CN104900364A - Super-paramagnetism Fe3O4/APTES composite nano particle and production method thereof - Google Patents

Super-paramagnetism Fe3O4/APTES composite nano particle and production method thereof Download PDF

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CN104900364A
CN104900364A CN201510228896.3A CN201510228896A CN104900364A CN 104900364 A CN104900364 A CN 104900364A CN 201510228896 A CN201510228896 A CN 201510228896A CN 104900364 A CN104900364 A CN 104900364A
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composite nanoparticle
aptes
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朱海军
梁超雄
吴婕
李倩雯
谭略
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Wuzhou product quality inspection institute
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Abstract

The invention discloses a super-paramagnetism Fe3O4/APTES composite nano particle and a production method thereof and belongs to the technical field of nano materials. The super-paramagnetism Fe3O4/APTES composite nano particle is good in product crystallinity, high in purity and uniform in particle distribution. According to the technical point, the composite nano particle is a Fe3O4 magnetic nano particle with silane coupling agent3- aminopropyltriethoxysilane decorated on the surface.

Description

Superparamagnetism Fe 3o 4/ APTES composite nanoparticle and preparation method thereof
Technical field
The present invention relates to a kind of composite nanoparticle, specifically, is a kind of superparamagnetism Fe 3o 4/ APTES composite nanoparticle, the invention still further relates to the preparation method of this nano particle, belongs to technical field of nano material.
Background technology
In recent years, nanometer technology has been widely used in multiple domain variability such as materialogy, electronics, biology and has obtained breakthrough, and the nano material wherein applying to biomedical sector is called as nano meter biomaterial.Fe in magnetic nano-particle 3o 4being most widely used of magnetic nano-particle.Because having superparamagnetic characteristic, non-immunogenic, hypotoxicity and good biocompatibility, and all there are many potential application in the field such as separation of immunoassays, targeted drug, DNA, become one of the study hotspot in Bio-Nano-Materials field.
At Fe 3o 4usually adopt coprecipitation in the preparation method of magnetic nano-particle, namely in the electrolyte solution being dissolved with various composition ion, add suitable precipitation reagent, react and generate the uniform precipitation of composition, precipitation heat decomposition obtains high purity nanometer powders material.Its advantage is: directly obtain the homogeneous nano-powder material of chemical composition by the various chemical reactions in solution, and the easy little and nano-powder material that is evenly distributed of prepared sizes.
When the size of magnetic nano-particle is in a certain critical dimension, namely super-paramagnetic state is entered, at this moment the anisotropy energy of particle and energy of thermal motion roughly the same, make the direction of easy axis that particle is not fixed, direction of easy axis is irregular change, one effect having an external magnetic field, molecular magnetic moment aligns at once, externally shows magnetic.Magnetization degree increases with the increase of external magnetic field strength, until arrive saturation magnetization.After externally-applied magnetic field disappears, magnetic particle demagnetizes immediately, does not almost have hysteresis.Under normal temperature, Fe 3o 4the critical dimension of magnetic nano-particle is 16nm.
Carry out Magnetic Isolation and guiding under making the effect of magnetic nano-particle outside magnetic field easily owing to having good magnetic responsiveness, and magnetic nano-particle can be not permanently magnetized in magnetic field, therefore not only safe but also be easy to control in vivo.
Square being directly proportional of the surface area of spheric granules and diameter, cube being directly proportional of its volume and diameter, therefore its specific area and diameter are inversely proportional to.Nano material due to the nano-particles size of its composition material little, the atom number that microparticle surfaces occupies is far more than the atom number that occupies of non-nano material ions surface of equal in quality.
The surface atom number of nano particle significantly increases along with the minimizing of nanoparticle size with the ratio of total atom number, high surface brings high surface energy, make particle surface atom extremely active, cause the surface energy of nano particle, skin effect that this phenomenon that surface tension significantly increases is called as nano material.
Because nano material has skin effect, the huge residue bonding power of surface atom makes nano particle be in upper state, for thermodynamic unstable system, can spontaneously reunite, be oxidized or adsorption to reduce unstable atomicity, to reduce the energy of system.
