CN104873306A - Artificial cochlea simulation neural remote measurement system and method - Google Patents
Artificial cochlea simulation neural remote measurement system and method Download PDFInfo
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- CN104873306A CN104873306A CN201510261140.9A CN201510261140A CN104873306A CN 104873306 A CN104873306 A CN 104873306A CN 201510261140 A CN201510261140 A CN 201510261140A CN 104873306 A CN104873306 A CN 104873306A
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Abstract
The invention discloses an artificial cochlea simulation neural remote measurement system and method. The system comprises a signal generator, a salinity test meter, a converter, a debugging box, a language processor and an implantation material, the signal generator is used for receiving synchronizing signals and outputting sine wave simulation neural signals, the input end is connected with the language processor, and the output end is connected with the converter; the salinity test meter is used for testing the brine water concentration of the placed implantation material; the converter is used for isolating saline water from the signal generator, the input end of the converter is connected with the signal generator, and the output end of the converter is placed in the saline water where the implantation material is located; the debugging box is used for converting commands sent from a computer into signals which can be accepted by the language processor, the input end of the debugging box is connected with the computer, and the output end of the debugging box is connected with the language processor. By means of the artificial cochlea simulation neural remote measurement system and method, the risk of artificial cochlea failure due to stimulation is reduced, the troubleshooting and debugging prior to implantation can be achieved, and the clinical research after the implantation is facilitated as well.
Description
Technical field
The present invention relates to artificial cochlea's technical field, particularly artificial cochlea's analog neuron telemetry system and method.
Background technology
Artificial cochlea is fast-developing, and be that the deafness patient of ten million severe and pole severe brings glad tidings, quality of at utmost making the life better, returns to the sound world.But artificial cochlea's equipment and technology requires high, the result of use of patient generally directly cannot be judged in art, and corresponding acous active degree, so we need to carry out testing in some arts in art, such as implant electrode impedance is measured, electricity irritation auditory brainstem response (EABR), cochleostapedial reflex, neural response telemetry (NRT) etc., objective evaluation implant electrode is in i-coch duty.Simultaneously because the age of implantation person is more and more less, what have even just implants cochlear implant after birth some months, for the patient of this part, they effectively cannot report the perception for sound, and therefore neural response telemetry can help doctor to confirm that the phonoreception of listening of patient is felt by the nerve signal size of bringing out.The threshold of reaction contributes to audition teacher and opens in tune machine process after surgery, to the judgement of the maximum comfortable threshold of implantation person (C value) and the threshold of audibility (T value), and especially those patient that cannot subjective cooperate with on one's own initiative and children's.
General NRT carries out in implantation or after implanting, if find the electrode stimulating problem that can not solve by debugging software method, so both can cause unnecessary injury to human body, and waste the artificial cochlea of a set of costliness simultaneously.
Summary of the invention
In view of this, the object of the invention is to propose a kind of artificial cochlea's analog neuron telemetry system and method, the stimulation reliability of effective raising artificial cochlea, before implantation electrode stimulating performance and implant and speech processor matching coordinative degree are detected effectively, for follow-up tune machine provides valid data, improve uncomfortable nerve stimulation.
Based on above-mentioned purpose a kind of artificial cochlea's analog neuron telemetry system provided by the invention, comprise signal generator, salinity test chart, transducer, debugging box, speech processor, implant, wherein,
Described signal generator, for receiving synchronizing signal, sine wave output analog neuron signal, input is connected with speech processor, and outfan is connected with transducer;
Described salinity test chart, for testing the brine strength placing implant;
Described transducer, for isolating the ground of saline and signal generator, input is connected with signal generator, exports the saline putting into implant place; Described implant is placed in a rectangular tank, and implant consideration container inner wall and put into bottom, the stimulating electrode of implant is put along chamber wall, and speech processor, at container outer wall, adsorbs through the thick dividing plate of 4-6mm and implant; The wire that the output signal anode of transducer connects is placed on the stimulating electrode upper 10-40mm of implant, fixes along container inner wall; The wire that the output signal negative terminal of transducer connects is placed on the receiving coil upper of implant, and the wire horizontal direction be connected with output signal anode is alignd, and fixes along container inner wall;
Described debugging box, instruction morphing for the acceptable signal of speech processor for what sent by computer, input is connected with computer, and output is connected with speech processor.
