CN104887658B - Acetylcholine or acetylcholinesteraseinhibitors inhibitors are preparing the purposes in treating fetus low blood pressure medicine - Google Patents
Acetylcholine or acetylcholinesteraseinhibitors inhibitors are preparing the purposes in treating fetus low blood pressure medicine Download PDFInfo
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- CN104887658B CN104887658B CN201510250598.4A CN201510250598A CN104887658B CN 104887658 B CN104887658 B CN 104887658B CN 201510250598 A CN201510250598 A CN 201510250598A CN 104887658 B CN104887658 B CN 104887658B
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Abstract
The invention belongs to biomedical sector, and the invention discloses the medicinal usage of acetylcholine or acetylcholinesteraseinhibitors inhibitors in fetus low blood pressure is treated.Present invention intravenous injection ACh monitoring blood pressures find that ACh can slightly improve fetal blood pressure and heart function.Therefore, this patent is directed to ACh new applications, i.e. by ACh be applied to treatment in utero the fetus low blood pressure caused by poor environment with this improve fetus antioxygen therapy, reduce fetus each organ damage caused by anoxic.The direct transformation ACh of curative effect exploitation and the novel drugs of internal ACh contents are improved indirectly will be expected to slow down fetal distress in uterus, improve healthy newborn birth rate accordingly.
Description
Technical field
The invention belongs to biomedical sector, is related to the medicinal usage of acetylcholine or acetylcholinesteraseinhibitors inhibitors, special
It is not the medicinal usage for being related to acetylcholine or acetylcholinesteraseinhibitors inhibitors in fetus low blood pressure is treated.
Background technology
Acetylcholine（acetylcholine；ACh）Be by choline and acetyl coenzyme A choline acetyl translocase catalysis
A kind of common neurotransmitter of the lower synthesis of effect, nerve conduction is participated in autonomic nerves system and somatic motor nerve system.
On the other hand, ACh also has important influence to cardiovascular system, and it is by excitement and combines cholinergic recepter, activates downstream
Path, cause periphery, maincenter vasodilation；Also sinoatrial node, which can be acted on, causes decreased heart rate, myocardial contractive power decrease, atrial refractory
Phase shortens.It is less as clinical because acetylcholine is easily decomposed and influence effect rapidly by acetylcholinesterase in tissue
It is medicinal.
The antenatal bad uterine environment of pregnant woman, such as the hypertension of pregnancy, heart failure, anemia, cord around neck and production
Journey is long to cause fetus blood supply oxygen supply deficiency, produces the growth retardation of fetus even serious consequence of foetal death.Currently for tire
The poverty-stricken treatment of youngster based on expectant treatment, mainly adjusts pregnant woman's condition improvement in utero with rescue method by regular antenatal exaination
Development of fetus damages caused by the method for fetal state or timely row Cesarean esction reduces anoxic as far as possible.
The content of the invention
Technical problems to be solved：The present invention specify that acetylcholine in fetus low blood pressure is treated by experimental study
Effect, and then propose acetylcholine be used for prepare treat fetus low blood pressure medicine in purposes.
Technical scheme：Acetylcholine or acetylcholinesteraseinhibitors inhibitors are preparing the use in treating fetus low blood pressure medicine
On the way.
Preferably, described acetylcholine or acetylcholinesteraseinhibitors inhibitors are in treatment fetus low blood pressure medicine is prepared
Purposes, triggering the inducement of fetus low blood pressure includes：
A. the small cerebral arterial insufficiency caused by hypertension, ephritis or gestation hypertension；
B. anemia, heart disease Burnout or red blood cell oxygen carrying content deficiency caused by pulmonary heart disease；
C. acute bleeding caused by ante partum hemorrhage disease or wound；
D. precipitate labor or uterine incoordination shrink；Oxytocins improper use, cause too strong uterine contraction；Prolonged labor；Uterus mistake
Degree expansion；Premature rupture of fetal membranes, umbilical cord may be pressurized caused by placenta uterina blood fortune be obstructed；
E. fetus blood supply insufficiency caused by cord around neck；
F. pregnant woman enters highlands, fetal anoxia caused by pregnant woman's oxygen absorbed declines.
It is further preferred that described acetylcholine or acetylcholinesteraseinhibitors inhibitors is preparing treatment fetus low blood pressure medicine
Purposes in thing, described prolonged labor are prolonged second stage of labor.
Preferably, described acetylcholine or acetylcholinesteraseinhibitors inhibitors are in treatment fetus low blood pressure medicine is prepared
Purposes, described medicine are administered by intravenous route or oral cavity route.
Preferably, described acetylcholine or acetylcholinesteraseinhibitors inhibitors are in treatment fetus low blood pressure medicine is prepared
Purposes, the dosage form of described medicine include liquid preparation, granule, sustained release agent, impact, tablet or capsule.
Preferably, described acetylcholine or acetylcholinesteraseinhibitors inhibitors are in treatment fetus low blood pressure medicine is prepared
Purposes, percentage by weight of the acetylcholine in medicine are 0.1wt%-99.9wt%.
It is further preferred that described acetylcholine or acetylcholinesteraseinhibitors inhibitors is preparing treatment fetus low blood pressure medicine
Purposes in thing, percentage by weight of the acetylcholine in medicine are 1wt%-99wt%.