Magnetic Nano material has the skin effect of nano particle, and has strong gathering tendency due to the impact of magnetic, thus causes that grain diameter increases, dispersed less stable, have impact on its compatibility in biological tissues.And Fe 3o 4the non-oxidizability of colloidal solution is poor, is easy to oxidation by air and forms γ-Fe 2o 3particle, directly causes particle to occur to assemble and precipitation, must pass through finishing.Effectively can improve dispersiveness and the chemical stability of magnetic nano-particle after finishing, prevent from assembling, the biocompatibility of magnetic nano-particle is also well improved.
By the method for modifying of surface physics or chemistry, the multiple functional group with reactivity can be modified the surface of magnetic nano-particle.The activity functional groups being generally used for magnetic nano-particle finishing mainly contains four kinds: aldehyde radical (-CHO), hydroxyl (-OH), carboxyl (-COOH), amino (-NH2) etc.After these functional groups modify magnetic nano particle sub-surface, bioactive material can be had be connected by covalent bond mechanism of action with many.If with the various biomolecules bonding such as medicine, biology enzyme, immune protein, DNA or RNA, cell, realize it and better apply in various fields such as medicine, biomedical detections.
Summary of the invention
For the problems referred to above, the object of this invention is to provide a kind of product good crystallinity, there is higher purity, the superparamagnetism Fe of even particle size distribution 3o 4/ APTES composite nanoparticle.
Technical scheme provided by the invention is such:
A kind of superparamagnetism Fe 3o 4/ APTES composite nanoparticle, described composite nanoparticle is the Fe that finishing has silane coupler 3-aminopropyl triethoxysilane 3o 4magnetic nano-particle.
Further, above-mentioned superparamagnetism Fe 3o 4the preparation method of/APTES composite nanoparticle, comprises the steps: successively
1) get sub-boiling water, logical nitrogen deoxygenation, seals for subsequent use;
2) according to nFe 2+: nFe 3+=1:1.75 takes FeCl 24H 2o and FeCl 36H 2o, is dissolved in step 1) in the sub-boiling water of deoxygenation, be transferred in flask after dissolving completely, water bath with thermostatic control is heated, controlling reaction temperature is 80 DEG C, vigorous stirring under nitrogen protection, after reaction 1h, add rapidly 1.5M ammoniacal liquor 50mL, continue slowly to add 1.5M ammoniacal liquor, regulate pH to 9 ~ 10;
3) continue under nitrogen protection to stir constant temperature ageing 1 hour, after reaction terminates, be cooled to room temperature, Magneto separate, wash 2 times with ethanol, sub-boiling water washs 5 times, obtains Fe 3o 4magnetic fluid;
4) by Fe obtained above 3o 4nano particle is dissolved in ethanol/water solution, ultrasonic 30min, makes it dispersed;
5) 3-aminopropyl triethoxysilane is added, nitrogen protection, isothermal reaction 2h at 60 DEG C under stirring.After reaction terminates, be cooled to room temperature, Magneto separate, with absolute ethanol washing three times, sub-boiling water washs five times, and obtaining finishing has amino Fe 3o 4magnetic nano-particle; Finally be placed in vacuum drying oven 70 DEG C of dry 24h.
Further, above-mentioned superparamagnetism Fe 3o 4the preparation method of/APTES composite nanoparticle, described ethanol and water volume ratio 1: 1.
Compared with prior art, technical scheme provided by the invention adopts chemical coprecipitation successfully to prepare the Fe that finishing has silane coupler 3-aminopropyl triethoxysilane (APTES) 3o 4magnetic nano-particle.Silane coupler 3-aminopropyl triethoxysilane modifies Fe 3o 4reaction time needed for magnetic nano particle sub-surface can shorten greatly, can stop reaction after only needing sustained response 2h.Use transmission electron microscope observation Fe 3o 4the size of/APTES composite nanoparticle and form, result display Fe 3o 4the particle diameter of/APTES composite nanoparticle is 12.5nm, and product good crystallinity, has higher purity, and particle size distribution is also more even.VSM result display Fe 3o 4the saturation magnetization of/APTES composite nanoparticle is about 71.1emu/g, has superparamagnetism and excellent magnetic property.The Fe of amino functional 3o 4magnetic nano-particle has good biocompatibility, can the various biomolecules such as covalently bound enzyme, albumen, nucleic acid, medicine, and this will be conducive to the detection of magnetic nano-particle in biomedicine and application.
