CN104825144B - Portable noninvasive continuous blood pressure monitoring sensing device - Google Patents

Portable noninvasive continuous blood pressure monitoring sensing device Download PDF

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CN104825144B
CN104825144B CN201510231435.1A CN201510231435A CN104825144B CN 104825144 B CN104825144 B CN 104825144B CN 201510231435 A CN201510231435 A CN 201510231435A CN 104825144 B CN104825144 B CN 104825144B
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blood pressure
pressure
sensing device
wrist strap
bluetooth wireless
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CN104825144A (en
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陆琼
刘伟庭
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Nanjing Antehai Technology Co ltd
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Abstract

The invention discloses the portable noninvasive continuous blood pressure monitoring sensing device of one kind.Including blood pressure continuous measurement intelligence sensor, data acquisition and Bluetooth wireless transmission module, blood pressure continuous measurement intelligence sensor is arranged on wrist strap with data acquisition and Bluetooth wireless transmission module, data acquisition and Bluetooth wireless transmission module are fixed on one end of wrist strap, and the other end of wrist strap and one end buckle type of wrist strap are connected;Blood pressure continuous measurement intelligence sensor can free adjustment position on wrist strap.The present invention expands the measurement range of blood pressure monitoring device using topping up cavity volume, effectively enhances position fault-tolerance when blood pressure monitoring device is worn;Using flexible sensitization array and it is adjacent to pressure-sensing device collection and position and is adjacent to force information, the accuracy of blood pressure measurement can be greatly improved with reference to the amendment data of storage;Using fixed impressed pressure, cancel pressure regulation device, be possibly realized so as to allow Wrist belt-type real-time continuous blood pressure accurately to measure.

Description

Portable noninvasive continuous blood pressure monitoring sensing device
Technical field
The present invention relates to sensing device, more particularly, to the portable noninvasive continuous blood pressure monitoring sensing device of one kind.
Background technology
Modern High-Tech makes rapid progress, the high speed development of internet, and we have welcome the big number of healthy living, Medicare According to the epoch.Country is also proposed the propulsion plan of fitness-for-all medical treatment in good time, and the development of healthy old-age care is supported energetically.The whole people The development of medical treatment, will promote the high effective integration of medical resource, promote the change of medical model, reduce huge medical expense and bear Load.And in this main trend, due to the demand driving of medical big data, light mobile data terminal harvester(Than Such as Wearable basic physiological parameter real-time acquisition device)Research and development turn into focus.Relative to the maturation of network technology, it may be said that this Class physiological data terminal lacks, it has also become the severe bottleneck of big data medical treatment.Although the commercialization health of existing profile fashion Bracelet, can record the daily exercise situation of people, and the indirect sleep quality for inferring people of action monitoring for passing through hand.Also deposit In the medical Holter systems of the continuous ECG monitorings of specialty(Dynamic ecg monitoring system).It should say, so far, have no business Industry, wearing comfort is good, do not influence people's daily routines, suitable for the long-term continuous real-time physiological parameter monitoring of human body Mobile data terminal.
With the high speed development of society, the dietary structure of people also quietly changes, " three high " phenomenon in modern society Protrude very much, had a strong impact on daily life and physical and mental health.The development of society, life and work tempo increase is also given The pressure that large quantities of working clans bring also is increased rapidly, and many people are in sub-health state.Meanwhile, China quickly steps into aging society Meeting, the aftereffect of family planning policy result in more and more " empty nest " family and be formed.In view of above trend, research and development are suitable to wear The mobile data terminal for the basic physiological parameter current events monitoring worn, is modern technologies and the demand of social development, and is developed properly Intelligent sensing device is that it is crucial.
Blood pressure can reflect the function status of human heart and blood vessel as one of human body basic physiology parameter, be to face The important evidence diagnosed the illness on bed, observe therapeutic effect, carried out Index for diagnosis.Human blood-pressure is with physiological period, individual human feelings Thread, the external world and inherence various stimulations and produce change, with obvious fluctuation.
