CN104840475B - Aspirin is used to prepare the purposes of acupuncture point activator - Google Patents
Aspirin is used to prepare the purposes of acupuncture point activator Download PDFInfo
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Abstract
The present invention relates to the new applications that aspirin is used as acupuncture point activator.Aspirin activates acupuncture point by improving the easypro contracting motional amplitude of the self-disciplining through cave area capilary, increases the function of channels and collaterals qi and blood circulation promotion, reaches strengthening vital QI to eliminate pathogenic factors, treat the effect of disease.Compared with existing acupuncture mode, the present invention imports only by acupuncture point or applys aspirin, to play same therapeutic effect of acupuncture, does not need professional personnel and dedicated tool, acupuncture treatment is not needed, adjunct acupuncture points prescription is carried out according to disease disease, property, applies aspirin at acupuncture point, by improving the easypro contracting activity amplitude of acupuncture point area capilary self-disciplining, activate acupuncture point, by the conduction of the affiliated channels and collaterals in acupuncture point, qi and blood is adjusted, thus Yin Yang balancing, the internal organs that reconcile；Significantly improve the sensitivity threshold of microvascular endothelial cells simultaneously, improve its structure and function, it is ensured that flying up and down property substance is in high-order equilibrium state, repair it is unbalance between flying up and down property substance caused by the virulence factor of microvascular endothelial cells, to treat disease.
Description
Technical field
The present invention relates to the new applications of drug, specifically, are related to aspirin for activating acupuncture point, are used as acupuncture point and activate
The new application of agent.
Background technique
Acupuncture point is the qi and blood of zang-fu differentiation at the position that body surface collects, is transfused, and is one of Chinese medicine traditional treatment mode ---
The stimulation point of acupuncture.
The result of study of tectology shows that the generally existing structure in acupuncture point area is felt nerve endings, vegetative nerve
Terminal, mast cell and capilary, and the generally existing and relative abundance of capilary is that other three kinds of structures exist simultaneously and rich
Rich basis.Mu Xiang etc. has found the abundant in the presence of the material base for being acupuncture point of capilary.
There is capilary the easypro contracting activity of self-disciplining early to have been found and confirm.The early-stage studies such as Mu Xiang find and confirm:
The intracutaneous capilary group in acupuncture point area, which has, synchronizes the movable function of contracting of relaxing, and in the sinusoidal waveform of rule, is substantially distinguished from non-cave
Position area；Capilary group easypro contracting motion frequency having the same on same passages through which vital energy circulates between different acupuncture points, in skin；Difference warp
Between acupuncture point on arteries and veins, the easypro movable frequency of contracting of capilary group in skin is not identical.
About acupuncture on the easypro movable influence of contracting of capilary group's self-disciplining in acupuncture point area skin, the discovery of the early-stage studies such as Mu Xiang
And confirm: stimulating acupuncture point using the methods of needle thorn and moxa-moxibustion, can not only significantly improve capilary group in stimulated acupuncture point area skin
Self-disciplining is relaxed the movable amplitude of contracting, and can also significantly improve with acupuncture point areas other on the same passages through which vital energy circulates in stimulated acupuncture point and with pierced
Swash the easypro movable amplitude of contracting of capilary group's self-disciplining in the acupuncture point area skin of the same name of acupuncture point body opposite side, is remarkably improved and is pierced
Blood flow through the adjacent focal zone of passages through which vital energy circulates where pulse-phase network category internal organs and stimulated acupuncture point where swashing acupuncture point.The early periods such as Mu Xiang into
The research of one step finds and confirms: blocking the easypro contracting activity of capilary group's self-disciplining in skin, then can block needle thorn or moxa-moxibustion thorn
Above-mentioned variation after swashing shows that the raising of the easypro contracting activity amplitude of capilary group's self-disciplining in acupuncture point area skin is the pass of acupuncture effect
Keyness will mark.
About the mechanism for improving the easypro contracting activity amplitude treatment disease of capilary self-disciplining, the blood in addition to improving tissue is supplied
Should be outer, the early-stage studies such as Mu Xiang find and confirm: after improving the easypro contracting activity amplitude of capilary self-disciplining, can significantly improve capilary
The sensitivity threshold of endothelial cell；The structure and function that microvascular endothelial cells can be significantly improved is allowed to preferably maintain cell
Environment；It can be using expansion angiogenic substance and vaso-excitor material that microvascular endothelial cells is secreted as information substance, it is ensured that cell peripheral
Flying up and down property substance be in high-order equilibrium state, thus unbalance between repairing flying up and down property substance caused by virulence factor.