Accompanying drawing explanation
Fig. 1 amino silane modifies Fe 3o 4the reaction mechanism figure of nanoparticle surface;
Fig. 2 Fe 3o 4the infrared spectrum of/APTES composite nanoparticle;
Fig. 3 Fe 3o 4the XRD figure of/APTES composite nanoparticle;
Fig. 4 Fe 3o 4the TEM figure of/APTES composite nanoparticle;
Fig. 5 Fe 3o 4the B-H loop of/APTES composite nanoparticle.
Embodiment
Mode below by embodiment further illustrates the present invention, but does not form any limitation of the invention, and the amendment of anyone limited number of time made in right of the present invention is still in right of the present invention.
Embodiment 1
1 experimental section
1.2 instruments and reagent
Instrument: Rigaku D/max 2500v/pc type x-ray powder diffraction instrument (Rigaku); FT-IR Fourier transformation infrared spectrometer (Perkin Elmer Inc); JEM-2100 transmission electron microscope (Japan); MPMS-XL-7 superconductive quantum interference magnetic measurement system (Quantum Design company of the U.S.); DKB-501S super constant temperature water tank (the upper grand experimental facilities Co., Ltd of Nereid); The stepless constant speed stirrer of DW-3 digital display (Ying Yu Yu Hua instrument plant of Gongyi City); AR1140 electronic analytical balance (Ao Haosi (Shanghai) company); DZF-1B type vacuum drying chamber (Shanghai leap medical apparatus and instruments factory); SK3200H type ultrasonic cleaner (Shanghai High Kudos Science Instrument Co., Ltd.).
Reagent: FeCl 24H 2o (Xilong Chemical Co., Ltd); FeCl 36H 2o (Xilong Chemical Co., Ltd); Ammoniacal liquor (Xilong Chemical Co., Ltd); Absolute ethyl alcohol (Guangdong Guanghua Science and Technology Co., Ltd.); 3-aminopropyl triethoxysilane (APTES) (Alfa company of the U.S.); It is pure that experiment agents useful for same is analysis; Experimental water is sub-boiling water.
1.2.2Fe 3o 4the preparation of nano particle and surface amination thereof
Get the sub-boiling water of 200mL, logical nitrogen deoxygenation 30min, seals for subsequent use.1.9835gFeCl is got with electronic balance scale 24H 2o and 4.7302g FeCl 36H 2o (nFe 2+: nFe 3+=1:1.75); be dissolved in the sub-boiling water of 200mL deoxygenation; be transferred in 500mL three-neck flask after dissolving completely; water bath with thermostatic control is heated, and controlling reaction temperature is 80 DEG C, vigorous stirring under nitrogen protection; after reaction 1h; add rapidly 1.5M ammoniacal liquor 50mL, continue slowly to add 1.5M ammoniacal liquor, regulate pH to 9 ~ 10.Continue under nitrogen protection to stir constant temperature ageing 1 hour, after reaction terminates, be cooled to room temperature, Magneto separate, wash 2 times with ethanol, sub-boiling water washs 5 times, obtains pitch-black glossy Fe 3o 4magnetic fluid.Liquid-phase coprecipitation is adopted to prepare Fe 3o 4reaction principle can be expressed as follows:
Fe 2++2Fe 3++8OH -＝＝＝Fe 3O 4+4H 2O
By Fe obtained above 3o 4nano particle is dissolved in 150mL ethanol/water (volume ratio 1: 1) solution, and proceeds in 250mL three-neck flask, and ultrasonic 30min, makes it dispersed.A certain amount of (n Fe is added under stirring 3o 4: nAPTES=1:4) 3-aminopropyl triethoxysilane (NH 3c 3h 6si (OC 2h 5) 3), nitrogen protection, isothermal reaction 2h at 60 DEG C.After reaction terminates, be cooled to room temperature, Magneto separate, with absolute ethanol washing three times, sub-boiling water washs five times, and obtaining finishing has amino Fe 3o 4magnetic nano-particle.Finally be placed in vacuum drying oven 70 DEG C of dry 24h.
2, Fe 3o 4the sign of/APTES composite nanoparticle
2.1FT-IR test
Fe 3o 4/ APTES composite nanoparticle, after vacuumize, uses KBr pressed disc method, adopts the infrared spectrum of FT-IR Fourier transformation infrared spectrometer working sample.
2.2 particle diameters and morphological analysis
Use transmission electron microscope observation Fe 3o 4the size of/APTES composite nanoparticle and form, accelerating voltage is 200kV.
