CN104870061A - Pulmonary system resistance training apparatus and methods - Google Patents
Pulmonary system resistance training apparatus and methods Download PDFInfo
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- CN104870061A CN104870061A CN201380053040.6A CN201380053040A CN104870061A CN 104870061 A CN104870061 A CN 104870061A CN 201380053040 A CN201380053040 A CN 201380053040A CN 104870061 A CN104870061 A CN 104870061A
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- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B23/00—Exercising apparatus specially adapted for particular parts of the body
- A63B23/18—Exercising apparatus specially adapted for particular parts of the body for improving respiratory function
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- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B21/00—Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices
- A63B21/008—Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices using hydraulic or pneumatic force-resisters
- A63B21/0085—Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices using hydraulic or pneumatic force-resisters using pneumatic force-resisters
- A63B21/0088—Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices using hydraulic or pneumatic force-resisters using pneumatic force-resisters by moving the surrounding air
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0866—Passive resistors therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
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- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B21/00—Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices
- A63B21/00196—Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices using pulsed counterforce, e.g. vibrating resistance means
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- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B2213/00—Exercising combined with therapy
- A63B2213/005—Exercising combined with therapy with respiratory gas delivering means, e.g. O2
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Rehabilitation Tools (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a respiratory exerciser having a hollow body, wherein the hollow portion is in communication with a porous or non-porous material and with an opening that provides access for a user to breathe through the device.
Description
Background technology
Breathing exercising device is designed for following object substantially, comprises and assists due to chronic obstructive pulmonary disease (COPD) or postoperatively lose spontaneous deep breathing and have the patient of lung's problem.The type of device is different, and a type can provide inspiratory resistance, and Second Type can provide expiratory resistance.Apparatus design becomes so that resistance changeable adjusts intensity or the " weakness " of the change of user.
Other respiratory training devices comprise large and/or complicated multiple component assemblies in spring, valve, barrier film otch and/or aperture, e.g., and United States Patent(USP) Nos. 6,726,598,5,899,832 and 4,739, the device in 987, their content by reference and entirety is incorporated herein.
Other devices show the expiration via porous member, e.g., U.S. Patent No. 7,921,964 and WO 2009/106062 shown in, their full content is by reference and entirety is incorporated herein.But, in these other devices, attempt the strength and the minimum pressure that make expiration, and via the air-breathing of porous plastics because valve restriction is to avoid drowning but impossible.
Summary of the invention
A kind of lung exercising apparatus comprises rigid body, this rigid body can be formed by non-porous materials or at least in part by porous material (such as, porous plastics) formed, the interface (mouthpiece) that there is inner space and be communicated with this inner space.In certain embodiments, the surrounding air of rigid body outside can enter in inner space through porous material, and then during inspiratory event with orifice.In certain embodiments, this kind of suction gas be communicated with can when do not have following in one or both occur: (1) is by the connection of nonadjustable check valve, or (2) are by means of the external high pressure air pushed by air-flow in the lung of user or oxygen source.
In another embodiment, the method of lung's strength of a kind of user of increase comprises the following steps: obtain porous plastics lung exerciser, it is at least made up of following: (a) has the rigid body of internal path, b interface that () is communicated with internal path, and (c) at least one porous plastics part; With by interface air-breathing, make air-breathing that the part in air is forced through porous plastics part, thus increase air-breathing strength, wherein, surrounding air and interface are by porous plastics members.
In another embodiment, lung's exercising apparatus comprises: rigid body, and it is formed by porous plastics at least in part and has inner space; And the interface to be communicated with this inner space, wherein, the air sucked by user can be communicated with the surrounding air of rigid body outside during expiration event, and is not communicated with valve, wherein, user's experience under 1 liter of gettering rate per second is greater than the resistance of the water of 26 inches.
In one embodiment, the present invention includes device body, this device body is suitable for receiving removedly: (a) has the check valve of the opening pressure being less than 1 psi; (b) interface; (c) at least one other component that box, valve and dead space introduce parts are selected from.
A kind of lung exercising apparatus comprises: rigid body, it is formed by porous plastics at least in part, have the porous between 5 microns and 250 microns and the wall thickness between 0.05 inch and 0.5 inch, wherein, rigid mount body is suitable for receiving removedly: (a) interface; (b) at least one other component, it is selected from: (1) box, it has the porous between 5 microns and 250 microns and the wall thickness between 0.05 inch and 1 inch, wherein, the porous of box or wall thickness are different from porous or the wall thickness of device body, (2) valve, it has the opening pressure being less than 1 psi, and (3) dead space introduces parts.
Also disclose additional using method and other embodiments.
Accompanying drawing explanation
Hereafter by means of the example shown in accompanying drawing, other details are described, in the accompanying drawings:
Fig. 1 shows the various perspective views of embodiments of the invention;
Fig. 2 shows the view profile of the A-A line along Fig. 1 (c);
Fig. 3 shows the alternative of the datum line A-A using Fig. 1 (c);
Fig. 4 shows the view profile of embodiments of the invention;
Fig. 5 shows adjustable embodiment of the present invention; And
Fig. 6 shows ergonomics embodiment of the present invention.
Detailed description of the invention
The present invention relates to respiratory training device, and more specifically, relate to promote user suitably or the respiratory training device of stronger air-breathing and expiration.
As other resistance exercises, air-breathing and expiratory resistance training can improve athletic performance.In some cases, performance can improve between percent 1 and 10, and more generally between about percent 2 and about percent 7, wherein about percent 5 is not significantly improving of physiology/athletic performance.In certain embodiments, the present invention can be configured to provide flow resistance load, pressure threshold load or etc. one or more of in carbon dioxide hyperpnea (isocapnic hyperpnea).In certain embodiments, the present invention can be configured to provide flow resistance load, pressure threshold load or etc. the one in carbon dioxide hyperpnea, and additional operator scheme (such as, flow resistance and optional pressure threshold and/or etc. carbon dioxide hyperpnea) is provided alternatively.In one embodiment, the present invention can be configured to provide following two or more: flow resistance load, pressure threshold load or etc. carbon dioxide hyperpnea.
