CN104874034B - A kind of adsorption tanks and the adsorption tanks with microneedle array - Google Patents
A kind of adsorption tanks and the adsorption tanks with microneedle array Download PDFInfo
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- CN104874034B CN104874034B CN201510291445.4A CN201510291445A CN104874034B CN 104874034 B CN104874034 B CN 104874034B CN 201510291445 A CN201510291445 A CN 201510291445A CN 104874034 B CN104874034 B CN 104874034B
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- CN
- China
- Prior art keywords
- microneedle array
- adsorption tanks
- tank body
- skin
- check valve
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Abstract
The present invention relates to being used as medicine technique with the apparatus field by skin, disclose a kind of adsorption tanks, including the tank body of lower openings, tank body top be provided with for connect outside air-extractor tubulose bleeding point, the joint for installing microneedle array；Its center tap is fixed in tank body, and bleeding point interior sealing is assembled with check valve.The present invention is when using, the microneedle array storing medicine is stretched in adsorption tanks and is affixed on joint, then the opening of adsorption tanks is fitted to skin surface, it is pumped into negative pressure with outside air-extractor by adsorption tanks, make local skin raised, adsorption tanks tightly adsorb in skin surface, so that the skin of projection is fitted tightly with microneedle array simultaneously, micropin punctures skin, makes medicine enter human body and realizes percutaneous dosing.Solve the problems, such as that microneedle array of the prior art is difficult skin of fitting, the skin relaxing especially for old people, effect becomes apparent from.
Description
Technical field
The present invention relates to being used as medicine technique with the apparatus field by skin, more particularly to a kind of adsorption tanks and band micropin battle array
The adsorption tanks of row.
Background technology
On current medical science and technology field, with the development of microelectric technique, various micro- doctor's electricity products arise at the historic moment.For reality
Existing painless, efficient, rapidly by drug delivery to internal, Prausnitz professor's research group of the U.S. in 1998 proposes first
Miniature solid silicon pin array prepared by application microelectron-mechanical Technology (MEMS) can be used for percutaneous dosing.Thus, micropin
Administration causes extensive attention.Compared with convenient administration, micropin administration can be realized stablizing and controlled injection speed, efficiently,
Painless and noninvasive or minimally invasive, and can be with patient's self-medication.
Additionally, microneedle array can be used for the detection of bioelectrical signals, using metal micro-needle array or other microneedle array table
Face is crossed multiple layer metal material and is realized.
Material for making microneedle array is mainly metal, monocrystal silicon and three kinds of polymer.Monocrystal silicon microneedle array is crisp
Property is larger, leads to micropin to be easily broken off.Polymer micro needle array insufficient strength is big, is difficult to pierce horny layer.Metal micro-needle array
Develop to obtain comparative maturity, safety also has certain guarantee.But these three microneedle arrays all have the shortcomings that one common, that is,
It is difficult skin of fitting, easily come off, the skin relaxing especially for old people, laminating skin effects are poor, are unfavorable for medicine
Infiltration and absorption.
The cup of the traditional Chinese medical science is to cause negative pressure in tank by aerofluxuss, enables tank body to be adhere tightly to skin surface, tractive
Nerve, muscle, blood vessel and subcutaneous body of gland, can cause a series of neuroendocrine responses, adjust blood vessel relax, contracting function and blood
The permeability of pipe is thus improve local blood circulation.The suction function of cup makes local hyperemia, congestion rapidly, and little blood capillary is very
To rupture, hematoclasis, there are haemolysises.In erythrocyte, the release of hemoglobin is a kind of optimal stimulation to body, it
Two-ways regulation can be carried out to the function of histoorgan by nervous system, simultaneously facilitate the phagocytosiss of leukocyte, improve skin
The sensitivity changing to external world and tolerance, thus the immunity of enhancing body.Secondly, the powerful power of pulling of negative pressure can make fine hair
Hole is fully opened, and the function of sweat gland and sebaceous gland is upset and strengthens, and skin surface senile cell comes off, from but make internal
Toxin, waste be able to Accelerating Removal.The change of vascular tone and mucosa penetration at cup, lymph circulation accelerates, phagocytosis
Effect is strengthened, and to infectious lesionses, undoubtedly defines the good environment of a biological resistance cause of disease.In addition, haemolysises is slow
Sexual stimuluses play health care to human body.