2.3XRD characterize
Fe 3o 4/ APTES composite nanoparticle, after vacuumize, measures with X-ray powder diffractometer, and diffraction source is copper target, λ=0.15418nm.
The mensuration of 2.4 magnetic performances
Fe 3o 4/ APTES composite nanoparticle, after vacuumize, measures its magnetic performance with vibrating specimen magnetometer.
3 results and discussion
3.1FT-IR analyze
3-aminopropyl triethoxysilane (APTES) is a kind of conventional silane coupler, is very easily hydrolyzed into silanol in aqueous.Using ammoniacal liquor as precipitation reagent by the Fe that coprecipitation is prepared 3o 4the a lot of hydroxyl of magnetic nano-particle adsorption.After adding silane coupling A PTES, first APTES is hydrolyzed generation silanol, then with Fe 3o 4the hydroxyl generation dehydration that magnetic nano-particle rich surface contains forms Fe-O-Si key, and silane coupler is adsorbed onto Fe by chemical action 3o 4the surface of magnetic nano-particle.Fig. 1 gives amino silane and modifies Fe 3o 4the reaction schematic diagram of nanoparticle surface.
The Fe being that Fig. 2 is corresponding 3o 4the infrared spectrogram of/APTES composite nanoparticle.In infrared spectrogram, be positioned at 3414cm -1the neighbouring peak occurred may be N-H stretching vibration absworption peak.And the peak that this region occurs may have occurred overlapping with the stretching vibration peak of hydroxyl (-OH).Be positioned at 1635cm -1neighbouring bands of a spectrum corresponding to the flexural vibrations of-OH, and be positioned at 2927cm -1and 1384cm -1bands of a spectrum respectively-C-H stretching vibration and in-plane bending vibration in correspondence-CH2-.Appear at 1071cm -1neighbouring absworption peak is then the symmetrical stretching vibration peak of Si-O-Si.At 632cm -1~ 585cm -1the bands of a spectrum occurred in scope show the existence of Fe-O key.603cm -1neighbouring strong absworption peak is then the stretching vibration peak of Fe-O key, shows Fe 3o 4existence.To sum up analyze, show that silane coupling A PTES successfully modifies Fe by chemical bonding effect 3o 4the surface of magnetic nano-particle.
3.2XRD analyze
X-ray diffraction (XRD) is one of most important technology of detecting material microstructure.Usually can carry out the qualitative and quantitative analysis of thing phase to material with X-ray diffraction.Fig. 3 is Fe 3o 4the XRD figure of/APTES composite nanoparticle.Fe 3o 4there is the sharp peak of the crystal diffraction of varying strength in/APTES composite nanoparticle, illustrate that its crystallinity is good, domain size distribution is narrower within the scope of 10-80 °.By analysis, its major diffraction spectrum peak appears at 2 θ=30.24 °, 35.70 °, 43.32 °, 53.71 °, 57.20 ° and 62.94 ° of corresponding Emission in Cubic Fe of difference 3o 4(220), (311), (400), (422), (511) and (440) crystal face.With Fe 3o 4diffraction spectra (JCPDS PDF:65-3107) contrasts basically identical, and significant change does not occur for crystal shape and the equal position of structure corresponding to diffraction maximum thereof, shows that prepared particle components is with Fe 3o 4be main.Fe 3o 4the average grain diameter of/APTES composite nanoparticle can be estimated by Scherrer equation D=k λ/(β cos θ), and wherein k=0.89, λ=0.15418nm, β is half-peak breadth.The average grain diameter that sample in Fig. 3 calculates sample according to the half-peak breadth of 2 θ=35.70 place peak positions is about 12.5nm.
3.3TEM analyze
Fig. 4 is the Fe adopting chemical coprecipitation to prepare 3o 4the TEM figure of/APTES composite nanoparticle.As can be seen from the figure, prepared product is spherical, and good dispersion, average grain diameter is about 12.5nm.By surface chemical modification method, silane coupling A PTES is modified Fe 3o 4behind the surface of nano particle, the dispersiveness of nano particle and chemical stability obtain very large improvement.Reunion between nano particle is effectively controlled.This compatibility for nano particle and biological tissue creates good condition.
