CN104887672A - Broad-spectrum anticancer and cancer prevention formula medicine - Google Patents
Broad-spectrum anticancer and cancer prevention formula medicine Download PDFInfo
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- CN104887672A CN104887672A CN201510287646.7A CN201510287646A CN104887672A CN 104887672 A CN104887672 A CN 104887672A CN 201510287646 A CN201510287646 A CN 201510287646A CN 104887672 A CN104887672 A CN 104887672A
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- vitamin
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- cimetidine
- verapamil
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Abstract
The invention provides a broad-spectrum anticancer and cancer prevention formula medicine comprising the components of diclofenac sodium, vitamin B6, cimetidine, anarexol and verapamil. The broad-spectrum anticancer and cancer prevention formula medicine provided by the invention can be used for widely treating and preventing various cancers and is significant in treatment effect.
Description
Technical field
The invention belongs to the pharmaceutical compounding techniques field of Therapeutic cancer.
Background technology
Existing cancer therapy drug is numerous, but often kind of medicine is all the cancer for treatment single kind or approximate kind, and curative effect is also exactly so to comply with one's wishes, and often side effect is larger, does not also possess the effect of broad-spectrum cancer-treating and anti-cancer.
Summary of the invention
Object of the present invention is just in order to the efficacy of drugs solving existing Therapeutic cancer is single, often kind of medicine can only treat the deficiency of the cancer of single kind or the cancer of approximate kind, and side effect is large and provide one extensively to treat and prevent various cancer and therapeutic effect significant broad spectrum anticancer anticarcinogen formula.
Object of the present invention is achieved through the following technical solutions:
A kind of broad spectrum anticancer anti-cancer magistral medicines, the present invention is characterised in that, this medicine component is: diclofenac sodium, vitamin B
6, cimetidine, cyproheptadine hydrochloride, verapamil.
The optimum formula once taken of magistral medicines component of the present invention is: diclofenac sodium 50 ~ 70mg, vitamin B
620mg, cimetidine 0.2 ~ 0.4g, cyproheptadine hydrochloride 5 ~ 7mg, verapamil 40 ~ 60mg; Above-mentioned prescription medicine is simultaneously oral.
The present invention is for improving curative effect and reducing side effect, and this medicine component is: diclofenac sodium, vitamin B
1, vitamin B
6, vitamin B
12, omeprazole, cimetidine, cyproheptadine hydrochloride, verapamil.
The formula of once taking of magistral medicines component of the present invention is: diclofenac sodium 50 ~ 70mg, vitamin B
120mg, vitamin B
620mg, vitamin B
120.05mg, omeprazole 10 ~ 20mg, cimetidine 0.2 ~ 0.4g, cyproheptadine hydrochloride 5 ~ 7mg, verapamil 40 ~ 60mg; Above-mentioned prescription medicine is simultaneously oral.
It is oral that the present invention makes powder after above-mentioned prescription medicine is adopted mixing again, or adopt powder oral above-mentioned prescription medicine; Take is 2-3 time on the one.
It is a course for the treatment of that the present invention takes 1-2 month.
The present invention is owing to combining known several drugs, and cooperate with each other reinforcement, mutually makes up, and defines a set of specially for the set boxing of cancer, concentrates Therapeutic cancer, have special curative effect.Because ingredient each in prescription all changes originally by the purposes extensively known, wherein belong to the diclofenac sodium of NSAID (non-steroidal anti-inflammatory drug) class medicine together, in the antiinflammatory of cancer, analgesia, refrigeration function much larger than the aspirin, indomethacin etc. that belong to NSAID (non-steroidal anti-inflammatory drug) class medicine together.Medically proved NSAID (non-steroidal anti-inflammatory drug) aspirin, antitumaous effect that indomethacin has, Aspirin can improve caused by radiation ulcer, diarrhoea and enterospasm, and can prevent Nasopharyngeal neoplasms, improves immunologic function, suppress little tumor growth, and strengthen the effect of anticarcinogen.Control (pulmonary carcinoma, rectal cancer, gastric cancer and skin carcinoma) aspirin, diclofenac sodium improving immunocompetence in solid carcinoma auxiliary, improve radiotherapy chemotherapy effect, and the transfer of cancerous protuberance can be prevented.The diclofenac sodium being all NSAID (non-steroidal anti-inflammatory drug) has broad-spectrum anti-tumor effect too, can the generation of Tumor suppression, growth and transfer, and have synergism with radiotherapy, chemotherapy.In fact, in NSAID (non-steroidal anti-inflammatory drug), the effect of diclofenac sodium is stronger, not only have antitumaous effect, and performance is more superior.
