CN104921724A - Gastric emptying simulator for electrical impedance imaging detection - Google Patents
Gastric emptying simulator for electrical impedance imaging detection Download PDFInfo
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- CN104921724A CN104921724A CN201510422686.8A CN201510422686A CN104921724A CN 104921724 A CN104921724 A CN 104921724A CN 201510422686 A CN201510422686 A CN 201510422686A CN 104921724 A CN104921724 A CN 104921724A
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- gastric emptying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0536—Impedance imaging, e.g. by tomography
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Abstract
The invention discloses a gastric emptying simulator for electrical impedance imaging detection. The gastric emptying simulator comprises a saline water tank, an annular electrode band, a support, a motor system, a transmission system, a lead screw, a stomach model and an electrical impedance imaging system. The saline water tank is an organic glass cylindrical bucket. The annular electrode band is composed of sixteen manganese-titanium electrode slices evenly distributed on the inner wall of the middle of the saline water tank, and the electrode slices are fixed to the inner wall of the saline water tank through stainless steel screws and connected with the electrical impedance imaging system through wires. The horizontal support is fixed to the side wall of the top of the saline water tank through screws and used for containing the motor system and the transmission system. The motor system drives the transmission system through a belt to make the lead screw rotate automatically and move vertically. The stomach model is fixed to the bottom of the lead screw, the lead screw drives the stomach model to move to simulate the shrinkage wriggle and gastric emptying processes of the stomach, the electrical resistance imaging system acquires information and reconstructs images through the annular electrode band, and the gastric emptying time is calculated according to the image result.
Description
Technical field
The present invention relates to biomedical signals measuring field, be mainly used in simulation gastric emptying process, and record this process by the mode of electrical impedance imaging, calculate the gastric emptying time according to image result.
Background technology
Gastric emptying crosses that to relax that gastric emptying overruns be the main manifestations of gastric motility exception.All there is gastric emptying exception in various degree in many common digestive tract power diseases clinically.Specify the relation between gastric motility disorder symptom, inspection performance, pathophysiological mechanism, Therapeutic selection, be the direction that gastroenterology expert makes great efforts always.Abnormal for various types of gastric motility, although gastric emptying value can only be pointed out, and certain disease can not be diagnosed, but after the organic reason of eliminating, the relation specifying external symptom and inherent gastric motility exception is carried out Diagnosis and Treat be very helpful to clinical success.
Much research all shows, the patients with functional dyspepsia of nearly half exists delayed gastric emptying.For dyspepsia, because the patient of delayed gastric emptying is obviously better than the normal patient of gastric emptying to the therapeutic response of medicine for stomach dynamic, so gastric emptying value has certain treatment guidance and the value of Index for diagnosis.
Stomach-esophageal reflux disease is often relevant with whole upper gastrointestinal power abnormality, and therefore understanding gastric emptying situation all can be helpful to the selection of the Diagnosis and Treat of the cause of disease.
Gastroparesis syndrome is called for short gastroparesis, take delayed gastric emptying as the syndrome of feature, main manifestations has early full, Abdeminal pain, Nausea and vomiting after the meal clinically, severe patient can have weight loss, and gastroscope, gastrointestinal series, Abdominal B type ultrasonography etc. check the organic disease without upper gastrointestinal mechanical obstruction and liver and gall.Gastroparesis is generally used for the state describing the delay of gastric emptying extreme.Gastroparesis can be divided into idiopathic and Secondary cases two kinds, and idiopathic gastroparesis reason is unclear, and causes the reason of Secondary cases gastroparesis a lot, common as diabetes etc.The diabetics of a large amount of foreign data display 50%-76% has delayed gastric emptying, therefore, understands and grasp gastric emptying situation in time, Diagnosis and Treat diabetic gastroparesis, will contribute to the control of blood glucose.
Another important application of stomach discharging test is the power change that detection esophagus stomach function regulating is performed the operation forward and backward.Perform the operation irreversible often, therefore operation consent understanding gastric emptying is sometimes very important, can help establish diagnosis and select rational modus operandi.Postsurgery symptoms may be speeded by gastric emptying or delay to cause, and in order to formulate further therapeutic scheme, understanding gastric emptying situation and having decisive significance.
The development of gastric motility medicine also promotes the clinical demand of stomach discharging test.The medicine for stomach dynamic of existing many different mechanisms is available clinically, is judging that in their curative effect, stomach discharging test has more advantage, can assist to find the medicine of better treatment gastric motility exception.
