CN104888034B - External application Chinese medicine treats the purposes of diarrhea - Google Patents
External application Chinese medicine treats the purposes of diarrhea Download PDFInfo
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Abstract
The present invention is a kind of purposes of Chinese medicine preparation in the external application application for preparing treatment diarrhea, and the Chinese medicine preparation is made of the bulk pharmaceutical chemicals of following parts by weight：15 20 parts of radix bupleuri, 5 10 parts of dried orange peel, 5 10 parts of rhizoma cyperi, 10 15 parts of Rhizoma Atractylodis Macrocephalae, 5 10 parts of Radix Glycyrrhizae, 5 10 parts of Chinese yam, 15 20 parts of sophora flower, 5 10 parts of psoralea corylifolia, 15 20 parts of coninshaped blueberry branchlet and leaf, 10 15 parts of rhizoma anemarrhenae, 10 15 parts of the vine of multiflower knotweed, 10 15 parts of moutan bark, 5 10 parts of Chinese cassia tree, 5 10 parts of adlay, 5 10 parts of cortex albiziae, 5 10 parts of Radix Angelicae Sinensis, 10 15 parts of corydalis tuber, 5 10 parts of the root of three-nerved spicebush, 38 parts of radix rehmanniae preparata, 28 parts of spina date seed, 5 10 parts of campanulaceae.Treating functional diarrhea has good curative effect, and utilization is simple and easy to do, has no toxic side effect, easy to patients, is a kind of Chinese medicine preparation for safely and effectively treating functional diarrhea, has a good application prospect.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, being a kind of Chinese medicine preparation in the external application application for preparing treatment diarrhea
Purposes.
Background technology
Diarrhea-type irritable bowel syndrome (IBS-D) is one of clinical common functional intestines problem, it is characterized in that enteron aisle
Though it is excessive to enteron aisle stimulation physiological reaction without organic disease, it shows as abdominal pain, diarrhea, carry a large amount of mucus in excrement sometimes,
It is touching refractory due to its recurrent exerbation, thus seriously affect the quality of life of patient.Irritable bowel syndrome be it is a kind of with abdominal pain or
The Functional Gastrointestinal Disease that abdominal discomfort changes with bowl evacuation habit mostly occurs in the young and the middle aged, and women is more than male, male to female ratio 1：
2.With the continuous quickening of modern society's life rhythm, which rises year by year.Although functional diarrhea symptom weight is not
Together, it but is easy to generate human body larger psychological impact, seriously affects people’s lives quality.Doctor trained in Western medicine is to irritable bowel syndrome institute
Caused functional diarrhea multiselect gastrointestinal antispasmodic drug and antidiarrheic treatment, such as pinaverium bromide, Loperamide or diphenoxylate
Deng, though Western medicine antidiarrheic effect is good, should not be used for a long time, long-time service can lead to pharmacological dependence and dosage more use it is bigger, very
It may to intractable constipation occurs.In clinical observation for many years, Chinese traditional medicine navel therapeutic has curative effect as a kind of traditional naturopathy
Significantly, compliance is good, and securely and reliably, the advantages such as few side effects show unique characteristics in clinical application.
Invention content
The purpose of the present invention is being directed to deficiency in the prior art, a kind of Chinese medicine preparation is provided and is preparing the outer for the treatment of diarrhea
With the purposes in application.
To achieve the above object, the technical solution adopted by the present invention is that：A kind of Chinese medicine preparation is preparing the outer for the treatment of diarrhea
With the purposes in application, 15-20 parts of radix bupleuri is made by the bulk pharmaceutical chemicals of following parts by weight in the Chinese medicine preparation, 5-10 parts of dried orange peel,
5-10 parts of rhizoma cyperi, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 5-10 parts of Radix Glycyrrhizae, 5-10 parts of Chinese yam, 15-20 parts of sophora flower, 5-10 parts of psoralea corylifolia, stone melon seeds
15-20 parts of lotus, 10-15 parts of rhizoma anemarrhenae, 10-15 parts of the vine of multiflower knotweed, 10-15 parts of moutan bark, 5-10 parts of Chinese cassia tree, 5-10 parts of adlay, silk tree
5-10 parts of skin, 5-10 parts of Radix Angelicae Sinensis, 10-15 parts of corydalis tuber, 5-10 parts of the root of three-nerved spicebush, 3-8 parts of radix rehmanniae preparata, 2-8 parts of spina date seed, campanulaceae 5-10
Part.