In certain embodiments, the present invention includes device body.Device body can be non-porous, or comprises the porous part of the part as a whole or as device body.In some other embodiment, the present invention comprise that optional box, optional valve and optional dead space introduce in parts alternatively one or more.
In certain embodiments, respiratory training device of the present invention comprises rigidity or semi-rigid body, wherein body limits inner space or hollow space, and with the interface that is communicated with of inner space gas ground, wherein the surrounding air of body exterior can enter in inner space through porous material, and then during inspiratory event with orifice.As alternative, the air of exhalation can enter inner space from user, and is then communicated with the surrounding air of outside of the present invention after passing porous material part.In certain embodiments, during inspiratory event, some or a part in surrounding air can with orifice, and can not first to open or through check valve.In other embodiments, some or a part in the air of exhalation can be communicated with surrounding air, and can not first open or through check valve.
As used herein, common term " device of the present invention " or " the present invention " are interpreted as individually or comprise each in device body, box, valve or dead space introducing parts with any combination, and this is pointed out by context and description.
In another embodiment, the present invention includes lung's exercising apparatus, it comprises the device body being shaped as and limiting inner space, interface boss, cooperate with rigid body and be communicated with inner space, thus allow the check valve that the direction along the surrounding air outside from inner space to rigid body is communicated with, the air that freely allows be communicated with inner space to flow into inner space from surrounding air and also flows to the aperture of surrounding air from inner space, be suitable for the selector in closed at least arbitrary check valve or aperture, cooperate with rigid body and allow the porous plastics parts be communicated with between inner space with surrounding air, be connected to interface boss and the interface be communicated with described inner space, wherein, surrounding air is not communicated with by valve by porous plastics members with interface.
In certain embodiments, the present invention includes device body linear substantially, or in certain embodiments, comprise be connected with interface W shape, U-shaped, T-shaped or L shape body.Whole device body is not, all or part of can be made up of porous material, such as, and porous ceramics, porous metals or porous plastic materials.In certain embodiments, weight of the present invention is enough low, to allow user of the present invention the present invention to be held individually in the mouth of user by using interface.In this kind of embodiment, when user to sting downwards on interface and uses of the present invention, weight of the present invention can make lower jaw minimum fatigue, and also allows to use without hand, such as, in running, by bike, stair climbing or relate to other exercise periods that are cardiovascular or muscular training.
Porous part of the present invention (such as, device body and/or box, and/or valve and/or dead space introduce all or part of of parts) comprises the chamber of pore or interconnection, thus allows to be communicated with throughout the gas of solid porous part or fluid.And therefore these pores allow surrounding air to be communicated with inner space of the present invention, and, surrounding air is with orifice and be communicated with the lung of user by means of interface.Be different from aperture, porous part produces and is used for many (such as, thousands of) indirect path that air travels across material.By controlling porous and the wall thickness of part of the present invention, can produce less, gentlier, the respiratory resistance device that more more simplifies of easy cleaning, ergonomic shape and entirety is for use.
If device body is non-porous, or has a part of porous material, then in this kind of embodiment, one or more additional porous box can be connected to device body, produces the additional porous barrier between surrounding air and user.If the whole or major part of device body is porous, then box also still can use and be connected to device body.
Referring to porous part, porous and wall thickness affect the resistance experienced by user.Describe hereinafter separately.
Porous
As described herein, part of the present invention (such as, device body or box) can have different porous.As limited in standard multi-well measurement examination, the porous of part of the present invention can be between 5 and 200 mum.In certain embodiments, porous can between 5 and 100 microns.In certain embodiments, porous can between 5 and 80 microns.In certain embodiments, porous can between 5 and 50 microns.In certain embodiments, porous can between 5 and 25 microns.In certain embodiments, porous can between 10 and 50 microns.In certain embodiments, porous can between 25 and 100 microns.In certain embodiments, porous can between 25 and 200 microns.In certain embodiments, porous can between 50 to 150 microns.In certain embodiments, porous can between 25 and 250 microns.
In certain embodiments, device body or box or valve are (such as, pressure threshold parts) or the dead space porous of porous part (if there is) of introducing parts be selected from following: about 5 microns, about 10 microns, about 20 microns, about 30 microns, about 40 microns, about 50 microns, about 60 microns, about 70 microns, about 80 microns, about 90 microns, about 100 microns, about 110 microns, about 120 microns, about 130 microns, about 140 microns, about 150 microns, about 160 microns, about 170 microns, about 180 microns, about 190 microns, about 200 microns, about 210 microns, about 220 microns, about 230 microns, about 240 microns, about 250 microns, about 260 microns, about 270 microns, about 280 microns, about 290 microns, about 300 microns.
In certain embodiments, porous is less than 300 microns.
In certain embodiments, porous is less than 200 microns.
In certain embodiments, porous is less than 100 microns.
In certain embodiments, porous is less than 75 microns.
In certain embodiments, porous is between 5 microns and 25 microns.
In certain embodiments, porous is between 5 microns and 250 microns.
