CN104857558A - Preparation method for bone cement powder - Google Patents
Preparation method for bone cement powder Download PDFInfo
- Publication number
- CN104857558A CN104857558A CN201510276623.6A CN201510276623A CN104857558A CN 104857558 A CN104857558 A CN 104857558A CN 201510276623 A CN201510276623 A CN 201510276623A CN 104857558 A CN104857558 A CN 104857558A
- Authority
- CN
- China
- Prior art keywords
- preparation
- bone cement
- polymethyl methacrylate
- antibiotic
- cement powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention provides a preparation method for bone cement powder. Raw materials of the bone cement powder include antibiotics. The preparation method comprises the following steps: Step S1, dispersing the raw materials in a solvent to obtain a mixed solution; Step S2, drying the mixed solution. By applying the technical scheme, the antibiotics and other raw materials are dispersed in the solvent to obtain the mixed solution, and then the mixed solution is dried to obtain the bone cement powder; the antibiotics can be uniformly dispersed in the bone cement powder, so that a problem of incapability of releasing the antibiotics due to gathering of the antibiotics at a part in the prior art is solved.
Description
Technical field
The present invention relates to bone cement field, in particular to a kind of preparation method of bone cement powder.
Background technology
Bone cement compositions as the defect portion of bone the bonding agent filled up agent or the bone of the metal artificial jointes such as joint prosthesis and surrounding is fixed etc. and widely use in the whole world, as this bone cement compositions, the most frequently used polymethyl methacrylate (PMMA) pastern bone cement composition.Artificial joint is built-in medical apparatus and instruments, and object resides in osseous tissue for a long time.Once there be a small amount of antibacterial to be successfully stranded in the danger built-in material just having infection in artificial joint replacement.And the pharmacokinetics technical ability of osseous tissue is poor, carrying out Formulations for systemic administration by intravenous injection or oral antibiotic can only affect antibacterial in soft tissue or bone, and the antibacterial be bonded in biomembrane can not be affected.Suppress the medicine least concentration (MIC) of the antibacterial of set to exceed its MIC thousands of times spreading the antibacterial of coming, they receive the protection of biomembrane mechanical barrier.Removing these pathogen needs operation to overhaul, and comprises and thoroughly removes built-in material and antibacterial.Otherwise the antibacterial of set will exist and as deposit, cause Periprosthetic infection and recurrence under appropriate conditions.In these cases, in bone cement, add antibiotic can play treatment and preventive effect.This obtains high antibiotic concentration at infection site and prevents bacterial adhesion in a selection of built-in material surface.
In general, antibiotic adds in the powder in the bone cement compositions that machined, and this makes antibiotic be difficult to be evenly distributed in the powder in cement composition.This may cause antibiotic to be assembled at a certain position, causes antibiotic not discharge.
Summary of the invention
Main purpose of the present invention is the preparation method providing a kind of bone cement powder, causes antibiotic not discharge problem to solve antibiotic in prior art in the gathering of a certain position.
To achieve these goals, according to an aspect of the present invention, provide a kind of preparation method of bone cement powder, the ingredient bags of bone cement powder is containing antibiotic, and preparation method comprises: step S1, batching is scattered in solvent and obtains mixed liquor; Step S2, carries out dried to mixed liquor.
Further, antibiotic is gentamycin sulfate.
Further, batching also comprises polymethyl methacrylate and benzoyl peroxide.
Further, in solvent, the concentration of polymethyl methacrylate is 10 grams and often rises to 20 grams often liter.
Further, polymethyl methacrylate and antibiotic mass ratio are 60 to 100; And/or the mass ratio of polymethyl methacrylate and benzoyl peroxide is 120 to 200.
Further, batching also comprises radiopaque material.
Further, radiopaque material comprises barium sulfate and/or zirconium dioxide.
Further, the mass ratio of polymethyl methacrylate and radiopaque material is 5 to 7.
Further, step S2 comprises and mixed liquor is added spray dryer carries out spraying dry.
Further, the inlet temperature in spray dryer is 30 DEG C to 80 DEG C, and leaving air temp is 20 DEG C to 40 DEG C; And/or the aspiration pressure in spray dryer is 0.5MPa to 5MPa; And/or the velocity of rotation of the peristaltic pump of spray dryer is 10rpm to 100rpm.
Apply technical scheme of the present invention, antibiotic and other batching are dispersed in solvent and obtain mixed liquor, then dried is carried out to mixed liquor and obtain bone cement powder, antibiotic can be evenly dispersed in bone cement powder, solves the antibiotic existed in prior art and assembles at a certain position and cause antibiotic not discharge problem.