Can inventor consider in conjunction with Chinese medicine cup and the modern respective advantage of microneedle array, and produce unexpected effect
Fruit is improving the laminating effect to skin for the microneedle array.
Content of the invention
The present invention is to overcome above-mentioned deficiency of the prior art, there is provided a kind of adsorption tanks being favorably improved laminating effect
And the adsorption tanks with microneedle array.
The present invention is achieved through the following technical solutions above-mentioned purpose.
A kind of adsorption tanks, including the tank body of lower openings, tank body top is provided with the tubulose for connecting outside air-extractor
Bleeding point, the joint for installing microneedle array；Its center tap is fixed in tank body, and bleeding point interior sealing is assembled with check valve.
This programme, when using, the microneedle array storing medicine is stretched in adsorption tanks and is affixed on joint,
Then the opening of adsorption tanks is fitted to skin surface, be pumped into negative pressure with outside air-extractor by adsorption tanks, make local skin
Projection, adsorption tanks tightly adsorb in skin surface, so that the skin of projection is fitted tightly with microneedle array, micropin punctures skin simultaneously
Skin, makes medicine enter human body and realizes percutaneous dosing.Solve the problems, such as that microneedle array of the prior art is difficult skin of fitting, especially
It is the skin relaxing for old people, and effect becomes apparent from.After forming negative pressure in adsorption tanks, skin surface forms local simultaneously
Congestion, topical blood flow speed is accelerated, and in conjunction with microneedle array administration, is more beneficial for infiltration and the absorption of medicine.In the traditional Chinese medical science
Cup is difficult to realize the purpose of percutaneous dosing.The inventor of this programme cleverly combines in the case of not having any related Revelation
Chinese medicine cup technology and modern microneedle array technology respective feature, the effect of acquirement exceeds the effect that respective technology is individually implemented
Really, compared with prior art have and significantly improve.
Above-mentioned bleeding point and joint can misplace arrangement it is also possible to coaxially arranged.Tank body be usually adopt glass or
The rotary body that potter's clay is fired, for the ease of making tank body, prioritization scheme is using coaxially arranged bleeding point and joint.Specifically
Scheme is to fix an annular solid in bleeding point lower end, with bleeding point inner seal outside annular solid, annular solid is communicated with tank
The aperture of inside and outside；Joint is tubular configured joint, tubular configured joint be fixed on annular solid and tubular configured joint outer ring and annular solid inside
Sealing, the suitable for reading of tubular configured joint is sealed with top board；Above-mentioned check valve is located at the top of annular solid and top board.This structure can contract
The volume of little tank body, reduces rate of air sucked in required, facilitates air suction process, simultaneously facilitate making tank body, clever structure is reasonable.Annular solid, connect
Head, top board can realize fixing seal by way of glue is adhesively fixed, it would however also be possible to employ alternate manner fixing seal.
For spherical shell and lower openings are circular open to above-mentioned tank body.Tank body is typically fired using glass or potter's clay
Rotary body, spherical shell structure is easy to the processing and fabricating of tank body；Circular open is easy to skin surface of fitting, and so that tank body is born
Pressure is difficult gas leakage after adsorbing on skin.
Micropin punctures depth and tank interior negative pressure can be controlled to be adjusted by outside air-extractor, sees for convenience
Examine and puncture depth to control the action of outside air-extractor in tank body, above-mentioned tank body is transparent, for example transparent glass
Tank body.
The check valve that above-mentioned check valve is made for elastic rubber material, it is shaped as cylinder, and cylinder lower end is upper spill
Face, cylinder upper end is convex-shaped face, and column body is communicated with concave panel to the gap passage in convex-shaped face, gap under normal pressure
It is in closure state that passage relies on the elasticity of rubber itself.During pumping, the pressure below upper concave panel is more than above convex-shaped face
Pressure, under differential pressure action, upper spill faces out distributing deformation upwards, is conducive to the unlatching of gap passage, facilitates air suction process；
When not being evacuated, the pressure below upper concave panel is less than the pressure above convex-shaped face, and under differential pressure action, convex-shaped is inward-facing downwards
Extruding, makes gap passage close, and prevents gas leakage, keeps negative-pressure balancing in tank body.