Material thickness
In certain embodiments, the thickness of the material of a part (such as, device body or box) for device for limiting can between about 0.1 inch and about 2.0 inches.In porous embodiment, the thickness of porous material is between about 0.1 inch and about 1.0 inches.In certain embodiments, wall thickness is between about 0.05 and about 0.15 inch.In certain embodiments, the thickness of porous material is about 0.1 inch.In certain embodiments, the thickness of porous material is about 0.2 inch.In certain embodiments, the thickness of porous material is about 0.3 inch.In certain embodiments, the thickness of porous material is about 0.4 inch.In certain embodiments, the thickness of porous material is about 0.5 inch.In certain embodiments, the thickness of porous material is about 0.6 inch.In certain embodiments, thickness is between 0.1 and 0.6 inch.In certain embodiments, thickness is between about 0.1 and about 0.15 inch.In certain embodiments, thickness is between about 0.05 and 0.2 inch.In certain embodiments, thickness is between about 0.05 and 0.5 inch.In certain embodiments, thickness is between about 0.05 and 1 inch.
The porous material restriction air stream used in the present invention to provide inspiratory resistance, expiratory resistance or both.
In the embodiment of some light weight and/or easy cleaning, of the present inventionly all or part ofly can be made up of porous plastics.In certain embodiments, polyethylene (PE), ultra-high molecular weight polyethylene (UHMWPE), high density polyethylene (HDPE) (HDPE), polypropylene (PP), polytetrafluoroethylene (PTFE) (PTFE) and polyvinylidene fluoride (PVDF) are applicable.Ethylene vinyl acetate (EVA), polyether sulfone (PES), polyurethanes (PU) and PE/PP copolymer are also applicable.Material or its part can be hydrophobic or hydrophilic.Porous plastic materials can easily from Genpore, and 136 Morgantown Rd., Reading, PA 19607 obtains.
Air-breathing and expiration strength
In certain embodiments, porous of the present invention and variable wall thickness, with the following load providing air-breathing, expiration or experienced by user during both.Air-breathing strength, expiration strength or both be suitable for being used alone device body, and use the device body combined with one or more box and/or pressure threshold parts (such as, fix or adjustable check valve).
Breathe load can be classified into gently, neutralize heavy resistance, and be applied to flow resistance load and pressure threshold load.Until there is overlapping degree in scope, this overlap in feature can relate to the perception of individual user.
In certain embodiments, resistance is the water under 1 liter of speed (air-breathing or expiration) per second between 26 and 300cm.In certain embodiments, resistance be 1 liter per second under be more than or equal to the water of 26cm.But in certain embodiments, inspiratory resistance can be less, and in certain embodiments, air-breathing or expiratory resistance are 1 liter of lower water of 10 to 25cm per second.
Light resistance can be 1 liter per second lower between 26 and the water of 110cm.In certain embodiments, resistance is the water of 1 liter of lower about 35cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 45cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 56cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 65cm per second.In certain embodiments, resistance be 1 liter per second under the water of about 75cm.In certain embodiments, resistance be 1 liter per second under the water of about 90cm.
Medium resistance can be 1 liter of lower water between 26 and 190cm per second.In certain embodiments, resistance can be 1 liter of lower resistance between 56 and 180cm per second.In certain embodiments, resistance can be 1 liter per second under be more than or equal to the water of about 56cm.In certain embodiments, resistance is the water of 1 liter of lower about 70cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 100cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 140cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 160cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 170cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 180cm per second.
Heavy resistance can be 1 liter of lower water between 30 and 300cm per second.In certain embodiments, heavy resistance can be 1 liter of lower water between 150 and 270cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 150cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 200cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 230cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 250cm per second.In certain embodiments, resistance is the water of 1 liter of lower about 270cm per second.
In certain embodiments, resistance be 1 liter per second under be greater than the water of 56cm.In certain embodiments, resistance is between the water of 1 liter of lower 56cm per second and the water of 300cm.
In certain embodiments, in device body, box or valve one or more can by vibration or oscillation action give air-breathing, expiration or both.In certain embodiments, vibrate between 6 to 12Hz.In certain embodiments, vibrate between 20 and 40Hz.In other embodiments, vibration is greater than 20Hz.In certain embodiments, vibrate for about 5,6,7,9,10,12,13,14,15,16,17,18,19,20,22,24,25,30,35Hz.
After this description introduces each in parts for hyperpneic device body such as carbon dioxide such as grade, box, valve and dead space.
Device body
The device body of whole device of the present invention generally defines inside (such as, hollow) space, and through this space, usually through interface, exhalation and the air sucked can advance to user from ambient air outside.
In certain embodiments, the device body limiting inner space can by any material as plastics or metal be made.In certain embodiments, whole body can be solid non-porous materials (such as, plastics).
But, in other embodiments, device body at least partially by porous material as pottery or porous plastics make.In some porous embodiment, the present invention does not require inner space to work.In some porous embodiment, the porous material that can be the inner hollow space clearly do not limited of whole device body.
In certain embodiments, porous material is derived from least 10% (not comprising any valve, interface, interface boss, accessory, plug or box) of the gross weight of device body.In other embodiments, the weight of at least 20% is porous material.In other embodiments, the weight of at least 30% is porous material.In other embodiments, the weight of at least 40% is porous material.In other embodiments, the weight of at least 50% is porous material.In other embodiments, the weight of at least 60% is porous material.In other embodiments, the weight of at least 70% is porous material.In other embodiments, the weight of at least 80% is porous material.In other embodiments, the weight of at least 90% is porous material.In other embodiments, the weight of at least 95% is porous material.In other embodiments, device body is entirely porous.
In certain embodiments, device body (such as, introducing parts, interface etc. without any box, dead space) is light weight, and weight is less than 5 ounces.In certain embodiments, device body weight is less than 4.5 ounces.In certain embodiments, device body weight is less than 4.0 ounces.In certain embodiments, device body weight is less than 3.5 ounces.In certain embodiments, device body weight is less than 3.0 ounces.In certain embodiments, device body weight is between 1.0 and 4.0 ounces.In certain embodiments, device body weight is between 1.0 and 3.0 ounces.