It is preferred that the Chinese medicine preparation is made of the bulk pharmaceutical chemicals of following parts by weight：17-19 parts of radix bupleuri, 7-9 parts of dried orange peel, rhizoma cyperi
7-9 parts, 12-14 parts of Rhizoma Atractylodis Macrocephalae, 7-9 parts of Radix Glycyrrhizae, 7-9 parts of Chinese yam, 17-19 parts of sophora flower, 7-9 parts of psoralea corylifolia, coninshaped blueberry branchlet and leaf 17-19
Part, 12-14 parts of rhizoma anemarrhenae, 12-14 parts of the vine of multiflower knotweed, 12-14 parts of moutan bark, 7-9 parts of Chinese cassia tree, 7-9 parts of adlay, 7-9 parts of cortex albiziae, when
Return 7-9 parts, 12-14 parts of corydalis tuber, 7-9 parts of the root of three-nerved spicebush, 5-6 parts of radix rehmanniae preparata, 4-6 parts of spina date seed, 7-9 parts of campanulaceae.
It is preferred that the Chinese medicine preparation is made of the bulk pharmaceutical chemicals of following parts by weight：18 parts of radix bupleuri, 8 parts of dried orange peel, 8 parts of rhizoma cyperi,
13 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Radix Glycyrrhizae, 8 parts of Chinese yam, 18 parts of sophora flower, 8 parts of psoralea corylifolia, 18 parts of coninshaped blueberry branchlet and leaf, 13 parts of rhizoma anemarrhenae, 13 parts of the vine of multiflower knotweed,
13 parts of moutan bark, 8 parts of Chinese cassia tree, 8 parts of adlay, 8 parts of cortex albiziae, 8 parts of Radix Angelicae Sinensis, 13 parts of corydalis tuber, 8 parts of the root of three-nerved spicebush, 5 parts of radix rehmanniae preparata, wild jujube
5 parts of benevolence, 8 parts of campanulaceae.
The invention has the advantages that：
The external application Chinese medicine application therapy functional diarrhea of the present invention has good curative effect, and uses simple and easy to do, drug
Transdermal absorption avoids liver kidney circulation, has no toxic side effect, easy to patients, is that one kind safely and effectively treating functional diarrhea
Chinese medicine preparation, have a good application prospect.
Specific implementation mode
It elaborates to specific implementation mode provided by the invention with reference to embodiment.
Embodiment 1
18 parts of radix bupleuri, 8 parts of dried orange peel, 8 parts of rhizoma cyperi, 13 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Radix Glycyrrhizae, 8 parts of Chinese yam, 18 parts of sophora flower, 8 parts of psoralea corylifolia,
18 parts of coninshaped blueberry branchlet and leaf, 13 parts of rhizoma anemarrhenae, 13 parts of the vine of multiflower knotweed, 13 parts of moutan bark, 8 parts of Chinese cassia tree, 8 parts of adlay, 8 parts of cortex albiziae, Radix Angelicae Sinensis 8
Part, 13 parts of corydalis tuber, 8 parts of the root of three-nerved spicebush, 5 parts of radix rehmanniae preparata, 5 parts of spina date seed, 8 parts of campanulaceae.
Bulk pharmaceutical chemicals are weighed according to proportioning, add water to cook secondary, 6 times of amount water are added for the first time, second is added 6 times of amount water,
1.5 hours every time, merging secondary decocting liquid, filters, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 DEG C survey), and 80
DEG C it is dried, crushed into fine powder, is sieved up to traditional Chinese medicinal extract powder.It by above-mentioned traditional Chinese medicinal extract powder, is modulated with honey, size, which is made, is
2.0cm × 2.0cm, the application of thickness about 1.5cm.
Embodiment 2
20 parts of radix bupleuri, 5 parts of dried orange peel, 5 parts of rhizoma cyperi, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Radix Glycyrrhizae, 5 parts of Chinese yam, 15 parts of sophora flower, psoralea corylifolia 10
Part, 15 parts of coninshaped blueberry branchlet and leaf, 15 parts of rhizoma anemarrhenae, 10 parts of the vine of multiflower knotweed, 10 parts of moutan bark, 5 parts of Chinese cassia tree, 5 parts of adlay, 5 parts of cortex albiziae, Radix Angelicae Sinensis
5 parts, 15 parts of corydalis tuber, 5 parts of the root of three-nerved spicebush, 3 parts of radix rehmanniae preparata, 2 parts of spina date seed, 5 parts of campanulaceae.