Alternatively, the input signal of described signal generator connects the exit trig interface at the back side; Output signal anode connects the 3rd foot input signal anode of transducer, and negative terminal connects the 1st foot input signal negative terminal of transducer.
Alternatively, described saline is for convert into pure water with 0.9% normal saline.
Alternatively, the concentration of described saline is 1.5-1.6 ‰.
Alternatively, described transducer is 1:1 audio-frequency transformer.
Based on above-mentioned purpose, present invention also offers the method for a kind of artificial cochlea's analog neuron remote measurement, comprise the following steps:
Get long 80-100mm, wide 70-90mm, high 15-20mm, the rectangular tank of wall thickness 2-3mm, container inner wall is shown consideration in implantation and puts into bottom, the stimulating electrode of implant is put along chamber wall, and speech processor, at container outer wall, adsorbs through the thick dividing plate of 4-6mm and implant;
The wire that the output signal anode of transducer connects is placed on the stimulating electrode upper 10-40mm of implant, fixes along container inner wall; The wire that the output signal negative terminal of transducer connects is placed on the receiving coil upper of implant, and the wire horizontal direction be connected with output signal anode is alignd, and fixes along container inner wall;
In container, convert into the saline of salinity 1.5 ‰ ~ 1.6 ‰ with 0.9% normal saline and pure water, salt water depth is minimum floods implant completely;
Speech processor is connected with computer through debugging box, speech processor exports and is connected with the exit trig interface at the signal generator back side, the output signal anode of signal generator connects the 3rd foot input signal anode of transducer, and negative terminal connects the 1st foot input signal negative terminal of transducer;
Carry out impedance measurement to each stimulating electrode of implant, confirm without short circuit, open circuit stimulating electrode, the minimum electrode of selection resistance value and the maximum electrode of resistance value are as measurement electrode;
Arrange neural telemetry parameter, the interval of masking signal and stimulus signal is 480 or 510 μ s; Shelter electrode and stimulating electrode selects same electrode or adjacent electrode or an electrode of being separated by; Recording electrode and stimulating electrode select same electrode or adjacent electrode or an electrode of being separated by; The amplitude of stimulus signal is 100-120CL, at least large than the amplitude of the stimulus signal 10CL of amplitude of masking signal; Gather a point every 8 or 16 or 32 μ s during recording electrode record, gather 100 points altogether, amplification is 40 or 160 times;
During without any signal, the waveform of surveying record electrode, obtains baseline noise;
Open speech processor, send synchronizing signal to signal generator, export the sine wave at least three cycles after the exit trig interface to synchronizing signal of signal generator, output to after transducer in saline; Speech processor only has a stimulus signal during there is no masking signal, send synchronizing signal, thus the nerve signal distribution process of Reality simulation human body.
Postpone the waveform that 60-100 μ s starts surveying record electrode, whether to obtain exporting with signal generator cycle identical sinusoidal wave, judge whether stimulation is normal.
Alternatively, masking signal and stimulus signal are first minus phase pulse, rear positive phase pulse, and have interval between negative positive pulse, pulse width is 25 ~ 50 μ s.
Alternatively, described baseline noise is not more than 100 μ V.
Alternatively, described sine wave freuqency is 10kHz, and amplitude is 5mV, and when when recording electrode record, amplification is 160 times, the waveform peak-to-peak value measured is not less than 200 μ V.
Alternatively, after the waveform of surveying record electrode, the output of shutdown signal generator, the waveform of surveying record electrode, as background record, for making negative control.
As can be seen from above, artificial cochlea's analog neuron telemetry system provided by the invention and method, by adopting the cooperation of signal generator and transducer in saline, analog neuron signal, thus the nerve stimulation performance of artificial cochlea is detected, avoid the impact operation that to go wrong when testing in implantation, it also avoid artificial cochlear stimulation acoustic nerve after implanting and lost efficacy, stimulate the problems such as excessive or too small, while improve security reliability, also reduce cost.
