CN104910055A - Method for extracting methionine - Google Patents
Method for extracting methionine Download PDFInfo
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- CN104910055A CN104910055A CN201510374961.3A CN201510374961A CN104910055A CN 104910055 A CN104910055 A CN 104910055A CN 201510374961 A CN201510374961 A CN 201510374961A CN 104910055 A CN104910055 A CN 104910055A
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- methionine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/584—Recycling of catalysts
Abstract
The invention provides a method for extracting methionine by continuous ion exchange. The method adopts a cation-exchange-resin-filled continuous ion exchange system to purify and extract a methionine solution, and the byproduct of the desorbent desorbing resin can be used for production of another industrial product. The technical process of the continuous ion exchange system comprises the following steps: exchanging, water washing, regenerating and regenerated water washing, wherein the exchange temperature is 50-70 DEG C, the exchange flow rate is 1-5 BV/h, and the regenerant is sulfuric acid, hydrochloric acid or hydrochloric acid with the concentration of 5-20%. Compared with the traditional production technique, the method enhances the product quality, lowers the cost and reduces the environmental protection pressure.
Description
Technical field
The invention belongs to chemical field, relate to the continuous ionic switching method that a kind of methionine(Met) extracts.
Background technology
Methionine(Met), also known as methionine(Met) or methylthio group Gamma Amino Butyric Acid, closely related with the metabolism of sulfocompound various in organism.When lacking methionine(Met), appetite stimulator can be caused, growth slow down or do not put on weight, the phenomenon such as kidney enlargement and the accumulation of liver iron, finally cause hepatic necrosis or fibrosis.
Current industrial production generally uses glycolylurea method to lay eggs next life propylhomoserin, and its typical process flow is as follows:
(1) ammonia Sweet natural gas and air catalytic reaction generate prussic acid, and prussic acid absorbs with sodium hydroxide solution and generates sodium cyanide;
(2) methylthio group generates methylmercaptoethyl propionyl gland (glycolylurea) for propionic aldehyde and the condensation of sodium cyanide ammonium hydrogencarbonate;
(3) glycolylurea basic hydrolysis becomes methionine(Met) sodium salt, then becomes methionine(Met) with sulphuric acid hydrolysis.
Traditional method to be laid eggs next life propylhomoserin with sulphuric acid hydrolysis methionine(Met) sodium salt in the flow process (3), its process need consume a large amount of sulfuric acid, if hydrolysis thoroughly can not have influence on purity and the yield of methionine(Met), in addition, the sodium sulfate byproduct that hydrolysis produces can occur with the crystallization of methionine(Met), causes by product cannot obtain utilization and improves its economic benefit.
Disclose one diatomite in patent 201310317849.2 " removing method and the device of impurity in secondary methionine mother liquor ", gac or atlapulgite remove method and the device of impurity in secondary methionine mother liquor.The continuous chromatography separation system disclosing a kind of sodium form or potassium type chromatography resin in patent 201310194709.5 " a kind of methionine(Met) production technique " is separated methionine(Met) crystalline mother solution.These two kinds of methods just all do not relate to for the magazins' layout in methionine(Met) crystalline mother solution process modification and the upgrading that methionine(Met) produces main flow.
Summary of the invention
The object of the present invention is to provide the methionine(Met) extraction process that a kind of good separating effect, running cost are low.
For achieving the above object, the technical scheme that the present invention proposes is: adopt continuous ionic exchange process to extract methionine(Met).Principle is the H utilized on Zeo-karb
+with the Na on Sodium L-methioninate
+exchange, Sodium L-methioninate transfers methionine(Met) to and enters in solution, can be used as by product and sell after exchanging the sodium ion strippant desorb on resin.Because sodium ions content in sodium methionine solution is up to about 3mol/L, as adopted traditional fixed bed system, resin loadings is too high, and one-time investment cost is too high, and needs to consume a large amount of chemical reagent.Therefore the present invention selects to have the Zeo-karb of highly selective and the Patents technology of the continuous ion exchange unit simultaneously adopting the applicant to apply for, the unique continuous ionic switching method that have developed methionine(Met) extraction.