Bulk pharmaceutical chemicals are weighed according to proportioning, add water to cook secondary, 6 times of amount water are added for the first time, second is added 6 times of amount water,
1.5 hours every time, merging secondary decocting liquid, filters, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 DEG C survey), and 80
DEG C it is dried, crushed into fine powder, is sieved up to traditional Chinese medicinal extract powder.It by above-mentioned traditional Chinese medicinal extract powder, is modulated with honey, size, which is made, is
2.0cm × 2.0cm, the application of thickness about 1.5cm.
Embodiment 3
19 parts of radix bupleuri, 6 parts of dried orange peel, 6 parts of rhizoma cyperi, 11 parts of Rhizoma Atractylodis Macrocephalae, 6 parts of Radix Glycyrrhizae, 6 parts of Chinese yam, 16 parts of sophora flower, 9 parts of psoralea corylifolia,
16 parts of coninshaped blueberry branchlet and leaf, 14 parts of rhizoma anemarrhenae, 11 parts of the vine of multiflower knotweed, 11 parts of moutan bark, 6 parts of Chinese cassia tree, 6 parts of adlay, 6 parts of cortex albiziae, Radix Angelicae Sinensis 6
Part, 14 parts of corydalis tuber, 6 parts of the root of three-nerved spicebush, 4 parts of radix rehmanniae preparata, 3 parts of spina date seed, 6 parts of campanulaceae.
Bulk pharmaceutical chemicals are weighed according to proportioning, add water to cook secondary, 6 times of amount water are added for the first time, second is added 6 times of amount water,
1.5 hours every time, merging secondary decocting liquid, filters, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 DEG C survey), and 80
DEG C it is dried, crushed into fine powder, is sieved up to traditional Chinese medicinal extract powder.It by above-mentioned traditional Chinese medicinal extract powder, is modulated with honey, size, which is made, is
2.0cm × 2.0cm, the application of thickness about 1.5cm.
Embodiment 4
17 parts of radix bupleuri, 7 parts of dried orange peel, 7 parts of rhizoma cyperi, 12 parts of Rhizoma Atractylodis Macrocephalae, 7 parts of Radix Glycyrrhizae, 7 parts of Chinese yam, 17 parts of sophora flower, 7 parts of psoralea corylifolia,
17 parts of coninshaped blueberry branchlet and leaf, 12 parts of rhizoma anemarrhenae, 12 parts of the vine of multiflower knotweed, 12 parts of moutan bark, 7 parts of Chinese cassia tree, 7 parts of adlay, 7 parts of cortex albiziae, Radix Angelicae Sinensis 7
Part, 12 parts of corydalis tuber, 7 parts of the root of three-nerved spicebush, 6 parts of radix rehmanniae preparata, 4 parts of spina date seed, 7 parts of campanulaceae.
Bulk pharmaceutical chemicals are weighed according to proportioning, add water to cook secondary, 6 times of amount water are added for the first time, second is added 6 times of amount water,
1.5 hours every time, merging secondary decocting liquid, filters, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 DEG C survey), and 80
DEG C it is dried, crushed into fine powder, is sieved up to traditional Chinese medicinal extract powder.It by above-mentioned traditional Chinese medicinal extract powder, is modulated with honey, size, which is made, is
2.0cm × 2.0cm, the application of thickness about 1.5cm.
Embodiment 5
16 parts of radix bupleuri, 9 parts of dried orange peel, 9 parts of rhizoma cyperi, 14 parts of Rhizoma Atractylodis Macrocephalae, 9 parts of Radix Glycyrrhizae, 9 parts of Chinese yam, 19 parts of sophora flower, 6 parts of psoralea corylifolia,
19 parts of coninshaped blueberry branchlet and leaf, 11 parts of rhizoma anemarrhenae, 14 parts of the vine of multiflower knotweed, 14 parts of moutan bark, 9 parts of Chinese cassia tree, 9 parts of adlay, 9 parts of cortex albiziae, Radix Angelicae Sinensis 9
Part, 11 parts of corydalis tuber, 9 parts of the root of three-nerved spicebush, 7 parts of radix rehmanniae preparata, 6 parts of spina date seed, 9 parts of campanulaceae.
Bulk pharmaceutical chemicals are weighed according to proportioning, add water to cook secondary, 6 times of amount water are added for the first time, second is added 6 times of amount water,
1.5 hours every time, merging secondary decocting liquid, filters, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 DEG C survey), and 80
DEG C it is dried, crushed into fine powder, is sieved up to traditional Chinese medicinal extract powder.It by above-mentioned traditional Chinese medicinal extract powder, is modulated with honey, size, which is made, is
2.0cm × 2.0cm, the application of thickness about 1.5cm.