In certain embodiments, time in use, the center of gravity of device (as determined without any when box or other components at device body, or determining during one or more comprising valve, during box, interface, dead space introduce parts etc.) is positioned at the lip nearside of user.In certain embodiments, center of gravity is less than 1cm from user's lip outer surface.In certain embodiments, center of gravity is less than 1.5cm from user's lip.In certain embodiments, center of gravity is less than 2cm from user's lip.In certain embodiments, center of gravity is less than 3cm from user's lip.In some configurations, center of gravity is positioned at user's lip front.It is conceivable that in some configurations, the center of gravity of device of the present invention can be located so that it is inside the mouth of user, in tooth nearside (such as, in oral cavity).In certain embodiments, the center of gravity conceiving device of the present invention user's lip or mouth nearside or contact corresponding thereto.
In certain embodiments, the present invention can be modular.In certain embodiments, the present invention includes device body, it is suitable for receiving removedly breathes relevant component, and such as, box, valve (nonadjustable or adjustable) or dead space introduce parts.In certain embodiments, the present invention includes device body, it is suitable for receiving removedly and is selected from least two following breathing components: box, valve (nonadjustable or adjustable) or dead space introduce parts.Breathing component at two or more is used in some embodiment of the present invention, breathes component and can be identical type (such as, two boxes) or dissimilar (such as, valve and box).
Box
In certain embodiments, when using device of the present invention, box can change, increases or reduce air-breathing or the expiration strength of device user of the present invention.
In certain embodiments, have any rule or erose one, two or three or more box can use together with device body.In certain embodiments, box can be conical or tubulose substantially.In certain embodiments, box also can limit inside (such as, hollow) space, and the inner space of box is directly communicated with the inner space of device body.
Box (or for other components of the present invention) by removable or permanent means as thread connection, be clasped, adhesive, heat apply etc. be placed in the inner space fluid of device body (in the case, fluid is interpreted as and contains gas or liquid) be communicated with.This kind of attachment method can be and the entirety of material or one piece construction, or by using adhesive or ultra-sonic welded etc. to be bonded to material.
As described above, the porous identical or different with device body, wall thickness or material composition can be had for box of the present invention.Difference in these factors between device body and box allows customization air-breathing and expiration strength, to be applicable to the needs of specific user, and does not need spring, barrier film or valve.
Comprise in some embodiments of porous part at device body, the porous of box, the wall thickness of box or both can be different from device body.In certain embodiments, air stream is through the resistance relatively high compared with the resistance of box (such as, the water or larger of about 270cm) of device body.In this kind of embodiment, box is used to reduce the overall resistance to air-breathing or expiratory air stream by providing having of being communicated with surrounding air with interface compared with the path of slight drag.Therefore, the air-breathing strength of device of the present invention and/or expiration strength adjust by the porous and/or wall thickness changing the box being communicated with device body and/or being communicated with the inner space of device body.
Any resistance mentioned above is all applicable to box.In addition, comprise in some embodiment of porous part at device body, less than device body by 5% when device body is suitably used alone to the resistance of the air stream in box.In other embodiments, resistance ratios device body is little by about 10%.In other embodiments, resistance ratios device body is little by about 20%.In other embodiments, resistance ratios device body is little by about 30%.In other embodiments, resistance ratios device body is little by 40%.In other embodiments, resistance ratios device body is little by about 50%.In other embodiments, resistance ratios device body is little by 60%.In other embodiments, resistance ratios device body is little by about 70%.In other embodiments, resistance ratios device body resistance is little by about 80%.
In other embodiments, the resistance ratios device body little 5% to 30% of box.In other embodiments, resistance ratios device body little 5% to 80%.In other embodiments, resistance ratios device body little 10% to 50%.
In certain embodiments, box of the present invention can comprise check valve (such as, adjustable check valve, as described herein), and does not have alternatively or substantially do not have porous material.
In certain embodiments, box can be used for generation module gasifying device.In some this type of embodiment, one or more box can be stacking, be linked together or connect (such as, arrange linearly), or device body some design (such as, T-shaped designs) in, one or more box can alternatively be arranged with parallel way relative to device body.In other embodiments, one or more box can simultaneously in series and be also arranged in parallel.
Relative to user, in intake period, the first porous box can with have identical or different inspiratory resistance the second porous cassette in series (such as, in upstream) locate.Alternatively, unidirectional valve cap (such as, adjustable check valve) can be placed in upstream or downstream (such as, nearside or distally) relative to another box of any type.
In certain embodiments, for the box in the present invention, there is the weight between 0.1 and 1 ounce.In certain embodiments, box weight is less than 0.9 ounce.In certain embodiments, box weight is less than 0.8 ounce.In certain embodiments, box weight is less than 0.7 ounce.In certain embodiments, box weight is less than 0.6 ounce.In certain embodiments, box weight is less than 0.5 ounce.In certain embodiments, box weight is less than 0.4 ounce.In certain embodiments, box weight is less than 0.3 ounce.In certain embodiments, box weight is less than 0.2 ounce.
In certain embodiments of the present invention, box can have the opening on far-end, and they can alternatively by user's closure or openness.Opening can be suitable for storage to be treated and cassette in series (opening such as, relying on screw thread maybe can not clog) the ground additional member (such as, check valve) of placing.
The resistance of exhaling also is increased by changing the exposure, porous, wall thickness etc. of whole pore to surrounding air or reduced.In certain embodiments, adjustable lid or other coverings can be used for the amount reducing or increase the porous material exposed.
Alternatively, in certain embodiments, device of the present invention can comprise one or more aperture in the device body or box that can cover or expose to increase respectively or reduce resistance.