It relaxes the curative effect of contracting movable amplitude and acupuncture about capilary group's self-disciplining in acupuncture point area skin is improved, before Mu Xiang etc.
Phase research find simultaneously confirm: in human trial, needle thorn, moxa-moxibustion when, capilary group's self-disciplining relax contracting activity amplitude raising frequency
Secondary to be positively correlated with curative effect, i.e., in 10 treatments, the easypro contracting activity amplitude of capilary group's self-disciplining improves 8 times or more persons are treated
Effect is significantly higher than 8 times or less persons, and raising 6 times or more persons are significant in efficacy to be higher than 6 times or less persons；In animal experiment, skin is blocked
The easypro contracting activity of capilary group self-disciplining in skin, then needle thorn or moxa-moxibustion inefficacy.Show the easypro contracting activity vibration of capilary group's self-disciplining
The raising of width is the key mark of therapeutic effect of acupuncture, it can be considered that acupuncture by improve capilary relax the movable amplitude of contracting with
Increase the function of channels and collaterals qi and blood circulation promotion to have the function that treat disease.
Currently, application of acupuncture is in the clinically treatment of numerous diseases and significant in efficacy, still, because the application of acupuncture and moxibustion treatment needs
Professional personnel and dedicated tool are wanted, this brings inconvenience to the treatment of patient.And usually patient can be to acupuncture treatment
There is certain fear, some patients even have the symptom having a fainting spell during acupuncture treatment appearance.
Huangdi's Internal Classics are " medicine administered by injection is homologous " on the books, acupuncture Chinese medicine, though be divided into it is outer control, it is interior control, medicine administered by injection is homologous, controls also
Similarly.Two kinds for the treatment of skills are even more effectively combined, are widely used in clinic from ancient times to the present by point medicine.Acupuncture point can be used as to
Medicine window, absorbs the drug, and generates therapeutic effect.The inventors discovered that acupoint iontophoresis or utilizing patch by ion introducing apparatus
The easypro contracting amplitude of the intradermal capilary in cave area can be significantly improved by applying method point-application aspirin, reach the curative effect of same acupuncture.
To sum up, the new application of aspirin is proposed.
Summary of the invention
The object of the present invention is to provide the new applications of aspirin.
Aspirin is also acetylsalicylic acid, is common analgesic-antipyretic, can be used for curing cold, generate heat, having a headache, tooth
Bitterly, arthralgia, rheumatism, moreover it is possible to inhibit platelet aggregation, for preventing and treating ischemic heart disease, angina pectoris, cardiopulmonary stalk
Plug, cerebral thrombosis, are applied to revascularization and bypass grafting is also effective.
Through research, the inventor has found that aspirin can be used as acupuncture point activator application.
Acupuncture is a kind of most commonly seen acupuncture point active mode, and existing result of study confirms that acupuncture can not only significantly improve
The easypro movable amplitude of contracting of capilary group's self-disciplining in stimulated acupuncture point area skin, and can also significantly improve same with stimulated acupuncture point
Capilary group's self-disciplining is relaxed contracting in other acupuncture point areas and the acupuncture point area skin of the same name with stimulated acupuncture point body opposite side on one passages through which vital energy circulates
Movable amplitude.
Experimental studies have found that applying aspirin at acupuncture point, micro- blood in stimulated acupuncture point area skin can be also significantly improved
The easypro movable amplitude of contracting of nest of tubes self-disciplining, while significantly improving the capilary with acupuncture point areas other on the same passages through which vital energy circulates in stimulated acupuncture point
The easypro movable amplitude of contracting of group's self-disciplining.Obviously, aspirin can activate acupuncture point as acupuncture point activator.
The aspirin can be improved the easypro contracting activity amplitude of self-disciplining of cave area capilary, activate acupuncture point.
Aspirin can be effectively improved simultaneously restrains oneself with the capilary in acupuncture point areas other on the same passages through which vital energy circulates in stimulated acupuncture point
Property relax contracting activity amplitude, activation acupuncture point.
Existing result of study shows that the raising of the easypro contracting activity amplitude of capilary group's self-disciplining in acupuncture point area skin is acupuncture
The key mark of effect.Further, after improving the easypro contracting activity amplitude of capilary self-disciplining, microvascular endothelial can be significantly improved
The sensitivity threshold of cell；The structure and function that microvascular endothelial cells can be significantly improved is allowed to preferably maintain the environment of cell；
It can be using expansion angiogenic substance and vaso-excitor material that microvascular endothelial cells is secreted as information substance, it is ensured that cell peripheral is flied up and down
Property substance be in high-order equilibrium state, thus unbalance between repairing flying up and down property substance caused by virulence factor.