Because blood pressure parameter is influenceed by factors such as health, environmental condition and the physiology rhythms, single measurement or There is bigger difference in the result discontinuously measured, and method for continuous measuring can measure blood pressure in each cardiac cycle, in clinical and doctor Learning has prior meaning in research.The change for changing the sympathetic nerve activity parallel with normally sleeping-waking up the cycle of blood pressure It is relevant.For sudden cardiovascular and cerebrovascular disease, Morning Blood Pressure has very important significance.Pathologic, physiologic and epidemiology Research shows the occurrence probability increase in the morning of SCD, acute myocardial infarction AMI, cerebrovascular disease and cerebral apoplexy.Pass through continuous blood Pressure monitoring, this symptom can be found in time, be patient and doctor predicts the development of the state of an illness and wins the quality time.Continuous blood pressure is surveyed Amount can provide corresponding blood pressure transition information, so that deduction and sleep quality for sleep info, by stages and sleep-disorder Diagnosis provide foundation.
Stethoscopy:Stethoscopy (Auscultatory Method), also known as Korotkoff's Sound method (Korotkoff-Sound Method), it is one of most non-invasive detection method of clinical practice, its principle is to utilize to inflate cuff compressing arteries, With the decline of cuff pressure, arteries in complete blocking-gradually open-standard-sized sheet change procedure, by distinguish artery blood flow by Cross streaming voice and corresponding pressure spot to determine systolic pressure and diastolic pressure during resistance.There is inflation-deflation course, so not Human body artery blood pressure can continuously be measured.
Oscillographic method:Oscillographic method (Oscillometric method), also referred to as vibration measuring method or vibratory drilling method, are clinically each The widely used blood pressure measurement technology of class patient monitor, electronic sphygmomanometer.Blood pressure cuff is entangled on patient's arm, what cuff was picked out Rubber tube is connected on the air pump of non-invasive blood pressure (NIBP) circuit board.Air pump to cuff inflation, make arm arteries close this When be blocked because of blood flow, the pressure sensor on NIBP plates is only capable of detecting the cuff pressure of static state, and does not detect artery blood flow Pulse (beating), at this moment inflation stops, vent valve starts progressively to deflate under control circuit function, and cuff pressure is gradually reduced, The arteries of closure gradually opens, and begins with blood flow and flows through.Then pressure sensor, which is able to detect that, is superimposed upon in cuff pressure Pulsatile arterial blood pressure.
Angiosthenia method(Arterial Tonometry):It is to be applied by being pointed to the body surface artery part near bone External pressure, it is in flat form to make it.Now artery acts on the power on the surface approximate with the pressure in artery into rigid surface state It is proportional.Therefore can be by measuring the pressure transducer for being placed in radial artery position the pressure on the surface, thus obtain To the arterial pressure waveform often clapped, and detect the maximum and minimum signal of arteriopalmus to obtain pressure value.Angiosthenia method can Continuously to measure arterial pressure, but this method is high to sensor positioning requirements, must be long by angiosthenia on bone during installation During time measurement, keep sensor measurement position more difficult.Meanwhile, the need for the application of external pressure and adjusting apparatus, general In the case of the method be also difficult to turn into Worn type equipment.The difficult problem of positioning, also limit its application.
Volume-compensation method:Also known as vascular unloading technique, is in artery by preset reference pressure value and goes load condition, Changed simultaneously using servo-drive system compensation arterial volume caused by the change of artery internal pressure, make arterial volume maintain to go load to move Arteries and veins volume, now oversleeve internal pressure is equal to artery internal pressure, therefore can measure arterial pressure indirectly by measuring oversleeve internal pressure.This method Implementation process need a pressure servomechanism, can adjust impressed pressure in real time according to fluctuation of blood pressure is in vascular wall Constant volume state.Volume-compensation method is continuous BP measurement method more ripe at present.Measurement apparatus is complicated, to quilt when using Examination person makes troubles, and is also not suitable for using in the observation of long-time continuous blood pressure.
Plethysmography:In heart beat cycles, flowed through in the arteriole, capillary and venule in peripheral vascular Blood accordingly in pulsating nature change.Volumetric blood is maximum when the heart contracts, and volume is minimum in diastole.Blood This pulsating nature change of volume, can typically be obtained by photoelectricity volume sensor, contain volume pulse blood in the waveform of gained Information.Therefore diastolic pressure and systolic pressure, this method can be obtained by volume pulse blood information and the relation of blood pressure signal It is referred to as photoplethysmography.Generally measured in finger tip, because finger tip blood flow experiences area greatly, to test position requirement It is less strict;The adaptability of signal, stability and repeatability are superior.But the mechanism for volume pulse blood signal is special with information Relation does not have abundant announcement between levying, and precision is difficult to ensure that.
