CN104897449A - Method for configuring human tissue dielectric property simulating material - Google Patents
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Abstract
The invention relates to the technical field of biophysics, particularly to a method for configuring a human tissue dielectric property simulating material. The method comprises the following steps: firstly, preparing a formula sample, then measuring and determining the dielectric property of the formula sample, establishing a functional relation of regulatory factors of the dielectric property and the formula sample proportion, and finally solving various formula proportions of the dielectric property simulating material coordinated with any specified conductivity and dielectric constant by utilizing the established functional relation of the regulatory factors of the dielectric property and the formula proportion, so as to prepare the appointed simulating material. Through adoption of the method for quick calculation to obtain the mixing proportion of various materials in the formula of the human tissue dielectric property simulating material, the dielectric property simulating material coordinated with any specified conductivity and dielectric constant can be conveniently and quickly configured.
Description
Technical field
The present invention relates to biophysical technology field, be specifically related to a kind of collocation method of tissue dielectric property simulation material.
Background technology
Material can be regarded as the build-in attribute of material in the electromagnetic property that elect magnetic field shows, and tissue is no exception.Tissue can show certain electrical characteristics and magnetic characteristic at elect magnetic field.Electrical characteristics, sometimes also referred to as dielectric property (EPs), mainly refer to conductivity and the permittivity (being specific inductive capacity again) of tissue, magnetic characteristic refers to the magnetic permeability of tissue.Generally speaking, tissue is non-magnetic material, and its magnetic permeability, close to the magnetic permeability in vacuum, can be counted as constant.Tissue EPs is everywhere relevant with organizing the cell membrane of insulation of interior non-uniform Distribution and the electrolytic solution of conduction etc., therefore organizes EPs everywhere to distribute and presents heterogeneity, and have frequency dependence.
The mechanism of action of research electromagnetic field and biological tissue and action effect are one of very important field of scientific studies, correlative study achievement, for the healthy cause of the mankind has made tremendous contribution.Such as, magnetic resonance imaging (MRI) system, its essence is exactly the strong interactional system of static magnetic field, gradient magnetic, radio-frequency (RF) magnetic field and tissue, has become now one of requisite important large-scale image documentation equipment of clinical disease diagnosis; For another example, various electromagnetic physiotherapy equipment, electromagnetic focusing tumour thermal ablation therapy equipment etc., its essence is all the electromagnetic field of different shape and the system with interaction of tissue.In addition, the interactional non-thermal effect of electromagnetic field and tissue is studied, and also having a lot of problem not solve, is also one of the study hotspot in biophysics field at present.When studying above-mentioned electromagnetic field and tissue interaction relationship, obtaining electromagnetic field in in-house distribution is crucial research contents.The method of one of them, is exactly that development can the artificial material of simulated human tissue dielectric property, adopts such artificial material to carry out simulated human tissue distribution, then obtain the distribution of electromagnetic field in material by the measurement of Electric and magnetic fields.
In the past few decades, many scholars put forward Various Tissues dielectric property simulation material.Generally speaking, these simulation materials are generally liquid, solid and gel (semisolid) form, and because colloidal material has Physical similarity with tissue, and they can simulate and organize dielectric property on a large scale, therefore most popular.According to basis, the simulation material of these glues can be divided into a few class, and the short summary of current correlative study is listed in Table 1.The holding time of the dielectric material proposed by Chou et al (1984) and Surowiec et al (1992) is very limited, even if also can only preserve two weeks in the container of sealing; Simultaneously, the dielectric material (Chou et al 1984) be made up of TX-150, polyethylene powder, aluminium powder, water and sodium chloride, and the dielectric material (Ito et al 2001, Onishi and Uebayashi 2006) to be made up of TX-151, agar, polyethylene powder, sodium chloride and water can not simulate the tissue of low water content.Marchal et al (1989) and Sunaga et al (2003) proposes a kind of dielectric material based on gelatin-water and carrys out simulated tissue, but can sovent diffusion be there is, so these materials can not make the thermal map with long-time stability when directly contacting placement in the bi-material of different gelatin concentration.A kind of by Lazebnik et al (2005), oil-gelatin materials that Lai et al (2011) and Bakar et al (2011) proposes can simulate the dielectric property of various biological tissue in very large frequency range, has long-time stability simultaneously.But because this kind of material only adopts the percent by volume of oil as adjustable factors, cause the change of relative dielectric constant and conductivity to be mutually related, therefore the method can not simultaneously the accurate analog relative dielectric constant of specifying arbitrarily and conductivity.Yuan et al (2012) adds sodium chloride on the basis of oil-gelatin materials, adopts percent by volume and sodium chloride concentration two adjustable factors of oil.The combination of simulating different relative dielectric constants and conductivity is so just made to become possibility.But any one in the percent by volume and these two adjustable factors of sodium chloride concentration of adjustment oil, because of the period of the day from 11 p.m. to 1 a.m, all can make relative dielectric constant and conductivity change simultaneously.The simulation material obtaining various tissue (the hundreds of organization type comprised under various health physio-pathological condition different from tumour) is caused to become the loaded down with trivial details work of an exception.