A kind of adsorption tanks with microneedle array, including microneedle array and channel, using above-mentioned adsorption tanks, channel
Upper end is sealedly connected on joint, and microneedle array is sealedly connected on the lower end of channel.
The sealing in pumping of above-mentioned bleeding point is communicated with pump bowl, pump bowl and bleeding point can by screw thread or its
Its mode carries out sealing and fastens, and deposits in order to dismount；It is stamped sealing-plug when not being evacuated, to prevent gas leakage further, or
Foreign body is had to enter and damage check valve etc..
It is provided with drug storage pipe and grug transportation tube, drug storage pipe is connected by grug transportation tube with microneedle array, medicine in above-mentioned channel
Enter microneedle array from drug storage pipe through grug transportation tube to carry out percutaneous dosing.
Microneedle array, in addition to for percutaneous dosing, can be also used for the detection of bioelectrical signals, for bioelectrical signals
Detection when above-mentioned top board and channel etc. adopt following structures：On top board, conductor is set, conductor connects outer lead, outward
Portion's wire sealing runs through check valve and exposes to check valve；Setting inner lead in channel, inner lead turns on microneedle array
With the conductor on top board, thus bioelectrical signals are transferred to aftertreatment device, realize the detection of bioelectrical signals.
The present invention compared with prior art mainly has the advantages that：Negative pressure is pumped into by tank body by pump bowl,
Skin is subject to larger suction, so that the skin of protuberance is fitted tightly with microneedle array；Especially loose to old people skin
There is traction action, be conducive to the piercing of micropin；After forming negative pressure, skin surface forms local congestion, topical blood flow speed
Degree is accelerated, and in conjunction with microneedle array administration, is more beneficial for infiltration and the absorption of medicine.
Brief description
Fig. 1 is the overall structure diagram of the embodiment of the present invention one.
Fig. 2 is the cross-sectional view of tank body in the embodiment of the present invention one.
Fig. 3 is the cross-sectional view of check valve in the embodiment of the present invention one.
Fig. 4 is the structural representation after sealing-plug on Cap for tin body in the embodiment of the present invention one.
Fig. 5 is the structural representation of channel in the embodiment of the present invention one.
Fig. 6 is the structural representation when embodiment of the present invention one uses.
Fig. 7 is the cross-sectional view of tank body in the embodiment of the present invention two.
Specific embodiment
The present invention will be further described below in conjunction with the accompanying drawings.The explanation of being for illustration only property of accompanying drawing is it is impossible to be interpreted as to this
The restriction of patent.
For more succinct explanation embodiment, accompanying drawing or explanation in some well known to a person skilled in the art but with this
The incoherent parts of main contents of bright creation can omit.In addition for ease of statement, in accompanying drawing, some parts have
Omit, zoom in or out, but do not represent size or the entire infrastructure of actual product.
Embodiment one：
As shown in figure 1, a kind of adsorbing sphere with microneedle array, including spherical shell tank body 1, pump bowl 2, microneedle array 3
With channel 4.
As shown in Fig. 2 tank body 1 bottom has circular open, tank body 1 top is provided with takes out for the tubulose connecting pump bowl 2
QI KOU 11, bleeding point 11 lower end are adhesively fixed an annular solid 5, annular solid 5 outside and bleeding point 11 inner seal, on annular solid 5
It is communicated with the aperture 51 inside and outside tank body 1；Annular solid 5 inner seal is adhesively fixed a tubular configured joint 6, tubular configured joint 6 suitable for reading
It is sealed with top board 61；Bleeding point 11 interior sealing is assembled with check valve 7, and check valve 7 is located at the top of annular solid 5 and top board 61.
As depicted in figs. 1 and 2, the upper end of channel 4 seals and is threaded on tubular configured joint 6, and microneedle array 3 seals
And it is threaded in the lower end of channel 4.
