CN104910272A - Method for changing fluidity of spray dried polypeptide powder - Google Patents
Method for changing fluidity of spray dried polypeptide powder Download PDFInfo
- Publication number
- CN104910272A CN104910272A CN201410103478.7A CN201410103478A CN104910272A CN 104910272 A CN104910272 A CN 104910272A CN 201410103478 A CN201410103478 A CN 201410103478A CN 104910272 A CN104910272 A CN 104910272A
- Authority
- CN
- China
- Prior art keywords
- organic solvent
- polypeptide powder
- spray dried
- product
- low
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 20
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 17
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 17
- 239000000843 powder Substances 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000007921 spray Substances 0.000 title claims abstract description 6
- 102000008186 Collagen Human genes 0.000 claims abstract description 13
- 108010035532 Collagen Proteins 0.000 claims abstract description 13
- 229920001436 collagen Polymers 0.000 claims abstract description 12
- 239000003960 organic solvent Substances 0.000 claims abstract description 8
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 6
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 238000009835 boiling Methods 0.000 claims abstract description 5
- 231100000053 low toxicity Toxicity 0.000 claims abstract description 5
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 4
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 238000005507 spraying Methods 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 2
- 230000001877 deodorizing effect Effects 0.000 claims description 2
- -1 polyethylene Polymers 0.000 abstract description 6
- 239000004698 Polyethylene Substances 0.000 abstract description 5
- 229920000573 polyethylene Polymers 0.000 abstract description 5
- 238000001694 spray drying Methods 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 239000004743 Polypropylene Substances 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
The invention discloses a method for changing the fluidity of spray dried polypeptide powder. The method includes: adding a non-toxic or low toxicity low-boiling point organic solvent into a decolored and deodorized collagen polypeptide solution, stirring the materials evenly, and then conducting spray drying. The protein polypeptide powder prepared by the invention has stacking density higher than that of collagen polypeptide powder products obtained by direct spray drying, the product has good fluidity and is difficult to stick polyethylene bags, and product waste is reduced. In addition, the organic solvent used in the invention has low boiling point, and has no toxicity and low toxicity, residual organic solvent does not exist after high temperature spray drying of the product, and the product quality is stable and reliable.
Description
Technical field
The invention belongs to biomedicine field, belong to a kind of working method of spraying dry polypeptide powder more specifically.
Background technology:
Current collagen protein and polypeptide spray-dried after the floury texture that obtains slim and graceful, be easily attached on polyethylene (PE) or polypropylene (PP) sealed bag, the easy like this waste causing raw material, rocks rear easy caking agglomerating simultaneously.
Summary of the invention:
For the problems referred to above, the object of the present invention is to provide a kind of under the prerequisite not changing collagen polypeptide content of powder and composition, solve the method that polypeptide powder easily adheres to polyethylene, Polypropylene Bag and easily assembles agglomerating problem.
The present invention is achieved by the following technical solutions.
Change a method for spray dried protein powder flowbility, its method is as follows: add low boiling point organic solvent that is nontoxic or low toxicity in the collagen polypeptide solution after decolouring and deodorizing, carry out spraying dry again after stirring.
Preferred as this technical scheme, described organic solvent is one or more in ethanol, Virahol, ethyl acetate, acetone.
Preferred as this technical scheme, described spray-dired inlet temperature is 155-170 DEG C, and temperature out is 65-73 DEG C.
Beneficial effect: the protein polypeptide powder bulk density that the present invention obtains is higher than the collagen polypeptide powder-product of the dry gained of Direct spraying, and good product mobility, not easily adheres to polyethylene bag, reduces the waste of product.In addition, low and the nontoxic and low toxicity of organic solvent boiling point that the present invention uses, product organic solvent-free after high temperature spray-drying remains, stable and reliable product quality.
Embodiment:
The following stated is only the preferred embodiment embodying object of the present invention, effect and technical characteristic, does not therefore limit protection scope of the present invention.
Embodiment 1:
Get carry out decolouring, the collagen polypeptid solution 500ml of taste removal, add alcohol and the 2.5ml acetone of 2.5ml, carry out spraying dry after stirring, inlet temperature 165 DEG C, temperature out 69 DEG C, obtains collagen polypeptide powder.
Embodiment 2:
Get carry out decolouring, the collagen polypeptid solution 500ml of taste removal, add the alcohol of 5ml, carry out spraying dry after stirring, inlet temperature 165 DEG C, temperature out 70 DEG C, obtains collagen polypeptide powder.
Embodiment 3:
Get carry out decolouring, the collagen polypeptid solution 500ml of taste removal, add alcohol and the 2.5ml ethyl acetate of 2.5ml, carry out spraying dry after stirring, inlet temperature 170 DEG C, temperature out 68 DEG C, obtains collagen polypeptide powder.
Claims (3)
1. change a method for spray dried protein powder flowbility, it is characterized in that: add low boiling point organic solvent that is nontoxic or low toxicity in the collagen polypeptide solution after decolouring and deodorizing, after stirring, carry out spraying dry again.
2. a kind of method changing spray dried protein powder flowbility according to claim 1, is characterized in that: described organic solvent is one or more in ethanol, Virahol, ethyl acetate, acetone.
3. a kind of method changing spray dried protein powder flowbility according to claim 1, it is characterized in that: described spray-dired inlet temperature is 155-170 DEG C, temperature out is 65-73 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410103478.7A CN104910272A (en) | 2014-03-14 | 2014-03-14 | Method for changing fluidity of spray dried polypeptide powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410103478.7A CN104910272A (en) | 2014-03-14 | 2014-03-14 | Method for changing fluidity of spray dried polypeptide powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104910272A true CN104910272A (en) | 2015-09-16 |
Family
ID=54079758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410103478.7A Pending CN104910272A (en) | 2014-03-14 | 2014-03-14 | Method for changing fluidity of spray dried polypeptide powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104910272A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102718862A (en) * | 2012-07-02 | 2012-10-10 | 集美大学 | Decolorizing and deodorizing method of collagen peptide of abyssal fishes |
| CN103409489A (en) * | 2013-08-15 | 2013-11-27 | 集美大学 | Preparation method for fish collagen antioxidant peptide |
-
2014
- 2014-03-14 CN CN201410103478.7A patent/CN104910272A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102718862A (en) * | 2012-07-02 | 2012-10-10 | 集美大学 | Decolorizing and deodorizing method of collagen peptide of abyssal fishes |
| CN103409489A (en) * | 2013-08-15 | 2013-11-27 | 集美大学 | Preparation method for fish collagen antioxidant peptide |
Non-Patent Citations (1)
| Title |
|---|
| 张彩虹 等: "《喷雾干燥改性白果粉的分散性及流动性研究》", 《生物质化学工程》 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Yang Jian Document name: Notification of Passing Examination on Formalities |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150916 |