In sum, existing simulation material configuring technical all directly cannot obtain the ratio of the various formulas of the dielectric property simulation material of conductivity and the specific inductive capacity collocation of specifying arbitrarily, needs the method providing one can calculate the ratio of " the various formulas with the simulation material of the dielectric property of conductivity and the specific inductive capacity collocation of specifying arbitrarily " badly.
Summary of the invention
The object of the invention is to the collocation method that a kind of tissue dielectric property simulation material is provided for the deficiencies in the prior art, adopt Technology of Data Fitting to calculate the method for the blending ratio of various material in acquisition tissue dielectric property simulation material formula fast, employing the method can configure the dielectric property simulation material of conductivity and the specific inductive capacity collocation of specifying arbitrarily quickly and easily.
The present invention is achieved through the following technical solutions this object:
A collocation method for tissue dielectric property simulation material, comprises the following steps:
1) prepare some formula samples, described formula sample packages oil scraper, sodium chloride, gelatin, p-methylbenzoic acid, n-propanol, surfactant, deionized water and formaldehyde, described formula sample is arranged in pairs or groups from low to high according to the content of oil and sodium chloride;
2) measure the dielectric property confirming described formula sample, repetitive measurement calculating mean value and relative standard deviation, again make the undesirable sample of relative standard deviation and measure dielectric property;
3) set up the funtcional relationship between dielectric property and formula sample proportion regulatory factor, described formula rate regulatory factor is respectively the content of oil and the content of sodium chloride;
4) utilize the functional relation between the dielectric property containing many regulatory factors set up and formula rate, solve the various formula rates of the simulation material of the dielectric property of conductivity and the specific inductive capacity collocation of specifying arbitrarily, the simulation material specified by preparation.
Wherein, the preparation of described formula sample is carried out according to following steps:
A, add the n-propanol of 0.1 ~ 0.5g p-methylbenzoic acid and 5 ~ 15mL in a reservoir, be heated to 30 ~ 50 DEG C and stir p-methylbenzoic acid is fully dissolved;
B, continue the deionized water adding 85 ~ 95mL in container, the temperature of deionized water remains room temperature;
C, continue in container, add 15 ~ 20g gelatin, make gelatin fully invade bubble in the solution and keep room temperature condition;
D, utilize film type material by container closure and normal temperature leave standstill 3 ~ 4h;
E, on film type material, prick out some duck eyes, container is positioned in the water-bath of 65 ~ 70 DEG C and heats 10 ~ 15min;
F, fully to stir until gelatin dissolves obtained gelatin solution completely, remove blibbing, be cooled to 50 DEG C for subsequent use;
G, oil is heated to 50 DEG C for subsequent use;
H, respectively the gelatin solution of 100 ~ 20mL and the oil of 0 ~ 80mL to be joined in another container in order, and add the sodium chloride of 0 ~ 1.40g respectively, and keep the temperature of solution to be 50 DEG C;
I, vigorous stirring until all oilings be droplet dispersion in the solution, add the surfactant of 0.5 ~ 10mL, and be stirred well to solution close to white;
J, continue the formalin adding 10 ~ 15mL in container, continue stirring until evenly, according to the ratio collocation of different oil and gelatin, complete the preparation of formula sample;
K, by preparation formula sample sealing In Shade, until formula sample solidify completely.