Embodiment 6
15 parts of radix bupleuri, 10 parts of dried orange peel, 10 parts of rhizoma cyperi, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Glycyrrhizae, 10 parts of Chinese yam, 20 parts of sophora flower, psoralea corylifolia
5 parts, 20 parts of coninshaped blueberry branchlet and leaf, 10 parts of rhizoma anemarrhenae, 15 parts of the vine of multiflower knotweed, 15 parts of moutan bark, 10 parts of Chinese cassia tree, 10 parts of adlay, 10 parts of cortex albiziae,
10 parts of Radix Angelicae Sinensis, 10 parts of corydalis tuber, 10 parts of the root of three-nerved spicebush, 8 parts of radix rehmanniae preparata, 8 parts of spina date seed, 10 parts of campanulaceae.
Bulk pharmaceutical chemicals are weighed according to proportioning, add water to cook secondary, 6 times of amount water are added for the first time, second is added 6 times of amount water,
1.5 hours every time, merging secondary decocting liquid, filters, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 DEG C survey), and 80
DEG C it is dried, crushed into fine powder, is sieved up to traditional Chinese medicinal extract powder.It by above-mentioned traditional Chinese medicinal extract powder, is modulated with honey, size, which is made, is
2.0cm × 2.0cm, the application of thickness about 1.5cm.
Embodiment 7
1. clinical data
1.1 general information
Whole totally 60 patients.Wherein man 22, female 38 are randomly divided into two groups for the treatment of group, one group of control and control, often
20 people of group.Treatment group's average age 48.1 years old, average course of disease 3.2 years；Control group average age 46.9 years old, average course of disease 3.4 years,
Symptom integral compares no significant (P before t examines the age for showing two groups of patients, gender, the course of disease, treatment>0.05).
1.2 diagnosis and inclusion criteria：Using meeting 2006《Irritable bowel syndrome and Rome III diagnostic criteria》, through phase
It closes clinical examination and excludes the enteron aisle organic disease person for causing diarrhea.Adhere to this experiment and the person that signs informed consent form.
1.3 exclusion criteria：Organic enterogastric diseases history, gastrointestinal surgery history, diabetic have received other related
Treatment, may influence the effect index observer of this research；The gestational period prepares gravid woman, disagrees and this experimenter is added.
2. therapy
Treatment group：The application being prepared using embodiment 1, gauze are fixed, and are externally applied to umbilical region, and shine in infrared lamp
It penetrates, 20 minutes every time, 2 times/d.
Compare one group：Herbal application is made of the raw material of following parts by weight：20 parts of radix bupleuri, 5 parts of dried orange peel, 5 parts of rhizoma cyperi, mountain
5 parts of medicine, 3 parts of radix rehmanniae preparata, 2 parts of spina date seed, 5 parts of campanulaceae, windproof 5 parts, 5 parts of lotus seeds, 10 parts of Schisandra chinensis, preparation method and embodiment 1
Identical, gauze is fixed, and is externally applied to umbilical region, and in infra-red light irradiation, 20 minutes every time, 2 times/d.
Compare two groups：Give dioctahedral smectite 3g, 2 times/d.
Three groups of equal 7d are 1 course for the treatment of, observe 3 courses for the treatment of.Three groups of cases are required to establish rational diet and living habit.
3. observation index
3.1 clinical efficacy；
3.2 pretherapy and post-treatment cardinal symptom integral variations（Abdominal pain, diarrhea, abdominal distension, defecate urgent, rectal tenesmus, lassitude hypodynamia
Deng）, cardinal symptom degree presses《New Chinese medicine guideline of clinical investigations（It is tentative）》With 4 point-scores evaluate, by symptom it is light, in,
Severe remembers 1,2,3 points respectively, asymptomatic then 0 point of note.
4. curative effect determinate standard
Reference《New Chinese medicine guideline of clinical investigations（It is tentative）》.Curative effect index=(before treatment after symptom total score-treatment
Symptom total score) preceding symptom total score × 100% of/treatment.Recovery from illness：Cardinal symptom disappears, and stool forming, mucus disappears；It is effective：Mainly
Symptom is obviously improved, and syndrome integral reduces >=70%；Effectively：Symptom, syndrome integral reduce >=30%；In vain：Symptom is without obviously changing
Kind, even aggravating, syndrome integral is reduced<30%..