Pulse velocity of wave determination method:According to pulse wave along between artery propagation rate and arterial pressure have positively related feature Propose, arterial pressure value is extrapolated indirectly by measuring pulse velocity of wave.
In summary, stethoscopy, oscillographic method and volume-compensation method are only suitable for batch (-type) measurement;Plethysmography, pulse wave Fast determination method can be used for continuous BP measurement, and the former precision is difficult to ensure that, the latter needs multimetering, is unfavorable for wrist blood pressure Portable, the design for aesthetic of meter.
The content of the invention
It is an object of the invention to provide the portable noninvasive continuous blood pressure monitoring sensing device of one kind, using angiosthenia method With direct measurement absolute blood pressure, blood pressure measuring device has been innovated, sensing station fault freedom is improved, blood vessel positioning hardly possible is solved Problem;The flexible sensitization array of increase assigns sensing device vessel position and determines ability, develops blood pressure correction algorithm;In measurement, adopt With fixed impressed pressure, cancel pressure regulation device, ensure the accuracy of sensing device blood pressure output with secondary correction algorithm, So as to allow Wrist belt-type real-time continuous blood pressure measurement to be possibly realized.
The technical solution adopted by the present invention is:
The present invention includes blood pressure continuous measurement intelligence sensor, data acquisition and Bluetooth wireless transmission module, and blood pressure is continuous Measure intelligence sensor to be arranged on wrist strap with data acquisition and Bluetooth wireless transmission module, data acquisition and Bluetooth wireless transmission Module is fixed on one end of wrist strap, and the other end of wrist strap and one end buckle type of wrist strap are connected;Blood pressure continuous measurement intelligent sensing Device can free adjustment position on wrist strap;Blood pressure continuous measurement intelligence sensor is integrated with flexible sensitization array, is adjacent to pressure quick Sensing unit and monitoring of blood pressure pressure-sensing device, three parameters of blood pressure are calculated to obtain:I.e. arteries position, is adjacent to Pressure size and arteries pressure;Two kinds of sensor signals processing electricity in data acquisition and Bluetooth wireless transmission module Road:That is piezoelectric signal process circuit, pressure drag signal processing circuit, piezoelectric signal, pressure drag signal are through two kinds of sensor signals After process circuit conditioning, after being converted by A/D in input microprocessor unit;Microprocessor unit is by reading information-storing device The correction model of middle preservation, real-time blood pressure is calculated using three parameters;Microprocessor unit passes through Bluetooth wireless transmission Unit is contacted with mobile terminal, and real-time blood pressure information is transferred into mobile terminal preserves and be uploaded to medical institutions;Microprocessor Unit controls minicell to be system power supply by voltage modulate circuit.
The structure of the blood pressure continuous measurement intelligence sensor, including flexible sensitization array, topping up cavity volume, monitoring of blood pressure pressure Force sensitive element, outer rigid housing is adjacent to pressure-sensing device, rigid support;
In outer rigid housing, the flexible sensitization array of piezoelectric membrane and strip shaped electric poles composition is wired to piezoelectricity Signal processing circuit, the strip shaped electric poles of flexible sensitization array are attached to skin layer, and the piezoelectric membrane of flexible sensitization array, which is attached to, to be full of It is rigid support around the top of the topping up cavity volume of silicone oil, topping up cavity volume, the bottom of topping up cavity volume is posted to be made up of ultra thin silicon wafers Monitoring of blood pressure pressure-sensing device, ultra thin silicon wafers are wired to pressure drag signal processing circuit, in outer rigid housing bottom Equipped with pressure-sensing device is adjacent between wrist strap, it is adjacent to pressure-sensing device and is wired to pressure drag signal transacting electricity Road.
The flexible sensitization array is close to the upper uniform arrangement in skin layer side, and its surface electrode is in strip and size keeps one Cause, strip length direction is consistent with arteries direction.
