CN104840268B - Fixing device for vena caudalis injection of mouse and using method thereof - Google Patents
Fixing device for vena caudalis injection of mouse and using method thereof Download PDFInfo
- Publication number
- CN104840268B CN104840268B CN201510290587.9A CN201510290587A CN104840268B CN 104840268 B CN104840268 B CN 104840268B CN 201510290587 A CN201510290587 A CN 201510290587A CN 104840268 B CN104840268 B CN 104840268B
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- cylinder
- mouse
- fixing
- fixing cylinder
- fixing device
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- 238000002347 injection Methods 0.000 title claims abstract description 30
- 239000007924 injection Substances 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title abstract description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229910052742 iron Inorganic materials 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 7
- 229910000831 Steel Inorganic materials 0.000 claims description 2
- 230000002745 absorbent Effects 0.000 claims description 2
- 239000002250 absorbent Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 239000010959 steel Substances 0.000 claims description 2
- 241000699670 Mus sp. Species 0.000 abstract description 18
- 241000699666 Mus <mouse, genus> Species 0.000 abstract description 15
- 240000003186 Stachytarpheta cayennensis Species 0.000 abstract description 6
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 abstract description 6
- 235000009161 Espostoa lanata Nutrition 0.000 abstract description 5
- 240000001624 Espostoa lanata Species 0.000 abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 5
- 238000002955 isolation Methods 0.000 abstract description 3
- 210000003462 vein Anatomy 0.000 description 5
- 241000581650 Ivesia Species 0.000 description 4
- 230000013872 defecation Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Catching Or Destruction (AREA)
- Eye Examination Apparatus (AREA)
Abstract
The present invention relates to a kind of fixing device for vena caudalis injection of mouse and using method thereof, including holder and object stage;Holder comprises fixing cylinder and Magnet fixed bin, and fixing cylinder comprises slit, ring segment and cylinder door;One end of fixing cylinder is vertical with Magnet fixed bin to be connected, and the other end has cylinder door, and cylinder door has spy uropore；The built-in square magnet block of fixed bin；Setting slit on fixing cylinder, set ring segment in fixing cylinder, ring segment moves through nut along slit and the screw rod through slit is connected with fixing cylinder.The present invention is possible not only to the size of the fixing cylinder of height regulation according to mice, and can be adsorbed on (isolation wall, refrigerator, mouse cage frame etc.) in any iron content plane and use, also can arbitrarily regulate height and the anglec of rotation, find optimum position, shorten the distance between rat-tail and human eye, improve the success rate of injection.Additionally, holder is also equipped with the object stage of collaborative use, facilitate taking of the article such as syringe, cotton ball soaked in alcohol.
Description
Technical field
The present invention relates to a kind of test animal fixing device, particularly relate to a kind of fixing device for vena caudalis injection of mouse and
Its using method.
Background technology
Mouse tail vein injection is usually used in drug screening, acute toxicity test.Traditional mouse tail vein injection holder
Mostly be one end with opening and can close, cylindrical shape that the other end can be breathed freely.During injection, mice is filled in cylindrical shape, will circle
Tubular one end is closed, by this end with opening expose the tail of mice and carry out tail vein injection, also have some modified forms can
With the space according to the fixing cylinder of mice height regulation.But, current mouse tail vein injection holder there is also following shortcoming
(illustrating as a example by the fixing device that Chinese patent CN102451046A announces):
A. trouble is used.First to open engaging part, to turn on nut, take off movable part, mice be upside down and draw in fixed chamber,
It is loaded on movable part, fastening nut, then shuts engaging part, complex operation, waste time and energy.
B. difficult cleaning.Mice defecation is inside holder, and is difficult to inside holder clear up, easy to be dirty smelly.
C. underaction.Holder can only keep flat on the table, and operator is sitting on stool use, does not has a stool at some
Animal Lab. just cannot use, and lacks motility；And lie on desk use, highly, angle the most unadjustable, human eye
Farther out and caudal vein is in side for distance rat-tail, brings inconvenience to injection.
The most perishable, on the high side.Currently marketed mouse fixing device is based on transparent plastics material, and plastic material is inadequate
Solid, especially engaging part, screw rod and movable part junction and some seams etc., have more than is needed the most just break down；Sell
Valency is typically at about 300 yuans, on the high side.