Valve
In certain embodiments, one, two or three or more check valve can be used for by change, promote or alleviate air-breathing strength, expiration strength or both affect the functional of device of the present invention.In another embodiment, can comprise valve as check valve (such as, the check valve of adjustable or nonadjustable reed or flaps type), hole or aperture, to affect the functional of device, user can be closed effectively or reduce (at least 50% or 100%) significantly or substantially eliminate the air-breathing or expiratory resistance that are caused by device.Check valve can with device body entirety combine, maybe can use those skilled in the art reading present disclosure after clearly connection type connect (such as, threaded engagement, bayonet fittings or bonding cooperation).In one embodiment, check valve (such as, adjustable check valve) can be connected to device body removedly, and/or substitutes porous material box of the present invention, or series connection with it or use in parallel.
Check valve can be used for depending on the orientation of valve relative to the fluid stream (such as, air) through valve, and whether air-breathing or the expiration of choice for use person experience any appreciable resistance.When being oriented in primary importance, valve allows air-breathing, but prevents or substantially stop the expiratory flow by valve.In the opposite location of primary importance, when being oriented in the second place, valve allows to exhale, but prevents or substantially stop the inspiratory flow by valve.Check valve also can be used for giving threshold resistor load, because must be over threshold load before valve is by unlatching, and threshold value must maintain so that valve is held open.Check valve can be used alone or combinationally uses with porous material.
Such as, check valve (adjustable or nonadjustable) can be used for and be oriented allowing the air of breathing out from user by the valve device body and to the quick release in surrounding air.But when air-breathing, check valve closes, thus air-breathing strength is forced to increase when the air sucked travels across other components of box, porous part or device.In certain embodiments, the opening pressure of valve (comprising nonadjustable valve) can be less than: 1.0 psi, 0.3 psi, 0.2 psi, 0.15 psi or 0.09 psi.In certain embodiments, opening pressure is less than 0.17 psi.In certain embodiments, opening pressure can be the initial opening pressure needed for adjustable check valve.
In other embodiments, check valve adjustable, so that outside the porous part (such as, device body or box) of device, valve self provides the change of resistance by Compress Spring, diaphragm etc.This kind of embodiment provides resistance (that is, breathing load), and all can use together with valve of the present invention about any resistance described in device body above.In certain embodiments, device body has the large flow resistance of the resistance of the flowing of comparison valve.
The example of check valve, adjustable check valve or diaphragm and layout thereof can in U.S. Patent No. 6, and 726,598 and U.S. Patent No. 4,739, find in No. 987, its full content is incorporated to by reference at this.
In certain embodiments, unidirectional valve housing can be made up of porous material as described herein.
In certain embodiments, for the valve in the present invention, there is the weight between 0.1 and 1 ounce.In certain embodiments, valve weight is less than 0.9 ounce.In certain embodiments, valve weight is less than 0.8 ounce.In certain embodiments, valve weight is less than 0.7 ounce.In certain embodiments, valve weight is less than 0.6 ounce.In certain embodiments, valve weight is less than 0.5 ounce.In certain embodiments, valve weight is less than 0.4 ounce.In certain embodiments, valve weight is less than 0.3 ounce.In certain embodiments, valve weight is less than 0.2 ounce.
In certain embodiments, valve can have the opening on far-end, and it can alternatively by user's closure or openness (such as, by using thread plug etc.).Opening can be suitable for receiving the additional member (such as, box) of in series placing (such as, relying on the opening that screw thread maybe can not clog) with valve.
Parts are introduced for waiting hyperpneic dead space of carbon dioxide
Average total lung volume of adult human male is about 6 liters, and women is about 4.2 liters.Functional residual capacity stays the air capacity in lung after being normal exhalation.The male sex on average leaves about 2400ml, and women retains about 1800ml.Therefore, the male sex exhales 3.6 liters usually, and women exhales 2.4 liters usually.Residual capacity is the air stream stayed after forcing to exhale in lung.The average residual capacity of the male sex is 1200ml, and women is 1100ml.Lung capacity is the maximum air capacity can breathed out after maximum inhale, and wherein the male sex tends to be average 4800ml, and women is 3100ml.
In certain embodiments, device body of the present invention individually or combine with one or more in box or adjustable or nonadjustable valve member and provide or be enough to provide dead space volume.In certain embodiments, when do not have dead space introduce parts, the volume of device, individually or with in box or valve member one or more in combination, be not enough to larger reservation/accumulation that carbon dioxide is provided.
In some other embodiment, when do not have dead space introduce parts, the volume of device, individually or with in box or valve member one or more in combination, be enough to larger reservation/accumulation that carbon dioxide is provided.Therefore, in this kind of embodiment, device body and/or box and/or adjustable or nonadjustable valve member act as dead space forming member.
In other embodiments, the present invention includes the parts introducing dead space volume, wherein dead space is introduced parts and can be connected to device body removedly (such as in certain embodiments, it is modularizing member) on, or parts permanently can be attached to device body and/or as arranged in parallel or in series with one or more in box or valve publicly herein.Dead space introduces parts and can be any rule or irregular shape, and in certain embodiments, it can be tubulose.In certain embodiments, dead space reserved unit can be expansible or elastomer bag.
Dead space is introduced parts and be can be any material (such as, porous or non-porous) with any parameter as disclosed herein.The object of dead space volume and/or dead space introducing parts is the breaths in order to retain certain percentage in the total internal volume of device, thus at each subsequent inspiration and/or the carbon dioxide level keeping rising in exhaling in the apparatus of the present.This kind of reservation of carbon dioxide can reduce the generation of hyperventilation.
In certain embodiments, introduce in the manufacture of parts if porous material is used in dead space, individually or with box or adjustable valve member or dead space introduce in parts one or more in combination, eliminating can be present in the expiratory air scale of construction in the porous wall of device, then overall dead space is that the typical case of user exhales about 2%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55% of volume.In another embodiment, dead space introduces parts is enough to separately to retain the typical case of user and exhales about 2%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55% (or increasing overall volume of overall apparatus) of volume.Therefore, in certain embodiments, dead space introduces parts volume is about 1.08 liters (that is, 3.6 liters × 30%).