Vitamin B
6: former is nutrition tonic, and for anticancer in formula of the present invention, its effect played is:
Vitamin B
6anticancer efficacy and phosphinothioylidynetrisaziridine similar, and enhancing human body immunity function, can combined with chemotherapy, radiotherapy effect.Megavitamin B
6breast carcinoma and bladder cancer (minimizing carcinogen) can be prevented and treated.
Cyproheptadine hydrochloride: antiallergic agent, herein for anticancer.The effect played of cyproheptadine hydrochloride is:
1. cyproheptadine hydrochloride 12mg/d divides three clothes, tumour regression, diminishes, and symptom is obviously improved.
2. cyproheptadine hydrochloride 0.5 ~ 4mg/d, has mitigation to bladder cancer, pulmonary carcinoma, breast carcinoma and adrenocortical tumor, and the multidrug resistance of reversible tumor cell.
3. carcinoid Intra operative complica-tions is prevented.Preoperative 24h oral hydrochloride Cyproheptadine.
4. because the cause of death overwhelming majority of cancer patient is that anorexia causes, and cyproheptadine hydrochloride is the active drug increasing appetite, effective to apositia, therefore can increase appetite to cancer patient, extending life.
Cimetidine: gastric ulcer resistance medicine, herein for antitumor, especially grows the tumor at stomach, can Tumor suppression growth and enhancing immunity.The effect played of cimetidine is:
1. in treatment gastric cancer: cimetidine 0.2g, takes at twice on the 1st, 2 years courses for the treatment of, can extend life cycle, also can improve the partial symptoms of carcinoid syndrome patient.
2. the terminal cancer such as lung cancer metastasis: cimetidine 0.3g twice on the mono-is oral, and focus can be made obviously to reduce, and cimetidine 0.2g ~ 0.4g is oral, once a day, adds aspirin for treatment several late cancers, effective percentage 81%, and mean survival time (MST) obviously extends.
3. oral cimetidine 0.2g once a day, has suppression malignant growth, delays transcellular effect.
4. melanoma: cimetidine 1g/d and interferon 400 ~ 1,200 ten thousand μ/d or take dicoumarol 100mg, adds after 15 days with cimetidine 300mg every day 4 times, can make tumor regression, drug withdrawal when being obviously in progress to disease.
5. hematological system tumor: cimetidine 1.2g is oral, 28 days courses for the treatment of, treats chronic bone-marrow-derived lymphocyte leukemia, T lymphocyte cancer all obtains clinical remission, but easily recur after drug withdrawal.Cimetidine also can improve the partial symptoms of alkaline leukemia, the true erythrocytosis person of Hodgkin machine.
6. ovarian cancer: oral cimetidine 1g/d, the natural killer cell activity of patient can be improved, strengthen antitumor immunity (mechanism: the inhibitory action eliminating histamine, strengthen antibody synthesis, antiinflammatory and reconstituted cell immunization, and accelerate the removing of antigen) cimetidine also can stop erethistic ulcer to be formed, and also has positive role to the control of immune-complex disease (ICD).
7. various cancer pain at late stage: 3 ~ 10 weeks courses for the treatment of of cimetidine 1 ~ 2g/d.Coupling NSAID (non-steroidal anti-inflammatory drug) (aspirin, diclofenac sodium etc.), has certain effect to alleviating pain anorexia, abdominal distention, cachexia etc.
Verapamil: anti-arrhythmic, herein for antitumor.The effect played of verapamil is:
Verapamil can Tumor suppression growth, the Blood route metastasis of prevention cancerous cell, the drug toxicity of reduction anticarcinogen and the cytotoxicity of enhancing cancer therapy drug.In verapamil T suppression cell, anticarcinogen (mitomycin, vinblastine, vincristine, etoposide, amycin etc.) outflow, can make anticancer chemotherapeutic agent concentration in cell significantly improve, and can overcome the drug resistance of tumor, improves therapeutic effect.
Interaction in this prescription between each medicine:
1, verapamil can strengthen antiinflammatory, the analgesic activity of NSAID (non-steroidal anti-inflammatory drug) (indomethacin, diclofenac sodium).