3.4 magnetic property analyses
Magnetic hysteresis loop is the important curve characterizing magnetic material properties, it reflects the responding ability of magnetic material to changes of magnetic field.For investigating obtained Fe 3o 4the magnetic property of/APTES composite nanoparticle, we utilize vibrating specimen magnetometer (VSM) to measure under room temperature (300K) and have studied the macroscopic magnetization of sample.As shown in Figure 5, Fe in magnetization process 3o 4the magnetization (M) of/APTES composite nanoparticle increases along with the increase of applied field strengths, works as Fe 3o 4after the magnetization of/APTES composite nanoparticle reaches capacity and magnetizes, its magnetization no longer increases along with the increase of externally-applied magnetic field, but keeps its saturation magnetization value.When applied field strengths is reduced to zero gradually, its magnetization goes to zero thereupon, does not almost have hysteresis, and gained magnetic hysteresis loop is " S " type symmetrically, and remanent magnetization and coercive force also all go to zero.This illustrate prepared by Fe 3o 4/ APTES composite nanoparticle has superparamagnetism.According to magnetic hysteresis loop figure, draw Fe 3o 4the saturation magnetization of/APTES composite nanoparticle is about 71.1emu/g.
Test of many times finds, the Fe herein 3o 4/ APTES composite nanoparticle can be uniformly dispersed in the aqueous solution.When there being externally-applied magnetic field to exist, Fe 3o 4/ APTES composite nanoparticle can be enriched in rapidly on bottle wall, and around dispersion liquid becomes clear, and this is because magnetic nano-particle kernel has caused by ferromagnetism, this with the magnetic property measurement result that composite nanoparticle carries out is matched.After externally-applied magnetic field is removed, through violent jolting, Fe 3o 4/ APTES composite nanoparticle can be scattered in solution again soon again.Based on the good magnetic responsiveness that magnetic nano-particle has, can be applied on the separation and purification of protein, target medicine carrier.
The present invention adopt chemical coprecipitation successfully to prepare Fe that finishing has silane coupler 3-aminopropyl triethoxysilane (APTES) 3o 4magnetic nano-particle.In technical scheme provided by the invention, silane coupler 3-aminopropyl triethoxysilane modifies Fe 3o 4reaction time needed for magnetic nano particle sub-surface can shorten greatly, can stop reaction after only needing sustained response 2h.Use transmission electron microscope observation Fe 3o 4the size of/APTES composite nanoparticle and form, result display Fe 3o 4the particle diameter of/APTES composite nanoparticle is 12.5nm, and product good crystallinity, has higher purity, and particle size distribution is also more even.VSM result display Fe 3o 4the saturation magnetization of/APTES composite nanoparticle is about 71.1emu/g, has superparamagnetism and excellent magnetic property.The Fe of amino functional 3o 4magnetic nano-particle has good biocompatibility, can the various biomolecules such as covalently bound enzyme, albumen, nucleic acid, medicine, and this will be conducive to the detection of magnetic nano-particle in biomedicine and application.

Claims (3)

1. a superparamagnetic Fe 3o 4/ APTES composite nanoparticle, is characterized in that, described composite nanoparticle is the Fe that finishing has silane coupler 3-aminopropyl triethoxysilane 3o 4magnetic nano-particle.
2. prepare superparamagnetism Fe according to claim 1 3o 4the method of/APTES composite nanoparticle, is characterized in that, comprises the steps: successively
1) get sub-boiling water, logical nitrogen deoxygenation, seals for subsequent use;
2) according to nFe 2+: nFe 3+=1:1.75 takes FeCl 24H 2o and FeCl 36H 2o, is dissolved in step 1) in the sub-boiling water of deoxygenation, be transferred in flask after dissolving completely, water bath with thermostatic control is heated, controlling reaction temperature is 80 DEG C, vigorous stirring under nitrogen protection, after reaction 1h, add rapidly 1.5M ammoniacal liquor 50mL, continue slowly to add 1.5M ammoniacal liquor, regulate pH to 9 ~ 10;
3) continue under nitrogen protection to stir constant temperature ageing 1 hour, after reaction terminates, be cooled to room temperature, Magneto separate, wash 2 times with ethanol, sub-boiling water washs 5 times, obtains Fe 3o 4magnetic fluid;
4) by Fe obtained above 3o 4nano particle is dissolved in ethanol/water solution, ultrasonic 30min, makes it dispersed;
5) 3-aminopropyl triethoxysilane is added, nitrogen protection, isothermal reaction 2h at 60 DEG C under stirring.After reaction terminates, be cooled to room temperature, Magneto separate, with absolute ethanol washing three times, sub-boiling water washs five times, and obtaining finishing has amino Fe 3o 4magnetic nano-particle; Finally be placed in vacuum drying oven 70 DEG C of dry 24h.