The additional information measured about CO2 can in U.S. Patent No. 4,601,465 and WO2007/089465 in find, its content is by reference and entirety is incorporated herein.
The method using and treat
The present invention can be used for treating or assisting to suffer from the patient of disordered breathing, comprises the patient of suffering from copd, neuromuscular disease, quadriplegia, the postoperative complication causing changing PFT, expiratory dyspnea, chronic congestive heart failure and other correlation circumstances.
Under the present invention is also used in movement background, assisted respiration is trained, and improves strength and the efficiency of breathing.In certain embodiments, can be arranged so that user can use between embodiments of the invention 3 to 300 minutes every day to air-breathing, expiration or both resistances.In certain embodiments, user can use the present invention a whole day termly or continuously.In certain embodiments, user can use the present invention every day 10 to 20 minutes.In certain embodiments, user can use the present invention more than 5 minutes every day.In certain embodiments, user can use the present invention more than 20 minutes every day.
In certain embodiments, the present invention can use in the mode consistent with resistance exercise.In certain embodiments, this kind of resistance exercise comprises the time cycle of expiration and/or inspiratory resistance, or the breathing of predetermined number by device of the present invention, after connect rest period, wherein do not use device of the present invention.In certain embodiments, the time cycle of the resistant breathing of tool be selected from about 10 seconds, about 15 seconds, about 20 seconds, about 25 seconds, about 30 seconds, about 45 seconds, about 60 seconds, 90 seconds, 120 seconds, about 10 to 40 seconds, about 10 seconds to about 60 seconds, about 10 seconds to 90 seconds, about 10 seconds to 120 seconds.
In some other embodiment, the training group of the breathing of predetermined number comprises between at least 5 times, at least 10 times, at least 12 times, at least 15 times, at least 20 times, at least 25 times, at least 30 times, at least 40 times, 5 and 15 times, between 10 and 20 breathings, between breathing for 20 and 40 times.
In other embodiments, rest period is selected from about 10 seconds, about 15 seconds, about 20 seconds, about 25 seconds, about 30 seconds, about 45 seconds, about 60 seconds, 90 seconds, 120 seconds, about 10 seconds to 40 seconds, about 10 seconds to about 60 seconds, about 10 seconds to 90 seconds, about 10 seconds to 120 seconds, about 6 hours, about 8 hours, about 12, and between 8 and 12 hours.When using in the mode consistent with resistance exercise, user be not usually physical activity (such as, do not run, by bike, carry out moving or other training, or in an alternative embodiment, user sits down, drive, or usually during operative installations, do not carry out cardiovascular or muscular training), and user mainly concentrates on lung's exercise.User can complete 1,2,3,4,5,6,7,8,9 or 10 group, has rest period between each group.In certain embodiments, user can complete 3 groups or more groups, has rest period between each group.
In certain embodiments, and as mentioned below, be formed as to ergonomics of the present invention enough little and/or enough light, make it can be used for endurance training or use during endurance training, take exercise simultaneously, such as, running, stair climbing, by bike, weight lifting, carry out aerobic exercise, walk, climb rocks or utilize kickboard to swim or other are movable time.
As alternative, device of the present invention can be used for the cycle more grown, and such as, gives or provide to climb the mountain or training at high altitude intensity for endurance training.In this kind of embodiment, device of the present invention can when the relative inertia of user (such as, the resistance exercise in long-term cycle) or resource-user cost method pass by/advance certain distance time use.
In one embodiment, user can use the present invention within the long-term time cycle in air-breathing, expiration or both processes.In one embodiment, device of the present invention can use about 3 minutes, about 4 minutes, about 5 minutes, about 10 minutes, about 15 minutes, about 20 minutes.In certain embodiments, the present invention can use between 10 minutes and 60 minutes.In other embodiments, user can use the present invention with the time cycle being greater than one hour.
In the embodiment that some endurance is relevant, user advances certain distance movably, simultaneously user also carries out cardiovascular exercise, and wherein distance is selected from: about 10 yards, about 100 yards, 1/4 mile, to not a half mile, at least one mile, at least 3.1 miles, at least 6.2 miles at least 10 miles, at least 13.1 miles, at least 20 miles, at least 26.2 miles, at least 30 miles, at least 50 miles, from 1 mile to 10 miles, from about 3.1 miles to 13.1 miles, about 1 mile to 20 miles.
In some other embodiments, user carries out height change movably with using this device constantly.In this embodiment, user can rise at least: about 10 feet, about 20 feet, about 30 feet, about 50 feet, about 100 feet, about 500 feet, about 1000 feet, or about 5000 feet.
In certain embodiments, device of the present invention can be constructed to air-breathing and expiration provides flow resistance load.In certain embodiments, device of the present invention can be configured to be only air-breathing and provide flow resistance load.In certain embodiments, device of the present invention can be configured to be only expiration and provide flow resistance load.In certain embodiments, device of the present invention can be constructed to air-breathing and expiration provides pressure threshold load.In certain embodiments, device of the present invention can be configured to be only air-breathing and provide pressure threshold load.In certain embodiments, device of the present invention can be configured to be only expiration and provide pressure threshold load.In certain embodiments, device of the present invention can be constructed to air-breathing and provide pressure threshold load, and provides flow resistance load for exhaling.In certain embodiments, device of the present invention can be constructed to air-breathing provides flow resistance load and provides pressure threshold resistance for exhaling.Can combinationally use with any one in previous constructions Deng carbon dioxide hyperventilation (such as, if device of the present invention does not provide enough dead spaces, then by using dead space to introduce parts).
Other components
In certain embodiments, the present invention can comprise nose clip and/or nose clip retainer with the nose of closed user, and thus force user to breathe by means of only the mouth of user, and therefore to breathe by means of only device of the present invention.Nose clip can be independent or combines with device entirety of the present invention.Alternatively, the present invention can use in combination with the nose inspiratory resistance training aids as shown in U.S. Publication No. 20130157810, and the content of this patent is incorporated herein by reference.