2, oral vitamin B
6when heavy dose, there is more weak analgesic effect, vitamin B
1and vitamin B
6coupling has stronger analgesic effect, and has good dose-effect relationship.Vitamin B
12vitamin B can be strengthened
1and vitamin B
6the analgesic effect of coupling, alleviating pain.Vitamin B
6the analgesic effect of nonsteroidal antiinflammatory drug can also be strengthened.
3, cimetidine can suppress verapamil metabolism, improves bioavailability, haemoconcentration is raised, two medicine couplings (can suitably reduce verapamil consumption).
4, H
2receptor antagonist (cimetidine etc.) and H
1receptor antagonist (diphenhydramine, Cyproheptadine etc.) coupling can strengthen irritated curative effect, comprehensively retardance histamine effect.
5, omeprazole can prevent the gastric injury of NSAID (non-steroidal anti-inflammatory drug) (aspirin, indomethacin, diclofenac sodium etc.).
6, antihistaminic (Cyproheptadine) can eliminate some side effect of NSAID (non-steroidal anti-inflammatory drug) (indomethacin, diclofenac sodium etc.).
7, cimetidine can prevent the gastric injury of NSAID (non-steroidal anti-inflammatory drug) (aspirin, indomethacin, diclofenac sodium etc.), but can reduce absorption and reduce drug effect.
8, omeprazole can affect vitamin B
12absorb, the vitamin B caused
12(coupling suitably can increase vitamin B to shortage
12consumption).
The present invention is as follows with the interaction of cancer therapy drug conventional at present:
(1) NSAID (non-steroidal anti-inflammatory drug) (indomethacin, diclofenac sodium etc.) and fluorouracil coupling, cellular immune function recovers very fast.
(2) NSAID (non-steroidal anti-inflammatory drug) (aspirin, indomethacin, diclofenac sodium etc.) and methotrexate coupling, its haemoconcentration obviously increases, and curative effect and toxicity all increase.
(3) cimetidine and cyclophosphamide coupling or be used alternatingly, scalable T cell is active, reduces drug resistance and serious toxicity.
(4) anticarcinogen (mitomycin, vinblastine, vincristine, etoposide, amycin etc.) outflow in verapamil T suppression cell, anticancer chemotherapeutic agent concentration in cell can be made to significantly improve, and the drug resistance of tumor can be overcome, improve chemotherapy effect.
(5) vitamin B
6colchicine toxic and side effects can be alleviated, and cyclophosphamide can be alleviated to liver, intestinal side effect.
(6) antineoplastic agent can weaken vitamin B
12anti-anemia action effect, and can vitamin B be reduced
12absorption.
In prescription of the present invention, diclofenac sodium, vitamin B
1, vitamin B
6, vitamin B
12, omeprazole, cimetidine, cyproheptadine hydrochloride, each component of verapamil work in coordination with mutually, mutually promotes, comprehensive, Mutiple Targets controls the generation of tumor cell, development, transfer, and the state of an illness is eased.
Medicine of the present invention has following therapeutic effect:
1, medicine of the present invention can the development of comprehensive, Mutiple Targets Tumor suppression and transfer, anticarcinogen (mitomycin, vinblastine, vincristine, etoposide, amycin etc.) outflow in T suppression cell, make cell internalizing treat medicine to significantly improve, overcome the drug resistance of tumor, stop cancerous cell Blood route metastasis, reduce chemotherapeutic toxicity.
2, this medicine has broad-spectrum anti-tumor effect, and tumor regression can be made to degenerate, and symptom is obviously improved.Intestinal cancer takes this prescription can make the incidence rate of colon and rectum carcinoma and mortality rate reduce by more than 50%.Have good mitigation to hepatocarcinoma, bladder cancer, pulmonary carcinoma, cancer of pancreas, breast carcinoma, esophageal carcinoma, life cycle obviously extends, and quality of life significantly improves.
3, prevent cancer patient from generating heat.The heating of the present invention to various cancer has refrigeration function.
4, pain relieving of cancers: this prescription has comparatively ideal analgesic effect to multiple cancer pain, can replace the antalgica such as morphine, dolantin and without additive.
5, radiotherapy, chemotherapy effect is improved.Strengthen anticarcinogen curative effect, have synergism with radiotherapy chemotherapy, reduce chemotherapeutic consumption and harm.