Summary of the invention
It is an object of the invention to provide a kind of new fixing device for vena caudalis injection of mouse and using method thereof, can be to solve
Certainly the problems of the prior art.The present invention is possible not only to the size of the height regulation fixing cylinder according to mice and is securely fixed by mice
Live, and can be adsorbed on (isolation wall, refrigerator, mouse cage frame etc.) in any iron content plane and use；Also can arbitrarily regulate height and
The anglec of rotation, finds optimum position, shortens the distance between rat-tail and human eye, improve the success rate of injection；Mice defecation
Holder can be dropped out by visiting uropore, facilitate the cleaning of holder.Additionally, holder is also equipped with the object stage of collaborative use, side
Just the taking of the article such as syringe, cotton ball soaked in alcohol.
The present invention provides a kind of new fixing device for vena caudalis injection of mouse to include: holder and object stage.
Described holder comprises fixing cylinder and Magnet fixed bin, and fixing cylinder comprises slit, ring segment and cylinder door;Fixing cylinder
One end vertical with Magnet fixed bin be connected, the other end has cylinder door, and cylinder door has spy uropore；The built-in square magnet block of fixed bin；
Set slit on fixing cylinder, in fixing cylinder, set ring segment, ring segment along slit move through nut and through slit screw rod with
Fixing cylinder connects.
The built-in square magnet block of described object stage, into a single integrated structure with Magnet fixed bin, the table top outermost of object stage
There is an eaves.
Described ring segment central authorities are porose.
The area of described ring segment medium pore is the 1/8-1/4 of described annular iron plate.
Described nut is winged structure.
Described cylinder door is folded by left side and fixes cylinder and is connected, realizes closedown by hook and hook ring with fixing cylinder and ties
Structure.
There is spy uropore described cylinder door lower end, is stretched out from visiting uropore by mousetail, and mice hip are close to visit uropore, mice
Defecation is discharged to holder from visiting uropore.
Described hook is fixed on the right side of described cylinder door, and described hook ring is fixed on the right side of fixing cylinder.
Described holder and described object stage material are rustless steel, and described fixing cylinder, described countertop segment
Material is thick, and the material of described Magnet fixed bin part is thinner.
Described Magnet fixed bin is rougher with the contact surface granule of absorbent bodies, and frictional force is big.
Described object stage, on the right side of described holder, coordinates described holder to use.
The present invention provides the step that the using method of a kind of fixing device for vena caudalis injection of mouse includes:
1) first adsorbing at iron content metope, refrigerator or mouse cage frame body surface by holder, regulation height is the most comfortable to oneself
Position.
2) object stage is absorbed and fixed on the right side of holder, and injection utensil syringe, cotton ball soaked in alcohol are placed on loading table top.
3) being left on by fixing cylinder door, mice is put into fixing cylinder, tail stretches out from visiting uropore, is then inserted by hook
Enter the hook ring on fixing cylinder, close cylinder door.
4) ring segment position to applicable mice size is moved in the direction along slit, rotates nut and makes it fix.
5) rotational fixture obtains optimal injection angle, and left hand is tightly caught hold of rat-tail and prevented it from shaking, and the right hand takes syringe
Inject.
Fixing device for vena caudalis injection of mouse disclosed in this invention, is possible not only to the fixing cylinder of height regulation according to mice
Size mice is securely fixed, and can be adsorbed in any iron content plane (isolation wall, refrigerator, mouse cage frame etc.) and make
With；Also can arbitrarily regulate height and the anglec of rotation, find optimum position, shorten the distance between rat-tail and human eye, improve note
The success rate penetrated；Mice defecation can drop out holder by visiting uropore, facilitates the cleaning of holder.Additionally, holder is also joined
There is the object stage of collaborative use, facilitate taking of the article such as syringe, cotton ball soaked in alcohol.
Accompanying drawing explanation
Fig. 1 is the overall composition structure chart of the present invention.
Fig. 2 is that the present invention fixes cylinder annular chip architecture schematic diagram.
Fig. 3 is overall structure floor map of the present invention.
Fig. 4 is overall structure profile axonometric chart of the present invention.
Fig. 5 is object stage generalized section of the present invention.
Fig. 6 is another generalized section of object stage of the present invention.
In figure: 1. Magnet fixed bin opening, 2. Magnet, 3. Magnet fixed bin, 4. band wing nut, 5. screw rod, 6. fold,
7. visiting uropore, 8. fix cylinder door, 9. hook, 10. hook ring, 11. fix cylinder, 12. annular iron plates, 13. slits, 14. object stages
Table top；15 loading table top table eaves, 16 object stage fixed bins, the 17 built-in Magnet of object stage fixed bin.
Detailed description of the invention
By the following specific examples further illustrate the invention, it should be appreciated that the invention is not limited in following
Embodiment.