Preferably, described acetylcholine or acetylcholinesteraseinhibitors inhibitors are in treatment fetus low blood pressure medicine is prepared
Purposes, described acetylcholinesteraseinhibitors inhibitors include neostigmine, Tacrine and its derivative, donepezil, kappa Latin,
Galanthamine or huperzine.
Beneficial effect：Inventor has found that although ACh can cause periphery and maincenter vasodilation, vein through zoopery
Injection ACh monitoring blood pressures find that ACh can slightly improve fetal blood pressure and heart function.Therefore, it is new to be directed to ACh for this patent
Purposes, i.e. by ACh be applied to treatment in utero the fetus low blood pressure caused by poor environment with this improve fetus antioxygen therapy,
Reduce fetus each organ damage caused by anoxic.Accordingly the direct transformation ACh of curative effect exploitation and internal ACh is improved indirectly contain
The novel drugs of amount will be expected to slow down fetal distress in uterus, improve healthy newborn birth rate.
Brief description of the drawings
Fig. 1 is influence figures of the ACh to pregnancy period fetal blood pressure.
Embodiment
ACh intravenous injections improve fetal blood pressure：Sheep model, 10.
ACh is prepared：Calculated by 40 μ g of every kg tires sheep administration and weigh required ACh mass, be dissolved in 1mL sterile water for injection
In, filtration sterilization is now with the current.
ACh is administered：Tire sheep is performed a surgical operation, after separating femoral artery and being intubated, ACh solution is given by transcatheter arterial
1mL, and with 2.5mL heparinized saline tube sealings.
Inventor is clear-headed to the application of pregnant sheep, and without stress situation, in utero detection technique, dynamic detection are performed the operation straight by arterial cannulation
Fetal blood pressure changes before and after meeting injection ACh, and as shown in Figure 1, tire sheep basic blood pressure is 52 mmHg, is injected intravenously 160 μ g ACh
（40 μ g ACh, which are injected, according to every kg body weight calculates solution of the 4kg tires sheep injection 1mL containing 160 μ g ACh）Afterwards, blood pressure rises rapidly
To 56 mmHg, 10 minutes or so actual blood pressure increasing state duration, heart rate is most slightly to be raised.
The research of inventor shows that ACh shows consistent reaction to fetal blood pressure variation tendency（Refer to form 1）, prompt
ACh improves the positive effect of fetal blood pressure and stablized.
Blood pressure and changes in heart rate before and after the fetal AC h of table 1 administrations
| Mean blood pressure（mmHg） | Heart rate (BPM) | |
| Before ACh administrations | 52.73±2.47 | 153.99±19.18 |
| * after ACh administrations | 57.10±3.14 | 156.60±13.06 |
| P values | 0.002 | 0.205 |
* the blood pressure steadily kept after being administered.
Claims (1)
1. acetylcholine is preparing the purposes in treating fetus low blood pressure medicine, it is characterised in that triggers luring for fetus low blood pressure
Because including：
A. the small cerebral arterial insufficiency caused by hypertension, ephritis；
B. anemia, heart disease Burnout or red blood cell oxygen carrying content deficiency caused by pulmonary heart disease；
C. acute bleeding caused by ante partum hemorrhage disease or wound；
D. precipitate labor or uterine incoordination shrink；Oxytocins improper use, cause too strong uterine contraction；Prolonged labor；Uterus is excessively swollen
It is swollen；Premature rupture of fetal membranes, umbilical cord may be pressurized caused by placenta uterina blood fortune be obstructed；
E. fetus blood supply insufficiency caused by cord around neck；
F. pregnant woman enters highlands, fetal anoxia caused by pregnant woman's oxygen absorbed declines；
Described prolonged labor is prolonged second stage of labor；
Described medicine is administered by intravenous route or oral cavity route；
The dosage form of described medicine is liquid preparation, granule, sustained release agent, electuary, tablet or capsule；
Percentage by weight of the acetylcholine in medicine is 1wt%-99wt%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510250598.4A CN104887658B (en) | 2015-05-18 | 2015-05-18 | Acetylcholine or acetylcholinesteraseinhibitors inhibitors are preparing the purposes in treating fetus low blood pressure medicine |
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|---|---|---|---|
| CN201510250598.4A CN104887658B (en) | 2015-05-18 | 2015-05-18 | Acetylcholine or acetylcholinesteraseinhibitors inhibitors are preparing the purposes in treating fetus low blood pressure medicine |
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| CN104887658A CN104887658A (en) | 2015-09-09 |
| CN104887658B true CN104887658B (en) | 2017-12-08 |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114391821B (en) * | 2021-12-28 | 2023-09-22 | 张雨萌 | Monitor for automatically converting heart rate and blood pressure of fetus in intrauterine hypoxia detection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014136075A1 (en) * | 2013-03-06 | 2014-09-12 | Richter Gedeon Nyrt. | H3 antagonists containing phenoxypiperidine core structure |
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2015
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014136075A1 (en) * | 2013-03-06 | 2014-09-12 | Richter Gedeon Nyrt. | H3 antagonists containing phenoxypiperidine core structure |
Non-Patent Citations (2)
| Title |
|---|
| 去甲肾上腺素与乙酰胆碱对家兔动脉血压影响的量效研究;刘红 等;《现代医药卫生》;20111231;第27卷(第3期);第322-323页 * |
| 硝普钠造成狗低血压时脑内注射东莨菪碱对电针升压作用的影响;肖永福 等;《生理学报》;19851231;第37卷(第1期);第31-36页 * |
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Granted publication date: 20171208 Termination date: 20210518 |