In other embodiments, the present invention includes two outstanding fritters, it act as the nose clogging user.Outstanding fritter can be solid plastic, soft material or porous plastics, or is applicable to any other material of the nose path stopping user at least in part.
Other embodiments also can comprise packaging and instruction for using device of the present invention, such as, comprise the external member of device.
Other embodiments also can comprise one, two or three or more folder part or eyelet, it allows necklace or line to be attached to a part for device of the present invention, to spue simply device of the present invention (or when device of the present invention drops out the mouth of user at exercise period) to allow user, the present invention can be hung around the neck of user, thus permission continue the generation without the operation of hand and the accident loss of minimizing device.Therefore, in one embodiment, the present invention includes the method still keeping holding this device while that user discharging device of the present invention (such as, from the mouth of user).In some other embodiment, necklace or line can comprise elastomeric material, so that be retained in the mouth of user by device of the present invention.Specifically, elastomeric material (such as, rubber or elasticity thing) provides the tension force around user's head to support.But, in certain embodiments, this type of supporting allow device of the present invention easily by spuing, with hand or the one or more of mouths from user of only having a loose tongue out in (such as, when losing consciousness) remove.
In some porous embodiment, porous character of the present invention also can allow annexing ingredient to be adhered to porous part.In this embodiment, disease (such as, hepatopathy, gastrointestinal disease, diabetes or cancer) detection come by utilizing applicable detection agent contact surface, make disease biomarkers in the air of saliva and exhalation (such as, nitrogen oxide, acetone, VOC) can be detected when disease biomarkers contacts with detection agent (such as, being changed by color).
In some other embodiment, the present invention includes porous member that is independent or that combine with flexible sheets (such as, neoprene), with thus resistance is provided.In this kind of embodiment, one or more in porous part as herein described can flexible sheets entirety combine therewith, make sheet form the face shield put on by user, what make face shield be formed on user face is at least partially sealed, thus causes user to be breathed by porous member.
In certain embodiments, the present invention is not provided for the sealing of nose, or does not have nasal seal (when needing this kind of sealing), and this kind of sealing can be provided by submember such as nose clip.
In certain embodiments, the component (such as, device body or box) of device of the present invention can be formed when not having adhesive.In certain embodiments, the part of whole device of the present invention can weld (such as, sound wave ground welding) together or frictional fit together.
Embodiment
Referring to Fig. 1 to 6, show various non-limiting example of the present invention.
The top perspective of the device body 100 of an embodiment of T-shaped of the present invention design is shown referring to Fig. 1, Fig. 1 (a).Fig. 1 (b) shows the front view of the device 100 with anterior 160.Anterior 160 can comprise selector 170 alternatively, select with artificially between only expiratory one-way valve 180, only breather cheek valve 200 and open aperture or valve 190.Selector 170 can be any design, and comprise and slide or rotate, this can be sealed again in rotational trajectory 210.
In addition, device 100 also can comprise Interface Matching boss 120 and optionally removable interface 110.As being described in further detail in Fig. 6, end 140 can be porous material, non-porous or end cap.Angle 150 can be from 0 degree to 90 degree, and wherein 15 to 25 or 30 to 55 degree are preferred.
Fig. 2 shows the view profile of the A-A line along Fig. 1 (c).Can be or also can not have wall thickness 133 (it can be the consistent of through-going device 100 or incomparable inconsistent thickness) for the device body 130 of porous, and which defines inside or hollow space 220.Plug 176 and 174 seal orifice of selector 170 or valve 200 and 190, thus allow only outlet valve check valve 180 to work.
Fig. 3 shows the alternative of the A-A line along Fig. 1 (c), and its medial end portions 140 is replaced with connection element 225.In one embodiment, screw thread 240 threadably engages connection element 225, so that porous box 230 is connected to device 100.In one embodiment, porous box 230 also comprises interior section 235.When box 230 is connected to device 100, the interior section 235 of box is communicated with the interior section 220 of device 100 body.
Fig. 4 shows the view profile of the Multiple-Aperture Device without any inner or hollow space.On the contrary, whole device 100 is made up of porous material completely.
Fig. 5 shows adjustable embodiment of the present invention.Lid 550 threadably engages box 500 via the bolt portion 555 in threaded portion 510 and perforate 560.As alternative, can there be screw thread the outside of box 500, is threaded onto box 500 to allow card 550.
Covered the distance X of box 500 by adjustment lid, can increase or reduce the amount of the surface area exposed, thus increase or reduce the resistance of air-breathing or the expiration felt by user.Such as, when the amount exposing area increases to Y, the expiration strength experienced by user reduces.Expiration strength relies on one-way exhaust valve 180 to remain minimum, and its rotary selector 610 is exposed to surrounding air, covers open aperture 190 simultaneously.
In addition, aperture 557 can be present in a part for device body 130 or box 500 or 210.Aperture 210 can be covered by user or expose, to change the strength of the breathing experienced by user further.
Fig. 6 shows alternative, wherein replaces end 140 with connection element 605.Device 100 also has angled end 120.In one embodiment, screw thread 240 threadably engages connection element 225, so that porous box 230 is connected to device 100.In one embodiment, other ends 605 are connected to the plug 620 with screw thread 625, the screw thread 240 of screw thread 625 roughly matching box 230.Plug 620 tightens by any means or unclamps, but as shown in Figure 6, lug 622 can be used for rotating piston clockwise or counterclockwise, thus unclamps or tighten plug 620.