The microprocessor unit uses the S3C2410 embedded microprocessors of the ARM frameworks of Samsung;Two kinds of sensings Piezoelectric signal process circuit, pressure drag signal processing circuit is respectively adopted in device signal processing circuit;Information-storing device is configured with power down The FLASH of the defencive function and RAM without power-down protection;Minicell uses button-shaped chargeable lithium cell;Bluetooth is wireless Transport module uses the T2541 microminiature bluetooth modules of TDK companies.
The invention has the advantages that:
The present invention expands the measurement range of blood pressure monitoring device using topping up cavity volume, effectively enhances blood pressure monitoring device Position fault-tolerance when wearing;Using flexible sensitization array and it is adjacent to pressure-sensing device collection and position and is adjacent to force information, ties The accuracy of blood pressure measurement can be greatly improved by closing the amendment data of storage;Using fixed impressed pressure, cancel pressure adjustment Device, is possibly realized so as to allow Wrist belt-type real-time continuous blood pressure accurately to measure.
Brief description of the drawings
Fig. 1 is the application method schematic diagram of the present invention.
Fig. 2 is the structural representation of the present invention.
Fig. 3 is the theory structure block diagram of the present invention.
Fig. 4 is the structural representation of blood pressure continuous measurement intelligence sensor.
Fig. 5 is the method for work schematic diagram of flexible sensitization array.
Fig. 6 is piezoelectric membrane output signal diagram of the flexible sensitization arrays of Fig. 5 in diverse location.
Fig. 7 is monitoring of blood pressure pressure-sensing device method of work schematic diagram.
In figure:1st, medical institutions, 2, mobile terminal, 3, user, 4, sensing device, 5, blood pressure continuous measurement intelligent sensing Device, 6, wrist strap, 7, data acquisition and Bluetooth wireless transmission module, 8, skin layer, 9, flexible sensitization array, 10, topping up cavity volume, 11st, monitoring of blood pressure pressure-sensing device, 12, outer rigid housing, 13, be adjacent to pressure-sensing device, 14, arteries, 15, strip electricity Pole, 16, piezoelectric membrane, 17, rigid support, 18, ultra thin silicon wafers.
Embodiment
The invention will be further described with reference to the accompanying drawings and examples.
As shown in Figure 1 and Figure 2, user 3 includes sensing device 4 and mobile terminal 2, and sensing device 4 is worn on watch profile The wrist portion of user 3, ensures that blood pressure continuous measurement intelligence sensor 5 is directly steadily contacted with pulse location, by real-time blood with wrist strap 6 Pressure information transfer preserves to mobile terminal 2 and is uploaded to medical institutions 1.
As shown in Figure 1, Figure 2, Figure 3 shows, the present invention includes blood pressure continuous measurement intelligence sensor 5, data acquisition and bluetooth without Line transport module 7, blood pressure continuous measurement intelligence sensor 5 is arranged on wrist strap 6 with data acquisition and Bluetooth wireless transmission module 7 On, data acquisition and Bluetooth wireless transmission module 7 are fixed on one end of wrist strap 6, and one end of the other end and wrist strap 6 of wrist strap 6 is taken Button is connected;Blood pressure continuous measurement intelligence sensor 5 can free adjustment position on wrist strap 6.
Blood pressure continuous measurement intelligence sensor 5 is integrated with flexible sensitization array 9, is adjacent to pressure-sensing device 13 and blood pressure Pressure-sensing device 11 is monitored, three parameters of blood pressure are calculated to obtain:That is the position of arteries 14, be adjacent to pressure size with And the pressure of arteries 14;Two kinds of sensor signal processing circuits in data acquisition and Bluetooth wireless transmission module 7:That is piezoelectricity Signal processing circuit, pressure drag signal processing circuit, piezoelectric signal, pressure drag signal are adjusted through two kinds of sensor signal processing circuits After reason, after being converted by A/D in input microprocessor unit;What microprocessor unit was preserved by reading in information-storing device repaiies Positive model, real-time blood pressure is calculated using three parameters;Microprocessor unit passes through Bluetooth wireless transmission unit and movement Terminal contact, is transferred to mobile terminal 2 by real-time blood pressure information and preserves and be uploaded to medical institutions 1;Microprocessor unit passes through Voltage modulate circuit controls minicell to be system power supply.