Current clinical conventional stomach discharging test method is nuclide gastric emptying assay method, the method is with in standard test-meal by the mixing of the medicine of radioisotope labeling, carry out chronophotograph through gamma camera in gastric area after oral, evaluate the time of gastric emptying according to the amount of gastric food radionuclide.Due to the stable chemical performance of radionuclide used at present, and not by gastrointestinal absorption, the motor process of gastric and the motor process of food completely the same, be therefore considered to gastric emptying measure goldstandard.But the method has certain radioactivity, be not suitable for anemia of pregnant woman and infant, and equipment costly, need a set of special technical staff.
The not saturating X-ray mark method Examined effect of gastric emptying, by regularly taking the photograph sheet after one or more saturating X-ray marks oral, the amount calculating stomach discharge mark estimates the speed of gastric emptying.X-ray mark method method is not simple thoroughly, and instrument requirements is not high, as long as can take plain abdominal radiograph, all can carry out this and check.But the not saturating inadequate physiology of X-ray mark inspection, as mark and food can not mix completely, can affect check result.
Ultrasonic examination can know the Potamogeton crispus of display gastric antrum, and gastral cavity is with or without abnormal dilatation and narrow.Can be observed stomach contraction, diastole, coat of the stomach wriggling, liquid by situations such as pyloruses by real-time ultrasound, observation gastric emptying and radionuclide imaging method have good dependency.But ultrasonic examination will be used for the long-time inspection of digestion process, also there is many difficulties in operating technology, and be only limitted to measure emptying rate of liquid, be not suitable for measuring solid emptying, because can testing result be affected when intracavity gas is more.
Desirable stomach discharging test method should have following characteristics: accurate, economic, reproducible, easy operation, Noninvasive, radiationless effect, liquid solid food are all applicable.
Electrical impedance imaging (electrical impedance tomography, hereinafter referred to as EIT) with the electrical impedance characteristics of tissue, organ and be changed to foundation, by being configured at the electrod-array of body surface, extract the tissue relevant to Human Physiology, pathological state or the electrical characteristics information of organ, provide the functional image result of response organization, organ dysfunction state and Changing Pattern thereof, its main advantage is to realize not damaged functional imaging and image monitoring, can the volume situation of change of body of stomach in the direct display body of mode of real time imaging.There is accurate, economic, reproducible, easy operation, feature that Noninvasive, radiationless effect, liquid solid food are all suitable for, be very applicable to stomach discharging test.At present, electrical impedance imaging is adopted to carry out the clinical application research of stomach discharging test also seldom, mainly owing to still lacking relevant applied basic research, food enters stomach from esophagus and enters duodenal process is a complicated evacuation procedure digested and assimilated, by the kind of food, the electric conductivity of food, the volume size of stomach, the electric conductivity of stomach self, the secretion of gastric acid, and the impact of other digestive organs, in order to promote the clinical practice of electrical impedance imaging stomach discharging test as early as possible, needs carry out necessary theoretical basis and experimental model is studied, relation between qualitative, quantitative research electrical impedance imaging result and gastric emptying, therefore the gastric emptying analog being specifically designed to electrical impedance imaging detection is needed.
Summary of the invention
For prior art, the present invention proposes a kind of gastric emptying analog detected for electrical impedance imaging, the correlative factor can simulated gastric emptying process and affect gastric emptying detects for electrical impedance imaging, realizes the relation between qualitative, quantitative research electrical impedance imaging result and gastric emptying.
In order to solve the problems of the technologies described above, a kind of gastric emptying analog detected for electrical impedance imaging that the present invention proposes, comprise electric impedance imaging system and a barrel-shaped saline slot, saline is filled with in described saline slot, the circumference of the middle part inwall of described saline slot is fixed with a ring electrode band, described ring electrode band is made up of equally distributed multiple manganese-titanium electrode slice, each manganese-titanium electrode slice is all adopted and is screwed, and each screw is drawn respectively the wire being connected to electric impedance imaging system input; The top of described saline slot is provided with a support, described support is fixed with electric system, described electric system drives a leading screw to move up and down vertically while carrying out rotation by a drive system, the bottom of described leading screw extend in the saline of described saline slot, and the bottom of described leading screw is fixed with a dielectric resilience solid cylindrical columns shape medium; The electrical conductivity of described dielectric resilience solid cylindrical columns shape medium is different from the conductivity of described saline.
Further, the internal diameter of described saline slot be 25cm, high for 30cm, wall thickness be the lucite drum of 0.6cm.
The quantity of manganese-titanium electrode slice is 8 or 16 or 32, the height of manganese-titanium electrode slice be 2cm, wide for 1.5cm, thick be 0.1cm.