6, immunologic function is improved, health invigorating.Make the fast quick-recovery of immunologic function that radiotherapy, chemotherapy are impaired.
7, the generation of prophylaxis of cancer.Good preventive effect is had to kinds cancer.Wherein the incidence rate of the esophageal carcinoma, gastric cancer, colon and rectum carcinoma, ovarian cancer reduces by more than 50%.
8, this prescription of perioperatively, can prevent intraoperative compliaction and postoperative secondary cancer.。
9, the death that cancer patient causes because of anorexia is significantly reduced.This prescription can appetite strengthening, treatment anorexia, effective percentage 91%.
10, comparatively ideal curative effect is had to the aseptic inflammation or carcinoid syndrome etc. that are misdiagnosed as cancer.
Detailed description of the invention
A kind of broad spectrum anticancer anti-cancer magistral medicines, the present invention is characterised in that, this medicine component is: diclofenac sodium, vitamin B
6, cimetidine, cyproheptadine hydrochloride, verapamil.
The formula once taken of magistral medicines component of the present invention is: diclofenac sodium 50 ~ 70mg, vitamin B
620mg, cimetidine 0.2 ~ 0.4g, cyproheptadine hydrochloride 5 ~ 7mg, verapamil 40 ~ 60mg; Above-mentioned prescription medicine is simultaneously oral.
The present invention is for improving curative effect and reducing side effect, and this medicine component is: diclofenac sodium, vitamin B
1, vitamin B
6, vitamin B
12, omeprazole, cimetidine, cyproheptadine hydrochloride, verapamil.
The formula of once taking of magistral medicines component of the present invention is: diclofenac sodium 50 ~ 70mg, vitamin B
120mg, vitamin B
620mg, vitamin B
120.05mg, omeprazole 10 ~ 20mg, cimetidine 0.2 ~ 0.4g, cyproheptadine hydrochloride 5 ~ 7mg, verapamil 40 ~ 60mg; Above-mentioned prescription medicine is simultaneously oral.
It is oral that the present invention makes powder after above-mentioned prescription medicine is adopted mixing again, or adopt powder oral above-mentioned prescription medicine; Take is 2-3 time on the one.
It is a course for the treatment of that the present invention takes 1-2 month.
Embodiment one
By the formula of once taking of medicine component be: diclofenac sodium 65mg, vitamin B
620mg, cimetidine 0.3g, cyproheptadine hydrochloride 6mg, verapamil 60mg; Above-mentioned prescription medicine is simultaneously oral.
Embodiment two
By the formula of once taking of medicine component be: diclofenac sodium 65mg, vitamin B
120mg, vitamin B
620mg, vitamin B
120.05mg, omeprazole 15mg, cimetidine 0.3g, cyproheptadine hydrochloride 6mg, verapamil 60mg; Above-mentioned prescription medicine is simultaneously oral.
Embodiment three
By the formula of once taking of medicine component be: diclofenac sodium 50mg, vitamin B
620mg, cimetidine 0.3g, cyproheptadine hydrochloride 7mg, verapamil 40mg; Above-mentioned prescription medicine is simultaneously oral.
Embodiment four
By the formula of once taking of medicine component be: diclofenac sodium 55mg, vitamin B
120mg, vitamin B
620mg, vitamin B
120.05mg, omeprazole 20mg, cimetidine 0.3g, cyproheptadine hydrochloride 6mg, verapamil 55mg; Above-mentioned prescription medicine is simultaneously oral.
Embodiment five
By the formula of once taking of medicine component be: diclofenac sodium 70mg, vitamin B
120mg, vitamin B
620mg, vitamin B
120.05mg, omeprazole 10mg, cimetidine 0.3g, cyproheptadine hydrochloride 5mg, verapamil 40mg; Above-mentioned prescription medicine is simultaneously oral.
Embodiment six
By the formula of once taking of medicine component be: diclofenac sodium 60mg, vitamin B
120mg, vitamin B
620mg, vitamin B
120.05mg, omeprazole 18mg, cimetidine 0.3g, cyproheptadine hydrochloride 6mg, verapamil 50mg; Above-mentioned prescription medicine is simultaneously oral.
Model case is as follows:
Chen man 53 years old, on April 10th, 2015, family members said that patient suffers from hepatocarcinoma and hardened ascites late period, then in 10 days April in 2015, took magistral medicines of the present invention, after taking medicine 10 days, pain relief, abdominal distention disappear take off, appetite increase, symptom be clearly better.The enough bimestrial magistral medicines of the present invention of phone call again.