Flexible sensitization array 9 is distributed and its corresponding arteries location determining method.The flexible sensitization array 9 is leaned on Nearly skin layer 8 upper uniform arrangement sideways, its surface electrode is consistent in strip and size, strip length direction and arteries Direction is consistent.The pressure positive correlation that the output charge size of each strip piezoelectric membrane is subject to it, when whole medial surface is adjacent to During vascular site, it can be sentenced by comparing the electric charge size gradient relation collected from each electrode in flexible sensitization array 9 Position of the disconnected blood vessel with respect to monitoring device.
The primary calibration method that vessel position parameter is exported for monitoring of blood pressure sensing element.Supervised because arteries is relative The difference of setting position is surveyed, the pressure output that monitoring of blood pressure pressure-sensing device is collected by topping up cavity volume can produce deviation. With reference to the position deviation amendment data being pre-stored in information-storing device, monitoring device monitoring of blood pressure sensing element can be exported into Row calibration.
Described is adjacent to the method that pressure sensitive cells determine to be adjacent to pressure.When monitoring device by wrist strap is fixed on human hand During wrist, it is adjacent to pressure-sensing device and is located between outer rigid housing and wrist strap, when tightening up wrist strap with stationary monitoring device, be adjacent to Pressure-sensing device can obtain thrust size of the wrist strap to outer rigid housing, that is to say monitoring device to skin to be adjacent to power big It is small.
It is adjacent to the secondary calibration method that pressure is exported for monitoring of blood pressure sensing element.It can influence to move due to being adjacent to power size Arteries and veins blood pressure, with reference to the arterial pressure amendment data on being adjacent to power being pre-stored in information-storing device, monitoring device can be to blood Pressure monitoring sensing element output is calibrated again.
As shown in figure 4, the structure of the blood pressure continuous measurement intelligence sensor 5, including flexible sensitization array 9, topping up appearance Chamber 10, monitoring of blood pressure pressure-sensing device 11, outer rigid housing 12 is adjacent to pressure-sensing device 13, rigid support 17;It is outer in rigidity In shell 12, the flexible sensitization array 9 that piezoelectric membrane 16 and strip shaped electric poles 15 are constituted is wired to piezoelectric signal processing electricity Road (using the capacitive feedback circuit of high input impedance), the strip shaped electric poles 15 of flexible sensitization array 9 are attached to skin layer 8, flexible quick It is rigid support 17 that the piezoelectric membrane 16 of sense array 9, which is attached to around the top of the topping up cavity volume 10 full of silicone oil, topping up cavity volume 10, Post the monitoring of blood pressure pressure-sensing device 11 being made up of the ultra thin silicon wafers 18, (thickness of ultra thin silicon wafers 18 in the bottom of topping up cavity volume 10 20 microns to 50 microns) it is wired to pressure drag signal processing circuit(Using four-terminal measurement circuit), in outer rigid housing 12 Equipped with pressure-sensing device 13 is adjacent between bottom and wrist strap 6, using silicon substrate sensing element, it is adjacent to pressure-sensing device 13 and passes through Wire is connected to pressure drag signal processing circuit.
As shown in figure 5, judging the schematic diagram of the location method of arteries 14 for flexible sensitization array 9.Flexible sensitization array 9 Upper piezoelectric membrane 16 ensures that the length direction of its strip shaped electric poles 15 is consistent with the direction of arteries 14 at pulse when mounted.When When flexible sensitization array 9 is adjacent to pulse location, piezoelectric membrane 16 suffers oppression generation electric charge, electric charge size and stress rate of change positive Close;When arteries 14 is pulsed, the stress rate of change of piezoelectric membrane 16 closer to vessel position is bigger, takes this as a foundation, micro- Processor unit by compare be in discrete location strip shaped electric poles 15 instantaneous output signal, the surface of skin layer 8 can be obtained Coordinate where the full curve of pressure change rate, curve peak is the relative position of arteries 14, as shown in Figure 6.
As shown in fig. 7, measuring the schematic diagram of pulse vascular pressure method for monitoring of blood pressure pressure-sensing device 11.Topping up holds The surrounding of chamber 10 is rigid support 17, and the front end close to skin is sealed by piezoelectric membrane 16, and monitoring of blood pressure pressure-sensing device 11 is pacified Silicone oil is full of in the other end, cavity volume.When arteries 14 is beaten, skin layer 8 is outwardly against passing through flexible sensitization array 9 are transferred the pressure on piezoelectric membrane 16, and film deforms, and intracavity liquid is held in extruding, and liquid pressure is improved, finally led therewith The ultra thin silicon wafers 18 in monitoring of blood pressure pressure-sensing device 11 are caused to deform upon, therefore, pressure drag material resistance variations are with moving thereon The pressure change that the pulsation of arteries and veins blood vessel 14 is produced has uniformity.The uncertain vascular pressure in position is changed into liquid by topping up cavity volume 10 Pressure, improves the measurement range of monitoring of blood pressure pressure-sensing device 11.