Detailed description of the invention
It should be noted that, when not conflicting, the embodiment in the application and the feature in embodiment can combine mutually.The present invention is described in detail below in conjunction with embodiment.
In the present embodiment, the ingredient bags of described bone cement powder is containing antibiotic, and the preparation method of bone cement powder comprises: step S1, batching is scattered in solvent and obtains mixed liquor; Step S2, carries out dried to described mixed liquor.
Antibiotic and other batching are dispersed in solvent and obtain mixed liquor, then dried is carried out to mixed liquor and obtain bone cement powder, antibiotic can be evenly dispersed in bone cement powder, solves the antibiotic existed in prior art and assembles at a certain position and cause antibiotic not discharge problem.
Preferably, described antibiotic is gentamycin sulfate.
In the present embodiment, described batching also comprises polymethyl methacrylate and benzoyl peroxide.The concentration of polymethyl methacrylate described in described solvent is 10 grams and often rises to 20 grams often liter.
Described polymethyl methacrylate and described antibiotic mass ratio are 60 to 100.The mass ratio of described polymethyl methacrylate and described benzoyl peroxide is 120 to 200.
Described batching also comprises radiopaque material.Described radiopaque material comprises barium sulfate and/or zirconium dioxide.The mass ratio of described polymethyl methacrylate and described radiopaque material is 5 to 7.The footpath size of radiopaque material is homogeneous, is 0.1-100 micron.
In the present embodiment, described step S2 comprises and described mixed liquor is added spray dryer carries out spraying dry.Inlet temperature in described spray dryer is 30 DEG C to 80 DEG C, and leaving air temp is 20 DEG C to 40 DEG C; And/or the aspiration pressure in described spray dryer is 0.5MPa to 5MPa; And/or the velocity of rotation of the peristaltic pump of described spray dryer is 10rpm to 100rpm.
In a preferred embodiment in the present embodiment, by polymethyl methacrylate 30 grams, radiopaque material 5 grams of (barium sulfate or Zirconium dioxide powders, size is homogeneous, for 0.1-100 micron), benzoyl peroxide 0.2 gram, antibiotic (gentamycin sulfate 0.4 gram) is dissolved in 500 milliliters of acetone solns, again this solution is added spray dryer to carry out spraying dry and obtain bone cement powder, described spray-dired condition is inlet temperature 30 ~ 80 DEG C, admission pressure is 0.5-5MPa, during leaving air temp 20 ~ 40 DEG C, peristaltic pump rotating speed 10 ~ 100rpm.The bone cement powder that the inventive method is produced, radiopaque material and antibiotic can be evenly distributed in the powder of bone cement compositions, significantly improve mechanical property, and antibiotic is in the release of therapentic part.
The granule size of the bone cement powder that the present embodiment becomes is homogeneous, between 0.1-100 micron.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a preparation method for bone cement powder, the ingredient bags of described bone cement powder is containing antibiotic, and it is characterized in that, described preparation method comprises:
Step S1, is scattered in batching in solvent and obtains mixed liquor;
Step S2, carries out dried to described mixed liquor.
2. preparation method according to claim 1, is characterized in that, described antibiotic is gentamycin sulfate.
3. preparation method according to claim 1, is characterized in that, described batching also comprises polymethyl methacrylate and benzoyl peroxide.
4. preparation method according to claim 3, is characterized in that, the concentration of polymethyl methacrylate described in described solvent is 10 grams and often rises to 20 grams often liter.
5. the preparation method according to claim 3 or 4, is characterized in that,
Described polymethyl methacrylate and described antibiotic mass ratio are 60 to 100; And/or,
The mass ratio of described polymethyl methacrylate and described benzoyl peroxide is 120 to 200.
6. preparation method according to claim 3, is characterized in that, described batching also comprises radiopaque material.
7. preparation method according to claim 6, is characterized in that, described radiopaque material comprises barium sulfate and/or zirconium dioxide.
8. the preparation method according to claim 6 or 7, is characterized in that, the mass ratio of described polymethyl methacrylate and described radiopaque material is 5 to 7.
9. preparation method according to claim 1, is characterized in that, described step S2 comprises and described mixed liquor is added spray dryer carries out spraying dry.