Therefore, the present invention is reacted by the experiment of the variation of the easypro contracting activity amplitude of self-disciplining of acupuncture point area capilary to cave
The stimulation of position, it was demonstrated that aspirin has activation to acupuncture point, can be used as the use of acupuncture point activator.
Obviously, it is based on above-mentioned discovery, the aspirin can be used for preparing acupoint activation drug.
By application aspirin in corresponding acupuncture point, aspirin is by improving the easypro contracting activity vibration of capilary self-disciplining
Width improves the blood supply of tissue, while the easypro contracting activity amplitude of the capilary self-disciplining that can also improve same meridian point, activation
Acupuncture point, dredging the channel, regulating the qi flowing in the channels blood make yin-yang be attributed to opposite balance, and viscera function is made to tend to reconcile, to reach disease preventing and treating
Purpose.
Method of administration the present invention also provides aspirin as acupuncture point activator.
The aspirin can be applied by ion introducing apparatus or plaster application method.
It is demonstrated experimentally that application aspirin, in corresponding acupuncture point, the self-disciplining that can significantly improve acupuncture point area capilary is relaxed
Contract movable amplitude, activates acupuncture point, additionally it is possible to be conducted by channels and collaterals, improve the easypro contracting activity of capilary self-disciplining with meridian point
Amplitude.
It is described that apply aspirin by ion introducing apparatus be that aspirin solution is applied to cave using ion introducing apparatus
Position.
Wherein, the ion introducing apparatus leads medicine time 2min, leads medicine electric current 0.2mA；The aspirin is aqueous solution；
The concentration of the aspirin aqueous solution is 1mg/mL；Each acupuncture point import volume 200ul.
The plaster application method application aspirin is the plaster that aspirin is configured to aspirin content and is 2%,
It is uniformly applied on the non-woven fabrics of appropriate size, sticks on corresponding acupuncture point.
The corresponding site of specific each channels and collaterals can be found in Chinese medicine commonly various rudimentary knowledge and teaching material.By aspirin
It is applied to acupuncture point, acupuncture effect can be reached, the easypro contracting activity amplitude of the cave area microvascular endothelial cells is improved, activates the cave
Position, by the conduction of its affiliated channels and collaterals, further activation is located at the acupuncture point for belonging to Same Meridian of focal zone, improves focal zone
The blood supply of tissue；The sensitivity threshold for improving focal zone microvascular endothelial cells, improves the structure and function of endothelial cell, makes
Preferably maintain cell environment；Ensure that the flying up and down property substance of cell peripheral is in high-order equilibrium state simultaneously, to repair
It is unbalance between flying up and down property substance caused by virulence factor.
New application the invention proposes aspirin as acupuncture point activator, compared with existing therapeutic method of acupuncture and moxibustion,
At acupuncture point, application aspirin can reach acupuncture effect, but pierce without needle, and personnel and dedicated tool without profession are described
New application can make aspirin be applied to play the curative effect with acupuncture at activation acupuncture point.
Detailed description of the invention
Fig. 1 is the delta data system that acupuncture point imports aspirin and the easypro contracting activity amplitude of physiological saline process cave area's capilary
Meter figure；Wherein, note: before leading medicine compared with Hepatic Perfusion amount, " * * " indicates P < 0.01.
Fig. 2 is the delta data statistical chart that medicine process Hepatic Perfusion amount (PU) is led at acupuncture point；Wherein, note: before leading medicine
Hepatic Perfusion amount compares, and " * " indicates P < 0.05.
Fig. 3 is the delta data of the easypro contracting activity amplitude of ququan acupoint capilary before and after intramuscular injection aspirin and physiological saline
Statistical chart.
Fig. 4 is the delta data statistics of Hepatic Perfusion amount (PU) before and after intramuscular injection aspirin and physiological saline
Figure.
Fig. 5 point-application aspirin and physiological saline, the easypro movable delta data statistical chart of contracting of ququan acupoint capilary.Its
In, note: before leading medicine compared with Hepatic Perfusion amount, " * * " indicates P < 0.01.
Specific embodiment
The invention will now be further described with reference to specific embodiments, but examples are merely exemplary, not to this hair
Bright range constitutes any restrictions.It will be understood by those skilled in the art that without departing from the spirit and scope of the invention
Can with the details and forms of the technical scheme of the invention are modified or replaced, but these modification and replacement each fall within it is of the invention
In protection scope.
