is taken out, body fluid is flowed into from funnel；
B) funnel, is backed out, body fluid flows into first annular seal space body from seal pipe, the second seal cavity is flowed into via annular seal
In；
C), with plug closure storage body, sampling is completed.
9. the method for the device of use Collection and conservation body fluid according to claim 8, it is characterised in that：
Liquid is preserved before sampling to be sealed in advance in the second seal cavity；Body fluid mixes with preservation liquid and is stored in storage body after sampling
In.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510408631.1A CN104921760B (en) | 2015-07-13 | 2015-07-13 | The device and application method of Collection and conservation body fluid |
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| CN201510408631.1A CN104921760B (en) | 2015-07-13 | 2015-07-13 | The device and application method of Collection and conservation body fluid |
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| CN104921760A CN104921760A (en) | 2015-09-23 |
| CN104921760B true CN104921760B (en) | 2017-09-12 |
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| EP3549530A4 (en) * | 2016-11-30 | 2019-11-27 | Xiamen Zeesan Biotech Co., Ltd. | Device and method for collecting body fluid |
| CN106644602A (en) * | 2017-01-18 | 2017-05-10 | 广州新诚生物科技有限公司 | Integrated saliva collector |
| CN109738237B (en) * | 2019-03-18 | 2024-03-26 | 领因生物科技(上海)有限公司 | Liquid collecting device |
| CN109730727B (en) * | 2019-03-18 | 2024-05-24 | 领因生物科技(上海)有限公司 | Partition Collector |
| CN110074822A (en) * | 2019-05-29 | 2019-08-02 | 南通伊仕生物技术股份有限公司 | A kind of saliva collecting device |
| CN112472140A (en) * | 2020-05-11 | 2021-03-12 | 中山大学达安基因股份有限公司 | Storage tube for sampling swab |
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| CN202277840U (en) * | 2011-10-26 | 2012-06-20 | 米红 | Test tube |
| CN202355427U (en) * | 2011-11-14 | 2012-08-01 | 湖北维达健基因技术有限公司 | Saliva dna sample collector |
| CN204813975U (en) * | 2015-07-13 | 2015-12-02 | 上海慧晨生物医学科技有限公司 | Collect device of preserving body fluid |
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