Accompanying drawing explanation
Fig. 1 is the system block diagram of embodiment of the present invention artificial cochlea analog neuron telemetry system;
Fig. 2 is the structural representation of embodiment of the present invention artificial cochlea analog neuron telemetry system;
Fig. 3 is the schematic flow sheet of the embodiment of the present invention artificial cochlea analog neuron method of telemetering.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
Consult shown in Fig. 1,2, for system block diagram and the structural representation of embodiment of the present invention artificial cochlea analog neuron telemetry system, comprise signal generator 105, salinity test chart 107, transducer 106, debugging box 102, speech processor 103, implant 104, wherein
Described signal generator 105, for receiving synchronizing signal, sine wave output analog neuron signal, input is connected with speech processor 103, and outfan is connected with transducer 106;
Described salinity test chart 107, for testing saline 117 concentration of placing implant 104;
Described transducer 106, for isolating saline 117 and the ground of signal generator 105, inputting and being connected with signal generator 105, exporting the saline 117 putting into implant 104 place; Described implant 104 is placed in a rectangular tank, and implant 104 pastes container inner wall and puts into bottom, and the stimulating electrode 114 of implant 104 is put along chamber wall, and speech processor 103, at container outer wall, adsorbs with implant 104 through the thick dividing plate 108 of 4-6mm; The wire 116 that the output signal anode of transducer 106 connects is placed on the stimulating electrode 114 upper 10-40mm of implant 104, fixes along container inner wall; The wire 126 that the output signal negative terminal of transducer 106 connects is placed on receiving coil 124 upper of implant, and wire 116 horizontal direction be connected with output signal anode is alignd, and fixes along container inner wall;
Described debugging box 102, instruction morphing for the acceptable signal of speech processor 103 for what sent by computer 101, input is connected with computer 101, and output is connected with speech processor 103.
Further, the input signal of described signal generator 105 connects the exit trig interface at the back side; Output signal anode connects the 3rd foot input signal anode of transducer 106, and negative terminal connects the 1st foot input signal negative terminal of transducer 106.
Further, described saline 117 is for convert into pure water with 0.9% normal saline.
Further, the concentration of described saline 117 is 1.5-1.6 ‰.
Further, described transducer 106 is 1:1 audio-frequency transformer.
Fig. 3 is the schematic flow sheet of the embodiment of the present invention artificial cochlea analog neuron method of telemetering, comprising:
S101, gets long 80-100mm, wide 70-90mm, high 15-20mm, the rectangular tank of wall thickness 2-3mm, shows consideration for container inner wall by implantation and puts into bottom, the stimulating electrode of implant is put along chamber wall, and speech processor, at container outer wall, adsorbs through the thick dividing plate of 4-6mm and implant;
S102, is placed on the stimulating electrode upper 10-40mm of implant, fixes along container inner wall by the wire that the output signal anode of transducer connects; The wire that the output signal negative terminal of transducer connects is placed on the receiving coil upper of implant, and the wire horizontal direction be connected with output signal anode is alignd, and fixes along container inner wall;
S103, converts into the saline of salinity 1.5 ‰ ~ 1.6 ‰ in container with 0.9% normal saline and pure water, salt water depth is minimum floods implant completely;
S104, speech processor is connected with computer through debugging box, speech processor exports and is connected with the exit trig interface at the signal generator back side, and the output signal anode of signal generator connects the 3rd foot input signal anode of transducer, and negative terminal connects the 1st foot input signal negative terminal of transducer;
S105, carries out impedance measurement to each stimulating electrode of implant, confirms without short circuit, open circuit stimulating electrode, and the minimum electrode of selection resistance value and the maximum electrode of resistance value are as measurement electrode;
S106, arranges neural telemetry parameter, and the interval of masking signal and stimulus signal is 480 or 510 μ s; Shelter electrode and stimulating electrode selects same electrode or adjacent electrode or an electrode of being separated by; Recording electrode and stimulating electrode select same electrode or adjacent electrode or an electrode of being separated by; The amplitude of stimulus signal is 100-120CL, at least large than the amplitude of the stimulus signal 10CL of amplitude of masking signal;
S107, during without any signal, the waveform of surveying record electrode, obtains baseline noise;
S108, opens speech processor, sends synchronizing signal to signal generator, exports the sinusoidal wave array at least three cycles, output in saline after transducer after the exit trig interface to synchronizing signal of signal generator;
S109, postpones the waveform that 60-100 μ s starts surveying record electrode.
Further, masking signal and stimulus signal are first minus phase pulse, rear positive phase pulse, have interval between negative positive pulse.
Further, described baseline noise is not more than 100 μ V.
Further, described sine wave freuqency is 10kHz.