5. statistical method
For statistical analysis using SPSS13.0, measurement data meets normal distribution person t and examines, otherwise rank sum test；Meter
Number data uses Chi-square Test.
6. clinical effectiveness
6.1 3 groups of Clinical efficacy comparisons（Table 1）, treatment group's total effective rate 95%, one group 70% of control, two group 60% of control,
Three groups are compared, and treatment group's effective percentage is significantly better than control group（P < 0.05）.
1 three groups of curative effects of table compare
| Project | Recovery from illness | It is effective | Effectively | In vain | It is efficient |
| Treatment group（n=20） | 3 | 15 | 1 | 1 | 95% |
| Compare one group（n=20） | 0 | 5 | 9 | 6 | 70% |
| Compare two groups（n=20） | 0 | 4 | 8 | 8 | 60% |
6.2 3 groups of pretherapy and post-treatment cardinal symptom integral contrasts（Table 2）
The pretherapy and post-treatment symptom integral variation of 2 three groups of table（±S）
Note：Compared with one group of control, * P ＜ 0.05；Compared with two groups of control, #P ＜ 0.05；Compare before and after treatment with group▲P
＜ 0.05.
Clinical test results are shown：The external application Chinese medicine application therapy functional diarrhea of the present invention has good curative effect, group
Between compare that there are significant differences（P ＜ 0.05）, abdominal pain, diarrhea, abdominal distension, stool urgent, rectal tenesmus, tired can be effectively relieved
Idle weak equal diseases, and simple and easy to do, Drug Percutaneous Absorption is used, liver kidney circulation is avoided, is had no toxic side effect, it is easy to patients,
It is a kind of Chinese medicine preparation for safely and effectively treating functional diarrhea, has a good application prospect.
Claims (1)
1. a kind of purposes of Chinese medicine preparation in the external application application for preparing treatment diarrhea, which is characterized in that the Chinese medicine preparation
It is made of the bulk pharmaceutical chemicals of following parts by weight：18 parts of radix bupleuri, 8 parts of dried orange peel, 8 parts of rhizoma cyperi, 13 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Radix Glycyrrhizae, 8 parts of Chinese yam, Chinese scholartree
Spend 18 parts, 8 parts of psoralea corylifolia, 18 parts of coninshaped blueberry branchlet and leaf, 13 parts of rhizoma anemarrhenae, 13 parts of the vine of multiflower knotweed, 13 parts of moutan bark, 8 parts of Chinese cassia tree, 8 parts of adlay,
8 parts of cortex albiziae, 8 parts of Radix Angelicae Sinensis, 13 parts of corydalis tuber, 8 parts of the root of three-nerved spicebush, 5 parts of radix rehmanniae preparata, 5 parts of spina date seed, 8 parts of campanulaceae.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961497A (en) * | 2012-11-29 | 2013-03-13 | 王吉坤 | Chinese herbal compound prescription used for treating chronic diarrhea |
| CN103690869A (en) * | 2013-12-10 | 2014-04-02 | 柳州市中医院 | Traditional Chinese medicine for treating irritable bowel syndrome and preparation method thereof |
| CN103816520A (en) * | 2014-03-13 | 2014-05-28 | 荣昌制药(淄博)有限公司 | Externally-applied Chinese traditional medicine preparation for treating chronic functional diarrhea and preparation method thereof |
| CN104474451A (en) * | 2014-12-30 | 2015-04-01 | 代建德 | Diarrhea cure pill |
-
2015
- 2015-05-24 CN CN201510265932.3A patent/CN104888034B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961497A (en) * | 2012-11-29 | 2013-03-13 | 王吉坤 | Chinese herbal compound prescription used for treating chronic diarrhea |
| CN103690869A (en) * | 2013-12-10 | 2014-04-02 | 柳州市中医院 | Traditional Chinese medicine for treating irritable bowel syndrome and preparation method thereof |
| CN103816520A (en) * | 2014-03-13 | 2014-05-28 | 荣昌制药(淄博)有限公司 | Externally-applied Chinese traditional medicine preparation for treating chronic functional diarrhea and preparation method thereof |
| CN104474451A (en) * | 2014-12-30 | 2015-04-01 | 代建德 | Diarrhea cure pill |
Non-Patent Citations (1)
| Title |
|---|
| "中医药治疗肠易激综合征用药规律分析";赵健等;《中医学报》;20150331;第30卷(第4期);第588页"2.4.2 IBS腹泻型" * |
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