Compared with prior art, the invention has the beneficial effects as follows:
The invention has the beneficial effects as follows and provide a kind of simple, convenient and the analog of practicality simulation food enters stomach from esophagus, and emptying process is used for electrical impedance imaging detects, simulate the impact of different factors on electrical impedance imaging stomach discharging test result.For electrical impedance imaging stomach discharging test provides necessary theoretical basis research, promote the development of electrical impedance imaging stomach discharging test clinical practice, for clinical stomach and intestine dynamics research provides a kind of new detection method to establish necessary theoretical basis and data.
Accompanying drawing explanation
Fig. 1 is used for the gastric emptying analog structure chart that electrical impedance imaging detects;
Fig. 2-1 to Fig. 2-6 is the images using analog gastric emptying process of the present invention, and wherein, Fig. 2-1 is initial pictures, Fig. 2-2 is images after 10 seconds, and Fig. 2-3 is images after 20 seconds, and Fig. 2-4 is images after 30 seconds, Fig. 2-5 is images after 40 seconds, and Fig. 2-6 is images after 50 seconds.
Detailed description of the invention
Be described in further detail technical solution of the present invention below in conjunction with the drawings and specific embodiments, described specific embodiment only explains the present invention, not in order to limit the present invention.
As shown in Figure 1, a kind of gastric emptying analog detected for electrical impedance imaging that the present invention proposes, comprise electric impedance imaging system 8 and a barrel-shaped saline slot 1, the lucite drum that the internal diameter of described saline slot 1 is 25cm, height is 30cm, wall thickness is 0.6cm, be filled with saline in described saline slot 1, described saline slot 1 is for simulating trunk position; The circumference of the middle part inwall of described saline slot 1 is fixed with a ring electrode band 2, described ring electrode band 2 is made up of uniform multiple manganese-titanium electrode slices, the quantity of manganese-titanium electrode slice is 8 or 16 or 32, be preferably 16, the height of manganese-titanium electrode slice be 2cm, wide for 1.5cm, thick be 0.1cm.Each manganese-titanium electrode slice is all adopted and is screwed, and each screw is drawn respectively the wire being connected to electric impedance imaging system 8 input, the top of described saline slot 1 is provided with a support 3, described support 3 be a pmma material make long 25.6cm, wide 10cm, high 10cm, wall thickness 1.5cm stool support, and by screw, the lower limb of this support 3 being fixed on the outer wall of saline slot 1, this support 3 is for placing electric system 4 and drive system 5, electric system 4 and drive system 5 are screwed on the surface plate of support 3, electric system 4 is by a DC brushless motor, belt pulley and electric machine controller composition, drive system 5 is made up of a gear and belt pulley, electric system 4 is connected by the belt be enclosed within two belt pulleys with drive system 5, DC brushless motor is rotated by belt drive gear while rotating, gear rotarily drives while screw mandrel 6 carries out rotation and moves up and down vertically, the bottom of described leading screw 6 extend in the saline of described saline slot 1, the bottom of described leading screw 6 is fixed with a dielectric resilience solid cylindrical columns shape medium 7, the electrical conductivity of described dielectric resilience solid cylindrical columns shape medium 7 is different from the conductivity of described saline, namely with the elastic solid medium of two kinds of different electrical conductivity and liquid medium simulation stomach and the tissue surrounding it, realize when changing arbitrary dielectric conductance rate simulating the impact of evacuation procedure, described dielectric resilience solid cylindrical columns shape medium 7 serves as stomach model and is synchronized with the movement with screw mandrel, while the motion of this stomach model, electric impedance imaging system gathers the anti-characteristic information of saline slot 1 boundary resistance by ring electrode band 2 and carries out reconstruction image, with certain output speed output image result, the time of gastric emptying can be calculated according to image result.
The process that the gastric emptying analog using the present invention to be used for electrical impedance imaging detection realizes gastric emptying simulation is: saline slot 1 simulates trunk position, the normal saline of certain conductivity is full of in saline slot 1, carry out simulated human tissue internal medium, serve as stomach model with a dielectric resilience solid cylindrical columns shape medium 7 and enter stomach thus the process that cause electrical characteristics change to the decline process simulation food progressively near ring electrode band 2 from esophagus from entering saline slot 1, stomach model (dielectric resilience solid cylindrical columns shape medium 7) progressively rise from ring electrode band 2 position and the process of the salt water surface of emersion saline slot 1 to simulate the evacuation procedure of stomach, electric impedance imaging system gathers impedance information by ring electrode band 2 and carries out image reconstruction, and record with certain output speed output image result the process that stomach model rises and decline in saline slot, the emptying time of stomach model just can be calculated according to image result.The testing result of electrical impedance imaging gastric emptying can according to the change of the electrical conductivity of normal saline, the change of the shape of stomach model, size, electrical conductivity and changing.