The continuous ionic switching method that a kind of methionine(Met) of the present invention extracts, comprises the steps:
Step 1: by sodium methionine solution by being filled with the continuous ionic exchange system of Zeo-karb, obtain methionine solution and inorganic salt solution;
Step 2: the methionine solution obtained and inorganic salt are processed according to existing production technique.
Described Zeo-karb is strong-acid cation-exchange resin or weakly acidic cationic exchanger resin;
The technological process of described continuous ionic exchange system: mainly comprise exchange, washing, regeneration, regeneration washing;
The technological process of described continuous ionic exchange system, exchange temperature is 50-70 DEG C;
The technological process of described continuous ionic exchange system, exchange flow velocity is 1-5BV/h;
The technological process of described continuous ionic exchange system, regenerator is sulfuric acid, hydrochloric acid, the one in nitric acid;
The technological process of described continuous ionic exchange system, regenerator concentration is 5-20% (w/w);
The invention provides the continuous ionic switching method that a kind of methionine(Met) extracts, adopt the continuous ionic exchange system being filled with Zeo-karb, purification methionine solution, the by product that desorb resin obtains can be used for the production of another industrial goods.This method, compared with traditional production technique, improves quality product, reduces cost, alleviates environmental protection pressure.
Owing to not yet there being the processing method extracted for methionine(Met) resin method at present, therefore present method has originality, in generation economic benefit, have huge meaning.
Embodiment
Embodiment is used for further illustrating the present invention, and methionine solution used is from a Chongqing enterprise.
Embodiment 1
Get sodium methionine solution, methionine(Met) wherein containing 5.7% (w/w), feed temperature: 50 DEG C, (Xi'an Sunresin New Materials Co., Ltd.) is separated by the continuous ionic exchange system being filled with weakly acidic cationic exchanger resin LX-111, exchange flow velocity 1BV/h, obtain the methionine solution that content is 5.68% (w/w).Resin after exchange uses the sulphuric acid soln regeneration of 15% (w/w), obtains the metabisulfite solution that content is 16.70% (w/w).
Embodiment 2
Get sodium methionine solution, methionine(Met) wherein containing 6.3% (w/w), feed temperature: 60 DEG C, (Xi'an Sunresin New Materials Co., Ltd.) is separated by the continuous ionic exchange system being filled with strong-acid cation-exchange resin LX-160, exchange flow velocity 5BV/h, obtain the methionine solution that content is 6.26% (w/w).Resin after exchange uses the hydrochloric acid soln regenerating resin of 5% (w/w), obtains the sodium chloride solution that content is 14.3% (w/w).
Embodiment 3
Get sodium methionine solution, methionine(Met) wherein containing 6.0% (w/w), feed temperature: 70 DEG C, (Xi'an Sunresin New Materials Co., Ltd.) is separated by the continuous ionic exchange system being filled with weakly acidic cationic exchanger resin LX-111, exchange flow velocity 3BV/h, obtain the methionine solution that content is 5.99% (w/w).Resin after exchange uses the salpeter solution regenerating resin of 20% (w/w), obtains the sodium nitrate solution that content is 14.3% (w/w).
Obviously, above-described embodiment is only for example of the present invention is clearly described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (8)
1. a continuous ionic switching method for methionine(Met) extraction, is characterized in that, comprise the steps:
Step 1: by sodium methionine solution by being filled with the continuous ionic exchange system of Zeo-karb, obtain methionine solution and inorganic salt solution;
Step 2: the methionine solution obtained and inorganic salt solution are processed according to existing production technique.
2. the continuous ionic switching method of a kind of methionine(Met) extraction according to claim 1, described Zeo-karb is storng-acid cation exchange resin or weakly acidic cation-exchange resin.