10. preparation method according to claim 9, is characterized in that,
Inlet temperature in described spray dryer is 30 DEG C to 80 DEG C, and leaving air temp is 20 DEG C to 40 DEG C; And/or,
Aspiration pressure in described spray dryer is 0.5MPa to 5MPa; And/or,
The velocity of rotation of the peristaltic pump of described spray dryer is 10rpm to 100rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510276623.6A CN104857558A (en) | 2015-05-26 | 2015-05-26 | Preparation method for bone cement powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510276623.6A CN104857558A (en) | 2015-05-26 | 2015-05-26 | Preparation method for bone cement powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104857558A true CN104857558A (en) | 2015-08-26 |
Family
ID=53904009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510276623.6A Pending CN104857558A (en) | 2015-05-26 | 2015-05-26 | Preparation method for bone cement powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104857558A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773433A (en) * | 2020-07-21 | 2020-10-16 | 北京积水潭医院 | Preparation method of drug-loaded nano-bubble bone cement |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1597590A (en) * | 2004-07-27 | 2005-03-23 | 西南交通大学 | Calcium phoshate bone cement powder containing traditional Chinese medicine and its preparation method |
| CN1836741A (en) * | 2006-02-23 | 2006-09-27 | 北京茵普兰科技发展有限公司 | Micropore bone cement and bone cream |
| WO2012018612A2 (en) * | 2010-07-26 | 2012-02-09 | Warsaw Orthopedic, Inc. | Calcium particle-embedded, snap-to-dough, high-viscosity bone cement |
| CN104511054A (en) * | 2013-09-27 | 2015-04-15 | 上海交通大学医学院附属第九人民医院 | Anti-infection bone cement and preparation method thereof |
-
2015
- 2015-05-26 CN CN201510276623.6A patent/CN104857558A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1597590A (en) * | 2004-07-27 | 2005-03-23 | 西南交通大学 | Calcium phoshate bone cement powder containing traditional Chinese medicine and its preparation method |
| CN1836741A (en) * | 2006-02-23 | 2006-09-27 | 北京茵普兰科技发展有限公司 | Micropore bone cement and bone cream |
| WO2012018612A2 (en) * | 2010-07-26 | 2012-02-09 | Warsaw Orthopedic, Inc. | Calcium particle-embedded, snap-to-dough, high-viscosity bone cement |
| CN104511054A (en) * | 2013-09-27 | 2015-04-15 | 上海交通大学医学院附属第九人民医院 | Anti-infection bone cement and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773433A (en) * | 2020-07-21 | 2020-10-16 | 北京积水潭医院 | Preparation method of drug-loaded nano-bubble bone cement |
| CN111773433B (en) * | 2020-07-21 | 2022-02-08 | 北京积水潭医院 | Preparation method of drug-loaded nano-bubble bone cement |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10420794B2 (en) | Polysaccharide particle mixture | |
| JP5095034B2 (en) | System and calcium phosphate composition for producing post-irradiation storage-stable direct-injectable dual-paste bone cement | |
| JP2002315823A (en) | Antibiotics-polymer combination and use of the same | |
| US9198997B2 (en) | Rehydratable thiolated polysaccharide particles and sponge | |
| Shamma et al. | Design of novel injectable in-situ forming scaffolds for non-surgical treatment of periapical lesions: in-vitro and in-vivo evaluation | |
| JP2013540821A5 (en) | ||
| CN103957949A (en) | Hemostatic compositions | |
| KR20110135944A (en) | Bone cement composition, bone cement composition kit, and method for forming bone cement cured body | |
| US20110112210A1 (en) | Pmma paste | |
| JPWO2009131250A1 (en) | Easy-to-remove dental curable composition | |
| TW201328699A (en) | Pharmaceutical composition useful for adhesion prevention or hemostasis | |
| JP2004097822A (en) | Antibiotic-polymer combined composition and use thereof | |
| CN108992706A (en) | A kind of antibiotic continues acrylic resin bone cement efficiently discharged and preparation method thereof | |
| Chen et al. | An antibacterial and injectable calcium phosphate scaffold delivering human periodontal ligament stem cells for bone tissue engineering | |
| CN104857558A (en) | Preparation method for bone cement powder | |
| JP2004182661A (en) | Pretreating agent for resin-reinforced cement for dentistry | |
| EP2997983A1 (en) | Method for producing an antiobiotic polymethylmethacrylate bone cement powder, and an antibiotic polymethylmethacrylate bone cement powder | |
| CN101485904A (en) | Injectable calcium sulphate-based sustained-release implantation component containing medicine-carrying particle and application | |
| CN106963975B (en) | Bletilla striata gum self-assembly nano particle and preparation method and application thereof | |
| JP4342035B2 (en) | Dental adhesive composition | |
| Kuo et al. | Hydrogel-Based Strategies for the Management of Osteomyelitis | |
| CN104826160B (en) | The preparation method of bone cement pulvis | |
| CN106310357A (en) | Bone filling adhesive and preparation method as well as application of bone filling adhesive | |
| JP4456683B2 (en) | Dental adhesive kit | |
| CN108143720A (en) | Anti-infectious sustained release pharmaceutical composition of biodegradation type hemostasis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150826 |