3. superparamagnetism Fe according to claim 2 3o 4the preparation method of/APTES composite nanoparticle, is characterized in that, described ethanol and water volume ratio 1: 1.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109317108A (en) * 2018-12-06 2019-02-12 环境保护部华南环境科学研究所 A kind of magnetic composite nano material and its preparation method and application
CN109513454A (en) * 2018-11-30 2019-03-26 湘潭大学 One kind preparing MoS by coulomb interaction2/C3N4The method of composite photo-catalyst
CN110066632A (en) * 2019-04-26 2019-07-30 南京林业大学 A method of preparing the adhesive with electromagnetic wave shielding performance
CN110615510A (en) * 2019-10-08 2019-12-27 青岛科技大学 Amino-functionalized magnetic ferroferric oxide nano particle and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021286A1 (en) * 2007-08-13 2009-02-19 The University Of Queensland Organosilica encapsulated nanoparticles
CN101905151A (en) * 2010-08-12 2010-12-08 南昌航空大学 Preparation method and applications of magnetic metal ion surface imprinted polymer
CN102225785A (en) * 2011-04-26 2011-10-26 东华大学 Preparation method of APTS (aminopropyltriethoxysilane)-modified iron oxide magnetic nanoparticles
CN103100358A (en) * 2012-12-20 2013-05-15 华南理工大学 Magnetic nanometer ion liquid composite particles as well as preparation method and application thereof
CN104549081A (en) * 2013-10-21 2015-04-29 大连市沙河口区中小微企业服务中心 Surface amine modification method of magnetic microsphere
CN104835608A (en) * 2015-05-07 2015-08-12 梧州市产品质量检验所 Superparamagnetic Fe3O4/APTES (Aminopropyltriethoxysilane) composite nanoparticles and characterization method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021286A1 (en) * 2007-08-13 2009-02-19 The University Of Queensland Organosilica encapsulated nanoparticles
CN101905151A (en) * 2010-08-12 2010-12-08 南昌航空大学 Preparation method and applications of magnetic metal ion surface imprinted polymer
CN102225785A (en) * 2011-04-26 2011-10-26 东华大学 Preparation method of APTS (aminopropyltriethoxysilane)-modified iron oxide magnetic nanoparticles
CN103100358A (en) * 2012-12-20 2013-05-15 华南理工大学 Magnetic nanometer ion liquid composite particles as well as preparation method and application thereof
CN104549081A (en) * 2013-10-21 2015-04-29 大连市沙河口区中小微企业服务中心 Surface amine modification method of magnetic microsphere
CN104835608A (en) * 2015-05-07 2015-08-12 梧州市产品质量检验所 Superparamagnetic Fe3O4/APTES (Aminopropyltriethoxysilane) composite nanoparticles and characterization method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
冯斌等: "3-氨丙基三乙氧基硅烷表面修饰的磁性Fe3O4纳米粒子合成与表征", 《化工新型材料》 *
胡玮等: "四氧化三铁磁性纳米微粒表面的氨基化修饰", 《化学研究》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109513454A (en) * 2018-11-30 2019-03-26 湘潭大学 One kind preparing MoS by coulomb interaction2/C3N4The method of composite photo-catalyst
CN109513454B (en) * 2018-11-30 2021-07-23 湘潭大学 Preparation of MoS by Coulomb interaction2/C3N4Method for preparing composite photocatalyst
CN109317108A (en) * 2018-12-06 2019-02-12 环境保护部华南环境科学研究所 A kind of magnetic composite nano material and its preparation method and application
CN110066632A (en) * 2019-04-26 2019-07-30 南京林业大学 A method of preparing the adhesive with electromagnetic wave shielding performance
CN110066632B (en) * 2019-04-26 2021-04-09 南京林业大学 Method for preparing adhesive with electromagnetic wave shielding performance
CN110615510A (en) * 2019-10-08 2019-12-27 青岛科技大学 Amino-functionalized magnetic ferroferric oxide nano particle and preparation method thereof
CN110615510B (en) * 2019-10-08 2021-12-28 青岛科技大学 Amino-functionalized magnetic ferroferric oxide nano particle and preparation method thereof

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