3. the continuous ionic switching method of a kind of methionine(Met) extraction according to claim 1, the technological process of described continuous ionic exchange system: comprise exchange, washing, regeneration, regeneration washing.
4. the continuous ionic switching method of a kind of methionine(Met) extraction according to claim 3, described exchange temperature is 50-70 DEG C.
5. the continuous ionic switching method of a kind of methionine(Met) extraction according to claim 3, described exchange flow velocity is 1-5BV/h.
6. the continuous ionic switching method of a kind of methionine(Met) extraction according to claim 3, regenerator during described regeneration is selected from sulfuric acid, hydrochloric acid, nitric acid.
7. the continuous ionic switching method of a kind of methionine(Met) extraction according to claim 3, regenerator concentration during described regeneration is 5-20% (w/w).
8. the continuous ionic switching method of a kind of methionine(Met) extraction according to claim 3, is characterized in that comprising the steps:
Get sodium methionine solution, methionine(Met) wherein containing 5.7% (w/w), feed temperature: 50 DEG C, is separated by the continuous ionic exchange system being filled with weakly acidic cationic exchanger resin LX-111, exchange flow velocity 1BV/h, obtain the methionine solution that content is 5.68% (w/w).Resin after exchange uses the sulphuric acid soln regeneration of 15% (w/w), obtains the metabisulfite solution that content is 16.70% (w/w);
Or:
Get sodium methionine solution, methionine(Met) wherein containing 6.3% (w/w), feed temperature: 60 DEG C, is separated by the continuous ionic exchange system being filled with strong-acid cation-exchange resin LX-160, exchange flow velocity 5BV/h, obtain the methionine solution that content is 6.26% (w/w).Resin after exchange uses the hydrochloric acid soln regenerating resin of 5% (w/w), obtains the sodium chloride solution that content is 14.3% (w/w);
Or:
Get sodium methionine solution, methionine(Met) wherein containing 6.0% (w/w), feed temperature: 70 DEG C, is separated by the continuous ionic exchange system being filled with weakly acidic cationic exchanger resin LX-111, exchange flow velocity 3BV/h, obtain the methionine solution that content is 5.99% (w/w).Resin after exchange uses the salpeter solution regenerating resin of 20% (w/w), obtains the sodium nitrate solution that content is 14.3% (w/w).
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| CN201510374961.3A CN104910055A (en) | 2015-06-30 | 2015-06-30 | Method for extracting methionine |
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| CN201510374961.3A CN104910055A (en) | 2015-06-30 | 2015-06-30 | Method for extracting methionine |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018520146A (en) * | 2015-06-30 | 2018-07-26 | 西安藍暁科技新材料股▲ふん▼有限公司Ｓｕｎｒｅｓｉｎ Ｎｅｗ Ｍｅｔｅｒｉａｌｓ Ｃｏ．Ｌｔｄ，．Ｘｉ’Ａｎ | Process for purification of methionine |
| CN108658819A (en) * | 2017-06-13 | 2018-10-16 | 宁夏紫光天化蛋氨酸有限责任公司 | A kind of clean preparation method of methionine |
| CN108658820A (en) * | 2017-06-13 | 2018-10-16 | 宁夏紫光天化蛋氨酸有限责任公司 | Reduce the methionine production method of by-product sodium sulphate |
| CN110305050A (en) * | 2019-07-18 | 2019-10-08 | 宁夏紫光天化蛋氨酸有限责任公司 | A kind of method that 5- [2- (methyl mercapto) ethyl] glycolylurea hydrolysis exhaust prepares Sodium L-methioninate |