Wherein, described formula sample comprises some groups, and every oil of group of formula sample and the ratio of gelatin are fixed, and the content of sodium chloride is arranged in pairs or groups from low to high, and between each group, the ratio of oil is arranged in pairs or groups from low to high, and the ratio of gelatin is arranged in pairs or groups from high to low.
As preferably, the content of oil, gelatin and sodium chloride in described each formula sample adds according to following content:
Wherein, described step 2) be specially: adopt the coaxial cable of the female matched impedance in 50 Europe as probe, probe is inserted in formula sample to be measured, network analyzer is utilized to measure net coefficients, get the mean value of the result of repetitive measurement, utilize beginning coaxial probe method dielectric property measuring principle, calculate the dielectric property of tested formula sample; The method of the distribution of the dielectric property measuring sample different parts is adopted to assess the homogeneity of formula sample, each sample is divided into different piece, at the surface measurement diverse location of different piece, at each position repetitive measurement, and clean coaxial cable probe with paper handkerchief after measuring each point, prevent the greasy dirt on popping one's head in from affecting result;
Last calculating mean value and relative standard deviation, again make the undesirable sample of relative standard deviation and again remeasure electrical characteristics.
As preferably, the concrete steps of described assessment formula sample homogeneity are: each formula sample is divided into two halves, containing three surfaces, for each surface measurement 5 diverse locations, 5 measurement data are recorded in each position, collect 75 groups of measurement data altogether from each formula sample; Before measuring each position, coaxial cable probe is fixed on measurement point 10-15 minute;
Last calculating mean value and relative standard deviation, again make the sample of relative standard deviation more than 5% and measure electrical characteristics.
Wherein, described step 3) be specially:
Using the content of oil and the content of the sodium chloride regulatory factor as formulation content ratio, under identical sodium chloride concentration, relative dielectric constant is expressed as the single order polynomial expression of the percent by volume about oil, and expression formula is as follows:
ε'＝m(N)+n(N)O, (1)
Wherein, ε ' expression relative dielectric constant, O is the percent by volume (0%-80%) of oil, m (N) and n (N) is the coefficient about N, N is sodium chloride concentration, one group of m (N) and n (N) two coefficients relation with sodium chloride concentration is obtained under each different sodium chloride concentration, Coefficient m (N) is represented by the linear equation about N, and n (N) is represented by quadratic equation, the relation therefore between relative dielectric constant and two adjustable factors represents by following formula:
ε'＝a
0+a
1N+(a
2+a
3N+a
4N
2)O. (2)
Wherein, a
0to a
4it is equation coefficient;
Under identical oil volume number percent, conductivity is expressed as the single order polynomial expression about sodium chloride concentration, and expression formula is as follows:
σ＝f(O)+g(O)N, (3)
Wherein, σ represents relative dielectric constant (S/m), N is sodium chloride concentration, f (O) and g (O) is the coefficient about O, O is the percent by volume of oil, one group of f (O) and g (O) two coefficients relation with oil volume number percent is obtained under each different oil volume number percent, coefficient f (O) is represented by the cubic equation about O, and g (O) is represented by quadratic equation, the relation therefore between conductivity and two adjustable factors represents by following formula:
σ＝b
0+b
1O+b
2O
2+b
3O
3+(b
4+b
5O+b
6O
2)N. (4)
Wherein, b
0to b
6it is equation coefficient;
Wherein, equation coefficient a
0to a
4, b
0to b
6according to the dielectric property measuring each formula sample obtained, nonlinear least square method data fitting computing method can be adopted to calculate and to obtain.
Relative to prior art, beneficial effect of the present invention is: the collocation method of tissue dielectric property simulation material of the present invention, first the preparation of formula sample is carried out, then the dielectric property confirming described formula sample is measured, and the funtcional relationship set up between dielectric property and formula sample proportion regulatory factor, finally utilize the functional relation between the dielectric property containing many regulatory factors and formula rate set up, solve the various formula rates of the simulation material of the dielectric property of conductivity and the specific inductive capacity collocation of specifying arbitrarily, simulation material specified by preparation, the present invention adopts Technology of Data Fitting to calculate the method for the blending ratio of various material in acquisition tissue dielectric property simulation material formula fast, and employing the method can configure the dielectric property simulation material of conductivity and the specific inductive capacity collocation of specifying arbitrarily quickly and easily.