Micropin punctures depth and tank body 1 internal negative pressure can be controlled to be adjusted by pump bowl 2, observes tank for convenience
Depth is punctured to control the action of pump bowl 2, the tank body 1 in the present embodiment adopts transparent glass tank body in body 1.
As shown in figure 3, the check valve that check valve 7 is made for elastic rubber material, its principal shape is cylinder, cylinder lower end
For upper concave panel 71, cylinder upper end is convex-shaped face 72, and column body is communicated with the seam that concave panel 71 arrives convex-shaped face 72
Gap passage 73, under normal pressure, gap passage 73 relies on the elasticity of rubber itself is in closure state.During pumping, upper concave panel 71 lower section
Pressure is more than the pressure of convex-shaped face 72 top, and under differential pressure action, the outwards distributing deformation upwards of upper concave panel 71, is conducive to stitching
The unlatching of gap passage 73, facilitates air suction process；When not being evacuated, the pressure of upper concave panel 71 lower section is less than convex-shaped face 72 top
Pressure, under differential pressure action, convex-shaped face 72 extrudes inwardly downward, so that gap passage 73 is closed, and prevents gas leakage, keeps negative in tank body 1
Flatten weighing apparatus.
Again as shown in figure 1, bleeding point 11 sealing in pumping is communicated with pump bowl 2, pump bowl 2 and bleeding point 11 can lead to
Cross screw thread or alternate manner carries out sealing and fastens, deposit in order to dismount.As shown in figure 4, after pumping terminates bleeding point 11
It is stamped sealing-plug 8, to prevent gas leakage further.
As shown in figure 5, being provided with drug storage pipe 41 and grug transportation tube 42 in channel 4 in the present embodiment, drug storage pipe 41 and micropin battle array
Row 3 are connected by grug transportation tube 42, and medicine enters microneedle array 3 to carry out percutaneous dosing from drug storage pipe 41 through grug transportation tube 42.
As shown in fig. 6, the present embodiment, when using, the opening of tank body 1 is fitted to skin surface, with pump bowl 2 by tank
It is pumped into negative pressure in body 1, makes local skin raised, tank body 1 tightly adsorbs in skin surface, make skin and the micropin battle array of projection simultaneously
Row 3 fit tightly, and micropin punctures skin, make medicine enter human body and realize percutaneous dosing.
Embodiment two：
Embodiment one is for percutaneous dosing, and the present embodiment is the detection for bioelectrical signals.So the present embodiment with
Embodiment one primary structure is identical, and difference is that top board 61 and channel 4 etc. adopt following structures：As shown in fig. 7, top board
On 61, conductor 62 is set, conductor 62 connects outer lead 63, outer lead 63 seals longitudinally through check valve 7 and exposes to list
To valve 7；Setting inner lead 43 in channel 4, inner lead 43 turns on the conductor 62 on microneedle array 3 and top board 61, thus
Bioelectrical signals are transferred to aftertreatment device, realize the detection of bioelectrical signals.
These are only two specific embodiments of the present invention, but the design concept of the present invention is not limited thereto, all utilizations
The insubstantial modifications that present inventive concept is made to the present invention, each fall within protection scope of the present invention.
Claims (6)
1. a kind of adsorption tanks with microneedle array, the tank body including microneedle array, channel and lower openings it is characterised in that
Described tank body top be provided with for connect outside air-extractor tubulose bleeding point, for installing the joint of microneedle array；Its
Center tap is fixed in tank body, and bleeding point interior sealing is assembled with check valve；
The upper end of described channel is sealedly connected on described joint, and described microneedle array is sealedly connected on channel
Lower end；
An annular solid is fixed in described bleeding point lower end, with bleeding point inner seal outside annular solid, annular solid is communicated with
Aperture inside and outside tank body；Described joint is tubular configured joint, and tubular configured joint is fixed on annular solid and tubular configured joint outer ring and ring
Body inner seal, the suitable for reading of tubular configured joint is sealed with top board；Described check valve is located at the top of annular solid and top board；
Described top board is provided with conductor, and conductor is connected with outer lead, and outer lead sealing runs through check valve and exposes to
Check valve；It is provided with inner lead, inner lead turns on the conductor on microneedle array and top board in described channel.