Claims (3)

1. a kind of portable noninvasive continuous blood pressure monitoring sensing device, it is characterised in that:Including blood pressure continuous measurement intelligent sensing Device(5), data acquisition and Bluetooth wireless transmission module(7), blood pressure continuous measurement intelligence sensor(5)With data acquisition and bluetooth Wireless transport module(7)Installed in wrist strap(6)On, data acquisition and Bluetooth wireless transmission module(7)It is fixed on wrist strap(6)One End, wrist strap(6)The other end and wrist strap(6)The connection of one end buckle type;Blood pressure continuous measurement intelligence sensor(5)In wrist strap (6)The upper free adjustment position of energy;Blood pressure continuous measurement intelligence sensor(5)It is integrated with flexible sensitization array(9), it is adjacent to pressure quick Sensing unit(13)And monitoring of blood pressure pressure-sensing device(11), three parameters of blood pressure are calculated to obtain:That is arteries (14)Position, is adjacent to pressure size and arteries(14)Pressure;Data acquisition and Bluetooth wireless transmission module(7)In two Plant sensor signal processing circuit:That is piezoelectric signal process circuit, pressure drag signal processing circuit, piezoelectric signal, pressure drag signal warp After two kinds of sensor signal processing circuits conditioning, after being converted by A/D in input microprocessor unit;Microprocessor unit The correction model preserved by reading in information-storing device, real-time blood pressure is calculated using three parameters;Microprocessor list Member is contacted by Bluetooth wireless transmission unit and mobile terminal, and real-time blood pressure information is transferred into mobile terminal(2)Preserve and on It is transmitted to medical institutions(1);Microprocessor unit controls minicell to be system power supply by voltage modulate circuit;
The blood pressure continuous measurement intelligence sensor(5)Structure, including flexible sensitization array(9), topping up cavity volume(10), blood pressure Monitor pressure-sensing device(11), outer rigid housing(12), it is adjacent to pressure-sensing device(13), rigid support(17);It is outer in rigidity Shell(12)It is interior, piezoelectric membrane(16)And strip shaped electric poles(15)The flexible sensitization array of composition(9), it is wired to piezoelectricity letter Number process circuit, flexible sensitization array(9)Strip shaped electric poles(15)It is attached to skin layer(8), flexible sensitization array(9)Piezoelectricity it is thin Film(16)It is attached to the topping up cavity volume full of silicone oil(10)Top, topping up cavity volume(10)Surrounding is rigid support(17), topping up appearance Chamber(10)Bottom post by ultra thin silicon wafers(18)The monitoring of blood pressure pressure-sensing device of composition(11), ultra thin silicon wafers(18)Pass through Wire is connected to pressure drag signal processing circuit, in outer rigid housing(12)Bottom and wrist strap(6)Between equipped be adjacent to presser sensor member Part(13), it is adjacent to pressure-sensing device(13)It is wired to pressure drag signal processing circuit.
2. the portable noninvasive continuous blood pressure monitoring sensing device of one kind according to claim 1, it is characterised in that:It is described soft Property sensitization array(9)Close to skin layer(8)Uniform arrangement on side, its surface electrode is consistent in strip and size, strip Length direction is consistent with arteries direction.
3. the portable noninvasive continuous blood pressure monitoring sensing device of one kind according to claim 1, it is characterised in that:It is described micro- Processor unit uses the S3C2410 embedded microprocessors of the ARM frameworks of Samsung;Two kinds of sensor signal processing circuits Piezoelectric signal process circuit, pressure drag signal processing circuit is respectively adopted;Information-storing device is configured with the FLASH of power-down protection With the RAM without power-down protection;Minicell uses button-shaped chargeable lithium cell;Bluetooth wireless transmission module uses TDK The T2541 microminiature bluetooth modules of company.
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