Zhu female suffers from hepatocarcinoma, through in October, 2012 excision, after adhere to taking magistral medicines of the present invention, do not recur so far.
Female Korea Spro throat pain, dysphagia are epithelium of esophagus cancer through hospital diagnosis, start to take magistral medicines of the present invention with at the beginning of 2015 5 months, and after taking medicine 10 days, pain disappears, and swallow smoothly; Now adhere to taking magistral medicines of the present invention.
Grandson female is gastric cancer through hospital diagnosis in May, 2013, and its lump is 2.5 × 3.5 ㎝, vomit duo to chemotherapy, anorexia, and in October, 2013 starts to take magistral medicines of the present invention upon somebody's introduction, and after taking medicine about two weeks, symptom alleviates, and condition is greatly improved; In August, 2014 checks, and lump is 1.5 × 2 ㎝, and still adhere to so far taking magistral medicines of the present invention, tumor does not shift, and the state of an illness does not worsen.
Land man 51 years old sufferers themselves is a doctor.Feeling cough, dyspnea in May, 2014, is lung carcinoid through hospital diagnosis.Take medicine, have an injection all invalid, the state of an illness increases the weight of increasingly.Take magistral medicines of the present invention after being introduced, the state of an illness slowly alleviates.So far the state of an illness recovers normal substantially, but adheres to taking magistral medicines of the present invention always.
Also there is many cases in above-mentioned situation, does not repeat one by one at this.
Claims (6)
1. a broad spectrum anticancer anti-cancer magistral medicines, it is characterized in that, this medicine component is: diclofenac sodium, vitamin B
6, cimetidine, cyproheptadine hydrochloride, verapamil.
2. a kind of broad spectrum anticancer anti-cancer magistral medicines according to claim 1, it is characterized in that, the formula once taken of this medicine component is: diclofenac sodium 50 ~ 70mg, vitamin B
620mg, cimetidine 0.2 ~ 0.4g, cyproheptadine hydrochloride 5 ~ 7mg, verapamil 40 ~ 60mg; Above-mentioned prescription medicine is simultaneously oral.
3. a kind of broad spectrum anticancer anti-cancer magistral medicines according to claim 1, it is characterized in that, for improving curative effect and reducing side effect, this medicine component is: diclofenac sodium, vitamin B
1, vitamin B
6, vitamin B
12, omeprazole, cimetidine, cyproheptadine hydrochloride, verapamil.
4. a kind of broad spectrum anticancer anti-cancer magistral medicines according to claim 3, it is characterized in that, the formula of once taking of this medicine component is: diclofenac sodium 50 ~ 70mg, vitamin B
120mg, vitamin B
620mg, vitamin B
120.05mg, omeprazole 10 ~ 20mg, cimetidine 0.2 ~ 0.4g, cyproheptadine hydrochloride 5 ~ 7mg, verapamil 40 ~ 60mg; Above-mentioned prescription medicine is simultaneously oral.
5. a kind of broad spectrum anticancer anti-cancer magistral medicines according to claim 2 or 4, is characterized in that, make powder oral after above-mentioned prescription medicine being adopted mixing again, or adopt powder oral above-mentioned prescription medicine; Take is 2-3 time on the one.
6. a kind of broad spectrum anticancer anti-cancer magistral medicines according to claim 1 or 4 or 5, it is characterized in that, taking 1-2 month is a course for the treatment of.
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|---|---|---|---|
| CN201510287646.7A CN104887672A (en) | 2015-05-29 | 2015-05-29 | Broad-spectrum anticancer and cancer prevention formula medicine |
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|---|---|---|---|
| CN201510287646.7A CN104887672A (en) | 2015-05-29 | 2015-05-29 | Broad-spectrum anticancer and cancer prevention formula medicine |
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| CN104887672A true CN104887672A (en) | 2015-09-09 |
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ID=54020918
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107536886A (en) * | 2017-09-11 | 2018-01-05 | 晁伟岩 | Broad spectrum anticancer compound medicine |
-
2015
- 2015-05-29 CN CN201510287646.7A patent/CN104887672A/en active Pending
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107536886A (en) * | 2017-09-11 | 2018-01-05 | 晁伟岩 | Broad spectrum anticancer compound medicine |
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Application publication date: 20150909 |
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