Based on existing result of study, after the present embodiment is using cave area application drug, acupuncture point area capilary self-disciplining, which is relaxed, to contract
Whether whether activity amplitude is significantly increased to judge whether the drug has activation to acupuncture point, i.e., can activate as acupuncture point
Agent application.
Due to the area very little that there is the capilary group of synchronous systolic and diastolic function to occupy in acupuncture point area, and it is now widely used in measurement
The probe of the laser Doppler flowmetry of capilary mechanics only 0.25mm, therefore traditionally determining acupuncture point, are detected
The easypro movable probability of contracting of capilary group synchronization is very low.The present embodiment combination acupuncture point low resistance characteristic, uses laser-Doppler blood flow instead
Perfusion Imaging instrument relaxes and contracts to measure the easypro contracting mechanics of the intradermal capilary in acupuncture point and same passages through which vital energy circulates Different Acupoint capilary self-disciplining
Motion conditions.
1 aspirin of embodiment, which is applied to knee and closes cave, relaxes the effect of the movable amplitude of contracting and right to Yongquan acupoint capilary
The influence of the blood perfusion amount of liver
1 materials and methods
1.1 test material
1.1.1 experimental animal and grouping
According to administration mode and the difference of drug, the male SD rat of 40 180~200g is randomly divided into 4 groups: acupuncture point
Medicine group is led, aspirin and physiological saline are directed respectively into；Intramuscular injection group, injection leads identical dose of medicine group with corresponding acupuncture point respectively
The aspirin and physiological saline of amount, concentration.
1.1.2 key instrument equipment and reagent are using common various instruments and reagent, and wherein aspirin standard items are (pure
Degree > 98%；National Institute for Food and Drugs Control)
1.1.3 Chinese medicine, solution are prepared
Precision weighs aspirin standard items 1mg, and 1mL physiological saline is added, the aspirin solution of 1mg/mL is made.
1.2 test method
1.2.1 the preparation of experimental animal
Rat acupuncture point area to be measured shifts to an earlier date at least one day defeathering, and when defeathering avoids damage to skin.First induced anesthesia, flesh before test
Meat injects 0.1mL atropine sulfate, then gives rats by intraperitoneal injection yellow Jackets according to the dosage of 20mg/mL, 30mg/kg,
It anaesthetizes sb. generally, in case test.
1.2.2 the selection of monitoring object
The ququan acupoint in the rat liver channel of foot-Jueyin is chosen as monitoring acupuncture point, leads medicine acupuncture point with being used as through upper knee pass cave,
It is avoided around ququan acupoint at Meridian lines, acupuncture point, blood vessel and skin injury as intramuscular injection point.After experimental animal holonarcosis,
Cave and surrounding skin are closed with 75% cotton ball soaked in alcohol cleaner assay animal ququan acupoint, knee, after alcohol volatilization, acupuncture point is positioned
And it marks.
Selected liver is another monitoring object, and building can avoid the abdominal cavity access of body surface meridians but also exposure liver.?
It is other on the right side of midline abdominal to open at 0.5cm, it does the vertical notch of a long 3cm downwards from ensiform process of sternum, liver is completely exposed, in liver
Underlay impregnated the gauze piece of physiological saline well to keep wet.
The blood perfusion amount of right siphonal lobe lobuli hepatis is monitored respectively using laser-Doppler perfusion weighted imaging instrument and foot is fainted yin
The parameters such as the capilary self-disciplining of ququan acupoint easypro contracting motion frequency, amplitude on Liver Channel.
1.2.3 medicine group is led at acupuncture point
After laser-Doppler perfusion weighted imaging system warm-up 10min, cave, ququan acupoint are closed according to anatomy position monitor knee
Cave area capilary relaxes contracting activity, and such as the frequency of occurrences and the irregular map of amplitude, then appropriateness adjustment monitoring point, guarantees the accurate of acupoint selection
Property, and record the easypro contracting activity 5min of ququan acupoint capilary.
It is drawn on the 1mg/mL aspirin solution injection iontophoresis electrode liner of 200 μ L with micropipettor later, it will be from
The medicine-introducing electrode of sub- introducing apparatus is fixed on knee and closes cave, opens PF382 power supply, and setting leads medicine time 2min, leads medicine electric current 0.2mA,
It leads medicine and continues to monitor ququan acupoint in the process, continue to monitor ququan acupoint 10min after leading medicine.