The present invention provides a kind of new fixing device for vena caudalis injection of mouse to include: holder and object stage;
Described holder comprises fixing cylinder 11 and Magnet fixed bin 3, and fixing cylinder 11 comprises slit 13, ring segment 12 and cylinder door
8;One end of fixing cylinder 11 is vertical with Magnet fixed bin 3 to be connected, and the other end has cylinder door 8, and cylinder door 8 has spy uropore 7；Fixed bin 3
Built-in square magnet block 2；Setting ring segment 12 in fixing cylinder 11, ring segment 12 moves through nut 4 and through slit along slit
The screw rod 5 of 13 is connected with fixing cylinder 11；The described built-in square magnet block of object stage fixed bin, into a single integrated structure with Magnet fixed bin
(right angle setting), the table top outermost of object stage has an eaves 15.
Holder and the collaborative use of object stage, annular (ferrum) sheet 12 is central porose, puts into fixing cylinder 11 by slit 13,
90-degree rotation makes it be parallel to fixing cylinder door 8, and the screw rod 5 by nut 4 with through slit 13 is connected with fixing cylinder 11；Fixing
Cylinder door 8 realizes closing structure by hook 9 and hook ring 10 with fixing cylinder 11.Object stage table top 14 is fixed on the right side of holder,
It is preferably the planar structure of band table eaves；The built-in Magnet of object stage fixed bin 16() it is integrated with loading table top 14.
The critical piece of fixing device for vena caudalis injection of mouse disclosed in this invention is made up of stainless steel material.
During operation, first by holder absorption at body surfaces such as iron content metope, refrigerator, mouse cage framves, regulation height is to oneself
Comfortable position (holder should be close proximity to eyes)；Object stage is absorbed and fixed at the (skill for lefthanded on the right side of holder
Art person can be placed on left side), syringe, cotton ball soaked in alcohol etc. are placed on object stage, conveniently take.Fixing cylinder door 8 is left on,
Mice puts into fixing cylinder 11, and tail stretches out from visiting uropore 7, then by the hook ring 10 on the hook 9 fixing cylinder of insertion by cylinder door 8
Close, move annular (ferrum) sheet 12 position to applicable mice size along the direction of slit 13, rotate nut 4 and make it fix；
Rotational fixture obtains optimal injection angle, and left hand is tightly caught hold of rat-tail and prevented it from shaking, and the right hand takes syringe and injects.
The preferred embodiments of the present invention are had been described in detail above, but the present invention is not limited to these embodiments, in the present invention
Application range in can carry out various change.Although the most simply illustrating the preferred embodiments of the present invention, but, institute
Belong to those skilled in the art to will be apparent from the range of substantially without departing from the novel teachings of the present invention and advantage, permissible
Exemplary embodiment is carried out various amendment.
Claims (9)
1. a fixing device for vena caudalis injection of mouse, it is characterised in that it includes holder and object stage;
Described holder comprises fixing cylinder and Magnet fixed bin, and fixing cylinder comprises slit, ring segment and cylinder door;One end of fixing cylinder
Vertical with Magnet fixed bin being connected, the other end has cylinder door, and cylinder door has spy uropore；The built-in square magnet block of fixed bin；Fixing cylinder
On set slit, set ring segment in fixing cylinder, ring segment moves through nut and through the screw rod of slit and fixing cylinder along slit
Connect；
The built-in square magnet block of described object stage, into a single integrated structure with Magnet fixed bin, the table top outermost of object stage has an eaves.
Fixing device for vena caudalis injection of mouse the most according to claim 1, it is characterised in that described ring segment central authorities have
Hole.
Fixing device for vena caudalis injection of mouse the most according to claim 2, it is characterised in that described ring segment medium pore
Area be described annular iron plate 1/8-1/4.
Fixing device for vena caudalis injection of mouse the most according to claim 1, it is characterised in that described nut is band wing knot
Structure.
Fixing device for vena caudalis injection of mouse the most according to claim 1, it is characterised in that described cylinder door passes through left side
Fold and be connected with fixing cylinder, realize closing structure by hook and hook ring with fixing cylinder.
Fixing device for vena caudalis injection of mouse the most according to claim 5, it is characterised in that described hook is fixed on institute
Stating on the right side of cylinder door, described hook ring is fixed on the right side of fixing cylinder.
Fixing device for vena caudalis injection of mouse the most according to claim 1, it is characterised in that described holder and described
Object stage material is rustless steel.
Fixing device for vena caudalis injection of mouse the most according to claim 1, it is characterised in that described Magnet fixed bin with
The contact surface grained matte of absorbent bodies.