| US10669233B2 (en) | 2017-12-28 | 2020-06-02 | Sunresin New Materials Co. Ltd., Xi'an | Process of purifying methionine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2772026A1 (en) * | 1997-12-05 | 1999-06-11 | Rhone Poulenc Nutrition Animal | Preparation of methionine or its hydroxy analog using cation exchange resin |
| CN1950327A (en) * | 2004-04-07 | 2007-04-18 | 旭化成化学株式会社 | Method of purifying amino acid |
| CN103772246A (en) * | 2014-03-03 | 2014-05-07 | 重庆紫光化工股份有限公司 | Method and special equipment for preparing methionine employing ion-exchange acidification methionine salt |
| CN104003830A (en) * | 2014-01-27 | 2014-08-27 | 重庆紫光化工股份有限公司 | Method for separating amino acid and iminodicarboxylic acid from aqueous solution of alkali metal salt of amino acid |
-
2015
- 2015-06-30 CN CN201510374961.3A patent/CN104910055A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2772026A1 (en) * | 1997-12-05 | 1999-06-11 | Rhone Poulenc Nutrition Animal | Preparation of methionine or its hydroxy analog using cation exchange resin |
| CN1950327A (en) * | 2004-04-07 | 2007-04-18 | 旭化成化学株式会社 | Method of purifying amino acid |
| CN104003830A (en) * | 2014-01-27 | 2014-08-27 | 重庆紫光化工股份有限公司 | Method for separating amino acid and iminodicarboxylic acid from aqueous solution of alkali metal salt of amino acid |
| CN103772246A (en) * | 2014-03-03 | 2014-05-07 | 重庆紫光化工股份有限公司 | Method and special equipment for preparing methionine employing ion-exchange acidification methionine salt |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018520146A (en) * | 2015-06-30 | 2018-07-26 | 西安藍暁科技新材料股▲ふん▼有限公司Ｓｕｎｒｅｓｉｎ Ｎｅｗ Ｍｅｔｅｒｉａｌｓ Ｃｏ．Ｌｔｄ，．Ｘｉ’Ａｎ | Process for purification of methionine |
| EP3318552A4 (en) * | 2015-06-30 | 2019-02-20 | Sunresin New Meterials Co. Ltd., Xi'an | Process of purifying methionine |
| CN108658819A (en) * | 2017-06-13 | 2018-10-16 | 宁夏紫光天化蛋氨酸有限责任公司 | A kind of clean preparation method of methionine |
| CN108658820A (en) * | 2017-06-13 | 2018-10-16 | 宁夏紫光天化蛋氨酸有限责任公司 | Reduce the methionine production method of by-product sodium sulphate |
| US10669233B2 (en) | 2017-12-28 | 2020-06-02 | Sunresin New Materials Co. Ltd., Xi'an | Process of purifying methionine |
| CN110305050A (en) * | 2019-07-18 | 2019-10-08 | 宁夏紫光天化蛋氨酸有限责任公司 | A kind of method that 5- [2- (methyl mercapto) ethyl] glycolylurea hydrolysis exhaust prepares Sodium L-methioninate |
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| CB03 | Change of inventor or designer information |
Inventor after: Kou Xiaokang Inventor after: Luo Jibin Inventor after: Wei Yiyong Inventor after: Wang Risheng Inventor after: Wang Gang Inventor after: Liu Qiong Inventor after: Guo Fumin Inventor after: Wang Cheng Inventor after: Sun Biao Inventor after: Chen Shaotian Inventor after: Fan Wenmin Inventor before: Kou Xiaokang Inventor before: Luo Jibin Inventor before: Wang Risheng Inventor before: Wang Gang Inventor before: Liu Qiong Inventor before: Guo Fumin Inventor before: Wang Cheng Inventor before: Sun Biao Inventor before: Chen Shaotian Inventor before: Fan Wenmin |
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Effective date of registration: 20160726 Address after: High tech Zone technology two road 710075 Shaanxi city of Xi'an province No. 72 Chak tower four Applicant after: Sunresin New Materials Co., Ltd., Xi'an Applicant after: NINGXIA ZIGUANG TIANHUA METHIONINE CO., LTD. Address before: High tech Zone technology two road 710075 Shaanxi city of Xi'an province No. 72 Chak tower four Applicant before: Sunresin New Materials Co., Ltd., Xi'an |
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Application publication date: 20150916 |
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