Experimental example: the normal saline electrical conductivity in saline slot 1 is set to 0.5S/m, stomach model is insulation solid cylindrical columns shape medium, stomach model progressively rises from ring electrode band 2 position and the evacuation procedure of emersion saline slot water simulation stomach, electric impedance imaging system gathers saline slot border electrical characteristics information by ring electrode band 2 and carries out image reconstruction, and with certain output speed output image result, stomach model progressively rises from ring electrode band 2 position and the set of time of the emersion saline slot water surface is 50 seconds, every 10 seconds records once, using initial time as the first sub-picture, totally 6 is secondary, as shown in Fig. 2-1 to 2-6, wherein, Fig. 2-1 to Fig. 2-6 is the images using analog gastric emptying process of the present invention, wherein, Fig. 2-1 is initial pictures, Fig. 2-2 is images after 10 seconds, Fig. 2-3 is images after 20 seconds, Fig. 2-4 is images after 30 seconds, Fig. 2-5 is images after 40 seconds, Fig. 2-6 is images after 50 seconds.Otherwise, the time of gastric emptying can be extrapolated according to the situation of image.
Although invention has been described by reference to the accompanying drawings above; but the present invention is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; instead of it is restrictive; those of ordinary skill in the art is under enlightenment of the present invention; when not departing from present inventive concept, can also make a lot of distortion, these all belong within protection of the present invention.
Claims (3)
1., for the gastric emptying analog that electrical impedance imaging detects, comprise electric impedance imaging system (8) and a barrel-shaped saline slot (1), described saline slot is filled with saline in (1), it is characterized in that:
The circumference of the middle part inwall of described saline slot (1) is fixed with a ring electrode band (2), described ring electrode band (2) is made up of equally distributed multiple manganese-titanium electrode slice, each manganese-titanium electrode slice is all adopted and is screwed, and each screw is drawn respectively the wire being connected to electric impedance imaging system (8) input;
The top of described saline slot (1) is provided with a support (3), described support (3) is fixed with electric system (4), described electric system (4) drives a leading screw (6) to move up and down vertically while carrying out rotation by a drive system (5), the bottom of described leading screw (6) extend in the saline of described saline slot (1), and the bottom of described leading screw (6) is fixed with dielectric resilience solid cylindrical columns shape medium (7); The electrical conductivity of described dielectric resilience solid cylindrical columns shape medium (7) is different from the conductivity of described saline.
2. a kind of gastric emptying analog detected for electrical impedance imaging according to claim 1, is characterized in that, the internal diameter of described saline slot (1) be 25cm, high for 30cm, wall thickness be the lucite drum of 0.6cm.
3. a kind of gastric emptying analog detected for electrical impedance imaging according to claim 1, it is characterized in that, the quantity of manganese-titanium electrode slice is 8 or 16 or 32, the height of manganese-titanium electrode slice be 2cm, wide for 1.5cm, thick be 0.1cm.
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-
2015
- 2015-07-17 CN CN201510422686.8A patent/CN104921724A/en active Pending
Patent Citations (9)
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| CN2065462U (en) * | 1989-10-30 | 1990-11-14 | 江西中医学院 | Impedance measuring device for gastric movement |
| US6360123B1 (en) * | 1999-08-24 | 2002-03-19 | Impulse Dynamics N.V. | Apparatus and method for determining a mechanical property of an organ or body cavity by impedance determination |
| CN1305777A (en) * | 2000-01-20 | 2001-08-01 | 深圳市辉大高科技发展有限公司 | Stomach power test method and tester based on said method |
| US20050090873A1 (en) * | 2003-10-22 | 2005-04-28 | Imran Mir A. | Gastrointestinal stimulation device |
| WO2008103077A1 (en) * | 2007-02-21 | 2008-08-28 | St. Jude Medical Ab | Detect eating to initiate gastric pacing |
| WO2009043168A1 (en) * | 2007-10-05 | 2009-04-09 | Uti Limited Partnership | Feedback controlled gastro-intestinal stimulation |
| CN201223391Y (en) * | 2008-04-15 | 2009-04-22 | 中国医学科学院生物医学工程研究所 | Electrode design for electric impedance tomography imaging simulated experiment device |
| CN102008304A (en) * | 2010-11-10 | 2011-04-13 | 中国医学科学院生物医学工程研究所 | Signal simulation method for electrical impedance gastric motility detection |
| CN204744169U (en) * | 2015-07-17 | 2015-11-11 | 中国医学科学院生物医学工程研究所 | A gastric emptying analogue means for electrical impedance formation of image detects |
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