Further, after the waveform of step S109 surveying record electrode, the output of shutdown signal generator, the waveform of surveying record electrode, as background record, for making negative control.
Those of ordinary skill in the field are to be understood that: the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. artificial cochlea's analog neuron telemetry system, is characterized in that, comprises signal generator, salinity test chart, transducer, debugging box, speech processor, implant, wherein,
Described signal generator, for receiving synchronizing signal, sine wave output analog neuron signal, input is connected with speech processor, and outfan is connected with transducer;
Described salinity test chart, for testing the brine strength placing implant;
Described transducer, for isolating the ground of saline and signal generator, input is connected with signal generator, exports the saline putting into implant place;
Described debugging box, instruction morphing for the acceptable signal of speech processor for what sent by computer, input is connected with computer, and output is connected with speech processor.
2. artificial cochlea's analog neuron telemetry system according to claim 1, is characterized in that, the input signal of described signal generator connects the exit trig interface at the back side; Output signal anode connects the 3rd foot input signal anode of transducer, and negative terminal connects the 1st foot input signal negative terminal of transducer.
3. artificial cochlea's analog neuron telemetry system according to claim 1, it is characterized in that, described saline is for convert into pure water with 0.9% normal saline.
4. artificial cochlea's analog neuron telemetry system according to claim 3, is characterized in that, the concentration of described saline is 1.5-1.6 ‰.
5. the artificial cochlea's analog neuron telemetry system according to Claims 1-4 any one, is characterized in that, described transducer is 1:1 audio-frequency transformer.
6. a method for artificial cochlea's analog neuron remote measurement, is characterized in that, comprises the following steps:
Get long 80-100mm, wide 70-90mm, high 15-20mm, the rectangular tank of wall thickness 2-3mm, container inner wall is shown consideration in implantation and puts into bottom, the stimulating electrode of implant is put along chamber wall, and speech processor, at container outer wall, adsorbs through the thick dividing plate of 4-6mm and implant;
The wire that the output signal anode of transducer connects is placed on the stimulating electrode upper 10-40mm of implant, fixes along container inner wall; The wire that the output signal negative terminal of transducer connects is placed on the receiving coil upper of implant, and the wire horizontal direction be connected with output signal anode is alignd, and fixes along container inner wall;
In container, convert into the saline of salinity 1.5 ‰ ~ 1.6 ‰ with 0.9% normal saline and pure water, salt water depth is minimum floods implant completely;
Speech processor is connected with computer through debugging box, speech processor exports and is connected with the exit trig interface at the signal generator back side, the output signal anode of signal generator connects the 3rd foot input signal anode of transducer, and negative terminal connects the 1st foot input signal negative terminal of transducer;
Carry out impedance measurement to each stimulating electrode of implant, confirm without short circuit, open circuit stimulating electrode, the minimum electrode of selection resistance value and the maximum electrode of resistance value are as measurement electrode;
Arrange neural telemetry parameter, the interval of masking signal and stimulus signal is 480 or 510 μ s; Shelter electrode and stimulating electrode selects same electrode or adjacent electrode or an electrode of being separated by; Recording electrode and stimulating electrode select same electrode or adjacent electrode or an electrode of being separated by; The amplitude of stimulus signal is 100-120CL, at least large than the amplitude of the stimulus signal 10CL of amplitude of masking signal;
During without any signal, the waveform of surveying record electrode, obtains baseline noise;
Open speech processor, send synchronizing signal to signal generator, export the sine wave at least three cycles after the exit trig interface to synchronizing signal of signal generator, output to after transducer in saline;
Postpone the waveform that 60-100 μ s starts surveying record electrode.
7. the method for artificial cochlea's analog neuron according to claim 6 remote measurement, is characterized in that, masking signal and stimulus signal are first minus phase pulse, rear positive phase pulse, has interval between negative positive pulse.
8. the method for artificial cochlea's analog neuron according to claim 6 remote measurement, is characterized in that, described baseline noise is not more than 100 μ V.
9. the method for artificial cochlea's analog neuron according to claim 8 remote measurement, is characterized in that, described sine wave freuqency is 10kHz.
10. the method for the artificial cochlea's analog neuron remote measurement according to claim 6 to 9 any one, is characterized in that, after the waveform of surveying record electrode, the output of shutdown signal generator, the waveform of surveying record electrode, as background record, for making negative control.
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