Term as used herein " approximately " be meant to reference value+or-10%, comprise reference value.Therefore, " about 10 " are interpreted as both the scopes supporting " 10 " and " 9 to 11 " completely, and whether term " approximately " is interpreted as and is applicable to each value in this paper alternatively, no matter and explicitly point out in the disclosure.Therefore, such as, the value of " 10% " in this paper is interpreted as the claim restriction of support " 10% " and the claim restriction of " about 10% ".
It will also be appreciated that the independent values of a part for the inventory being provided as value can be selected independently.Such as, " 2%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55% " is interpreted as that being meant to any particular value can be selected from this inventory, and is used alone or advocates right, such as, and 2% to 30%, 55% or about 55%).
In this disclosure, various embodiment of the present invention is illustrate and described.But as mentioned above, the present invention can use in other combinations various and environment, and can change or change in the scope of the invention conception such as represented herein.Various embodiment can change or combine with other embodiments, and does not change or change the scope of the present disclosure.
Each and each reference of setting forth in the disclosure as in this article completely explaination at this by reference and entirety is incorporated to.
Claims (20)
1. lung's exercising apparatus, it comprises:
Rigid body, it is formed by porous material at least in part and has inner space; With
Interface, it is communicated with described inner space, wherein, the surrounding air of described rigid body outside can to enter in described inner space through described porous material and then during inspiratory event with described orifice, and not to be communicated with by valve.
2. device according to claim 1, is characterized in that, the porous had at least partially between about 5 microns and about 500 microns of porous plastics.
3. device according to claim 1, is characterized in that, the thickness had at least partially between 0.1 to 1.0 inches of porous plastics.
4. device according to claim 1, it is characterized in that, also comprise the box with porous and wall thickness formed by porous material at least in part, described box is communicated with described inner space and is connected to described rigid body, wherein, the porous of described box or wall thickness are different from the porous of described rigid body.
5. device according to claim 1, is characterized in that, also comprises the check valve be communicated with described inner space.
6. increase a method for lung's strength, it comprises:
Obtain porous plastics lung exerciser, it comprises (a) has the rigid body of internal path, (b) is communicated with described internal path interface and (c) at least one porous plastics part;
By described interface air-breathing, make described air-breathing force a part for air through described porous plastics part, thus increase air-breathing strength, wherein, surrounding air and described interface are by porous plastics members.
7. method according to claim 5, is characterized in that, the porous had at least partially between about 5 microns and about 500 microns of described porous plastics.
8. method according to claim 5, is characterized in that, the thickness had at least partially between about 0.1 to 1.0 inches of described porous plastics.
9. method according to claim 5, it is characterized in that, described exerciser also comprises the check valve cooperated with described rigid body, make when exhaling, the walking around described porous plastics part at least partially and flow out described exerciser by described valve of air of breathing out, thus the increase of expiration strength is minimized.
10. method according to claim 5, is characterized in that, described porous plastics part is a part for described rigid body or has the porous box larger than the porous of described rigid body.
11. methods according to claim 5, is characterized in that, user advances at least 100 yards when using described device without hand.
12. 1 kinds of lung's exercising apparatus, comprising:
Rigid body, it is formed by porous plastics at least in part and has inner space; With
Interface, it is communicated with described inner space, wherein, the air sucked by user during inspiratory event is by travelling across described porous plastics to be communicated with the surrounding air of described rigid body outside, and be not communicated with by valve, wherein, user's experience under 1 liter of gettering rate per second is greater than the resistance of the water of 26 inches.
13. devices according to claim 12, it is characterized in that, also comprise the check valve cooperated with described rigid body, wherein, when exhaling, the air of breathing out walk around described porous plastics part at least partially, and flow out described exerciser by described valve, thus the increase of expiration strength minimized.
14. devices according to claim 12, is characterized in that, described rigid body has the weight being less than 5 ounces.
15. devices according to claim 12, is characterized in that, also comprise box, described box has the weight between 0.1 and 1 ounce.
16. devices according to claim 12, is characterized in that, the center of gravity of described device is positioned at the tooth nearside of user.
17. devices according to claim 12, is characterized in that, also comprise dead space and introduce parts.
18. devices according to claim 12, it is characterized in that, also comprise the box be fluidly communicated with described rigid body and the check valve be fluidly communicated with described rigid body, wherein, when exhaling, exhale flow out described exerciser by described valve at least partially, with thus the increase of air-breathing strength is minimized.
19. devices according to claim 12, is characterized in that, also comprise adjustable check valve, and described adjustable check valve has the opening pressure being less than 0.3 psi, is fluidly communicated with described rigid body.
20. 1 kinds of lung's exercising apparatus, it comprises: rigid body, it is formed by porous plastics at least in part, there is the porous between 5 microns and 250 microns and the wall thickness between 0.05 inch and 0.5 inch, wherein, the device body of rigidity is suitable for receiving removedly: (a) interface; (b) at least one following other component are selected from: (1) box, it has the porous between 5 microns and 250 microns and the wall thickness between 0.05 inch and 1 inch, wherein, the porous of described box or wall thickness are different from porous or the wall thickness of described device body, (2) valve, it has the opening pressure being less than 1 psi, and (3) dead space introduces parts.
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US61/721186 | 2012-11-01 | ||
PCT/US2013/054494 WO2014028370A2 (en) | 2012-08-13 | 2013-08-12 | Pulmonary system resistance training apparatus and methods |
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CN105457180A (en) * | 2015-11-25 | 2016-04-06 | 特宁面罩有限公司 | Resistance and filtering breather |
Also Published As
Publication number | Publication date |
---|---|
EP2882504A4 (en) | 2016-11-02 |
WO2014028370A3 (en) | 2015-04-30 |
EP2882504A2 (en) | 2015-06-17 |
AU2013302941A2 (en) | 2015-04-23 |
US20150231443A1 (en) | 2015-08-20 |
AU2013302941A1 (en) | 2015-04-02 |
WO2014028370A2 (en) | 2014-02-20 |
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