2. the adsorption tanks with microneedle array according to claim 1 it is characterised in that described tank body be spherical shell and
Lower openings are circular open.
3. the adsorption tanks with microneedle array according to claim 1 are it is characterised in that described tank body is transparent.
4. the adsorption tanks with microneedle array according to claim 1 are it is characterised in that described check valve is gum elastic
The check valve that material is made, it is shaped as cylinder, and cylinder lower end is upper concave panel, and cylinder upper end is convex-shaped face, column body
It is communicated with concave panel to the gap passage in convex-shaped face, under normal pressure, gap passage relies on the elasticity of rubber itself is in closed form
State.
5. the adsorption tanks with microneedle array according to claim 1 are it is characterised in that described bleeding point is close in pumping
Envelope is communicated with pump bowl, is stamped sealing-plug when not being evacuated.
6. the adsorption tanks with microneedle array according to claim 1 are it is characterised in that be provided with drug storage in described channel
Pipe and grug transportation tube, drug storage pipe is connected by grug transportation tube with described microneedle array.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510291445.4A CN104874034B (en) | 2015-06-01 | 2015-06-01 | A kind of adsorption tanks and the adsorption tanks with microneedle array |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510291445.4A CN104874034B (en) | 2015-06-01 | 2015-06-01 | A kind of adsorption tanks and the adsorption tanks with microneedle array |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104874034A CN104874034A (en) | 2015-09-02 |
| CN104874034B true CN104874034B (en) | 2017-03-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510291445.4A Active CN104874034B (en) | 2015-06-01 | 2015-06-01 | A kind of adsorption tanks and the adsorption tanks with microneedle array |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108814925A (en) * | 2018-05-16 | 2018-11-16 | 蚌埠市龙子湖区天鉴理疗服务部 | A kind of cupping for capableing of quick adsorption |
| CN115530835A (en) * | 2022-10-21 | 2022-12-30 | 吉林大学 | Electrode system suitable for intelligent artificial limb |
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| CN2203156Y (en) * | 1994-11-25 | 1995-07-12 | 吴培德 | Negative pressure medicine analgesic caldron |
| CN2369679Y (en) * | 1999-05-25 | 2000-03-22 | 赵云虎 | Multipurpose medical cup |
| CN201070445Y (en) * | 2006-12-27 | 2008-06-11 | 林瑞如 | Multifunctional cupping cup |
| CN202270206U (en) * | 2011-10-11 | 2012-06-13 | 朱广运 | Multifunctional cupping device |
| US8915894B1 (en) * | 2000-01-24 | 2014-12-23 | Meditech Development Incorporated | Vacuum cup for delivery of agents during vacuum treatment |
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|---|---|---|---|---|
| CN1236603A (en) * | 1998-05-21 | 1999-12-01 | 河北路德医疗器械有限公司 | Acupoint negative-pressure cupping electrode with infrared radiation plate, medicine, magnet and needle |
| CN2363697Y (en) * | 1998-12-04 | 2000-02-16 | 张波 | Vacuum acupuncture massage physiotherapy apparatus |
| CN2391602Y (en) * | 1999-10-29 | 2000-08-16 | 李彦兵 | Medical and health-care articles |
| CN2414777Y (en) * | 1999-12-14 | 2001-01-17 | 陈刚 | Transcutaneous medicine osmosis instrument |
| CN202027902U (en) * | 2011-04-19 | 2011-11-09 | 张光岩 | Multifunctional medicine moxibustion cup |
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2015
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2203156Y (en) * | 1994-11-25 | 1995-07-12 | 吴培德 | Negative pressure medicine analgesic caldron |
| CN2369679Y (en) * | 1999-05-25 | 2000-03-22 | 赵云虎 | Multipurpose medical cup |
| US8915894B1 (en) * | 2000-01-24 | 2014-12-23 | Meditech Development Incorporated | Vacuum cup for delivery of agents during vacuum treatment |
| CN201070445Y (en) * | 2006-12-27 | 2008-06-11 | 林瑞如 | Multifunctional cupping cup |
| CN202270206U (en) * | 2011-10-11 | 2012-06-13 | 朱广运 | Multifunctional cupping device |
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