Accompanying drawing explanation
Fig. 1 is the formula rate schematic diagram of simulation material of the present invention.
Fig. 2 is the content schematic diagram of relative dielectric constant with oil.
Fig. 3 is the content schematic diagram of m (N) with sodium chloride.
Fig. 4 is the content schematic diagram of n (N) with sodium chloride.
Fig. 5 is the content schematic diagram of conductivity with sodium chloride.
Fig. 6 is the content schematic diagram of f (O) with oil.
Fig. 7 is the content schematic diagram of g (O) with oil.
Fig. 8 is the instrumentation plan of dielectric property.
In figure: 1-computing machine, 2-network analyzer, 3-coaxial cable, 4-formula sample to be measured.
Embodiment
Describe the present invention below in conjunction with drawings and the specific embodiments.
Embodiment.
The collocation method of a kind of tissue dielectric property simulation material of the present embodiment, comprises the following steps:
1) some formula samples are prepared, described formula sample packages oil scraper (peanut oil), sodium chloride, gelatin, p-methylbenzoic acid, n-propanol, surfactant, deionized water and formaldehyde, described formula sample is arranged in pairs or groups from low to high according to the content of oil and sodium chloride;
Wherein, the preparation of described formula sample is carried out according to following steps:
A, add the n-propanol of 0.1 ~ 0.5g p-methylbenzoic acid and 5 ~ 15mL in a reservoir, be heated to 30 ~ 50 DEG C and stir p-methylbenzoic acid is fully dissolved;
B, continue the deionized water adding 85 ~ 95mL in container, the temperature of deionized water remains room temperature;
C, continue in container, add 15 ~ 20g gelatin, make gelatin fully invade bubble in the solution and keep room temperature condition;
D, utilize film type material by container closure and normal temperature leave standstill 3 ~ 4h;
E, on film type material, prick out some duck eyes, container is positioned in the water-bath of 65 ~ 70 DEG C and heats 10 ~ 15min;
F, fully to stir until gelatin dissolves obtained gelatin solution completely, remove blibbing, be cooled to 50 DEG C for subsequent use;
G, oil is heated to 50 DEG C for subsequent use;
H, respectively the gelatin solution of 100 ~ 20mL and the oil of 0 ~ 80mL to be joined in another container in order, and add the sodium chloride of 0 ~ 1.40g respectively, and keep the temperature of solution to be 50 DEG C;
I, vigorous stirring until all oilings be droplet dispersion in the solution, add the surfactant of 0.5 ~ 10mL, and be stirred well to solution close to white;
J, continue the formalin adding 10 ~ 15mL in container, continue stirring until evenly, according to the ratio collocation of different oil and gelatin, complete the preparation of formula sample;
K, by preparation formula sample sealing In Shade, until formula sample solidify completely.
Wherein, described formula sample comprises some groups, every oil of group of formula sample and the ratio of gelatin are fixed, the content of sodium chloride is arranged in pairs or groups from low to high, between each group, the ratio of oil is arranged in pairs or groups from low to high, the ratio of gelatin is arranged in pairs or groups from high to low, and the content of oil, gelatin and sodium chloride in described each formula sample adds according to following content:
2) measure the dielectric property confirming described formula sample, repetitive measurement calculating mean value and relative standard deviation, again make the undesirable formula sample of relative standard deviation and measure dielectric property:
As shown in Figure 8, coaxial cable 3 is utilized to be connected with network analyzer 2 by formula sample 4 to be measured, then network analyzer 2 is electrically connected with computing machine 1, adopt the coaxial cable 3 of the female matched impedance in 50 Europe as probe, probe is inserted in formula sample 4 to be measured, utilizes network analyzer 2 to measure net coefficients, get the mean value of the result of repetitive measurement, utilize beginning coaxial probe method dielectric property measuring principle, calculate the dielectric property of tested formula sample; The method of the distribution of the dielectric property measuring sample different parts is adopted to assess the homogeneity of formula sample, each sample is divided into different piece, at the surface measurement diverse location of different piece, at each position repetitive measurement, and clean coaxial cable 3 with paper handkerchief after measuring each point to pop one's head in, prevent the greasy dirt on popping one's head in from affecting result;
Last calculating mean value and relative standard deviation, again make the undesirable sample of relative standard deviation and again remeasure dielectric property.