Ibid, 0.9% physiological saline that cave imports 200 μ L is closed in knee, records and saves acupuncture point and leads in medicine complete procedure
The blood perfusion amount of the easypro contracting activity map of ququan acupoint capilary and liver.
1.2.4 intramuscular injection group
After laser-Doppler perfusion weighted imaging system warm-up 10min, according to the micro- blood in anatomy position monitor ququan acupoint area
Contracting activity of relaxing is managed, such as the frequency of occurrences and the irregular map of amplitude, then appropriateness adjustment monitoring point, guarantees the accuracy of acupoint selection, and remember
Record the easypro contracting activity 5min of ququan acupoint capilary.
The 1mg/mL aspirin solution of 200 μ L, the Non-acupoints around ququan acupoint are drawn with 1mL disposable syringe
White space carries out intramuscular injection, continues to monitor ququan acupoint 10min later.
Ibid, around ququan acupoint the 200 μ L of white space intramuscular injection of Non-acupoints 0.9% physiological saline, record
And save the easypro contracting activity map of the ququan acupoint capilary during intramuscular injection and Hepatic Perfusion amount.
1.2.5 image procossing and data analysis
Led in medicine group at acupuncture point, from each experimental animal lead medicine before, during and after capilary relax contracting activity amplitude image in distinguish
It chooses the calculating of 5 segment datas and leads cave area mean value of amplitude and amplitude variations amplitude before, during and after medicine.Meanwhile entirely leading guarantor during medicine
The monitoring to Hepatic Perfusion amount is held, statistics leads the average value of Hepatic Perfusion amount before, during and after medicine.
Similarly, in intramuscular injection group, from the easypro contracting activity amplitude image of each forward and backward capilary of experimental animal intramuscular injection
The calculating of 5 segment datas is chosen respectively and leads the forward and backward cave area mean value of amplitude of medicine and amplitude variations amplitude, and counts liver blood before and after intramuscular injection
The average value of purling fluence.
(in, rear) amplitude=(PUmax-PUmin)/5 before leading medicine
Mean value of amplitude-leads mean value of amplitude before medicine after amplitude variations amplitude=lead medicine.
With prism statistics software handle data, measurement data with means standard deviation (It indicates, comparison among groups
It is examined with t, is that statistical difference is significant with P < 0.05, P < 0.01 is that statistical difference is extremely significant.
2 results
Lead medicine group in 2.1 acupuncture points
Table 1 is all foot respectively after knee closes cave importing aspirin and physiological saline the results show that compared with leading before medicine
The easypro contracting amplitude of the ququan acupoint area Dermal microvessel on negative Liver Channel of fainting has different degrees of variation, and wherein cave area imports aspirin
Compared with importing physiological saline, intradermal capilary is improved extremely significantly and relaxes contracting activity amplitude (P < 0.01) (see Fig. 1).By table 2
As it can be seen that being remarkably improved Hepatic Perfusion amount (P < after importing aspirin in the liver channel of foot-Jueyin compared with leading before medicine
0.05).(see Fig. 2)
1 acupuncture point of table lead medicine process ququan acupoint capilary relax contracting activity amplitude compare (N=10)
Note: with lead Amplitude Comparison before medicine,1)P < 0.01
2 acupuncture point of table lead medicine process Hepatic Perfusion amount (PU) variation (N is=10)
Note: before leading medicine compared with Hepatic Perfusion amount, 2) P < 0.05
2.2 intramuscular injection groups
Intramuscular injection aspirin and physiological saline are distinguished in Non-acupoints area as shown in Table 3, compared with before injection, injection
Afterwards ququan acupoint capilary relax contracting amplitude there are no significant change (P > 0.05) (see Fig. 3).Meanwhile it injecting front and back liver blood flow and filling
Fluence also there are no significant variation (P > 0.05) (see Fig. 4).
Before and after table 3 intramuscular injection ququan acupoint capilary relax contracting activity amplitude compare (N is=10)
Before and after table 4 intramuscular injection Hepatic Perfusion amount (PU) variation (N is=10)
Embodiment 2 makes aspirin plaster by oneself and is applied to influence of the knee pass cave to the easypro contracting activity amplitude of Yongquan acupoint capilary
1 materials and methods
1.1 test material
1.1.1 experimental animal and grouping
According to administration mode and the difference of drug, by the male SD rat of 20 180~200g be randomly divided into test group and
Two groups of control group.