Fixing device for vena caudalis injection of mouse the most according to claim 1, it is characterised in that described object stage is described
The right side of holder, coordinates holder to use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510290587.9A CN104840268B (en) | 2015-06-01 | 2015-06-01 | Fixing device for vena caudalis injection of mouse and using method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510290587.9A CN104840268B (en) | 2015-06-01 | 2015-06-01 | Fixing device for vena caudalis injection of mouse and using method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104840268A CN104840268A (en) | 2015-08-19 |
| CN104840268B true CN104840268B (en) | 2016-11-16 |
Family
ID=53840533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510290587.9A Active CN104840268B (en) | 2015-06-01 | 2015-06-01 | Fixing device for vena caudalis injection of mouse and using method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN104840268B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106175974B (en) * | 2016-08-16 | 2017-10-13 | 卢丽花 | A kind of small white mouse vein intelligent injection device |
| CN106264772B (en) * | 2016-08-16 | 2017-09-22 | 程翌 | A kind of simple experiment on mice servicing unit |
| CN106264775B (en) * | 2016-08-16 | 2018-06-08 | 程翌 | A kind of operating method of simple experiment on mice auxiliary device |
| CN107411842A (en) * | 2017-09-22 | 2017-12-01 | 无锡市第五人民医院 | A kind of efficiently mouse tail vein injection device |
| CN108186154A (en) * | 2017-12-20 | 2018-06-22 | 中国科学院深圳先进技术研究院 | Inject auxiliary fixing device |
| CN108888382A (en) * | 2018-05-22 | 2018-11-27 | 上海市同济医院 | A kind of blood sampling of mouse tail vein and injection folder |
| CN109481078A (en) * | 2019-01-16 | 2019-03-19 | 沈阳建筑大学 | A kind of adjustable mouse tail vein injection fixator |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201171728Y (en) * | 2008-03-11 | 2008-12-31 | 上海睿智化学研究有限公司 | Mouse holder |
| CN201840546U (en) * | 2010-11-09 | 2011-05-25 | 高雄医学大学 | Experimental animal fixation device |
| CN201906030U (en) * | 2010-11-19 | 2011-07-27 | 高雄医学大学 | Experimental animal settling device |
| CN102451046A (en) * | 2010-10-25 | 2012-05-16 | 陈浩杰 | Fixing device for vena caudalis injection of mouse |
| CN104013477A (en) * | 2014-06-25 | 2014-09-03 | 李晓峰 | Experimental visual rat tail vein fixator |
| CN204274707U (en) * | 2014-11-28 | 2015-04-22 | 苏州大学 | Mouse tail vein injection fixture |
| CN204274715U (en) * | 2014-11-28 | 2015-04-22 | 苏州大学 | Experimental mouse tail vein injection heating-fixing apparatus |
| CN204766028U (en) * | 2015-06-01 | 2015-11-18 | 周平 | Mouse tail intravenous route fixing device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5670146B2 (en) * | 2010-10-15 | 2015-02-18 | 株式会社日立メディコ | Animal fixing device for diagnostic apparatus and operation support system using the same |
-
2015
- 2015-06-01 CN CN201510290587.9A patent/CN104840268B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201171728Y (en) * | 2008-03-11 | 2008-12-31 | 上海睿智化学研究有限公司 | Mouse holder |
| CN102451046A (en) * | 2010-10-25 | 2012-05-16 | 陈浩杰 | Fixing device for vena caudalis injection of mouse |
| CN201840546U (en) * | 2010-11-09 | 2011-05-25 | 高雄医学大学 | Experimental animal fixation device |
| CN201906030U (en) * | 2010-11-19 | 2011-07-27 | 高雄医学大学 | Experimental animal settling device |
| CN104013477A (en) * | 2014-06-25 | 2014-09-03 | 李晓峰 | Experimental visual rat tail vein fixator |
| CN204274707U (en) * | 2014-11-28 | 2015-04-22 | 苏州大学 | Mouse tail vein injection fixture |
| CN204274715U (en) * | 2014-11-28 | 2015-04-22 | 苏州大学 | Experimental mouse tail vein injection heating-fixing apparatus |
| CN204766028U (en) * | 2015-06-01 | 2015-11-18 | 周平 | Mouse tail intravenous route fixing device |
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| Publication number | Publication date |
|---|---|
| CN104840268A (en) | 2015-08-19 |
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Effective date of registration: 20190109 Address after: 235000 Zhongbang Pioneer Park, Duji District, Huaibei City, Anhui Province Patentee after: Anhui stone Software Technology Co. Ltd. Address before: 300070 Basic Medical Research Center, Tianjin Medical University, 22 Meteorological Station Road, Heping District, Tianjin Patentee before: Zhou Ping |