As preferably, the concrete steps of described assessment formula sample homogeneity are: each formula sample is divided into two halves, containing three surfaces, for each surface measurement 5 diverse locations, 5 measurement data are recorded in each position, collect 75 groups of measurement data altogether from each formula sample; Before measuring each position, coaxial cable 3 probe is fixed on measurement point 10-15 minute;
Last calculating mean value and relative standard deviation, again make the sample of relative standard deviation more than 5% and measure electrical characteristics.
3) funtcional relationship between dielectric property and formula sample proportion regulatory factor is set up:
Using the content of oil and the content of the sodium chloride regulatory factor as formulation content ratio, under identical sodium chloride concentration, relative dielectric constant is expressed as the single order polynomial expression of the percent by volume about oil, and expression formula is as follows:
ε'＝m(N)+n(N)O, (1)
Wherein, ε ' expression relative dielectric constant, O is the percent by volume (0%-80%) of oil, m (N) and n (N) is the coefficient about N, N is sodium chloride concentration, one group of m (N) and n (N) two coefficients relation with sodium chloride concentration is obtained under each different sodium chloride concentration, Coefficient m (N) is represented by the linear equation about N, and n (N) is represented by quadratic equation, the relation therefore between relative dielectric constant and two adjustable factors represents by following formula:
ε'＝a
0+a
1N+(a
2+a
3N+a
4N
2)O. (2)
Wherein, a
0to a
4it is equation coefficient;
Under identical oil volume number percent, conductivity is expressed as the single order polynomial expression about sodium chloride concentration, and expression formula is as follows:
σ＝f(O)+g(O)N, (3)
Wherein, σ represents relative dielectric constant (S/m), N is sodium chloride concentration, f (O) and g (O) is the coefficient about O, O is the percent by volume of oil, one group of f (O) and g (O) two coefficients relation with oil volume number percent is obtained under each different oil volume number percent, coefficient f (O) is represented by the cubic equation about O, and g (O) is represented by quadratic equation, the relation therefore between conductivity and two adjustable factors represents by following formula:
σ＝b
0+b
1O+b
2O
2+b
3O
3+(b
4+b
5O+b
6O
2)N. (4)
Wherein, b
0to b
6it is equation coefficient;
Wherein, relative dielectric constant with oil content relation as shown in Figure 2, m (N) with sodium chloride content relation as shown in Figure 3, n (N) with sodium chloride content relation as shown in Figure 4, conductivity with sodium chloride content relation as shown in Figure 5, f (O) with oil content relation as shown in Figure 6, g (O) with oil content relation as shown in Figure 7.
Wherein, equation coefficient a
0to a
4, b
0to b
6according to the formula sample measurement data obtained, can be calculated by nonlinear least square method: according to the dielectric property measuring each formula sample obtained, adopt nonlinear least square method data fitting computing method, the value obtaining each equation coefficient is as follows:
a
0＝63.63[63.30,64.95]；
a
1＝9.899[8.26,11.53]；
a
2＝-64.22[-67.26,-61.17]；
a
3＝-0.06711[-8.54,8.41]；
a
4＝-3.041[-9.01,2.93].
b
0＝0.1315[0.084,0.179]；10
b
1＝-0.7346[-1.225,-0.244]；
b
2＝2.667[1.245,4.088]；
b
3＝-2.399[-3.545,-1.252]；
b
4＝0.9264[0.873,0.980]；
b
5＝0.6479[0.254,1.042]；
b
6＝-1.741[-2.344,-1.139].
4) functional relation between the dielectric property containing many regulatory factors set up and formula rate is utilized, solve the various formula rates of the simulation material of the dielectric property of conductivity and the specific inductive capacity collocation of specifying arbitrarily, the formula rate of simulation material of the present invention as shown in Figure 1, can prepare specified simulation material easily and fast according to various formula rate.