1.1.2 key instrument equipment and reagent
With embodiment 1
1.1.3 plaster sample preparation
A certain amount of aspirin standard items are taken, is added in the ointment bases that a certain amount of water-bath is dissolved, stirs evenly, be made 2%
Aspirin plaster.Compare plaster normal saline.
1.2 test method
1.2.1 the preparation of experimental animal
With embodiment 1
1.2.2 the selection of monitoring object
With embodiment 1
1.2.3 point-application plaster
Acupuncture point is chosen and operating method is the same as example 1
After accurate acupoint selection, the easypro contracting activity 5min of record ququan acupoint capilary.Aspirin and the life of phase homogenous quantities are taken later
Reason salt water self-control plaster is uniformly applied on the non-woven fabrics of appropriate size, and the knee for being affixed on test group and control rats respectively closes
Plaster is thrown off after 30min in cave, continues to monitor ququan acupoint 10min.
1.2.4 image procossing and data analysis
With embodiment 1
2 results
Table 5 closes cave in knee and sticks aspirin and physiological saline cream the results show that compared with not pasting before aspirin plaster
After medicine, be all that ququan acupoint area Dermal microvessel in the liver channel of foot-Jueyin contracting amplitude that relaxes has different degrees of variation, wherein paste Ah
A woods plaster is taken charge of compared with paste physiological saline plaster, extremely significant to improve in the area of cave capilary easypro contracting activity amplitude (P < 0.01)
(see Fig. 5).
On 5 acupoint plaster of table behind acupuncture point ququan acupoint capilary relax contracting activity amplitude compare (N=10)
Note: with stick preceding Amplitude Comparison,2)P < 0.01
Obviously, above-described embodiment proves that aspirin can significantly improve the easypro contracting activity vibration of acupuncture point area capilary self-disciplining
Width improves and the easypro contracting activity amplitude of the capilary self-disciplining in other acupuncture point areas on the same passages through which vital energy circulates in stimulated acupuncture point, the related warp of raising
There is physiological reaction identical with application acupuncture, that is, same acupuncture effect occur in the blood flow of network correlation internal organs, subjects.
Obviously, experiments have shown that application aspirin can activate acupuncture point, to reach the curative effect of same acupuncture；Aspirin can be made
For the use of acupuncture point activator.
Claims (4)
1. aspirin is in the purposes of preparation acupuncture point activator drug, which is characterized in that specifically: precision weighs aspirin mark
Quasi- product 1mg is added 1mL physiological saline, the aspirin solution of 1mg/mL is made；The 1mg/ of 200 μ L is drawn with micropipettor
ML aspirin solution is injected on iontophoresis electrode liner, and the medicine-introducing electrode of ion introducing apparatus is fixed on knee and closes cave, opens PF382
Power supply, setting lead medicine time 2min, lead medicine electric current 0.2mA, lead medicine and continue to monitor ququan acupoint in the process, continue to supervise after leading medicine
Survey ququan acupoint 10min.
2. purposes as described in claim 1, which is characterized in that the aspirin drug can improve cave area capilary self-disciplining
Relax contracting activity amplitude.
3. aspirin is in the purposes of preparation acupuncture point activator plaster, which is characterized in that specifically: take a certain amount of aspirin mark
Quasi- product are added in the ointment bases that a certain amount of water-bath is dissolved, stir evenly, and 2% aspirin plaster is made；After accurate acupoint selection, note
Record the easypro contracting activity 5min of ququan acupoint capilary；The aspirin and physiological saline self-control plaster for taking phase homogenous quantities later are uniformly smeared
Cave is closed in the knee on the non-woven fabrics of appropriate size, being affixed on test group and control rats respectively, plaster is thrown off after 30min, continues
Monitor ququan acupoint 10min.
4. purposes as claimed in claim 3, which is characterized in that the aspirin cream object can improve cave area capilary self-disciplining
Relax contracting activity amplitude.
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| CN201510135034.6A CN104840475B (en) | 2015-03-26 | 2015-03-26 | Aspirin is used to prepare the purposes of acupuncture point activator |
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|---|---|---|---|
| CN201510135034.6A CN104840475B (en) | 2015-03-26 | 2015-03-26 | Aspirin is used to prepare the purposes of acupuncture point activator |
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| JPH1112177A (en) * | 1997-06-25 | 1999-01-19 | Teikoku Seiyaku Co Ltd | Stable aspirin-containing preparation for external use |
| CN103054965B (en) * | 2013-02-01 | 2014-06-18 | 张冠军 | External analgesic plaster for treating arthralgia and preparation method of external analgesic plaster |
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