The above embodiment only have expressed some embodiments of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (8)
1. a collocation method for tissue dielectric property simulation material, is characterized in that, comprises the following steps:
1) prepare some formula samples, described formula sample packages oil scraper, sodium chloride, gelatin, p-methylbenzoic acid, n-propanol, surfactant, deionized water and formaldehyde, described formula sample is arranged in pairs or groups from low to high according to the content of oil and sodium chloride;
2) measure the dielectric property confirming described formula sample, repetitive measurement calculating mean value and relative standard deviation, again make the undesirable sample of relative standard deviation and measure dielectric property;
3) set up the funtcional relationship between dielectric property and formula sample proportion regulatory factor, described formula rate regulatory factor is respectively the content of oil and the content of sodium chloride;
4) utilize the functional relation between the dielectric property containing many regulatory factors set up and formula rate, solve the various formula rates of the simulation material of the dielectric property of conductivity and the specific inductive capacity collocation of specifying arbitrarily, the simulation material specified by preparation.
2. the collocation method of tissue dielectric property simulation material according to claim 1, is characterized in that, the preparation of described formula sample is carried out according to following steps:
A, add the n-propanol of 0.1 ~ 0.5g p-methylbenzoic acid and 5 ~ 15mL in a reservoir, be heated to 30 ~ 50 DEG C and stir p-methylbenzoic acid is fully dissolved;
B, continue the deionized water adding 85 ~ 95mL in container, the temperature of deionized water remains room temperature;
C, continue in container, add 15 ~ 20g gelatin, make gelatin fully invade bubble in the solution and keep room temperature condition;
D, utilize film type material by container closure and normal temperature leave standstill 3 ~ 4h;
E, on film type material, prick out some duck eyes, container is positioned in the water-bath of 65 ~ 70 DEG C and heats 10 ~ 15min;
F, fully to stir until gelatin dissolves obtained gelatin solution completely, remove blibbing, be cooled to 50 DEG C for subsequent use;
G, oil is heated to 50 DEG C for subsequent use;
H, respectively the gelatin solution of 100 ~ 20mL and the oil of 0 ~ 80mL to be joined in another container in order, and add the sodium chloride of 0 ~ 1.40g respectively, and keep the temperature of solution to be 50 DEG C;
I, vigorous stirring until all oilings be droplet dispersion in the solution, add the surfactant of 0.5 ~ 10mL, and be stirred well to solution close to white;
J, continue the formalin adding 10 ~ 15mL in container, continue stirring until evenly, according to the ratio collocation of different oil and gelatin, complete the preparation of formula sample;
K, by preparation formula sample sealing In Shade, until formula sample solidify completely.
3. the collocation method of tissue dielectric property simulation material according to claim 2, it is characterized in that, described formula sample comprises some groups, every oil of group of formula sample and the ratio of gelatin are fixed, the content of sodium chloride is arranged in pairs or groups from low to high, between each group, the ratio of oil is arranged in pairs or groups from low to high, and the ratio of gelatin is arranged in pairs or groups from high to low.
4. the collocation method of tissue dielectric property simulation material according to claim 3, is characterized in that, the content of oil, gelatin and sodium chloride in described each formula sample adds according to following content:
5. the collocation method of tissue dielectric property simulation material according to claim 1, it is characterized in that, described step 2) be specially: adopt the coaxial cable of the female matched impedance in 50 Europe as probe, probe is inserted in formula sample to be measured, network analyzer is utilized to measure net coefficients, get the mean value of the result of repetitive measurement, utilize beginning coaxial probe method dielectric property measuring principle, calculate the dielectric property of tested formula sample; The method of the distribution of the dielectric property measuring sample different parts is adopted to assess the homogeneity of formula sample, each sample is divided into different piece, at the surface measurement diverse location of different piece, at each position repetitive measurement, and clean coaxial cable probe with paper handkerchief after measuring each point, prevent the greasy dirt on popping one's head in from affecting result;
Last calculating mean value and relative standard deviation, again make the undesirable sample of relative standard deviation and again remeasure electrical characteristics.
6. the collocation method of tissue dielectric property simulation material according to claim 5, it is characterized in that, the concrete steps of described assessment formula sample homogeneity are: each formula sample is divided into two halves, containing three surfaces, for each surface measurement 5 diverse locations, 5 measurement data are recorded in each position, collect 75 groups of measurement data altogether from each formula sample; Before measuring each position, coaxial cable probe is fixed on measurement point 10-15 minute;
Last calculating mean value and relative standard deviation, again make the sample of relative standard deviation more than 5% and measure electrical characteristics.
7. the collocation method of tissue dielectric property simulation material according to claim 1, is characterized in that, described step 3) be specially:
Using the content of oil and the content of the sodium chloride regulatory factor as formulation content ratio, under identical sodium chloride concentration, relative dielectric constant is expressed as the single order polynomial expression of the percent by volume about oil, and expression formula is as follows:
ε'＝m(N)+n(N)O, (1)
Wherein, ε ' expression relative dielectric constant, O is the percent by volume of oil, m (N) and n (N) is the coefficient about N, N is sodium chloride concentration, one group of m (N) and n (N) two coefficients relation with sodium chloride concentration is obtained under each different sodium chloride concentration, Coefficient m (N) is represented by the linear equation about N, and n (N) is represented by quadratic equation, the relation therefore between relative dielectric constant and two adjustable factors represents by following formula:
ε'＝a
0+a
1N+(a
2+a
3N+a
4N
2)O. (2)
Wherein, a
0to a
4it is equation coefficient;
Under identical oil volume number percent, conductivity is expressed as the single order polynomial expression about sodium chloride concentration, and expression formula is as follows:
σ＝f(O)+g(O)N, (3)
Wherein, σ represents relative dielectric constant (S/m), N is sodium chloride concentration, f (O) and g (O) is the coefficient about O, O is the percent by volume of oil, one group of f (O) and g (O) two coefficients relation with oil volume number percent is obtained under each different oil volume number percent, coefficient f (O) is represented by the cubic equation about O, and g (O) is represented by quadratic equation, the relation therefore between conductivity and two adjustable factors represents by following formula:
σ＝b
0+b
1O+b
2O
2+b
3O
3+(b
4+b
5O+b
6O
2)N. (4)
Wherein, b
0to b
6it is equation coefficient.
8. the collocation method of tissue dielectric property simulation material according to claim 7, is characterized in that, described equation coefficient a
0to a
4, b
0to b
6according to the dielectric property measuring each formula sample obtained, nonlinear least square method data fitting computing method can be adopted to calculate and to obtain.
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| CN106682451A (en) * | 2016-12-08 | 2017-05-17 | 深圳先进技术研究院 | Formula proportion determining method for biological tissue simulation material and system |
| CN110082400A (en) * | 2019-04-26 | 2019-08-02 | 上海海洋大学 | A kind of method of content of starch in quick detection minced fillet |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077943A1 (en) * | 2002-04-05 | 2004-04-22 | Meaney Paul M. | Systems and methods for 3-D data acquisition for microwave imaging |
-
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077943A1 (en) * | 2002-04-05 | 2004-04-22 | Meaney Paul M. | Systems and methods for 3-D data acquisition for microwave imaging |
Non-Patent Citations (4)
| Title |
|---|
| C. MARCHAL ET AL.: "Dielectric properties of gelatine phantoms used for simulation of biological tissues between 10 and 50 MHz", 《INT. J. HYPERTHERMIA》 * |
| YU YUAN ET AL.: "A heterogeneous human tissue mimicking phantom for RF heating and MRI thermal monitoring verificaiton", 《PHYSICS IN MEDICINE AND BIOLOGY》 * |
| 王浩然等: "人体肺部组织介电特性实验研究", 《中国生物医学工程学报》 * |
| 蔡占秀等: "正常乳腺脂肪与腺体组织介电特性研究", 《医疗卫生装备》 * |
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| WO2018103131A1 (en) * | 2016-12-08 | 2018-06-14 | 深圳先进技术研究院 | Method and system for determining formula proportions of biological tissue simulation material |
| CN106682451B (en) * | 2016-12-08 | 2019-05-14 | 深圳先进技术研究院 | A kind of formula rate of biological tissue's simulation material determines method and system |
| CN110082400A (en) * | 2019-04-26 | 2019-08-02 | 上海海洋大学 | A kind of method of content of starch in quick detection minced fillet |
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